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Conserved domains on  [gi|569006455|ref|XP_006526768|]
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interferon-induced protein with tetratricopeptide repeats 2 isoform X1 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 1000094)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 152-282 1.50e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 76.19  E-value: 1.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 152 NQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLALKLDAVHK-NQAMAL 230
Cdd:COG3914   92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE---ALAALRRALALNPDFAEAYLNLGEALRRLGRlEEAIAA 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569006455 231 VEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYM 282
Cdd:COG3914  169 LRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 151-422 5.06e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 68.99  E-value: 5.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 151 KNQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLA-LKLDAVHKNQAMA 229
Cdd:COG2956   21 NGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDR---AIRIHQKLLERDPDRAEALLELAqDYLKAGLLDRAEE 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 230 LVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRSKvhhmlnrremvfsGDRKKle 309
Cdd:COG2956   98 LLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQ-------------GDYDE-- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 310 eliqlAVNHLRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKELSKDlpPGPKQLLHLRYGNFQffQMKRQDKAIY 389
Cdd:COG2956  163 -----AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYE--KLGDPEEALE 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 569006455 390 HYMEGVKIKK---------KTIPQKKMREKLQRIALRRLHED 422
Cdd:COG2956  234 LLRKALELDPsddlllalaDLLERKEGLEAALALLERQLRRH 275
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 83-208 4.37e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 4.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  83 QQHPDQVEirslvTWGNYAWVYYHMGQFSKAQAYLDKVkqvckkfsspYRI--ENPALdcEEGWARLKCTKNQNERVKVC 160
Cdd:COG4235   11 AANPNDAE-----GWLLLGRAYLRLGRYDEALAAYEKA----------LRLdpDNADA--LLDLAEALLAAGDTEEAEEL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 569006455 161 FQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDN 208
Cdd:COG4235   74 LERALALDPDNPEALYLLGLAAFQQGDYAE---AIAAWQKLLALLPAD 118
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 152-282 1.50e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 76.19  E-value: 1.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 152 NQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLALKLDAVHK-NQAMAL 230
Cdd:COG3914   92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE---ALAALRRALALNPDFAEAYLNLGEALRRLGRlEEAIAA 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569006455 231 VEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYM 282
Cdd:COG3914  169 LRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 151-422 5.06e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 68.99  E-value: 5.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 151 KNQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLA-LKLDAVHKNQAMA 229
Cdd:COG2956   21 NGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDR---AIRIHQKLLERDPDRAEALLELAqDYLKAGLLDRAEE 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 230 LVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRSKvhhmlnrremvfsGDRKKle 309
Cdd:COG2956   98 LLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQ-------------GDYDE-- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 310 eliqlAVNHLRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKELSKDlpPGPKQLLHLRYGNFQffQMKRQDKAIY 389
Cdd:COG2956  163 -----AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYE--KLGDPEEALE 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 569006455 390 HYMEGVKIKK---------KTIPQKKMREKLQRIALRRLHED 422
Cdd:COG2956  234 LLRKALELDPsddlllalaDLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 145-359 1.05e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.24  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  145 ARLKCTKNQNERVKVCFQKALEKDPKNPEFTSGWAiANYRLDDWPARnyCIDSLEQAIQLSPDN-TYVKVLLALKLDAVH 223
Cdd:TIGR02917 540 AGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALA-QYYLGKGQLKK--ALAILNEAADAAPDSpEAWLMLGRAQLAAGD 616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  224 KNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAyvhyymgccyrskvhhMLNRREMVFSG 303
Cdd:TIGR02917 617 LNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNT----------------EAQIGLAQLLL 680

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569006455  304 DRKKLEELIQLAvnhlRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKELSK 359
Cdd:TIGR02917 681 AAKRTESAKKIA----KSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKR 732
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 83-208 4.37e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 4.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  83 QQHPDQVEirslvTWGNYAWVYYHMGQFSKAQAYLDKVkqvckkfsspYRI--ENPALdcEEGWARLKCTKNQNERVKVC 160
Cdd:COG4235   11 AANPNDAE-----GWLLLGRAYLRLGRYDEALAAYEKA----------LRLdpDNADA--LLDLAEALLAAGDTEEAEEL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 569006455 161 FQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDN 208
Cdd:COG4235   74 LERALALDPDNPEALYLLGLAAFQQGDYAE---AIAAWQKLLALLPAD 118
TPR_19 pfam14559
Tetratricopeptide repeat;
225-279 1.45e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 39.87  E-value: 1.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 569006455  225 NQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVH 279
Cdd:pfam14559   5 AEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYA 59
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 196-432 1.05e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  196 DSLEQAIQLSPDNTYVK-----VLLALKLDAV----HKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLR 266
Cdd:TIGR02917 104 GKFQQVLDELPGKTLLDdegaaELLALRGLAYlglgQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALID 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  267 KALEKLPNNAYVHYYMGCCYRSK--------------------VHHMLNR-----REMVFSGDRKKLEELIQLAVNHLrK 321
Cdd:TIGR02917 184 EVLTADPGNVDALLLKGDLLLSLgnielalaayrkaialrpnnIAVLLALatiliEAGEFEEAEKHADALLKKAPNSP-L 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  322 AEEIKEMLEYScsfladlyiiAKKYDEADYYFQKELSKDlppgPKQLLHLRYGNFQFFQMKRQDKAIYHYMEGVKIKKKT 401
Cdd:TIGR02917 263 AHYLKALVDFQ----------KKNYEDARETLQDALKSA----PEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNS 328

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 569006455  402 IPQKKM------REKLQRIALRRLH----EDESDSEALHIL 432
Cdd:TIGR02917 329 HQARRLlasiqlRLGRVDEAIATLSpalgLDPDDPAALSLL 369
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 155-288 2.23e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 155 ERVKVCFQKALEKDPKNPEFTSgwAIANYRLddwparnyCIDSLEQAIQlspdntYVKVLLALKLDAVHKNQAMALVEEA 234
Cdd:cd24142  143 QRCEELITKALELDPTNPEALQ--TLASLRI--------SQQRPDEAKE------ALRRSLELWKDLKEEDEEEAEEDEA 206

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 569006455 235 LKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRS 288
Cdd:cd24142  207 EEEDVPSYEFRISLAKLLIELEMYEEALEVLEQLLDEDDEDVEVWYLLGWAYYL 260
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 226-340 2.39e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 226 QAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHY-YMG---------CCYRSKVHHMln 295
Cdd:cd24142   18 LALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEKYlYLGqlsggeealQYYEKGIEIL-- 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 569006455 296 rremvfsgdRKKLEELIQLAVNHLRKAEEIKEMLEYSCSFLADLY 340
Cdd:cd24142   96 ---------EEELQALQAASAEAEEEAEELKRKLSSALCALAEIY 131
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 152-282 1.50e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 76.19  E-value: 1.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 152 NQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLALKLDAVHK-NQAMAL 230
Cdd:COG3914   92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE---ALAALRRALALNPDFAEAYLNLGEALRRLGRlEEAIAA 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569006455 231 VEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYM 282
Cdd:COG3914  169 LRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 151-422 5.06e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 68.99  E-value: 5.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 151 KNQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLA-LKLDAVHKNQAMA 229
Cdd:COG2956   21 NGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDR---AIRIHQKLLERDPDRAEALLELAqDYLKAGLLDRAEE 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 230 LVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRSKvhhmlnrremvfsGDRKKle 309
Cdd:COG2956   98 LLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQ-------------GDYDE-- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 310 eliqlAVNHLRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKELSKDlpPGPKQLLHLRYGNFQffQMKRQDKAIY 389
Cdd:COG2956  163 -----AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYE--KLGDPEEALE 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 569006455 390 HYMEGVKIKK---------KTIPQKKMREKLQRIALRRLHED 422
Cdd:COG2956  234 LLRKALELDPsddlllalaDLLERKEGLEAALALLERQLRRH 275
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 160-276 1.04e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 65.03  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 160 CFQKALEKDPKNPEftsGW---AIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLALKLDAVHKN-QAMALVEEAL 235
Cdd:COG4235    5 RLRQALAANPNDAE---GWlllGRAYLRLGRYDE---ALAAYEKALRLDPDNADALLDLAEALLAAGDTeEAEELLERAL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 569006455 236 KKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNA 276
Cdd:COG4235   79 ALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADA 119
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 145-275 3.61e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.98  E-value: 3.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 145 ARLKCTKNQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPARnycIDSLEQAIQLSPDNTYVKVLLALKLDAVHK 224
Cdd:COG4783   11 AQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEA---IVLLHEALELDPDEPEARLNLGLALLKAGD 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569006455 225 -NQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNN 275
Cdd:COG4783   88 yDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
96-377 4.34e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.10  E-value: 4.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  96 TWGNYAWVYYHMGQFSKAQAyldkvkqvckkfsspyrienpaldceegwarlkctknqnervkvCFQKALEKDPKNPEFT 175
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIE--------------------------------------------DYEKALELDPDDAEAL 45

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 176 SGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLALKLDAVHK-NQAMALVEEALKKDPSAIDTLLRAARFYCK 254
Cdd:COG0457   46 YNLGLAYLRLGRYEE---ALADYEQALELDPDDAEALNNLGLALQALGRyEEALEDYDKALELDPDDAEALYNLGLALLE 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 255 VYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRSKVHHMLNRREMVFSGDRKKLEELIQLAVNHLRKAEEIKEMLEYSCS 334
Cdd:COG0457  123 LGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLA 202

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 569006455 335 FLADLYIIAKKYDEADYYFQKELSKDLPPGPKQLLHLRYGNFQ 377
Cdd:COG0457  203 LEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
202-469 4.55e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.72  E-value: 4.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 202 IQLSPDNTYVKVLLALKLDAVHKNQ-AMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHY 280
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEeAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 281 YMGCCYRskvhhmlnrremvfsgDRKKLEEliqlAVNHLRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKELSKD 360
Cdd:COG0457   81 NLGLALQ----------------ALGRYEE----ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 361 lppgPKQLLHLRYGNFQFFQMKRQDKAIYHYMEGVKIKKKTIPQKKMREKLQRIALRRLHEDESDSEALHILAFLQENGG 440
Cdd:COG0457  141 ----PDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTL 216

                        250       260
                 ....*....|....*....|....*....
gi 569006455 441 GQQADKDSERGVDSANQVPSASLDEAGAE 469
Cdd:COG0457  217 AALAELLLLALALLLALRLAALALYQYRA 245
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 195-373 6.74e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 64.63  E-value: 6.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 195 IDSLEQAIQLSPDNTYVKVLLALKLDAVHK-NQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLP 273
Cdd:COG3914   98 LALYRRALALNPDNAEALFNLGNLLLALGRlEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDP 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 274 NNAYVHYYMGCCYRskvhhmlnrremvfsgDRKKLEEliqlAVNHLRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYF 353
Cdd:COG3914  178 DNAEALNNLGNALQ----------------DLGRLEE----AIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFE 237

                        170       180
                 ....*....|....*....|
gi 569006455 354 QKELSKDLPPGPKQLLHLRY 373
Cdd:COG3914  238 ELLAALARGPSELSPFALLY 257
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 179-287 3.09e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 3.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 179 AIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLA-LKLDAVHKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYD 257
Cdd:COG4783   11 AQALLLAGDYDE---AEALLEKALELDPDNPEAFALLGeILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGD 87

                         90       100       110
                 ....*....|....*....|....*....|
gi 569006455 258 TDRAIQLLRKALEKLPNNAYVHYYMGCCYR 287
Cdd:COG4783   88 YDEALALLEKALKLDPEHPEAYLRLARAYR 117
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 195-283 8.37e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.77  E-value: 8.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 195 IDSLEQAIQLSPDNTYVKVLLA-LKLDAVHKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLP 273
Cdd:COG4235    3 IARLRQALAANPNDAEGWLLLGrAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82

                         90
                 ....*....|
gi 569006455 274 NNAYVHYYMG 283
Cdd:COG4235   83 DNPEALYLLG 92
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 103-271 2.26e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 2.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 103 VYYHMGQFSKAQAYLDKVKQVCKkfsspyriENPALDCEegWARLKCTKNQNERVKVCFQKALEKDPKNPEFTSGWAIAN 182
Cdd:COG2956  119 IYEQEGDWEKAIEVLERLLKLGP--------ENAHAYCE--LAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELY 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 183 YRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLALKLDAVHKN-QAMALVEEALKKDPSaIDTLLRAARFYCKVYDTDRA 261
Cdd:COG2956  189 LEQGDYEE---AIAALERALEQDPDYLPALPRLAELYEKLGDPeEALELLRKALELDPS-DDLLLALADLLERKEGLEAA 264

                        170
                 ....*....|
gi 569006455 262 IQLLRKALEK 271
Cdd:COG2956  265 LALLERQLRR 274
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
55-270 3.77e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 3.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  55 NILAYVKHCRGLNEAALQCLGEAEgfiqQQHPDQVEirslvTWGNYAWVYYHMGQFSKAQAYLDKVKQVCKKFSSPYRie 134
Cdd:COG0457   12 NNLGLAYRRLGRYEEAIEDYEKAL----ELDPDDAE-----ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 135 npaldceeGWARLKCTKNQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVL 214
Cdd:COG0457   81 --------NLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE---AIEAYERALELDPDDADALYN 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569006455 215 LALKLDAVHK-NQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALE 270
Cdd:COG0457  150 LGIALEKLGRyEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 226-365 6.12e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.46  E-value: 6.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 226 QAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYrskvhhmlnrremVFSGDR 305
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEAL-------------LAAGDT 67

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 306 KKleeliqlAVNHLRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKELsKDLPPGP 365
Cdd:COG4235   68 EE-------AEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLL-ALLPADA 119
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 225-394 9.77e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 9.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 225 NQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRskvhhmlnrremvfsgD 304
Cdd:COG3914   95 EEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALR----------------R 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 305 RKKLEEliqlAVNHLRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQK--ELSKDLPPGPKQLLHLRYGNFQFFQMK 382
Cdd:COG3914  159 LGRLEE----AIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRalELDPDNADAHSNLLFALRQACDWEVYD 234

                        170
                 ....*....|..
gi 569006455 383 RQDKAIYHYMEG 394
Cdd:COG3914  235 RFEELLAALARG 246
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 145-359 1.05e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.24  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  145 ARLKCTKNQNERVKVCFQKALEKDPKNPEFTSGWAiANYRLDDWPARnyCIDSLEQAIQLSPDN-TYVKVLLALKLDAVH 223
Cdd:TIGR02917 540 AGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALA-QYYLGKGQLKK--ALAILNEAADAAPDSpEAWLMLGRAQLAAGD 616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  224 KNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAyvhyymgccyrskvhhMLNRREMVFSG 303
Cdd:TIGR02917 617 LNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNT----------------EAQIGLAQLLL 680

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569006455  304 DRKKLEELIQLAvnhlRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKELSK 359
Cdd:TIGR02917 681 AAKRTESAKKIA----KSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKR 732
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 240-398 2.16e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.11  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 240 SAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRskvhhmlnrremvfsgDRKKLEEliqlAVNHL 319
Cdd:COG4783    2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILL----------------QLGDLDE----AIVLL 61

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006455 320 RKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKELSKDlPPGPKqlLHLRYGNFqFFQMKRQDKAIYHYMEGVKIK 398
Cdd:COG4783   62 HEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD-PEHPE--AYLRLARA-YRALGRPDEAIAALEKALELD 136
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 172-391 2.25e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 172 PEFTSGWAIANYRLDDWPARNYCIDSLEQAIQLSPDNTYVKVLLALKLDAVHK-------NQAMALVEEALKKDPSAIDT 244
Cdd:COG3914    1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEaaaaallALAAGEAAAAAAALLLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 245 LLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRskvhhmlnrremvfsgDRKKLEEliqlAVNHLRKAEE 324
Cdd:COG3914   81 LELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLL----------------ALGRLEE----ALAALRRALA 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006455 325 IKEMLEYSCSFLADLYIIAKKYDEADYYFQKELSKDlppgPKQL-LHLRYGNFqFFQMKRQDKAIYHY 391
Cdd:COG3914  141 LNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD----PDNAeALNNLGNA-LQDLGRLEEAIAAY 203
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 150-359 2.61e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.08  E-value: 2.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  150 TKNQNERVKvCFQKALEKDPKNPEftsgwaiANYRLDD--WPARNY--CIDSLEQAIQLSPDNTYVKVLLA-LKLDAVHK 224
Cdd:TIGR02917 614 AGDLNKAVS-SFKKLLALQPDSAL-------ALLLLADayAVMKNYakAITSLKRALELKPDNTEAQIGLAqLLLAAKRT 685

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  225 NQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVhyymgccyrSKVHHMLnrremVFSGD 304
Cdd:TIGR02917 686 ESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNA---------IKLHRAL-----LASGN 751

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 569006455  305 RKKLEELIQLAVNhlRKAEEIKEMLeyscsFLADLYIIAKKYDEADYYFQKELSK 359
Cdd:TIGR02917 752 TAEAVKTLEAWLK--THPNDAVLRT-----ALAELYLAQKDYDKAIKHYQTVVKK 799
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 83-208 4.37e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 4.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  83 QQHPDQVEirslvTWGNYAWVYYHMGQFSKAQAYLDKVkqvckkfsspYRI--ENPALdcEEGWARLKCTKNQNERVKVC 160
Cdd:COG4235   11 AANPNDAE-----GWLLLGRAYLRLGRYDEALAAYEKA----------LRLdpDNADA--LLDLAEALLAAGDTEEAEEL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 569006455 161 FQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDN 208
Cdd:COG4235   74 LERALALDPDNPEALYLLGLAAFQQGDYAE---AIAAWQKLLALLPAD 118
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 103-360 7.17e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 7.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  103 VYYHMGQFSKAQAYLDKVKQVCKKFSSPYRIenpaldceegWARLKCTKNQNERVKVCFQKALEKDPKNPEFTSGWAIAN 182
Cdd:TIGR02917 304 SEYQLGNLEQAYQYLNQILKYAPNSHQARRL----------LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAY 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  183 YRLDDWP-ARNYcidsLEQAIQLSPDNTYVKVLLAL-KLDAVHKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDR 260
Cdd:TIGR02917 374 LALGDFEkAAEY----LAKATELDPENAAARTQLGIsKLSQGDPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDK 449

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  261 AIQLLRKALEKLPNNAYVHYYMGCCYrskvhhmLNRREMvfSGDRKKLEELIQLAVNHLRKAEEikemleyscsfLADLY 340
Cdd:TIGR02917 450 ALAAAKKLEKKQPDNASLHNLLGAIY-------LGKGDL--AKAREAFEKALSIEPDFFPAAAN-----------LARID 509

                         250       260
                  ....*....|....*....|
gi 569006455  341 IIAKKYDEADYYFQKELSKD 360
Cdd:TIGR02917 510 IQEGNPDDAIQRFEKVLTID 529
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 151-357 1.98e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.39  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  151 KNQNERVKVCFQKALEKDPKNpeFTSGWAIANY-----RLDDwparnyCIDSLEQAIQLSPDNtyVKVLLAL-KLDAVHK 224
Cdd:TIGR02917 478 KGDLAKAREAFEKALSIEPDF--FPAAANLARIdiqegNPDD------AIQRFEKVLTIDPKN--LRAILALaGLYLRTG 547

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  225 NQAMAL--VEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNayVHYYMgccyrskvhhMLNRREMVfS 302
Cdd:TIGR02917 548 NEEEAVawLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDS--PEAWL----------MLGRAQLA-A 614

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 569006455  303 GDRKKleeliqlAVNHLRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKEL 357
Cdd:TIGR02917 615 GDLNK-------AVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRAL 662
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 151-239 2.96e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 151 KNQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLALKLDAV-HKNQAMA 229
Cdd:COG5010   67 LGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDE---AKEYYEKALALSPDNPNAYSNLAALLLSLgQDDEAKA 143

                         90
                 ....*....|
gi 569006455 230 LVEEALKKDP 239
Cdd:COG5010  144 ALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
195-274 3.77e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.46  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 195 IDSLEQAIQLSPDNTYVKVLLALKLDAVHKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPN 274
Cdd:COG3063   12 EEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
226-289 3.96e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.46  E-value: 3.96e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569006455 226 QAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQlLRKALEKLPNNAYVHYYMGCCYRSK 289
Cdd:COG3063   10 EAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLEL 72
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 64-200 4.83e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.75  E-value: 4.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  64 RGLNEAALQCLGEAEgfiqQQHPDQVEIrslvtWGNYAWVYYHMGQFSKAQAYLDKVKQVCKKFSSPYRienpaldceeG 143
Cdd:COG3914  125 LGRLEEALAALRRAL----ALNPDFAEA-----YLNLGEALRRLGRLEEAIAALRRALELDPDNAEALN----------N 185

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569006455 144 WARLKCTKNQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPARNYCIDSLEQ 200
Cdd:COG3914  186 LGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAA 242
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 213-360 5.34e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.41  E-value: 5.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 213 VLLALKLDAVHKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRSkvhh 292
Cdd:COG5010   25 EKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSR---- 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006455 293 mlnrremvfSGDRKKleeliqlAVNHLRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKELSKD 360
Cdd:COG5010  101 ---------SGDKDE-------AKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
HemYx COG3898
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type ...
 162-349 7.66e-05

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type protoporphyrinogen oxidase) [Function unknown];


Pssm-ID: 443105 [Multi-domain]  Cd Length: 468  Bit Score: 44.88  E-value: 7.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 162 QKALEKDPKNPEftSGWAIANYRLD--DWPARNYCIDSLEQAIQLSPDNtyVK----VLL---ALKLDAVHKNQAMALVE 232
Cdd:COG3898  176 EEALALAPKLPW--AQDALLELQAAagDWDGALATLDAALKAGLLDKDV--ARrrraVLLtarARELEEGDPDEARELAI 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 233 EALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPN----NAYVHyymgccyrskvhhmlnrremVFSGD---- 304
Cdd:COG3898  252 EALKLAPDLVPAAVLAARLLIAQGKLRKAAKVLEKAWRAQPHpdlaAAYAE--------------------LRPGDsald 311

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 569006455 305 R-KKLEELIQLAVNHLRKAeeikeMLeyscsfLADLYIIAKKYDEA 349
Cdd:COG3898  312 RlKRAETLAALNPDHPESR-----LA------LAEAALAAGDFGEA 346
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 161-279 9.13e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.07  E-value: 9.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  161 FQKALEKDPKNPEFTsGWAIAnyRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLALKLDAVHKNQAMALVEEALKKDPS 240
Cdd:TIGR02917 695 LQKQHPKAALGFELE-GDLYL--RQKDYPA---AIQAYRKALKRAPSSQNAIKLHRALLASGNTAEAVKTLEAWLKTHPN 768

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 569006455  241 AIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVH 279
Cdd:TIGR02917 769 DAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVL 807
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
257-360 9.91e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 9.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 257 DTDRAIQLLRKALEKLPNNAYVHYYMGCCYRskvhhmlnrremvfsgDRKKLEELIQlavnhLRKAEEIKEMLEYSCSFL 336
Cdd:COG3063    7 DLEEAEEYYEKALELDPDNADALNNLGLLLL----------------EQGRYDEAIA-----LEKALKLDPNNAEALLNL 65

                         90       100
                 ....*....|....*....|....
gi 569006455 337 ADLYIIAKKYDEADYYFQKELSKD 360
Cdd:COG3063   66 AELLLELGDYDEALAYLERALELD 89
TPR_19 pfam14559
Tetratricopeptide repeat;
225-279 1.45e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 39.87  E-value: 1.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 569006455  225 NQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVH 279
Cdd:pfam14559   5 AEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYA 59
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
151-243 2.58e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 2.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 151 KNQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWP-ARNYcidslEQAIQLSPDNTYVKVLLA-LKLDAVHKNQAM 228
Cdd:COG3063    5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDeAIAL-----EKALKLDPNNAEALLNLAeLLLELGDYDEAL 79

                         90
                 ....*....|....*
gi 569006455 229 ALVEEALKKDPSAID 243
Cdd:COG3063   80 AYLERALELDPSALR 94
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 195-273 2.71e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 195 IDSLEQAIQLSPDNTYVKVLLALKLDAV-HKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLP 273
Cdd:COG5010   74 LALLEQALQLDPNNPELYYNLALLYSRSgDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 198-288 2.77e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  198 LEQAIQLSPDNtyVKVL-----LALKLDAvhkNQAMALVEEALK---KDPSAIDTLlraARFYCKVYDTDRAIQLLRKAL 269
Cdd:TIGR02917 793 YQTVVKKAPDN--AVVLnnlawLYLELKD---PRALEYAERALKlapNIPAILDTL---GWLLVEKGEADRALPLLRKAV 864

                          90
                  ....*....|....*....
gi 569006455  270 EKLPNNAYVHYYMGCCYRS 288
Cdd:TIGR02917 865 NIAPEAAAIRYHLALALLA 883
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-208 2.93e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.95  E-value: 2.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  57 LAYVKHCRGLNEAALQCLGEAegfiQQQHPDQVEIrslvtWGNYAWVYYHMGQFSKAQAYLDKVKQVckkfsSPyriENP 136
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKA----LELDPDNPEA-----FALLGEILLQLGDLDEAIVLLHEALEL-----DP---DEP 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006455 137 ALDCEEGWARLKctKNQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPARnycIDSLEQAIQLSPDN 208
Cdd:COG4783   73 EARLNLGLALLK--AGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEA---IAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 196-432 1.05e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  196 DSLEQAIQLSPDNTYVK-----VLLALKLDAV----HKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLR 266
Cdd:TIGR02917 104 GKFQQVLDELPGKTLLDdegaaELLALRGLAYlglgQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALID 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  267 KALEKLPNNAYVHYYMGCCYRSK--------------------VHHMLNR-----REMVFSGDRKKLEELIQLAVNHLrK 321
Cdd:TIGR02917 184 EVLTADPGNVDALLLKGDLLLSLgnielalaayrkaialrpnnIAVLLALatiliEAGEFEEAEKHADALLKKAPNSP-L 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  322 AEEIKEMLEYScsfladlyiiAKKYDEADYYFQKELSKDlppgPKQLLHLRYGNFQFFQMKRQDKAIYHYMEGVKIKKKT 401
Cdd:TIGR02917 263 AHYLKALVDFQ----------KKNYEDARETLQDALKSA----PEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNS 328

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 569006455  402 IPQKKM------REKLQRIALRRLH----EDESDSEALHIL 432
Cdd:TIGR02917 329 HQARRLlasiqlRLGRVDEAIATLSpalgLDPDDPAALSLL 369
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 155-288 2.23e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 155 ERVKVCFQKALEKDPKNPEFTSgwAIANYRLddwparnyCIDSLEQAIQlspdntYVKVLLALKLDAVHKNQAMALVEEA 234
Cdd:cd24142  143 QRCEELITKALELDPTNPEALQ--TLASLRI--------SQQRPDEAKE------ALRRSLELWKDLKEEDEEEAEEDEA 206

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 569006455 235 LKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRS 288
Cdd:cd24142  207 EEEDVPSYEFRISLAKLLIELEMYEEALEVLEQLLDEDDEDVEVWYLLGWAYYL 260
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 226-340 2.39e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 226 QAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHY-YMG---------CCYRSKVHHMln 295
Cdd:cd24142   18 LALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEKYlYLGqlsggeealQYYEKGIEIL-- 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 569006455 296 rremvfsgdRKKLEELIQLAVNHLRKAEEIKEMLEYSCSFLADLY 340
Cdd:cd24142   96 ---------EEELQALQAASAEAEEEAEELKRKLSSALCALAEIY 131
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 152-276 3.50e-03

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 38.86  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  152 NQNERVKVCFQKALEKDPKNPEFTSGWAIANYRL--DDWPARNYcidslEQAIQLSPD-----NTYVKVLLALKldavHK 224
Cdd:TIGR02521  45 GDLEVAKENLDKALEHDPDDYLAYLALALYYQQLgeLEKAEDSF-----RRALTLNPNngdvlNNYGTFLCQQG----KY 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 569006455  225 NQAMALVEEALK--KDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNA 276
Cdd:TIGR02521 116 EQAMQQFEQAIEdpLYPQPARSLENAGLCALKAGDFDKAEKYLTRALQIDPQRP 169
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
161-277 5.42e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.36  E-value: 5.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 161 FQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYvkvllalkldaVHKNQAMALveEALKKDPS 240
Cdd:COG4785   96 FDQALELDPDLAEAYNNRGLAYLLLGDYDA---ALEDFDRALELDPDYAY-----------AYLNRGIAL--YYLGRYEL 159

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 569006455 241 AIDTLLRAARFYCKvyDTDRAIQLLRKALEKLPNNAY 277
Cdd:COG4785  160 AIADLEKALELDPN--DPERALWLYLAERKLDPEKAL 194
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
55-272 6.04e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.45  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455  55 NILAYVKHCRGLNEAALQCLGEAEgfiqQQHPDQVEIrslvtWGNYAWVYYHMGQFSKAQAYLDKVKQVCKKFSSPYRie 134
Cdd:COG0457   46 YNLGLAYLRLGRYEEALADYEQAL----ELDPDDAEA-----LNNLGLALQALGRYEEALEDYDKALELDPDDAEALY-- 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 135 npaldceeGWARLKCTKNQNERVKVCFQKALEKDPKNPEFTSGWAIANYRLDDWPARNYCIDSLEQAIQLSPDNTYVKVL 214
Cdd:COG0457  115 --------NLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEA 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569006455 215 LALKLDAVHKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKL 272
Cdd:COG0457  187 ALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 198-283 6.78e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 38.35  E-value: 6.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 198 LEQAIQLSPDNTYVKVLLALKLDAVHKnqAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPnNAY 277
Cdd:COG3071  216 LREALKRQWDPRLVRLYGRLQGGDPAK--QLKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRP-SAE 292


                 ....*.
gi 569006455 278 VHYYMG 283
Cdd:COG3071  293 AYAELA 298
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
161-270 6.80e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 37.97  E-value: 6.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006455 161 FQKALEKDPKNPEFTSGWAIANYRLDDWPArnyCIDSLEQAIQLSPDNTYVKVLLALKLDAVHKNQAMALVEEALKKDPS 240
Cdd:COG4785  130 FDRALELDPDYAYAYLNRGIALYYLGRYEL---AIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYL 206

                         90       100       110
                 ....*....|....*....|....*....|
gi 569006455 241 AIDtllraarfyckvyDTDRAIQLLRKALE 270
Cdd:COG4785  207 LQG-------------DTEEARELFKLALA 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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