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Conserved domains on  [gi|568995953|ref|XP_006522493|]
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solute carrier family 15 member 2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1704 super family cl36771
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
 2-403 8.47e-173

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00926:

Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 498.90  E-value: 8.47e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953    2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVNF 81
Cdd:TIGR00926 236 STKRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMDGDVGGFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTRF 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   82 SSLRKMAVGMILACLAFAVAALVEIKINGMIHPQPASQEIFLQVLNLADGEIEVTVQGNRNNPLLVESISSFQNTTHYSK 161
Cdd:TIGR00926 316 TSLRKMAVGGLLAALSFFVAALVQLKVNPTLPEEPSANEIFLQVLNTDCTICDFSVLSKRVLPHDVYLHLDKKNTSGDQG 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  162 LRLETKSQDL-----------HFHLKYNNLSVHNEYSVEEKNCYQLVVHENGESLSSMLVKDTGIKPANGMTAIRFINTL 230
Cdd:TIGR00926 396 LFTTKSSAKGwtltydlsydgACGLTGNCPKTTDAHELEPKISYVLLLSQGGYQLTANTDKPTDAKTEKGMGSVRLVNTL 475

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  231 HKDM-NISLDANAPLSVGKDYGVSEYRTVQRG-KYPAVHCETEDNVFSLNLG--QLDFGTTYLFVIT-NITNRGLQAWKA 305
Cdd:TIGR00926 476 NGEFgMISLCTSDSDSVTPCNPRDPYDFYFRGtKYPANTCDRIDNAKSSTFLsnQLDMGIYYLIVITeNSKIDELQAQIV 555

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  306 EDIPANKLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQFSGL-VQWAEFVL 384
Cdd:TIGR00926 556 ELVSVNTVSILWQIPQYVILTAGEVLFSVTGLEFSYSQAPPNMKSVLQALWLLTVAIGNLIVVVIAEFENFsVQAAEFFL 635

                         410
                  ....*....|....*....
gi 568995953  385 FSCLLLVVCLIFSVMGYYY 403
Cdd:TIGR00926 636 FASLMLVVMAIFSILAYFY 654
 
Name Accession Description Interval E-value
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
 2-403 8.47e-173

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 498.90  E-value: 8.47e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953    2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVNF 81
Cdd:TIGR00926 236 STKRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMDGDVGGFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTRF 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   82 SSLRKMAVGMILACLAFAVAALVEIKINGMIHPQPASQEIFLQVLNLADGEIEVTVQGNRNNPLLVESISSFQNTTHYSK 161
Cdd:TIGR00926 316 TSLRKMAVGGLLAALSFFVAALVQLKVNPTLPEEPSANEIFLQVLNTDCTICDFSVLSKRVLPHDVYLHLDKKNTSGDQG 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  162 LRLETKSQDL-----------HFHLKYNNLSVHNEYSVEEKNCYQLVVHENGESLSSMLVKDTGIKPANGMTAIRFINTL 230
Cdd:TIGR00926 396 LFTTKSSAKGwtltydlsydgACGLTGNCPKTTDAHELEPKISYVLLLSQGGYQLTANTDKPTDAKTEKGMGSVRLVNTL 475

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  231 HKDM-NISLDANAPLSVGKDYGVSEYRTVQRG-KYPAVHCETEDNVFSLNLG--QLDFGTTYLFVIT-NITNRGLQAWKA 305
Cdd:TIGR00926 476 NGEFgMISLCTSDSDSVTPCNPRDPYDFYFRGtKYPANTCDRIDNAKSSTFLsnQLDMGIYYLIVITeNSKIDELQAQIV 555

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  306 EDIPANKLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQFSGL-VQWAEFVL 384
Cdd:TIGR00926 556 ELVSVNTVSILWQIPQYVILTAGEVLFSVTGLEFSYSQAPPNMKSVLQALWLLTVAIGNLIVVVIAEFENFsVQAAEFFL 635

                         410
                  ....*....|....*....
gi 568995953  385 FSCLLLVVCLIFSVMGYYY 403
Cdd:TIGR00926 636 FASLMLVVMAIFSILAYFY 654
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
 2-405 1.50e-88

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 275.65  E-value: 1.50e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVNF 81
Cdd:cd17347  200 DVKALLRVLVLFIPLPVFWALFDQQGSRWTLQAEQMDGLVGGFTILPDQMQALNPILILILIPLFDYVIYPLLERCGIPL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  82 SSLRKMAVGMILACLAFAVAALVEIKINGMIHPQPASQEIflqvlnladgeievtvqgnrnnpllvesissfqntthysk 161
Cdd:cd17347  280 TPLRKMGVGMILAALAFVIAGFLQLRIDGGLPGQPDPGEV---------------------------------------- 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953 162 lrletksqdlhfhlkynnlsvhneysveekncyqlvvhengeslssmlvkdtgikpangmtairfintlhkdmnisldan 241
Cdd:cd17347      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953 242 aplsvgkdygvseyrtvqrgkypavhcetednvfslnlgqldfgttylfvitnitnrglqaWKAEDIPANKLSIAWQLPQ 321
Cdd:cd17347  320 -------------------------------------------------------------TTFEDIEPNSVSILWQLPQ 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953 322 YVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQFS-GLVQWAEFVLFSCLLLVVCLIFSVMG 400
Cdd:cd17347  339 YVVLTAGEVLFSITGLEFAYTQAPKSMKSVVQAAWLLTVALGNLIVVIVAELIqFSSQAAEYFFFAGLMLVVAVVFALLA 418


                 ....*
gi 568995953 401 YYYVP 405
Cdd:cd17347  419 RFYKY 423
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
 1-150 2.08e-50

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 175.20  E-value: 2.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953    1 MDVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVN 80
Cdd:pfam00854 196 EEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQARTMNRKIGSFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCTGG 275

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   81 FSSLRKMAVGMILACLAFAVAALVEIKINGMIHPQPASQEIFLQVLNLADGEIEVTVQGNRNNPLLVESI 150
Cdd:pfam00854 276 LTPLQKMAVGLFLASLAFAIAAIVQLKRNDTGPEFPIAQEVPISVLWLIPQYLLIGFGELFISIGGLEFF 345
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
4-103 2.28e-17

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 84.10  E-value: 2.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   4 KALTRILFLYIPLPMFWALLDQQGSRWTLQA-NKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLiSKCGVNFS 82
Cdd:COG3104  270 KRLLAILILFLFSIVFWALYEQAGTSLNLFAdRNVDRSLFGFEIPPSWFQSLNPLFIIILAPVFAALWTKL-GKRGKEPS 348

                         90       100
                 ....*....|....*....|.
gi 568995953  83 SLRKMAVGMILACLAFAVAAL 103
Cdd:COG3104  349 TPTKFALGLLLLGLGFLVMAL 369
tppB PRK09584
dipeptide/tripeptide permease DtpA;
41-100 2.12e-03

dipeptide/tripeptide permease DtpA;


Pssm-ID: 181969  Cd Length: 500  Bit Score: 40.13  E-value: 2.12e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  41 LGFFVlQPDQMQVLNPFLVLVFIPLFdLVIYrliSKCGVNFSSLRKMAVGMILACLAFAV 100
Cdd:PRK09584 312 LGIAV-EPEQYQALNPFWIMIGSPIL-AAIY---NKMGDRLPMPHKFAIGMVLCSGAFLV 366
 
Name Accession Description Interval E-value
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
 2-403 8.47e-173

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 498.90  E-value: 8.47e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953    2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVNF 81
Cdd:TIGR00926 236 STKRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMDGDVGGFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTRF 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   82 SSLRKMAVGMILACLAFAVAALVEIKINGMIHPQPASQEIFLQVLNLADGEIEVTVQGNRNNPLLVESISSFQNTTHYSK 161
Cdd:TIGR00926 316 TSLRKMAVGGLLAALSFFVAALVQLKVNPTLPEEPSANEIFLQVLNTDCTICDFSVLSKRVLPHDVYLHLDKKNTSGDQG 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  162 LRLETKSQDL-----------HFHLKYNNLSVHNEYSVEEKNCYQLVVHENGESLSSMLVKDTGIKPANGMTAIRFINTL 230
Cdd:TIGR00926 396 LFTTKSSAKGwtltydlsydgACGLTGNCPKTTDAHELEPKISYVLLLSQGGYQLTANTDKPTDAKTEKGMGSVRLVNTL 475

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  231 HKDM-NISLDANAPLSVGKDYGVSEYRTVQRG-KYPAVHCETEDNVFSLNLG--QLDFGTTYLFVIT-NITNRGLQAWKA 305
Cdd:TIGR00926 476 NGEFgMISLCTSDSDSVTPCNPRDPYDFYFRGtKYPANTCDRIDNAKSSTFLsnQLDMGIYYLIVITeNSKIDELQAQIV 555

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  306 EDIPANKLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQFSGL-VQWAEFVL 384
Cdd:TIGR00926 556 ELVSVNTVSILWQIPQYVILTAGEVLFSVTGLEFSYSQAPPNMKSVLQALWLLTVAIGNLIVVVIAEFENFsVQAAEFFL 635

                         410
                  ....*....|....*....
gi 568995953  385 FSCLLLVVCLIFSVMGYYY 403
Cdd:TIGR00926 636 FASLMLVVMAIFSILAYFY 654
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
 2-405 1.50e-88

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 275.65  E-value: 1.50e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVNF 81
Cdd:cd17347  200 DVKALLRVLVLFIPLPVFWALFDQQGSRWTLQAEQMDGLVGGFTILPDQMQALNPILILILIPLFDYVIYPLLERCGIPL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  82 SSLRKMAVGMILACLAFAVAALVEIKINGMIHPQPASQEIflqvlnladgeievtvqgnrnnpllvesissfqntthysk 161
Cdd:cd17347  280 TPLRKMGVGMILAALAFVIAGFLQLRIDGGLPGQPDPGEV---------------------------------------- 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953 162 lrletksqdlhfhlkynnlsvhneysveekncyqlvvhengeslssmlvkdtgikpangmtairfintlhkdmnisldan 241
Cdd:cd17347      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953 242 aplsvgkdygvseyrtvqrgkypavhcetednvfslnlgqldfgttylfvitnitnrglqaWKAEDIPANKLSIAWQLPQ 321
Cdd:cd17347  320 -------------------------------------------------------------TTFEDIEPNSVSILWQLPQ 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953 322 YVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQFS-GLVQWAEFVLFSCLLLVVCLIFSVMG 400
Cdd:cd17347  339 YVVLTAGEVLFSITGLEFAYTQAPKSMKSVVQAAWLLTVALGNLIVVIVAELIqFSSQAAEYFFFAGLMLVVAVVFALLA 418


                 ....*
gi 568995953 401 YYYVP 405
Cdd:cd17347  419 RFYKY 423
MFS_SLC15A2 cd17411
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ...
 2-108 5.71e-55

Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340969 [Multi-domain]  Cd Length: 403  Bit Score: 187.72  E-value: 5.71e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVNF 81
Cdd:cd17411  202 EVKMVTRVLFLYIPLPMFWALFDQQGSRWTLQATRMNDFGGGFVLQPDQMQTLNPLLILVFIPIFDLGIYPLVSKCKINF 281

                         90       100
                 ....*....|....*....|....*..
gi 568995953  82 SSLRKMAVGMILACLAFAVAALVEIKI 108
Cdd:cd17411  282 TSLRKMATGMILAALAFAVAAAVEIKI 308
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
 1-150 2.08e-50

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 175.20  E-value: 2.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953    1 MDVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVN 80
Cdd:pfam00854 196 EEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQARTMNRKIGSFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCTGG 275

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   81 FSSLRKMAVGMILACLAFAVAALVEIKINGMIHPQPASQEIFLQVLNLADGEIEVTVQGNRNNPLLVESI 150
Cdd:pfam00854 276 LTPLQKMAVGLFLASLAFAIAAIVQLKRNDTGPEFPIAQEVPISVLWLIPQYLLIGFGELFISIGGLEFF 345
MFS_SLC15A2 cd17411
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ...
 315-409 2.90e-50

Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340969 [Multi-domain]  Cd Length: 403  Bit Score: 175.01  E-value: 2.90e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953 315 IAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQFSGLVQWAEFVLFSCLLLVVCL 394
Cdd:cd17411  308 IAWQLPQYVLLSAGEVMFSITGLEFSYSQAPASMKSVLQAGWLLTVAFGNVIVLIVAQAAGMAQWAEFLLFAALLLAVCI 387

                         90
                 ....*....|....*
gi 568995953 395 IFSVMGYYYVPLKSE 409
Cdd:cd17411  388 IFSIMGYFYVYVDPE 402
MFS_SLC15A1 cd17412
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ...
 3-115 2.78e-47

Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340970 [Multi-domain]  Cd Length: 415  Bit Score: 167.71  E-value: 2.78e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   3 VKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVNFS 82
Cdd:cd17412  214 IKMVLKVLFLYIPLPMFWALFDQQGSRWTLQATTMDGNFGAIQIQPDQMQTVNPILIIIMVPIFDAVIYPLIKKCKINFT 293

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568995953  83 SLRKMAVGMILACLAFAVAALVEIKINGMIhPQ 115
Cdd:cd17412  294 PLRKMTVGMFLAALAFVAAALLQIQMAWQI-PQ 325
MFS_SLC15A1 cd17412
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ...
 312-404 1.49e-39

Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340970 [Multi-domain]  Cd Length: 415  Bit Score: 146.91  E-value: 1.49e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953 312 KLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQFSGLV-QWAEFVLFSCLLL 390
Cdd:cd17412  316 QIQMAWQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAEAGSISeQWAEYVLFAALLV 395

                         90
                 ....*....|....
gi 568995953 391 VVCLIFSVMGYYYV 404
Cdd:cd17412  396 AVCIIFAIMAYFYT 409
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
 2-126 2.10e-21

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 95.58  E-value: 2.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVNF 81
Cdd:cd06175  197 EVKQLLRALPLFAFCILFWTVYAQMTTSYVLQALTLVRSTGLFTIPPASMQAFNPILLLLLIPVLDKVVYPLIRRYGVGL 276

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568995953  82 SSLRKMAVGMILACLAFAVAALVEIKINGMIHPQ-----PASQEIFLQVL 126
Cdd:cd06175  277 SPLTKIGLGFFFGSLSMFVAGFLELKRLNTAHAHgpvvtTSPLSFWWQIP 326
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
4-103 2.28e-17

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 84.10  E-value: 2.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   4 KALTRILFLYIPLPMFWALLDQQGSRWTLQA-NKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLiSKCGVNFS 82
Cdd:COG3104  270 KRLLAILILFLFSIVFWALYEQAGTSLNLFAdRNVDRSLFGFEIPPSWFQSLNPLFIIILAPVFAALWTKL-GKRGKEPS 348

                         90       100
                 ....*....|....*....|.
gi 568995953  83 SLRKMAVGMILACLAFAVAAL 103
Cdd:COG3104  349 TPTKFALGLLLLGLGFLVMAL 369
MFS_NPF8 cd17418
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ...
 305-374 2.28e-13

NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340976 [Multi-domain]  Cd Length: 447  Bit Score: 71.35  E-value: 2.28e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568995953 305 AEDIPANKLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGN----IIVLIVAQFS 374
Cdd:cd17418  330 VESGPPVPMSIFWQIPQYFLIGAAEVFTFIGQLEFFYDQSPDAMRSLCSALSLLTTALGNylssLIVTLVTYVT 403
MFS_PTR2 cd17350
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ...
 311-368 1.71e-11

Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340908 [Multi-domain]  Cd Length: 438  Bit Score: 65.57  E-value: 1.71e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568995953 311 NKLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVL 368
Cdd:cd17350  346 NDIHVWIQIPAYVLIAFSEIFASITGLEYAYTKAPPSMKSFITALFLLTNAFGAALSI 403
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
 313-375 1.73e-11

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 65.86  E-value: 1.73e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568995953 313 LSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGN----IIVLIVAQFSG 375
Cdd:cd17419  340 LSIFWQIPQYVLVGASEVFTYVGQLEFFYDQAPDGLRSLGSALCMASVALGNylssLLVTIVNKVTT 406
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 9-103 7.65e-11

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 63.36  E-value: 7.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   9 ILFLYipLPMFWALLDQQGSRWTLQANK-MDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLvIYRLISKCGVNFSSLRKM 87
Cdd:cd17346  198 ILFLF--AVVFWAIYEQAGTSLALFADEnVDRLLGGFTIPPSWFQSLNPLFIILLAPILAA-LWTKLGKRGKDPSIPTKF 274

                         90
                 ....*....|....*.
gi 568995953  88 AVGMILACLAFAVAAL 103
Cdd:cd17346  275 ALGLLLLGLSFLLMVL 290
MFS_NPF cd17351
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ...
 2-107 1.03e-10

Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340909 [Multi-domain]  Cd Length: 445  Bit Score: 63.41  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGF-FVLQPDQMQVLNPFLVLVFIPLFDLVIYRL---ISKC 77
Cdd:cd17351  209 EVKCLLRLLPIWATTILLSTVYAQMQTFFVQQGLTMDRRLGGsFEIPAASLSVFSTLFVLLFIPLYDRVFVPFarrYTGN 288

                         90       100       110
                 ....*....|....*....|....*....|
gi 568995953  78 GVNFSSLRKMAVGMILACLAFAVAALVEIK 107
Cdd:cd17351  289 PRGITPLQRIGIGLVLSILAMAVAALVEVK 318
MFS_NPF cd17351
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ...
 313-375 1.41e-10

Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340909 [Multi-domain]  Cd Length: 445  Bit Score: 63.02  E-value: 1.41e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568995953 313 LSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGN----IIVLIVAQFSG 375
Cdd:cd17351  338 MSVFWLLPQYFLLGLAEVFTYIGQLEFFYDEAPDGMRSLGTALFLLTIALGNflssALVTIVNKITG 404
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
 2-107 3.47e-10

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 61.51  E-value: 3.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLG-FFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISK---C 77
Cdd:cd17416  212 DLKSLIRVIPIWSTGIILSLAMAQQMSLTVLQALVMDRHLGpSFQIPAGSITVFLLITLTIFIPLYDRVLVPLLRKitgR 291

                         90       100       110
                 ....*....|....*....|....*....|
gi 568995953  78 GVNFSSLRKMAVGMILACLAFAVAALVEIK 107
Cdd:cd17416  292 GRGLTLLQRVGIGIVFSILSMAVAAIVERK 321
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
 2-107 4.48e-10

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 61.13  E-value: 4.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLG-FFVLQPDQMQVLNPFLVLVFIPLFDLV---IYRLISKC 77
Cdd:cd17417  214 EVKLVLRLIPIWFTTLVFTVVFAQSPTFFTKQGVTMDRTIGpNFKIPPASLQSFITLSILISIPIYDRVfvpIARKITGN 293

                         90       100       110
                 ....*....|....*....|....*....|
gi 568995953  78 GVNFSSLRKMAVGMILACLAFAVAALVEIK 107
Cdd:cd17417  294 PRGITLLQRIGIGMFLSILAMVIAALVEMK 323
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
 2-125 1.42e-09

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 59.70  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVN- 80
Cdd:cd17419  213 EVKCILRLLPIWLSTIIYSVVYTQMATLFVEQGAAMDTSFGNFKIPPASMSVFEILSVAVGTVLYRKFLVPLLRKVTGHp 292

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568995953  81 --FSSLRKMAVGMILACLAFAVAALVEIKINGMIHP-------QPASQEIFLQV 125
Cdd:cd17419  293 kgITELQRMGIGLVIGILAMVVAALVEIQRLKVARPsnlddptSPSPLSIFWQI 346
MFS_NPF6 cd17413
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ...
 2-107 2.79e-09

NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340971 [Multi-domain]  Cd Length: 457  Bit Score: 59.00  E-value: 2.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVN- 80
Cdd:cd17413  225 EVKMVVRMLPIWATTILFWTVYAQMTTFSVEQAETMDRNIGSFEIPPASMAVFLVATILLTTAVYDRVIVPLCRKLTGHp 304

                         90       100
                 ....*....|....*....|....*....
gi 568995953  81 --FSSLRKMAVGMILACLAFAVAALVEIK 107
Cdd:cd17413  305 qgLTTLQRIGVGLVFSCLAMAVAALVELK 333
MFS_SLC15A3_4 cd17348
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ...
 310-366 5.02e-09

Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340906 [Multi-domain]  Cd Length: 435  Bit Score: 57.88  E-value: 5.02e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568995953 310 ANKLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNII 366
Cdd:cd17348  325 AADLPIWWQIPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFV 381
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
 312-366 5.83e-08

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 54.58  E-value: 5.83e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568995953 312 KLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNII 366
Cdd:cd17417  341 PMSIFWLLPQYILLGIADVFTMVGMQEFFYDQVPDEMRSLGTALYLSVFGVGSFL 395
MFS_NPF3 cd17415
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ...
 313-375 4.15e-07

NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340973 [Multi-domain]  Cd Length: 448  Bit Score: 52.07  E-value: 4.15e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568995953 313 LSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGN----IIVLIVAQFSG 375
Cdd:cd17415  342 ISVFWLVPQYILHGIAEAFMSIGHLEFFYDQSPESMRSTATALFWSTISLGSylstLLVTLVHKETS 408
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 309-400 2.71e-06

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 49.11  E-value: 2.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953 309 PANKLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQFSGLVQWAEFVLFSCL 388
Cdd:cd17346  297 GSGKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGFYAQPKDPLASALVYT 376

                         90
                 ....*....|....
gi 568995953 389 LL--VVCLIFSVMG 400
Cdd:cd17346  377 DYfgLIGVIALVAG 390
MFS_NPF4 cd17414
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ...
 2-107 4.62e-06

NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340972 [Multi-domain]  Cd Length: 456  Bit Score: 48.56  E-value: 4.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   2 DVKALTRILFLYIPLPMFWALLDQQGSRWTLQANKMDGDL-GFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVN 80
Cdd:cd17414  220 EVKIVLKMLPIFACTIILNCILAQLQTFSVQQGSTMNRTKiGSFNIPPASLQAIPVIFMLILVPLYDHLLVPFARKITGH 299

                         90       100       110
                 ....*....|....*....|....*....|
gi 568995953  81 FSS---LRKMAVGMILACLAFAVAALVEIK 107
Cdd:cd17414  300 ESGithLQRIGIGLVLSTLSMVVAALVETK 329
MFS_NPF3 cd17415
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ...
 25-107 7.79e-06

NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340973 [Multi-domain]  Cd Length: 448  Bit Score: 47.83  E-value: 7.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  25 QQGSRWTLQANKMDGDLGF-FVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKC-----GVNFssLRKMAVGMILACLAF 98
Cdd:cd17415  236 QQHTFSIQQARTMNRHLTPsFQIPPASMSVFGILSLLTTVPLYDRVLMPVARKFtgnerGITF--LQRMGIGLFISILAT 313


                 ....*....
gi 568995953  99 AVAALVEIK 107
Cdd:cd17415  314 VVAAFVEVK 322
MFS_NPF6 cd17413
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ...
 282-375 1.84e-05

NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340971 [Multi-domain]  Cd Length: 457  Bit Score: 46.68  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953 282 LDFGTTYLFVITNITNRGLQAWKAEDIPAN--KLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLT 359
Cdd:cd17413  317 LVFSCLAMAVAALVELKRLRIAHAHGKPVKtvPMSVFWLVPQYFLVGAGEAFIYTGQLDFFIRESPKGMKSMSTGLFLST 396

                         90       100
                 ....*....|....*....|
gi 568995953 360 VAVG----NIIVLIVAQFSG 375
Cdd:cd17413  397 LSLGffvsSFLVSIVNRVTG 416
MFS_SLC15A3_4 cd17348
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ...
 1-130 3.01e-05

Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340906 [Multi-domain]  Cd Length: 435  Bit Score: 45.94  E-value: 3.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953   1 MDVKALTRILFLYIPLPMFWALLDQQGSRWTLQA-----------NKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLV 69
Cdd:cd17348  186 IDVKALVKILPVFLALIPYWTVYFQMQTTYVLQSlhlkipnifisNIAGITNSSHTFPAAWLTMFDAVLILILIPLKDKL 265

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568995953  70 IYRLISKCGVNFSSLRKMAVGMILA-CLAFAVAALVEIKINGMIHPQPASQEIFLQVLNLAD 130
Cdd:cd17348  266 VDPFLKRRGLLPSSLKRIAVGMFFVmCSAIAAGILESKRLEIVKHNTTIQQQIGNVTYYAAD 327
yjdL_sub1_fam TIGR00924
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ...
 8-102 5.36e-05

amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273342 [Multi-domain]  Cd Length: 475  Bit Score: 45.21  E-value: 5.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953    8 RILFLYIPL----PMFWALLDQQGSRWTLQA-NKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKcGVNFS 82
Cdd:TIGR00924 269 NKMYAYIVLfleaVVFWVLYAQMPTSLNFFAdNNMHHEMLGMSVPVIWFQSLNPFWVVVGSPVLAMIWTRLGRK-GKDPT 347

                          90       100
                  ....*....|....*....|
gi 568995953   83 SLRKMAVGMILACLAFAVAA 102
Cdd:TIGR00924 348 TPLKFTLGMLFCGASFLTFA 367
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
 312-366 3.35e-04

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 42.64  E-value: 3.35e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568995953 312 KLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNII 366
Cdd:cd17416  335 PMSVLWLVPQLVLMGIAEAFHFIGQIEFFYQEFPESMRSTATSLFSLGMGVASYL 389
MFS_NPF4 cd17414
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ...
 312-370 7.18e-04

NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340972 [Multi-domain]  Cd Length: 456  Bit Score: 41.63  E-value: 7.18e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568995953 312 KLSIAWQLPQYVLVTAAEvMFSVTGL-EFSYSQAPSSMKSVLQAAWLLTVAVG----NIIVLIV 370
Cdd:cd17414  347 PISIFWIALQFLILGISD-MFTAVGLlEFFYTESPSSMRSLGTALTWCSYSFGfylsSVLVSVV 409
tppB PRK09584
dipeptide/tripeptide permease DtpA;
41-100 2.12e-03

dipeptide/tripeptide permease DtpA;


Pssm-ID: 181969  Cd Length: 500  Bit Score: 40.13  E-value: 2.12e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995953  41 LGFFVlQPDQMQVLNPFLVLVFIPLFdLVIYrliSKCGVNFSSLRKMAVGMILACLAFAV 100
Cdd:PRK09584 312 LGIAV-EPEQYQALNPFWIMIGSPIL-AAIY---NKMGDRLPMPHKFAIGMVLCSGAFLV 366
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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