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Conserved domains on  [gi|569004338|ref|XP_006526229|]
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piezo-type mechanosensitive ion channel component 2 isoform X1 [Mus musculus]

Protein Classification

piezo-type mechanosensitive ion channel component( domain architecture ID 11239826)

piezo-type mechanosensitive ion channel component is a pore-forming subunit of a mechanosensitive non-specific cation channel, similar to human PIEZO1 and PIEZO2

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Piezo_RRas_bdg pfam12166
Piezo non-specific cation channel, R-Ras-binding domain; This is an extracellular domain at ...
2431-2840 0e+00

Piezo non-specific cation channel, R-Ras-binding domain; This is an extracellular domain at the C-terminus of Piezo, or FAM38 mechanosensitive non-specific cation channel proteins. It seems likely that this region of the Piezo proteins may be responsible for R-Ras recruitment because this region is capable of relocalising R-Ras to the ER in eukaryotes.


:

Pssm-ID: 463481  Cd Length: 415  Bit Score: 592.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2431 LVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKrYPQPR-GQKKKKAVKYGMGGMIIVLLICIVWF 2509
Cdd:pfam12166    1 AIPFLFELRTLLDWTWTDTSLTLFDWFKLEDIYANLFKVKCDRESEK-YPQPKlGQKQPKVVKYGMGGLILIALILIIWF 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2510 PLLFMSLIKSVaGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAE 2589
Cdd:pfam12166   80 PLLLFSSLNPV-GVPNPPTDVSVSISIGGYEPLFTMSAQQNNLPLFTDSEFDNLTQIYAPSPSAMGFLSNYDKEDIQLIK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2590 LEGNSNSLWTISPPSKQKMIQEL--TDPNSCFSVVFSWSIQRNMTLGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTES 2667
Cdd:pfam12166  159 LSSFSSSLWTISPPSRNQLIQELsnNTTNSSFTLTVTWTFTRDGPSGKETVEYVTKNSVPLPPEQRKQLAQMLNGTQTDQ 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2668 SNtPVTIEKIYPYYVKAP-SDSNSKPIKQLLSENNFMNITIILFRDNVTKSNSEWWVLN---LTGSRIFNQGSQALELVV 2743
Cdd:pfam12166  239 PV-SVILPNLYPKFLRLPgSGGAAKPSSQLYELAAFRNVTLTLNRSNNSNSSQEWWSISeakITSNSGCDSGSGGLEFVV 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2744 FNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYA 2822
Cdd:pfam12166  318 FSDKVSPGSLGsFLSGYGIIGLYTSVVLVIGRFIRSFFSGISHRIMFEELPNPDRLLKLCEDIYLAREEGDLELEEDLYA 397
                          410
                   ....*....|....*...
gi 569004338  2823 KLIFLYRSPETMIKWTRE 2840
Cdd:pfam12166  398 KLIFLYRSPETLIKWTGE 415
PIEZO pfam15917
Piezo; This domain is found in proteins belonging to the piezo family. Piezo proteins are ...
1369-1636 4.71e-112

Piezo; This domain is found in proteins belonging to the piezo family. Piezo proteins are components of cation channels. This domain is found in association with pfam12166.


:

Pssm-ID: 464941  Cd Length: 223  Bit Score: 355.46  E-value: 4.71e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  1369 GACGYIGALVRNSCWLIQAFSLACTVKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQ 1448
Cdd:pfam15917    1 LACVFLEQLQKNFCWVIQLFSLVCTVKGYYDPDFDKDCELPVEEAGIIWDSICFAFLLLQRRVFLSYYFLHVVADLRASA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  1449 ILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKermlsltQESGEGQdiqkVSEEDDEREADK 1528
Cdd:pfam15917   81 ILASRGAELFNASIVKSIKARLEAEKKSLEQLKRQMERIKAKQQKYRQGR-------QGSGEPQ----VPSEDQPIEAGG 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  1529 QKAKGKKKQWWRPWVDHASMVRSGDYYLFETDSEEEEEEELKKEDEePPRKSAFQraigkfasailalpksviklpktil 1608
Cdd:pfam15917  150 AERDGEKKKWWRPWVDHASVVRSGDYYLFESDSEEEEEEEEKEEER-PKKKSAFQ------------------------- 203
                          250       260
                   ....*....|....*....|....*...
gi 569004338  1609 qyliraakFVYQAWITDPKTALRQRRKE 1636
Cdd:pfam15917  204 --------LAYQAWVTDAKTALRVRQQE 223
 
Name Accession Description Interval E-value
Piezo_RRas_bdg pfam12166
Piezo non-specific cation channel, R-Ras-binding domain; This is an extracellular domain at ...
2431-2840 0e+00

Piezo non-specific cation channel, R-Ras-binding domain; This is an extracellular domain at the C-terminus of Piezo, or FAM38 mechanosensitive non-specific cation channel proteins. It seems likely that this region of the Piezo proteins may be responsible for R-Ras recruitment because this region is capable of relocalising R-Ras to the ER in eukaryotes.


Pssm-ID: 463481  Cd Length: 415  Bit Score: 592.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2431 LVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKrYPQPR-GQKKKKAVKYGMGGMIIVLLICIVWF 2509
Cdd:pfam12166    1 AIPFLFELRTLLDWTWTDTSLTLFDWFKLEDIYANLFKVKCDRESEK-YPQPKlGQKQPKVVKYGMGGLILIALILIIWF 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2510 PLLFMSLIKSVaGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAE 2589
Cdd:pfam12166   80 PLLLFSSLNPV-GVPNPPTDVSVSISIGGYEPLFTMSAQQNNLPLFTDSEFDNLTQIYAPSPSAMGFLSNYDKEDIQLIK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2590 LEGNSNSLWTISPPSKQKMIQEL--TDPNSCFSVVFSWSIQRNMTLGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTES 2667
Cdd:pfam12166  159 LSSFSSSLWTISPPSRNQLIQELsnNTTNSSFTLTVTWTFTRDGPSGKETVEYVTKNSVPLPPEQRKQLAQMLNGTQTDQ 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2668 SNtPVTIEKIYPYYVKAP-SDSNSKPIKQLLSENNFMNITIILFRDNVTKSNSEWWVLN---LTGSRIFNQGSQALELVV 2743
Cdd:pfam12166  239 PV-SVILPNLYPKFLRLPgSGGAAKPSSQLYELAAFRNVTLTLNRSNNSNSSQEWWSISeakITSNSGCDSGSGGLEFVV 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2744 FNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYA 2822
Cdd:pfam12166  318 FSDKVSPGSLGsFLSGYGIIGLYTSVVLVIGRFIRSFFSGISHRIMFEELPNPDRLLKLCEDIYLAREEGDLELEEDLYA 397
                          410
                   ....*....|....*...
gi 569004338  2823 KLIFLYRSPETMIKWTRE 2840
Cdd:pfam12166  398 KLIFLYRSPETLIKWTGE 415
PIEZO pfam15917
Piezo; This domain is found in proteins belonging to the piezo family. Piezo proteins are ...
1369-1636 4.71e-112

Piezo; This domain is found in proteins belonging to the piezo family. Piezo proteins are components of cation channels. This domain is found in association with pfam12166.


Pssm-ID: 464941  Cd Length: 223  Bit Score: 355.46  E-value: 4.71e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  1369 GACGYIGALVRNSCWLIQAFSLACTVKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQ 1448
Cdd:pfam15917    1 LACVFLEQLQKNFCWVIQLFSLVCTVKGYYDPDFDKDCELPVEEAGIIWDSICFAFLLLQRRVFLSYYFLHVVADLRASA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  1449 ILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKermlsltQESGEGQdiqkVSEEDDEREADK 1528
Cdd:pfam15917   81 ILASRGAELFNASIVKSIKARLEAEKKSLEQLKRQMERIKAKQQKYRQGR-------QGSGEPQ----VPSEDQPIEAGG 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  1529 QKAKGKKKQWWRPWVDHASMVRSGDYYLFETDSEEEEEEELKKEDEePPRKSAFQraigkfasailalpksviklpktil 1608
Cdd:pfam15917  150 AERDGEKKKWWRPWVDHASVVRSGDYYLFESDSEEEEEEEEKEEER-PKKKSAFQ------------------------- 203
                          250       260
                   ....*....|....*....|....*...
gi 569004338  1609 qyliraakFVYQAWITDPKTALRQRRKE 1636
Cdd:pfam15917  204 --------LAYQAWVTDAKTALRVRQQE 223
 
Name Accession Description Interval E-value
Piezo_RRas_bdg pfam12166
Piezo non-specific cation channel, R-Ras-binding domain; This is an extracellular domain at ...
2431-2840 0e+00

Piezo non-specific cation channel, R-Ras-binding domain; This is an extracellular domain at the C-terminus of Piezo, or FAM38 mechanosensitive non-specific cation channel proteins. It seems likely that this region of the Piezo proteins may be responsible for R-Ras recruitment because this region is capable of relocalising R-Ras to the ER in eukaryotes.


Pssm-ID: 463481  Cd Length: 415  Bit Score: 592.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2431 LVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKrYPQPR-GQKKKKAVKYGMGGMIIVLLICIVWF 2509
Cdd:pfam12166    1 AIPFLFELRTLLDWTWTDTSLTLFDWFKLEDIYANLFKVKCDRESEK-YPQPKlGQKQPKVVKYGMGGLILIALILIIWF 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2510 PLLFMSLIKSVaGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAE 2589
Cdd:pfam12166   80 PLLLFSSLNPV-GVPNPPTDVSVSISIGGYEPLFTMSAQQNNLPLFTDSEFDNLTQIYAPSPSAMGFLSNYDKEDIQLIK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2590 LEGNSNSLWTISPPSKQKMIQEL--TDPNSCFSVVFSWSIQRNMTLGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTES 2667
Cdd:pfam12166  159 LSSFSSSLWTISPPSRNQLIQELsnNTTNSSFTLTVTWTFTRDGPSGKETVEYVTKNSVPLPPEQRKQLAQMLNGTQTDQ 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2668 SNtPVTIEKIYPYYVKAP-SDSNSKPIKQLLSENNFMNITIILFRDNVTKSNSEWWVLN---LTGSRIFNQGSQALELVV 2743
Cdd:pfam12166  239 PV-SVILPNLYPKFLRLPgSGGAAKPSSQLYELAAFRNVTLTLNRSNNSNSSQEWWSISeakITSNSGCDSGSGGLEFVV 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  2744 FNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYA 2822
Cdd:pfam12166  318 FSDKVSPGSLGsFLSGYGIIGLYTSVVLVIGRFIRSFFSGISHRIMFEELPNPDRLLKLCEDIYLAREEGDLELEEDLYA 397
                          410
                   ....*....|....*...
gi 569004338  2823 KLIFLYRSPETMIKWTRE 2840
Cdd:pfam12166  398 KLIFLYRSPETLIKWTGE 415
PIEZO pfam15917
Piezo; This domain is found in proteins belonging to the piezo family. Piezo proteins are ...
1369-1636 4.71e-112

Piezo; This domain is found in proteins belonging to the piezo family. Piezo proteins are components of cation channels. This domain is found in association with pfam12166.


Pssm-ID: 464941  Cd Length: 223  Bit Score: 355.46  E-value: 4.71e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  1369 GACGYIGALVRNSCWLIQAFSLACTVKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQ 1448
Cdd:pfam15917    1 LACVFLEQLQKNFCWVIQLFSLVCTVKGYYDPDFDKDCELPVEEAGIIWDSICFAFLLLQRRVFLSYYFLHVVADLRASA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  1449 ILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKermlsltQESGEGQdiqkVSEEDDEREADK 1528
Cdd:pfam15917   81 ILASRGAELFNASIVKSIKARLEAEKKSLEQLKRQMERIKAKQQKYRQGR-------QGSGEPQ----VPSEDQPIEAGG 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004338  1529 QKAKGKKKQWWRPWVDHASMVRSGDYYLFETDSEEEEEEELKKEDEePPRKSAFQraigkfasailalpksviklpktil 1608
Cdd:pfam15917  150 AERDGEKKKWWRPWVDHASVVRSGDYYLFESDSEEEEEEEEKEEER-PKKKSAFQ------------------------- 203
                          250       260
                   ....*....|....*....|....*...
gi 569004338  1609 qyliraakFVYQAWITDPKTALRQRRKE 1636
Cdd:pfam15917  204 --------LAYQAWVTDAKTALRVRQQE 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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