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Conserved domains on  [gi|568999125|ref|XP_006523772|]
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hepatoma-derived growth factor-related protein 2 isoform X4 [Mus musculus]

Protein Classification

LEDGF domain-containing protein( domain architecture ID 10568669)

LEDGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LEDGF pfam11467
Lens epithelium-derived growth factor (LEDGF); LEDGF is a chromatin-associated protein that ...
 343-440 4.66e-31

Lens epithelium-derived growth factor (LEDGF); LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure.


:

Pssm-ID: 463284 [Multi-domain]  Cd Length: 120  Bit Score: 116.66  E-value: 4.66e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999125  343 EERLQKLHSEIKFALKVDNPDVRKCLSALEELGTLQVTSQILQKNTDVVATLKKIRRYKAN------------------K 404
Cdd:pfam11467   1 ERKLQELDLDIKSCLKLDNADVDKCLEALDELKSLQVTPLMLKKNPECVETIKKLRRYVGNleewkmdeeeeaefkekaQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568999125  405 DVMAKAAEVYTRLKSRVLGPKVEALQKVNKAGAEKE 440
Cdd:pfam11467  81 LIRDKATEIYNKFKSLFLVPEGEVNFWPDFNEEVKE 116
 
Name Accession Description Interval E-value
LEDGF pfam11467
Lens epithelium-derived growth factor (LEDGF); LEDGF is a chromatin-associated protein that ...
 343-440 4.66e-31

Lens epithelium-derived growth factor (LEDGF); LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure.


Pssm-ID: 463284 [Multi-domain]  Cd Length: 120  Bit Score: 116.66  E-value: 4.66e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999125  343 EERLQKLHSEIKFALKVDNPDVRKCLSALEELGTLQVTSQILQKNTDVVATLKKIRRYKAN------------------K 404
Cdd:pfam11467   1 ERKLQELDLDIKSCLKLDNADVDKCLEALDELKSLQVTPLMLKKNPECVETIKKLRRYVGNleewkmdeeeeaefkekaQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568999125  405 DVMAKAAEVYTRLKSRVLGPKVEALQKVNKAGAEKE 440
Cdd:pfam11467  81 LIRDKATEIYNKFKSLFLVPEGEVNFWPDFNEEVKE 116
 
Name Accession Description Interval E-value
LEDGF pfam11467
Lens epithelium-derived growth factor (LEDGF); LEDGF is a chromatin-associated protein that ...
 343-440 4.66e-31

Lens epithelium-derived growth factor (LEDGF); LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure.


Pssm-ID: 463284 [Multi-domain]  Cd Length: 120  Bit Score: 116.66  E-value: 4.66e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999125  343 EERLQKLHSEIKFALKVDNPDVRKCLSALEELGTLQVTSQILQKNTDVVATLKKIRRYKAN------------------K 404
Cdd:pfam11467   1 ERKLQELDLDIKSCLKLDNADVDKCLEALDELKSLQVTPLMLKKNPECVETIKKLRRYVGNleewkmdeeeeaefkekaQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568999125  405 DVMAKAAEVYTRLKSRVLGPKVEALQKVNKAGAEKE 440
Cdd:pfam11467  81 LIRDKATEIYNKFKSLFLVPEGEVNFWPDFNEEVKE 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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