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Conserved domains on  [gi|569001171|ref|XP_006524766|]
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protein cramped-like isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF601 super family cl27239
Protein of unknown function, DUF601; This family represents a conserved region found in ...
 125-205 1.92e-03

Protein of unknown function, DUF601; This family represents a conserved region found in several uncharacterized plant proteins.


The actual alignment was detected with superfamily member pfam04642:

Pssm-ID: 282493 [Multi-domain]  Cd Length: 327  Bit Score: 41.80  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001171   125 SGATPATPAGGSRSSSRNIGSSGPEKEEGKKVRRQWESWS----------TEDKNTFFEGLYEHGKDFEAIQNNIALKYK 194
Cdd:pfam04642   38 AGKKNDAPAPDSGKALKAPAGKDPEKRAADKKRKQPDEDAhsparssrprQEEKDASPSQQKEKGKKEDAPQDLVVLSSR 117

                           90
                   ....*....|.
gi 569001171   195 KKGKPASMVKN 205
Cdd:pfam04642  118 ESETRESERKN 128
PHA03309 super family cl29689
transcriptional regulator ICP4; Provisional
 441-619 3.59e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03309:

Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 41.76  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001171  441 PAQILGIQSGQgiaRGQLKCQRSSAEGKGGGRLLPTA-------DASQSSGESSPESAPAEGAAPSLS-SPDAPDR-PHG 511
Cdd:PHA03309 1780 PERVLGRRQSR---RDSVPVRRRSGAANCGGRWMISAgrsssssSSSSSSSSSSPSSRPSRSATPSLSpSPSPPRRaPVD 1856

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001171  512 LQDSGPHLEKTPVTALAVgRDSPIQESGALPCPCGQPPDlEDELSLLDPFPRylksCQDLIIPEQCRRADTRSGrehpPL 591
Cdd:PHA03309 1857 RSRSGRRRERDRPSANPF-RWAPRQRSRADHSPDGTAPG-DAPLNLEDGPGR----GRPIWTPSSATTLPSRSG----PE 1926

                         170       180
                  ....*....|....*....|....*....
gi 569001171  592 GSVASPETltpssgavADSAPPG-LDPQP 619
Cdd:PHA03309 1927 DSVDETET--------EDSAPPArLAPSP 1947
 
Name Accession Description Interval E-value
DUF601 pfam04642
Protein of unknown function, DUF601; This family represents a conserved region found in ...
 125-205 1.92e-03

Protein of unknown function, DUF601; This family represents a conserved region found in several uncharacterized plant proteins.


Pssm-ID: 282493 [Multi-domain]  Cd Length: 327  Bit Score: 41.80  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001171   125 SGATPATPAGGSRSSSRNIGSSGPEKEEGKKVRRQWESWS----------TEDKNTFFEGLYEHGKDFEAIQNNIALKYK 194
Cdd:pfam04642   38 AGKKNDAPAPDSGKALKAPAGKDPEKRAADKKRKQPDEDAhsparssrprQEEKDASPSQQKEKGKKEDAPQDLVVLSSR 117

                           90
                   ....*....|.
gi 569001171   195 KKGKPASMVKN 205
Cdd:pfam04642  118 ESETRESERKN 128
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 441-619 3.59e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 41.76  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001171  441 PAQILGIQSGQgiaRGQLKCQRSSAEGKGGGRLLPTA-------DASQSSGESSPESAPAEGAAPSLS-SPDAPDR-PHG 511
Cdd:PHA03309 1780 PERVLGRRQSR---RDSVPVRRRSGAANCGGRWMISAgrsssssSSSSSSSSSSPSSRPSRSATPSLSpSPSPPRRaPVD 1856

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001171  512 LQDSGPHLEKTPVTALAVgRDSPIQESGALPCPCGQPPDlEDELSLLDPFPRylksCQDLIIPEQCRRADTRSGrehpPL 591
Cdd:PHA03309 1857 RSRSGRRRERDRPSANPF-RWAPRQRSRADHSPDGTAPG-DAPLNLEDGPGR----GRPIWTPSSATTLPSRSG----PE 1926

                         170       180
                  ....*....|....*....|....*....
gi 569001171  592 GSVASPETltpssgavADSAPPG-LDPQP 619
Cdd:PHA03309 1927 DSVDETET--------EDSAPPArLAPSP 1947
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 162-219 4.09e-03

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 4.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569001171  162 SWSTEDKNTFFEGLYEHGKDFEAIQNNIaLKYKkkgKPASMVknkeqvrHFYYrTWHK 219
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQDF-LPWK---SVGELV-------EFYY-MWKK 46
 
Name Accession Description Interval E-value
DUF601 pfam04642
Protein of unknown function, DUF601; This family represents a conserved region found in ...
 125-205 1.92e-03

Protein of unknown function, DUF601; This family represents a conserved region found in several uncharacterized plant proteins.


Pssm-ID: 282493 [Multi-domain]  Cd Length: 327  Bit Score: 41.80  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001171   125 SGATPATPAGGSRSSSRNIGSSGPEKEEGKKVRRQWESWS----------TEDKNTFFEGLYEHGKDFEAIQNNIALKYK 194
Cdd:pfam04642   38 AGKKNDAPAPDSGKALKAPAGKDPEKRAADKKRKQPDEDAhsparssrprQEEKDASPSQQKEKGKKEDAPQDLVVLSSR 117

                           90
                   ....*....|.
gi 569001171   195 KKGKPASMVKN 205
Cdd:pfam04642  118 ESETRESERKN 128
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 441-619 3.59e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 41.76  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001171  441 PAQILGIQSGQgiaRGQLKCQRSSAEGKGGGRLLPTA-------DASQSSGESSPESAPAEGAAPSLS-SPDAPDR-PHG 511
Cdd:PHA03309 1780 PERVLGRRQSR---RDSVPVRRRSGAANCGGRWMISAgrsssssSSSSSSSSSSPSSRPSRSATPSLSpSPSPPRRaPVD 1856

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001171  512 LQDSGPHLEKTPVTALAVgRDSPIQESGALPCPCGQPPDlEDELSLLDPFPRylksCQDLIIPEQCRRADTRSGrehpPL 591
Cdd:PHA03309 1857 RSRSGRRRERDRPSANPF-RWAPRQRSRADHSPDGTAPG-DAPLNLEDGPGR----GRPIWTPSSATTLPSRSG----PE 1926

                         170       180
                  ....*....|....*....|....*....
gi 569001171  592 GSVASPETltpssgavADSAPPG-LDPQP 619
Cdd:PHA03309 1927 DSVDETET--------EDSAPPArLAPSP 1947
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 162-219 4.09e-03

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 4.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569001171  162 SWSTEDKNTFFEGLYEHGKDFEAIQNNIaLKYKkkgKPASMVknkeqvrHFYYrTWHK 219
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQDF-LPWK---SVGELV-------EFYY-MWKK 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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