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Conserved domains on  [gi|568993318|ref|XP_006521452|]
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methyltransferase-like protein 7A isoform X1 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10549394)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Saccharomyces cerevisiae tRNA (carboxymethyluridine(34)-5-O)-methyltransferase

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-154 4.41e-24

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


:

Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 91.57  E-value: 4.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   57 LEVGCGTGANFK-FYPPGCRVTCIDPNPNFEKFlfksVAENRQLQFERFVVAAGEDMhQVTDGSVDVVVCTLVLCSVKNQ 135
Cdd:pfam08241   1 LDVGCGTGLLTElLARLGARVTGVDISPEMLEL----AREKAPREGLTFVVGDAEDL-PFPDNSFDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*....
gi 568993318  136 EKILREVCRVLKPGGAFYF 154
Cdd:pfam08241  76 ERALREIARVLKPGGILII 94
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-154 4.41e-24

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 91.57  E-value: 4.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   57 LEVGCGTGANFK-FYPPGCRVTCIDPNPNFEKFlfksVAENRQLQFERFVVAAGEDMhQVTDGSVDVVVCTLVLCSVKNQ 135
Cdd:pfam08241   1 LDVGCGTGLLTElLARLGARVTGVDISPEMLEL----AREKAPREGLTFVVGDAEDL-PFPDNSFDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*....
gi 568993318  136 EKILREVCRVLKPGGAFYF 154
Cdd:pfam08241  76 ERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 46-165 6.55e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 90.05  E-value: 6.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  46 EFAGPSGKLTLLEVGCGTGAN-FKFYPPGCRVTCIDPNPNFEKFLfKSVAENRQLQFErFVVAAGEDMHqVTDGSVDVVV 124
Cdd:COG2226   16 AALGLRPGARVLDLGCGTGRLaLALAERGARVTGVDISPEMLELA-RERAAEAGLNVE-FVVGDAEDLP-FPDGSFDLVI 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568993318 125 CTLVLCSVKNQEKILREVCRVLKPGGAFYFMEHVADERSTW 165
Cdd:COG2226   93 SSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAEL 133
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-155 1.75e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 72.08  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  55 TLLEVGCGTGANFKFY--PPGCRVTCIDPNPNFEKFLfKSVAENRQLQFERFVVAAGEDMHQVTDGSVDVVVCTLVL-CS 131
Cdd:cd02440    1 RVLDLGCGTGALALALasGPGARVTGVDISPVALELA-RKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLhHL 79

                         90       100
                 ....*....|....*....|....
gi 568993318 132 VKNQEKILREVCRVLKPGGAFYFM 155
Cdd:cd02440   80 VEDLARFLEEARRLLKPGGVLVLT 103
PRK08317 PRK08317
hypothetical protein; Provisional
 32-150 2.03e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 58.79  E-value: 2.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  32 QMASQKRELFSNLQEFAGPSGkltlLEVGCGTGaNFKFY-----PPGCRVTCIDPNPNFEKFlfksvAENRQLQ---FER 103
Cdd:PRK08317   3 DFRRYRARTFELLAVQPGDRV----LDVGCGPG-NDARElarrvGPEGRVVGIDRSEAMLAL-----AKERAAGlgpNVE 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568993318 104 FVVAAGEDMhQVTDGSVDVVVCTLVLCSVKNQEKILREVCRVLKPGG 150
Cdd:PRK08317  73 FVRGDADGL-PFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGG 118
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 37-156 5.46e-10

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 57.27  E-value: 5.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   37 KRELFSNLQEFAGPsgklTLLEVGCGTG----ANFKFYPPGCRVTCIDPNPNFEKflfksVAENRQLQFER--FVVAAGE 110
Cdd:TIGR01934  28 RRRAVKLIGVFKGQ----KVLDVACGTGdlaiELAKSAPDRGKVTGVDFSSEMLE-----VAKKKSELPLNieFIQADAE 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568993318  111 DMhQVTDGSVDVVVCTLVLCSVKNQEKILREVCRVLKPGGAFYFME 156
Cdd:TIGR01934  99 AL-PFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILE 143
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-154 4.41e-24

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 91.57  E-value: 4.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   57 LEVGCGTGANFK-FYPPGCRVTCIDPNPNFEKFlfksVAENRQLQFERFVVAAGEDMhQVTDGSVDVVVCTLVLCSVKNQ 135
Cdd:pfam08241   1 LDVGCGTGLLTElLARLGARVTGVDISPEMLEL----AREKAPREGLTFVVGDAEDL-PFPDNSFDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*....
gi 568993318  136 EKILREVCRVLKPGGAFYF 154
Cdd:pfam08241  76 ERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 46-165 6.55e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 90.05  E-value: 6.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  46 EFAGPSGKLTLLEVGCGTGAN-FKFYPPGCRVTCIDPNPNFEKFLfKSVAENRQLQFErFVVAAGEDMHqVTDGSVDVVV 124
Cdd:COG2226   16 AALGLRPGARVLDLGCGTGRLaLALAERGARVTGVDISPEMLELA-RERAAEAGLNVE-FVVGDAEDLP-FPDGSFDLVI 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568993318 125 CTLVLCSVKNQEKILREVCRVLKPGGAFYFMEHVADERSTW 165
Cdd:COG2226   93 SSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAEL 133
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 57-150 6.16e-19

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 78.37  E-value: 6.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   57 LEVGCGTGANFKFYPP--GCRVTCIDPNPNFEKFLfKSVAENRQLQFErFVVAAGEDMHqVTDGSVDVVVCTLVL--CSV 132
Cdd:pfam13649   2 LDLGCGTGRLTLALARrgGARVTGVDLSPEMLERA-RERAAEAGLNVE-FVQGDAEDLP-FPDGSFDLVVSSGVLhhLPD 78

                          90
                  ....*....|....*...
gi 568993318  133 KNQEKILREVCRVLKPGG 150
Cdd:pfam13649  79 PDLEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 38-155 1.24e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 75.82  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  38 RELFSNLQEFAGPSGKLtlLEVGCGTGAN-FKFYPPGCRVTCIDPNPNFEKflfksVAENRQLQFE-RFVVAAGEDMhQV 115
Cdd:COG2227   12 RRLAALLARLLPAGGRV--LDVGCGTGRLaLALARRGADVTGVDISPEALE-----IARERAAELNvDFVQGDLEDL-PL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568993318 116 TDGSVDVVVCTLVLCSVKNQEKILREVCRVLKPGGAFYFM 155
Cdd:COG2227   84 EDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLS 123
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-155 1.75e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 72.08  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  55 TLLEVGCGTGANFKFY--PPGCRVTCIDPNPNFEKFLfKSVAENRQLQFERFVVAAGEDMHQVTDGSVDVVVCTLVL-CS 131
Cdd:cd02440    1 RVLDLGCGTGALALALasGPGARVTGVDISPVALELA-RKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLhHL 79

                         90       100
                 ....*....|....*....|....
gi 568993318 132 VKNQEKILREVCRVLKPGGAFYFM 155
Cdd:cd02440   80 VEDLARFLEEARRLLKPGGVLVLT 103
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-150 1.80e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 72.02  E-value: 1.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   57 LEVGCGTGANFKF---YPPGCRVTCIDPNPNFEKFLFKSVAENRQLQFERfVVAAGEDMHQVTDGSVDVVVCTLVLCSVK 133
Cdd:pfam08242   1 LEIGCGTGTLLRAlleALPGLEYTGLDISPAALEAARERLAALGLLNAVR-VELFQLDLGELDPGSFDVVVASNVLHHLA 79

                          90
                  ....*....|....*..
gi 568993318  134 NQEKILREVCRVLKPGG 150
Cdd:pfam08242  80 DPRAVLRNIRRLLKPGG 96
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 29-199 1.55e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 68.61  E-value: 1.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   29 YNEQMAsqkRELFSNLQEFAG--PSGKlTLLEVGCGTGANFK-FYPPGCRVTCIDPNPNfekflfksvAENRQLQFERFV 105
Cdd:pfam13489   1 YAHQRE---RLLADLLLRLLPklPSPG-RVLDFGCGTGIFLRlLRAQGFSVTGVDPSPI---------AIERALLNVRFD 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  106 VAAgEDMHQVTDGSVDVVVCTLVLCSVKNQEKILREVCRVLKPGGAFYFMEHVADerstwnYFWQQVLDPVWFLFFDG-- 183
Cdd:pfam13489  68 QFD-EQEAAVPAGKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPLAS------DEADRLLLEWPYLRPRNgh 140

                         170
                  ....*....|....*...
gi 568993318  184 -CNLTRESWKTI-EQASF 199
Cdd:pfam13489 141 iSLFSARSLKRLlEEAGF 158
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 50-161 6.58e-14

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 66.67  E-value: 6.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   50 PSGKLTLLEVGCGTGA-NFKFYP---PGCRVTCIDpnpnFEKFLFKSVAEN-RQLQFERFVVAAG--EDM-HQVTDGSVD 121
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHlSFELAEelgPNAEVVGID----ISEEAIEKARENaQKLGFDNVEFEQGdiEELpELLEDDKFD 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568993318  122 VVVCTLVLCSVKNQEKILREVCRVLKPGGAFYFMEHVADE 161
Cdd:pfam13847  77 VVISNCVLNHIPDPDKVLQEILRVLKPGGRLIISDPDSLA 116
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
38-161 3.04e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 65.40  E-value: 3.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  38 RELFSNLQEFAGPSGKLTLLEVGCGTGANFKFYPP-GCRVTCIDPNPNFekfLfkSVAENRQLQfERFVVAageDMHQVT 116
Cdd:COG4976   32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPrGYRLTGVDLSEEM---L--AKAREKGVY-DRLLVA---DLADLA 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568993318 117 --DGSVDVVVCTLVLCSVKNQEKILREVCRVLKPGGAFYF-MEHVADE 161
Cdd:COG4976  103 epDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFsVEDADGS 150
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
55-154 8.03e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 62.15  E-value: 8.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  55 TLLEVGCGTGAN---FKFYPPGCRVTCIDPNPNFekflfksVAENRQLQFE-RFVVAageDMHQVT-DGSVDVVVCTLVL 129
Cdd:COG4106    4 RVLDLGCGTGRLtalLAERFPGARVTGVDLSPEM-------LARARARLPNvRFVVA---DLRDLDpPEPFDLVVSNAAL 73

                         90       100
                 ....*....|....*....|....*
gi 568993318 130 CSVKNQEKILREVCRVLKPGGAFYF 154
Cdd:COG4106   74 HWLPDHAALLARLAAALAPGGVLAV 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 44-154 2.27e-11

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 60.70  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  44 LQEFAGPSGKLTLLEVGCGTGANFKFY--PPGCRVTCIDPNPNFEKFLfKSVAENRQLQFERFVVAAGEDMHQVTDGSVD 121
Cdd:COG0500   18 LALLERLPKGGRVLDLGCGTGRNLLALaaRFGGRVIGIDLSPEAIALA-RARAAKAGLGNVEFLVADLAELDPLPAESFD 96

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568993318 122 VVVCTLVLCSV--KNQEKILREVCRVLKPGGAFYF 154
Cdd:COG0500   97 LVVAFGVLHHLppEEREALLRELARALKPGGVLLL 131
PRK08317 PRK08317
hypothetical protein; Provisional
 32-150 2.03e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 58.79  E-value: 2.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  32 QMASQKRELFSNLQEFAGPSGkltlLEVGCGTGaNFKFY-----PPGCRVTCIDPNPNFEKFlfksvAENRQLQ---FER 103
Cdd:PRK08317   3 DFRRYRARTFELLAVQPGDRV----LDVGCGPG-NDARElarrvGPEGRVVGIDRSEAMLAL-----AKERAAGlgpNVE 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568993318 104 FVVAAGEDMhQVTDGSVDVVVCTLVLCSVKNQEKILREVCRVLKPGG 150
Cdd:PRK08317  73 FVRGDADGL-PFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGG 118
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 37-156 5.46e-10

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 57.27  E-value: 5.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   37 KRELFSNLQEFAGPsgklTLLEVGCGTG----ANFKFYPPGCRVTCIDPNPNFEKflfksVAENRQLQFER--FVVAAGE 110
Cdd:TIGR01934  28 RRRAVKLIGVFKGQ----KVLDVACGTGdlaiELAKSAPDRGKVTGVDFSSEMLE-----VAKKKSELPLNieFIQADAE 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568993318  111 DMhQVTDGSVDVVVCTLVLCSVKNQEKILREVCRVLKPGGAFYFME 156
Cdd:TIGR01934  99 AL-PFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILE 143
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 55-154 6.38e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 56.09  E-value: 6.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  55 TLLEVGCGTGANFKF----YppGCRVTCIDPNPNfekflfksvaenrQLQF-ERFVVAAG---------EDMHQVT-DGS 119
Cdd:COG2230   54 RVLDIGCGWGGLALYlarrY--GVRVTGVTLSPE-------------QLEYaRERAAEAGladrvevrlADYRDLPaDGQ 118

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568993318 120 VDVVVCTLVLCSV--KNQEKILREVCRVLKPGGAFYF 154
Cdd:COG2230  119 FDAIVSIGMFEHVgpENYPAYFAKVARLLKPGGRLLL 155
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 32-204 1.41e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 53.44  E-value: 1.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   32 QMASQKRELFSNLQEFAGPSgkltLLEVGCGTG----ANFKFYPPGcRVTCIDPNPNFEKFLFKSVAENRQlqferFVVA 107
Cdd:TIGR02072  18 EMAKRLLALLKEKGIFIPAS----VLDIGCGTGyltrALLKRFPQA-EFIALDISAGMLAQAKTKLSENVQ-----FICG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  108 ageDMHQ--VTDGSVDVVVCTLVLCSVKNQEKILREVCRVLKPGGAFYFMEHVADERSTWNYFWQQVLDPVwflffdgcn 185
Cdd:TIGR02072  88 ---DAEKlpLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSFGQHGLRY--------- 155

                         170
                  ....*....|....*....
gi 568993318  186 LTRESWKTIEQASFSKLKL 204
Cdd:TIGR02072 156 LSLDELKALLKNSFELLTL 174
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
49-156 9.67e-07

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 47.82  E-value: 9.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318   49 GPSGKLTLLEVGCGTGA-NFKFYP---PGCRVTCIDPNPNFEKFLFKSVAENRQLQFErFVVAAGEDMhQVTDGSVDVVV 124
Cdd:pfam01209  39 GVKRGNKFLDVAGGTGDwTFGLSDsagSSGKVVGLDINENMLKEGEKKAKEEGKYNIE-FLQGNAEEL-PFEDDSFDIVT 116

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568993318  125 CTLVLCSVKNQEKILREVCRVLKPGGAFYFME 156
Cdd:pfam01209 117 ISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLE 148
arsM PRK11873
arsenite methyltransferase;
115-153 1.02e-06

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 48.02  E-value: 1.02e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 568993318 115 VTDGSVDVVVCTLVLCSVKNQEKILREVCRVLKPGGAFY 153
Cdd:PRK11873 142 VADNSVDVIISNCVINLSPDKERVFKEAFRVLKPGGRFA 180
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 31-172 1.31e-06

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 47.83  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  31 EQMASQKRELFSNLQEFAGPSGKLTLLEVGCGTGANFKFY-PPGCRVTCIDPNPNFekflfksVAENRQLQFERFVVAAG 109
Cdd:PRK10258  21 EQHAELQRQSADALLAMLPQRKFTHVLDAGCGPGWMSRYWrERGSQVTALDLSPPM-------LAQARQKDAADHYLAGD 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568993318 110 EDMHQVTDGSVDVVVCTLVLCSVKNQEKILREVCRVLKPGGAFYFMEHVADERSTWNYFWQQV 172
Cdd:PRK10258  94 IESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAV 156
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
51-207 5.06e-06

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 45.24  E-value: 5.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  51 SGKLTLLEVGCGTganfkFYPPGCRVTCIDPNPNfekflfksvaenrqlqferfVVAAGE--DMHQVTDGSVDVVVCTLV 128
Cdd:COG4627    1 SLSPLKLNIGCGP-----KRLPGWLNVDIVPAPG--------------------VDIVGDltDPLPFPDNSVDAIYSSHV 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318 129 L--CSVKNQEKILREVCRVLKPGG---------AFYFMEHVADERSTWNYFWQQVLDPVWFLFF-DGCNLTRESWKTIEQ 196
Cdd:COG4627   56 LehLDYEEAPLALKECYRVLKPGGilrivvpdlEHVARLYLAEYDAALDVAELRLAGPIDPLGIiLGERLAGLAARHSVL 135

                        170
                 ....*....|.
gi 568993318 197 ASFSKLKLQHI 207
Cdd:COG4627  136 FRTGFTRLALT 146
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 48-150 4.90e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 42.83  E-value: 4.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  48 AGPSGKLTLLEVGCGTG--ANF--KFYPPGCRVTCIDPNPNF-----EKFLfksvAENRQLQFErFVVAAGEDMhQVTDG 118
Cdd:PRK00216  47 LGVRPGDKVLDLACGTGdlAIAlaKAVGKTGEVVGLDFSEGMlavgrEKLR----DLGLSGNVE-FVQGDAEAL-PFPDN 120

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568993318 119 SVDVVVCTLVLCSVKNQEKILREVCRVLKPGG 150
Cdd:PRK00216 121 SFDAVTIAFGLRNVPDIDKALREMYRVLKPGG 152
PRK06202 PRK06202
hypothetical protein; Provisional
 50-218 8.34e-05

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 42.29  E-value: 8.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  50 PSGKLTLLEVGCGTG------------ANFKFyppgcRVTCIDPNPnfEKFLF-KSVAENRQLQFERFVVAAgedmhQVT 116
Cdd:PRK06202  58 ADRPLTLLDIGCGGGdlaidlarwarrDGLRL-----EVTAIDPDP--RAVAFaRANPRRPGVTFRQAVSDE-----LVA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318 117 DGS-VDVVVCTLVLCSVKNQE-KILREVCRVLKPGGAFyfmehVAD-ERSTWNY--FW--QQVLDPVWFLFFDGCNLTRE 189
Cdd:PRK06202 126 EGErFDVVTSNHFLHHLDDAEvVRLLADSAALARRLVL-----HNDlIRSRLAYalFWagTRLLSRSSFVHTDGLLSVRR 200

                        170       180
                 ....*....|....*....|....*....
gi 568993318 190 SWKTIEQASFsklklqhiqAPLSWTLVRP 218
Cdd:PRK06202 201 SYTPAELAAL---------APQGWRVERQ 220
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 38-129 1.98e-04

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 41.48  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  38 RELFSNLQEfAGPSGK-LTLLEVGCGTG----ANFKFYPPGCRVTCIDPNP---NFEKFLFKSVAEN--RQLQFERFVVA 107
Cdd:COG5459   66 RAALAELAE-AGPDFApLTVLDVGAGPGtaawAAADAWPSLLDATLLERSAaalALGRRLARAAANPalETAEWRLADLA 144

                         90       100
                 ....*....|....*....|..
gi 568993318 108 AGEDmhqvtDGSVDVVVCTLVL 129
Cdd:COG5459  145 AALP-----APPADLVVASYVL 161
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
50-155 5.85e-04

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 39.95  E-value: 5.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  50 PSGKLTLLEVGCGTGA-NFKFYPPGCRVTCIDPNPNFEKFLFKSVAENRQLQFERFVVAAGEDMHQVTDGSVDVVVCTLV 128
Cdd:PRK11036  42 PPRPLRVLDAGGGEGQtAIKLAELGHQVILCDLSAEMIQRAKQAAEAKGVSDNMQFIHCAAQDIAQHLETPVDLILFHAV 121

                         90       100
                 ....*....|....*....|....*..
gi 568993318 129 LCSVKNQEKILREVCRVLKPGGAFYFM 155
Cdd:PRK11036 122 LEWVADPKSVLQTLWSVLRPGGALSLM 148
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 57-175 9.09e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 38.63  E-value: 9.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  57 LEVGCGTGanfkfY---------PPGCRVTCIDPNP--------NFEKFLFKSVAenrqlqfeRFVVA-AGEDMHQVTDG 118
Cdd:COG4122   21 LEIGTGTG-----YstlwlaralPDDGRLTTIEIDPeraaiareNFARAGLADRI--------RLILGdALEVLPRLADG 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318 119 SVDvvvctLVLC-SVKNQ-EKILREVCRVLKPGGAFyfmehVADerstwNYFWQ-QVLDP 175
Cdd:COG4122   88 PFD-----LVFIdADKSNyPDYLELALPLLRPGGLI-----VAD-----NVLWHgRVADP 132
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 55-154 1.38e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 38.25  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993318  55 TLLEVGCGTG---ANFKFYPPGCRVTCIDPNpnfekflFKSVA---EN-RQLQFERFVVAAGEDMHQVTDGSVDVVVC-- 125
Cdd:COG2813   52 RVLDLGCGYGvigLALAKRNPEARVTLVDVN-------ARAVElarANaAANGLENVEVLWSDGLSGVPDGSFDLILSnp 124

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568993318 126 ----------TLVlcsvknqEKILREVCRVLKPGGAFYF 154
Cdd:COG2813  125 pfhagravdkEVA-------HALIADAARHLRPGGELWL 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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