|
Name |
Accession |
Description |
Interval |
E-value |
| Glyco_transf_24 super family |
cl39742 |
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein ... |
1220-1417 |
3.79e-147 |
|
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
The actual alignment was detected with superfamily member pfam18404:
Pssm-ID: 436473 Cd Length: 268 Bit Score: 447.83 E-value: 3.79e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1220 NIFSVASGHLYERFLRIMMLSVLRNTETPVKFWFLKNYLSPTFKEVIPHMAKEYGFQYELVQYKWPHWLHQQTDKQRIIW 1299
Cdd:pfam18404 2 NIFSVASGHLYERFLKIMMLSVRKNTKSPVKFWFIENFLSPSFKAFLPHLAKEYGFEYELVTYKWPSWLRKQTEKQRIIW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1300 GYKILFLDVLFPLAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPFCDSRTEMDGYRFWKTGYWASHLVKRKYHISA 1379
Cdd:pfam18404 82 GYKILFLDVLFPLDLDKVIFVDADQVVRTDLKELVDMDLEGAPYGYTPMCDSRKEMEGFRFWKQGYWKDHLRGRPYHISA 161
|
170 180 190
....*....|....*....|....*....|....*...
gi 568988427 1380 LYVVDLKKFRRISAGDRLRGQYQALSQDPNSLSNLDQD 1417
Cdd:pfam18404 162 LYVVDLKRFRQMAAGDRLRSHYQQLSADPNSLANLDQD 199
|
|
| Thioredoxin_12 |
pfam18400 |
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in ... |
36-217 |
9.96e-67 |
|
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
:
Pssm-ID: 465748 Cd Length: 187 Bit Score: 223.27 E-value: 9.96e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 36 ETPLLLEASEFMAEESNEKFWQFVETVRELAVY-KQTESDYSYYNLILKKAGQFLDNIHINLLKFAFSIRAYSPTIQMFQ 114
Cdd:pfam18400 1 ATPLLLEALETLAEENPDLFFPFLDALTNLDGEfADASTDEELYEAALKLASDHLSPLALSLFKLALSLRSASPRIEAFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 115 QMAAD----EPPPEGCTAFVVIHTKCTCKVNEIKKLL-NKAVSRPRPYLFERDHKFPTSSDnLPVIVLYAEIGTRAFAEF 189
Cdd:pfam18400 81 QIYAEsvsfEGAPPECDSWVDWGGEVYCDPEDLDALLkSEASSRPQPELLPFDHVYPDSGS-SPVAILYADLGSPNFREF 159
|
170 180
....*....|....*....|....*...
gi 568988427 190 HRVLSKKSKNGKILYVLRHYIQKPSSRK 217
Cdd:pfam18400 160 HKYLSELAKDGKIRYVLRHVPPSGSESK 187
|
|
| Thioredoxin_14 |
pfam18402 |
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in ... |
428-676 |
2.11e-57 |
|
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
:
Pssm-ID: 465750 Cd Length: 248 Bit Score: 199.04 E-value: 2.11e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 428 LDIRHS-----SIVWINDLENDGLYIDWPSSCWEFLKPVLHGTVPSVRRNFHNLVLFIDPAQ-EYTLDFINLAEFFYFNE 501
Cdd:pfam18402 1 FDIRDRiegggVIIWLNDLEKDKRYSRWPSSLQELLRPTYPGQLPPIRKNLFNLVLVVDLSQpEDLLLLVETLQSFVQRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 502 IPLRIGFVFILNvdnevdgTTDAGVALWRAFNYIEEKYDVSEAFISMTH-MYQEVKGHRILTVDEVKSILQNKCPHADIL 580
Cdd:pfam18402 81 IPVRFGLVPLVN-------STEDGLAQAKLFYYLLENYGLKAALSFLTAsLYALAKKVLSPTKAIFSSALKERTLRPQAL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 581 DILGI--HSKYDGRRMEGATFYKMTGLGPL--PQALyNGEPFDLKEmNTEElkgAVLEKMVGTFVDLQRDVFMGTIRDET 656
Cdd:pfam18402 154 SFDEVlkSEVYDERLKKAKEYLKRLGLDSLsgPVFV-NGVPLPRDE-NWLQ---ALSQRISEDLQLLQKAVYEGALTDDD 228
|
250 260
....*....|....*....|
gi 568988427 657 SAIDFLMDKSNVVSRLNSLI 676
Cdd:pfam18402 229 DVPDFFYDLPNALPRRNPLI 248
|
|
| Thioredoxin_15 |
pfam18403 |
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose: ... |
700-922 |
3.77e-57 |
|
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
:
Pssm-ID: 465751 Cd Length: 205 Bit Score: 196.68 E-value: 3.77e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 700 TFSFLDSQdkSAVIAKHMHYVTQEDAVISPVTLWIIADFDVPSGRKLLFNALKHMETSFHSRLGIVYNPTSKiNEESTVI 779
Cdd:pfam18403 1 DLNKLYSE--HADLFDKMPYLEASSDKEDWATLWVVADLDSESGRKLLLSALEFRKSNPGVRLGIIHNPASP-SEASSLI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 780 SRGILAAFLTHKNKHLRSFLRRLAEEETAEAIYSGdkvqtflavemdknafeKKYNTVGVNIFRTHQLFCQdVLKLRPGE 859
Cdd:pfam18403 78 SSALLAALLKLKNLDALEFLTKLLEEEEAAASESG-----------------KSSAEAAADYWKALQPFLR-VLGLKPGQ 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568988427 860 PGIISNGKFLGPL--SDELYQEDFHLLEKITFSNSLQNIAGIVESMDMNSK-HMSDLVMKIDGLMS 922
Cdd:pfam18403 140 NALVLNGRVVGPIpeDEEFSADDFELLLSYERSKRIEPVYKAIEELGLEDKiSDPDAVAKLTSLVA 205
|
|
| UDP-g_GGTase |
pfam06427 |
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded ... |
1083-1189 |
6.73e-52 |
|
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded beta-sandwiches found in UDP-glucose-glycoprotein glucosyltransferase-like proteins. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.
:
Pssm-ID: 461910 Cd Length: 109 Bit Score: 177.68 E-value: 6.73e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1083 GHCFDMTTEQPPQGLQFTLGTRSNPVVVDTIVMANLGYFQLKANPGAWILKLREGKSEDIYEITGHEGAE-PETNVGNVI 1161
Cdd:pfam06427 2 GHARDVTTGSPPRGLQLVLGTEKNPHVADTIVMANLGYFQLKANPGVWKLELREGRSSDIYEIESVGAEGwPSPGDEGTE 81
|
90 100
....*....|....*....|....*...
gi 568988427 1162 VVLNTFKSKILKIQVKKKSGKIQEDVLA 1189
Cdd:pfam06427 82 VALTSFEGLTLYPRLSRKPGMENEDVLE 109
|
|
| Thioredoxin_13 |
pfam18401 |
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found ... |
287-394 |
1.49e-35 |
|
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
:
Pssm-ID: 465749 Cd Length: 136 Bit Score: 131.92 E-value: 1.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 287 ESSKEMTPLKVWELQDLSFQAATQIVSTPvyDAIKLMKDISQNFPVKARTLTRIAVNELMRKEIQENQKDLrdrfeIKPG 366
Cdd:pfam18401 1 EEVEDLKPLSVWELQDLGLQAAQFIMSSD--DPLDTLLKLSQDFPKYASSLARHNVSDELREEIEENQERL-----LPPG 73
|
90 100
....*....|....*....|....*...
gi 568988427 367 DARLFINGLRVDVDVYDPFSILDMLKSE 394
Cdd:pfam18401 74 DNALWLNGLQLDERDIDPFSLLDILRRE 101
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Glyco_transf_24 |
pfam18404 |
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein ... |
1220-1417 |
3.79e-147 |
|
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
Pssm-ID: 436473 Cd Length: 268 Bit Score: 447.83 E-value: 3.79e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1220 NIFSVASGHLYERFLRIMMLSVLRNTETPVKFWFLKNYLSPTFKEVIPHMAKEYGFQYELVQYKWPHWLHQQTDKQRIIW 1299
Cdd:pfam18404 2 NIFSVASGHLYERFLKIMMLSVRKNTKSPVKFWFIENFLSPSFKAFLPHLAKEYGFEYELVTYKWPSWLRKQTEKQRIIW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1300 GYKILFLDVLFPLAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPFCDSRTEMDGYRFWKTGYWASHLVKRKYHISA 1379
Cdd:pfam18404 82 GYKILFLDVLFPLDLDKVIFVDADQVVRTDLKELVDMDLEGAPYGYTPMCDSRKEMEGFRFWKQGYWKDHLRGRPYHISA 161
|
170 180 190
....*....|....*....|....*....|....*...
gi 568988427 1380 LYVVDLKKFRRISAGDRLRGQYQALSQDPNSLSNLDQD 1417
Cdd:pfam18404 162 LYVVDLKRFRQMAAGDRLRSHYQQLSADPNSLANLDQD 199
|
|
| GT8_HUGT1_C_like |
cd06432 |
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain ... |
1219-1417 |
2.15e-142 |
|
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
Pssm-ID: 133054 Cd Length: 248 Bit Score: 434.51 E-value: 2.15e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1219 LNIFSVASGHLYERFLRIMMLSVLRNTETPVKFWFLKNYLSPTFKEVIPHMAKEYGFQYELVQYKWPHWLHQQTDKQRII 1298
Cdd:cd06432 1 INIFSVASGHLYERFLRIMMLSVMKNTKSPVKFWFIKNFLSPQFKEFLPEMAKEYGFEYELVTYKWPRWLHKQTEKQRII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1299 WGYKILFLDVLFPLAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPFCDSRTEMDGYRFWKTGYWASHLVKRKYHIS 1378
Cdd:cd06432 81 WGYKILFLDVLFPLNVDKVIFVDADQIVRTDLKELMDMDLKGAPYGYTPFCDSRKEMDGFRFWKQGYWKSHLRGRPYHIS 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 568988427 1379 ALYVVDLKKFRRISAGDRLRGQYQALSQDPNSLSNLDQD 1417
Cdd:cd06432 161 ALYVVDLKRFRRIAAGDRLRGQYQQLSQDPNSLANLDQD 199
|
|
| Thioredoxin_12 |
pfam18400 |
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in ... |
36-217 |
9.96e-67 |
|
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465748 Cd Length: 187 Bit Score: 223.27 E-value: 9.96e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 36 ETPLLLEASEFMAEESNEKFWQFVETVRELAVY-KQTESDYSYYNLILKKAGQFLDNIHINLLKFAFSIRAYSPTIQMFQ 114
Cdd:pfam18400 1 ATPLLLEALETLAEENPDLFFPFLDALTNLDGEfADASTDEELYEAALKLASDHLSPLALSLFKLALSLRSASPRIEAFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 115 QMAAD----EPPPEGCTAFVVIHTKCTCKVNEIKKLL-NKAVSRPRPYLFERDHKFPTSSDnLPVIVLYAEIGTRAFAEF 189
Cdd:pfam18400 81 QIYAEsvsfEGAPPECDSWVDWGGEVYCDPEDLDALLkSEASSRPQPELLPFDHVYPDSGS-SPVAILYADLGSPNFREF 159
|
170 180
....*....|....*....|....*...
gi 568988427 190 HRVLSKKSKNGKILYVLRHYIQKPSSRK 217
Cdd:pfam18400 160 HKYLSELAKDGKIRYVLRHVPPSGSESK 187
|
|
| Thioredoxin_14 |
pfam18402 |
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in ... |
428-676 |
2.11e-57 |
|
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465750 Cd Length: 248 Bit Score: 199.04 E-value: 2.11e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 428 LDIRHS-----SIVWINDLENDGLYIDWPSSCWEFLKPVLHGTVPSVRRNFHNLVLFIDPAQ-EYTLDFINLAEFFYFNE 501
Cdd:pfam18402 1 FDIRDRiegggVIIWLNDLEKDKRYSRWPSSLQELLRPTYPGQLPPIRKNLFNLVLVVDLSQpEDLLLLVETLQSFVQRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 502 IPLRIGFVFILNvdnevdgTTDAGVALWRAFNYIEEKYDVSEAFISMTH-MYQEVKGHRILTVDEVKSILQNKCPHADIL 580
Cdd:pfam18402 81 IPVRFGLVPLVN-------STEDGLAQAKLFYYLLENYGLKAALSFLTAsLYALAKKVLSPTKAIFSSALKERTLRPQAL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 581 DILGI--HSKYDGRRMEGATFYKMTGLGPL--PQALyNGEPFDLKEmNTEElkgAVLEKMVGTFVDLQRDVFMGTIRDET 656
Cdd:pfam18402 154 SFDEVlkSEVYDERLKKAKEYLKRLGLDSLsgPVFV-NGVPLPRDE-NWLQ---ALSQRISEDLQLLQKAVYEGALTDDD 228
|
250 260
....*....|....*....|
gi 568988427 657 SAIDFLMDKSNVVSRLNSLI 676
Cdd:pfam18402 229 DVPDFFYDLPNALPRRNPLI 248
|
|
| Thioredoxin_15 |
pfam18403 |
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose: ... |
700-922 |
3.77e-57 |
|
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465751 Cd Length: 205 Bit Score: 196.68 E-value: 3.77e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 700 TFSFLDSQdkSAVIAKHMHYVTQEDAVISPVTLWIIADFDVPSGRKLLFNALKHMETSFHSRLGIVYNPTSKiNEESTVI 779
Cdd:pfam18403 1 DLNKLYSE--HADLFDKMPYLEASSDKEDWATLWVVADLDSESGRKLLLSALEFRKSNPGVRLGIIHNPASP-SEASSLI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 780 SRGILAAFLTHKNKHLRSFLRRLAEEETAEAIYSGdkvqtflavemdknafeKKYNTVGVNIFRTHQLFCQdVLKLRPGE 859
Cdd:pfam18403 78 SSALLAALLKLKNLDALEFLTKLLEEEEAAASESG-----------------KSSAEAAADYWKALQPFLR-VLGLKPGQ 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568988427 860 PGIISNGKFLGPL--SDELYQEDFHLLEKITFSNSLQNIAGIVESMDMNSK-HMSDLVMKIDGLMS 922
Cdd:pfam18403 140 NALVLNGRVVGPIpeDEEFSADDFELLLSYERSKRIEPVYKAIEELGLEDKiSDPDAVAKLTSLVA 205
|
|
| UDP-g_GGTase |
pfam06427 |
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded ... |
1083-1189 |
6.73e-52 |
|
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded beta-sandwiches found in UDP-glucose-glycoprotein glucosyltransferase-like proteins. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.
Pssm-ID: 461910 Cd Length: 109 Bit Score: 177.68 E-value: 6.73e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1083 GHCFDMTTEQPPQGLQFTLGTRSNPVVVDTIVMANLGYFQLKANPGAWILKLREGKSEDIYEITGHEGAE-PETNVGNVI 1161
Cdd:pfam06427 2 GHARDVTTGSPPRGLQLVLGTEKNPHVADTIVMANLGYFQLKANPGVWKLELREGRSSDIYEIESVGAEGwPSPGDEGTE 81
|
90 100
....*....|....*....|....*...
gi 568988427 1162 VVLNTFKSKILKIQVKKKSGKIQEDVLA 1189
Cdd:pfam06427 82 VALTSFEGLTLYPRLSRKPGMENEDVLE 109
|
|
| Thioredoxin_13 |
pfam18401 |
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found ... |
287-394 |
1.49e-35 |
|
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465749 Cd Length: 136 Bit Score: 131.92 E-value: 1.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 287 ESSKEMTPLKVWELQDLSFQAATQIVSTPvyDAIKLMKDISQNFPVKARTLTRIAVNELMRKEIQENQKDLrdrfeIKPG 366
Cdd:pfam18401 1 EEVEDLKPLSVWELQDLGLQAAQFIMSSD--DPLDTLLKLSQDFPKYASSLARHNVSDELREEIEENQERL-----LPPG 73
|
90 100
....*....|....*....|....*...
gi 568988427 367 DARLFINGLRVDVDVYDPFSILDMLKSE 394
Cdd:pfam18401 74 DNALWLNGLQLDERDIDPFSLLDILRRE 101
|
|
| RfaJ |
COG1442 |
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ... |
1216-1417 |
1.05e-12 |
|
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441051 [Multi-domain] Cd Length: 301 Bit Score: 70.39 E-value: 1.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1216 NDILNIFSVASGHlYERFLRIMMLSVLRNT-ETPVKFWFLKNYLSPTFKEVIPHMAKEYGFQYELVQYKwPHWLHQQTDK 1294
Cdd:COG1442 3 KNTINIVFAIDDN-YLPGLGVSIASLLENNpDRPYDFHILTDGLSDENKERLEALAAKYNVSIEFIDVD-DELLKDLPVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1295 QRIIWG--YKiLFLDVLFPLAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPfcdsrtemDGYRFWKTGYWASHL-- 1370
Cdd:COG1442 81 KHISKAtyYR-LLIPELLPDDYDKVLYLDADTLVLGDLSELWDIDLGGNLLAAVR--------DGTVTGSQKKRAKRLgl 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 568988427 1371 -VKRKYHISALYVVDLKKFRRISAGDRLrgqYQALSQDPNSLSNLDQD 1417
Cdd:COG1442 152 pDDDGYFNSGVLLINLKKWREENITEKA---LEFLKENPDKLKYPDQD 196
|
|
| PLN02870 |
PLN02870 |
Probable galacturonosyltransferase |
1304-1349 |
2.71e-03 |
|
Probable galacturonosyltransferase
Pssm-ID: 215468 [Multi-domain] Cd Length: 533 Bit Score: 42.23 E-value: 2.71e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 568988427 1304 LFLDVLFPlAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPFC 1349
Cdd:PLN02870 334 IYLPELFP-NLDKVVFLDDDVVIQRDLSPLWDIDLGGKVNGAVETC 378
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Glyco_transf_24 |
pfam18404 |
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein ... |
1220-1417 |
3.79e-147 |
|
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
Pssm-ID: 436473 Cd Length: 268 Bit Score: 447.83 E-value: 3.79e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1220 NIFSVASGHLYERFLRIMMLSVLRNTETPVKFWFLKNYLSPTFKEVIPHMAKEYGFQYELVQYKWPHWLHQQTDKQRIIW 1299
Cdd:pfam18404 2 NIFSVASGHLYERFLKIMMLSVRKNTKSPVKFWFIENFLSPSFKAFLPHLAKEYGFEYELVTYKWPSWLRKQTEKQRIIW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1300 GYKILFLDVLFPLAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPFCDSRTEMDGYRFWKTGYWASHLVKRKYHISA 1379
Cdd:pfam18404 82 GYKILFLDVLFPLDLDKVIFVDADQVVRTDLKELVDMDLEGAPYGYTPMCDSRKEMEGFRFWKQGYWKDHLRGRPYHISA 161
|
170 180 190
....*....|....*....|....*....|....*...
gi 568988427 1380 LYVVDLKKFRRISAGDRLRGQYQALSQDPNSLSNLDQD 1417
Cdd:pfam18404 162 LYVVDLKRFRQMAAGDRLRSHYQQLSADPNSLANLDQD 199
|
|
| GT8_HUGT1_C_like |
cd06432 |
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain ... |
1219-1417 |
2.15e-142 |
|
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
Pssm-ID: 133054 Cd Length: 248 Bit Score: 434.51 E-value: 2.15e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1219 LNIFSVASGHLYERFLRIMMLSVLRNTETPVKFWFLKNYLSPTFKEVIPHMAKEYGFQYELVQYKWPHWLHQQTDKQRII 1298
Cdd:cd06432 1 INIFSVASGHLYERFLRIMMLSVMKNTKSPVKFWFIKNFLSPQFKEFLPEMAKEYGFEYELVTYKWPRWLHKQTEKQRII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1299 WGYKILFLDVLFPLAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPFCDSRTEMDGYRFWKTGYWASHLVKRKYHIS 1378
Cdd:cd06432 81 WGYKILFLDVLFPLNVDKVIFVDADQIVRTDLKELMDMDLKGAPYGYTPFCDSRKEMDGFRFWKQGYWKSHLRGRPYHIS 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 568988427 1379 ALYVVDLKKFRRISAGDRLRGQYQALSQDPNSLSNLDQD 1417
Cdd:cd06432 161 ALYVVDLKRFRRIAAGDRLRGQYQQLSQDPNSLANLDQD 199
|
|
| Thioredoxin_12 |
pfam18400 |
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in ... |
36-217 |
9.96e-67 |
|
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465748 Cd Length: 187 Bit Score: 223.27 E-value: 9.96e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 36 ETPLLLEASEFMAEESNEKFWQFVETVRELAVY-KQTESDYSYYNLILKKAGQFLDNIHINLLKFAFSIRAYSPTIQMFQ 114
Cdd:pfam18400 1 ATPLLLEALETLAEENPDLFFPFLDALTNLDGEfADASTDEELYEAALKLASDHLSPLALSLFKLALSLRSASPRIEAFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 115 QMAAD----EPPPEGCTAFVVIHTKCTCKVNEIKKLL-NKAVSRPRPYLFERDHKFPTSSDnLPVIVLYAEIGTRAFAEF 189
Cdd:pfam18400 81 QIYAEsvsfEGAPPECDSWVDWGGEVYCDPEDLDALLkSEASSRPQPELLPFDHVYPDSGS-SPVAILYADLGSPNFREF 159
|
170 180
....*....|....*....|....*...
gi 568988427 190 HRVLSKKSKNGKILYVLRHYIQKPSSRK 217
Cdd:pfam18400 160 HKYLSELAKDGKIRYVLRHVPPSGSESK 187
|
|
| Glyco_transf_8 |
cd00505 |
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ... |
1219-1417 |
2.01e-60 |
|
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.
Pssm-ID: 132996 [Multi-domain] Cd Length: 246 Bit Score: 207.68 E-value: 2.01e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1219 LNIFSVASGHLYERFLRIMMLSVLRNTETPVKFWFLKNYLSPTFKEVIPHMAKEYGFQYELVQYKWPHWLHQQTD-KQRI 1297
Cdd:cd00505 1 IAIVIVATGDEYLRGAIVLMKSVLRHRTKPLRFHVLTNPLSDTFKAALDNLRKLYNFNYELIPVDILDSVDSEHLkRPIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1298 IWGYKILFLDVLFPlAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPFCDSRTEMDGYRfwktgYWASHLVKRKYHI 1377
Cdd:cd00505 81 IVTLTKLHLPNLVP-DYDKILYVDADILVLTDIDELWDTPLGGQELAAAPDPGDRREGKYYR-----QKRSHLAGPDYFN 154
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 568988427 1378 SALYVVDLKKFRR-ISAGDRLRGQYQALSqdpnSLSNLDQD 1417
Cdd:cd00505 155 SGVFVVNLSKERRnQLLKVALEKWLQSLS----SLSGGDQD 191
|
|
| Thioredoxin_14 |
pfam18402 |
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in ... |
428-676 |
2.11e-57 |
|
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465750 Cd Length: 248 Bit Score: 199.04 E-value: 2.11e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 428 LDIRHS-----SIVWINDLENDGLYIDWPSSCWEFLKPVLHGTVPSVRRNFHNLVLFIDPAQ-EYTLDFINLAEFFYFNE 501
Cdd:pfam18402 1 FDIRDRiegggVIIWLNDLEKDKRYSRWPSSLQELLRPTYPGQLPPIRKNLFNLVLVVDLSQpEDLLLLVETLQSFVQRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 502 IPLRIGFVFILNvdnevdgTTDAGVALWRAFNYIEEKYDVSEAFISMTH-MYQEVKGHRILTVDEVKSILQNKCPHADIL 580
Cdd:pfam18402 81 IPVRFGLVPLVN-------STEDGLAQAKLFYYLLENYGLKAALSFLTAsLYALAKKVLSPTKAIFSSALKERTLRPQAL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 581 DILGI--HSKYDGRRMEGATFYKMTGLGPL--PQALyNGEPFDLKEmNTEElkgAVLEKMVGTFVDLQRDVFMGTIRDET 656
Cdd:pfam18402 154 SFDEVlkSEVYDERLKKAKEYLKRLGLDSLsgPVFV-NGVPLPRDE-NWLQ---ALSQRISEDLQLLQKAVYEGALTDDD 228
|
250 260
....*....|....*....|
gi 568988427 657 SAIDFLMDKSNVVSRLNSLI 676
Cdd:pfam18402 229 DVPDFFYDLPNALPRRNPLI 248
|
|
| Thioredoxin_15 |
pfam18403 |
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose: ... |
700-922 |
3.77e-57 |
|
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465751 Cd Length: 205 Bit Score: 196.68 E-value: 3.77e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 700 TFSFLDSQdkSAVIAKHMHYVTQEDAVISPVTLWIIADFDVPSGRKLLFNALKHMETSFHSRLGIVYNPTSKiNEESTVI 779
Cdd:pfam18403 1 DLNKLYSE--HADLFDKMPYLEASSDKEDWATLWVVADLDSESGRKLLLSALEFRKSNPGVRLGIIHNPASP-SEASSLI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 780 SRGILAAFLTHKNKHLRSFLRRLAEEETAEAIYSGdkvqtflavemdknafeKKYNTVGVNIFRTHQLFCQdVLKLRPGE 859
Cdd:pfam18403 78 SSALLAALLKLKNLDALEFLTKLLEEEEAAASESG-----------------KSSAEAAADYWKALQPFLR-VLGLKPGQ 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568988427 860 PGIISNGKFLGPL--SDELYQEDFHLLEKITFSNSLQNIAGIVESMDMNSK-HMSDLVMKIDGLMS 922
Cdd:pfam18403 140 NALVLNGRVVGPIpeDEEFSADDFELLLSYERSKRIEPVYKAIEELGLEDKiSDPDAVAKLTSLVA 205
|
|
| UDP-g_GGTase |
pfam06427 |
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded ... |
1083-1189 |
6.73e-52 |
|
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded beta-sandwiches found in UDP-glucose-glycoprotein glucosyltransferase-like proteins. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.
Pssm-ID: 461910 Cd Length: 109 Bit Score: 177.68 E-value: 6.73e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1083 GHCFDMTTEQPPQGLQFTLGTRSNPVVVDTIVMANLGYFQLKANPGAWILKLREGKSEDIYEITGHEGAE-PETNVGNVI 1161
Cdd:pfam06427 2 GHARDVTTGSPPRGLQLVLGTEKNPHVADTIVMANLGYFQLKANPGVWKLELREGRSSDIYEIESVGAEGwPSPGDEGTE 81
|
90 100
....*....|....*....|....*...
gi 568988427 1162 VVLNTFKSKILKIQVKKKSGKIQEDVLA 1189
Cdd:pfam06427 82 VALTSFEGLTLYPRLSRKPGMENEDVLE 109
|
|
| Thioredoxin_13 |
pfam18401 |
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found ... |
287-394 |
1.49e-35 |
|
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465749 Cd Length: 136 Bit Score: 131.92 E-value: 1.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 287 ESSKEMTPLKVWELQDLSFQAATQIVSTPvyDAIKLMKDISQNFPVKARTLTRIAVNELMRKEIQENQKDLrdrfeIKPG 366
Cdd:pfam18401 1 EEVEDLKPLSVWELQDLGLQAAQFIMSSD--DPLDTLLKLSQDFPKYASSLARHNVSDELREEIEENQERL-----LPPG 73
|
90 100
....*....|....*....|....*...
gi 568988427 367 DARLFINGLRVDVDVYDPFSILDMLKSE 394
Cdd:pfam18401 74 DNALWLNGLQLDERDIDPFSLLDILRRE 101
|
|
| RfaJ |
COG1442 |
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ... |
1216-1417 |
1.05e-12 |
|
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441051 [Multi-domain] Cd Length: 301 Bit Score: 70.39 E-value: 1.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1216 NDILNIFSVASGHlYERFLRIMMLSVLRNT-ETPVKFWFLKNYLSPTFKEVIPHMAKEYGFQYELVQYKwPHWLHQQTDK 1294
Cdd:COG1442 3 KNTINIVFAIDDN-YLPGLGVSIASLLENNpDRPYDFHILTDGLSDENKERLEALAAKYNVSIEFIDVD-DELLKDLPVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1295 QRIIWG--YKiLFLDVLFPLAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPfcdsrtemDGYRFWKTGYWASHL-- 1370
Cdd:COG1442 81 KHISKAtyYR-LLIPELLPDDYDKVLYLDADTLVLGDLSELWDIDLGGNLLAAVR--------DGTVTGSQKKRAKRLgl 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 568988427 1371 -VKRKYHISALYVVDLKKFRRISAGDRLrgqYQALSQDPNSLSNLDQD 1417
Cdd:COG1442 152 pDDDGYFNSGVLLINLKKWREENITEKA---LEFLKENPDKLKYPDQD 196
|
|
| GT8_A4GalT_like |
cd04194 |
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ... |
1230-1417 |
3.06e-09 |
|
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.
Pssm-ID: 133037 [Multi-domain] Cd Length: 248 Bit Score: 59.15 E-value: 3.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1230 YERFLRIMMLSVLRNT-ETPVKFWFLKNYLSPTFKEVIPHMAKEYGFQYELVQYKWPHWLHQQTDKQRiiWGYKI---LF 1305
Cdd:cd04194 11 YAPYLAVTIKSILANNsKRDYDFYILNDDISEENKKKLKELLKKYNSSIEFIKIDNDDFKFFPATTDH--ISYATyyrLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988427 1306 LDVLFPlAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGytpfcdSRTEMDGYRFWKTGYWASHLVKRKYHISALYVVDL 1385
Cdd:cd04194 89 IPDLLP-DYDKVLYLDADIIVLGDLSELFDIDLGDNLLA------AVRDPFIEQEKKRKRRLGGYDDGSYFNSGVLLINL 161
|
170 180 190
....*....|....*....|....*....|..
gi 568988427 1386 KKFRRISAGDRLrgqYQALSQDPNSLSNLDQD 1417
Cdd:cd04194 162 KKWREENITEKL---LELIKEYGGRLIYPDQD 190
|
|
| PLN02870 |
PLN02870 |
Probable galacturonosyltransferase |
1304-1349 |
2.71e-03 |
|
Probable galacturonosyltransferase
Pssm-ID: 215468 [Multi-domain] Cd Length: 533 Bit Score: 42.23 E-value: 2.71e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 568988427 1304 LFLDVLFPlAVDKVIFVDADQIVRHDLKELRDFDLGGAPYGYTPFC 1349
Cdd:PLN02870 334 IYLPELFP-NLDKVVFLDDDVVIQRDLSPLWDIDLGGKVNGAVETC 378
|
|
| |
