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Conserved domains on  [gi|568991673|ref|XP_006520655|]
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platelet-derived growth factor subunit B isoform X2 [Mus musculus]

Protein Classification

PDGF domain-containing protein( domain architecture ID 10448475)

PDGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
34-117 4.24e-31

PDGF/VEGF domain;


:

Pssm-ID: 425620  Cd Length: 82  Bit Score: 107.76  E-value: 4.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991673   34 CKTRTEVFQISRNLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPIFKKATVTLEDHL 113
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 568991673  114 ACKC 117
Cdd:pfam00341  79 QCEC 82
 
Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
34-117 4.24e-31

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 107.76  E-value: 4.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991673   34 CKTRTEVFQISRNLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPIFKKATVTLEDHL 113
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 568991673  114 ACKC 117
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 32-119 2.25e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 95.95  E-value: 2.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991673    32 AECKTRTEVFQISRNLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMrpVQVRKIEIVRKKPIfKKATVTLED 111
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETN--FLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
gi 568991673   112 HLACKCET 119
Cdd:smart00141  76 HTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 32-119 1.29e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 91.28  E-value: 1.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991673  32 AECKTRTEVFQISRNLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRkKPIFKKATVTLED 111
Cdd:cd00135    1 SSCKPRETLVEISEELPDETN--TIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEE 77


                 ....*...
gi 568991673 112 HLACKCET 119
Cdd:cd00135   78 HTECECRP 85
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 34-137 1.21e-09

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 54.24  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991673  34 CKTRTEVFQISRNLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPIFKK-ATVTLEDH 112
Cdd:PHA02661  48 CQPRDTVVQLSDEYPGNTNDRYN--PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNfQTISVEEH 125

                         90       100
                 ....*....|....*....|....*
gi 568991673 113 LACKCETVVTPRPVTrspgTSREQR 137
Cdd:PHA02661 126 TKCKCEFKTTPPPTT----TTREPR 146
 
Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
34-117 4.24e-31

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 107.76  E-value: 4.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991673   34 CKTRTEVFQISRNLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPIFKKATVTLEDHL 113
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 568991673  114 ACKC 117
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 32-119 2.25e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 95.95  E-value: 2.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991673    32 AECKTRTEVFQISRNLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMrpVQVRKIEIVRKKPIfKKATVTLED 111
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETN--FLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
gi 568991673   112 HLACKCET 119
Cdd:smart00141  76 HTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 32-119 1.29e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 91.28  E-value: 1.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991673  32 AECKTRTEVFQISRNLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRkKPIFKKATVTLED 111
Cdd:cd00135    1 SSCKPRETLVEISEELPDETN--TIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEE 77


                 ....*...
gi 568991673 112 HLACKCET 119
Cdd:cd00135   78 HTECECRP 85
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 34-137 1.21e-09

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 54.24  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991673  34 CKTRTEVFQISRNLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPIFKK-ATVTLEDH 112
Cdd:PHA02661  48 CQPRDTVVQLSDEYPGNTNDRYN--PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNfQTISVEEH 125

                         90       100
                 ....*....|....*....|....*
gi 568991673 113 LACKCETVVTPRPVTrspgTSREQR 137
Cdd:PHA02661 126 TKCKCEFKTTPPPTT----TTREPR 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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