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Conserved domains on  [gi|568987779|ref|XP_006519124|]
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capping protein, Arp2/3 and myosin-I linker protein 3 isoform X19 [Mus musculus]

Protein Classification

CARMIL family protein( domain architecture ID 11240132)

CARMIL family protein such as capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2), a cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 91-379 2.80e-82

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


:

Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 262.79  E-value: 2.80e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987779   91 TQELCPVAMRVAEGHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVVTYLTNSIVDEILQELYHSHKSLA 170
Cdd:pfam16000   1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987779  171 RHLTQL-RTLSDPPGG-ASQGQDPSSRGRGRNHDHE-ETDDELGTNIDTMAIKKQKR-CRKIRPVSAFISGSPQDMESQL 246
Cdd:pfam16000  81 RHLSQRgRTLLEPESLpDGDRPESSPLGPGKRHEGEiERLEELETPMATLKSKRKSIhSRKLRPVSVAFSVSELDLDKAP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987779  247 GSLGI--------PPGWFSGLGASQTTASGSWEGLSELPTHGYKLRHQTQgRPRPPRTTPPGPGRPSQVPVPGPRQENGM 318
Cdd:pfam16000 161 EEVPIhvedassgPPLPSSSPSEPELSASESLDSLSELPTEGQKLQHLTK-GRPKRNKTRAPTRPPGKVGPAQDGEQNGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987779  319 ATRLDEGLEDFFSRRVMDEssSYPRTLRTMRPGLSE-PPLPPLQKKRRRGLFHFRRPRSFKG 379
Cdd:pfam16000 240 SGRVDEGLEDFFSKKVIKL--STPTSPTSEPSSSSLfPDSPKKRKKRKSGFFNFIKPRSSKG 299
 
Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 91-379 2.80e-82

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 262.79  E-value: 2.80e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987779   91 TQELCPVAMRVAEGHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVVTYLTNSIVDEILQELYHSHKSLA 170
Cdd:pfam16000   1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987779  171 RHLTQL-RTLSDPPGG-ASQGQDPSSRGRGRNHDHE-ETDDELGTNIDTMAIKKQKR-CRKIRPVSAFISGSPQDMESQL 246
Cdd:pfam16000  81 RHLSQRgRTLLEPESLpDGDRPESSPLGPGKRHEGEiERLEELETPMATLKSKRKSIhSRKLRPVSVAFSVSELDLDKAP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987779  247 GSLGI--------PPGWFSGLGASQTTASGSWEGLSELPTHGYKLRHQTQgRPRPPRTTPPGPGRPSQVPVPGPRQENGM 318
Cdd:pfam16000 161 EEVPIhvedassgPPLPSSSPSEPELSASESLDSLSELPTEGQKLQHLTK-GRPKRNKTRAPTRPPGKVGPAQDGEQNGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987779  319 ATRLDEGLEDFFSRRVMDEssSYPRTLRTMRPGLSE-PPLPPLQKKRRRGLFHFRRPRSFKG 379
Cdd:pfam16000 240 SGRVDEGLEDFFSKKVIKL--STPTSPTSEPSSSSLfPDSPKKRKKRKSGFFNFIKPRSSKG 299
 
Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 91-379 2.80e-82

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 262.79  E-value: 2.80e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987779   91 TQELCPVAMRVAEGHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVVTYLTNSIVDEILQELYHSHKSLA 170
Cdd:pfam16000   1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987779  171 RHLTQL-RTLSDPPGG-ASQGQDPSSRGRGRNHDHE-ETDDELGTNIDTMAIKKQKR-CRKIRPVSAFISGSPQDMESQL 246
Cdd:pfam16000  81 RHLSQRgRTLLEPESLpDGDRPESSPLGPGKRHEGEiERLEELETPMATLKSKRKSIhSRKLRPVSVAFSVSELDLDKAP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987779  247 GSLGI--------PPGWFSGLGASQTTASGSWEGLSELPTHGYKLRHQTQgRPRPPRTTPPGPGRPSQVPVPGPRQENGM 318
Cdd:pfam16000 161 EEVPIhvedassgPPLPSSSPSEPELSASESLDSLSELPTEGQKLQHLTK-GRPKRNKTRAPTRPPGKVGPAQDGEQNGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987779  319 ATRLDEGLEDFFSRRVMDEssSYPRTLRTMRPGLSE-PPLPPLQKKRRRGLFHFRRPRSFKG 379
Cdd:pfam16000 240 SGRVDEGLEDFFSKKVIKL--STPTSPTSEPSSSSLfPDSPKKRKKRKSGFFNFIKPRSSKG 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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