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Conserved domains on  [gi|568909529|ref|XP_006529872|]
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integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X3 [Mus musculus]

Protein Classification

PP2C family serine/threonine-protein phosphatase( domain architecture ID 10065450)

PP2C family protein-serine/threonine phosphatase catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues of specific protein substrates

CATH:  3.60.40.10
EC:  3.1.3.16
Gene Ontology:  GO:0004722|GO:0006470|GO:0046872
PubMed:  9192069|8819174
SCOP:  3000909

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
100-382 1.80e-91

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


:

Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 275.36  E-value: 1.80e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 100 KGYVAERKGEREEMQDAHVILNDITQEcnppsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDIISvEKTV 179
Cdd:cd00143    2 SAGVSDKGGDRKTNEDAVVIKPNLNNE---------DGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLS-EEDI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 180 KRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEE 259
Cdd:cd00143   72 EEALRKAFLRADEEILEEAQDEPDDARSGTTAVVALIRGNKLYVANVGDSRAVLCR------NGEAVQLTKDHKPVNEEE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 260 RMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 339
Cdd:cd00143  146 RERIEKAGGRVSNGRVPGVLAVTRALGDFDLK-PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSELAK 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568909529 340 DKIQtregkpavdaryeAACNRLANKAVQRGSADNVTVMVVRI 382
Cdd:cd00143  225 EDLQ-------------EAAQELVDLALRRGSHDNITVVVVRL 254
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
100-382 1.80e-91

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 275.36  E-value: 1.80e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 100 KGYVAERKGEREEMQDAHVILNDITQEcnppsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDIISvEKTV 179
Cdd:cd00143    2 SAGVSDKGGDRKTNEDAVVIKPNLNNE---------DGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLS-EEDI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 180 KRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEE 259
Cdd:cd00143   72 EEALRKAFLRADEEILEEAQDEPDDARSGTTAVVALIRGNKLYVANVGDSRAVLCR------NGEAVQLTKDHKPVNEEE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 260 RMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 339
Cdd:cd00143  146 RERIEKAGGRVSNGRVPGVLAVTRALGDFDLK-PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSELAK 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568909529 340 DKIQtregkpavdaryeAACNRLANKAVQRGSADNVTVMVVRI 382
Cdd:cd00143  225 EDLQ-------------EAAQELVDLALRRGSHDNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
89-380 1.26e-83

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 254.99  E-value: 1.26e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529    89 VCKASSVIFGLkgyvAERKGEREEMQDAHVILNDitqecnppssLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFP 168
Cdd:smart00332   3 SGKNLGLRYGL----SSMQGVRKPMEDAHVITPD----------LSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELI 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529   169 KGDiiSVEKTVKRCLLDTFKHTDEEFLkqassQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEesqkhaALSL 248
Cdd:smart00332  69 KEK--DELEDVEEALRKAFLSTDEEIL-----EELEALSGSTAVVALISGNKLYVANVGDSRAVLCRNGK------AVQL 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529   249 SKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEE 328
Cdd:smart00332 136 TEDHKPSNEDERARIEAAGGFVINGRVNGVLALSRAIGDFFLK-PYVSAEPDVTVVELTEKDDFLILASDGLWDVLSNQE 214
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568909529   329 AVNFILSCLEDDkiqtregkpavdarYEAACNRLANKAVQRGSADNVTVMVV 380
Cdd:smart00332 215 VVDIVRKHLSKD--------------PKEAAKRLIDLALARGSKDNITVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
105-375 1.08e-65

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 209.11  E-value: 1.08e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529  105 ERKGEREEMQDAHVILNDitQECNPPSSlitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRK--FPKGDiisvekTVKRC 182
Cdd:pfam00481   7 RMQGWRKSMEDAHIDLPN--LNSSSGKD---SWSFFAVFDGHGGSEAAKYCGKHLHTILALRrsFLEGE------KLEDA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529  183 LLDTF-KHTDEEFlkqASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesQKHAALSLSKEHNPTQYEERM 261
Cdd:pfam00481  76 LRKSFlEDTDEVL---RSAEKEDLDSGCTAVVALISGNKLYVANVGDSRAVLCR-----NGNAIKRLTKDHKPSDEDERR 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529  262 RIQKAGGNV-RDGRVLGVLEVSRSIGDGQYKR--CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLE 338
Cdd:pfam00481 148 RIRAAGGFVsRNGRVNGVLAVSRAFGDFELKPgeQAVSAEPDITSHTITEDDEFLILACDGLWDVLSDQEVVDLVRSELS 227
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 568909529  339 DDKIQTRegkpavdaryeaACNRLANKAVQRGSADNV 375
Cdd:pfam00481 228 DGGSPME------------AAEELRDEAIAYGSEDNI 252
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
108-382 5.53e-42

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 151.08  E-value: 5.53e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 108 GEREEMQDAHVILnditqecnppssLITRVSYFAVFDGHGGIRASKFAAQNLHQnLIRKFPKgdiisvektvkrclldtf 187
Cdd:PTZ00224  31 GYRESMEDAHLLY------------LTDDWGFFGVFDGHVNDECSQYLARAWPQ-ALEKEPE------------------ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 188 KHTDEEFLKQASSQKPAWKD-----GSTAT-CVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEERM 261
Cdd:PTZ00224  80 PMTDERMEELCLEIDEEWMDsgregGSTGTfCVIMKDVHLQVGNVGDSRVLVCR------DGKLVFATEDHKPNNPGERQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 262 RIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDrFILLACDGLFK-VFTPEEAVNF 332
Cdd:PTZ00224 154 RIEACGGRVVSNRVDGDLAVSRAFGDRSFKVKGtgdyleqkVIAVPDVTHLTCQSND-FIILACDGVFEgNFSNEEVVAF 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568909529 333 ILSCLEDdkiqtregkpaVDARYEAACnRLANKAVQRGSADNVTVMVVRI 382
Cdd:PTZ00224 233 VKEQLET-----------CDDLAVVAG-RVCDEAIRRGSKDNISCLIVQL 270
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
110-383 8.43e-23

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 96.05  E-value: 8.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 110 REEMQDAHVILNDitqecnPPSSLitrvsyFAVFDGHGGIR----ASKFAAQNLHQNLIRKFPKGdiisvEKTVKRCLLD 185
Cdd:COG0631   13 RENNEDAFLVALD------PGGGL------FVVADGMGGHAagevASRLAVETLAELFQEALAPD-----PEDLEEALRE 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 186 TFKHTDEEfLKQASSQKPAWKD-GSTATCVLAVDNILYIANLGDSRAILCRYNEESQkhaalsLSKEHNPTQYEERM-RI 263
Cdd:COG0631   76 AIRAANRA-ILELAQEDPELAGmGTTLVAALIAGGRLYIAHVGDSRAYLLRDGELEQ------LTRDHSLVQELVDAgRI 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 264 QKAGGNVRDGRvlGVLevSRSIGDGQykrcgvTSVPDIRRCQLTPNDRFiLLACDGLFKVFTPEEavnfILSCLeddkiq 343
Cdd:COG0631  149 TPEEARTHPQR--NVL--TRALGTDD------DVEPDISPLELEPGDRL-LLCSDGLTDMVSDEE----IAEIL------ 207
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568909529 344 tREGKPAvdaryEAACNRLANKAVQRGSADNVTVMVVRIG 383
Cdd:COG0631  208 -ASAGDP-----QEAAEALIELALEAGGPDNITVVLVRVE 241
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
100-382 1.80e-91

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 275.36  E-value: 1.80e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 100 KGYVAERKGEREEMQDAHVILNDITQEcnppsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDIISvEKTV 179
Cdd:cd00143    2 SAGVSDKGGDRKTNEDAVVIKPNLNNE---------DGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLS-EEDI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 180 KRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEE 259
Cdd:cd00143   72 EEALRKAFLRADEEILEEAQDEPDDARSGTTAVVALIRGNKLYVANVGDSRAVLCR------NGEAVQLTKDHKPVNEEE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 260 RMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 339
Cdd:cd00143  146 RERIEKAGGRVSNGRVPGVLAVTRALGDFDLK-PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSELAK 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568909529 340 DKIQtregkpavdaryeAACNRLANKAVQRGSADNVTVMVVRI 382
Cdd:cd00143  225 EDLQ-------------EAAQELVDLALRRGSHDNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
89-380 1.26e-83

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 254.99  E-value: 1.26e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529    89 VCKASSVIFGLkgyvAERKGEREEMQDAHVILNDitqecnppssLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFP 168
Cdd:smart00332   3 SGKNLGLRYGL----SSMQGVRKPMEDAHVITPD----------LSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELI 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529   169 KGDiiSVEKTVKRCLLDTFKHTDEEFLkqassQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEesqkhaALSL 248
Cdd:smart00332  69 KEK--DELEDVEEALRKAFLSTDEEIL-----EELEALSGSTAVVALISGNKLYVANVGDSRAVLCRNGK------AVQL 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529   249 SKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEE 328
Cdd:smart00332 136 TEDHKPSNEDERARIEAAGGFVINGRVNGVLALSRAIGDFFLK-PYVSAEPDVTVVELTEKDDFLILASDGLWDVLSNQE 214
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568909529   329 AVNFILSCLEDDkiqtregkpavdarYEAACNRLANKAVQRGSADNVTVMVV 380
Cdd:smart00332 215 VVDIVRKHLSKD--------------PKEAAKRLIDLALARGSKDNITVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
105-375 1.08e-65

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 209.11  E-value: 1.08e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529  105 ERKGEREEMQDAHVILNDitQECNPPSSlitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRK--FPKGDiisvekTVKRC 182
Cdd:pfam00481   7 RMQGWRKSMEDAHIDLPN--LNSSSGKD---SWSFFAVFDGHGGSEAAKYCGKHLHTILALRrsFLEGE------KLEDA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529  183 LLDTF-KHTDEEFlkqASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesQKHAALSLSKEHNPTQYEERM 261
Cdd:pfam00481  76 LRKSFlEDTDEVL---RSAEKEDLDSGCTAVVALISGNKLYVANVGDSRAVLCR-----NGNAIKRLTKDHKPSDEDERR 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529  262 RIQKAGGNV-RDGRVLGVLEVSRSIGDGQYKR--CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLE 338
Cdd:pfam00481 148 RIRAAGGFVsRNGRVNGVLAVSRAFGDFELKPgeQAVSAEPDITSHTITEDDEFLILACDGLWDVLSDQEVVDLVRSELS 227
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 568909529  339 DDKIQTRegkpavdaryeaACNRLANKAVQRGSADNV 375
Cdd:pfam00481 228 DGGSPME------------AAEELRDEAIAYGSEDNI 252
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
108-382 5.53e-42

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 151.08  E-value: 5.53e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 108 GEREEMQDAHVILnditqecnppssLITRVSYFAVFDGHGGIRASKFAAQNLHQnLIRKFPKgdiisvektvkrclldtf 187
Cdd:PTZ00224  31 GYRESMEDAHLLY------------LTDDWGFFGVFDGHVNDECSQYLARAWPQ-ALEKEPE------------------ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 188 KHTDEEFLKQASSQKPAWKD-----GSTAT-CVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEERM 261
Cdd:PTZ00224  80 PMTDERMEELCLEIDEEWMDsgregGSTGTfCVIMKDVHLQVGNVGDSRVLVCR------DGKLVFATEDHKPNNPGERQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 262 RIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDrFILLACDGLFK-VFTPEEAVNF 332
Cdd:PTZ00224 154 RIEACGGRVVSNRVDGDLAVSRAFGDRSFKVKGtgdyleqkVIAVPDVTHLTCQSND-FIILACDGVFEgNFSNEEVVAF 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568909529 333 ILSCLEDdkiqtregkpaVDARYEAACnRLANKAVQRGSADNVTVMVVRI 382
Cdd:PTZ00224 233 VKEQLET-----------CDDLAVVAG-RVCDEAIRRGSKDNISCLIVQL 270
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
108-380 1.43e-39

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 144.29  E-value: 1.43e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 108 GEREEMQDAHVILNDITQECNPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLI--RKFPKgdiisvekTVKRCLLD 185
Cdd:PLN03145  74 GSRSSMEDVYICVDNFMSDFGLKNSEDGPSAFYGVFDGHGGKHAADFACYHLPRFIVedEDFPR--------EIEKVVSS 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 186 TFKHTDEEFLKqASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEERMRIQK 265
Cdd:PLN03145 146 AFLQTDTAFAE-ACSLDASLASGTTALAALVVGRSLVVANAGDCRAVLCR------RGKAIEMSRDHKPMCSKERKRIEA 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 266 AGGNVRDGRVLGVLEVSRSIGDGQY-----KRCGVTSV-PDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 339
Cdd:PLN03145 219 SGGYVYDGYLNGQLNVARALGDWHMegmkgSDGGPLSAePELMTTQLTEEDEFLIIGCDGIWDVFRSQNAVDFARRRLQE 298
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568909529 340 dkiqtrEGKPAvdaryeAACNRLANKAVQRGSADNVTVMVV 380
Cdd:PLN03145 299 ------HNDPV------MCSKELVDEALKRKSGDNLAVVVV 327
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
110-383 8.43e-23

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 96.05  E-value: 8.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 110 REEMQDAHVILNDitqecnPPSSLitrvsyFAVFDGHGGIR----ASKFAAQNLHQNLIRKFPKGdiisvEKTVKRCLLD 185
Cdd:COG0631   13 RENNEDAFLVALD------PGGGL------FVVADGMGGHAagevASRLAVETLAELFQEALAPD-----PEDLEEALRE 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 186 TFKHTDEEfLKQASSQKPAWKD-GSTATCVLAVDNILYIANLGDSRAILCRYNEESQkhaalsLSKEHNPTQYEERM-RI 263
Cdd:COG0631   76 AIRAANRA-ILELAQEDPELAGmGTTLVAALIAGGRLYIAHVGDSRAYLLRDGELEQ------LTRDHSLVQELVDAgRI 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909529 264 QKAGGNVRDGRvlGVLevSRSIGDGQykrcgvTSVPDIRRCQLTPNDRFiLLACDGLFKVFTPEEavnfILSCLeddkiq 343
Cdd:COG0631  149 TPEEARTHPQR--NVL--TRALGTDD------DVEPDISPLELEPGDRL-LLCSDGLTDMVSDEE----IAEIL------ 207
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568909529 344 tREGKPAvdaryEAACNRLANKAVQRGSADNVTVMVVRIG 383
Cdd:COG0631  208 -ASAGDP-----QEAAEALIELALEAGGPDNITVVLVRVE 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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