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Conserved domains on  [gi|568976585|ref|XP_006534647|]
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small G protein signaling modulator 2 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RUN super family cl45896
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 18-152 2.16e-86

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


The actual alignment was detected with superfamily member cd17704:

Pssm-ID: 459241  Cd Length: 180  Bit Score: 274.12  E-value: 2.16e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAEDICHKVQELQQQAE 97
Cdd:cd17704    1 KEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568976585  98 GRKPSGGSQEALRKQGSTGGKAPALSPQALKHIWVRTALMEKVLDRVVQYLAENC 152
Cdd:cd17704   81 GRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQYIVDNC 135
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 163-311 1.45e-77

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


:

Pssm-ID: 275431  Cd Length: 176  Bit Score: 250.33  E-value: 1.45e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585 163 PQKTGLPPAPV---STWSLCTRTQEHACSMART----TCWCSRVYWDYALVVPFSQIVCIHCHQQ-KSGGTLVLVSQDGI 234
Cdd:cd15784   20 PIKGYLSLHQTgrgNLTLKWTPNQLMNGSSQASsaksNSLDSSVYWDYALSVNLDDIVYIHCHQQdDSGGTVVLVGQDGV 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568976585 235 QRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSIDVEELGVGRATDYVFRIIYPG 311
Cdd:cd15784  100 QRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEVKEEQATDYVFRIIYPG 176
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 725-893 9.15e-42

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 152.08  E-value: 9.15e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585   725 LHRIDKDVQRCDRNYWYFTTSN---LERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMGQN 801
Cdd:smart00164  47 VHQIEKDLRRTFPEHSFFQDKEgpgQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585   802 F--PSGGAMDSHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAArrisSEHFVL 879
Cdd:smart00164 127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAE----GSDFLF 201

                          170
                   ....*....|....
gi 568976585   880 FIALALVEAYREII 893
Cdd:smart00164 202 RVALALLKLHRDVL 215
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 18-152 2.16e-86

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 274.12  E-value: 2.16e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAEDICHKVQELQQQAE 97
Cdd:cd17704    1 KEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568976585  98 GRKPSGGSQEALRKQGSTGGKAPALSPQALKHIWVRTALMEKVLDRVVQYLAENC 152
Cdd:cd17704   81 GRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQYIVDNC 135
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 163-311 1.45e-77

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 250.33  E-value: 1.45e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585 163 PQKTGLPPAPV---STWSLCTRTQEHACSMART----TCWCSRVYWDYALVVPFSQIVCIHCHQQ-KSGGTLVLVSQDGI 234
Cdd:cd15784   20 PIKGYLSLHQTgrgNLTLKWTPNQLMNGSSQASsaksNSLDSSVYWDYALSVNLDDIVYIHCHQQdDSGGTVVLVGQDGV 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568976585 235 QRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSIDVEELGVGRATDYVFRIIYPG 311
Cdd:cd15784  100 QRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEVKEEQATDYVFRIIYPG 176
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 725-893 9.15e-42

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 152.08  E-value: 9.15e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585   725 LHRIDKDVQRCDRNYWYFTTSN---LERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMGQN 801
Cdd:smart00164  47 VHQIEKDLRRTFPEHSFFQDKEgpgQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585   802 F--PSGGAMDSHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAArrisSEHFVL 879
Cdd:smart00164 127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAE----GSDFLF 201

                          170
                   ....*....|....
gi 568976585   880 FIALALVEAYREII 893
Cdd:smart00164 202 RVALALLKLHRDVL 215
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 200-279 2.04e-32

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 123.01  E-value: 2.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  200 YWDYALVVPFSQIVCIHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKV 277
Cdd:pfam12068  68 PWSWAINVNVKELKYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKL 147


                  ..
gi 568976585  278 FP 279
Cdd:pfam12068 148 FP 149
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 726-893 4.60e-28

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 111.58  E-value: 4.60e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  726 HRIDKDVQRCDRNYWYFTTS-NLERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKR------M 798
Cdd:pfam00566  10 EQIEKDVPRTFPHSFFFDNGpGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENyllrdfY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  799 GQNFPSggaMDSHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAArriSSEHFV 878
Cdd:pfam00566  90 TPDFPG---LKRDLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLE---GEKFVL 162

                         170
                  ....*....|....*
gi 568976585  879 LFIALALVEAYREII 893
Cdd:pfam00566 163 FRVALAILKRFREEL 177
COG5210 COG5210
GTPase-activating protein [General function prediction only];
725-936 1.45e-20

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 96.41  E-value: 1.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585 725 LHRIDKDVQRCDRNYWYF---TTSNLERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMG-- 799
Cdd:COG5210  257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKNYGlp 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585 800 ----QNFPSggaMDSHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELLYEDVFAVWEVIWAarRISSE 875
Cdd:COG5210  337 gyflKNLSG---LHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSM 410

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568976585 876 HFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAERHDAQEILRIARDLVHKVQMLIDN 936
Cdd:COG5210  411 LFQLALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDILLFIED 471
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 42-152 3.06e-18

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 81.94  E-value: 3.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585   42 ALCGAVEACLLHQLRR------RAAGFLRSDKMAALFTKVGKTCPVAEDICHKVQELQQQAEGRkpsggsqealrkqgst 115
Cdd:pfam02759   1 QLCAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTPY---------------- 64

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568976585  116 ggkapalSPQALKHIWVRTALMEKVLDRVVQYLAENC 152
Cdd:pfam02759  65 -------SPDGRGRAWIRLALNEKLLDQWLKLLLSNK 94
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 18-152 2.16e-86

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 274.12  E-value: 2.16e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAEDICHKVQELQQQAE 97
Cdd:cd17704    1 KEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568976585  98 GRKPSGGSQEALRKQGSTGGKAPALSPQALKHIWVRTALMEKVLDRVVQYLAENC 152
Cdd:cd17704   81 GRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQYIVDNC 135
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 163-311 1.45e-77

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 250.33  E-value: 1.45e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585 163 PQKTGLPPAPV---STWSLCTRTQEHACSMART----TCWCSRVYWDYALVVPFSQIVCIHCHQQ-KSGGTLVLVSQDGI 234
Cdd:cd15784   20 PIKGYLSLHQTgrgNLTLKWTPNQLMNGSSQASsaksNSLDSSVYWDYALSVNLDDIVYIHCHQQdDSGGTVVLVGQDGV 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568976585 235 QRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSIDVEELGVGRATDYVFRIIYPG 311
Cdd:cd15784  100 QRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEVKEEQATDYVFRIIYPG 176
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
 18-152 1.62e-64

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


Pssm-ID: 439065  Cd Length: 177  Bit Score: 214.87  E-value: 1.62e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAEDICHKVQELQQQAE 97
Cdd:cd17703    1 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLKRRAAGFLRSNKIAALFMKVGKSFPPAEELCRKVQELEQLLE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568976585  98 GRKPSG-GSQEALRKQgstgGKAPALSPQALKHIWVRTALMEKVLDRVVQYLAENC 152
Cdd:cd17703   81 NKRNQMqGLQENVRKM----PKLPNLSPQAIKHLWIRTALFEKVLDKIVHYLVENS 132
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 18-154 8.53e-57

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 192.50  E-value: 8.53e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAEDICHKVQELQQQAE 97
Cdd:cd17687    1 KEVKQLMEEAVTRKFIHEDSSSVTSLCGAVDACLLHGLRKRALGLFRSSSTFSLLQKVAKSCPPAADILRKVQEIENLSE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568976585  98 GRKPSGGSQEALRKQgstggkaPALSPQALKHIWVRTALMEKVLDRVVQYLAENCRS 154
Cdd:cd17687   81 NKRSSSSSGSNSSNS-------HGNSSSNRKILWIRIALFEKVLDKIVDYLVENASK 130
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 725-893 9.15e-42

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 152.08  E-value: 9.15e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585   725 LHRIDKDVQRCDRNYWYFTTSN---LERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMGQN 801
Cdd:smart00164  47 VHQIEKDLRRTFPEHSFFQDKEgpgQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585   802 F--PSGGAMDSHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAArrisSEHFVL 879
Cdd:smart00164 127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAE----GSDFLF 201

                          170
                   ....*....|....
gi 568976585   880 FIALALVEAYREII 893
Cdd:smart00164 202 RVALALLKLHRDVL 215
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 200-279 2.04e-32

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 123.01  E-value: 2.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  200 YWDYALVVPFSQIVCIHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKV 277
Cdd:pfam12068  68 PWSWAINVNVKELKYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKL 147


                  ..
gi 568976585  278 FP 279
Cdd:pfam12068 148 FP 149
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 726-893 4.60e-28

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 111.58  E-value: 4.60e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  726 HRIDKDVQRCDRNYWYFTTS-NLERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKR------M 798
Cdd:pfam00566  10 EQIEKDVPRTFPHSFFFDNGpGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENyllrdfY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  799 GQNFPSggaMDSHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAArriSSEHFV 878
Cdd:pfam00566  90 TPDFPG---LKRDLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLE---GEKFVL 162

                         170
                  ....*....|....*
gi 568976585  879 LFIALALVEAYREII 893
Cdd:pfam00566 163 FRVALAILKRFREEL 177
COG5210 COG5210
GTPase-activating protein [General function prediction only];
725-936 1.45e-20

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 96.41  E-value: 1.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585 725 LHRIDKDVQRCDRNYWYF---TTSNLERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMG-- 799
Cdd:COG5210  257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKNYGlp 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585 800 ----QNFPSggaMDSHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELLYEDVFAVWEVIWAarRISSE 875
Cdd:COG5210  337 gyflKNLSG---LHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSM 410

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568976585 876 HFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAERHDAQEILRIARDLVHKVQMLIDN 936
Cdd:COG5210  411 LFQLALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDILLFIED 471
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 42-152 3.06e-18

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 81.94  E-value: 3.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585   42 ALCGAVEACLLHQLRR------RAAGFLRSDKMAALFTKVGKTCPVAEDICHKVQELQQQAEGRkpsggsqealrkqgst 115
Cdd:pfam02759   1 QLCAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTPY---------------- 64

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568976585  116 ggkapalSPQALKHIWVRTALMEKVLDRVVQYLAENC 152
Cdd:pfam02759  65 -------SPDGRGRAWIRLALNEKLLDQWLKLLLSNK 94
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 18-151 1.15e-06

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 49.35  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568976585  18 KEVKQIMEEAVTRK--------FVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSdkmaalftkvgktcpvaeDICHKV 89
Cdd:cd17671    1 KAVKELLESFADNGeaddsaalTLTDDDPVVGRLCAALEAILSHGLKPKRFGGGKV------------------SFWDFL 62

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568976585  90 QELQQQAEGRKPSGgsqeALRKQGSTGGkapALSPQALKHIWVRTALMEKVLDRVVQYLAEN 151
Cdd:cd17671   63 EALEKLLPAPSLKQ----AIRDINSLSN---VKTDDGRGRAWIRLALNEKSLESYLAALLSD 117
PH-like cd00900
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
 194-254 8.80e-05

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


Pssm-ID: 275390  Cd Length: 89  Bit Score: 42.00  E-value: 8.80e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568976585 194 CWCSRVYWDYALVVPFSQIVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCL 254
Cdd:cd00900   28 ILRDKNDGGLELSIPISDIVNVNVSPQgPSSRYLVLVLKDRGEFVGFSFPKEEDAIEISDAL 89
RUN_PLEKHM1 cd17679
RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and ...
 9-66 8.98e-03

RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and similar proteins; PLEKHM1, also called PH domain-containing family M member 1, or 162 kDa adapter protein (AP162), may act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. This model represents the RUN domain of PLEKHM1.


Pssm-ID: 439041 [Multi-domain]  Cd Length: 171  Bit Score: 37.96  E-value: 8.98e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568976585   9 KEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHI-IALCGAVEACLLHQLR----RRAAGFLRSD 66
Cdd:cd17679    1 KKSLTKELSSSVKELQLEYVSSDEVVTSSDDGaNTLCCVLEAIFLHGLKdkfiSKVSSVFSGD 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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