NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568935110|ref|XP_006534749|]
View 

volume-regulated anion channel subunit LRRC8C isoform X2 [Mus musculus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-291 2.73e-165

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 480.19  E-value: 2.73e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110    1 MQDKIICLPKRVQPAQNHSSVPNVSQAvISTTPLPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYF 80
Cdd:pfam12534  48 TQDKVVCLPCLESPPSTASLDDSYANS-LSPTQSAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYF 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110   81 PYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSGTIQ 153
Cdd:pfam12534 127 PYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  154 SGPEGNLVRSQSLKSIPEKFVVD-KSAAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAY 232
Cdd:pfam12534 207 SDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSY 286

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568935110  233 NSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTL 291
Cdd:pfam12534 287 TSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
535-725 7.05e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.76  E-value: 7.05e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 535 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 614
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 615 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 694
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568935110 695 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 725
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 378-618 7.56e-03

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 7.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  378 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIH-SAALSFLKEnLKVLSVKFDDM 456
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVElPSSIQYLNK-LEDLDMSRCEN 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  457 RELPPWMYGLR---------------------NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQA--V 513
Cdd:PLN03210  694 LEILPTGINLKslyrlnlsgcsrlksfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplM 773

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  514 VDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHC-DLERIPHAVfSLLSLQELDLKE-NNLKSIEEIVSfqhlrK 591
Cdd:PLN03210  774 TMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSGcSRLRTFPDIST-----N 847

                         250       260
                  ....*....|....*....|....*..
gi 568935110  592 LTVLKLWYNSIAYIPEHIKKLTSLERL 618
Cdd:PLN03210  848 ISDLNLSRTGIEEVPWWIEKFSNLSFL 874
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-291 2.73e-165

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 480.19  E-value: 2.73e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110    1 MQDKIICLPKRVQPAQNHSSVPNVSQAvISTTPLPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYF 80
Cdd:pfam12534  48 TQDKVVCLPCLESPPSTASLDDSYANS-LSPTQSAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYF 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110   81 PYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSGTIQ 153
Cdd:pfam12534 127 PYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  154 SGPEGNLVRSQSLKSIPEKFVVD-KSAAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAY 232
Cdd:pfam12534 207 SDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSY 286

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568935110  233 NSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTL 291
Cdd:pfam12534 287 TSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
535-725 7.05e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.76  E-value: 7.05e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 535 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 614
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 615 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 694
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568935110 695 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 725
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 394-730 8.06e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.11  E-value: 8.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 394 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELclhqcsvkihsaalsFLKENlkvlsvKFDDmrELPPWMYGLRNL 469
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYL---------------FLYQN------KLSG--PIPPSIFSLQKL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 470 EELYLV-GSLSHDISknvtlESLRDLKSLKILSIKSN--VSKIPQAVVDVSsHLQKMCVHNDGTKLVMLNNLKKMTNLTE 546
Cdd:PLN00113 287 ISLDLSdNSLSGEIP-----ELVIQLQNLEILHLFSNnfTGKIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTV 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 547 LELVHCDLE-RIPHAVFSLLSLQELDLKENNL-----KSIEEIVSFQHLR------------KLTVLKLWY-------NS 601
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRlqdnsfsgelpsEFTKLPLVYfldisnnNL 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 602 IAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELY 679
Cdd:PLN00113 441 QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELS 520

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568935110 680 FCKKLKTLKIGKNSLSVLSP-KIGNLLFLSYLDIKGNHFE-VLPPELGDCRAL 730
Cdd:PLN00113 521 SCKKLVSLDLSHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 531-717 2.89e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 531 KLVMLNNLKKMTNLTELELVHCDLERIPHaVFSLLSLQELDLKENNLKSIEeivSFQHLRKLTVLKLWYNSIAYIpEHIK 610
Cdd:cd21340   13 NITKIDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVV-EGLE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 611 KLTSLERLFFSHNKvevLPSHLFLCNKIRYLDlsyndirfippeiGVLQSLQYFSITCNKVESLpDELYFCKKLKTLKIG 690
Cdd:cd21340   88 NLTNLEELHIENQR---LPPGEKLTFDPRSLA-------------ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDAS 150

                        170       180       190
                 ....*....|....*....|....*....|
gi 568935110 691 KN---SLSVLSPKIGNLLFLSYLDIKGNHF 717
Cdd:cd21340  151 NNqisDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
542-602 2.54e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.54e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568935110  542 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSI 602
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 378-618 7.56e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 7.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  378 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIH-SAALSFLKEnLKVLSVKFDDM 456
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVElPSSIQYLNK-LEDLDMSRCEN 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  457 RELPPWMYGLR---------------------NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQA--V 513
Cdd:PLN03210  694 LEILPTGINLKslyrlnlsgcsrlksfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplM 773

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  514 VDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHC-DLERIPHAVfSLLSLQELDLKE-NNLKSIEEIVSfqhlrK 591
Cdd:PLN03210  774 TMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSGcSRLRTFPDIST-----N 847

                         250       260
                  ....*....|....*....|....*..
gi 568935110  592 LTVLKLWYNSIAYIPEHIKKLTSLERL 618
Cdd:PLN03210  848 ISDLNLSRTGIEEVPWWIEKFSNLSFL 874
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-291 2.73e-165

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 480.19  E-value: 2.73e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110    1 MQDKIICLPKRVQPAQNHSSVPNVSQAvISTTPLPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYF 80
Cdd:pfam12534  48 TQDKVVCLPCLESPPSTASLDDSYANS-LSPTQSAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYF 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110   81 PYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSGTIQ 153
Cdd:pfam12534 127 PYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSS 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  154 SGPEGNLVRSQSLKSIPEKFVVD-KSAAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAY 232
Cdd:pfam12534 207 SDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSY 286

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568935110  233 NSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTL 291
Cdd:pfam12534 287 TSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
535-725 7.05e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.76  E-value: 7.05e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 535 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 614
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 615 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 694
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568935110 695 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 725
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
468-732 1.75e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 1.75e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 468 NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTEL 547
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 548 ELVHCDLerIPHAVFSLLSLQELDLKENNlksieeivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEV 627
Cdd:COG4886   81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 628 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 707
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                        250       260
                 ....*....|....*....|....*
gi 568935110 708 SYLDIKGNHFEVLpPELGDCRALKR 732
Cdd:COG4886  231 ETLDLSNNQLTDL-PELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
463-724 2.38e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 2.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 463 MYGLRNLEELYLVGSLSHDISknvtlESLRDLKSLKILSIKSN-VSKIPqavvdvsshlqkmcvhndgtklvmlNNLKKM 541
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLP-----EELANLTNLKELDLSNNqLTDLP-------------------------EPLGNL 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 542 TNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFS 621
Cdd:COG4886  159 TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 622 HNKVEVLPShLFLCNKIRYLDLSYNDIRFIPPEIGvLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKI 701
Cdd:COG4886  237 NNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        250       260
                 ....*....|....*....|...
gi 568935110 702 GNLLFLSYLDIKGNHFEVLPPEL 724
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
309-711 5.94e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 5.94e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 309 QETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSG 388
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 389 LPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIHSAALSFLKeNLKVLSVKFDDMRELPPWMYGLRN 468
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 469 LEELYLVGSLSHDISknvtlESLRDLKSLKILSIKSN-VSKIPQAvvdvsshlqkmcvhndgtklvmlnnLKKMTNLTEL 547
Cdd:COG4886  161 LKSLDLSNNQLTDLP-----EELGNLTNLKELDLSNNqITDLPEP-------------------------LGNLTNLEEL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 548 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIvsfQHLRKLTVLKLWYNSIAYIPEhIKKLTSLERLFFSHNKVEV 627
Cdd:COG4886  211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 628 LP-SHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLF 706
Cdd:COG4886  287 LKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366


                 ....*
gi 568935110 707 LSYLD 711
Cdd:COG4886  367 LTLGL 371
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 394-730 8.06e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.11  E-value: 8.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 394 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELclhqcsvkihsaalsFLKENlkvlsvKFDDmrELPPWMYGLRNL 469
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYL---------------FLYQN------KLSG--PIPPSIFSLQKL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 470 EELYLV-GSLSHDISknvtlESLRDLKSLKILSIKSN--VSKIPQAVVDVSsHLQKMCVHNDGTKLVMLNNLKKMTNLTE 546
Cdd:PLN00113 287 ISLDLSdNSLSGEIP-----ELVIQLQNLEILHLFSNnfTGKIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTV 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 547 LELVHCDLE-RIPHAVFSLLSLQELDLKENNL-----KSIEEIVSFQHLR------------KLTVLKLWY-------NS 601
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRlqdnsfsgelpsEFTKLPLVYfldisnnNL 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 602 IAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELY 679
Cdd:PLN00113 441 QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELS 520

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568935110 680 FCKKLKTLKIGKNSLSVLSP-KIGNLLFLSYLDIKGNHFE-VLPPELGDCRAL 730
Cdd:PLN00113 521 SCKKLVSLDLSHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 496-748 1.17e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.71  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 496 SLKILSIKSNV--SKIPQAVVDVSShLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDL 572
Cdd:PLN00113 165 SLKVLDLGGNVlvGKIPNSLTNLTS-LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 573 KENNLkSIEEIVSFQHLRKLTVLKLWYNSIA-YIPEHIKKLTSLERLFFSHNKVE-VLPSHLFLCNKIRYLDLSYNDIR- 649
Cdd:PLN00113 244 VYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTg 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 650 FIPPEIGVLQSLQYFSITCNKVE-SLPDELYFCKKLKTLKIGKNSLSVLSPKI----GNL----LFLSYLDIKgnhfevL 720
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGlcssGNLfkliLFSNSLEGE------I 396

                        250       260
                 ....*....|....*....|....*...
gi 568935110 721 PPELGDCRALKRAGLvVEDALFETLPSD 748
Cdd:PLN00113 397 PKSLGACRSLRRVRL-QDNSFSGELPSE 423
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 531-717 2.89e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 531 KLVMLNNLKKMTNLTELELVHCDLERIPHaVFSLLSLQELDLKENNLKSIEeivSFQHLRKLTVLKLWYNSIAYIpEHIK 610
Cdd:cd21340   13 NITKIDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVV-EGLE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 611 KLTSLERLFFSHNKvevLPSHLFLCNKIRYLDlsyndirfippeiGVLQSLQYFSITCNKVESLpDELYFCKKLKTLKIG 690
Cdd:cd21340   88 NLTNLEELHIENQR---LPPGEKLTFDPRSLA-------------ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDAS 150

                        170       180       190
                 ....*....|....*....|....*....|
gi 568935110 691 KN---SLSVLSPKIGNLLFLSYLDIKGNHF 717
Cdd:cd21340  151 NNqisDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
542-602 2.54e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.54e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568935110  542 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSI 602
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
534-754 4.22e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 4.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 534 MLNNLKKmtNLTELELVHCDLERIPHAVFSllSLQELDLKENNLKSIeeivsfqhlrkltvlklwynsiayiPEHIKklT 613
Cdd:PRK15370 172 MRDCLKN--NKTELRLKILGLTTIPACIPE--QITTLILDNNELKSL-------------------------PENLQ--G 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 614 SLERLFFSHNKVEVLPSHLflCNKIRYLDLSYNDIRFIPPEIGvlQSLQYFSITCNKVESLPDELyfCKKLKTLKIGKNS 693
Cdd:PRK15370 221 NIKTLYANSNQLTSIPATL--PDTIQEMELSINRITELPERLP--SALQSLDLFHNKISCLPENL--PEELRYLSVYDNS 294

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568935110 694 LSVLSPKIGNllFLSYLDIKGNHFEVLPPELgdcrALKRAGLVVEDALFETLPSDVREQMK 754
Cdd:PRK15370 295 IRTLPAHLPS--GITHLNVQSNSLTALPETL----PPGLKTLEAGENALTSLPASLPPELQ 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 556-731 9.86e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 9.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 556 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIA-YIPEhiKKLTSLERLFFSHNKVE-VLPSHLF 633
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 634 LCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNK-VESLPDELYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYL 710
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYeIGGLTSLNHL 241

                        170       180
                 ....*....|....*....|..
gi 568935110 711 DIKGNHFE-VLPPELGDCRALK 731
Cdd:PLN00113 242 DLVYNNLTgPIPSSLGNLKNLQ 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 466-640 5.24e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 5.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 466 LRNLEELYLvgslSH-DISKnvtLESLRDLKSLKILSIKSNvskipqavvdvsshlqkmcvhndgtKLVMLNNLKKMTNL 544
Cdd:cd21340   45 LTNLTHLYL----QNnQIEK---IENLENLVNLKKLYLGGN-------------------------RISVVEGLENLTNL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 545 TELelvHCDLERI---------PHAVFSLL-SLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 614
Cdd:cd21340   93 EEL---HIENQRLppgekltfdPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPS 169

                        170       180
                 ....*....|....*....|....*.
gi 568935110 615 LERLFFSHNKVevlpshlflCNKIRY 640
Cdd:cd21340  170 LRELDLTGNPV---------CKKPKY 186
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 535-696 6.77e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 6.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 535 LNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL--KSIEEIVS-FQHLRKLTVLKLWYNSI-----AYIP 606
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdegvIALA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 607 EHIKKLTSLERLFFSHNKVEV-----LPSHLFLCNKIRYLDLSYNDIRFiPPEIGVLQSLQ-----------YFSITCNK 670
Cdd:COG5238  258 EALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQgnktlhtlnlaYNGIGAQG 336

                        170       180
                 ....*....|....*....|....*.
gi 568935110 671 VESLPDELYFCKKLKTLKIGKNSLSV 696
Cdd:COG5238  337 AIALAKALQENTTLHSLDLSDNQIGD 362
LRR_8 pfam13855
Leucine rich repeat;
566-625 2.14e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.14e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568935110  566 SLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSIAYI-PEHIKKLTSLERLFFSHNKV 625
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 557-623 8.06e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 8.06e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568935110 557 IPHAVFSLLSLQELDLKENNLKSieEI-VSFQHLRKLTVLKLWYNSI-AYIPEHIKKLTSLERLFFSHN 623
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
659-717 1.14e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568935110  659 QSLQYFSITCNKVESLPDE-LYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYLDIKGNHF 717
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 543-648 1.32e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110 543 NLTELELVHCDL-----ERIPHAVFSLLSLQELDLKENNLKS--IEEI-VSFQHLRKLTVLKLWYNSI-----AYIPEHI 609
Cdd:cd00116  138 ALEKLVLGRNRLegascEALAKALRANRDLKELNLANNGIGDagIRALaEGLKANCNLEVLDLNNNGLtdegaSALAETL 217

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568935110 610 KKLTSLERLFFSHNKV------EVLPSHLFLCNKIRYLDLSYNDI 648
Cdd:cd00116  218 ASLKSLEVLNLGDNNLtdagaaALASALLSPNISLLTLSLSCNDI 262
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 378-618 7.56e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 7.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  378 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIH-SAALSFLKEnLKVLSVKFDDM 456
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVElPSSIQYLNK-LEDLDMSRCEN 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  457 RELPPWMYGLR---------------------NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQA--V 513
Cdd:PLN03210  694 LEILPTGINLKslyrlnlsgcsrlksfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplM 773

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935110  514 VDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHC-DLERIPHAVfSLLSLQELDLKE-NNLKSIEEIVSfqhlrK 591
Cdd:PLN03210  774 TMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSGcSRLRTFPDIST-----N 847

                         250       260
                  ....*....|....*....|....*..
gi 568935110  592 LTVLKLWYNSIAYIPEHIKKLTSLERL 618
Cdd:PLN03210  848 ISDLNLSRTGIEEVPWWIEKFSNLSFL 874
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH