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Conserved domains on  [gi|568990966|ref|XP_006520315|]
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DENN domain-containing protein 3 isoform X1 [Mus musculus]

Protein Classification

DENN and dDENN domain-containing protein( domain architecture ID 12031393)

protein containing domains DENN, dDENN, and WD40

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 1-123 4.66e-45

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 160.82  E-value: 4.66e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966     1 MKPLQVVFPSRADPesPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVP 80
Cdd:pfam02141   66 TEPILLQRPEDSEL--PLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIP 143

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 568990966    81 ILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDHG 123
Cdd:pfam02141  144 VLPASLLDVLSAPTPFIIGVHSRYFDLLEDPLDDVVLVDLDTG 186
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 771-1024 2.25e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  771 HCFKVGSSKVNCMVMAEHNQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTG-LAVHNGKKpseIYSCSLDGTVIAWN 848
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  849 VSTLRVISRFQLSYGDLLSISLHNDR--IWCCTVHKILVV--TPQGFVRQELK-HPKDASFLAFqllPEEQQLWAASTGV 923
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVwdVETGKCLTTLRgHTDWVNSVAF---SPDGTFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  924 SELYMWSLKDLdqPPQKTYLQDCSEVTCMirvkrqIWVG-GRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSA 1002
Cdd:cd00200   157 GTIKLWDLRTG--KCVATLTGHTGEVNSV------AFSPdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFS 228

                         250       260
                  ....*....|....*....|..
gi 568990966 1003 EDRYVLSGAGqEEGKIAIWKVE 1024
Cdd:cd00200   229 PDGYLLASGS-EDGTIRVWDLR 249
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 187-249 4.67e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.00  E-value: 4.67e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568990966    187 NCKIQHITLQLLVGIFREVKNHLNY------EHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKAR 249
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 1-123 4.66e-45

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 160.82  E-value: 4.66e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966     1 MKPLQVVFPSRADPesPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVP 80
Cdd:pfam02141   66 TEPILLQRPEDSEL--PLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIP 143

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 568990966    81 ILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDHG 123
Cdd:pfam02141  144 VLPASLLDVLSAPTPFIIGVHSRYFDLLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 5-123 4.00e-42

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 152.35  E-value: 4.00e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966      5 QVVFPSRADPESPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSG 84
Cdd:smart00799   64 LIELQRPLDSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPA 143

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 568990966     85 QMLDFVMAPTSFLMGCHLDHFEEVRKEADG-LVLIDIDHG 123
Cdd:smart00799  144 SLLDVLSAPTPFIIGVHSSYFEEVKELPDEdVVVVDLDTG 183
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 771-1024 2.25e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  771 HCFKVGSSKVNCMVMAEHNQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTG-LAVHNGKKpseIYSCSLDGTVIAWN 848
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  849 VSTLRVISRFQLSYGDLLSISLHNDR--IWCCTVHKILVV--TPQGFVRQELK-HPKDASFLAFqllPEEQQLWAASTGV 923
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVwdVETGKCLTTLRgHTDWVNSVAF---SPDGTFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  924 SELYMWSLKDLdqPPQKTYLQDCSEVTCMirvkrqIWVG-GRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSA 1002
Cdd:cd00200   157 GTIKLWDLRTG--KCVATLTGHTGEVNSV------AFSPdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFS 228

                         250       260
                  ....*....|....*....|..
gi 568990966 1003 EDRYVLSGAGqEEGKIAIWKVE 1024
Cdd:cd00200   229 PDGYLLASGS-EDGTIRVWDLR 249
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 187-249 4.67e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.00  E-value: 4.67e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568990966    187 NCKIQHITLQLLVGIFREVKNHLNY------EHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKAR 249
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 COG2319
WD40 repeat [General function prediction only];
756-1024 7.52e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 7.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  756 GKVVVFDASSWTVHQHcFKVGSSKVNCMVM-AEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVH-NGKKps 833
Cdd:COG2319   142 GTVRLWDLATGKLLRT-LTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpDGKL-- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  834 eIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHND--RIWCCTVHKILVV--TPQGFVRQELKHPKDA-SFLAFq 908
Cdd:COG2319   219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLwdLATGELLRTLTGHSGGvNSVAF- 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  909 lLPEEQQLwAASTGVSELYMWSLKDldQPPQKTYLQDCSEVTCMI--RVKRQIWVGGRGlsqgktrGKIYVMDVEKVTVE 986
Cdd:COG2319   297 -SPDGKLL-ASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAfsPDGKTLASGSDD-------GTVRLWDLATGELL 365

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 568990966  987 KELVAHLDTVRTLC-SAEDRYVLSGAgqEEGKIAIWKVE 1024
Cdd:COG2319   366 RTLTGHTGAVTSVAfSPDGRTLASGS--ADGTVRLWDLA 402
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 216-251 1.11e-03

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 37.94  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568990966   216 FNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLN 251
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLE 36
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 807-848 2.13e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.13e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568990966    807 SMSCNKQLTDHRSPVTGLAVHNGKKpsEIYSCSLDGTVIAWN 848
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 1-123 4.66e-45

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 160.82  E-value: 4.66e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966     1 MKPLQVVFPSRADPesPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVP 80
Cdd:pfam02141   66 TEPILLQRPEDSEL--PLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIP 143

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 568990966    81 ILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDHG 123
Cdd:pfam02141  144 VLPASLLDVLSAPTPFIIGVHSRYFDLLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 5-123 4.00e-42

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 152.35  E-value: 4.00e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966      5 QVVFPSRADPESPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSG 84
Cdd:smart00799   64 LIELQRPLDSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPA 143

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 568990966     85 QMLDFVMAPTSFLMGCHLDHFEEVRKEADG-LVLIDIDHG 123
Cdd:smart00799  144 SLLDVLSAPTPFIIGVHSSYFEEVKELPDEdVVVVDLDTG 183
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 771-1024 2.25e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  771 HCFKVGSSKVNCMVMAEHNQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTG-LAVHNGKKpseIYSCSLDGTVIAWN 848
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  849 VSTLRVISRFQLSYGDLLSISLHNDR--IWCCTVHKILVV--TPQGFVRQELK-HPKDASFLAFqllPEEQQLWAASTGV 923
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVwdVETGKCLTTLRgHTDWVNSVAF---SPDGTFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  924 SELYMWSLKDLdqPPQKTYLQDCSEVTCMirvkrqIWVG-GRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSA 1002
Cdd:cd00200   157 GTIKLWDLRTG--KCVATLTGHTGEVNSV------AFSPdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFS 228

                         250       260
                  ....*....|....*....|..
gi 568990966 1003 EDRYVLSGAGqEEGKIAIWKVE 1024
Cdd:cd00200   229 PDGYLLASGS-EDGTIRVWDLR 249
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 187-249 4.67e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.00  E-value: 4.67e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568990966    187 NCKIQHITLQLLVGIFREVKNHLNY------EHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKAR 249
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 COG2319
WD40 repeat [General function prediction only];
756-1024 7.52e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 7.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  756 GKVVVFDASSWTVHQHcFKVGSSKVNCMVM-AEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVH-NGKKps 833
Cdd:COG2319   142 GTVRLWDLATGKLLRT-LTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpDGKL-- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  834 eIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHND--RIWCCTVHKILVV--TPQGFVRQELKHPKDA-SFLAFq 908
Cdd:COG2319   219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLwdLATGELLRTLTGHSGGvNSVAF- 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  909 lLPEEQQLwAASTGVSELYMWSLKDldQPPQKTYLQDCSEVTCMI--RVKRQIWVGGRGlsqgktrGKIYVMDVEKVTVE 986
Cdd:COG2319   297 -SPDGKLL-ASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAfsPDGKTLASGSDD-------GTVRLWDLATGELL 365

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 568990966  987 KELVAHLDTVRTLC-SAEDRYVLSGAgqEEGKIAIWKVE 1024
Cdd:COG2319   366 RTLTGHTGAVTSVAfSPDGRTLASGS--ADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
752-1024 1.24e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  752 ALNEGKVVVFDASSwTVHQHCFKVGSSKVNCMVMAEHNQVWV-GSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVH-NG 829
Cdd:COG2319    96 ASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLAsGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSpDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  830 KKpseIYSCSLDGTVIAWNVSTLRVISRFQlsygdllsisLHNDRIWCCTVH---KILVV-----------TPQGFVRQE 895
Cdd:COG2319   175 KL---LASGSDDGTVRLWDLATGKLLRTLT----------GHTGAVRSVAFSpdgKLLASgsadgtvrlwdLATGKLLRT 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  896 LKHPKDA-SFLAFqlLPEEQQLWAASTGvSELYMWSLKdlDQPPQKTYLQDCSEVTCMIRVK--RQIWVGGRGlsqgktr 972
Cdd:COG2319   242 LTGHSGSvRSVAF--SPDGRLLASGSAD-GTVRLWDLA--TGELLRTLTGHSGGVNSVAFSPdgKLLASGSDD------- 309

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568990966  973 GKIYVMDVEKVTVEKELVAHLDTVRTLC-SAEDRYVLSGAgqEEGKIAIWKVE 1024
Cdd:COG2319   310 GTVRLWDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGS--DDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
749-873 4.06e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 4.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  749 LWCALNEGKVVVFDASSWTVhQHCFKVGSSKVNCMVMAEHNQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVH 827
Cdd:COG2319   219 LASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSPDGRlLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 568990966  828 -NGKKpseIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHND 873
Cdd:COG2319   298 pDGKL---LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 780-848 7.18e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 7.18e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568990966  780 VNCmVMAEHNQVWV--GSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKpsEIYSCSLDGTVIAWN 848
Cdd:cd00200   222 VNS-VAFSPDGYLLasGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK--RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 793-881 8.22e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 8.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  793 VGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKpsEIYSCSLDGTVIAWNVSTLRVISRFQlsygdllsisLHN 872
Cdd:cd00200   194 SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY--LLASGSEDGTIRVWDLRTGECVQTLS----------GHT 261


                  ....*....
gi 568990966  873 DRIWCCTVH 881
Cdd:cd00200   262 NSVTSLAWS 270
WD40 COG2319
WD40 repeat [General function prediction only];
756-851 2.19e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568990966  756 GKVVVFDASSWTVhQHCFKVGSSKVNCMVMAEHNQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVH-NGKKps 833
Cdd:COG2319   310 GTVRLWDLATGKL-LRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpDGRT-- 386

                          90
                  ....*....|....*...
gi 568990966  834 eIYSCSLDGTVIAWNVST 851
Cdd:COG2319   387 -LASGSADGTVRLWDLAT 403
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 216-251 1.11e-03

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 37.94  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568990966   216 FNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLN 251
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLE 36
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 807-848 2.13e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.13e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568990966    807 SMSCNKQLTDHRSPVTGLAVHNGKKpsEIYSCSLDGTVIAWN 848
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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