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Conserved domains on  [gi|568983180|ref|XP_006517230|]
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BRCA1-A complex subunit RAP80 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RAP80_UIM super family cl39632
RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 ...
 72-128 3.13e-21

RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 protein present in Homo sapiens. RAP80 is fundamental for protein recruitment in the DNA damage response. The N-terminal domain is a ubiquitin-interacting motif (UIM). RAP80 is involved in multivalent recognition of polyUb chains through N-terminal domain.


The actual alignment was detected with superfamily member pfam18282:

Pssm-ID: 436382 [Multi-domain]  Cd Length: 57  Bit Score: 87.18  E-value: 3.13e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568983180   72 AKRKVAHMSEEEQFALALKMSEQEAREVNNQEEKEEELLRKAIAESLNSCWSSAASA 128
Cdd:pfam18282   1 AKRKIAHMSEDEQFALALKMSEQEAMELNNQEEEEEELLRKAIAESLNSCQLPAASA 57
 
Name Accession Description Interval E-value
RAP80_UIM pfam18282
RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 ...
 72-128 3.13e-21

RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 protein present in Homo sapiens. RAP80 is fundamental for protein recruitment in the DNA damage response. The N-terminal domain is a ubiquitin-interacting motif (UIM). RAP80 is involved in multivalent recognition of polyUb chains through N-terminal domain.


Pssm-ID: 436382 [Multi-domain]  Cd Length: 57  Bit Score: 87.18  E-value: 3.13e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568983180   72 AKRKVAHMSEEEQFALALKMSEQEAREVNNQEEKEEELLRKAIAESLNSCWSSAASA 128
Cdd:pfam18282   1 AKRKIAHMSEDEQFALALKMSEQEAMELNNQEEEEEELLRKAIAESLNSCQLPAASA 57
 
Name Accession Description Interval E-value
RAP80_UIM pfam18282
RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 ...
 72-128 3.13e-21

RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 protein present in Homo sapiens. RAP80 is fundamental for protein recruitment in the DNA damage response. The N-terminal domain is a ubiquitin-interacting motif (UIM). RAP80 is involved in multivalent recognition of polyUb chains through N-terminal domain.


Pssm-ID: 436382 [Multi-domain]  Cd Length: 57  Bit Score: 87.18  E-value: 3.13e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568983180   72 AKRKVAHMSEEEQFALALKMSEQEAREVNNQEEKEEELLRKAIAESLNSCWSSAASA 128
Cdd:pfam18282   1 AKRKIAHMSEDEQFALALKMSEQEAMELNNQEEEEEELLRKAIAESLNSCQLPAASA 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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