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Conserved domains on  [gi|568984193|ref|XP_006517580|]
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A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 229-339 4.17e-38

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 136.55  E-value: 4.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984193  229 IEGFFNDSlPRGGYMEVVQIPRGSVHIEVREVSMSKNYIALKSEGDDYYINGAWTID-WPRKFDVSGTAFHYKRPTDEPE 307
Cdd:pfam05986   2 VSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPALE 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568984193  308 SLEALGPTSENLIVMVLLQ---EQNLGIRYKFNVP 339
Cdd:pfam05986  81 ELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 354-409 1.47e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.25  E-value: 1.47e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568984193  354 WTYQPWAECSATCAGGVQRQEVVCKRLDDNSIVQNNFCDPDSKPPEnQRACNTEPC 409
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 71-123 3.35e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.15  E-value: 3.35e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568984193    71 WGSWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCP 123
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 413-469 8.53e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 8.53e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568984193  413 WFIGDWLECSKTCDGGMRTRAVLCIRKVGPSEEEtlDYGDCLTHRPVEKESCNNQSC 469
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVP--DSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 128-226 2.64e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 63.96  E-value: 2.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984193  128 DFREKQCADFDSMPFRGKHYNWKPYTGGGVKP-------CALNCLAEGYNFYTERAPAVIDGTQCNAD------SLDICI 194
Cdd:pfam19236   4 EFMSQQCARTDGQPLRSSPGGASFYHWGAAVPhsqgdalCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLCV 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568984193  195 NGECKHVGCDNILGSDAREDRCRVCGGDGSTC 226
Cdd:pfam19236  84 LGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 473-527 1.31e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 1.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568984193  473 WVALDWSECTPKCGSGFKHRIVLCKSSDLSKTFPAAQCPEESKPPARIRCSLGRC 527
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 532-581 1.32e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 1.32e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568984193  532 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASV---DCPETVRPPSMQQCDSK 581
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpdsECSAQKKPPETQSCNLK 53
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 593-625 7.58e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 45.60  E-value: 7.58e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568984193  593 CKDvnKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 625
Cdd:pfam08686   1 CKD--KFANCSLVVQARLCSHKYYRQFCCRSCS 31
ADAMTS_CR_2 super family cl39281
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 10-58 2.24e-06

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


The actual alignment was detected with superfamily member pfam17771:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 45.41  E-value: 2.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568984193   10 PPMQIWVCRELWC-LSKSNRCVTNSIPAAEGTLCqtgnIEKGWCYQGDCV 58
Cdd:pfam17771  23 PNGDEDVCSKLWCsNPGGSTCTTKNLPAADGTPC----GNKKWCLNGKCV 68
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 229-339 4.17e-38

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 136.55  E-value: 4.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984193  229 IEGFFNDSlPRGGYMEVVQIPRGSVHIEVREVSMSKNYIALKSEGDDYYINGAWTID-WPRKFDVSGTAFHYKRPTDEPE 307
Cdd:pfam05986   2 VSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPALE 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568984193  308 SLEALGPTSENLIVMVLLQ---EQNLGIRYKFNVP 339
Cdd:pfam05986  81 ELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 354-409 1.47e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.25  E-value: 1.47e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568984193  354 WTYQPWAECSATCAGGVQRQEVVCKRLDDNSIVQNNFCDPDSKPPEnQRACNTEPC 409
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 71-123 3.35e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.15  E-value: 3.35e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568984193    71 WGSWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCP 123
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 413-469 8.53e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 8.53e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568984193  413 WFIGDWLECSKTCDGGMRTRAVLCIRKVGPSEEEtlDYGDCLTHRPVEKESCNNQSC 469
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVP--DSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 128-226 2.64e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 63.96  E-value: 2.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984193  128 DFREKQCADFDSMPFRGKHYNWKPYTGGGVKP-------CALNCLAEGYNFYTERAPAVIDGTQCNAD------SLDICI 194
Cdd:pfam19236   4 EFMSQQCARTDGQPLRSSPGGASFYHWGAAVPhsqgdalCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLCV 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568984193  195 NGECKHVGCDNILGSDAREDRCRVCGGDGSTC 226
Cdd:pfam19236  84 LGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 473-527 1.31e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 1.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568984193  473 WVALDWSECTPKCGSGFKHRIVLCKSSDLSKTFPAAQCPEESKPPARIRCSLGRC 527
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 532-581 1.32e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 1.32e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568984193  532 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASV---DCPETVRPPSMQQCDSK 581
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpdsECSAQKKPPETQSCNLK 53
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 593-625 7.58e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 45.60  E-value: 7.58e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568984193  593 CKDvnKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 625
Cdd:pfam08686   1 CKD--KFANCSLVVQARLCSHKYYRQFCCRSCS 31
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 10-58 2.24e-06

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 45.41  E-value: 2.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568984193   10 PPMQIWVCRELWC-LSKSNRCVTNSIPAAEGTLCqtgnIEKGWCYQGDCV 58
Cdd:pfam17771  23 PNGDEDVCSKLWCsNPGGSTCTTKNLPAADGTPC----GNKKWCLNGKCV 68
TSP_1 pfam00090
Thrombospondin type 1 domain;
74-122 1.95e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 42.02  E-value: 1.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 568984193   74 WSLWGECSRTCGGGVSSSLRHCDSPAPsgGGKYCLGERKRYRSCNTDPC 122
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 416-470 2.54e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 2.54e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568984193   416 GDWLECSKTCDGGMRTRAVLCIRKVGPSEEETldygdcLTHRPVEKESCNNQSCP 470
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGP------CTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 353-410 5.77e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.26  E-value: 5.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568984193   353 MWTYQPWAECSATCAGGVQRQEVVCkrLDDNSIVQNNFCDPDSKppeNQRACNTEPCP 410
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSC--CSPPPQNGGGPCTGEDV---ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 532-579 5.77e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.26  E-value: 5.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568984193   532 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASV-DCPET---VRPPSMQQCD 579
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGgPCTGEdveTRACNEQPCP 53
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 229-339 4.17e-38

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 136.55  E-value: 4.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984193  229 IEGFFNDSlPRGGYMEVVQIPRGSVHIEVREVSMSKNYIALKSEGDDYYINGAWTID-WPRKFDVSGTAFHYKRPTDEPE 307
Cdd:pfam05986   2 VSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPALE 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568984193  308 SLEALGPTSENLIVMVLLQ---EQNLGIRYKFNVP 339
Cdd:pfam05986  81 ELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 354-409 1.47e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.25  E-value: 1.47e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568984193  354 WTYQPWAECSATCAGGVQRQEVVCKRLDDNSIVQNNFCDPDSKPPEnQRACNTEPC 409
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 71-123 3.35e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.15  E-value: 3.35e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568984193    71 WGSWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCP 123
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 413-469 8.53e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 8.53e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568984193  413 WFIGDWLECSKTCDGGMRTRAVLCIRKVGPSEEEtlDYGDCLTHRPVEKESCNNQSC 469
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVP--DSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 128-226 2.64e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 63.96  E-value: 2.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984193  128 DFREKQCADFDSMPFRGKHYNWKPYTGGGVKP-------CALNCLAEGYNFYTERAPAVIDGTQCNAD------SLDICI 194
Cdd:pfam19236   4 EFMSQQCARTDGQPLRSSPGGASFYHWGAAVPhsqgdalCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLCV 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568984193  195 NGECKHVGCDNILGSDAREDRCRVCGGDGSTC 226
Cdd:pfam19236  84 LGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 473-527 1.31e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 1.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568984193  473 WVALDWSECTPKCGSGFKHRIVLCKSSDLSKTFPAAQCPEESKPPARIRCSLGRC 527
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 532-581 1.32e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 1.32e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568984193  532 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASV---DCPETVRPPSMQQCDSK 581
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpdsECSAQKKPPETQSCNLK 53
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 593-625 7.58e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 45.60  E-value: 7.58e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568984193  593 CKDvnKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 625
Cdd:pfam08686   1 CKD--KFANCSLVVQARLCSHKYYRQFCCRSCS 31
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 10-58 2.24e-06

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 45.41  E-value: 2.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568984193   10 PPMQIWVCRELWC-LSKSNRCVTNSIPAAEGTLCqtgnIEKGWCYQGDCV 58
Cdd:pfam17771  23 PNGDEDVCSKLWCsNPGGSTCTTKNLPAADGTPC----GNKKWCLNGKCV 68
TSP_1 pfam00090
Thrombospondin type 1 domain;
74-122 1.95e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 42.02  E-value: 1.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 568984193   74 WSLWGECSRTCGGGVSSSLRHCDSPAPsgGGKYCLGERKRYRSCNTDPC 122
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 72-122 1.25e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.96  E-value: 1.25e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568984193   72 GSWSLWGECSRTCGGGVSSSLRHCDSPaPSGGGKYCLGERKRyRSCNTDPC 122
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPCPELLER-RPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 416-470 2.54e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 2.54e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568984193   416 GDWLECSKTCDGGMRTRAVLCIRKVGPSEEETldygdcLTHRPVEKESCNNQSCP 470
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGP------CTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 353-410 5.77e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.26  E-value: 5.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568984193   353 MWTYQPWAECSATCAGGVQRQEVVCkrLDDNSIVQNNFCDPDSKppeNQRACNTEPCP 410
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSC--CSPPPQNGGGPCTGEDV---ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 532-579 5.77e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.26  E-value: 5.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568984193   532 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASV-DCPET---VRPPSMQQCD 579
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGgPCTGEdveTRACNEQPCP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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