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Conserved domains on  [gi|568956406|ref|XP_006530869|]
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solute carrier family 35 member F3 isoform X2 [Mus musculus]

Protein Classification

solute carrier family 35 protein( domain architecture ID 710040)

solute carrier family 35 protein is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others; belongs to the DMT (drug/metabolite transporter) superfamily

Gene Ontology:  GO:0022857|GO:0055085
PubMed:  28350329|11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhaT super family cl34009
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 70-166 7.37e-08

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


The actual alignment was detected with superfamily member COG0697:

Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 52.92  E-value: 7.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956406  70 TLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHSV-IGIALVVG 148
Cdd:COG0697   77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSlLGDLLALL 156

                         90
                 ....*....|....*...
gi 568956406 149 SASMSALYKVLFKLLLGS 166
Cdd:COG0697  157 AALSWALYTVLTRRLSRR 174
 
Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 70-166 7.37e-08

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 52.92  E-value: 7.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956406  70 TLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHSV-IGIALVVG 148
Cdd:COG0697   77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSlLGDLLALL 156

                         90
                 ....*....|....*...
gi 568956406 149 SASMSALYKVLFKLLLGS 166
Cdd:COG0697  157 AALSWALYTVLTRRLSRR 174
SLC35F pfam06027
Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.
 73-182 2.32e-05

Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.


Pssm-ID: 283644 [Multi-domain]  Cd Length: 299  Bit Score: 45.52  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956406   73 NYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYAD---GFHSHS----VIGIAL 145
Cdd:pfam06027  87 NYLVVKAYQYTTMTSVQLLDCWAIPVVLVLSWFFLKTRYRLMHIIGVVVCILGVVMMVGSDvlaGRRAYSgsnpLKGDFL 166

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568956406  146 VVGSASMSALYKVLFKLLLGSAKFGEAALFLSILGVF 182
Cdd:pfam06027 167 VLAGATLYAVSNVTEEYIVKKLSRVEFLGMLGLFGAI 203
 
Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 70-166 7.37e-08

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 52.92  E-value: 7.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956406  70 TLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHSV-IGIALVVG 148
Cdd:COG0697   77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSlLGDLLALL 156

                         90
                 ....*....|....*...
gi 568956406 149 SASMSALYKVLFKLLLGS 166
Cdd:COG0697  157 AALSWALYTVLTRRLSRR 174
SLC35F pfam06027
Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.
 73-182 2.32e-05

Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.


Pssm-ID: 283644 [Multi-domain]  Cd Length: 299  Bit Score: 45.52  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956406   73 NYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYAD---GFHSHS----VIGIAL 145
Cdd:pfam06027  87 NYLVVKAYQYTTMTSVQLLDCWAIPVVLVLSWFFLKTRYRLMHIIGVVVCILGVVMMVGSDvlaGRRAYSgsnpLKGDFL 166

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568956406  146 VVGSASMSALYKVLFKLLLGSAKFGEAALFLSILGVF 182
Cdd:pfam06027 167 VLAGATLYAVSNVTEEYIVKKLSRVEFLGMLGLFGAI 203
RhtA COG5006
Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];
62-159 6.46e-04

Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];


Pssm-ID: 444030 [Multi-domain]  Cd Length: 290  Bit Score: 40.96  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956406  62 AAPFGVLWTLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDrfmgvrIVAAILAIAGIVMMTYA-DGFHSHSV 140
Cdd:COG5006   71 LLLYGVALAGMNLLFYLAIARIPLGIAVALEFLGPLAVALLGSRRRRD------LLWVALALAGVVLLLPVgLSGGSLDP 144

                         90
                 ....*....|....*....
gi 568956406 141 IGIALVVGSASMSALYKVL 159
Cdd:COG5006  145 VGVLFALGAAACWALYILL 163
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 70-131 4.62e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 36.79  E-value: 4.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568956406   70 TLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTY 131
Cdd:pfam00892  75 FLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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