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Conserved domains on  [gi|569000749|ref|XP_006524559|]
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regulator of microtubule dynamics protein 2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15331 super family cl30292
type III secretion system translocator chaperone SicA;
647-716 4.00e-03

type III secretion system translocator chaperone SicA;


The actual alignment was detected with superfamily member TIGR02552:

Pssm-ID: 357168 [Multi-domain]  Cd Length: 135  Bit Score: 38.04  E-value: 4.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000749  647 EALHNFLKTEELQPGySMSNYMYTAKCYVELGEPQEACKfcnlALLLPVVTKEDKDAHKEVKKMISSLKR 716
Cdd:TIGR02552  69 EAIDAYALAAALDPD-DPRPYFHAAECLLALGEPESALK----ALDLAIEICGENPEYSELKERAEAMLE 133
 
Name Accession Description Interval E-value
LcrH_SycD TIGR02552
type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in ...
 647-716 4.00e-03

type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in type III secretion operons. LcrH, from Yersinia is believed to have a regulatory function in the low-calcium response of the secretion system. The same protein is also known as SycD (SYC = Specific Yop Chaperone) for its chaperone role. In Pseudomonas, where the homolog is known as PcrH, the chaperone role has been demonstrated and the regulatory role appears to be absent. ScyD/LcrH contains three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array.


Pssm-ID: 274197 [Multi-domain]  Cd Length: 135  Bit Score: 38.04  E-value: 4.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000749  647 EALHNFLKTEELQPGySMSNYMYTAKCYVELGEPQEACKfcnlALLLPVVTKEDKDAHKEVKKMISSLKR 716
Cdd:TIGR02552  69 EAIDAYALAAALDPD-DPRPYFHAAECLLALGEPESALK----ALDLAIEICGENPEYSELKERAEAMLE 133
 
Name Accession Description Interval E-value
LcrH_SycD TIGR02552
type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in ...
 647-716 4.00e-03

type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in type III secretion operons. LcrH, from Yersinia is believed to have a regulatory function in the low-calcium response of the secretion system. The same protein is also known as SycD (SYC = Specific Yop Chaperone) for its chaperone role. In Pseudomonas, where the homolog is known as PcrH, the chaperone role has been demonstrated and the regulatory role appears to be absent. ScyD/LcrH contains three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array.


Pssm-ID: 274197 [Multi-domain]  Cd Length: 135  Bit Score: 38.04  E-value: 4.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000749  647 EALHNFLKTEELQPGySMSNYMYTAKCYVELGEPQEACKfcnlALLLPVVTKEDKDAHKEVKKMISSLKR 716
Cdd:TIGR02552  69 EAIDAYALAAALDPD-DPRPYFHAAECLLALGEPESALK----ALDLAIEICGENPEYSELKERAEAMLE 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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