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Conserved domains on  [gi|568952506|ref|XP_006536323|]
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cadherin-related family member 5 isoform X1 [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 133-229 3.87e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 3.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506 133 TFNVSEDTKVNTTVIpetQLKATDADI--NDILVYTLqeVTPNASKFFSLEGVNYpALKLDQTLDYFKNQNMTFMLLARD 210
Cdd:cd11304    3 EVSVPENAPPGTVVL---TVSATDPDSgeNGEVTYSI--VSGNEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTATD 76

                         90
                 ....*....|....*....
gi 568952506 211 tweeNVEPSHTATATLVLN 229
Cdd:cd11304   77 ----GGGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 255-346 2.16e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 52.32  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506 255 QYSAVVPTGHKLPSPLIMspgpIYAVDGDQAINQSIIYSIIAGNTDGTFIINAHDGNLTMTKSIP--SPMKFTLLIRA-D 331
Cdd:cd11304    1 SYEVSVPENAPPGTVVLT----VSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTAtD 76

                         90
                 ....*....|....*
gi 568952506 332 QEDMAQYSVTQAIVE 346
Cdd:cd11304   77 GGGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 40-123 9.75e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 36.14  E-value: 9.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506  40 FRVEENTTVSEPLVNIFV--PDG-----LHVTLGPLSTPYAFRIEGK--DLFLNVTPDYEENSLLQADVECKrgDAVVVR 110
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtdPDSgengeVTYSIVSGNEDGLFSIDPStgEITTAKPLDREEQSSYTLTVTAT--DGGGPP 81

                         90
                 ....*....|....*..
gi 568952506 111 LE----VFVAVLDINDN 123
Cdd:cd11304   82 LSstatVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 133-229 3.87e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 3.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506 133 TFNVSEDTKVNTTVIpetQLKATDADI--NDILVYTLqeVTPNASKFFSLEGVNYpALKLDQTLDYFKNQNMTFMLLARD 210
Cdd:cd11304    3 EVSVPENAPPGTVVL---TVSATDPDSgeNGEVTYSI--VSGNEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTATD 76

                         90
                 ....*....|....*....
gi 568952506 211 tweeNVEPSHTATATLVLN 229
Cdd:cd11304   77 ----GGGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 255-346 2.16e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 52.32  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506 255 QYSAVVPTGHKLPSPLIMspgpIYAVDGDQAINQSIIYSIIAGNTDGTFIINAHDGNLTMTKSIP--SPMKFTLLIRA-D 331
Cdd:cd11304    1 SYEVSVPENAPPGTVVLT----VSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTAtD 76

                         90
                 ....*....|....*
gi 568952506 332 QEDMAQYSVTQAIVE 346
Cdd:cd11304   77 GGGPPLSSTATVTIT 91
Cadherin pfam00028
Cadherin domain;
256-346 7.48e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 7.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506  256 YSAVVPTGhklpSPLIMSPGPIYAVDGDQAINQSIIYSIIAGNTDGTFIINAHDGNLTMTKSI--PSPMKFTLLIRA-DQ 332
Cdd:pfam00028   1 YSASVPEN----APVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdrESIGEYELTVEAtDS 76

                          90
                  ....*....|....
gi 568952506  333 EDMAQYSVTQAIVE 346
Cdd:pfam00028  77 GGPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 279-355 1.88e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 1.88e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568952506   279 AVDGDQAINQSIIYSIIAGNTDGTFIINAHDGNLTMTKSIpspmkftlliraDQEDMAQYSVTqaiVEARSVTGNPL 355
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL------------DREEQPEYTLT---VEATDGGGPPL 63
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 40-123 9.75e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 36.14  E-value: 9.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506  40 FRVEENTTVSEPLVNIFV--PDG-----LHVTLGPLSTPYAFRIEGK--DLFLNVTPDYEENSLLQADVECKrgDAVVVR 110
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtdPDSgengeVTYSIVSGNEDGLFSIDPStgEITTAKPLDREEQSSYTLTVTAT--DGGGPP 81

                         90
                 ....*....|....*..
gi 568952506 111 LE----VFVAVLDINDN 123
Cdd:cd11304   82 LSstatVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 133-229 3.87e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 3.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506 133 TFNVSEDTKVNTTVIpetQLKATDADI--NDILVYTLqeVTPNASKFFSLEGVNYpALKLDQTLDYFKNQNMTFMLLARD 210
Cdd:cd11304    3 EVSVPENAPPGTVVL---TVSATDPDSgeNGEVTYSI--VSGNEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTATD 76

                         90
                 ....*....|....*....
gi 568952506 211 tweeNVEPSHTATATLVLN 229
Cdd:cd11304   77 ----GGGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 255-346 2.16e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 52.32  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506 255 QYSAVVPTGHKLPSPLIMspgpIYAVDGDQAINQSIIYSIIAGNTDGTFIINAHDGNLTMTKSIP--SPMKFTLLIRA-D 331
Cdd:cd11304    1 SYEVSVPENAPPGTVVLT----VSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTAtD 76

                         90
                 ....*....|....*
gi 568952506 332 QEDMAQYSVTQAIVE 346
Cdd:cd11304   77 GGGPPLSSTATVTIT 91
Cadherin pfam00028
Cadherin domain;
256-346 7.48e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 7.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506  256 YSAVVPTGhklpSPLIMSPGPIYAVDGDQAINQSIIYSIIAGNTDGTFIINAHDGNLTMTKSI--PSPMKFTLLIRA-DQ 332
Cdd:pfam00028   1 YSASVPEN----APVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdrESIGEYELTVEAtDS 76

                          90
                  ....*....|....
gi 568952506  333 EDMAQYSVTQAIVE 346
Cdd:pfam00028  77 GGPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 279-355 1.88e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 1.88e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568952506   279 AVDGDQAINQSIIYSIIAGNTDGTFIINAHDGNLTMTKSIpspmkftlliraDQEDMAQYSVTqaiVEARSVTGNPL 355
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL------------DREEQPEYTLT---VEATDGGGPPL 63
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 40-123 9.75e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 36.14  E-value: 9.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952506  40 FRVEENTTVSEPLVNIFV--PDG-----LHVTLGPLSTPYAFRIEGK--DLFLNVTPDYEENSLLQADVECKrgDAVVVR 110
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtdPDSgengeVTYSIVSGNEDGLFSIDPStgEITTAKPLDREEQSSYTLTVTAT--DGGGPP 81

                         90
                 ....*....|....*..
gi 568952506 111 LE----VFVAVLDINDN 123
Cdd:cd11304   82 LSstatVTITVLDVNDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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