NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568987672|ref|XP_006519072|]
View 

SLIT and NTRK-like protein 6 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-196 5.02e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 5.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  45 HLSLLNNGLTMLHTnDFSGLTNALSIHLGFNNIADIeTGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 124
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987672 125 ITIIePSAFSKLNRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 196
Cdd:COG4886  217 LTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
365-493 2.91e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 365 LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLNKGmFLGLHSLEYLYLEYNAVKEIlPGTFNPMPKLKVLYLNN 444
Cdd:COG4886  115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568987672 445 NLLQVLPAHIFLGIPLTRVNLKTNQFTHLPVSniLDDLDFLIQIDLEDN 493
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
LRRCT smart00082
Leucine rich repeat C-terminal domain;
493-543 1.16e-05

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.19  E-value: 1.16e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568987672   493 NPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCP 543
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
195-245 1.18e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.41  E-value: 1.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568987672   195 NKWACNCELLQLKNWLEN--MPPQSiiGDVICYSPPPFKGSVLSRLKKESFCP 245
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-196 5.02e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 5.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  45 HLSLLNNGLTMLHTnDFSGLTNALSIHLGFNNIADIeTGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 124
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987672 125 ITIIePSAFSKLNRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 196
Cdd:COG4886  217 LTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
365-493 2.91e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 365 LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLNKGmFLGLHSLEYLYLEYNAVKEIlPGTFNPMPKLKVLYLNN 444
Cdd:COG4886  115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568987672 445 NLLQVLPAHIFLGIPLTRVNLKTNQFTHLPVSniLDDLDFLIQIDLEDN 493
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
364-421 4.16e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 4.16e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568987672  364 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYN 421
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 321-494 9.18e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 9.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 321 IHCQERNIESLSDLQPPPhNPRKLILAGNIIHTLmkSDLTDYFTLEMLHLGNNRIEVLEegSFMNLTRLQKLYLNGNHLT 400
Cdd:cd21340    7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 401 KLnKGmFLGLHSLEYLYLEYNAVKEILPGTFNPM------PKLKVLYL-NNNL-----LQVLPAhiflgipLTRVNLKTN 468
Cdd:cd21340   82 VV-EG-LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNIsGNNIdslepLAPLRN-------LEQLDASNN 152

                        170       180
                 ....*....|....*....|....*..
gi 568987672 469 QFTHL-PVSNILDDLDFLIQIDLEDNP 494
Cdd:cd21340  153 QISDLeELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
69-123 2.03e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.03e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568987672   69 SIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 123
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-176 1.49e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  45 HLSLLNNGLTMLhtNDFSGLTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLE-----ILKEDTFHGL-ENLEFL 118
Cdd:cd21340   50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVL 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987672 119 QADNNFITIIEPsaFSKLNRLKVLILNDNAIESLPpNIFRFVP----LTHLDLRGNQLQTLP 176
Cdd:cd21340  126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLE-ELLDLLSswpsLRELDLTGNPVCKKP 184
LRRCT smart00082
Leucine rich repeat C-terminal domain;
493-543 1.16e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.19  E-value: 1.16e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568987672   493 NPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCP 543
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT smart00082
Leucine rich repeat C-terminal domain;
195-245 1.18e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.41  E-value: 1.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568987672   195 NKWACNCELLQLKNWLEN--MPPQSiiGDVICYSPPPFKGSVLSRLKKESFCP 245
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 464-579 1.40e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.38  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672   464 NLKTNQFTHLPvSNILDDLDFLIQIDLEDNPWDCSCDLVGLQQWIHKLG-KGTMTDDILCTSPGHLDKKELkaLNSDLLC 542
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGvKVRQPEAALCAGPGALAGQPL--LGIPLLD 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 568987672   543 PGLVNNpsmptqttYVIV----TSPTVAADTASTLFSSLTD 579
Cdd:TIGR00864   78 SGCDEE--------YVAClkdnSSGGGAARSELVIFSAAHE 110
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 363-493 3.10e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 363 FTLEMLHLGNNRIE---VLEEGSFMNLTRLQklyLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKEILPGTFNPMPKLKV 439
Cdd:PLN00113 140 PNLETLDLSNNMLSgeiPNDIGSFSSLKVLD---LGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKW 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568987672 440 LYLN-NNLLQVLPAHI---------------FLG-IPLTRVNLKTNQFTHL-------PVSNILDDLDFLIQIDLEDN 493
Cdd:PLN00113 217 IYLGyNNLSGEIPYEIggltslnhldlvynnLTGpIPSSLGNLKNLQYLFLyqnklsgPIPPSIFSLQKLISLDLSDN 294
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-196 5.02e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 5.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  45 HLSLLNNGLTMLHTnDFSGLTNALSIHLGFNNIADIeTGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 124
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987672 125 ITIIePSAFSKLNRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 196
Cdd:COG4886  217 LTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-190 5.49e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 5.49e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  46 LSLLNNGLTMLhTNDFSGLTNALSIHLGFNNIADIETgAFNGLGLLKQLHINHNSLEILKEDtFHGLENLEFLQADNNFI 125
Cdd:COG4886  118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568987672 126 TIIePSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIgRILDL 190
Cdd:COG4886  195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL-EELDL 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
365-493 2.91e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 365 LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLNKGmFLGLHSLEYLYLEYNAVKEIlPGTFNPMPKLKVLYLNN 444
Cdd:COG4886  115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568987672 445 NLLQVLPAHIFLGIPLTRVNLKTNQFTHLPVSniLDDLDFLIQIDLEDN 493
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
364-421 4.16e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 4.16e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568987672  364 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYN 421
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
387-447 1.68e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.93  E-value: 1.68e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568987672  387 TRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLL 447
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 321-494 9.18e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 9.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 321 IHCQERNIESLSDLQPPPhNPRKLILAGNIIHTLmkSDLTDYFTLEMLHLGNNRIEVLEegSFMNLTRLQKLYLNGNHLT 400
Cdd:cd21340    7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 401 KLnKGmFLGLHSLEYLYLEYNAVKEILPGTFNPM------PKLKVLYL-NNNL-----LQVLPAhiflgipLTRVNLKTN 468
Cdd:cd21340   82 VV-EG-LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNIsGNNIdslepLAPLRN-------LEQLDASNN 152

                        170       180
                 ....*....|....*....|....*..
gi 568987672 469 QFTHL-PVSNILDDLDFLIQIDLEDNP 494
Cdd:cd21340  153 QISDLeELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
69-123 2.03e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.03e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568987672   69 SIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 123
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
20-176 6.32e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 6.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  20 IMIINCEEKGINKLSQISVPPSRPFHLSLLNNGLTMLHTNDFSGLTNALSIHLGFNNIADIETGAFNGLGLLKQLHinhn 99
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT---- 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568987672 100 SLEILKEDTFHGLENLEFLQADNNFITIIePSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLP 176
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175
LRR_8 pfam13855
Leucine rich repeat;
91-149 2.37e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.37e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568987672   91 LKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITIIEPSAFSKLNRLKVLILNDNAI 149
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
114-172 3.44e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.44e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  114 NLEFLQADNNFITIIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQL 172
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
342-399 2.44e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.44e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568987672  342 RKLILAGNIIHTLMKSDLTDYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 399
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-592 4.56e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 4.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  72 LGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNfitiiepSAFSKLNRLKVLILNDNAIES 151
Cdd:COG4886   55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 152 LPPNIFRFVPLTHLDLRGNQLQTLPyvgflehigrildlqlednkwacncellqlknwlenmppqsiigdvicyspppfk 231
Cdd:COG4886  128 LPEELANLTNLKELDLSNNQLTDLP------------------------------------------------------- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 232 gSVLSRLKkesfcptppvyeehedpsgsllaitsstsdsrlsskntsilkqptkapglipyltkpstqlpvpycpipcnc 311
Cdd:COG4886  153 -EPLGNLT------------------------------------------------------------------------ 159

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 312 kvlspsgllihcqerNIESLSdlqppphnprkliLAGNIIHTLmKSDLTDYFTLEMLHLGNNRIEVLEEgSFMNLTRLQK 391
Cdd:COG4886  160 ---------------NLKSLD-------------LSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEE 209

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 392 LYLNGNHLTKLNKGmFLGLHSLEYLYLEYNAVKEiLPGTFNpMPKLKVLYLNNNLLQVLPAHIFLGiPLTRVNLKTNQFT 471
Cdd:COG4886  210 LDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTD-LPELGN-LTNLEELDLSNNQLTDLPPLANLT-NLKTLDLSNNQLT 285

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 472 HLPVSNiLDDLDFLIQIDLEDNPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCPGLVNNPSM 551
Cdd:COG4886  286 DLKLKE-LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|.
gi 568987672 552 PTQTTYVIVTSPTVAADTASTLFSSLTDAVPLSVLILGLLI 592
Cdd:COG4886  365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-196 1.44e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  45 HLSLLNNGLTMLHtNDFSGLTNALSIHLGFNNIADIETgAFNGLGLLKQLHINHNSLEILKEdtFHGLENLEFLQADNNF 124
Cdd:COG4886  186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQ 261

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987672 125 ITIIEPSAfsKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNK 196
Cdd:COG4886  262 LTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-176 1.49e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  45 HLSLLNNGLTMLhtNDFSGLTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLE-----ILKEDTFHGL-ENLEFL 118
Cdd:cd21340   50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVL 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987672 119 QADNNFITIIEPsaFSKLNRLKVLILNDNAIESLPpNIFRFVP----LTHLDLRGNQLQTLP 176
Cdd:cd21340  126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLE-ELLDLLSswpsLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
412-470 5.16e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.16e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  412 SLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLLQVLPAHIFLGIP-LTRVNLKTNQF 470
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
493-543 1.16e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.19  E-value: 1.16e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568987672   493 NPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCP 543
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-196 1.17e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  45 HLSLLNNGLTMLhtNDFSGLTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLEILkeDTFHGLENLEFLQADNNF 124
Cdd:cd21340    6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 125 ITIIEpsAFSKLNRLKVLILNDNAIEslPPNIFRFVP---------LTHLDLRGNQLQTLPYVGFLEHIgRILDlqLEDN 195
Cdd:cd21340   80 ISVVE--GLENLTNLEELHIENQRLP--PGEKLTFDPrslaalsnsLRVLNISGNNIDSLEPLAPLRNL-EQLD--ASNN 152


                 .
gi 568987672 196 K 196
Cdd:cd21340  153 Q 153
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 75-170 1.71e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.84  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672   75 NNIADIETGAFNGLGLLKQLHINhNSLEILKEDTFHG--LENLEFlqadNNFITIIEPSAFSKLNRLKVLILNDNaIESL 152
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNcsLTSITI----PSSLTSIGEYAFSNCSNLKSITLPSN-LTSI 93

                          90
                  ....*....|....*...
gi 568987672  153 PPNIFRFVPLTHLDLRGN 170
Cdd:pfam13306  94 GSYAFSNCSLKSITIPSS 111
LRR_8 pfam13855
Leucine rich repeat;
46-101 2.25e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568987672   46 LSLLNNGLTMLHTNDFSGLTNALSIHLGFNNIADIETGAFNGLGLLKQLHINHNSL 101
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
138-196 7.89e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 7.89e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672  138 RLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQLQTLPYVGFlEHIGRILDLQLEDNK 196
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSPGAF-SGLPSLRYLDLSGNR 60
LRRCT smart00082
Leucine rich repeat C-terminal domain;
195-245 1.18e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.41  E-value: 1.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568987672   195 NKWACNCELLQLKNWLEN--MPPQSiiGDVICYSPPPFKGSVLSRLKKESFCP 245
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 464-579 1.40e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.38  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672   464 NLKTNQFTHLPvSNILDDLDFLIQIDLEDNPWDCSCDLVGLQQWIHKLG-KGTMTDDILCTSPGHLDKKELkaLNSDLLC 542
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGvKVRQPEAALCAGPGALAGQPL--LGIPLLD 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 568987672   543 PGLVNNpsmptqttYVIV----TSPTVAADTASTLFSSLTD 579
Cdd:TIGR00864   78 SGCDEE--------YVAClkdnSSGGGAARSELVIFSAAHE 110
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 363-493 3.10e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 363 FTLEMLHLGNNRIE---VLEEGSFMNLTRLQklyLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKEILPGTFNPMPKLKV 439
Cdd:PLN00113 140 PNLETLDLSNNMLSgeiPNDIGSFSSLKVLD---LGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKW 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568987672 440 LYLN-NNLLQVLPAHI---------------FLG-IPLTRVNLKTNQFTHL-------PVSNILDDLDFLIQIDLEDN 493
Cdd:PLN00113 217 IYLGyNNLSGEIPYEIggltslnhldlvynnLTGpIPSSLGNLKNLQYLFLyqnklsgPIPPSIFSLQKLISLDLSDN 294
LRR_8 pfam13855
Leucine rich repeat;
435-494 5.28e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 5.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568987672  435 PKLKVLYLNNNLLQVLPAHIFLGIP-LTRVNLKTNQFTHLPvSNILDDLDFLIQIDLEDNP 494
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 346-471 9.20e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 9.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987672 346 LAGNIIHTLmkSDLTDyftLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKE 425
Cdd:PLN00113 248 LTGPIPSSL--GNLKN---LQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTG 322

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568987672 426 ILPGTFNPMPKLKVLYL-NNNLLQVLPAHIFLGIPLTRVNLKTNQFT 471
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLwSNKFSGEIPKNLGKHNNLTVLDLSTNNLT 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH