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Conserved domains on  [gi|569011915|ref|XP_006528874|]
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adhesion G-protein coupled receptor G2 isoform X6 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmB2_GPR64 cd15444
orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B ...
683-952 2.82e-166

orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors; GPR64 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR97, GPR112, GPR114, and GPR126. GPR64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


:

Pssm-ID: 320560 [Multi-domain]  Cd Length: 271  Bit Score: 489.72  E-value: 2.82e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  683 MMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNT-RGFCIAVAVFLHY 761
Cdd:cd15444     1 MLILTFITYIGCGLSAIFLSVTLVTYIAFEKIRRDYPSKILIQLCVALLLLNLVFLLDSWIALYKDiVGLCISVAVFLHY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  762 FLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISPDNYGIGSYGKFPNGTPDDFCWINSN 841
Cdd:cd15444    81 FLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGVPAVVVAIVLAVSKDNYGLGSYGKSPNGSTDDFCWINNN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  842 VVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYL 921
Cdd:cd15444   161 IVFYITVVGYFCVIFLLNISMFIVVLVQLCRIKKQKQLGAQRKTSLQDLRSVAGITFLLGITWGFAFFAWGPVNLAFMYL 240
                         250       260       270
                  ....*....|....*....|....*....|.
gi 569011915  922 FAIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15444   241 FAIFNTLQGFFIFIFYCVAKENVRKQWRRYL 271
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
619-670 3.33e-13

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


:

Pssm-ID: 460350  Cd Length: 44  Bit Score: 64.64  E-value: 3.33e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 569011915   619 VKCVFWDLGRNdtalvptgGKGGWSSDGCSVKDKRMNETICTCSHLTSFGIL 670
Cdd:pfam01825    1 PQCVFWDFTNS--------TTGRWSTEGCTTVSLNDTHTVCSCNHLTSFAVL 44
PHA03247 super family cl33720
large tegument protein UL36; Provisional
301-441 3.30e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  301 PHGPPLSSSSKPVVPQATIishvasdfSLAEPLDhALMTPSTPSLTQEsnlPSPQPTIPLASSPATDLPVQSvvvssLPQ 380
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTE--------SFALPPD-QPERPPQPQAPPP---PQPQPQPPPPPQPQPPPPPPP-----RPQ 2940
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011915  381 TDLSHTLSPVQSSIPSPTTPAP----------SVPTELVTISTPPGET-VVNTSTVSDLEA-QVSQMEKALSL 441
Cdd:PHA03247 2941 PPLAPTTDPAGAGEPSGAVPQPwlgalvpgrvAVPRFRVPQPAPSREApASSTPPLTGHSLsRVSSWASSLAL 3013
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
351-542 6.50e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14948:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 620  Bit Score: 46.88  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  351 LPSPQPTIPLASSPATDLPVQSVV----VSSLPQTDLSHTLSPVQSSIP-SPTTPAPSVPTELVTISTPPgETVVNTSTV 425
Cdd:PRK14948  360 LPSAFISEIANASAPANPTPAPNPspppAPIQPSAPKTKQAATTPSPPPaKASPPIPVPAEPTEPSPTPP-ANAANAPPS 438
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  426 SDLEAQVSQMekalsLGSLEPNLAGEMVNRVSKL--LHSPPALLApLAQRLLKVV--------DAI------GLQLNFSS 489
Cdd:PRK14948  439 LNLEELWQQI-----LAKLELPSTRMLLSQQAELvsLDSNRAVIA-VSPNWLGMVqsrkplleQAFakvlgrSIKLNLES 512
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569011915  490 TTISLTSPSLALAVIRVNASNFNTTTFAAQDPTNLQVSLETPPPENSIGAITL 542
Cdd:PRK14948  513 QSGSASNTAKTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSN 565
 
Name Accession Description Interval E-value
7tmB2_GPR64 cd15444
orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B ...
683-952 2.82e-166

orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors; GPR64 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR97, GPR112, GPR114, and GPR126. GPR64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320560 [Multi-domain]  Cd Length: 271  Bit Score: 489.72  E-value: 2.82e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  683 MMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNT-RGFCIAVAVFLHY 761
Cdd:cd15444     1 MLILTFITYIGCGLSAIFLSVTLVTYIAFEKIRRDYPSKILIQLCVALLLLNLVFLLDSWIALYKDiVGLCISVAVFLHY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  762 FLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISPDNYGIGSYGKFPNGTPDDFCWINSN 841
Cdd:cd15444    81 FLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGVPAVVVAIVLAVSKDNYGLGSYGKSPNGSTDDFCWINNN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  842 VVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYL 921
Cdd:cd15444   161 IVFYITVVGYFCVIFLLNISMFIVVLVQLCRIKKQKQLGAQRKTSLQDLRSVAGITFLLGITWGFAFFAWGPVNLAFMYL 240
                         250       260       270
                  ....*....|....*....|....*....|.
gi 569011915  922 FAIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15444   241 FAIFNTLQGFFIFIFYCVAKENVRKQWRRYL 271
7tm_2 pfam00002
7 transmembrane receptor (Secretin family); This family is known as Family B, the ...
683-933 2.17e-63

7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.


Pssm-ID: 459625 [Multi-domain]  Cd Length: 248  Bit Score: 215.22  E-value: 2.17e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915   683 MMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDyPSKILIQLCAALLLLNLIFLLDSWIALYNTRGF------CIAVA 756
Cdd:pfam00002    1 ALSLKVIYTVGYSLSLVALLLAIAIFLLFRKLHCT-RNYIHLNLFASFILRALLFLVGDAVLFNKQDLDhcswvgCKVVA 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915   757 VFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYiRKYILKFCIVGWGIPAVVVSIVLTISPDNYGigsygkfpngtPDDFC 836
Cdd:pfam00002   80 VFLHYFFLANFFWMLVEGLYLYTLLVEVFFSE-RKYFWWYLLIGWGVPALVVGIWAGVDPKGYG-----------EDDGC 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915   837 WINSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSI-QDLRSIAGLTFLLGITWGFAFFAWGPVN 915
Cdd:pfam00002  148 WLSNENGLWWIIRGPILLIILVNFIIFINIVRILVQKLRETNMGKSDLKQYrRLAKSTLLLLPLLGITWVFGLFAFNPEN 227
                          250       260
                   ....*....|....*....|.
gi 569011915   916 ---VTFMYLFAIFNTLQGFFI 933
Cdd:pfam00002  228 tlrVVFLYLFLILNSFQGFFV 248
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
619-670 3.33e-13

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


Pssm-ID: 460350  Cd Length: 44  Bit Score: 64.64  E-value: 3.33e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 569011915   619 VKCVFWDLGRNdtalvptgGKGGWSSDGCSVKDKRMNETICTCSHLTSFGIL 670
Cdd:pfam01825    1 PQCVFWDFTNS--------TTGRWSTEGCTTVSLNDTHTVCSCNHLTSFAVL 44
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
618-675 1.19e-12

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 63.18  E-value: 1.19e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 569011915    618 TVKCVFWDLGRndtalvptggkGGWSSDGCSVKDKRMNETICTCSHLTSFGILLDLSR 675
Cdd:smart00303    2 NPICVFWDESS-----------GEWSTRGCELLETNGTHTTCSCNHLTTFAVLMDVPP 48
PHA03247 PHA03247
large tegument protein UL36; Provisional
301-441 3.30e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  301 PHGPPLSSSSKPVVPQATIishvasdfSLAEPLDhALMTPSTPSLTQEsnlPSPQPTIPLASSPATDLPVQSvvvssLPQ 380
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTE--------SFALPPD-QPERPPQPQAPPP---PQPQPQPPPPPQPQPPPPPPP-----RPQ 2940
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011915  381 TDLSHTLSPVQSSIPSPTTPAP----------SVPTELVTISTPPGET-VVNTSTVSDLEA-QVSQMEKALSL 441
Cdd:PHA03247 2941 PPLAPTTDPAGAGEPSGAVPQPwlgalvpgrvAVPRFRVPQPAPSREApASSTPPLTGHSLsRVSSWASSLAL 3013
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
351-542 6.50e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 46.88  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  351 LPSPQPTIPLASSPATDLPVQSVV----VSSLPQTDLSHTLSPVQSSIP-SPTTPAPSVPTELVTISTPPgETVVNTSTV 425
Cdd:PRK14948  360 LPSAFISEIANASAPANPTPAPNPspppAPIQPSAPKTKQAATTPSPPPaKASPPIPVPAEPTEPSPTPP-ANAANAPPS 438
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  426 SDLEAQVSQMekalsLGSLEPNLAGEMVNRVSKL--LHSPPALLApLAQRLLKVV--------DAI------GLQLNFSS 489
Cdd:PRK14948  439 LNLEELWQQI-----LAKLELPSTRMLLSQQAELvsLDSNRAVIA-VSPNWLGMVqsrkplleQAFakvlgrSIKLNLES 512
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569011915  490 TTISLTSPSLALAVIRVNASNFNTTTFAAQDPTNLQVSLETPPPENSIGAITL 542
Cdd:PRK14948  513 QSGSASNTAKTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSN 565
KLF8_12_N cd21093
N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins; Kruppel-like ...
324-402 4.62e-03

N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins; Kruppel-like transcription factors (also known as Krueppel-like transcription factors, KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. This model represents the related N-terminal activation/repression domains of KLF8 and KLF12.


Pssm-ID: 410606 [Multi-domain]  Cd Length: 172  Bit Score: 39.37  E-value: 4.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  324 ASDFSL--AEPLDHALMTPSTPSLTQESNLPSPQPTIPLASSPAtdlPVQSVVVSSLpqtdlshTLSPVQSSIPSPTTPA 401
Cdd:cd21093    29 SSDHSQpqTEPVDLSINKARTSPTAVSSSPVSMSSSISSSSSSS---PRPASSPTVI-------TSVSSASAIPTVLSPG 98

                  .
gi 569011915  402 P 402
Cdd:cd21093    99 S 99
 
Name Accession Description Interval E-value
7tmB2_GPR64 cd15444
orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B ...
683-952 2.82e-166

orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors; GPR64 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR97, GPR112, GPR114, and GPR126. GPR64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320560 [Multi-domain]  Cd Length: 271  Bit Score: 489.72  E-value: 2.82e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  683 MMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNT-RGFCIAVAVFLHY 761
Cdd:cd15444     1 MLILTFITYIGCGLSAIFLSVTLVTYIAFEKIRRDYPSKILIQLCVALLLLNLVFLLDSWIALYKDiVGLCISVAVFLHY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  762 FLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISPDNYGIGSYGKFPNGTPDDFCWINSN 841
Cdd:cd15444    81 FLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGVPAVVVAIVLAVSKDNYGLGSYGKSPNGSTDDFCWINNN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  842 VVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYL 921
Cdd:cd15444   161 IVFYITVVGYFCVIFLLNISMFIVVLVQLCRIKKQKQLGAQRKTSLQDLRSVAGITFLLGITWGFAFFAWGPVNLAFMYL 240
                         250       260       270
                  ....*....|....*....|....*....|.
gi 569011915  922 FAIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15444   241 FAIFNTLQGFFIFIFYCVAKENVRKQWRRYL 271
7tmB2_GPR112 cd15997
Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane ...
686-952 1.50e-139

Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR112 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR114, and GPR126. GPR112 is specifically expressed in normal enterochromatin cells and gastrointestinal neuroendocrine carcinoma cells, but its biological function is unknown. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320663  Cd Length: 269  Bit Score: 420.61  E-value: 1.50e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  686 LTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHYFLLV 765
Cdd:cd15997     4 LTLITYLGCGISSIFLGITLVTYLAFEKLRRDYPSKILINLCTALLMLNLVFLLNSWLSSFNNYGLCITVAAFLHYFLLA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  766 SFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISPDNYGIGSYGKFPNGTpDDFCWINSNVVFY 845
Cdd:cd15997    84 SFTWMGLEAVHMYFALVKVFNIYIPNYILKFCIAGWGIPAVVVALVLAINKDFYGNELSSDSLHPS-TPFCWIQDDVVFY 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  846 ITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYLFAIF 925
Cdd:cd15997   163 ISVVAYFCLIFLCNISMFITVLIQIRSMKAKKPSRNWKQGFLHDLKSVASLTFLLGLTWGFAFFAWGPVRIFFLYLFSIC 242
                         250       260
                  ....*....|....*....|....*..
gi 569011915  926 NTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15997   243 NTLQGFFIFVFHCLMKENVRKQWRIHL 269
7tmB2_GPR126-like_Adhesion_VIII cd15258
orphan GPR126 and related proteins, group VIII adhesion GPCRs, member of the class B2 family ...
683-950 3.49e-138

orphan GPR126 and related proteins, group VIII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Group VIII adhesion GPCRs include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, GPR114, and GPR126. GPR56 is involved in the regulation of oligodendrocyte development and myelination in the central nervous system via coupling to G(12/13) proteins, which leads to the activation of RhoA GTPase. GPR126, on the other hand, is required for Schwann cells, but not oligodendrocyte myelination in the peripheral nervous system. Gpr64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. GPR97 is identified as a lymphatic adhesion receptor that is specifically expressed in lymphatic endothelium, but not in blood vascular endothelium, and is shown to regulate migration of lymphatic endothelial cells via the small GTPases RhoA and cdc42. GPR112 is specifically expressed in normal enterochromatin cells and gastrointestinal neuroendocrine carcinoma cells, but its biological function is unknown. GPR114 is mainly found in granulocytes (polymorphonuclear leukocytes), and GPR114-transfected cells induced an increase in cAMP levels via coupling to G(s) protein. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320386 [Multi-domain]  Cd Length: 267  Bit Score: 416.82  E-value: 3.49e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  683 MMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHYF 762
Cdd:cd15258     1 LHILTFISYVGCGISAIFLAITILTYIAFRKLRRDYPSKIHMNLCAALLLLNLAFLLSSWIASFGSDGLCIAVAVALHYF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  763 LLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISPDNYGIGSYGKFPNGTPDDFCWINSNV 842
Cdd:cd15258    81 LLACLTWMGLEAFHLYLLLVKVFNTYIRRYILKLCLVGWGLPALLVTLVLSVRSDNYGPITIPNGEGFQNDSFCWIRDPV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  843 VFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLgAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYLF 922
Cdd:cd15258   161 VFYITVVGYFGLTFLFNMVMLATVLVQICRLREKAQA-TPRKRALHDLLTLLGLTFLLGLTWGLAFFAWGPFNLPFLYLF 239
                         250       260
                  ....*....|....*....|....*...
gi 569011915  923 AIFNTLQGFFIFIFYCAAKENVRKQWRR 950
Cdd:cd15258   240 AIFNSLQGFFIFIWYCSMKENVRKQWRA 267
7tmB2_GPR126 cd15996
orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G ...
686-952 4.07e-124

orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR126 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, and GPR114. GPR126 is required in Schwann cells for proper differentiation and myelination via G-Protein Activation. GPR126 is believed to couple to G(s)-protein, which leads to activation of adenylate cyclase for cAMP production. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320662  Cd Length: 271  Bit Score: 380.39  E-value: 4.07e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  686 LTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHYFLLV 765
Cdd:cd15996     4 LTFITYIGCGISAIFSAATLLTYIAFEKLRRDYPSKILMNLSTALLFLNLVFLLDGWIASFEIDELCITVAVLLHFFLLA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  766 SFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISPDNYGIGSYGKFPNGT-PDDFCWINSNVVF 844
Cdd:cd15996    84 TFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIIGWGLPALIVSIVLASTNDNYGYGYYGKDKDGQgGDEFCWIKNPVVF 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  845 YITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYLFAI 924
Cdd:cd15996   164 YVTCAAYFGIMFLMNVAMFIVVMVQICGRNGKRSNRTLREEILRNLRSVVSLTFLLGMTWGFAFFAWGPVNLAFMYLFTI 243
                         250       260
                  ....*....|....*....|....*...
gi 569011915  925 FNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15996   244 FNSLQGLFIFVFHCALKENVQKQWRRHL 271
7tmB2_Adhesion cd15040
adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G ...
685-948 6.46e-88

adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G protein-coupled receptors; The B2 subfamily of class B GPCRs consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320168 [Multi-domain]  Cd Length: 253  Bit Score: 283.31  E-value: 6.46e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  685 ALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWiaLYNTRGFCIAVAVFLHYFLL 764
Cdd:cd15040     3 ALSIITYIGCGLSLLGLLLTIITYILFRKLRKRKPTKILLNLCLALLLANLLFLFGIN--STDNPVLCTAVAALLHYFLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  765 VSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISPDNYgigsygkfpnGTPDDFCWINSNVVF 844
Cdd:cd15040    81 ASFMWMLVEALLLYLRLVKVFGTYPRHFILKYALIGWGLPLIIVIITLAVDPDSY----------GNSSGYCWLSNGNGL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  845 YITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQdLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYLFAI 924
Cdd:cd15040   151 YYAFLGPVLLIILVNLVIFVLVLRKLLRLSAKRNKKKRKKTKAQ-LRAAVSLFFLLGLTWIFGILAIFGARVVFQYLFAI 229
                         250       260
                  ....*....|....*....|....
gi 569011915  925 FNTLQGFFIFIFYCAAKENVRKQW 948
Cdd:cd15040   230 FNSLQGFFIFIFHCLRNKEVRKAW 253
7tm_classB cd13952
class B family of seven-transmembrane G protein-coupled receptors; The class B of ...
685-948 2.19e-71

class B family of seven-transmembrane G protein-coupled receptors; The class B of seven-transmembrane GPCRs is classified into three major subfamilies: subfamily B1 (secretin-like receptor family), B2 (adhesion family), and B3 (Methuselah-like family). The class B receptors have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi or prokaryotes. The B1 subfamily comprises receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the subfamily B1 receptors preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The subfamily B2 consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Furthermore, the subfamily B3 includes Methuselah (Mth) protein, which was originally identified in Drosophila as a GPCR affecting stress resistance and aging, and its closely related proteins.


Pssm-ID: 410627 [Multi-domain]  Cd Length: 260  Bit Score: 238.27  E-value: 2.19e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  685 ALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRdYPSKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHYFLL 764
Cdd:cd13952     3 ALSIITYIGCSLSLVGLLLTIITYLLFPKLRN-LRGKILINLCLSLLLAQLLFLIGQLLTSSDRPVLCKALAILLHYFLL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  765 VSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISPDNYGIGSYGKfpngtpDDFCWINSNVVF 844
Cdd:cd13952    82 ASFFWMLVEAFDLYRTFVKVFGSSERRRFLKYSLYGWGLPLLIVIITAIVDFSLYGPSPGYG------GEYCWLSNGNAL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  845 YITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAW-GPVNVTFMYLFA 923
Cdd:cd13952   156 LWAFYGPVLLILLVNLVFFILTVRILLRKLRETPKQSERKSDRKQLRAYLKLFPLMGLTWIFGILAPfVGGSLVFWYLFD 235
                         250       260
                  ....*....|....*....|....*
gi 569011915  924 IFNTLQGFFIFIFYCAAKENVRKQW 948
Cdd:cd13952   236 ILNSLQGFFIFLIFCLKNKEVRRLL 260
7tm_2 pfam00002
7 transmembrane receptor (Secretin family); This family is known as Family B, the ...
683-933 2.17e-63

7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.


Pssm-ID: 459625 [Multi-domain]  Cd Length: 248  Bit Score: 215.22  E-value: 2.17e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915   683 MMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDyPSKILIQLCAALLLLNLIFLLDSWIALYNTRGF------CIAVA 756
Cdd:pfam00002    1 ALSLKVIYTVGYSLSLVALLLAIAIFLLFRKLHCT-RNYIHLNLFASFILRALLFLVGDAVLFNKQDLDhcswvgCKVVA 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915   757 VFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYiRKYILKFCIVGWGIPAVVVSIVLTISPDNYGigsygkfpngtPDDFC 836
Cdd:pfam00002   80 VFLHYFFLANFFWMLVEGLYLYTLLVEVFFSE-RKYFWWYLLIGWGVPALVVGIWAGVDPKGYG-----------EDDGC 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915   837 WINSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSI-QDLRSIAGLTFLLGITWGFAFFAWGPVN 915
Cdd:pfam00002  148 WLSNENGLWWIIRGPILLIILVNFIIFINIVRILVQKLRETNMGKSDLKQYrRLAKSTLLLLPLLGITWVFGLFAFNPEN 227
                          250       260
                   ....*....|....*....|.
gi 569011915   916 ---VTFMYLFAIFNTLQGFFI 933
Cdd:pfam00002  228 tlrVVFLYLFLILNSFQGFFV 248
7tmB2_GPR114 cd15443
orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G ...
686-945 2.34e-57

orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR114 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include GPR56, GPR64, GPR97, GPR112, and GPR126. GPR114 is mainly found in granulocytes (polymorphonuclear leukocytes), and GPR114-transfected cells induced an increase in cAMP levels via coupling to G(s) protein. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320559 [Multi-domain]  Cd Length: 268  Bit Score: 199.21  E-value: 2.34e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  686 LTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHYFLLV 765
Cdd:cd15443     4 LTYISIVGCSISAAASLLTILLHFFSRKQPKDSTTRIHMNLLGSLFLLNGSFLLSPPLATSQSTWLCRAAAALLHYSLLC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  766 SFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISPDNYG---IGSYGKFPNGTpddFCWINSNV 842
Cdd:cd15443    84 CLTWMAIEGFHLYLLLVKVYNIYIRRYVLKLCVLGWGLPALIVLLVLIFKREAYGphtIPTGTGYQNAS---MCWITSSK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  843 VFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRktSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYLF 922
Cdd:cd15443   161 VHYVLVLGYAGLTSLFNLVVLAWVVRMLRRLRSRKQELGER--ARRDWVTVLGLTCLLGTTWALAFFSFGVFLIPQLFLF 238
                         250       260
                  ....*....|....*....|...
gi 569011915  923 AIFNTLQGFFIFIFYCAAKENVR 945
Cdd:cd15443   239 TIINSLYGFFICLWYCTQRRRSD 261
7tmB2_GPR97 cd15442
orphan adhesion receptor GPR97, member of the class B2 family of seven-transmembrane G ...
686-937 1.44e-56

orphan adhesion receptor GPR97, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR97 is an orphan receptor that has been classified into the group VIII of adhesion GPCRs. Other members of the Group VII include GPR56, GPR64, GPR112, GPR114, and GPR126. GPR97 is identified as a lymphatic adhesion receptor that is specifically expressed in lymphatic endothelium, but not in blood vascular endothelium, and is shown to regulate migration of lymphatic endothelial cells via the small GTPases RhoA and cdc42. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320558 [Multi-domain]  Cd Length: 277  Bit Score: 197.33  E-value: 1.44e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  686 LTFITYIGCGLSSIFLSVTLVTYIA----FEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHY 761
Cdd:cd15442     4 LVTISSAGCGVSMVFLIFTIILYFFlrftYQKFKSEDAPKIHVNLSSSLLLLNLAFLLNSGVSSRAHPGLCKALGGVTHY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  762 FLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTispdnygIGSYGKF-----PNGTPDDFC 836
Cdd:cd15442    84 FLLCCFTWMAIEAFHLYLLAIKVFNTYIHHYFAKLCLVGWGFPALVVTITGS-------INSYGAYtimdmANRTTLHLC 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  837 WINSN--VVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLrSIAGLTFLLGITWGFAFFAWGPV 914
Cdd:cd15442   157 WINSKhlTVHYITVCGYFGLTFLFNTVVLGLVAWKIFHLQSATAGKEKCQAWKGGL-TVLGLSCLLGVTWGLAFFTYGSM 235
                         250       260
                  ....*....|....*....|...
gi 569011915  915 NVTFMYLFAIFNTLQGFFIFIFY 937
Cdd:cd15442   236 SVPTVYIFALLNSLQGLFIFIWF 258
7tmB2_latrophilin-like_invertebrate cd15440
invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane ...
685-952 7.48e-47

invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors; This subgroup includes latrophilin-like proteins that are found in invertebrates such as insects and worms. Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of vertebrate latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320556 [Multi-domain]  Cd Length: 259  Bit Score: 168.60  E-value: 7.48e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  685 ALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDypsKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHYFLL 764
Cdd:cd15440     3 ALTFITYIGCIISIVCLLLAFITFTCFRNLQCD---RNTIHKNLCLCLLIAEIVFLLGIDQTENRTLCGVIAGLLHYFFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  765 VSFTWMGLEAFHMYLALVKVFNTYIRKyILKFCIVGWGIPAVVVSIVLTISPDNYGIgsygkfpngtpDDFCWINSNVVF 844
Cdd:cd15440    80 AAFSWMLLEGFQLYVMLVEVFEPEKSR-IKWYYLFGYGLPALIVAVSAGVDPTGYGT-----------EDHCWLSTENGF 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  845 YITVVGYFCVIFLLNVSMFIVVLVQLCRIKK--KKQLGAQRKTSIQD-LRSIAGLTFLLGITWGFAFFAWGPVNVTFMYL 921
Cdd:cd15440   148 IWSFVGPVIVVLLANLVFLGMAIYVMCRHSSrsASKKDASKLKNIRGwLKGSIVLVVLLGLTWTFGLLFINQESIVMAYI 227
                         250       260       270
                  ....*....|....*....|....*....|.
gi 569011915  922 FAIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15440   228 FTILNSLQGLFIFIFHCVLNEKVRKELRRWL 258
7tmB2_GPR56 cd15995
orphan adhesion receptor GPR56, member of the class B2 family of seven-transmembrane G ...
686-946 1.95e-44

orphan adhesion receptor GPR56, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR56 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR64, GPR97, GPR112, GPR114, and GPR126. GPR56 is involved in the regulation of oligodendrocyte development and myelination in the central nervous system via coupling to G(12/13) proteins, which leads to the activation of RhoA GTPase. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320661  Cd Length: 269  Bit Score: 161.92  E-value: 1.95e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  686 LTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHYFLLV 765
Cdd:cd15995     4 LTILTYVGCIISALASVFTIAFYLCSRRKPRDYTIYVHMNLLLAIFLLDTSFLISEPLALTGSEAACRAGGMFLHFSLLA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  766 SFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISPDNYGIGSYGKF--PNG-TPDDFCWINSNV 842
Cdd:cd15995    84 CLTWMGIEGYNLYRLVVEVFNTYVPHFLLKLCAVGWGLPIFLVTLIFLVDQDNYGPIILAVHrsPEKvTYATICWITDSL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  843 VFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQlgaqrktSIQDLRSIAGLTFLLGITWGFAFFAW--GPVNVTFMY 920
Cdd:cd15995   164 ISNITNLGLFSLVFLFNMAMLATMVVEILRLRPRTH-------KWSHVLTLLGLSLVLGIPWALAFFSFasGTFQLVIVY 236
                         250       260
                  ....*....|....*....|....*.
gi 569011915  921 LFAIFNTLQGFFIFIFYCAAKENVRK 946
Cdd:cd15995   237 LFTIINSLQGFLIFLWYWSMVLQARG 262
7tmB2_GPR133-like_Adhesion_V cd15933
orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of ...
684-948 2.04e-42

orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group V adhesion GPCRs include orphan receptors GPR133, GPR144, and closely related proteins. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the G(s) protein, leading to activation of adenylate cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320599 [Multi-domain]  Cd Length: 252  Bit Score: 155.56  E-value: 2.04e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  684 MALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYpSKILIQLCAALLLLNLIFLLDSWIALYNTrgFCIAVAVFLHYFL 763
Cdd:cd15933     2 RALSIISYIGCGISIACLALTLIIFLVLRVLSSDR-FQIHKNLCVALLLAQILLLAGEWAEGNKV--ACKVVAILLHFFF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  764 LVSFTWMGLEAFHMYLALVKVFNTYIRKYIlkFCIVGWGIPAVVVSIVLTISPDNYGigsygkfpngtPDDFCWINSNVV 843
Cdd:cd15933    79 MAAFSWMLVEGLHLYLMIVKVFNYKSKMRY--YYFIGWGLPAIIVAISLAILFDDYG-----------SPNVCWLSLDDG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  844 FYITVVGyfCVIFLLNVSMFIVVLV-----QLCRIKKKKQLG--AQRKTSIqdlRSIAGLTFLLGITWGFAFFAWGPVNV 916
Cdd:cd15933   146 LIWAFVG--PVIFIITVNTVILILVvkitvSLSTNDAKKSQGtlAQIKSTA---KASVVLLPILGLTWLFGVLVVNSQTI 220
                         250       260       270
                  ....*....|....*....|....*....|..
gi 569011915  917 TFMYLFAIFNTLQGFFIFIFYCAAKENVRKQW 948
Cdd:cd15933   221 VFQYIFVILNSLQGLMIFLFHCVLNSEVRSAF 252
7tmB2_CELSR_Adhesion_IV cd15441
cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 ...
751-953 3.86e-40

cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuron migration and axon guidance in the CNS.


Pssm-ID: 320557 [Multi-domain]  Cd Length: 254  Bit Score: 148.94  E-value: 3.86e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  751 FCIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNtyIRKYILKFC-IVGWGIPAVVVSIVLTISPDNYGigsygkfpn 829
Cdd:cd15441    66 PCKLIAILLHYFYLSAFSWLLVESLHLYRMLTEPRD--INHGHMRFYyLLGYGIPAIIVGLSVGLRPDGYG--------- 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  830 gtPDDFCWINSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQlgaqRKTSIQ-DLRSIAGLTFLLGITWGFAF 908
Cdd:cd15441   135 --NPDFCWLSVNETLIWSFAGPIAFVIVITLIIFILALRASCTLKRHVL----EKASVRtDLRSSFLLLPLLGATWVFGL 208
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 569011915  909 FAWGPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRYLC 953
Cdd:cd15441   209 LAVNEDSELLHYLFAGLNFLQGLFIFLFYCIFNKKVRRELKNALL 253
7tmB2_EMR cd15439
epidermal growth factor-like module-containing mucin-like hormone receptors, member of the ...
685-954 8.44e-37

epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4) and the leukocyte cell-surface antigen CD97, are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying number of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of EMR2, alternative splicing results in four isoforms possessing either two (EGF1,2), three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320555 [Multi-domain]  Cd Length: 263  Bit Score: 139.78  E-value: 8.44e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  685 ALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLdswIALYNTRGFCIAVAVFLHYFLL 764
Cdd:cd15439     3 ALTVITYVGLIISLLCLFLAILTFLLCRSIRNTSTSLHLQLSLCLFLADLLFLVG---IDRTDNKVLCSIIAGFLHYLFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  765 VSFTWMGLEAFHMYLAL--VKVFN-TYIRKYILKF-CIVGWGIPAVVVSIVLTISPDNYGIGSYgkfpngtpddfCWINS 840
Cdd:cd15439    80 ACFAWMFLEAVHLFLTVrnLKVVNyFSSHRFKKRFmYPVGYGLPAVIVAISAAVNPQGYGTPKH-----------CWLSM 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  841 NVVFYITVVGYFCVIFLLNVSMFIVVLVQLcriKKK-----KQLGAQRKTSIQDLRSIAGLtFLLGITWGFAFFAWGPVN 915
Cdd:cd15439   149 EKGFIWSFLGPVCVIIVINLVLFCLTLWIL---REKlsslnAEVSTLKNTRLLTFKAIAQL-FILGCTWILGLFQVGPVA 224
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 569011915  916 VTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRYLCC 954
Cdd:cd15439   225 TVMAYLFTITNSLQGVFIFLVHCLLNRQVREEYRRWITG 263
7tmB2_Latrophilin_Adhesion_I cd15252
Latrophilins and similar receptors, group I adhesion GPCRs, member of class B2 family of ...
684-952 1.32e-36

Latrophilins and similar receptors, group I adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; Group I adhesion GPCRs consist of latrophilins (also called lectomedins or latrotoxin receptors) and ETL (EGF-TM7-latrophilin-related protein. These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320380 [Multi-domain]  Cd Length: 257  Bit Score: 139.18  E-value: 1.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  684 MALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDypsKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHYFL 763
Cdd:cd15252     2 NILTRITQVGIIISLVCLAICIFTFWFFRGLQSD---RTTIHKNLCISLFLAELVFLIGINTTTNKIFCSVIAGLLHYFF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  764 LVSFTWMGLEAFHMYLALVKVFNT--YIRKYilkFCIVGWGIPAVVVSIVLTISPDNYGIgsygkfpngtpDDFCWINSN 841
Cdd:cd15252    79 LAAFAWMFIEGIQLYLMLVEVFENegSRHKN---FYIFGYGSPAVIVGVSAALGYRYYGT-----------TKVCWLSTE 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  842 VVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQD-LRSIAGLTFLLGITWGFAFFAWGPVNVTFMY 920
Cdd:cd15252   145 NYFIWSFIGPATLIILLNLIFLGVAIYKMFRHTAGLKPEVSCLENIRSwARGAIALLFLLGLTWIFGVLHINHASVVMAY 224
                         250       260       270
                  ....*....|....*....|....*....|..
gi 569011915  921 LFAIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15252   225 LFTVSNSLQGMFIFLFHCVLSRKVRKEYYKLF 256
7tmB3_Methuselah-like cd15039
Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G ...
689-950 2.46e-36

Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G protein-coupled receptors; The subfamily B3 of class B GPCRs consists of Methuselah (Mth) and its closely related proteins found in bilateria. Mth was originally identified in Drosophila as a GPCR affecting stress resistance and aging. In addition to the seven transmembrane helices, Mth contains an N-terminal extracellular domain involved in ligand binding, and a third intracellular loop (IC3) required for the specificity of G-protein coupling. Drosophila Mth mutants showed an increase in average lifespan by 35% and greater resistance to a variety of stress factors, including starvation, high temperature, and paraquat-induced oxidative toxicity. Moreover, mutations in two endogenous peptide ligands of Methuselah, Stunted A and B, showed an increased in lifespan and resistance to oxidative stress induced by dietary paraquat. These results strongly suggest that the Stunted-Methuselah system plays important roles in stress response and aging.


Pssm-ID: 410632 [Multi-domain]  Cd Length: 270  Bit Score: 138.51  E-value: 2.46e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  689 ITYIGCGLSSIFLSVTLVTYIAFEKIRrDYPSKILIQLCAALLLLNLIFLLDSWIALYNTRgFCIAVAVFLHYFLLVSFT 768
Cdd:cd15039     7 LTLIGLIISLVFLLLTLAVYALLPELR-NLHGKCLMCLVLSLFVAYLLLLIGQLLSSGDST-LCVALGILLHFFFLAAFF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  769 WMGLEAFHMYLAL----VKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTIS---PDNYGIGSYGkfpngtpDDFCWINSN 841
Cdd:cd15039    85 WLNVMSFDIWRTFrgkrSSSSRSKERKRFLRYSLYAWGVPLLLVAVTIIVDfspNTDSLRPGYG-------EGSCWISNP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  842 VVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKK-KQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAW-GPVNVTFM 919
Cdd:cd15039   158 WALLLYFYGPVALLLLFNIILFILTAIRIRKVKKEtAKVQSRLRSDKQRFRLYLKLFVIMGVTWILEIISWfVGGSSVLW 237
                         250       260       270
                  ....*....|....*....|....*....|..
gi 569011915  920 YLFAIFNTLQGFFIF-IFYCaaKENVRKQWRR 950
Cdd:cd15039   238 YIFDILNGLQGVFIFlIFVC--KRRVLRLLKK 267
7tmB2_CD97 cd15438
CD97 antigen, member of the class B2 family of seven-transmembrane G protein-coupled receptors; ...
686-953 1.02e-31

CD97 antigen, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the leukocyte cell-surface antigen CD97 and the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4), are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily B2 of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying numbers of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of CD97, alternative splicing results in three isoforms possessing either three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. For example, CD97, which is involved in angiogenesis and the migration and invasion of tumor cells, has been shown to promote cell aggregation in a GPS proteolysis-dependent manner. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320554 [Multi-domain]  Cd Length: 261  Bit Score: 124.88  E-value: 1.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  686 LTFITYIGCGLSSIFLSVTLVTYIAfekIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHYFLLV 765
Cdd:cd15438     4 LTLITKVGLSVSLFCLFLCILTFLF---CRSIRGTRNTIHLHLCLSLFLAHLIFLLGINNTNNQVACAVVAGLLHYFFLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  766 SFTWMGLEAFHMYLALVKVFNTYIRKYiLKFCIVGWGIPAVVVSIVLTISPDNYGigsygkfpngtPDDFCWINSNVVFY 845
Cdd:cd15438    81 AFCWMSLEGVELYLMVVQVFNTQSLKK-RYLLLIGYGVPLVIVAISAAVNSKGYG-----------TQRHCWLSLERGFL 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  846 ITVVGYFCVIFLLNVSMFIVVLVQLCR--IKKKKQLGAQRKTSIQDLRSIAGLtFLLGITWGFAFFAWGPVNVTFMYLFA 923
Cdd:cd15438   149 WSFLGPVCLIILVNAIIFVITVWKLAEkfSSINPDMEKLRKIRALTITAIAQL-CILGCTWIFGFFQFSDSTLVMSYLFT 227
                         250       260       270
                  ....*....|....*....|....*....|
gi 569011915  924 IFNTLQGFFIFIFYCAAKENVRKQWRRYLC 953
Cdd:cd15438   228 ILNSLQGLFIFLLHCLLSKQVREEYSRWLC 257
7tmB2_GPR128 cd15257
orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G ...
685-946 8.83e-31

orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR128 is an orphan receptor of the adhesion family (subclass B2) that belongs to the class B GPCRs. Expression of GPR128 was detected in the mouse intestinal mucosa and is thought to be involved in energy balance, as its knockout mice showed a decrease in body weight gain and an increase in intestinal contraction frequency compared to wild-type controls. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320385 [Multi-domain]  Cd Length: 303  Bit Score: 123.44  E-value: 8.83e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  685 ALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKI-----------------------LIQLCAALLLLNLIFLLDS 741
Cdd:cd15257     3 TLDIISTIGCVLSIAGLVITIIFHLHTRKLRKSSVTWVllnlcsslllfniiftsgventnNDYEISTVPDRETNTVLLS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  742 WIALYNTRGFCIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAVVVSIVLTISpdnygI 821
Cdd:cd15257    83 EEYVEPDTDVCTAVAALLHYFLLVTFMWNAVYSAQLYLLLIRMMKPLPEMFILQASAIGWGIPAVVVAITLGAT-----Y 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  822 GSYGKFPNGTPD----DFCWI---NSNVVF-------YITVVGyfcVIFLLNVSMFIVVLVQLCriKKKKQLGAQRKTSI 887
Cdd:cd15257   158 RFPTSLPVFTRTyrqeEFCWLaalDKNFDIkkpllwgFLLPVG---LILITNVILFIMTSQKVL--KKNNKKLTTKKRSY 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011915  888 QDLRSIA-GLTFLLGITWGFAFFAW---GPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRK 946
Cdd:cd15257   233 MKKIYITvSVAVVFGITWILGYLMLvnnDLSKLVFSYIFCITNTTQGVQIFILYTWRTPEFRK 295
7tmB2_Latrophilin-1 cd16007
Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled ...
752-952 1.81e-29

Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320673 [Multi-domain]  Cd Length: 258  Bit Score: 118.49  E-value: 1.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNT-YIRKYILKFCivGWGIPAVVVSIVLTISPDNYGIgsygkfpng 830
Cdd:cd16007    67 CPIFAGLLHFFFLAAFSWLCLEGVQLYLMLVEVFESeYSRKKYYYLC--GYCFPALVVGISAAIDYRSYGT--------- 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  831 tpDDFCWINSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQD--LRSIAgLTFLLGITWGFAF 908
Cdd:cd16007   136 --EKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSwaLGAIT-LLFLLGLTWAFGL 212
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 569011915  909 FAWGPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd16007   213 LFINKESVVMAYLFTTFNAFQGMFIFIFHCALQKKVHKEYSKCL 256
7tmB2_GPR133 cd15256
orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G ...
684-949 1.71e-28

orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR133 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR144. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320384 [Multi-domain]  Cd Length: 260  Bit Score: 115.79  E-value: 1.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  684 MALTFITYIGCGLSSIFLSVTLVTYIAFEKIrrdypSKILIQLCAALLLLNLIFLLDSWIALYNTRGF-----CIAVAVF 758
Cdd:cd15256     2 VALSSITYVGCSLSIFCLAITLVTFAVLSSV-----STIRNQRYHIHANLSFAVLVAQILLLISFRFEpgtlpCKIMAIL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  759 LHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIvGWGIPAVVVSIVLTISPDNYGigsygkfpngtPDDFCWI 838
Cdd:cd15256    77 LHFFFLSAFAWMLVEGLHLYSMVIKVFGSEESKHFYYYGI-GWGSPLLICIISLTSALDSYG-----------ESDNCWL 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  839 N-SNVVFYITVVGYFCVIfLLNVSMFIVVLVQLCRIKKKkQLGAQRKTSIQDL--RSIAGLTFLLGITWGFAFFAWGPVN 915
Cdd:cd15256   145 SlENGAIWAFVAPALFVI-VVNIGILIAVTRVISRISAD-NYKVHGDANAFKLtaKAVAVLLPILGSSWVFGVLAVNTHA 222
                         250       260       270
                  ....*....|....*....|....*....|....
gi 569011915  916 VTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWR 949
Cdd:cd15256   223 LVFQYMFAIFNSLQGFFIFLFHCLLNSEVRAAFK 256
7tmB2_Latrophilin cd15436
Latrophilins, member of the class B2 family of seven-transmembrane G protein-coupled receptors; ...
752-952 3.14e-27

Latrophilins, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320552 [Multi-domain]  Cd Length: 258  Bit Score: 111.81  E-value: 3.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYI--RKYilkFCIVGWGIPAVVVSIVLTISPDNYGigsygkfpn 829
Cdd:cd15436    67 CPIFAGLLHFFFLAAFCWLCLEGVQLYLLLVEVFESEYsrRKY---FYLCGYSFPALVVAVSAAIDYRSYG--------- 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  830 gtPDDFCWINSNVVFYITVVGYFCVIFLLNVsmfIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIA----GLTFLLGITWG 905
Cdd:cd15436   135 --TEKACWLRVDNYFIWSFIGPVTFVITLNL---VFLVITLHKMVSHSDLLKPDSSRLDNIKSWAlgaiALLFLLGLTWS 209
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 569011915  906 FAFFAWGPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15436   210 FGLMFINEESVVMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYSKCL 256
7tmB2_CELSR1 cd15991
Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of ...
752-952 5.02e-27

Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320657 [Multi-domain]  Cd Length: 254  Bit Score: 111.09  E-value: 5.02e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNT---YIRKYIlkfcIVGWGIPAVVVSIVLTISPDNYGigsygkfp 828
Cdd:cd15991    67 CTVVAILLHYFYMSTFAWMFVEGLHIYRMLTEVRNIntgHMRFYY----VVGWGIPAIITGLAVGLDPQGYG-------- 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  829 ngTPDdFCWINSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRikkKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAF 908
Cdd:cd15991   135 --NPD-FCWLSVQDTLIWSFAGPIGIVVIINTVIFVLAAKASCG---RRQRYFEKSGVISMLRTAFLLLLLISATWLLGL 208
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 569011915  909 FAWGPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15991   209 MAVNSDTLSFHYLFAIFSCLQGIFIFFFHCIFNKEVRKHLKNVL 252
7tmB2_ETL cd15437
Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; ...
686-950 1.92e-26

Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; member of the class B2 family of seven-transmembrane G protein-coupled receptors; ETL (EGF-TM7-latrophilin-related protein) belongs to Group I adhesion GPCRs, which also include latrophilins (also called lectomedins or latrotoxin receptors). All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. ETL, for instance, contains EGF-like repeats, which also present in other EGF-TM7 adhesion GPCRs, such as Cadherin EGF LAG seven-pass G-type receptors (CELSR1-3), EGF-like module receptors (EMR1-3), CD97, and Flamingo. ETL is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320553 [Multi-domain]  Cd Length: 258  Bit Score: 109.58  E-value: 1.92e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  686 LTFITYIGCGLSSIFLSVTLVTYIAFEKIRRdypSKILIQLCAALLLLNLIFLLDSWIALYNTRGFCIAVAVFLHYFLLV 765
Cdd:cd15437     4 LTRITQLGIIISLICLSMCIFTFWFFSEIQS---TRTTIHKNLCCSLFLAELIFLIGINMNANKLFCSIIAGLLHYFFLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  766 SFTWMGLEAFHMYLALVKVFntYIRKYILK-FCIVGWGIPAVVVSIVLTISPDNYGIgsygkfpngtpDDFCWINSNVVF 844
Cdd:cd15437    81 AFAWMCIEGIHLYLIVVGVI--YNKGFLHKnFYIFGYGSPAVVVGISAALGYKYYGT-----------TKVCWLSTENNF 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  845 YITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQlgaQRKTSIQDLRSIA----GLTFLLGITWGFAFFAWGPVNVTFMY 920
Cdd:cd15437   148 IWSFIGPACLIILVNLLAFGVIIYKVFRHTAMLK---PEVSCYENIRSCArgalALLFLLGATWIFGVLHVVYGSVVTAY 224
                         250       260       270
                  ....*....|....*....|....*....|
gi 569011915  921 LFAIFNTLQGFFIFIFYCAAKENVRKQWRR 950
Cdd:cd15437   225 LFTISNAFQGMFIFIFLCVLSRKIQEEYYR 254
7tmB2_Latrophilin-3 cd16005
Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled ...
684-952 2.35e-26

Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320671 [Multi-domain]  Cd Length: 258  Bit Score: 109.26  E-value: 2.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  684 MALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRD----YPSKILIQLCAALLLLNLIFLLDSWIAlyntrgfCIAVAVFL 759
Cdd:cd16005     2 LLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDrntiHKNLCISLFVAELLFLIGINRTDQPIA-------CAVFAALL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  760 HYFLLVSFTWMGLEAFHMYLALVKVFNT--YIRKYilkFCIVGWGIPAVVVSIVLTISPDNYGIgsygkfpngtpDDFCW 837
Cdd:cd16005    75 HFFFLAAFTWMFLEGVQLYIMLVEVFESehSRRKY---FYLVGYGMPALIVAVSAAVDYRSYGT-----------DKVCW 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  838 INSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKK--KKQLGAQRKTSIQDLRSIAgLTFLLGITWGFAFFAWGPVN 915
Cdd:cd16005   141 LRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAilKPESGCLDNIKSWVIGAIA-LLCLLGLTWAFGLMYINEST 219
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 569011915  916 VTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd16005   220 VIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCL 256
7tmB2_Latrophilin-2 cd16006
Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled ...
684-950 2.47e-26

Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320672 [Multi-domain]  Cd Length: 258  Bit Score: 109.23  E-value: 2.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  684 MALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLdswIALYNTRGFCIAVAVFLHYFL 763
Cdd:cd16006     2 LLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIG---IDKTEYKIACPIFAGLLHFFF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  764 LVSFTWMGLEAFHMYLALVKVFNTYI--RKYilkFCIVGWGIPAVVVSIVLTISPDNYGIgsygkfpngtpDDFCWINSN 841
Cdd:cd16006    79 LAAFAWMCLEGVQLYLMLVEVFESEYsrKKY---YYVAGYLFPATVVGVSAAIDYKSYGT-----------EKACWLRVD 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  842 VVFYITVVGYFCVIFLLNVsmfIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTF----LLGITWGFAFFAWGPVNVT 917
Cdd:cd16006   145 NYFIWSFIGPVTFIILLNL---IFLVITLCKMVKHSNTLKPDSSRLENIKSWVLGAFallcLLGLTWSFGLLFINEETIV 221
                         250       260       270
                  ....*....|....*....|....*....|...
gi 569011915  918 FMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRR 950
Cdd:cd16006   222 MAYLFTIFNAFQGMFIFIFHCALQKKVRKEYSK 254
7tmB2_EMR_Adhesion_II cd15931
EGF-like module receptors, group II adhesion GPCRs, member of class B2 family of ...
752-953 5.67e-26

EGF-like module receptors, group II adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the leukocyte cell-surface antigen CD97 and the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4), are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily B2 of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying numbers of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of CD97, alternative splicing results in three isoforms possessing either three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. On the other hand, EMR2 generates four isoforms possessing either two (EGF1,2), three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. For example, CD97, which is involved in angiogenesis and the migration and invasion of tumor cells, has been shown to promote cell aggregation in a GPS proteolysis-dependent manner. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320597 [Multi-domain]  Cd Length: 262  Bit Score: 108.37  E-value: 5.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNT-YIRKYILK---FCIVGWGIPAVVVSIVLTISPDNYGIGSYgkf 827
Cdd:cd15931    67 CTVMAGLLHYLFLASFVWMLLEALQLHLLVRRLTKVqVIQRDGLPrplLCLIGYGVPFLIVGVSALVYSDGYGEAKM--- 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  828 pngtpddfCWINSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRI--KKKKQLGAQRKTSIQDLRSIAGLtFLLGITWG 905
Cdd:cd15931   144 --------CWLSQERGFNWSFLGPVIAIIGINWILFCATLWCLRQTlsNMNSDISQLKDTRLLTFKAVAQL-FILGCTWV 214
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 569011915  906 FAFFAWGPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRYLC 953
Cdd:cd15931   215 LGLFQTNPVALVFQYLFTILNSLQGAFLFLVHCLLNKEVREEYIKWLT 262
7tmB2_GPR116-like_Adhesion_VI cd15932
orphan GPR116 and related proteins, group IV adhesion GPCRs, member of the class B2 family of ...
685-945 9.04e-23

orphan GPR116 and related proteins, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group VI adhesion GPCRs consist of orphan receptors GPR110, GPR111, GPR113, GPR115, GPR116, and closely related proteins. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR110 possesses a SEA box in the N-terminal has been identified as an oncogene over-expressed in lung and prostate cancer. GPR113 contains a hormone binding domain and one EGF (epidermal grown factor) domain. GPR112 has extremely long N-terminus (about 2,400 amino acids) containing a number of Ser/Thr-rich glycosylation sites and a pentraxin (PTX) domain. GPR116 has two C2-set immunoglobulin-like repeats, which is found in the members of the immunoglobulin superfamily of cell surface proteins, and a SEA (sea urchin sperm protein, enterokinase, and a grin)-box, which is present in the extracellular domain of the transmembrane mucin (MUC) family and known to enhance O-glycosylation. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320598 [Multi-domain]  Cd Length: 268  Bit Score: 99.31  E-value: 9.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  685 ALTFITYIGCGLSSIFLSVTLVTYIAFEK-IRRDYPSKILIQLCAALLLLNLIFllDSW----IALYNTRGF---CIAVA 756
Cdd:cd15932     3 ALDYITYVGLGISILSLVLCLIIEALVWKsVTKNKTSYMRHVCLVNIALSLLIA--DIWfiigAAISTPPNPspaCTAAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  757 VFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILK--FCiVGWGIPAV--VVSIVLTISPDNYgigsygkfpngTP 832
Cdd:cd15932    81 FFIHFFYLALFFWMLTLGLLLFYRLVLVFHDMSKSTMMAiaFS-LGYGCPLIiaIITVAATAPQGGY-----------TR 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  833 DDFCWINSN-----VVFYITVVgyfcVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTS-IQDLRSIAGLTFLLGITWGF 906
Cdd:cd15932   149 KGVCWLNWDktkalLAFVIPAL----AIVVVNFIILIVVIFKLLRPSVGERPSKDEKNAlVQIGKSVAILTPLLGLTWGF 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 569011915  907 AFF-AWGPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVR 945
Cdd:cd15932   225 GLGtMIDPKSLAFHIIFAILNSFQGFFILVFGTLLDSKVR 264
7tmB2_CELSR3 cd15993
Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of ...
751-949 1.02e-22

Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuronal migration and axon guidance in the CNS. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320659 [Multi-domain]  Cd Length: 254  Bit Score: 98.76  E-value: 1.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  751 FCIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIvGWGIPAVVVSIVLTISPDNYGigsygkfpng 830
Cdd:cd15993    66 LCTVVAILLHYFFLSTFAWLFVQGLHIYRMQTEARNVNFGAMRFYYAI-GWGVPAIITGLAVGLDPEGYG---------- 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  831 TPDdFCWINSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKqlgAQRKTSIQDLRSIAGLTFLLGITWGFAFFA 910
Cdd:cd15993   135 NPD-FCWISIHDKLVWSFAGPIVVVIVMNGVMFLLVARMSCSPGQKE---TKKTSVLMTLRSSFLLLLLISATWLFGLLA 210
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 569011915  911 WGPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWR 949
Cdd:cd15993   211 VNNSVLAFHYLHAILCCLQGLAVLLLFCVLNEEVQEAWK 249
7tmB2_GPR124-like_Adhesion_III cd15259
orphan GPR124 and related proteins, group III adhesion GPCRs, member of class B2 family of ...
689-954 1.22e-22

orphan GPR124 and related proteins, group III adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group III adhesion GPCRs include orphan GPR123, GPR124, GPR125, and their closely related proteins. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. GPR123 is predominantly expressed in the CNS including thalamus, brain stem and regions containing large pyramidal cells. GPR124, also known as tumor endothelial marker 5 (TEM5), is highly expressed in tumor vessels and in the vasculature of the developing embryo. GPR124 is essentially required for proper angiogenic sprouting into neural tissue, CNS-specific vascularization, and formation of the blood-brain barrier. GPR124 also interacts with the PDZ domain of DLG1 (discs large homolog 1) through its PDZ-binding motif. Recently, studies of double-knockout mice showed that GPR124 functions as a co-activator of Wnt7a/Wnt7b-dependent beta-catenin signaling in brain endothelium. Furthermore, WNT7-stimulated beta-catenin signaling is regulated by GPR124's intracellular PDZ binding motif and leucine-rich repeats (LRR) in its N-terminal extracellular domain. GPR125 directly interacts with dishevelled (Dvl) via its intracellular C-terminus, and together, GPR125 and Dvl recruit a subset of planar cell polarity (PCP) components into membrane subdomains, a prerequisite for activation of Wnt/PCP signaling. Thus, GPR125 influences the noncanonical WNT/PCP pathway, which does not involve beta-catenin, through interacting with and modulating the distribution of Dvl.


Pssm-ID: 320387 [Multi-domain]  Cd Length: 260  Bit Score: 98.60  E-value: 1.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  689 ITYIGCGLSSIFLSVTLVTYIAFEKIRRdYPSKILIQLCAALLLLNLIFLLDSW-IALYNTRGFCIAVAVFLHYFLLVSF 767
Cdd:cd15259     7 VVYAGAALCLLCLLATIITYIVFHRLIR-ISRKGRHMLVNLCLHLLLTCVVFVGgINRTANQLVCQAVGILLHYSTLCTL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  768 TWMGLEAFHMYLALVKVFNT--------YIRKYILKFCIVGWGIPAVVVSIVLTISPDNYGIgsygkfpngtpDDFCWIN 839
Cdd:cd15259    86 LWVGVTARNMYKQVTKTAKPpqdedqppRPPKPMLRFYLIGWGIPLIICGITAAVNLDNYST-----------YDYCWLA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  840 SNV---VFYITVvgyfCVIFLLNVSMFIVVLVQLcrikkkkqlgAQRKTSIQD-LRSIAGLTFLLGITWGFAFFA---WG 912
Cdd:cd15259   155 WDPslgAFYGPA----ALIVLVNCIYFLRIYCQL----------KGAPVSFQSqLRGAVITLFLYVAMWACGALAvsqRY 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 569011915  913 PVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRylCC 954
Cdd:cd15259   221 FLDLVFSCLYGATCSSLGLFVLIHHCLSREDVRQSWRQ--CC 260
7tmB1_hormone_R cd15041
The subfamily B1 of hormone receptors (secretin-like), member of the class B family ...
683-950 5.21e-21

The subfamily B1 of hormone receptors (secretin-like), member of the class B family seven-transmembrane G protein-coupled receptors; The B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of this subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. Moreover, the B1 subfamily receptors play key roles in hormone homeostasis and are promising drug targets in various human diseases including diabetes, osteoporosis, obesity, neurodegenerative conditions (Alzheimer###s and Parkinson's), cardiovascular disease, migraine, and psychiatric disorders (anxiety, depression). Furthermore, the subfamilies B2 and B3 consist of receptors that are capable of interacting with epidermal growth factors (EGF) and the Drosophila melanogaster Methuselah gene product (Mth), respectively. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes.


Pssm-ID: 341321 [Multi-domain]  Cd Length: 273  Bit Score: 94.21  E-value: 5.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  683 MMALTFITYIGCGLSSIFLSVTLVTYIAFEKIR--RDYPSK----------ILIQLCAALLLLNLIFLLDSWIALYNTRG 750
Cdd:cd15041     1 LLVVYYIYLVGYSLSLVALLPAIVIFLYFRSLRctRIRLHInlflsfilraVFWIIWDLLVVYDRLTSSGVETVLMQNPV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  751 FCIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFnTYIRKYILKFCIVGWGIPAVVVSIvltispdnYGIGSYgkfpnG 830
Cdd:cd15041    81 GCKLLSVLKRYFKSANYFWMLCEGLYLHRLIVVAF-FSEPSSLKLYYAIGWGLPLVIVVI--------WAIVRA-----L 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  831 TPDDFCWINSNV-----VFYITVVgyFC----VIFLLNVsmfIVVLVQlcrikkkkQLGAQRKTSIQDLRSIAGLTF--- 898
Cdd:cd15041   147 LSNESCWISYNNghyewILYGPNL--LAllvnLFFLINI---LRILLT--------KLRSHPNAEPSNYRKAVKATLili 213
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011915  899 -LLGITwgFAFFAWGP-----VNVTFMYLFAIFNTLQGFFIFIFYCAA----KENVRKQWRR 950
Cdd:cd15041   214 pLFGIQ--YLLTIYRPpdgseGELVYEYFNAILNSSQGFFVAVIYCFLngevQSELKRKWSR 273
7tmB2_CELSR2 cd15992
Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of ...
752-956 1.09e-20

Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320658  Cd Length: 255  Bit Score: 92.96  E-value: 1.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTY---IRKYILkfciVGWGIPAVVVSIVLTISPDNYGigsygkfp 828
Cdd:cd15992    67 CTVIAILLHFFYLCTFSWLFLEGLHIYRMLSEVRDINygpMRFYYL----IGWGVPAFITGLAVGLDPEGYG-------- 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  829 ngTPDdFCWINsnvvFYITVVGYFC--VIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGF 906
Cdd:cd15992   135 --NPD-FCWLS----IYDTLIWSFAgpVAFAVSMNVFLYILSSRASCSAQQQSFEKKKGPVSGLRTAFTVLLLVSVTCLL 207
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 569011915  907 AFFAWGPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRryLCCGK 956
Cdd:cd15992   208 ALLSVNSDVILFHYLFAGFNCLQGPFIFLSHVVLLKEVRKALK--TLCGP 255
7tmB2_BAI_Adhesion_VII cd15251
brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 ...
692-949 5.90e-19

brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediate direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320379  Cd Length: 253  Bit Score: 87.69  E-value: 5.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  692 IGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALynTRGFCIAVAVFLHYFLLVSFTWMG 771
Cdd:cd15251    10 VGCGVSCLALLTLLAIYAAFWRYIRSERSIILINFCLSIISSNILILVGQTQTL--NKGVCTMTAAFLHFFFLSSFCWVL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  772 LEAFHMYLALV-KVFNTYIRKyilKFCIVGWGIPAVVVSIVLTIS-PDNYGIGSYgkfpngtpddfCWINSNVVFYITVV 849
Cdd:cd15251    88 TEAWQSYMAVTgRMRTRLIRK---RFLCLGWGLPALVVAVSVGFTrTKGYGTSSY-----------CWLSLEGGLLYAFV 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  850 GYFCVIFLLNVSMFIVVLVQLCrikkkkqlgaqRKTSIQDlRSIAGL------TFLLGITWGFAFFAWGPV-NVTFMYLF 922
Cdd:cd15251   154 GPAAAVVLVNMVIGILVFNKLV-----------SRDGISD-NAMASLwsscvvLPLLALTWMSAVLAMTDRrSVLFQILF 221
                         250       260
                  ....*....|....*....|....*..
gi 569011915  923 AIFNTLQGFFIFIFYCAAKENVRKQWR 949
Cdd:cd15251   222 AVFDSLQGFVIVMVHCILRREVQDAVK 248
7tmB2_BAI2 cd15988
brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 ...
692-945 6.22e-19

brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320654 [Multi-domain]  Cd Length: 291  Bit Score: 88.47  E-value: 6.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  692 IGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALynTRGFCIAVAVFLHYFLLVSFTWMG 771
Cdd:cd15988    10 IGCAVSCMALLILLAIYAAFWRFIRSERSIILLNFCLSILASNILILVGQSQTL--SKGVCTMTAAFLHFFFLSSFCWVL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  772 LEAFHMYLALV-KVFNTYIRKyilKFCIVGWGIPAVVVSIVLTIS-PDNYGIGSYgkfpngtpddfCWINSNVVFYITVV 849
Cdd:cd15988    88 TEAWQSYLAVIgRMRTRLVRK---RFLCLGWGLPALVVAVSVGFTrTKGYGTASY-----------CWLSLEGGLLYAFV 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  850 GYFCVIFLLNVSMFIVVLVQLCR------IKKKKQLGAQR--------------------------KTSIQDLRSIAGLT 897
Cdd:cd15988   154 GPAAVIVLVNMLIGIIVFNKLMSrdgisdKSKKQRAGSEAepcsslllkcskcgvvssaamssataSSAMASLWSSCVVL 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 569011915  898 FLLGITWGFAFFAWGP-VNVTFMYLFAIFNTLQGFFIFIFYCAAKENVR 945
Cdd:cd15988   234 PLLALTWMSAVLAMTDrRSILFQVLFAVFNSVQGFVIITVHCFLRREVQ 282
7tmB2_GPR113 cd15253
orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G ...
685-954 2.17e-18

orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR113 is an orphan receptor that belongs to group VI adhesion-GPCRs along with GPR110, GPR111, GPR115, and GPR116. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR113 contains a hormone binding domain and one EGF (epidermal grown factor) domain, and is primarily expressed in a subset of taste receptor cells. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320381 [Multi-domain]  Cd Length: 271  Bit Score: 86.35  E-value: 2.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  685 ALTFITYIGCGLSSIFLSVTLVTY-IAFEKIRRDYPSKILIQLCAALLLLNLIFLL----DSWIALYNTRGFCIAVAVFL 759
Cdd:cd15253     3 WLDFLSQVGLGASILALLLCLGIYrLVWRSVVRNKISYFRHMTLVNIAFSLLLADTcflgATFLSAGHESPLCLAAAFLC 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  760 HYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCI-VGWGIPAVVVSIVLTISpdnygigsygkFPNGT--PDDFC 836
Cdd:cd15253    83 HFFYLATFFWMLVQALMLFHQLLFVFHQLAKRSVLPLMVtLGYLCPLLIAAATVAYY-----------YPKRQylHEGAC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  837 WINSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIK-KKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAW-GPV 914
Cdd:cd15253   152 WLNGESGAIYAFSIPVLAIVLVNLLVLFVVLMKLMRPSvSEGPPPEERKALLSIFKALLVLTPVFGLTWGLGVATLtGES 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 569011915  915 NVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRYLCC 954
Cdd:cd15253   232 SQVSHYGFAILNAFQGVFILLFGCLMDKKVREALLKRLCK 271
7tmB1_NPR_B4_insect-like cd15260
insect neuropeptide receptor subgroup B4 and related proteins, member of the class B family of ...
752-952 8.53e-18

insect neuropeptide receptor subgroup B4 and related proteins, member of the class B family of seven-transmembrane G protein-coupled receptors; This subgroup includes a neuropeptide receptor found in Nilaparvata lugens (brown planthopper) and its closely related proteins from mollusks and annelid worms. They belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes.


Pssm-ID: 320388 [Multi-domain]  Cd Length: 267  Bit Score: 84.63  E-value: 8.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFntyIRKYILK--FCIVGWGIPAVVVSIvltispdnygigsYGKFPN 829
Cdd:cd15260    75 CQALHVLLQYFMVCNYFWMFCEGLYLHTVLVVAF---ISEKSLMrwFIAIGWGVPLVITAI-------------YAGVRA 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  830 GTPDD--FCWINSNVVFYITVVGYFC-----VIFLLNVsmfIVVLVqlcriKKKKQLGAQRKTSI--QDLRSIAGLTFLL 900
Cdd:cd15260   139 SLPDDteRCWMEESSYQWILIVPVVLsllinLIFLINI---VRVLL-----TKLRATSPNPAPAGlrKAVRATLILIPLL 210
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 569011915  901 GITWGFAFF---AWGPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15260   211 GLQFLLIPFrpePGAPLETIYQYVSALLTSLQGLCVAVLFCFCNGEVIAAIKRKW 265
7tmB2_GPR144 cd15255
orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G ...
686-950 3.69e-17

orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR144 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR133. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320383 [Multi-domain]  Cd Length: 263  Bit Score: 82.59  E-value: 3.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  686 LTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYpSKILIQLCAALLLLNLIFLLDSWIAlyNTRGFCIAVAVFLHYFLLV 765
Cdd:cd15255     4 LRTLSFIGCGVSLCALIVTFILFLAVGVPKSER-TTVHKNLIFALAAAEFLLMFSEWAK--GNQVACWAVTALLHLFFLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  766 SFTWMGLEAFHMYLALVKVFNTYIRKYILKFcIVGWGIPAVVVSIVLTISPDNYgigsygkfpngTPDDFCWINSNVVFY 845
Cdd:cd15255    81 AFSWMLVEGLLLWSKVVAVNMSEDRRMKFYY-VTGWGLPVVIVAVTLATSFNKY-----------VADQHCWLNVQTDII 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  846 ITVVGyfCVIFLLNVSMFI---VVLVQLCRIKKKKQL-----GAQRKTSIQ---DLRSIAGLTFLLGITWGFAFFAwgPV 914
Cdd:cd15255   149 WAFVG--PVLFVLTVNTFVlfrVVMVTVSSARRRAKMltpssDLEKQIGIQiwaTAKPVLVLLPVLGLTWLCGVLV--HL 224
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 569011915  915 NVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRR 950
Cdd:cd15255   225 SDVWAYVFITLNSFQGLYIFLVYAIYNSEVRNAIQR 260
7tmB2_GPR116_Ig-Hepta cd15254
The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family ...
686-938 4.43e-17

The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR116 (also known as Ig-hepta) is an orphan receptor that belongs to group VI adhesion-GPCRs along with GPR110, GPR111, GPR113, and GPR115. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR116 has four I-set immunoglobulin-like repeats, which is found in the members of the immunoglobulin superfamily of cell surface proteins, and a SEA (sea urchin sperm protein, enterokinase, and a grin)-box, which is present in the extracellular domain of the transmembrane mucin (MUC) family and known to enhance O-glycosylation. GPR116 is highly expressed in fetal and adult lung, and it has been shown to regulate lung surfactant levels as well as to stimulate breast cancer metastasis through a G(q)-p63-RhoGEF-Rho GTPase signaling pathway. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320382 [Multi-domain]  Cd Length: 275  Bit Score: 82.54  E-value: 4.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  686 LTFITYIGCGLSSIFLSVTLV----TYIAFEKIRRDYPSKILIQLCAALLLLNlifllDSWI----ALYNTR-----GFC 752
Cdd:cd15254     4 LDYITYIGLSISILSLAICIVieslVWKSVTKNRTSYMRHVCILNIAVSLLIA-----DIWFivvaAIQDQNyavngNVC 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  753 IAVAVFLHYFLLVSFTWM---GLEAFHMYLALVKVFNTYIRKYIlKFCIvGWGIPAV--VVSIVLTISPDNYgigsygkf 827
Cdd:cd15254    79 VAATFFIHFFYLCVFFWMlalGLMLFYRLVFILHDTSKTIQKAV-AFCL-GYGCPLIisVITIAVTLPRDSY-------- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  828 pngTPDDFCWIN-SNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIK-KKKQLGAQRKTSIQDLRSIAGLTFLLGITWG 905
Cdd:cd15254   149 ---TRKKVCWLNwEDSKALLAFVIPALIIVAVNSIITVVVIVKILRPSiGEKPSKQERSSLFQIIKSIGVLTPLLGLTWG 225
                         250       260       270
                  ....*....|....*....|....*....|....
gi 569011915  906 FAFFAWGP-VNVTFMYLFAIFNTLQGFFIFIFYC 938
Cdd:cd15254   226 FGLATVIKgSSIVFHILFTLLNAFQGLFILVFGT 259
7tmB2_GPR123 cd16000
G protein-coupled receptor 123, member of the class B2 family of seven-transmembrane G ...
752-954 3.14e-16

G protein-coupled receptor 123, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR123 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, and also includes orphan receptors GPR124 and GPR125. GPR123 is predominantly expressed in the CNS including thalamus, brain stem and regions containing large pyramidal cells, yet its biological function remains to be determined. Adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320666 [Multi-domain]  Cd Length: 275  Bit Score: 80.38  E-value: 3.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVK----VFNT----YIRKYILKFCIVGWGIPAVVVSIVLTISPDNYGIGS 823
Cdd:cd16000    70 CQAVGIVLHYSTLSTMLWIGVTARNIYKQVTKkphlCQDTdqppYPKQPLLRFYLVSGGVPFIICGITAATNINNYGTED 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  824 YgkfpnGTPddFCWIN---SNVVFYitvvGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLL 900
Cdd:cd16000   150 E-----DTP--YCWMAwepSLGAFY----GPVAFIVLVTCIYFLCTYVQLRRHPERKYELKNEHSFKAQLRAAAFTLFLF 218
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569011915  901 GITWGFAFFA--WGP-VNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWrrYLCC 954
Cdd:cd16000   219 TATWAFGALAvsQGHfLDMIFSCLYGAFCVTLGLFILIHHCAKRDDVWHCW--WSCC 273
7tmB1_DH_R cd15263
insect diuretic hormone receptors, member of the class B family of seven-transmembrane G ...
752-945 1.08e-14

insect diuretic hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; This group includes G protein-coupled receptors that specifically bind to insect diuretic hormones found in Manduca sexta (moth) and Acheta domesticus (the house cricket), among others. Insect diuretic hormone and their GPCRs play critical roles in the regulation of water and ion balance. Thus they are attractive targets for developing new insecticides. Activation of the diuretic hormone receptors stimulate adenylate cyclase, thereby increasing cAMP levels in Malpighian tube. They belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of Gs family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx.


Pssm-ID: 320391 [Multi-domain]  Cd Length: 272  Bit Score: 75.48  E-value: 1.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIvGWGIPAVVVSIVLTISPDNYGIGSYGKFPNGT 831
Cdd:cd15263    71 CIILVVLLHYFHLTNFFWMFVEGLYLYMLVVETFSGENIKLRVYAFI-GWGIPAVVIVIWAIVKALAPTAPNTALDPNGL 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  832 PDDFCWINSNVV--FYITVVgyfCVIFLLNV---SMFIVVLVQLCRIKKKKQLGAQRKTSiqdlRSIAGLTFLLGITwgF 906
Cdd:cd15263   150 LKHCPWMAEHIVdwIFQGPA---ILVLAVNLvflVRIMWVLITKLRSANTVETQQYRKAA----KALLVLIPLLGIT--Y 220
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 569011915  907 AFFAWGP----VNVTFMYLFAIFNTLQGFFIFIFYCAAKENVR 945
Cdd:cd15263   221 ILVIAGPtegiAANIFEYVRAVLLSTQGFTVALFYCFLNTEVR 263
7tmB2_BAI1 cd15990
brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 ...
692-946 1.09e-14

brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320656  Cd Length: 267  Bit Score: 75.41  E-value: 1.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  692 IGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIAlyNTRGFCIAVAVFLHYFLLVSFTWMG 771
Cdd:cd15990    13 VGCGVSSLTLLLLIIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQT--RNKVVCTLVAAFLHFFFLSSFCWVL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  772 LEAFHMYLALV-KVFNTYIRKyilKFCIVGWGIPAVVVSIVLTISPDNygigSYGKFpngtpdDFCWINSNVVFYITVVG 850
Cdd:cd15990    91 TEAWQSYMAVTgRLRNRIIRK---RFLCLGWGLPALVVAISVGFTKAK----GYGTV------NYCWLSLEGGLLYAFVG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  851 YFCVIFLLNVSMFIVVLVQLCR------IKKKKQLGAQRKTSIQDLRsiagltfLLGITWGFAFFAWGP-VNVTFMYLFA 923
Cdd:cd15990   158 PAAAVVLVNMVIGILVFNKLVSkdgitdKKLKERAGASLWSSCVVLP-------LLALTWMSAVLAITDrRSALFQILFA 230
                         250       260
                  ....*....|....*....|...
gi 569011915  924 IFNTLQGFFIFIFYCAAKENVRK 946
Cdd:cd15990   231 VFDSLEGFVIVMVHCILRREVQD 253
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
619-670 3.33e-13

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


Pssm-ID: 460350  Cd Length: 44  Bit Score: 64.64  E-value: 3.33e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 569011915   619 VKCVFWDLGRNdtalvptgGKGGWSSDGCSVKDKRMNETICTCSHLTSFGIL 670
Cdd:pfam01825    1 PQCVFWDFTNS--------TTGRWSTEGCTTVSLNDTHTVCSCNHLTSFAVL 44
7tmB1_PACAP-R1 cd15987
pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B ...
752-949 5.92e-13

pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PACAP-R1) is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, growth-hormone-releasing hormone (GHRH), and vasoactive intestinal peptide (VIP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. VIP and PACAP exert their effects through three G protein-coupled receptors, PACAP-R1, VIP-R1 (vasoactive intestinal receptor type 1, also known as VPAC1) and VIP-R2 (or VPAC2). PACAP-R1 binds only PACAP with high affinity, whereas VIP-R1 and -R2 specifically bind and respond to both VIP and PACAP. VIP and PACAP and their receptors are widely expressed in the brain and periphery. They are upregulated in neurons and immune cells in responses to CNS injury and/or inflammation and exert potent anti-inflammatory effects, as well as play important roles in the control of circadian rhythms and stress responses, among many others. PACAP-R1 is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level.


Pssm-ID: 320653 [Multi-domain]  Cd Length: 268  Bit Score: 70.38  E-value: 5.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYiRKYILKFCIVGWGIPAVVVSI--VLTISPDNYGigsygkfpn 829
Cdd:cd15987    77 CKAVMVFFHYCVMSNYFWLFIEGLYLFTLLVETFFPE-RRYFYWYTIIGWGTPTICVTVwaVLRLHFDDTG--------- 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  830 gtpddfCW-INSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKT-SIQDLRSIAGLTFLLGITwgFA 907
Cdd:cd15987   147 ------CWdMNDNTALWWVIKGPVVGSIMINFVLFIGIIIILVQKLQSPDIGGNESSiYLRLARSTLLLIPLFGIH--YT 218
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 569011915  908 FFAWGPVNVTF--MYLFAI-FNTLQGFFIFIFYC----AAKENVRKQWR 949
Cdd:cd15987   219 VFAFSPENVSKreRLVFELgLGSFQGFVVAVLYCflngEVQSEIKRKWR 267
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
618-675 1.19e-12

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 63.18  E-value: 1.19e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 569011915    618 TVKCVFWDLGRndtalvptggkGGWSSDGCSVKDKRMNETICTCSHLTSFGILLDLSR 675
Cdd:smart00303    2 NPICVFWDESS-----------GEWSTRGCELLETNGTHTTCSCNHLTTFAVLMDVPP 48
7tmB1_CRF-R cd15264
corticotropin-releasing factor receptors, member of the class B family of seven-transmembrane ...
689-950 4.23e-12

corticotropin-releasing factor receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; The vertebrate corticotropin-releasing factor (CRF) receptors are predominantly expressed in central nervous system with high levels in cortex tissue, brain stem, and pituitary. They have two isoforms as a result of alternative splicing of the same receptor gene: CRF-R1 and CRF-R2, which differ in tissue distribution and ligand binding affinities. Recently, a third CRF receptor (CRF-R3) has been identified in catfish pituitary. The catfish CRF-R1 is highly homologous to CRF-R3. CRF is a 41-amino acid neuropeptide that plays a central role in coordinating neuroendocrine, behavioral, and autonomic responses to stress by acting as the primary neuroregulator of the hypothalamic-pituitary-adrenal axis, which controls the levels of cortisol and other stress related hormones. In addition, the CRF family of neuropeptides also includes structurally related peptides such as mammalian urocortin, fish urotensin I, and frog sauvagine. The actions of CRF and CRF-related peptides are mediated through specific binding to CRF-R1 and CRF-R2. CRF and urocortin 1 bind and activate mammalian CRF-R1 with similar high affinities. By contrast, urocortin 2 and urocortin 3 do not bind to CRF-R1 or stimulate CRF-R1-mediated cAMP formation. Urocortin 1 also shows high affinity for mammalian CRF-R2, whereas CRF has significantly lower affinity for this receptor. These evidence suggest that urocortin 1 is an endogenous ligand for CRF-R1 and CRF-R2. The CRF receptors are members of the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, and parathyroid hormone (PTH). These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on its cellular location and function, CRF receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320392 [Multi-domain]  Cd Length: 265  Bit Score: 67.83  E-value: 4.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  689 ITYIGCGLSSIFLSVTLVTYIAFEKIRrdypskILIQLCAALLLLNLIFLLDSWIALYNT---------RGFC-IAVAVF 758
Cdd:cd15264     7 IYYLGFSISLVALAVALIIFLYFRSLR------CLRNNIHCNLIVTFILRNVTWFIMQNTlteihhqsnQWVCrLIVTVY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  759 lHYFLLVSFTWMGLEAFHMYLALVKVFNT-YIRKYIlkFCIVGWGIPAVVVsIVLTISPdNYGIGSYGKFPNGTPDDFCW 837
Cdd:cd15264    81 -NYFQVTNFFWMFVEGLYLHTMIVWAYSAdKIRFWY--YIVIGWCIPCPFV-LAWAIVK-LLYENEHCWLPKSENSYYDY 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  838 INSNVVFYITVVGyfcVIFLLNVsmfIVVLVQLCRIKKKKQLGAQRKTsiqdLRSIAGLTFLLGITWGFAFFAWGP---V 914
Cdd:cd15264   156 IYQGPILLVLLIN---FIFLFNI---VWVLITKLRASNTLETIQYRKA----VKATLVLLPLLGITYMLFFINPGDdktS 225
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 569011915  915 NVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRR 950
Cdd:cd15264   226 RLVFIYFNTFLQSFQGLFVAVFYCFLNGEVRSAIRK 261
7tmB1_CRF-R1 cd15445
corticotropin-releasing factor receptor 1, member of the class B family of seven-transmembrane ...
750-950 7.83e-12

corticotropin-releasing factor receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors; The vertebrate corticotropin-releasing factor (CRF) receptors are predominantly expressed in central nervous system with high levels in cortex tissue, brain stem, and pituitary. They have two isoforms as a result of alternative splicing of the same receptor gene: CRF-R1 and CRF-R2, which differ in tissue distribution and ligand binding affinities. Recently, a third CRF receptor (CRF-R3) has been identified in catfish pituitary. The catfish CRF-R1 is highly homologous to CRF-R3. CRF is a 41-amino acid neuropeptide that plays a central role in coordinating neuroendocrine, behavioral, and autonomic responses to stress by acting as the primary neuroregulator of the hypothalamic-pituitary-adrenal axis, which controls the levels of cortisol and other stress related hormones. In addition, the CRF family of neuropeptides also includes structurally related peptides such as mammalian urocortin, fish urotensin I, and frog sauvagine. The actions of CRF and CRF-related peptides are mediated through specific binding to CRF-R1 and CRF-R2. CRF and urocortin 1 bind and activate mammalian CRF-R1 with similar high affinities. By contrast, urocortin 2 and urocortin 3 do not bind to CRF-R1 or stimulate CRF-R1-mediated cAMP formation. Urocortin 1 also shows high affinity for mammalian CRF-R2, whereas CRF has significantly lower affinity for this receptor. These evidence suggest that urocortin 1 is an endogenous ligand for CRF-R1 and CRF-R2. The CRF receptors are members of the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, and parathyroid hormone (PTH). These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on its cellular location and function, CRF receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320561 [Multi-domain]  Cd Length: 265  Bit Score: 66.88  E-value: 7.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  750 GFCIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNT-YIRKYIlkFCIVGWGIPAVVVsIVLTISPDNYGigsygkfp 828
Cdd:cd15445    71 VWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTdKLRKWM--FICIGWCIPFPII-VAWAIGKLYYD-------- 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  829 ngtpDDFCWINSNVVFYITVV--GYFCVIFLLNvsmfIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAG---LTFLLGIT 903
Cdd:cd15445   140 ----NEKCWFGKRAGVYTDYIyqGPMILVLLIN----FIFLFNIVRILMTKLRASTTSETIQYRKAVKAtlvLLPLLGIT 211
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 569011915  904 WGFAFFAWGPVNVT---FMYLFAIFNTLQGFFIFIFYC----AAKENVRKQWRR 950
Cdd:cd15445   212 YMLFFVNPGEDEISrivFIYFNSFLESFQGFFVSVFYCflnsEVRSAVRKRWHR 265
7tmB1_Secretin_R-like cd15930
secretin receptor-like group of hormone receptors, member of the class B family of ...
752-950 9.51e-12

secretin receptor-like group of hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; This group represents G protein-coupled receptors for structurally similar peptide hormones that include secretin, growth-hormone-releasing hormone (GHRH), pituitary adenylate cyclase activating polypeptide (PACAP), and vasoactive intestinal peptide (VIP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. Secretin, a polypeptide secreted by entero-endocrine S cells in the small intestine, is involved in maintaining body fluid balance. This polypeptide regulates the secretion of bile and bicarbonate into the duodenum from the pancreatic and biliary ducts, as well as regulates the duodenal pH by the control of gastric acid secretion. Studies with secretin receptor-null mice indicate that secretin plays a role in regulating renal water reabsorption. Secretin mediates its biological actions by elevating intracellular cAMP via G protein-coupled secretin receptors, which are expressed in the brain, pancreas, stomach, kidney, and liver. GHRHR is a specific receptor for the growth hormone-releasing hormone (GHRH) that controls the synthesis and release of growth hormone (GH) from the anterior pituitary somatotrophs. Mutations in the gene encoding GHRHR have been connected to isolated growth hormone deficiency (IGHD), a short-stature condition caused by deficient production of GH or lack of GH action. VIP and PACAP exert their effects through three G protein-coupled receptors, PACAP-R1, VIP-R1 (vasoactive intestinal receptor type 1, also known as VPAC1) and VIP-R2 (or VPAC2). PACAP-R1 binds only PACAP with high affinity, whereas VIP-R1 and -R2 specifically bind and respond to both VIP and PACAP. VIP and PACAP and their receptors are widely expressed in the brain and periphery. They are upregulated in neurons and immune cells in responses to CNS injury and/or inflammation and exert potent anti-inflammatory effects, as well as play important roles in the control of circadian rhythms and stress responses, among many others. All B1 subfamily GPCRs are able to increase intracellular cAMP levels by coupling to adenylate cyclase via a stimulatory Gs protein. However, depending on its cellular location, some members of subfamily B1 are also capable of coupling to additional G proteins such as G(i/o) and/or G(q) proteins, thereby leading to activation of phospholipase C and intracellular calcium influx.


Pssm-ID: 320596 [Multi-domain]  Cd Length: 268  Bit Score: 66.69  E-value: 9.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFnTYIRKYILKFCIVGWGIPAVVVS--IVLTISPDNYGigsygkfpn 829
Cdd:cd15930    77 CKASMVFFQYCVMANFFWLLVEGLYLHTLLVISF-FSERRYFWWYVLIGWGAPTVFVTvwIVARLYFEDTG--------- 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  830 gtpddfCW-INSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDL-RSIAGLTFLLGITwgFA 907
Cdd:cd15930   147 ------CWdINDESPYWWIIKGPILISILVNFVLFINIIRILLQKLRSPDIGGNESSQYKRLaRSTLLLIPLFGIH--YI 218
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 569011915  908 FFAWGPVNVTF---MYLFAIFNTLQGFFIFIFYC----AAKENVRKQWRR 950
Cdd:cd15930   219 VFAFFPENISLgirLYFELCLGSFQGFVVAVLYCflngEVQAEIKRKWRS 268
7tmB2_BAI3 cd15989
brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 ...
747-949 1.10e-11

brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320655 [Multi-domain]  Cd Length: 293  Bit Score: 67.02  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  747 NTRGFCIAVAVFLHYFLLVSFTWMGLEAFHMYLALV-KVFNTYIRKyilKFCIVGWGIPAVVVSIVLTISPDNygigSYG 825
Cdd:cd15989    65 HNKGICTMTTAFLHFFFLASFCWVLTEAWQSYMAVTgKIRTRLIRK---RFLCLGWGLPALVVAISMGFTKAK----GYG 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  826 KfpngtpDDFCWINSNVVFYITVVGYFCVIFLLNVSMFIVVLVQL-------------------------------CRIK 874
Cdd:cd15989   138 T------PHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLvsrdgildkklkhragqmsephsgltlkcakCGVV 211
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569011915  875 KKKQLGAQRKT-SIQDLRSIAGLTFLLGITWGFAFFAW-GPVNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWR 949
Cdd:cd15989   212 STTALSATTASnAMASLWSSCVVLPLLALTWMSAVLAMtDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAFR 288
7tmB1_CRF-R2 cd15446
corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane ...
751-950 2.29e-11

corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors; The vertebrate corticotropin-releasing factor (CRF) receptors are predominantly expressed in central nervous system with high levels in cortex tissue, brain stem, and pituitary. They have two isoforms as a result of alternative splicing of the same receptor gene: CRF-R1 and CRF-R2, which differ in tissue distribution and ligand binding affinities. Recently, a third CRF receptor (CRF-R3) has been identified in catfish pituitary. The catfish CRF-R1 is highly homologous to CRF-R3. CRF is a 41-amino acid neuropeptide that plays a central role in coordinating neuroendocrine, behavioral, and autonomic responses to stress by acting as the primary neuroregulator of the hypothalamic-pituitary-adrenal axis, which controls the levels of cortisol and other stress related hormones. In addition, the CRF family of neuropeptides also includes structurally related peptides such as mammalian urocortin, fish urotensin I, and frog sauvagine. The actions of CRF and CRF-related peptides are mediated through specific binding to CRF-R1 and CRF-R2. CRF and urocortin 1 bind and activate mammalian CRF-R1 with similar high affinities. By contrast, urocortin 2 and urocortin 3 do not bind to CRF-R1 or stimulate CRF-R1-mediated cAMP formation. Urocortin 1 also shows high affinity for mammalian CRF-R2, whereas CRF has significantly lower affinity for this receptor. These evidence suggest that urocortin 1 is an endogenous ligand for CRF-R1 and CRF-R2. The CRF receptors are members of the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, and parathyroid hormone (PTH). These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on its cellular location and function, CRF receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320562 [Multi-domain]  Cd Length: 264  Bit Score: 65.37  E-value: 2.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  751 FCIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNT-YIRKYIlkFCIVGWGIPAVVVsIVLTISPDNYgigsygkfpn 829
Cdd:cd15446    71 WCRCITTIYNYFVVTNFFWMFVEGCYLHTAIVMTYSTdKLRKWV--FLFIGWCIPCPII-VAWAIGKLYY---------- 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  830 gtPDDFCWINSNVVFYITVVGYFCVIFLLNVSMfiVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAG---LTFLLGITWGF 906
Cdd:cd15446   138 --ENEQCWFGKEPGKYIDYIYQGPVILVLLINF--VFLFNIVRILMTKLRASTTSETIQYRKAVKAtlvLLPLLGITYML 213
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569011915  907 AFFAWGPVNVT---FMYLFAIFNTLQGFFIFIFYC----AAKENVRKQWRR 950
Cdd:cd15446   214 FFVNPGEDDISqivFIYFNSFLQSFQGFFVSVFYCflngEVRSAARKRWHR 264
7tmB2_GPR111_115 cd15994
orphan adhesion receptors GPR111 and GPR115, member of the class B2 family of ...
752-936 5.37e-11

orphan adhesion receptors GPR111 and GPR115, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR111 and GPR115 are highly homologous orphan receptors that belong to group VI adhesion-GPCRs along with GPR110, GPR113, and GPR116. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS. Both GPR111 and GPR5 are present only in land-living animals and are predominantly expressed in the developing skin.


Pssm-ID: 320660 [Multi-domain]  Cd Length: 267  Bit Score: 64.47  E-value: 5.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIR-KYILKFCIVGWGIPAVVVSIVLTISPDNYGIGSYGKfpng 830
Cdd:cd15994    76 CVAATFFLHFFYLSLFFWMLTKALLILYGILLVFFKITKsVFIATAFSIGYGCPLVIAVLTVAITEPKKGYLRPEA---- 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  831 tpddfCWIN-SNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFF 909
Cdd:cd15994   152 -----CWLNwDETKALLAFIIPALSIVVVNLIVVGVVVVKTQRSSIGESCKQDVSNIIRISKNVAILTPLLGLTWGFGLA 226
                         170       180
                  ....*....|....*....|....*...
gi 569011915  910 AW-GPVNVTFMYLFAIFNTLQGFFIFIF 936
Cdd:cd15994   227 TIiDSRSLPFHIIFALLNAFQGFFILLF 254
7tmB1_PTH1R cd15984
parathyroid hormone 1 receptor, member of the class B family of seven-transmembrane G ...
752-950 1.55e-10

parathyroid hormone 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; The parathyroid hormone (PTH) receptor family has three subtypes: PTH1R, PTH2R and PTH3R. PTH1R is expressed in bone and kidney and is activated by two polypeptide ligands: PTH, an endocrine hormone that regulates calcium homoeostasis and bone maintenance, and PTH-related peptide (PTHrP), a paracrine factor that regulates endochondral bone development. PTH1R couples predominantly to G(s)-protein that in turn activates adenylate cyclase thereby producing cAMP, but it can also couple to several G protein subtypes, including G(q/11), G(i/o), and G(12/13), resulting in activation of multiple intracellular signaling pathways. PTH1R is found in all vertebrate species, whereas PTH2R is found in mammals and fish, but not in chicken or frog. PTH3R is found in chicken and fish, but it is absent in mammals. The PTH receptors are members of the B1 (or secretin-like) subfamily of class B GPCRs, which include receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), and calcitonin gene-related peptide. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways.


Pssm-ID: 320650 [Multi-domain]  Cd Length: 290  Bit Score: 63.43  E-value: 1.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYiRKYILKFCIVGWGIPAVVVSIVLTISPDnygigsygkfpngT 831
Cdd:cd15984    95 CKVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSE-KKYLWGFTLFGWGLPAVFVTIWASVRAT-------------L 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  832 PDDFCW-INSNVVFYITVVGYFCVIfLLNVSMFIVVLVQLCriKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWG----- 905
Cdd:cd15984   161 ADTGCWdLSAGNLKWIIQVPILAAI-VVNFILFINIVRVLA--TKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGvhyiv 237
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569011915  906 FAFFAWGPVNVTF----MYLFAIFNTLQGFFIFIFYC----AAKENVRKQWRR 950
Cdd:cd15984   238 FMAMPYTEVSGILwqvqMHYEMLFNSFQGFFVAIIYCfcngEVQAEIKKSWSR 290
7tmB1_GHRHR2 cd15271
growth-hormone-releasing hormone receptor type 2, member of the class B family of ...
752-953 1.75e-10

growth-hormone-releasing hormone receptor type 2, member of the class B family of seven-transmembrane G protein-coupled receptors; Growth hormone-releasing hormone receptor type 2 (GHRHR2) is found in non-mammalian vertebrates such as chicken and frog. It is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, pituitary adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal peptide, and mammalian growth hormone-releasing hormone. These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. Mammalian GHRHR is a specific receptor for the growth hormone-releasing hormone (GHRH) that controls the synthesis and release of growth hormone (GH) from the anterior pituitary somatotrophs. Mutations in the gene encoding GHRHR have been connected to isolated growth hormone deficiency (IGHD), a short-stature condition caused by deficient production of GH or lack of GH action. Mammalian GHRH is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level. GHRHR is found in mammals as well as zebrafish and chicken, whereas the GHRHR type 2, an ortholog of the GHRHR, has only been identified in ray-finned fish, chicken and Xenopus. Xenopus laevis GHRHR2 has been shown to interact with both endogenous GHRH and PACAP-related peptide (PRP).


Pssm-ID: 320399 [Multi-domain]  Cd Length: 267  Bit Score: 62.83  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFnTYIRKYILKFCIVGWGIPAVVVSI-VLT-ISPDNYGigsygkfpn 829
Cdd:cd15271    77 CKAAVTFFQFCVLANFFWLLVEGMYLQTLLLLTF-TSDRKYFWWYILIGWGAPSVTVTVwVLTrLQYDNRG--------- 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  830 gtpddfCWINSNVVFYITVVGYFCVIFLLNVSMFIVV---LVQlcRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWG- 905
Cdd:cd15271   147 ------CWDDLESRIWWIIKTPILLSVFVNFLIFINViriLVQ--KLKSPDVGGNDTSHYMRLAKSTLLLIPLFGVHYVv 218
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569011915  906 FAFFawgPVNVTF---MYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRYLC 953
Cdd:cd15271   219 FAFF---PEHVGVearLYFELVLGSFQGFIVALLYCFLNGEVQAEIKKRLG 266
7tmB1_PDFR cd15261
The pigment dispersing factor receptor, member of the class B seven-transmembrane G ...
741-950 3.24e-10

The pigment dispersing factor receptor, member of the class B seven-transmembrane G protein-coupled receptors; The pigment dispersing factor receptor (PDFR) is a G protein-coupled receptor that binds the circadian clock neuropeptide PDF, a functional ortholog of the mammalian vasoactive intestinal peptide (VIP), on the pacemaker neurons. The PDFR is implicated in regulating flight circuit development and in modulating acute flight In Drosophila melanogaster. The PDFR activation stimulates adenylate cyclase, thereby increasing cAMP levels in many different pacemakers, and the receptor signaling has been shown to regulate behavioral circadian rhythms and geotaxis in Drosophila. The PDFR belongs to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. . These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. They play key roles in hormone homeostasis in mammals and are promising drug targets in various human diseases including diabetes, osteoporosis, obesity, neurodegenerative conditions (Alzheimer###s and Parkinson's), cardiovascular disease, migraine, and psychiatric disorders (anxiety, depression).


Pssm-ID: 320389 [Multi-domain]  Cd Length: 282  Bit Score: 62.38  E-value: 3.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  741 SWIALYNTRGFCIAVAVFLHYFLLVSFTWMGLEAFHMY-LALVKVFNTyiRKYILKFCIVGWGIPAVVVSIVLTISPDNY 819
Cdd:cd15261    77 EGRTINSTPILCEGFYVLLEYAKTVMFMWMFIEGLYLHnIIVVSVFSG--KPNYLFYYILGWGIPIVHTSAWAIVTLIKM 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  820 GIGSYGKFPNGTPddFCWINSNVVFYITVVGYFcviFLLNVsmfIVVLVQLCRIKKKKQLGAQRKTsiqdLRSIAGLTFL 899
Cdd:cd15261   155 KVNRCWFGYYLTP--YYWILEGPRLAVILINLF---FLLNI---IRVLVSKLRESHSREIEQVRKA----VKAAIVLLPL 222
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011915  900 LGIT--------------WGFAFFAWGpvnVTFMYLFaifntlQGFFIFIFYCAAKENVR----KQWRR 950
Cdd:cd15261   223 LGITnilqmipppltsviVGFAVWSYS---THFLTSF------QGFFVALIYCFLNGEVKnvlkKFWRR 282
7tmB1_NPR_B7_insect-like cd15273
insect neuropeptide receptor subgroup B7 and related proteins, member of the class B family of ...
743-952 2.00e-09

insect neuropeptide receptor subgroup B7 and related proteins, member of the class B family of seven-transmembrane G protein-coupled receptors; This subgroup includes a neuropeptide receptor found in Nilaparvata lugens (brown planthopper) and its closely related proteins from invertebrates. They belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes.


Pssm-ID: 320401 [Multi-domain]  Cd Length: 285  Bit Score: 60.08  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  743 IALYNTRGFCIAVAVFLHYFLLVSFTWMGLEAFHMY-LALVKVF--NTYIRKYIlkfcIVGWGIPAVVVS--IVLTISPD 817
Cdd:cd15273    82 IANIGSNWVCKAITSLWQYFIIANYSWILMEGLYLHnLIFLALFsdENNIILYI----LLGWGLPLIFVVpwIVARILFE 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  818 NygigsygkfpngtpdDFCWI-NSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLcrIKKKKQLGAQRKTSIQDL-RSIAG 895
Cdd:cd15273   158 N---------------SLCWTtNSNLLNFLIIRIPIMISVLINFILFLNIVRVL--LVKLRSSVNEDSRRYKKWaKSTLV 220
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011915  896 LTFLLGITW----GFAFFAWGPVNVTFMYLF--AIFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15273   221 LVPLFGVHYtiflILSYLDDTNEAVELIWLFcdQLFASFQGFFVALLYCFLNGEVRAEIQRKW 283
7tmB1_GLP2R cd15266
glucagon-like peptide-2 receptor, member of the class B family of seven-transmembrane G ...
740-950 3.31e-09

glucagon-like peptide-2 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Glucagon-like peptide-2 receptor (GLP2R) is a member of the glucagon receptor family of G protein-coupled receptors, which also includes glucagon receptor (GCGR) and GLP1R. GLP2R is activated by glucagon-like peptide 2, which is derived from the large proglucagon precursor. Activation of GLP1R stimulates glucose-dependent insulin secretion from pancreatic beta cells, whereas activation of GLP2R stimulates intestinal epithelial proliferation and increases villus height in the small intestine. GCGR regulates blood glucose levels by control of hepatic glycogenolysis and gluconeogenesis and by regulation of insulin secretion from the pancreatic beta-cells. GLP2R belongs to the B1 (or secretin-like) subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on their cellular location, GCGR and GLP receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320394 [Multi-domain]  Cd Length: 280  Bit Score: 59.37  E-value: 3.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  740 DSWIALYN--TRGFCIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYiRKYILKFCIVGWGIPA--VVVSIVLTIS 815
Cdd:cd15266    73 TGWISYLSeeSSTSCRVAQVFMHYFVGANYFWLLVEGLYLHTLLVTAVLSE-RRLLKKYMLIGWGTPVlfVVPWGVAKIL 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  816 PDNYGigsygkfpngtpddfCW-INSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLgAQRKTSIQDLRSIA 894
Cdd:cd15266   152 LENTG---------------CWgRNENMGIWWIIRGPILLCITVNFYIFLKILKLLLSKLKAQQM-RFTDYKYRLARSTL 215
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011915  895 GLTFLLGI------------TWGFAFFAWGPVNVTfmylfaiFNTLQGFFIFIFYCAA----KENVRKQWRR 950
Cdd:cd15266   216 VLIPLLGIhevvfsfitdeqVEGFSRHIRLFIQLT-------LSSFQGFLVAVLYCFAngevKAELKKRWQL 280
7tmB1_VIP-R1 cd15269
vasoactive intestinal polypeptide (VIP) receptor 1, member of the class B family of ...
752-950 4.37e-09

vasoactive intestinal polypeptide (VIP) receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors; Vasoactive intestinal peptide (VIP) receptor 1 is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, growth-hormone-releasing hormone (GHRH), and pituitary adenylate cyclase activating polypeptide (PACAP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. VIP and PACAP exert their effects through three G protein-coupled receptors, PACAP-R1, VIP-R1 (vasoactive intestinal receptor type 1, also known as VPAC1) and VIP-R2 (or VPAC2). PACAP-R1 binds only PACAP with high affinity, whereas VIP-R1 and -R2 specifically bind and respond to both VIP and PACAP. VIP and PACAP and their receptors are widely expressed in the brain and periphery. They are upregulated in neurons and immune cells in responses to CNS injury and/or inflammation and exert potent anti-inflammatory effects, as well as play important roles in the control of circadian rhythms and stress responses, among many others. VIP-R1 is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level. However, depending on its cellular location, VIP-R1 is also capable of coupling to additional G proteins such as G(q) protein, thus leading to the activation of phospholipase C and intracellular calcium influx.


Pssm-ID: 320397 [Multi-domain]  Cd Length: 268  Bit Score: 58.71  E-value: 4.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYiRKYILKFCIVGWGIPAVVVSI--VLTISPDNYGigsygkfpn 829
Cdd:cd15269    77 CKAAMVFFQYCIMANFFWLLVEGLYLHTLLAVSFFSE-RKYFWWYILIGWGAPSVFITAwsVARIYFEDVG--------- 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  830 gtpddfCW--INSNVVFYITVVGYFCVIfLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDL-RSIAGLTFLLGITwgF 906
Cdd:cd15269   147 ------CWdtIIESLLWWIIKTPILVSI-LVNFILFICIIRILVQKLHSPDIGRNESSQYSRLaKSTLLLIPLFGIH--Y 217
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569011915  907 AFFAWGPVNVTF---MYLFAIFNTLQGFFIFIFYC----AAKENVRKQWRR 950
Cdd:cd15269   218 IMFAFFPDNFKAevkLVFELILGSFQGFVVAVLYCflngEVQAELKRKWRR 268
7tmB1_PTH2R cd15982
parathyroid hormone 2 receptor, member of the class B family of seven-transmembrane G ...
753-950 1.60e-08

parathyroid hormone 2 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; The parathyroid hormone 2 receptor (PTH2R), one of the three subtypes of PTH receptor family, is found in mammals and fish, but not in chicken or frog. PTH2R is potently activated by tuberoinfundibular peptide-39 (TIP-39) but not by PTH-related peptide (PTHrP), a paracrine factor that regulates endochondral bone development. PTH, an endocrine hormone that regulates calcium homoeostasis and bone maintenance, strongly activates human PTH2R, but only weakly activates rat and zebrafish PTH2Rs. These results suggest that TIP-39 is a natural ligand for PTH2R. Conversely, PTH1R is activated by PTH and PTHrP, but not by TIP-39. The PTH family receptors are members of the B1 (or secretin-like) subfamily of class B GPCRs, which include receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), and calcitonin gene-related peptide. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways.


Pssm-ID: 320648 [Multi-domain]  Cd Length: 289  Bit Score: 57.25  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  753 IAVAVFLhYFLLVSFTWMGLEAFHMY-LALVKVFNTyiRKYILKFCIVGWGIPAVVVSIVLTISPDnygigsygkfpngT 831
Cdd:cd15982    97 IAVVMFI-YFLATNYYWILVEGLYLHsLIFVAFFSD--TKYLWGFTLIGWGFPAVFVAAWAVVRAT-------------L 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  832 PDDFCW-INSNVVFYITVVGYFCVIFLlNVSMFI-VVLVQLCRIKKKKQLGAQRKtsiQDLRSIAGLTFLLGITWGFAFF 909
Cdd:cd15982   161 ADARCWeLSAGDIKWIYQAPILAAIGL-NFILFLnTVRVLATKIWETNAVGYDTR---KQYRKLAKSTLVLVLVFGVHYI 236
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569011915  910 AWGPVNVTF--------MYLFAIFNTLQGFFIFIFYC----AAKENVRKQWRR 950
Cdd:cd15982   237 VFVCLPHTFtglgweirMHCELFFNSFQGFFVSIIYCycngEVQTEIKKTWTR 289
7tmB2_GPR124 cd15998
G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G ...
743-954 2.45e-08

G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR124 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, which also includes orphan GPR123 and GPR125. GPR124, also known as tumor endothelial marker 5 (TEM5), is highly expressed in tumor vessels and in the vasculature of the developing embryo. GPR124 is essentially required for proper angiogenic sprouting into neural tissue, CNS-specific vascularization, and formation of the blood-brain barrier. GPR124 interacts with the PDZ domain of DLG1 (discs large homolog 1) through its PDZ-binding motif. Recently, studies of double-knockout mice showed that GPR124 functions as a co-activator of Wnt7a/Wnt7b-dependent beta-catenin signaling in brain endothelium. Moreover, WNT7-stimulated beta-catenin signaling is regulated by GPR124's intracellular PDZ binding motif and leucine-rich repeats (LRR) in its N-terminal extracellular domain. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320664 [Multi-domain]  Cd Length: 268  Bit Score: 56.50  E-value: 2.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  743 IALYNTRGFCIAVAVFLHYFLLVSFTWMGLEAFHMYLALV---------KVFNTYIRKyILKFCIVGWGIPAVVVSIVLT 813
Cdd:cd15998    61 ITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTwrapppqegDPALPTPRP-MLRFYLIAGGIPLIICGITAA 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  814 ISPDNYgigsygkfPNGTPddFCWI---NSNVVFYITVVgyfcVIFLLNVSMFIVVLVQL-CRIKKKKQLGAQRktsiQD 889
Cdd:cd15998   140 VNIHNY--------RDHSP--YCWLvwrPSLGAFYIPVA----LILLVTWIYFLCAGLHLrGPSADGDSVYSPG----VQ 201
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011915  890 LRSIAGLTFLLGITWGFAFFA----WGPvNVTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWRRylCC 954
Cdd:cd15998   202 LGALVTTHFLYLAMWACGALAvsqrWLP-RVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRA--CC 267
7tmB1_GLP1R cd15268
glucagon-like peptide-1 receptor, member of the class B family of seven-transmembrane G ...
752-950 4.63e-07

glucagon-like peptide-1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Glucagon-like peptide-1 receptor (GLP1R) is a member of the glucagon receptor family of G protein-coupled receptors, which also includes glucagon receptor and GLP2R. GLP1R is activated by glucagon-like peptide 1 (GLP1), which is derived from the large proglucagon precursor. Activation of GLP1R stimulates glucose-dependent insulin secretion from pancreatic beta cells, whereas activation of GLP2R stimulates intestinal epithelial proliferation and increases villus height in the small intestine. GCGR regulates blood glucose levels by control of hepatic glycogenolysis and gluconeogenesis and by regulation of insulin secretion from the pancreatic beta-cells. Receptors in this group belong to the B1 (or secretin-like) subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on their cellular location, GCGR and GLP receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 341342 [Multi-domain]  Cd Length: 279  Bit Score: 52.65  E-value: 4.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVkvFNTYIRKYILK-FCIVGWGIPAVVVSIvltispdnYGIGSYGkfpng 830
Cdd:cd15268    86 CRLVFLLMQYCVAANYYWLLVEGVYLYTLLA--FSVFSEQRIFRlYLSIGWGVPLLFVIP--------WGIVKYL----- 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  831 TPDDFCWI-NSNVVFYITVvgYFCVIFLLNVSMFIVVLVqLCRIKKKKQLGAQRKTSIQDLRSIAGLTF--LLG---ITW 904
Cdd:cd15268   151 YEDEGCWTrNSNMNYWLII--RLPILFAIGVNFLIFIRV-ICIVVSKLKANLMCKTDIKCRLAKSTLTLipLLGtheVIF 227
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569011915  905 GFAFFAWGPVNVTFMYLFA--IFNTLQGFFIFIFYCAAKENV----RKQWRR 950
Cdd:cd15268   228 AFVMDEHARGTLRFVKLFTelSFTSFQGLMVAILYCFVNNEVqmefRKSWER 279
7tmB1_PTHR cd15265
parathyroid hormone receptors, member of the class B family of seven-transmembrane G ...
752-950 6.17e-07

parathyroid hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; The parathyroid hormone (PTH) receptor family has three subtypes: PTH1R, PTH2R and PTH3R. PTH1R is expressed in bone and kidney and is activated by two polypeptide ligands: PTH, an endocrine hormone that regulates calcium homoeostasis and bone maintenance, and PTH-related peptide (PTHrP), a paracrine factor that regulates endochondral bone development. PTH1R couples predominantly to a G(s)-protein that in turn activates adenylate cyclase thereby producing cAMP, but it can also couple to several G protein subtypes, including G(q/11), G(i/o), and G(12/13), resulting in activation of multiple intracellular signaling pathways. PTH2R is potently activated by tuberoinfundibular peptide-39 (TIP-39), but not by PTHrP. PTH also strongly activates human PTH2R, but only weakly activates rat and zebrafish PTH2Rs, suggesting that TIP-39 is a natural ligand for PTH2R. On the other hand, PTH3R binds and responds to both PTH and PTHrP, but not the TIP-39. Moreover, the PTH3R is more closely related to the PTH1R than PTH2R. PTH1R is found in all vertebrate species, whereas PTH2R is found in mammals and fish, but not in chicken or frog. The PTH3R is found in chicken and fish, but it is absent in mammals. The PTH receptors are members of the B1 (or secretin-like) subfamily of class B GPCRs, which include receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), and calcitonin gene-related peptide. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways.


Pssm-ID: 320393 [Multi-domain]  Cd Length: 289  Bit Score: 52.38  E-value: 6.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMY-LALVKVFNTyiRKYILKFCIVGWGIPAVVVSIVLTIspdnygigsygkfpNG 830
Cdd:cd15265    95 CKVAVTLFLYFLATNYYWILVEGLYLHsLIFMAFFSD--KKYLWGFTLIGWGFPAVFVIPWASV--------------RA 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  831 TPDDF-CWINSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLcrIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWG--FA 907
Cdd:cd15265   159 TLADTrCWDLSAGNYKWIYQVPILAAIVVNFILFLNIVRVL--ATKLRETNAGRCDTRQQYRKLAKSTLVLIPLFGvhYI 236
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569011915  908 FFAWGPVNVTF------MYLFAIFNTLQGFFIFIFYC----AAKENVRKQWRR 950
Cdd:cd15265   237 VFMGMPYTEVGllwqirMHYELFFNSFQGFFVAIIYCfcngEVQAEIKKRWER 289
7tmB1_PTH3R cd15983
parathyroid hormone 3 receptor, member of the class B family of seven-transmembrane G ...
753-950 9.71e-07

parathyroid hormone 3 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; The parathyroid hormone 3 receptor (PTH3R), one of the three subtypes of PTH receptor family, is found in chicken and fish, but it is absent in mammals. On the other hand, the PTH1R is found in all vertebrate species, whereas PTH2R is found in mammals and fish, but not in chicken or frog. PTH1R is activated by two polypeptide ligands: PTH, an endocrine hormone that regulates calcium homoeostasis and bone maintenance, and PTH-related peptide (PTHrP), a paracrine factor that regulates endochondral bone development. PTH2R is potently activated by tuberoinfundibular peptide-39 (TIP-39), but not by PTHrP. PTH also strongly activates human PTH2R, but only weakly activates rat and zebrafish PTH2Rs, suggesting that TIP-39 is a natural ligand for PTH2R. Conversely, PTH3R binds and responds to both PTH and PTHrP, but not the TIP-39. The PTH family receptors are members of the B1 (or secretin-like) subfamily of class B GPCRs, which include receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), and calcitonin gene-related peptide. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways.


Pssm-ID: 320649 [Multi-domain]  Cd Length: 285  Bit Score: 51.85  E-value: 9.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  753 IAVAVFLhYFLLVSFTWMGLEAFHMYLALVKVFNTYiRKYILKFCIVGWGIPAVVVSIVLTISPDnygigsygkfpngTP 832
Cdd:cd15983    92 VTVTLFL-YFLATNHYWILVEGLYLHSLIFMAFLSD-KNYLWALTIIGWGLPAVFVSVWASVRVS-------------LA 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  833 DDFCWI----NSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIqdLRSIAGLTFLLGITWgFAF 908
Cdd:cd15983   157 DTQCWDlsagNLKWIYQVPILAAILVNFFLFLNIVRVLASKLWETNTGKLDPRQQYRKL--LKSTLVLMPLFGVHY-VLF 233
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569011915  909 FAWGPVNVTF------MYLFAIFNTLQGFFIFIFYC----AAKENVRKQWRR 950
Cdd:cd15983   234 MAMPYTDVTGllwqiqMHYEMLFNSSQGFFVAFIYCfcngEVQAEIKKAWLR 285
7tmB1_PTH-R_related cd15272
invertebrate parathyroid hormone-related receptors, member of the class B family of ...
760-950 2.33e-06

invertebrate parathyroid hormone-related receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; This group includes parathyroid hormone (PTH)-related receptors found in invertebrates such as mollusks and annelid worms. The PTH family receptors are members of the B1 subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), and calcitonin gene-related peptide. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. The parathyroid hormone type 1 receptor (PTH1R) is found in all vertebrate species and is activated by two polypeptide ligands: parathyroid hormone (PTH), an endocrine hormone that regulates calcium homoeostasis and bone maintenance, and PTH-related peptide (PTHrP), a paracrine factor that regulates endochondral bone development. PTH1R couples predominantly to G(s)- protein that in turn activates adenylyl cyclase thereby producing cAMP, but it can also couple to several G protein subtypes, including G(q/11), G(i/o), and G(12/13), resulting in activation of multiple signaling pathways.


Pssm-ID: 320400 [Multi-domain]  Cd Length: 285  Bit Score: 50.46  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  760 HYFLLVSFTWMGLEAFHMY-LALVKVFNtyIRKYILKFCIVGWG------IPAVVVSIVLTispdnygigsygkfpngtp 832
Cdd:cd15272    98 NYILGANYMWIFVEGLYLHmLIFVAVFS--ENSRVKWYILLGWLspllfvLPWVFVRATLE------------------- 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  833 DDFCW-INSNVVFYITVVGYFCVIFLLNVSMFI-VVLVQLCRIKKkkqlGAQRKTSIQDLRSIAGLTFLLGITWG--FAF 908
Cdd:cd15272   157 DTLCWnTNTNKGYFWIIRGPIVISIAINFLFFInIVRVLFTKLKA----SNTQESRPFRYRKLAKSTLVLIPLFGvhYMV 232
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569011915  909 FAWGPVNVTF-------MYLFAIFNTLQGFFIFIFYC----AAKENVRKQWRR 950
Cdd:cd15272   233 FVVLPDSMSSdeaelvwLYFEMFFNSFQGFIVALLFCflngEVQSEIKKKWQR 285
7tmB1_calcitonin_R cd15274
calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled ...
755-951 5.85e-06

calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; This group includes G protein-coupled receptors for calcitonin (CT) and calcitonin gene-related peptides (CGRPs). Calcitonin, a 32-amino acid peptide hormone, is involved in calcium metabolism in many mammalian species and acts to reduce blood calcium levels and directly inhibits bone resorption by acting on osteoclast. Thus, CT acts as an antagonist to parathyroid hormone and is commonly used in the treatment of bone disorders. The CT receptor is predominantly found in osteoclasts, kidney, and brain, and is primarily coupled to stimulatory G(s) protein, which leads to activation of adenylate cyclase, thereby increasing cAMP production. CGRP, a member of the calcitonin family of peptides, is a potent vasodilator and may contribute to migraine. It is expressed in the peripheral and central nervous system and exists in two forms in humans (alpha-CGRP and beta-CGRP). CGRP meditates its physiological effects through calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1), a single transmembrane domain protein. Thus, the CRLR/RAMP1 complex serves as a functional CGRP receptor. On the other hand, the CRLR/RAMP2 and CRLR/RAMP3 complexes function as adrenomedullin-specific receptors. The CT and CGRP receptors belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide.


Pssm-ID: 341343 [Multi-domain]  Cd Length: 274  Bit Score: 49.39  E-value: 5.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  755 VAVFLHYFLLVS-FTWMGLEAFHMY-LALVKVFNTyiRKYILKFCIVGWGIPAVVVSIvltispdnYGIGSYGKFpngtp 832
Cdd:cd15274    77 ILHFIHQYMMGCnYFWMLCEGIYLHtLIVVAVFAE--KQRLMWYYLLGWGFPLIPTTI--------HAITRAVYY----- 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  833 DDFCWINSNVVFYITVVGYFCVIFLLNVsMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITwgFAFFAWG 912
Cdd:cd15274   142 NDNCWLSSETHLLYIIHGPIMAALVVNF-FFLLNIVRVLVTKLRETHEAESHMYLKAVKATLILVPLLGIQ--FVLFPWR 218
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 569011915  913 PVNV----TFMYLFAIFNTLQGFFIFIFYCAAKENV----RKQWRRY 951
Cdd:cd15274   219 PSGKilgkIYDYVMHSLIHFQGFFVATIFCFCNGEVqatlKRQWNQY 265
7tmB1_secretin cd15275
secretin receptor, member of the class B family of seven-transmembrane G protein-coupled ...
692-950 5.93e-06

secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Secretin receptor is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include vasoactive intestinal peptide (VIP), growth-hormone-releasing hormone (GHRH), and pituitary adenylate cyclase activating polypeptide (PACAP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors, and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. Secretin, a polypeptide secreted by entero-endocrine S cells in the small intestine, is involved in maintaining body fluid balance. This polypeptide regulates the secretion of bile and bicarbonate into the duodenum from the pancreatic and biliary ducts, as well as regulates the duodenal pH by the control of gastric acid secretion. Studies with secretin receptor-null mice indicate that secretin plays a role in regulating renal water reabsorption. Secretin mediates its biological actions by elevating intracellular cAMP via G protein-coupled secretin receptor, which is expressed in the brain, pancreas, stomach, kidney, and liver.


Pssm-ID: 320403 [Multi-domain]  Cd Length: 271  Bit Score: 49.35  E-value: 5.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  692 IGCGLSSIFLSVTLVTYIAFEKIR--RDY------PSKILIQLCAALLLLNLIFLLDSWIALYNTRGfCIAVAVFLHYFL 763
Cdd:cd15275    10 VGYSVSLVSLAIALAILCSFRRLHctRNYihmqlfLSFILRAISIFIKDAVLFSSEDDNHCDIYTVG-CKVAMVFSNYCI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  764 LVSFTWMGLEAFHMYLALVKVFNTyIRKYILKFCIVGWGIPAVVVSivltispdNYGIGSYgkfpnGTPDDFCW-INSNV 842
Cdd:cd15275    89 MANYSWLLVEGLYLHSLLSISFFS-ERKHLWWYIALGWGSPLIFII--------SWAIARY-----LHENEGCWdTRRNA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  843 VFYITVVGYFCVIFLLNVSMFIVVLVQLcrIKKKKQLGAQRKTSIQdLRSIAGLTFLLGITWG-----FAFFAWGPVNVT 917
Cdd:cd15275   155 WIWWIIRGPVILSIFVNFILFLNILRIL--MRKLRAPDMRGNEFSQ-YKRLAKSTLLLIPLFGlhyilFAFFPEDVSSGT 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 569011915  918 F-MYLFA--IFNTLQGFFIFIFYC----AAKENVRKQWRR 950
Cdd:cd15275   232 MeIWLFFelALGSFQGFVVAVLYCflngEVQLEIQRKWRR 271
7tmB2_GPR125 cd15999
G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G ...
752-953 9.22e-06

G protein-coupled receptor 125, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR125 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, which also includes orphan receptors GPR123 and GPR124. GPR125 directly interacts with dishevelled (Dvl) via its intracellular C-terminus, and together, GPR125 and Dvl recruit a subset of planar cell polarity (PCP) components into membrane subdomains, a prerequisite for activation of Wnt/PCP signaling. Thus, GPR125 influences the noncanonical WNT/PCP pathway, which does not involve beta-catenin, through interacting with and modulating the distribution of Dvl. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320665  Cd Length: 312  Bit Score: 49.09  E-value: 9.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIR--------KYILKFCIVGWGIPAVVVSIVLTISpdnygIGS 823
Cdd:cd15999    70 CQAVGIILHYSTLATVLWVGVTARNIYKQVTRKAKRCQDpdepppppRPMLRFYLIGGGIPIIVCGITAAAN-----IKN 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  824 YGKFPNGTpddFCWIN---SNVVFYitvvGYFCVIFLLNVSMFIVVLVQLCRIKKKK-------------------QLGA 881
Cdd:cd15999   145 YGSRPNAP---YCWMAwepSLGAFY----GPAGFIIFVNCMYFLSIFIQLKRHPERKyelkepteeqqrlaasehgELNH 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  882 QRKTSIQDLRSI------------------AGLT-FLLGITWGFAFFA---WGPVNVTFMYLFAIFNTLQGFFIFIFYCA 939
Cdd:cd15999   218 QDSGSSSASCSLvstsalenehsfqaqllgASLAlFLYVALWIFGALAvslYYPMDLVFSCLFGATCLSLGAFLVVHHCV 297
                         250
                  ....*....|....
gi 569011915  940 AKENVRKQWRRYLC 953
Cdd:cd15999   298 NREDVRRAWIATCC 311
7tmB1_GlucagonR-like cd15929
glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G ...
752-952 2.05e-05

glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors; This group represents the glucagon receptor family of G protein-coupled receptors, which includes glucagon receptor (GCGR), glucagon-like peptide-1 receptor (GLP1R), GLP2R, and closely related receptors. These receptors are activated by the members of the glucagon (GCG) peptide family including GCG, glucagon-like peptide 1 (GLP1), and GLP2, which are derived from the large proglucagon precursor. GCGR regulates blood glucose levels by control of hepatic glycogenolysis and gluconeogenesis and by regulation of insulin secretion from the pancreatic beta-cells. Activation of GLP1R stimulates glucose-dependent insulin secretion from pancreatic beta cells, whereas activation of GLP2R stimulates intestinal epithelial proliferation and increases villus height in the small intestine. Receptors in this group belong to the B1 (or secretin-like) subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on their cellular location, GCGR and GLP receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 341353 [Multi-domain]  Cd Length: 279  Bit Score: 47.43  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALvkVFNTYIRKYILK-FCIVGWGIPavvvsiVLTISPdnYGIGSYGKfpng 830
Cdd:cd15929    86 CRVAQVLMQYCVAANYYWLLVEGLYLHTLL--VLAVFSERSIFRlYLLLGWGAP------VLFVVP--WGIVKYLY---- 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  831 tPDDFCW-INSNVVFYITVVGYFCVIFLLNVSMFIVVLvQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWG-FAF 908
Cdd:cd15929   152 -ENTGCWtRNDNMAYWWIIRLPILLAILINFFIFVRIL-KILVSKLRANQMCKTDYKFRLAKSTLTLIPLLGVHEVvFAF 229
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 569011915  909 F----AWGpvNVTFMYLFA--IFNTLQGFFIFIFYCAAKENVRKQWRRYL 952
Cdd:cd15929   230 VtdeqARG--TLRFIKLFFelFLSSFQGLLVAVLYCFANKEVQSELRKKW 277
7tmB1_GlucagonR-like_1 cd15985
uncharacterized group of glucagon receptor-like proteins, member of the class B family of ...
752-949 2.56e-05

uncharacterized group of glucagon receptor-like proteins, member of the class B family of seven-transmembrane G protein-coupled receptors; This group consists of uncharacterized proteins with similarity to members of the glucagon receptor family of G protein-coupled receptors, which include glucagon receptor (GCGR), and glucagon-like peptide-1 receptor (GLP1R), and GLP2R. The glucagon receptors are activated by the members of the glucagon (GCG) peptide family including GCG, glucagon-like peptide 1 (GLP1), and GLP2, which are derived from the large proglucagon precursor. GCGR regulates blood glucose levels by control of hepatic glycogenolysis and gluconeogenesis and by regulation of insulin secretion from the pancreatic beta-cells. Activation of GLP1R stimulates glucose-dependent insulin secretion from pancreatic beta cells, whereas activation of GLP2R stimulates intestinal epithelial proliferation and increases villus height in the small intestine. Receptors in this group belong to the B1 (or secretin-like) subfamily of class B GPCRs, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. However, depending on their cellular location, GCGR and GLP receptors can activate multiple G proteins, which can in turn stimulate different second messenger pathways.


Pssm-ID: 320651 [Multi-domain]  Cd Length: 280  Bit Score: 47.23  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIvGWGIPAVVVSIVLTISpdnygigsYGKfpngt 831
Cdd:cd15985    87 CRMAQVVMQYCILANHYWFFVEAVYLYKLLIGAVFSEKNYYLLYLYL-GWGTPVLFVVPWMLAK--------YLK----- 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  832 PDDFCW-INSNVVFYITVVGYFCVIFLLNVSMFIVVL-VQLCRIKKKKQLGAQRKTSIQdlRSIAGLTFLLGITWGFAFF 909
Cdd:cd15985   153 ENKECWaLNENMAYWWIIRIPILLASLINLLIFMRILkVILSKLRANQKGYADYKLRLA--KATLTLIPLFGIHEVVFIF 230
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 569011915  910 AWGPVNVTFMYLFAIF-----NTLQGFFIFIFYCAAKENVR----KQWR 949
Cdd:cd15985   231 ATDEQTTGILRYIKVFftlflNSFQGFLVAVLYCFANKEVKsellKKWR 279
PHA03247 PHA03247
large tegument protein UL36; Provisional
301-441 3.30e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  301 PHGPPLSSSSKPVVPQATIishvasdfSLAEPLDhALMTPSTPSLTQEsnlPSPQPTIPLASSPATDLPVQSvvvssLPQ 380
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTE--------SFALPPD-QPERPPQPQAPPP---PQPQPQPPPPPQPQPPPPPPP-----RPQ 2940
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011915  381 TDLSHTLSPVQSSIPSPTTPAP----------SVPTELVTISTPPGET-VVNTSTVSDLEA-QVSQMEKALSL 441
Cdd:PHA03247 2941 PPLAPTTDPAGAGEPSGAVPQPwlgalvpgrvAVPRFRVPQPAPSREApASSTPPLTGHSLsRVSSWASSLAL 3013
7tmB1_GHRHR cd15270
growth-hormone-releasing hormone receptor, member of the class B family of seven-transmembrane ...
752-950 6.39e-05

growth-hormone-releasing hormone receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Growth hormone-releasing hormone receptor (GHRHR) is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, pituitary adenylate cyclase activating polypeptide (PACAP), and vasoactive intestinal peptide. These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. GHRHR is a specific receptor for the growth hormone-releasing hormone (GHRH) that controls the synthesis and release of growth hormone (GH) from the anterior pituitary somatotrophs. Mutations in the gene encoding GHRHR have been connected to isolated growth hormone deficiency (IGHD), a short-stature condition caused by deficient production of GH or lack of GH action. GHRH is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level. GHRHR is found in mammals as well as zebrafish and chicken, whereas the GHRHR type 2, an ortholog of the GHRHR, has only been identified in ray-finned fish, chicken and Xenopus. Xenopus laevis GHRHR2 has been shown to interact with both endogenous GHRH and PACAP-related peptide (PRP).


Pssm-ID: 320398 [Multi-domain]  Cd Length: 268  Bit Score: 45.94  E-value: 6.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFnTYIRKYILKFCIVGWGIPavVVSIVLTISPDNYgigsygkfpngT 831
Cdd:cd15270    77 CKVSVVFCHYCVMTNFFWLLVEAVYLNCLLASSF-PRGKRYFWWLVLLGWGLP--TLCTGTWILCKLY-----------F 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  832 PDDFCW-INSNVVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDL-RSIAGLTFLLGITWGFAFF 909
Cdd:cd15270   143 EDTECWdINNDSPYWWIIKGPIVISVGVNFLLFLNIIRILLKKLDPRQINFNNSAQYRRLsKSTLLLIPLFGTHYIIFNF 222
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 569011915  910 AWGPVNVTF-MYLFAIFNTLQGFFIFIFYCAAKENVRKQWRR 950
Cdd:cd15270   223 LPDYAGLGIrLYLELCLGSFQGFIVAVLYCFLNQEVQTEISR 264
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
351-542 6.50e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 46.88  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  351 LPSPQPTIPLASSPATDLPVQSVV----VSSLPQTDLSHTLSPVQSSIP-SPTTPAPSVPTELVTISTPPgETVVNTSTV 425
Cdd:PRK14948  360 LPSAFISEIANASAPANPTPAPNPspppAPIQPSAPKTKQAATTPSPPPaKASPPIPVPAEPTEPSPTPP-ANAANAPPS 438
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  426 SDLEAQVSQMekalsLGSLEPNLAGEMVNRVSKL--LHSPPALLApLAQRLLKVV--------DAI------GLQLNFSS 489
Cdd:PRK14948  439 LNLEELWQQI-----LAKLELPSTRMLLSQQAELvsLDSNRAVIA-VSPNWLGMVqsrkplleQAFakvlgrSIKLNLES 512
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569011915  490 TTISLTSPSLALAVIRVNASNFNTTTFAAQDPTNLQVSLETPPPENSIGAITL 542
Cdd:PRK14948  513 QSGSASNTAKTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSN 565
PHA03369 PHA03369
capsid maturational protease; Provisional
309-619 1.85e-04

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 45.38  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  309 SSKPVVPQATIISHVASDFSLAEPldhalMTPSTPSLTQESNLPSPQPTIPLASSPATDLPVQSVVVSSLPQTDLSHTLS 388
Cdd:PHA03369  349 KTASLTAPSRVLAAAAKVAVIAAP-----QTHTGPADRQRPQRPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQS 423
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  389 PVQSSIPSPTTPAPSVPTELVTISTPPGETVVNTstvsdLEAQVSQMEKALSLGSLEPNLAgEMVNRVSKLLHSPPALLA 468
Cdd:PHA03369  424 PGTSYGPEPVGPVPPQPTNPYVMPISMANMVYPG-----HPQEHGHERKRKRGGELKEELI-ETLKLVKKLKEEQESLAK 497
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  469 PLAQRLLKvvdaiGLQLNFSSTTISLTSPSLALAVIRVNASnfntttfAAQDPTNLQvsleTPPPEnsigaitlpsslmn 548
Cdd:PHA03369  498 ELEATAHK-----SEIKKIAESEFKNAGAKTAAANIEPNCS-------ADAAAPATK----RARPE-------------- 547
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011915  549 nlPANDVELASRI--QFNFFETPALFQDPSLENLTLISYVISSSVTNMT--IKNLTRNVTValkhiNPSPDDLTV 619
Cdd:PHA03369  548 --TKTELEAVVRFpyQIRNMESPAFVHSFTSTTLAAAAGQGSDTAEALAgaIETLLTQASA-----QPAGLSLPA 615
7tmB1_VIP-R2 cd15986
vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of ...
752-810 1.06e-03

vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors; Vasoactive intestinal peptide (VIP) receptor 2 is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, growth-hormone-releasing hormone (GHRH), and pituitary adenylate cyclase activating polypeptide (PACAP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. VIP and PACAP exert their effects through three G protein-coupled receptors, PACAP-R1, VIP-R1 (vasoactive intestinal receptor type 1, also known as VPAC1) and VIP-R2 (or VPAC2). PACAP-R1 binds only PACAP with high affinity, whereas VIP-R1 and -R2 specifically bind and respond to both VIP and PACAP. VIP and PACAP and their receptors are widely expressed in the brain and periphery. They are upregulated in neurons and immune cells in responses to CNS injury and/or inflammation and exert potent anti-inflammatory effects, as well as play important roles in the control of circadian rhythms and stress responses, among many others. VIP-R1 is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level. However, depending on its cellular location, VIP-R1 is also capable of coupling to additional G proteins such as G(q) protein, thus leading to the activation of phospholipase C and intracellular calcium influx.


Pssm-ID: 320652 [Multi-domain]  Cd Length: 269  Bit Score: 42.10  E-value: 1.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTyiRKYILKFCIVGWGIPAVVVSI 810
Cdd:cd15986    79 CKVSLVILQYCIMANFYWLLVEGLYLHTLLVVIFSE--NRHFIVYLLIGWGIPTVFIIA 135
7tmF_Frizzled_SMO cd13951
class F frizzled/smoothened family, member of the 7-transmembrane G protein-coupled receptor ...
752-927 3.03e-03

class F frizzled/smoothened family, member of the 7-transmembrane G protein-coupled receptor superfamily; The class F G protein-coupled receptors includes the frizzled (FZD) family of seven-transmembrane proteins consisting of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. Also included in the class F family is the closely related smoothened (SMO), which is a transmembrane G protein-coupled receptor that acts as the transducer of the hedgehog (HH) signaling pathway. SMO is activated by the hedgehog (HH) family of proteins acting on the 12-transmembrane domain receptor patched (PTCH), which constitutively inhibits SMO. Thus, in the absence of HH proteins, PTCH inhibits SMO signaling. On the other hand, binding of HH to the PTCH receptor activates its internalization and degradation, thereby releasing the PTCH inhibition of SMO. This allows SMO to trigger intracellular signaling and the subsequent activation of the Gli family of zinc finger transcriptional factors and induction of HH target gene expression (PTCH, Gli1, cyclin, Bcl-2, etc). The WNT and HH signaling pathways play critical roles in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.


Pssm-ID: 320089  Cd Length: 314  Bit Score: 41.15  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  752 CIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNT-YIRKYILKFCIVGWGIPAVVVSIVLT---ISPDNY-GIgsygk 826
Cdd:cd13951    94 CAIVFLLTYYFGMAASIWWVILTLTWFLSAGLKWSSeAIEKKSSYFHLVAWGLPAVLTIAVLVlrkVDGDELtGI----- 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  827 fpngtpddfCWI-NSNVVFYITVVGYFCVIFLLNVSMFIVV-LVQLCRIKKKKQlGAQRKTSIQDLRSIagltfLLGItw 904
Cdd:cd13951   169 ---------CFVgNQNLDALRGFVLAPLFLYLILGTVFLLCgFLSLFRIRSILS-NDGKKTDKLEKLML-----RIGI-- 231
                         170       180
                  ....*....|....*....|....
gi 569011915  905 gFAFFAWGPVNVTF-MYLFAIFNT 927
Cdd:cd13951   232 -FAVLYTLPALIVIaCYFYEYANR 254
KLF8_12_N cd21093
N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins; Kruppel-like ...
324-402 4.62e-03

N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins; Kruppel-like transcription factors (also known as Krueppel-like transcription factors, KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. This model represents the related N-terminal activation/repression domains of KLF8 and KLF12.


Pssm-ID: 410606 [Multi-domain]  Cd Length: 172  Bit Score: 39.37  E-value: 4.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011915  324 ASDFSL--AEPLDHALMTPSTPSLTQESNLPSPQPTIPLASSPAtdlPVQSVVVSSLpqtdlshTLSPVQSSIPSPTTPA 401
Cdd:cd21093    29 SSDHSQpqTEPVDLSINKARTSPTAVSSSPVSMSSSISSSSSSS---PRPASSPTVI-------TSVSSASAIPTVLSPG 98

                  .
gi 569011915  402 P 402
Cdd:cd21093    99 S 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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