NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|569011716|ref|XP_006528776|]
View 

toll-like receptor 7 isoform X1 [Mus musculus]

Protein Classification

toll/interleukin-1 receptor domain-containing protein( domain architecture ID 13321706)

toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Mus musculus toll-like receptor 12; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
487-789 9.46e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  487 SFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAF 566
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  567 EELQSLEVLDLSSNSHYFQAEGIThmlnftkklrlldKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWragdnry 646
Cdd:COG4886    93 GDLTNLTELDLSGNEELSNLTNLE-------------SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  647 lDFFKNLFNLEVLDISRNSLNSLPPEvFEGMPpNLKNLSLAKNGLKSFFwDRLQLLKHLEILDLSHNQLTKVPERLANCs 726
Cdd:COG4886   153 -EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANL- 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011716  727 KSLTTLILKHNQIRQLTKyfLEDALQLRYLDISSNKIqviqkTSFPENV-LNNLEMLVLHHNRF 789
Cdd:COG4886   228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 177-789 1.90e-18

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  177 IETLYLGQNcyyrnpcNVSYSIEKDAFLVMRNLKVLSLKDNNVT-AVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQ 255
Cdd:PLN00113   95 IQTINLSNN-------QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  256 VLDLSGNCpRCYNVPypctpcennsplqihdNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIee 335
Cdd:PLN00113  168 VLDLGGNV-LVGKIP----------------NSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI-- 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  336 AKFLHFLPNLVELDFSFNyelqvyHASITLPHSLSSLENLKilrvkgYVF---KELKNSSLSVLHKLPRLEVLDLGTNFI 412
Cdd:PLN00113  229 PYEIGGLTSLNHLDLVYN------NLTGPIPSSLGNLKNLQ------YLFlyqNKLSGPIPPSIFSLQKLISLDLSDNSL 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  413 --KIADLNIfkHFENLKLIDLSVNKISpseesrevGFCPNAQTSVDRHgpQVLEALhyfrydeyarSCRFKNKeppsfLP 490
Cdd:PLN00113  297 sgEIPELVI--QLQNLEILHLFSNNFT--------GKIPVALTSLPRL--QVLQLW----------SNKFSGE-----IP 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  491 LNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSeLWPLRELRYLDFSNNRLDLLYSTAFEELQ 570
Cdd:PLN00113  350 KNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLP 428

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  571 SLEVLDLSSNShyfqaegithmlnftkklrlldklmmndndistsasrtmesdslrileFRGNHLDVLWragdnryldff 650
Cdd:PLN00113  429 LVYFLDISNNN------------------------------------------------LQGRINSRKW----------- 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  651 kNLFNLEVLDISRNSLNSLPPEVFEGmpPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLT-KVPERLANCsKSL 729
Cdd:PLN00113  450 -DMPSLQMLSLARNKFFGGLPDSFGS--KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSC-KKL 525

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011716  730 TTLILKHNQIR-QLTKYFLEDALqLRYLDISSNKIQviqkTSFPENvLNNLEMLV---LHHNRF 789
Cdd:PLN00113  526 VSLDLSHNQLSgQIPASFSEMPV-LSQLDLSQNQLS----GEIPKN-LGNVESLVqvnISHNHL 583
TIR smart00255
Toll - interleukin 1 - resistance;
894-1039 1.06e-15

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 75.05  E-value: 1.06e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716    894 CYDAFIVYdtknsAVTEWVLQELVAKLEDpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKM 973
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011716    974 AFYLSHQRLLDEKVDVIILIFLE--KPLQKSKFLQLRKRLcRSSVLEWPANPQAHpyFWqclKNALTT 1039
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEviPSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FW---KKALYA 136
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
35-246 8.56e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 8.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   35 KTLPCEVKVNIPEAHVivdcTDKHLTEIPEGIPTNTTNLTLTINHIPSIsPDsfRRLNHLEEIDLRCNCVPVLlgskanv 114
Cdd:PRK15370  212 KSLPENLQGNIKTLYA----NSNQLTSIPATLPDTIQEMELSINRITEL-PE--RLPSALQSLDLFHNKISCL------- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  115 ctkrlqirPGSFSglSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANnifSITKENLTELVNIETLYLGQNCYYRNPCNV 194
Cdd:PRK15370  278 --------PENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPPGLKTLEAGENALTSLPASL 344

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569011716  195 SYSiekdaflvmrnLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQEN 246
Cdd:PRK15370  345 PPE-----------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 757-841 7.35e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.47  E-value: 7.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   757 DISSNKIQVIQKTSFpeNVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTI--PYLAtdvTCVGPGAHKGQSVISLDL 834
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 569011716   835 YTCELDL 841
Cdd:TIGR00864   76 LDSGCDE 82
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
487-789 9.46e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  487 SFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAF 566
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  567 EELQSLEVLDLSSNSHYFQAEGIThmlnftkklrlldKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWragdnry 646
Cdd:COG4886    93 GDLTNLTELDLSGNEELSNLTNLE-------------SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  647 lDFFKNLFNLEVLDISRNSLNSLPPEvFEGMPpNLKNLSLAKNGLKSFFwDRLQLLKHLEILDLSHNQLTKVPERLANCs 726
Cdd:COG4886   153 -EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANL- 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011716  727 KSLTTLILKHNQIRQLTKyfLEDALQLRYLDISSNKIqviqkTSFPENV-LNNLEMLVLHHNRF 789
Cdd:COG4886   228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 177-789 1.90e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  177 IETLYLGQNcyyrnpcNVSYSIEKDAFLVMRNLKVLSLKDNNVT-AVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQ 255
Cdd:PLN00113   95 IQTINLSNN-------QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  256 VLDLSGNCpRCYNVPypctpcennsplqihdNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIee 335
Cdd:PLN00113  168 VLDLGGNV-LVGKIP----------------NSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI-- 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  336 AKFLHFLPNLVELDFSFNyelqvyHASITLPHSLSSLENLKilrvkgYVF---KELKNSSLSVLHKLPRLEVLDLGTNFI 412
Cdd:PLN00113  229 PYEIGGLTSLNHLDLVYN------NLTGPIPSSLGNLKNLQ------YLFlyqNKLSGPIPPSIFSLQKLISLDLSDNSL 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  413 --KIADLNIfkHFENLKLIDLSVNKISpseesrevGFCPNAQTSVDRHgpQVLEALhyfrydeyarSCRFKNKeppsfLP 490
Cdd:PLN00113  297 sgEIPELVI--QLQNLEILHLFSNNFT--------GKIPVALTSLPRL--QVLQLW----------SNKFSGE-----IP 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  491 LNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSeLWPLRELRYLDFSNNRLDLLYSTAFEELQ 570
Cdd:PLN00113  350 KNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLP 428

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  571 SLEVLDLSSNShyfqaegithmlnftkklrlldklmmndndistsasrtmesdslrileFRGNHLDVLWragdnryldff 650
Cdd:PLN00113  429 LVYFLDISNNN------------------------------------------------LQGRINSRKW----------- 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  651 kNLFNLEVLDISRNSLNSLPPEVFEGmpPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLT-KVPERLANCsKSL 729
Cdd:PLN00113  450 -DMPSLQMLSLARNKFFGGLPDSFGS--KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSC-KKL 525

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011716  730 TTLILKHNQIR-QLTKYFLEDALqLRYLDISSNKIQviqkTSFPENvLNNLEMLV---LHHNRF 789
Cdd:PLN00113  526 VSLDLSHNQLSgQIPASFSEMPV-LSQLDLSQNQLS----GEIPKN-LGNVESLVqvnISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
127-437 4.35e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 4.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  127 SGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVM 206
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  207 RNLKVLSLKDNNVTAVPTtlppNLLELYLYNNIIKKIqENDFNNLNELQVLDLSGNcprcynvpypctpcennsplQIHD 286
Cdd:COG4886    96 TNLTELDLSGNEELSNLT----NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN--------------------QLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  287 --NAFNSLTELKVLRLHSNSLQHVPPtWFKNMRNLQELDLSQNYLAreiEEAKFLHFLPNLVELDFSFNyELQvyhasiT 364
Cdd:COG4886   151 lpEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQIT---DLPEPLGNLTNLEELDLSGN-QLT------D 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011716  365 LPHSLSSLENLKILRVKGyvfkelkN--SSLSVLHKLPRLEVLDLGTNfiKIADLNIFKHFENLKLIDLSVNKIS 437
Cdd:COG4886   220 LPEPLANLTNLETLDLSN-------NqlTDLPELGNLTNLEELDLSNN--QLTDLPPLANLTNLKTLDLSNNQLT 285
TIR smart00255
Toll - interleukin 1 - resistance;
894-1039 1.06e-15

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 75.05  E-value: 1.06e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716    894 CYDAFIVYdtknsAVTEWVLQELVAKLEDpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKM 973
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011716    974 AFYLSHQRLLDEKVDVIILIFLE--KPLQKSKFLQLRKRLcRSSVLEWPANPQAHpyFWqclKNALTT 1039
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEviPSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FW---KKALYA 136
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
659-791 1.67e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.02  E-value: 1.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  659 LDISRNSLNSLPpevfEGMPPNLKNLSLAKNGLKSFfwdRLQLLKHLEILDLSHNQLTKVPERLANcskSLTTLILKHNQ 738
Cdd:PRK15370  204 LILDNNELKSLP----ENLQGNIKTLYANSNQLTSI---PATLPDTIQEMELSINRITELPERLPS---ALQSLDLFHNK 273

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011716  739 IRQLTKYFLEdalQLRYLDISSNKIQVIQK----------------TSFPENVLNNLEMLVLHHNRFLC 791
Cdd:PRK15370  274 ISCLPENLPE---ELRYLSVYDNSIRTLPAhlpsgithlnvqsnslTALPETLPPGLKTLEAGENALTS 339
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 201-353 1.90e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  201 DAFLVMRNLKVLSLKDNNVTAVPTTLP-PNLLELYLYNNIIKKIQenDFNNLNELQVLDLSGNC-------PRCYN---- 268
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIENLEFlTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRisvveglENLTNleel 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  269 -VPYPCTPCENnsPLQIHDNAFNSLTE-LKVLRLHSNSLQHVppTWFKNMRNLQELDLSQNYLaREIEEAK-FLHFLPNL 345
Cdd:cd21340    96 hIENQRLPPGE--KLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI-SDLEELLdLLSSWPSL 170


                  ....*...
gi 569011716  346 VELDFSFN 353
Cdd:cd21340   171 RELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
35-246 8.56e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 8.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   35 KTLPCEVKVNIPEAHVivdcTDKHLTEIPEGIPTNTTNLTLTINHIPSIsPDsfRRLNHLEEIDLRCNCVPVLlgskanv 114
Cdd:PRK15370  212 KSLPENLQGNIKTLYA----NSNQLTSIPATLPDTIQEMELSINRITEL-PE--RLPSALQSLDLFHNKISCL------- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  115 ctkrlqirPGSFSglSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANnifSITKENLTELVNIETLYLGQNCYYRNPCNV 194
Cdd:PRK15370  278 --------PENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPPGLKTLEAGENALTSLPASL 344

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569011716  195 SYSiekdaflvmrnLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQEN 246
Cdd:PRK15370  345 PPE-----------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 895-1021 9.40e-09

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 55.83  E-value: 9.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   895 YDAFIvyDTKNSAVTEWVLQELVAKLedpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAktESFKMA 974
Cdd:pfam01582    1 YDVFL--SFRGSDTREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYA--SSGWCL 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 569011716   975 FYLSH-QRLLDEKVDVIILIFLEK-----PLQKSKFLQLRKRLCR----SSVLEWPA 1021
Cdd:pfam01582   74 DELVKiLECALDLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWRG 130
LRR_8 pfam13855
Leucine rich repeat;
293-353 1.12e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.12e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011716   293 TELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLaREIEEAKFLHfLPNLVELDFSFN 353
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSG-LPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
500-558 3.92e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.92e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 569011716   500 QTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIgQTLNGSELWPLRELRYLDFSNNRL 558
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 643-787 2.24e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  643 DNR--YLDFFKNLFNLEVLDISRNSLNSLppEVFEGMPpNLKNLSLAKN------GLksffwdrlQLLKHLEILDLSHNQ 714
Cdd:cd21340    33 DNKitKIENLEFLTNLTHLYLQNNQIEKI--ENLENLV-NLKKLYLGGNrisvveGL--------ENLTNLEELHIENQR 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011716  715 L------TKVPERLANCSKSLTTLILKHNQIRQLTkyFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHN 787
Cdd:cd21340   102 LppgeklTFDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
78-142 2.58e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.58e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011716    78 NHIPSISPDSFRRLNHLEEIDLRCNCVPVllgskanvctkrlqIRPGSFSGLSDLKALYLDGNQL 142
Cdd:pfam13855   11 NRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 757-841 7.35e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.47  E-value: 7.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   757 DISSNKIQVIQKTSFpeNVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTI--PYLAtdvTCVGPGAHKGQSVISLDL 834
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 569011716   835 YTCELDL 841
Cdd:TIGR00864   76 LDSGCDE 82
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-262 2.83e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   78 NHIPSIsPDSFRRLNHLEEIDLRCNCVPVLlgskanvctkrlqirPGSFSGLSDLKALYLDGNQLLEIPqdlpsslhlls 157
Cdd:COG4886   169 NQLTDL-PEELGNLTNLKELDLSNNQITDL---------------PEPLGNLTNLEELDLSGNQLTDLP----------- 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  158 leannifsitkENLTELVNIETLYLGQNcyyrnpcNVSysiEKDAFLVMRNLKVLSLKDNNVTAVPTTLP-PNLLELYLY 236
Cdd:COG4886   222 -----------EPLANLTNLETLDLSNN-------QLT---DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLS 280

                         170       180
                  ....*....|....*....|....*.
gi 569011716  237 NNIIKKIQENDFNNLNELQVLDLSGN 262
Cdd:COG4886   281 NNQLTDLKLKELELLLGLNSLLLLLL 306
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
487-789 9.46e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  487 SFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAF 566
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  567 EELQSLEVLDLSSNSHYFQAEGIThmlnftkklrlldKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWragdnry 646
Cdd:COG4886    93 GDLTNLTELDLSGNEELSNLTNLE-------------SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  647 lDFFKNLFNLEVLDISRNSLNSLPPEvFEGMPpNLKNLSLAKNGLKSFFwDRLQLLKHLEILDLSHNQLTKVPERLANCs 726
Cdd:COG4886   153 -EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANL- 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011716  727 KSLTTLILKHNQIRQLTKyfLEDALQLRYLDISSNKIqviqkTSFPENV-LNNLEMLVLHHNRF 789
Cdd:COG4886   228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 177-789 1.90e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  177 IETLYLGQNcyyrnpcNVSYSIEKDAFLVMRNLKVLSLKDNNVT-AVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQ 255
Cdd:PLN00113   95 IQTINLSNN-------QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  256 VLDLSGNCpRCYNVPypctpcennsplqihdNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIee 335
Cdd:PLN00113  168 VLDLGGNV-LVGKIP----------------NSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI-- 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  336 AKFLHFLPNLVELDFSFNyelqvyHASITLPHSLSSLENLKilrvkgYVF---KELKNSSLSVLHKLPRLEVLDLGTNFI 412
Cdd:PLN00113  229 PYEIGGLTSLNHLDLVYN------NLTGPIPSSLGNLKNLQ------YLFlyqNKLSGPIPPSIFSLQKLISLDLSDNSL 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  413 --KIADLNIfkHFENLKLIDLSVNKISpseesrevGFCPNAQTSVDRHgpQVLEALhyfrydeyarSCRFKNKeppsfLP 490
Cdd:PLN00113  297 sgEIPELVI--QLQNLEILHLFSNNFT--------GKIPVALTSLPRL--QVLQLW----------SNKFSGE-----IP 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  491 LNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSeLWPLRELRYLDFSNNRLDLLYSTAFEELQ 570
Cdd:PLN00113  350 KNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLP 428

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  571 SLEVLDLSSNShyfqaegithmlnftkklrlldklmmndndistsasrtmesdslrileFRGNHLDVLWragdnryldff 650
Cdd:PLN00113  429 LVYFLDISNNN------------------------------------------------LQGRINSRKW----------- 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  651 kNLFNLEVLDISRNSLNSLPPEVFEGmpPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLT-KVPERLANCsKSL 729
Cdd:PLN00113  450 -DMPSLQMLSLARNKFFGGLPDSFGS--KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSC-KKL 525

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011716  730 TTLILKHNQIR-QLTKYFLEDALqLRYLDISSNKIQviqkTSFPENvLNNLEMLV---LHHNRF 789
Cdd:PLN00113  526 VSLDLSHNQLSgQIPASFSEMPV-LSQLDLSQNQLS----GEIPKN-LGNVESLVqvnISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
127-437 4.35e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 4.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  127 SGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVM 206
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  207 RNLKVLSLKDNNVTAVPTtlppNLLELYLYNNIIKKIqENDFNNLNELQVLDLSGNcprcynvpypctpcennsplQIHD 286
Cdd:COG4886    96 TNLTELDLSGNEELSNLT----NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN--------------------QLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  287 --NAFNSLTELKVLRLHSNSLQHVPPtWFKNMRNLQELDLSQNYLAreiEEAKFLHFLPNLVELDFSFNyELQvyhasiT 364
Cdd:COG4886   151 lpEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQIT---DLPEPLGNLTNLEELDLSGN-QLT------D 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011716  365 LPHSLSSLENLKILRVKGyvfkelkN--SSLSVLHKLPRLEVLDLGTNfiKIADLNIFKHFENLKLIDLSVNKIS 437
Cdd:COG4886   220 LPEPLANLTNLETLDLSN-------NqlTDLPELGNLTNLEELDLSNN--QLTDLPPLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
500-845 2.31e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  500 QTLDLSRNNiffikpsDFQHLSFLKCLNLSGNTIGQTlnGSELWPLRELRYLDFSNNRLDLLySTAFEELQSLEVLDLSS 579
Cdd:COG4886    99 TELDLSGNE-------ELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSN 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  580 NshyfqaeGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLwragdnryLDFFKNLFNLEVL 659
Cdd:COG4886   169 N-------QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL--------PEPLANLTNLETL 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  660 DISRNSLNSLPpeVFEGMPpNLKNLSLAKNGLKSFfwDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQI 739
Cdd:COG4886   234 DLSNNQLTDLP--ELGNLT-NLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  740 RQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCV 819
Cdd:COG4886   309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                         330       340
                  ....*....|....*....|....*.
gi 569011716  820 GPGAHKGQSVISLDLYTCELDLTNLI 845
Cdd:COG4886   389 LLLLLLTTTAGVLLLTLALLDAVNTE 414
TIR smart00255
Toll - interleukin 1 - resistance;
894-1039 1.06e-15

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 75.05  E-value: 1.06e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716    894 CYDAFIVYdtknsAVTEWVLQELVAKLEDpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKM 973
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011716    974 AFYLSHQRLLDEKVDVIILIFLE--KPLQKSKFLQLRKRLcRSSVLEWPANPQAHpyFWqclKNALTT 1039
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEviPSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FW---KKALYA 136
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-435 1.33e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   84 SPDSFRRLNHLEEIDLRCNCVPVLlgskanvctkrlqirPGSFSGLSDLKALYLDGNQLLEIPqdlpsslhllsleanni 163
Cdd:COG4886   105 GNEELSNLTNLESLDLSGNQLTDL---------------PEELANLTNLKELDLSNNQLTDLP----------------- 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  164 fsitkENLTELVNIETLYLGQNcyyrnpcnvsySIEK--DAFLVMRNLKVLSLKDNNVTAVPTTL--PPNLLELYLYNNI 239
Cdd:COG4886   153 -----EPLGNLTNLKSLDLSNN-----------QLTDlpEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQ 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  240 IKKIqENDFNNLNELQVLDLSGNcprcynvpypctpcennsplQIHD-NAFNSLTELKVLRLHSNSLQHVPPTwfKNMRN 318
Cdd:COG4886   217 LTDL-PEPLANLTNLETLDLSNN--------------------QLTDlPELGNLTNLEELDLSNNQLTDLPPL--ANLTN 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  319 LQELDLSQNYLAR-EIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLH 397
Cdd:COG4886   274 LKTLDLSNNQLTDlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 569011716  398 KLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNK 435
Cdd:COG4886   354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
573-789 2.54e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 2.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  573 EVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLD---- 648
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSllll 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  649 ---FFKNLFNLEVLDISRNS-LNSLPpevfegmppNLKNLSLAKNGLKSFFWDrLQLLKHLEILDLSHNQLTKVPERLAN 724
Cdd:COG4886    88 gltDLGDLTNLTELDLSGNEeLSNLT---------NLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGN 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569011716  725 CsKSLTTLILKHNQIRQLTKyFLEDALQLRYLDISSNKIqviqkTSFPENV--LNNLEMLVLHHNRF 789
Cdd:COG4886   158 L-TNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI-----TDLPEPLgnLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
159-437 3.85e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 3.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  159 EANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNN 238
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  239 IIKKIQENDFNNLNELQVLDLSGNCPRcynvpypcTPCENNSPLQIHDN-------AFNSLTELKVLRLHSNSLQHVPPt 311
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTELDLSGNEEL--------SNLTNLESLDLSGNqltdlpeELANLTNLKELDLSNNQLTDLPE- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  312 WFKNMRNLQELDLSQNYLaREIEEAkfLHFLPNLVELDFSFNyelqvyhaSIT-LPHSLSSLENLKILRVKGYVFKELKN 390
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQL-TDLPEE--LGNLTNLKELDLSNN--------QITdLPEPLGNLTNLEELDLSGNQLTDLPE 222

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 569011716  391 SslsvLHKLPRLEVLDLGTNfiKIADLNIFKHFENLKLIDLSVNKIS 437
Cdd:COG4886   223 P----LANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLT 263
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
659-791 1.67e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.02  E-value: 1.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  659 LDISRNSLNSLPpevfEGMPPNLKNLSLAKNGLKSFfwdRLQLLKHLEILDLSHNQLTKVPERLANcskSLTTLILKHNQ 738
Cdd:PRK15370  204 LILDNNELKSLP----ENLQGNIKTLYANSNQLTSI---PATLPDTIQEMELSINRITELPERLPS---ALQSLDLFHNK 273

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011716  739 IRQLTKYFLEdalQLRYLDISSNKIQVIQK----------------TSFPENVLNNLEMLVLHHNRFLC 791
Cdd:PRK15370  274 ISCLPENLPE---ELRYLSVYDNSIRTLPAhlpsgithlnvqsnslTALPETLPPGLKTLEAGENALTS 339
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 201-353 1.90e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  201 DAFLVMRNLKVLSLKDNNVTAVPTTLP-PNLLELYLYNNIIKKIQenDFNNLNELQVLDLSGNC-------PRCYN---- 268
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIENLEFlTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRisvveglENLTNleel 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  269 -VPYPCTPCENnsPLQIHDNAFNSLTE-LKVLRLHSNSLQHVppTWFKNMRNLQELDLSQNYLaREIEEAK-FLHFLPNL 345
Cdd:cd21340    96 hIENQRLPPGE--KLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI-SDLEELLdLLSSWPSL 170


                  ....*...
gi 569011716  346 VELDFSFN 353
Cdd:cd21340   171 RELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
35-246 8.56e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 8.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   35 KTLPCEVKVNIPEAHVivdcTDKHLTEIPEGIPTNTTNLTLTINHIPSIsPDsfRRLNHLEEIDLRCNCVPVLlgskanv 114
Cdd:PRK15370  212 KSLPENLQGNIKTLYA----NSNQLTSIPATLPDTIQEMELSINRITEL-PE--RLPSALQSLDLFHNKISCL------- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  115 ctkrlqirPGSFSglSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANnifSITKENLTELVNIETLYLGQNCYYRNPCNV 194
Cdd:PRK15370  278 --------PENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPPGLKTLEAGENALTSLPASL 344

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569011716  195 SYSiekdaflvmrnLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQEN 246
Cdd:PRK15370  345 PPE-----------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
107-372 9.01e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 9.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  107 LLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPqdlpsslhllsleannifsitkENLTelVNIETLYLGQNC 186
Cdd:PRK15370  176 LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLP----------------------ENLQ--GNIKTLYANSNQ 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  187 YYRNPCNVSYSIEKDAFLVMR----------NLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQV 256
Cdd:PRK15370  232 LTSIPATLPDTIQEMELSINRitelperlpsALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNV 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  257 LDLSGNCprcynvpYPCTPCENNSPLQIHDNAFNSL-----TELKVLRLHSNSL----QHVPPTwfknmrnLQELDLSQN 327
Cdd:PRK15370  312 QSNSLTA-------LPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNQItvlpETLPPT-------ITTLDVSRN 377

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 569011716  328 YLAreieeakflhflpNLVE-LDFSFNYELQVYHASITLPHSLSSL 372
Cdd:PRK15370  378 ALT-------------NLPEnLPAALQIMQASRNNLVRLPESLPHF 410
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 895-1021 9.40e-09

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 55.83  E-value: 9.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   895 YDAFIvyDTKNSAVTEWVLQELVAKLedpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAktESFKMA 974
Cdd:pfam01582    1 YDVFL--SFRGSDTREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYA--SSGWCL 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 569011716   975 FYLSH-QRLLDEKVDVIILIFLEK-----PLQKSKFLQLRKRLCR----SSVLEWPA 1021
Cdd:pfam01582   74 DELVKiLECALDLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWRG 130
LRR_8 pfam13855
Leucine rich repeat;
293-353 1.12e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.12e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011716   293 TELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLaREIEEAKFLHfLPNLVELDFSFN 353
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSG-LPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 206-437 1.71e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  206 MRNLKVLSLKDNNVTAVPT-TLPPNLLELYLYNNIIKKIQenDFNNLNELQVLDLSGNCprcynvpypCTPCENnsplqi 284
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQ---------IEKIEN------ 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  285 hdnaFNSLTELKVLRLHSNSLQHVppTWFKNMRNLQELDLS-QNylareieeakflhfLPNLVELDFSfnyelqvyhasi 363
Cdd:cd21340    64 ----LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIEnQR--------------LPPGEKLTFD------------ 111

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011716  364 tlPHSLSSL-ENLKILRVKGyvfkelkN--SSLSVLHKLPRLEVLDLGTNFIK-IADL-NIFKHFENLKLIDLSVNKIS 437
Cdd:cd21340   112 --PRSLAALsNSLRVLNISG-------NniDSLEPLAPLRNLEQLDASNNQISdLEELlDLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 498-790 1.77e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.71  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  498 YGQTLDLSRNNIFFIKPSD-FQHLSFLKCLNLSGNTI-GQTLNGS--------------------ELWPLRELRYLDFSN 555
Cdd:PLN00113   94 YIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFtGSIPRGSipnletldlsnnmlsgeipnDIGSFSSLKVLDLGG 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  556 NRLDLLYSTAFEELQSLEVLDLSSNShyfQAEGITHMLNftkKLRLLDKLMMNDNDISTSASRTM-ESDSLrilefrgNH 634
Cdd:PLN00113  174 NVLVGKIPNSLTNLTSLEFLTLASNQ---LVGQIPRELG---QMKSLKWIYLGYNNLSGEIPYEIgGLTSL-------NH 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  635 LDVLWR------------AGDNRYLDFFKN------------LFNLEVLDISRNSLNSLPPEVFEGMPpNLKNLSLAKN- 689
Cdd:PLN00113  241 LDLVYNnltgpipsslgnLKNLQYLFLYQNklsgpippsifsLQKLISLDLSDNSLSGEIPELVIQLQ-NLEILHLFSNn 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  690 -------GLKSFfwDRLQLL----------------KH--LEILDLSHNQLT-KVPERLANcSKSLTTLILKHNQI---- 739
Cdd:PLN00113  320 ftgkipvALTSL--PRLQVLqlwsnkfsgeipknlgKHnnLTVLDLSTNNLTgEIPEGLCS-SGNLFKLILFSNSLegei 396

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011716  740 -------RQLTKYFLED------------ALQLRY-LDISSNKIQVIQKTSFPEnvLNNLEMLVLHHNRFL 790
Cdd:PLN00113  397 pkslgacRSLRRVRLQDnsfsgelpseftKLPLVYfLDISNNNLQGRINSRKWD--MPSLQMLSLARNKFF 465
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
548-743 2.69e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 2.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  548 LRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNS---HYfqAEGITHMLNFTKKLRLL-DKLMMNdndistsasrtmesd 623
Cdd:PRK15370  264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTlpaHL--PSGITHLNVQSNSLTALpETLPPG--------------- 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  624 sLRILEfrgnhldvlwrAGDNRYLDFFKNL-FNLEVLDISRNSLNSLPpevfEGMPPNLKNLSLAKNGLKSFfwdRLQLL 702
Cdd:PRK15370  327 -LKTLE-----------AGENALTSLPASLpPELQVLDVSKNQITVLP----ETLPPTITTLDVSRNALTNL---PENLP 387

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 569011716  703 KHLEILDLSHNQLTKVPERLANC---SKSLTTLILKHNQIRQLT 743
Cdd:PRK15370  388 AALQIMQASRNNLVRLPESLPHFrgeGPQPTRIIVEYNPFSERT 431
LRR_8 pfam13855
Leucine rich repeat;
500-558 3.92e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.92e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 569011716   500 QTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIgQTLNGSELWPLRELRYLDFSNNRL 558
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
527-783 4.92e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 4.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  527 NLSGNTIGQTLNGSELWPLRE-----LRYLDFSNNRLDLLYstafEELQS-LEVLDLSSNSHYFQAEgithmlNFTKKLR 600
Cdd:PRK15370  217 NLQGNIKTLYANSNQLTSIPAtlpdtIQEMELSINRITELP----ERLPSaLQSLDLFHNKISCLPE------NLPEELR 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  601 LLDklmMNDNDISTSASRTMESDSlrilefrgnHLDVLwragdNRYLDFFKNLF--NLEVLDISRNSLNSLPpevfEGMP 678
Cdd:PRK15370  287 YLS---VYDNSIRTLPAHLPSGIT---------HLNVQ-----SNSLTALPETLppGLKTLEAGENALTSLP----ASLP 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  679 PNLKNLSLAKNglksffwdRLQLLKH-----LEILDLSHNQLTKVPErlaNCSKSLTTLILKHNQIRQLTK---YFLEDA 750
Cdd:PRK15370  346 PELQVLDVSKN--------QITVLPEtlpptITTLDVSRNALTNLPE---NLPAALQIMQASRNNLVRLPEslpHFRGEG 414

                         250       260       270
                  ....*....|....*....|....*....|...
gi 569011716  751 LQlryldisSNKIqVIQKTSFPENVLNNLEMLV 783
Cdd:PRK15370  415 PQ-------PTRI-IVEYNPFSERTIQNMQRLM 439
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 501-789 8.76e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 8.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  501 TLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFeeLQSLEVLDLSSN 580
Cdd:PLN00113   73 SIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNN 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  581 ShyfqaegithmlnFTKKLrlldklmmnDNDISTSAsrtmesdSLRILEFRGNHLdvlwragDNRYLDFFKNLFNLEVLD 660
Cdd:PLN00113  151 M-------------LSGEI---------PNDIGSFS-------SLKVLDLGGNVL-------VGKIPNSLTNLTSLEFLT 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  661 ISRNSL-NSLPPEVfeGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLT-KVPERLANCSKsLTTLILKHNQ 738
Cdd:PLN00113  195 LASNQLvGQIPREL--GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKN-LQYLFLYQNK 271

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569011716  739 IRQLTKYFLEDALQLRYLDISSNKIQviqkTSFPENV--LNNLEMLVLHHNRF 789
Cdd:PLN00113  272 LSGPIPPSIFSLQKLISLDLSDNSLS----GEIPELViqLQNLEILHLFSNNF 320
LRR_8 pfam13855
Leucine rich repeat;
278-329 1.31e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.31e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 569011716   278 NNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYL 329
Cdd:pfam13855   10 NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 643-787 2.24e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  643 DNR--YLDFFKNLFNLEVLDISRNSLNSLppEVFEGMPpNLKNLSLAKN------GLksffwdrlQLLKHLEILDLSHNQ 714
Cdd:cd21340    33 DNKitKIENLEFLTNLTHLYLQNNQIEKI--ENLENLV-NLKKLYLGGNrisvveGL--------ENLTNLEELHIENQR 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011716  715 L------TKVPERLANCSKSLTTLILKHNQIRQLTkyFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHN 787
Cdd:cd21340   102 LppgeklTFDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
679-739 7.71e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 7.71e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011716   679 PNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQI 739
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
78-142 2.58e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.58e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011716    78 NHIPSISPDSFRRLNHLEEIDLRCNCVPVllgskanvctkrlqIRPGSFSGLSDLKALYLDGNQL 142
Cdd:pfam13855   11 NRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 898-996 4.28e-06

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 46.92  E-value: 4.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   898 FIVYDTKNSAVTEWVLQELvakledpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYL 977
Cdd:pfam13676    2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74

                           90
                   ....*....|....*....
gi 569011716   978 SHQRLLDEKvdVIILIFLE 996
Cdd:pfam13676   75 ALADPEGRK--RLIPVRLE 91
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
608-789 6.32e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 6.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  608 NDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLSLA 687
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  688 KNGLKSFFWDRLQLLKHLEIL-----------------DLSHNQLTKVPERLANCsKSLTTLILKHNQIRQLTKyFLEDA 750
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELdlsgneelsnltnleslDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLPE-PLGNL 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 569011716  751 LQLRYLDISSNKIqviqkTSFPENV--LNNLEMLVLHHNRF 789
Cdd:COG4886   159 TNLKSLDLSNNQL-----TDLPEELgnLTNLKELDLSNNQI 194
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 757-841 7.35e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.47  E-value: 7.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   757 DISSNKIQVIQKTSFpeNVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTI--PYLAtdvTCVGPGAHKGQSVISLDL 834
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 569011716   835 YTCELDL 841
Cdd:TIGR00864   76 LDSGCDE 82
LRR_8 pfam13855
Leucine rich repeat;
207-262 8.96e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 8.96e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 569011716   207 RNLKVLSLKDNNVTAVPTTL---PPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGN 262
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 456-723 1.70e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  456 DRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYG---QTLDLSRNNIFFIKP---SDFQHLSFLKCLNLS 529
Cdd:cd00116    37 EEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQGLTKGcglQELDLSDNALGPDGCgvlESLLRSSSLQELKLN 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  530 ----GNTIGQTLNGSELWPLRELRYLDFSNNRL------DLlySTAFEELQSLEVLDLSSNShyFQAEGITHMLNFTKKL 599
Cdd:cd00116   117 nnglGDRGLRLLAKGLKDLPPALEKLVLGRNRLegasceAL--AKALRANRDLKELNLANNG--IGDAGIRALAEGLKAN 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  600 RLLDKLMMNDNDIStsasrtmesdslrilefrgnhldvlwRAGDNRYLDFFKNLFNLEVLDISRNSLNSLP-PEVFEGMP 678
Cdd:cd00116   193 CNLEVLDLNNNGLT--------------------------DEGASALAETLASLKSLEVLNLGDNNLTDAGaAALASALL 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569011716  679 ---PNLKNLSLAKNGLK-SFFWDRLQLLKH---LEILDLSHNQLTKVPERLA 723
Cdd:cd00116   247 spnISLLTLSLSCNDITdDGAKDLAEVLAEkesLLELDLRGNKFGEEGAQLL 298
LRR_8 pfam13855
Leucine rich repeat;
728-789 1.75e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.75e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011716   728 SLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPEnvLNNLEMLVLHHNRF 789
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG--LPSLRYLDLSGNRL 61
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 402-431 2.10e-05

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 42.33  E-value: 2.10e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 569011716   402 LEVLDLGTNFIKIADLNIFKHFENLKLIDL 431
Cdd:pfam18837    1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-262 2.83e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   78 NHIPSIsPDSFRRLNHLEEIDLRCNCVPVLlgskanvctkrlqirPGSFSGLSDLKALYLDGNQLLEIPqdlpsslhlls 157
Cdd:COG4886   169 NQLTDL-PEELGNLTNLKELDLSNNQITDL---------------PEPLGNLTNLEELDLSGNQLTDLP----------- 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  158 leannifsitkENLTELVNIETLYLGQNcyyrnpcNVSysiEKDAFLVMRNLKVLSLKDNNVTAVPTTLP-PNLLELYLY 236
Cdd:COG4886   222 -----------EPLANLTNLETLDLSNN-------QLT---DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLS 280

                         170       180
                  ....*....|....*....|....*.
gi 569011716  237 NNIIKKIQENDFNNLNELQVLDLSGN 262
Cdd:COG4886   281 NNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
624-691 3.27e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 3.27e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011716   624 SLRILEFRGNHLDVLwraGDnrylDFFKNLFNLEVLDISRNSLNSLPPEVFEGMpPNLKNLSLAKNGL 691
Cdd:pfam13855    2 NLRSLDLSNNRLTSL---DD----GAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 523-763 4.58e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  523 LKCLNLSGNTIGQT---LNGSELWPLRELRYLDFSNNRL-DLLYST-----AFEELQSLEVLDLSSNShyFQAEGITHML 593
Cdd:cd00116    25 LQVLRLEGNTLGEEaakALASALRPQPSLKELCLSLNETgRIPRGLqsllqGLTKGCGLQELDLSDNA--LGPDGCGVLE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  594 NFTKKLRLlDKLMMNDNDISTSASRTMeSDSLRILEFRGNHLdVLWR-----AGDNRYLDFFKNLFNLEVLDISRNSLN- 667
Cdd:cd00116   103 SLLRSSSL-QELKLNNNGLGDRGLRLL-AKGLKDLPPALEKL-VLGRnrlegASCEALAKALRANRDLKELNLANNGIGd 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  668 SLPPEVFEGMP--PNLKNLSLAKNGLK----SFFWDRLQLLKHLEILDLSHNQLTKVP-----ERLANCSKSLTTLILKH 736
Cdd:cd00116   180 AGIRALAEGLKanCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSC 259

                         250       260       270
                  ....*....|....*....|....*....|.
gi 569011716  737 NQIRQLT----KYFLEDALQLRYLDISSNKI 763
Cdd:cd00116   260 NDITDDGakdlAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
704-763 5.68e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 5.68e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   704 HLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKI 763
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 531-763 1.55e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  531 NTIGQTLNGSELWPLRELRYLDFSNN-----RLDLLYSTAFEELQSLEVLDLSSNshYFQAEGITHMLNFTKKLRLLDKL 605
Cdd:COG5238   136 ALPRRINLIQVLKDPLGGNAVHLLGLaarlgLLAAISMAKALQNNSVETVYLGCN--QIGDEGIEELAEALTQNTTVTTL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  606 MMNDNDISTSASRTM-----ESDSLRILEFRGNHLdvlwraGDNRYLDFFKNLFN---LEVLDISRNSLNSlppevfEGM 677
Cdd:COG5238   214 WLKRNPIGDEGAEILaealkGNKSLTTLDLSNNQI------GDEGVIALAEALKNnttVETLYLSGNQIGA------EGA 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  678 ppnlknLSLAKNglksffwdrLQLLKHLEILDLSHNQLT-----KVPERLANcSKSLTTLILKHNQIRQLTKYFLEDALQ 752
Cdd:COG5238   282 ------IALAKA---------LQGNTTLTSLDLSVNRIGdegaiALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQ 345

                         250
                  ....*....|....*
gi 569011716  753 ----LRYLDISSNKI 763
Cdd:COG5238   346 enttLHSLDLSDNQI 360
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 88-410 2.76e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716   88 FRRLNHLEEIDLRCNcvpVLLGSKANVCTKRLQIRPgsfsglsDLKALYLDGNQLLEIPQdlpsslhllsleannIFSIT 167
Cdd:cd00116    19 LPKLLCLQVLRLEGN---TLGEEAAKALASALRPQP-------SLKELCLSLNETGRIPR---------------GLQSL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  168 KENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLvmrnlKVLSLKDNN--------VTAVPTTLPPNLLELYL-YNN 238
Cdd:cd00116    74 LQGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSL-----QELKLNNNGlgdrglrlLAKGLKDLPPALEKLVLgRNR 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  239 IIKKIQE---NDFNNLNELQVLDLSGNCPRCYNVPYPCtpcennsplqihdNAFNSLTELKVLRLHSNSLQH-------- 307
Cdd:cd00116   149 LEGASCEalaKALRANRDLKELNLANNGIGDAGIRALA-------------EGLKANCNLEVLDLNNNGLTDegasalae 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  308 VPPTWfknmRNLQELDLSQNYL----AREIEEAkFLHFLPNLVELDFSFNYELQVyhASITLPHSLSSLENLKILRVKG- 382
Cdd:cd00116   216 TLASL----KSLEVLNLGDNNLtdagAAALASA-LLSPNISLLTLSLSCNDITDD--GAKDLAEVLAEKESLLELDLRGn 288

                         330       340
                  ....*....|....*....|....*....
gi 569011716  383 YVFKELKNSSLSVLH-KLPRLEVLDLGTN 410
Cdd:cd00116   289 KFGEEGAQLLAESLLePGNELESLWVKDD 317
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 524-763 5.93e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 5.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  524 KCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLD----LLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKL 599
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGeeaaKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQGLTKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  600 RLLDKLMMNDNDISTSASRTMES----DSLRILEFRGN-----HLDVLWRAGDNRYLDffknlfnLEVLDISRNSLNSLP 670
Cdd:cd00116    81 CGLQELDLSDNALGPDGCGVLESllrsSSLQELKLNNNglgdrGLRLLAKGLKDLPPA-------LEKLVLGRNRLEGAS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  671 PEVFEGMPP---NLKNLSLAKNGLKSFFWDRLQL----LKHLEILDLSHNQLT-----KVPERLANcSKSLTTLILKHNQ 738
Cdd:cd00116   154 CEALAKALRanrDLKELNLANNGIGDAGIRALAEglkaNCNLEVLDLNNNGLTdegasALAETLAS-LKSLEVLNLGDNN 232

                         250       260       270
                  ....*....|....*....|....*....|
gi 569011716  739 IR-----QLTKYFLEDALQLRYLDISSNKI 763
Cdd:cd00116   233 LTdagaaALASALLSPNISLLTLSLSCNDI 262
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 369-635 8.50e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 8.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  369 LSSLENLKILRVKGYVFKELKNSSL-SVLHKLPRLEVLDLGTNFIKIADLNI------FKHFENLKLIDLSVNKISPSEe 441
Cdd:cd00116    19 LPKLLCLQVLRLEGNTLGEEAAKALaSALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGPDG- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  442 sreVGFCPNAQTSvdrhgpQVLEALHYFRYDEYARSCRFKNKEPPSfLPLNADchiygqTLDLSRNNIF----FIKPSDF 517
Cdd:cd00116    98 ---CGVLESLLRS------SSLQELKLNNNGLGDRGLRLLAKGLKD-LPPALE------KLVLGRNRLEgascEALAKAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  518 QHLSFLKCLNLSGNTIG----QTLnGSELWPLRELRYLDFSNNRL----DLLYSTAFEELQSLEVLDLSSNShyFQAEGI 589
Cdd:cd00116   162 RANRDLKELNLANNGIGdagiRAL-AEGLKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNN--LTDAGA 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569011716  590 THMLN-FTKKLRLLDKLMMNDNDISTSASRTM-----ESDSLRILEFRGNHL 635
Cdd:cd00116   239 AALASaLLSPNISLLTLSLSCNDITDDGAKDLaevlaEKESLLELDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 363-580 8.63e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  363 ITLPHSLSSLENLKILrvkgYVFKelkN--SSLSVLHKLPRLEVLDLGTNFI-KIADLNifkHFENLKLIDLSVNKISPS 439
Cdd:cd21340    14 ITKIDNLSLCKNLKVL----YLYD---NkiTKIENLEFLTNLTHLYLQNNQIeKIENLE---NLVNLKKLYLGGNRISVV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  440 EesrevGFcpnaqtsvdrHGPQVLEALHYfrydEYARscrfknkeppsfLPLnadchiyGQTLDLSRNNIFFIKPSdfqh 519
Cdd:cd21340    84 E-----GL----------ENLTNLEELHI----ENQR------------LPP-------GEKLTFDPRSLAALSNS---- 121

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011716  520 lsfLKCLNLSGNTIgQTLngSELWPLRELRYLDFSNNRLDLL--YSTAFEELQSLEVLDLSSN 580
Cdd:cd21340   122 ---LRVLNISGNNI-DSL--EPLAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGN 178
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 551-763 1.04e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  551 LDFSNNRLDL----LYSTAFEELQSLEVLDLSSNS-HYFQAEGITHMLNFTKKLRLLDklmMNDNDISTS-----ASRTM 620
Cdd:COG5238   185 VYLGCNQIGDegieELAEALTQNTTVTTLWLKRNPiGDEGAEILAEALKGNKSLTTLD---LSNNQIGDEgvialAEALK 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  621 ESDSLRILEFRGNHLDVLWRAGDNRYLdffKNLFNLEVLDISRNSLNSlppEVFEGMPPNLKN------LSLAKNGLKSF 694
Cdd:COG5238   262 NNTTVETLYLSGNQIGAEGAIALAKAL---QGNTTLTSLDLSVNRIGD---EGAIALAEGLQGnktlhtLNLAYNGIGAQ 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  695 FWDRL----QLLKHLEILDLSHNQLT----KVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQ---LRYLDISSNKI 763
Cdd:COG5238   336 GAIALakalQENTTLHSLDLSDNQIGdegaIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQtnrLHTLILDGNLI 415
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 652-745 1.19e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  652 NLFNLEVLDISRNSLnsLPPEVFE-------GMPPNLKNLSLAKNGLKSFfwDRLQLLKHLEILDLSHNQLTKVPE--RL 722
Cdd:cd21340    88 NLTNLEELHIENQRL--PPGEKLTfdprslaALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDL 163

                          90       100
                  ....*....|....*....|...
gi 569011716  723 ANCSKSLTTLILKHNQIRQLTKY 745
Cdd:cd21340   164 LSSWPSLRELDLTGNPVCKKPKY 186
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 124-262 2.82e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  124 GSFSGLSDLKALYLDGNQLLEIP-------------QDlpsslhllsleaNNIFSItkENLTELVNIETLYLGQNC---- 186
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIEnlefltnlthlylQN------------NQIEKI--ENLENLVNLKKLYLGGNRisvv 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  187 ---------------YYRNPCNVSYSIEKDA-FLVMRNLKVLSLKDNNVTAVpTTLPP--NLLELYLYNNIIKKIQE--N 246
Cdd:cd21340    84 eglenltnleelhieNQRLPPGEKLTFDPRSlAALSNSLRVLNISGNNIDSL-EPLAPlrNLEQLDASNNQISDLEEllD 162

                         170
                  ....*....|....*.
gi 569011716  247 DFNNLNELQVLDLSGN 262
Cdd:cd21340   163 LLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-375 3.37e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  123 PGSFSGLSDLKALYLDGNQLL-EIPQDLPSSLHLLSLE--ANNIFSITKENLTELVNIETLYLGQNcyyrnpcNVSYSIE 199
Cdd:PLN00113  277 PPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHlfSNNFTGKIPVALTSLPRLQVLQLWSN-------KFSGEIP 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  200 KDaFLVMRNLKVLSLKDNNVTA-VPTTL--PPNLLELYLYNNIIK----------------KIQENDF------------ 248
Cdd:PLN00113  350 KN-LGKHNNLTVLDLSTNNLTGeIPEGLcsSGNLFKLILFSNSLEgeipkslgacrslrrvRLQDNSFsgelpseftklp 428

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  249 ---------NNLN-----------ELQVLDLS-----GNCPRCYNvpypctpCENNSPLQIHDNAFN--------SLTEL 295
Cdd:PLN00113  429 lvyfldisnNNLQgrinsrkwdmpSLQMLSLArnkffGGLPDSFG-------SKRLENLDLSRNQFSgavprklgSLSEL 501

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011716  296 KVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIeEAKFLHFlPNLVELDFSFNyelqvyHASITLPHSLSSLENL 375
Cdd:PLN00113  502 MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI-PASFSEM-PVLSQLDLSQN------QLSGEIPKNLGNVESL 573
PLN03150 PLN03150
hypothetical protein; Provisional
 514-581 6.37e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 6.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011716  514 PSDFQHLSFLKCLNLSGNTIGQTLNGSeLWPLRELRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNS 581
Cdd:PLN03150  435 PNDISKLRHLQSINLSGNSIRGNIPPS-LGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH