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Conserved domains on  [gi|569001632|ref|XP_006524989|]
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WD repeat-containing protein 27 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
513-813 2.09e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 2.09e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLa 592
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL- 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 593 pDAFPKPVTSAQFYyMDTFILLSSGpefcllkyhidlcRDD-IRRYKPKSRyKPIFRLPMTSGAdITSLSAVNDfySHIV 671
Cdd:COG2319  201 -TGHTGAVRSVAFS-PDGKLLASGS-------------ADGtVRLWDLATG-KLLRTLTGHSGS-VRSVAFSPD--GRLL 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 672 LTAGRDRAVEVFDLNAGCSAAVLAEvHSRPVHricqnkgssfvaqhSLAY----NLFLTAAVGDGIRLWDLRNLRCVRCF 747
Cdd:COG2319  262 ASGSADGTVRLWDLATGELLRTLTG-HSGGVN--------------SVAFspdgKLLASGSDDGTVRLWDLATGKLLRTL 326

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569001632 748 EGHPNRSYpcGVAFSPCGRLMACGAEDRHAYVYEMGSSSFLHRLAGHTDTITEVAFNPAAPQLSSG 813
Cdd:COG2319  327 TGHTGAVR--SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-235 2.26e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 2.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632  47 DGSrLCVWSSKDPShQLLTLQGHHQLITAVVFgNQIDPLLLCSASEDYIIMWNVAECRE-KTLKGLTprgtilgsllQTV 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAF-SPDGTFVASSSQDGTIKLWDLRTGKCvATLTGHT----------GEV 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 126 LCLRFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPWQaHTLISVSEDRSFKVWDFCVGSLIYSssi 204
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQT--- 256

                        170       180       190
                 ....*....|....*....|....*....|...
gi 569001632 205 LTAY--PLLNLLINEENQQLVTGSADGQLWIFS 235
Cdd:cd00200  257 LSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
513-813 2.09e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 2.09e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLa 592
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL- 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 593 pDAFPKPVTSAQFYyMDTFILLSSGpefcllkyhidlcRDD-IRRYKPKSRyKPIFRLPMTSGAdITSLSAVNDfySHIV 671
Cdd:COG2319  201 -TGHTGAVRSVAFS-PDGKLLASGS-------------ADGtVRLWDLATG-KLLRTLTGHSGS-VRSVAFSPD--GRLL 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 672 LTAGRDRAVEVFDLNAGCSAAVLAEvHSRPVHricqnkgssfvaqhSLAY----NLFLTAAVGDGIRLWDLRNLRCVRCF 747
Cdd:COG2319  262 ASGSADGTVRLWDLATGELLRTLTG-HSGGVN--------------SVAFspdgKLLASGSDDGTVRLWDLATGKLLRTL 326

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569001632 748 EGHPNRSYpcGVAFSPCGRLMACGAEDRHAYVYEMGSSSFLHRLAGHTDTITEVAFNPAAPQLSSG 813
Cdd:COG2319  327 TGHTGAVR--SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-813 2.76e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.59  E-value: 2.76e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 514 VSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLAp 593
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 594 dAFPKPVTSAQFYYMDTFILLSSGPEFCLLkyhidlcrDDIRRYKPKSRYKPIfrlpmtsGADITSLSAvnDFYSHIVLT 673
Cdd:cd00200   91 -GHTSYVSSVAFSPDGRILSSSSRDKTIKV--------WDVETGKCLTTLRGH-------TDWVNSVAF--SPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 674 AGRDRAVEVFDLNAGCSAAVLaEVHSRPVHRICQ-NKGSSFVAqhslaynlfltaAVGDG-IRLWDLRNLRCVRCFEGHP 751
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFsPDGEKLLS------------SSSDGtIKLWDLSTGKCLGTLRGHE 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569001632 752 NRSypCGVAFSPCGRLMACGAEDRHAYVYEMGSSSFLHRLAGHTDTITEVAFNPAAPQLSSG 813
Cdd:cd00200  220 NGV--NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-235 2.26e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 2.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632  47 DGSrLCVWSSKDPShQLLTLQGHHQLITAVVFgNQIDPLLLCSASEDYIIMWNVAECRE-KTLKGLTprgtilgsllQTV 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAF-SPDGTFVASSSQDGTIKLWDLRTGKCvATLTGHT----------GEV 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 126 LCLRFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPWQaHTLISVSEDRSFKVWDFCVGSLIYSssi 204
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQT--- 256

                        170       180       190
                 ....*....|....*....|....*....|...
gi 569001632 205 LTAY--PLLNLLINEENQQLVTGSADGQLWIFS 235
Cdd:cd00200  257 LSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
43-236 5.55e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 5.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632  43 AFPLDGSRL---------CVWSSKDPShQLLTLQGHHQLITAVVFGNqiDPLLLCSASEDYIIM-WNVAECRE-KTLKGL 111
Cdd:COG2319  211 AFSPDGKLLasgsadgtvRLWDLATGK-LLRTLTGHSGSVRSVAFSP--DGRLLASGSADGTVRlWDLATGELlRTLTGH 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 112 TPRgtilgsllqtVLCLRFSLDDRAIAV-CAGNKISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKV 190
Cdd:COG2319  288 SGG----------VNSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRL 356

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 569001632 191 WDFCVGSLIYSssiLTAY--PLLNLLINEENQQLVTGSADGQLWIFSL 236
Cdd:COG2319  357 WDLATGELLRT---LTGHtgAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 pfam00400
WD domain, G-beta repeat;
549-581 5.41e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 5.41e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 569001632  549 FSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWS 581
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 549-581 7.59e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 7.59e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 569001632   549 FSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWS 581
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 152-192 7.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 7.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 569001632   152 KQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWD 192
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
154-192 1.07e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 569001632  154 SVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWD 192
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
513-813 2.09e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 2.09e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLa 592
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL- 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 593 pDAFPKPVTSAQFYyMDTFILLSSGpefcllkyhidlcRDD-IRRYKPKSRyKPIFRLPMTSGAdITSLSAVNDfySHIV 671
Cdd:COG2319  201 -TGHTGAVRSVAFS-PDGKLLASGS-------------ADGtVRLWDLATG-KLLRTLTGHSGS-VRSVAFSPD--GRLL 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 672 LTAGRDRAVEVFDLNAGCSAAVLAEvHSRPVHricqnkgssfvaqhSLAY----NLFLTAAVGDGIRLWDLRNLRCVRCF 747
Cdd:COG2319  262 ASGSADGTVRLWDLATGELLRTLTG-HSGGVN--------------SVAFspdgKLLASGSDDGTVRLWDLATGKLLRTL 326

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569001632 748 EGHPNRSYpcGVAFSPCGRLMACGAEDRHAYVYEMGSSSFLHRLAGHTDTITEVAFNPAAPQLSSG 813
Cdd:COG2319  327 TGHTGAVR--SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-813 2.76e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.59  E-value: 2.76e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 514 VSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLAp 593
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 594 dAFPKPVTSAQFYYMDTFILLSSGPEFCLLkyhidlcrDDIRRYKPKSRYKPIfrlpmtsGADITSLSAvnDFYSHIVLT 673
Cdd:cd00200   91 -GHTSYVSSVAFSPDGRILSSSSRDKTIKV--------WDVETGKCLTTLRGH-------TDWVNSVAF--SPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 674 AGRDRAVEVFDLNAGCSAAVLaEVHSRPVHRICQ-NKGSSFVAqhslaynlfltaAVGDG-IRLWDLRNLRCVRCFEGHP 751
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFsPDGEKLLS------------SSSDGtIKLWDLSTGKCLGTLRGHE 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569001632 752 NRSypCGVAFSPCGRLMACGAEDRHAYVYEMGSSSFLHRLAGHTDTITEVAFNPAAPQLSSG 813
Cdd:cd00200  220 NGV--NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
513-805 1.37e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 1.37e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLA 592
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 593 PDAfpKPVTSAQFyymdtfillssgpefcllkyhidlcrddirrykpksrykpifrlpmtsGADitslsavndfySHIVL 672
Cdd:COG2319  160 GHS--GAVTSVAF------------------------------------------------SPD-----------GKLLA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 673 TAGRDRAVEVFDLNAGCSAAVLaEVHSRPVHricqnkgssfvaqhSLAY----NLFLTAAVGDGIRLWDLRNLRCVRCFE 748
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLLRTL-TGHTGAVR--------------SVAFspdgKLLASGSADGTVRLWDLATGKLLRTLT 243

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569001632 749 GHPNRSYpcGVAFSPCGRLMACGAEDRHAYVYEMGSSSFLHRLAGHTDTITEVAFNP 805
Cdd:COG2319  244 GHSGSVR--SVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 547-805 1.49e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.50  E-value: 1.49e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 547 AAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLApdAFPKPVTSAQFYYMDTFILLSSGPefcllkyh 626
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGTYLASGSSD-------- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 627 idlcrDDIRRYKPKSRyKPIFRLPMTSGaDITSLSAVNDfySHIVLTAGRDRAVEVFDLNAG-CSAAVLAevHSRPVHRI 705
Cdd:cd00200   73 -----KTIRLWDLETG-ECVRTLTGHTS-YVSSVAFSPD--GRILSSSSRDKTIKVWDVETGkCLTTLRG--HTDWVNSV 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 706 CQNKGSSFVAqhslaynlfltAAVGDG-IRLWDLRNLRCVRCFEGHpnRSYPCGVAFSPCGRLMACGAEDRHAYVYEMGS 784
Cdd:cd00200  142 AFSPDGTFVA-----------SSSQDGtIKLWDLRTGKCVATLTGH--TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                        250       260
                 ....*....|....*....|.
gi 569001632 785 SSFLHRLAGHTDTITEVAFNP 805
Cdd:cd00200  209 GKCLGTLRGHENGVNSVAFSP 229
WD40 COG2319
WD40 repeat [General function prediction only];
513-784 7.39e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.07  E-value: 7.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLA 592
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 593 PDAFPkpVTSAQFYyMDTFILLSSGpefcllkyhidlcRDD-IRRYKPKSRyKPIFRLPMTSGAdITSLSAVNDfySHIV 671
Cdd:COG2319  244 GHSGS--VRSVAFS-PDGRLLASGS-------------ADGtVRLWDLATG-ELLRTLTGHSGG-VNSVAFSPD--GKLL 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 672 LTAGRDRAVEVFDLNAGCSAAVLAEvHSRPVHRICQNKGSSFVAqhslaynlflTAAVGDGIRLWDLRNLRCVRCFEGHP 751
Cdd:COG2319  304 ASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLA----------SGSDDGTVRLWDLATGELLRTLTGHT 372

                        250       260       270
                 ....*....|....*....|....*....|...
gi 569001632 752 NRSYpcGVAFSPCGRLMACGAEDRHAYVYEMGS 784
Cdd:COG2319  373 GAVT--SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
499-813 8.31e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.75  E-value: 8.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 499 RNLSRQVAVAQKPVAVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLR 578
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 579 VWSVHRTELMLLLApdAFPKPVTSAQFyymdtfillSSGpefcllkyhidlcrddirrykpksrykpifrlpmtsgadit 658
Cdd:COG2319  104 LWDLATGLLLRTLT--GHTGAVRSVAF---------SPD----------------------------------------- 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 659 slsavndfySHIVLTAGRDRAVEVFDLNAGCSAAVLAEvHSRPVHricqnkgssfvaqhSLAY----NLFLTAAVGDGIR 734
Cdd:COG2319  132 ---------GKTLASGSADGTVRLWDLATGKLLRTLTG-HSGAVT--------------SVAFspdgKLLASGSDDGTVR 187

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569001632 735 LWDLRNLRCVRCFEGHPNRSYpcGVAFSPCGRLMACGAEDRHAYVYEMGSSSFLHRLAGHTDTITEVAFNPAAPQLSSG 813
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVR--SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 513-774 1.00e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLa 592
Cdd:cd00200   53 PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL- 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 593 pDAFPKPVTSAQFYYMDTFIllSSGpefcllkyhidlCRDD-IRRYKPKSRyKPIFRLPMTSGaDITSLSAVNDFYShiV 671
Cdd:cd00200  132 -RGHTDWVNSVAFSPDGTFV--ASS------------SQDGtIKLWDLRTG-KCVATLTGHTG-EVNSVAFSPDGEK--L 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 672 LTAGRDRAVEVFDLNAGCSAAVLaEVHSRPVHRICQNKGssfvaqhslayNLFLTAAVGDG-IRLWDLRNLRCVRCFEGH 750
Cdd:cd00200  193 LSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSPD-----------GYLLASGSEDGtIRVWDLRTGECVQTLSGH 260

                        250       260
                 ....*....|....*....|....
gi 569001632 751 PNRSYpcGVAFSPCGRLMACGAED 774
Cdd:cd00200  261 TNSVT--SLAWSPDGKRLASGSAD 282
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-235 2.26e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 2.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632  47 DGSrLCVWSSKDPShQLLTLQGHHQLITAVVFgNQIDPLLLCSASEDYIIMWNVAECRE-KTLKGLTprgtilgsllQTV 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAF-SPDGTFVASSSQDGTIKLWDLRTGKCvATLTGHT----------GEV 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 126 LCLRFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPWQaHTLISVSEDRSFKVWDFCVGSLIYSssi 204
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQT--- 256

                        170       180       190
                 ....*....|....*....|....*....|...
gi 569001632 205 LTAY--PLLNLLINEENQQLVTGSADGQLWIFS 235
Cdd:cd00200  257 LSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
43-236 5.55e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 5.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632  43 AFPLDGSRL---------CVWSSKDPShQLLTLQGHHQLITAVVFGNqiDPLLLCSASEDYIIM-WNVAECRE-KTLKGL 111
Cdd:COG2319  211 AFSPDGKLLasgsadgtvRLWDLATGK-LLRTLTGHSGSVRSVAFSP--DGRLLASGSADGTVRlWDLATGELlRTLTGH 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 112 TPRgtilgsllqtVLCLRFSLDDRAIAV-CAGNKISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKV 190
Cdd:COG2319  288 SGG----------VNSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRL 356

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 569001632 191 WDFCVGSLIYSssiLTAY--PLLNLLINEENQQLVTGSADGQLWIFSL 236
Cdd:COG2319  357 WDLATGELLRT---LTGHtgAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 655-814 1.01e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 1.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 655 ADITSLSAVNDfySHIVLTAGRDRAVEVFDLNAGCSAAVLaEVHSRPVHRIcqnkgsSFVAQHslayNLFLTAAVGDGIR 734
Cdd:cd00200   10 GGVTCVAFSPD--GKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDV------AASADG----TYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 735 LWDLRNLRCVRCFEGHpnRSYPCGVAFSPCGRLMACGAEDRHAYVYEMGSSSFLHRLAGHTDTITEVAFNPAAPQLSSGK 814
Cdd:cd00200   77 LWDLETGECVRTLTGH--TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154
WD40 COG2319
WD40 repeat [General function prediction only];
9-236 2.41e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 2.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632   9 STDGHTRAIVTERYVVESKKSAAHVPLACSTQH------CAFPLDGSRL---------CVWSSKDPShQLLTLQGHHQLI 73
Cdd:COG2319   87 SPDGRLLASASADGTVRLWDLATGLLLRTLTGHtgavrsVAFSPDGKTLasgsadgtvRLWDLATGK-LLRTLTGHSGAV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632  74 TAVVF---GNqidpLLLcSASEDY-IIMWNVAECRE-KTLKGLTPRgtilgsllqtVLCLRFSLDDRAIAVCAGNK-ISV 147
Cdd:COG2319  166 TSVAFspdGK----LLA-SGSDDGtVRLWDLATGKLlRTLTGHTGA----------VRSVAFSPDGKLLASGSADGtVRL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 148 MDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWDFCVGSLIYSSSILTAyPLLNLLINEENQQLVTGSA 227
Cdd:COG2319  231 WDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSD 308


                 ....*....
gi 569001632 228 DGQLWIFSL 236
Cdd:COG2319  309 DGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 65-257 4.42e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 4.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632  65 TLQGHHQLITAVVFGNqiDPLLLCSASED-YIIMWNVAECR-EKTLKGLTprgtilgsllQTVLCLRFSLDDRAIAVCAG 142
Cdd:cd00200    4 TLKGHTGGVTCVAFSP--DGKLLATGSGDgTIKVWDLETGElLRTLKGHT----------GPVRDVAASADGTYLASGSS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 143 NK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWDFCVGSLIYSssiLTAY--PLLNLLINEEN 219
Cdd:cd00200   72 DKtIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTT---LRGHtdWVNSVAFSPDG 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 569001632 220 QQLVTGSADGQLWIFSLMEG-------HHYHCVAHVDVRKKRETF 257
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGkcvatltGHTGEVNSVAFSPDGEKL 192
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-239 5.63e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 5.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632  40 QHCAFPLDGSRLC---------VWSSKDPsHQLLTLQGHHQLITAVVFGNqiDPLLLCSASEDY-IIMWNVAECR-EKTL 108
Cdd:cd00200   55 RDVAASADGTYLAsgssdktirLWDLETG-ECVRTLTGHTSYVSSVAFSP--DGRILSSSSRDKtIKVWDVETGKcLTTL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 109 KGLTprgtilgsllQTVLCLRFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRS 187
Cdd:cd00200  132 RGHT----------DWVNSVAFSPDGTFVASSSQDGtIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGT 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 569001632 188 FKVWDF----CVGSLIYSSSILTAypllnLLINEENQQLVTGSADGQLWIFSLMEG 239
Cdd:cd00200  201 IKLWDLstgkCLGTLRGHENGVNS-----VAFSPDGYLLASGSEDGTIRVWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-247 5.12e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 5.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632  42 CAFPLDGSRLC---------VWSSKDPShQLLTLQGHHQLITAVVFGNQiDPLLLCSASEDYIIMWNvaecrektLKGLT 112
Cdd:cd00200   15 VAFSPDGKLLAtgsgdgtikVWDLETGE-LLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWD--------LETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 113 PRGTILGSLlQTVLCLRFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVW 191
Cdd:cd00200   85 CVRTLTGHT-SYVSSVAFSPDGRILSSSSRDKtIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLW 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569001632 192 DFCVGSLIYSSSILTAyPLLNLLINEENQQLVTGSADGQLWIFSLMEGHHYH-CVAH 247
Cdd:cd00200  163 DLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGH 218
WD40 COG2319
WD40 repeat [General function prediction only];
46-582 1.39e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 1.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632  46 LDGSRLCVWSSKDPSHQLLTLQGHHQLITAVVFgnQIDPLLLCSASEDYII-MWNVAEcrektlkglTPRGTILGSLLQT 124
Cdd:COG2319   54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF--SPDGRLLASASADGTVrLWDLAT---------GLLLRTLTGHTGA 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 125 VLCLRFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWDFCVGSLIYSss 203
Cdd:COG2319  123 VRSVAFSPDGKTLASGSADGtVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRT-- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 204 iLTAY--PLLNLLINEENQQLVTGSADG--QLWifslmeghhyhcvahvDVRKKRETFTtrrmmaeqcslPEDHqcrcrh 279
Cdd:COG2319  200 -LTGHtgAVRSVAFSPDGKLLASGSADGtvRLW----------------DLATGKLLRT-----------LTGH------ 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 280 eadkrgeaeaTFPILSLApcdlCLPDSQRGAFASE-CTKCLWigsstalfilNLASFELEAALHFKEFQSLSVqvagsca 358
Cdd:COG2319  246 ----------SGSVRSVA----FSPDGRLLASGSAdGTVRLW----------DLATGELLRTLTGHSGGVNSV------- 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 359 mvsepmsakAFcmlsSMFGSKIAVLEIDlaallstqqypragkvlsvlasscvlptsplyfGIIKekfpklantkqhavk 438
Cdd:COG2319  295 ---------AF----SPDGKLLASGSDD---------------------------------GTVR--------------- 313

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001632 439 svvedrplVFHTKVRSSGYTLAPHmamfspktnikhhnkrsskyknnykckecslenflprnlsrqvavaqkPVAVSCLQ 518
Cdd:COG2319  314 --------LWDLATGKLLRTLTGH------------------------------------------------TGAVRSVA 337

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569001632 519 FSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSV 582
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 pfam00400
WD domain, G-beta repeat;
549-581 5.41e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 5.41e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 569001632  549 FSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWS 581
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 549-581 7.59e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 7.59e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 569001632   549 FSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWS 581
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 152-192 7.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 7.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 569001632   152 KQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWD 192
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
154-192 1.07e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 569001632  154 SVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWD 192
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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