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Conserved domains on  [gi|568925974|ref|XP_006537630|]
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transcription regulator protein BACH2 isoform X2 [Mus musculus]

Protein Classification

transcription regulator protein BACH( domain architecture ID 13033297)

transcription regulator protein BACH belongs to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-129 8.98e-85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 265.66  E-value: 8.98e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974   6 KPGSPMYVYESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTAR 85
Cdd:cd18278    1 KTESPMYVYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEEVTAR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568925974  86 GFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18278   81 GFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
bZIP_BACH cd14719
Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and ...
 639-709 7.63e-39

Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain; BACH proteins are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. In addition, they contain a BTB domain (Broad complex-Tramtrack-Bric-a-brac domain, also known as the POZ [poxvirus and zinc finger] domain) that is absent in other CNC proteins. Veterbrates contain two members, BACH1 and BACH2. BACH1 forms heterodimers with small Mafs such as MafK to function as a repressor of heme oxygenase-1 (HO-1) gene (Hmox-1) enhancers. It has also been implicated as the master regulator of breast cancer bone metastasis. The BACH1 bZIP transcription factor should not be confused with the protein originally named as BRCA1-Associated C-terminal Helicase1 (BACH1), which has been renamed BRIP1 (BRCA1 Interacting Protein C-terminal Helicase1) and also called FANCJ. BACH2 is a B-cell specific transcription factor that plays a critical role in oxidative stress-mediated apoptosis. It plays an important role in class switching and somatic hypermutation of immunoglobulin genes. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


:

Pssm-ID: 269867 [Multi-domain]  Cd Length: 71  Bit Score: 138.40  E-value: 7.63e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568925974 639 TSEQLEFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELLDNFSCLS 709
Cdd:cd14719    1 TPEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIKKLVCEKEKLLGERNQLKASMGELRENFSCLC 71
 
Name Accession Description Interval E-value
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-129 8.98e-85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 265.66  E-value: 8.98e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974   6 KPGSPMYVYESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTAR 85
Cdd:cd18278    1 KTESPMYVYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEEVTAR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568925974  86 GFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18278   81 GFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
bZIP_BACH cd14719
Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and ...
 639-709 7.63e-39

Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain; BACH proteins are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. In addition, they contain a BTB domain (Broad complex-Tramtrack-Bric-a-brac domain, also known as the POZ [poxvirus and zinc finger] domain) that is absent in other CNC proteins. Veterbrates contain two members, BACH1 and BACH2. BACH1 forms heterodimers with small Mafs such as MafK to function as a repressor of heme oxygenase-1 (HO-1) gene (Hmox-1) enhancers. It has also been implicated as the master regulator of breast cancer bone metastasis. The BACH1 bZIP transcription factor should not be confused with the protein originally named as BRCA1-Associated C-terminal Helicase1 (BACH1), which has been renamed BRIP1 (BRCA1 Interacting Protein C-terminal Helicase1) and also called FANCJ. BACH2 is a B-cell specific transcription factor that plays a critical role in oxidative stress-mediated apoptosis. It plays an important role in class switching and somatic hypermutation of immunoglobulin genes. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269867 [Multi-domain]  Cd Length: 71  Bit Score: 138.40  E-value: 7.63e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568925974 639 TSEQLEFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELLDNFSCLS 709
Cdd:cd14719    1 TPEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIKKLVCEKEKLLGERNQLKASMGELRENFSCLC 71
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 27-133 9.64e-33

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 121.98  E-value: 9.64e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974   27 LNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLP-EEVTARGFGPLLQFAYTAKlLLSREN 105
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITlDDVSPEDFEALLEFMYTGK-LISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 568925974  106 IREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 38-133 1.66e-23

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 95.45  E-value: 1.66e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974    38 DVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDL--VVSLPEeVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEF 115
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDksEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 568925974   116 LRMHNLEDSCFSFLQTQL 133
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
BRLZ smart00338
basic region leucin zipper;
644-707 1.79e-14

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 68.74  E-value: 1.79e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568925974   644 EFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELLDNFSC 707
Cdd:smart00338   2 EDEKRRRRRERNREAARRSRERKKAEIEELERKVEQLEAENERLKKEIERLRRELEKLKSELEE 65
bZIP_Maf pfam03131
bZIP Maf transcription factor; Maf transcription factors contain a conserved basic region ...
 616-691 2.08e-11

bZIP Maf transcription factor; Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.


Pssm-ID: 427158 [Multi-domain]  Cd Length: 92  Bit Score: 60.82  E-value: 2.08e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568925974  616 FPVDQITDLPRNDFQMMIKmhKLTSEQLEFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSER 691
Cdd:pfam03131   1 LSDEELLSMSVREFNRFLR--GLTEEEVIRLKQRRRRLKNRGYAQSCRKRRLQQKESLEKERSELREQLERLVQEL 74
PHA02713 PHA02713
hypothetical protein; Provisional
 14-130 8.71e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 46.16  E-value: 8.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  14 YESTVHCANILLGLNDQRKKDILCDVTLIV-ERKEFRAHRAVLAACSEYFWQALvgqTKDDLVVSLPEEVTARGFGP--- 89
Cdd:PHA02713   3 IDDIKHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLF---TTPMIIRDLVTRVNLQMFDKdav 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568925974  90 --LLQFAYTAKllLSRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:PHA02713  80 knIVQYLYNRH--ISSMNVIDVLKCADYLLIDDLVTDCESYIK 120
 
Name Accession Description Interval E-value
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-129 8.98e-85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 265.66  E-value: 8.98e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974   6 KPGSPMYVYESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTAR 85
Cdd:cd18278    1 KTESPMYVYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEEVTAR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568925974  86 GFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18278   81 GFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-129 4.46e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 193.74  E-value: 4.46e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  11 MYVYESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTARGFGPL 90
Cdd:cd18277    2 VFAYESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADAELNITLPEEVTVKGFEPL 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568925974  91 LQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18277   82 IQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-129 1.45e-55

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 186.13  E-value: 1.45e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  36 LCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEF 115
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLVITLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                         90
                 ....*....|....
gi 568925974 116 LRMHNLEDSCFSFL 129
Cdd:cd18955   81 LGVHNIEKACFDFL 94
bZIP_BACH cd14719
Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and ...
 639-709 7.63e-39

Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain; BACH proteins are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. In addition, they contain a BTB domain (Broad complex-Tramtrack-Bric-a-brac domain, also known as the POZ [poxvirus and zinc finger] domain) that is absent in other CNC proteins. Veterbrates contain two members, BACH1 and BACH2. BACH1 forms heterodimers with small Mafs such as MafK to function as a repressor of heme oxygenase-1 (HO-1) gene (Hmox-1) enhancers. It has also been implicated as the master regulator of breast cancer bone metastasis. The BACH1 bZIP transcription factor should not be confused with the protein originally named as BRCA1-Associated C-terminal Helicase1 (BACH1), which has been renamed BRIP1 (BRCA1 Interacting Protein C-terminal Helicase1) and also called FANCJ. BACH2 is a B-cell specific transcription factor that plays a critical role in oxidative stress-mediated apoptosis. It plays an important role in class switching and somatic hypermutation of immunoglobulin genes. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269867 [Multi-domain]  Cd Length: 71  Bit Score: 138.40  E-value: 7.63e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568925974 639 TSEQLEFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELLDNFSCLS 709
Cdd:cd14719    1 TPEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIKKLVCEKEKLLGERNQLKASMGELRENFSCLC 71
bZIP_CNC cd14698
Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding ...
 642-709 2.50e-33

Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain; CNC proteins form a subfamily of Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. This subfamily includes Drosophila Cnc and four vertebrate counterparts, NFE2 (nuclear factor, erythroid-derived 2), NFE2-like 1 or NFE2-related factor 1 (NFE2L1 or Nrf1), NFE2L2 (or Nrf2), and NFE2L3 (or Nrf3). It also includes BACH1 and BACH2, which contain an additional BTB domain (Broad complex###Tramtrack###Bric-a-brac domain, also known as the POZ [poxvirus and zinc finger] domain). CNC proteins function during development and/or contribute in maintaining homeostasis during stress responses. In flies, Cnc functions both in development and in stress responses. In vertebrates, several CNC proteins encoded by distinct genes show varying functions and expression patterns. NFE2 is required for the proper development of platelets while the three Nrfs function in stress responses. Nrf2, the most extensively studied member of this subfamily, acts as a xenobiotic-activated receptor that regulates the adaptive response to oxidants and electrophiles. BACH1 forms heterodimers with small Mafs such as MafK to function as a repressor of heme oxygenase-1 (HO-1) gene (Hmox-1) enhancers. BACH2 is a B-cell specific transcription factor that plays a critical role in oxidative stress-mediated apoptosis. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269846 [Multi-domain]  Cd Length: 68  Bit Score: 122.36  E-value: 2.50e-33
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568925974 642 QLEFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELLDNFSCLS 709
Cdd:cd14698    1 QLQLIRDIRRRGKNKVAAQNCRKRKLDQISTLEDEVDELKEEKEKLLKERDELEAETREMKDKYSQLY 68
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-134 7.95e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 123.05  E-value: 7.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  18 VHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEE--------VTARGFGP 89
Cdd:cd18228    1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPAGkcvldlhhVTVTGFAP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568925974  90 LLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLL 134
Cdd:cd18228   81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSIL 125
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 27-133 9.64e-33

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 121.98  E-value: 9.64e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974   27 LNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLP-EEVTARGFGPLLQFAYTAKlLLSREN 105
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITlDDVSPEDFEALLEFMYTGK-LISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 568925974  106 IREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-128 4.93e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 108.81  E-value: 4.93e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDL-VVSLPEEVTARGFGPLLQFAYTA 97
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVsVINLDPEIEPEGFRILLDFMYTS 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSCFSF 128
Cdd:cd18215   82 RLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-130 4.39e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 106.48  E-value: 4.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDL-VVSLPEEVTARGFGPLLQFAYTA 97
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVsVLTLPSGLEARGFQLLLDFMYTS 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:cd18332   82 RLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-129 8.42e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 105.71  E-value: 8.42e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  17 TVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDL-VVSLPEEVTARGFGPLLQFAY 95
Cdd:cd18331    5 TRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLsVINLDPEINPEGFNILLDFMY 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568925974  96 TAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18331   85 TSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 3.97e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 100.93  E-value: 3.97e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKD--DLVVSLpEEVTARGFGPLLQFAYT 96
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMREssQDEIEL-KGVSAKGLKHILDFAYT 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568925974  97 AKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18255   80 SELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAM 116
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-128 1.45e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 99.23  E-value: 1.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQtKDdlVVSLpEEVTARGFGPLLQFAYTAK 98
Cdd:cd18206    5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQ-KD--VVHL-DISNAAGLGQVLEFMYTAK 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 568925974  99 LLLSRENIREVIRCAEFLRMHNLEDSCFSF 128
Cdd:cd18206   81 LSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-116 5.36e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 96.47  E-value: 5.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  36 LCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDL--VVSLPeEVTARGFGPLLQFAYTAKLLLSRENIREVIRCA 113
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSssEIELD-DVSPEAFEALLDYIYTGELELSEENVEELLAAA 79


                 ...
gi 568925974 114 EFL 116
Cdd:cd18186   80 DKL 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 38-133 1.66e-23

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 95.45  E-value: 1.66e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974    38 DVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDL--VVSLPEeVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEF 115
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDksEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 568925974   116 LRMHNLEDSCFSFLQTQL 133
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 3.71e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 94.82  E-value: 3.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVGQTKDDLVVSLPEEVTARGFGPLLQFAYTAK 98
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYF-GAQYKDTEDNIVFLDQSQVSADGFQKLLEFIYTGN 79

                         90       100
                 ....*....|....*....|....*..
gi 568925974  99 LLLSRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18217   80 LNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-121 1.11e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 93.71  E-value: 1.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  16 STVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFW-----QALVGQTkddlvVSLPEEVTARGFGPL 90
Cdd:cd18212    3 SKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSmmfadEGEVGQS-----IYMLEGMVAETFGAL 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568925974  91 LQFAYTAKLLLSRENIREVIRCAEFLRMHNL 121
Cdd:cd18212   78 LEFIYTGCLQVGEKSLEQILATAQFLKVNDL 108
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-129 4.36e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 92.31  E-value: 4.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALV-GQTKDDLVVSLPEEVTARGFGPLLQFAYTA 97
Cdd:cd18326    8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTsGAVVDQQNVYEIDFVSAEALTALLDFAYTA 87

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18326   88 TLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-133 5.40e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 92.12  E-value: 5.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  16 STVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQT--KDDLVVSLpEEVTARGFGPLLQF 93
Cdd:cd18242    1 TNSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMseKGKSEVEL-QGLTASTMEILLDF 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568925974  94 AYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18242   80 VYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQL 119
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-133 1.26e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 91.28  E-value: 1.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  17 TVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYF--WQALVGQTKDDLVVSLPEEVTARGFGPLLQFA 94
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFktLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFM 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568925974  95 YTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18230   82 YSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAAL 120
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-132 2.63e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 90.03  E-value: 2.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  27 LNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVgqtKDDLVVSLPEEVTARGFGP-----LLQFAYTAKLLL 101
Cdd:cd18247   10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYF-HAMF---THDMVESKQDEITMQGIEPsaleaLINFAYSGRIAI 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568925974 102 SRENIREVIRCAEFLRMHNLEDSCFSFLQTQ 132
Cdd:cd18247   86 DTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-125 1.23e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 88.48  E-value: 1.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  12 YVYESTVHCANILLGLNDQRKKD-ILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPE--EVTARGFG 88
Cdd:cd18207    2 YTYQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEmhTISSKVFG 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568925974  89 PLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18207   82 DILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDIC 118
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-133 1.40e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 87.87  E-value: 1.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  18 VHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGqtkdDLVVSLPE-----EVTARGFGPLLQ 92
Cdd:cd18235    3 QHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTG----DLSESRANrvtlqDVDGKALLLLID 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568925974  93 FAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18235   79 YVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQL 119
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-130 1.72e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 87.61  E-value: 1.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALV-GQTKDDLVVSLPEEVTARGFGPLLQFAYTA 97
Cdd:cd18198    8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTsGAVVDQQNVYEIDFVSPEALTALLEFAYTA 87

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:cd18198   88 TLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-130 4.45e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 86.82  E-value: 4.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQT--KDDLVVSLPEEVTARGF------GPL 90
Cdd:cd18327    8 HSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGggSGDLGAGGGQDVCELDFvgpealGAL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568925974  91 LQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:cd18327   88 LEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-130 8.72e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 85.70  E-value: 8.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALV-GQTKDDLVVSLPEEVTARGFGPLLQFAYTA 97
Cdd:cd18328    8 HSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTaGTLADQPYVYEIDFVTPEALSAILEFAYTS 87

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:cd18328   88 TLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-139 1.16e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 85.64  E-value: 1.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQT-KDDLVVSLPEEVTARGFGPLLQFAYTA 97
Cdd:cd18194    6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLdKRDLVRLNSDIVTAPAFGLLLDFMYEG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNREDG 139
Cdd:cd18194   86 RLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKALAEADS 127
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-118 1.38e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 85.05  E-value: 1.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSlpEEVTARGFGPLLQFAYTAK 98
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEI--EGVSNMAFRHLIEFTYTAK 78

                         90       100
                 ....*....|....*....|.
gi 568925974  99 LLL-SRENIREVIRCAEFLRM 118
Cdd:cd18221   79 LMVqGEEEANDVWKAAEYLQM 99
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-136 1.39e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 85.40  E-value: 1.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  15 ESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVGQTkddLVVSLPEEV-----TARGFGP 89
Cdd:cd18261    7 QSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYF-RAMFSLC---MVESEADEVnlhgvTSLGLKQ 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568925974  90 LLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLqTQLLNR 136
Cdd:cd18261   83 ALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYL-IQELNS 128
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 2.50e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 84.62  E-value: 2.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYF---WQALVGQTKDDLVVSLPEEVTARGFGPLLQFAY 95
Cdd:cd18201    4 YCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFktlYCFTNKESCDQTTVTHLDVVAVQGFSVILDFMY 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568925974  96 TAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18201   84 SGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 2.54e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 84.13  E-value: 2.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQ---TKDDLVVSLpEEVTARGFGPLLQFAY 95
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKgavSSHEAVVDL-SGFCKSSFLPLLEFAY 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 568925974  96 TAKLLLSRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18202   81 TSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
bZIP_NFE2-like cd14720
Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar ...
 642-709 4.88e-19

Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain; This subfamily is composed of NFE2 and NFE2-like proteins including NFE2-like 1 or NFE2-related factor 1 (NFE2L1 or Nrf1), NFE2L2 (or Nrf2), and NFE2L3 (or Nrf3). These are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. NFE2 functions in development; it is required for the proper development of platelets. The three Nrfs function in stress responses. Nrf2, the most extensively studied member of this subfamily, acts as a xenobiotic-activated receptor that regulates the adaptive response to oxidants and electrophiles. As the master regulator of the antioxidant defense pathway, it plays roles in the biology of inflammation, obesity, and cancer. Nrf1 is an essential protein that binds to the antioxidant response element (ARE) and is also involved in regulating oxidative stress. In addition, it also regulates genes involved in cell and tissue differentiation, inflammation, and hepatocyte homeostasis. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269868 [Multi-domain]  Cd Length: 68  Bit Score: 81.58  E-value: 4.88e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568925974 642 QLEFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELLDNFSCLS 709
Cdd:cd14720    1 QLALIRDIRRRGKNKVAAQNCRKRKLDNIVGLEDEVEQLQRQREKLLREKAENAKSLREMKQKLNDLY 68
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-136 5.35e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 83.46  E-value: 5.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQaLVGQTKDD---LVVSLpEEVTARGFGPLLQFAY 95
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFE-LFSSDSDGesiLTVKL-DGLDPDAVEVLVNYAY 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568925974  96 TAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNR 136
Cdd:cd18306   79 TSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQ 119
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-138 6.43e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 83.55  E-value: 6.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEE-VTARGFGPLLQFAYTA 97
Cdd:cd18325    6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDiVTAPAFSLLLEFMYEG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNRED 138
Cdd:cd18325   86 KLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDKELCSEE 126
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 1.03e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 82.92  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGqtkdDLVVSLPEEVTARGFGP-----LLQF 93
Cdd:cd18237    4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTS----NMTESKSSEVELKDAEPdiielLVEF 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568925974  94 AYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18237   80 AYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQL 119
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-129 1.96e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 81.70  E-value: 1.96e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDD---LVVSLpEEVTARGFGPLLQFAY 95
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTgrpSTASF-DVFSSDAFSIILDFVY 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568925974  96 TAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18199   80 SGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 2.38e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 81.40  E-value: 2.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVGQTKDDLVVSLpEEVTARGFGPLLQFAYTAK 98
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYF-RNILKKDPSLQRVEL-NDISPLGLATVITYAYTGK 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568925974  99 LLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18260   79 LTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEM 113
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-130 3.13e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 80.85  E-value: 3.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  23 ILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALV----GQTKDDLVVSLPEEVTARGFGPLLQFAYTAK 98
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYF-RAKLnynpPKDDGSTYKIELEGISVEVMEEILDYIYTGQ 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568925974  99 LLLSRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:cd18245   80 IKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-133 3.40e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 81.35  E-value: 3.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  17 TVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLV--VSLpEEVTARGFGPLLQFA 94
Cdd:cd18250    2 PAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRAdrVVL-HGVSAEILGLLLDFS 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568925974  95 YTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18250   81 YTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRL 119
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-133 4.22e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 80.92  E-value: 4.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  27 LNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLP-EEVTARGFGPLLQFAYTAKLLLSREN 105
Cdd:cd18339   12 MNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEiKDVDGQTLSKLIDYIYTAEIEVTEEN 91

                         90       100
                 ....*....|....*....|....*...
gi 568925974 106 IREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18339   92 VQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-129 6.59e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 80.25  E-value: 6.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  16 STVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDlvvSLPEEVTARGFGP-----L 90
Cdd:cd18329    1 ISSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKET---GQPTVATFDVFSPdtftiI 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568925974  91 LQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18329   78 LDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 7.53e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 80.14  E-value: 7.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLP-EEVTARGFGPLLQFAYTA 97
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQiHGVEPDIFHILLDFIYTG 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18256   83 VVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQL 118
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-138 8.07e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 80.26  E-value: 8.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQ-TKDDLVVSLPEEVTARGFGPLLQFAYTA 97
Cdd:cd18323    6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQlDKRDLVCINNEIVTAPAFSLLLEFMYEG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNRED 138
Cdd:cd18323   86 RLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQARALAEAD 126
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-133 9.68e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 79.73  E-value: 9.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  27 LNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLP-EEVTARGFGPLLQFAYTAKLLLSREN 105
Cdd:cd18338   12 MNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRiKEVDGWTLKMLIDYVYTAEIQVTEEN 91

                         90       100
                 ....*....|....*....|....*...
gi 568925974 106 IREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18338   92 VQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-129 2.53e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 78.73  E-value: 2.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVgqTKDDLVVSLPEEVTARGFGPLLQFAYTAK 98
Cdd:cd18216    3 HATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYF-KSLV--LHDNLIHLDQDMVSPTVFQQILDFIYTGK 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568925974  99 LLLSRE---NIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18216   80 LLDSLFeepNLSEVLAAANYLQLPDLAALCRSKL 113
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-128 2.54e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 78.26  E-value: 2.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVGQTKdDLVVSLPEEVtARGFGPLLQFAYTAK 98
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFF-QSLYGDGT-SGSVVLPESF-AEVFGLLLDFFYTGE 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 568925974  99 LLLSRENIREVIRCAEFLRMHNLEDSCFSF 128
Cdd:cd18232   78 LALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-129 2.83e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 78.43  E-value: 2.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  24 LLG-LNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDD---LVVSLpEEVTARGFGPLLQFAYTAKL 99
Cdd:cd18330    5 LLGeLNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSgrhSTASL-DIVTSEAFSIILDFLYSGKL 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 568925974 100 LLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18330   84 DLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 5.24e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 78.54  E-value: 5.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQ-TKDDLVVSLPEEVTARGFGPLLQFAYTA 97
Cdd:cd18324    6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQlDKRDIVHLNSDIVTAPAFALLLEFMYEG 85

                         90       100
                 ....*....|....*....|....*...
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18324   86 KLQFKDLPIEDVLAAASYLHMYDIVKVC 113
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-133 9.11e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 77.50  E-value: 9.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  17 TVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLP-EEVTARGFGPLLQFAY 95
Cdd:cd18265    4 PCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEiQKVSAAAMEVLLDYMY 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568925974  96 TAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18265   84 GGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQL 121
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-135 1.03e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 76.88  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  27 LNDQR--KKDiLCDV--TLIVERKEFRAHRAVLAACSEYFwQALVGQTKDDLVVSLP-EEVTARGFGPLLQFAYTAKLLL 101
Cdd:cd18231    4 LNEQRlfQPD-LCDVdiVLVRQRSTFPAHKGVLAAYSQFF-HSLFTQNKQLQRVELSlEALTSQGLQQILNFIYTSKLLV 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568925974 102 SRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLN 135
Cdd:cd18231   82 NSCNVQDVLNAAAVLQMNDIAASCQELIDSRSLS 115
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 1.92e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 76.16  E-value: 1.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVgqTKDDLVVSLPEEVTARGFGPLLQFAYTAK 98
Cdd:cd18334    4 HAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYF-KSLV--LHDNLINLDTDMVNPTVFRQILDFIYTGK 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568925974  99 LLLS----RENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18334   81 LLTSdqpgEQNFNALLTAASYLQLHDLAALC 111
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 2.84e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 76.41  E-value: 2.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGqtkdDLVVSLPEEVTARGFGP-----LLQF 93
Cdd:cd18259   15 HPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTG----DFVESISARVEIKDVDPavmesLIDF 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568925974  94 AYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18259   91 AYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQI 130
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-129 4.23e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 74.88  E-value: 4.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  21 ANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFW-QALVgqtKDDLVVSLPEEVTARGFGPLLQFAYTAKL 99
Cdd:cd18210    6 SSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHdQVLL---KNMSSISLPGVMDPGAFESVLASAYTGKL 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 568925974 100 LLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18210   83 TMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 4.33e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 74.88  E-value: 4.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQ--TKDDLVVSLpEEVTARGFGPLLQFAYT 96
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNlsEKENSEVEF-QCIDETALQAIVEYAYT 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568925974  97 AKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18257   80 GTVFISQATVESLLPAANLLQIKLVLKECCDFLESQL 116
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-133 7.44e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 75.41  E-value: 7.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  11 MYVYESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKD--DLVVSLPEEVTARGFG 88
Cdd:cd18267   15 IYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKEsqDSEVNFHDSIHPEVLE 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568925974  89 PLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18267   95 LLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNL 139
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-130 1.36e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 73.82  E-value: 1.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  23 ILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFW-QALVgqtKDDLVVSLPEEVTARGFGPLLQFAYTAKLLL 101
Cdd:cd18227   12 ILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCdQVLL---KNSRRIVLPDVMNPRVFENILLSCYTGRLVL 88

                         90       100
                 ....*....|....*....|....*....
gi 568925974 102 SRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:cd18227   89 PAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-101 1.83e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 73.39  E-value: 1.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQT---------------KDDLVVSLPeEVT 83
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLplgaaavaaapgatqSPERVLELP-GVK 79

                         90
                 ....*....|....*...
gi 568925974  84 ARGFGPLLQFAYTAKLLL 101
Cdd:cd18195   80 AGVFSDVLNFIYSSRVAL 97
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 2.17e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 73.91  E-value: 2.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  14 YESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLP-EEVTARGFGPLLQ 92
Cdd:cd18246   17 HNSKRHYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTlHDIDPQALEQLVQ 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568925974  93 FAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18246   97 YAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 137
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 2.61e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 72.95  E-value: 2.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVgqtKDDLVVSLPEEVTARGFGP-----LLQF 93
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYF-RAMF---CNDHRESREMLVEINGILAeamdcFLQY 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568925974  94 AYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18253   77 VYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQL 116
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 3.54e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 72.92  E-value: 3.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  14 YESTVHCANILLGLNDQRKKDILCDVTLIVERKE--FRAHRAVLAACSEYFWQALVGQTKD-DLVVSLPEEVTARGFGPL 90
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDetFPVHRAMMASASDYFKAMFTGGMKEqELMCIKLHGVSKIGLKNI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568925974  91 LQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18239   81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGV 123
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-130 3.67e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 72.23  E-value: 3.67e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYF---WQALVGQTKDDLVVSLPEevtARGFGPLLQFAY 95
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFrslFQNSSSQKNDVFHLDIKN---VGGIGQILDFMY 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568925974  96 TAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:cd18233   78 TSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 4.12e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 72.41  E-value: 4.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVE----RKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLP-EEVTARGFGPLLQF 93
Cdd:cd18248    4 HTKEAFQIMNELRLSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPiEGVHPCVMSRLIEF 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568925974  94 AYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18248   84 AYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 36-116 7.41e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 70.27  E-value: 7.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  36 LCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDL-VVSLPeEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAE 114
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHpVIILP-DVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                 ..
gi 568925974 115 FL 116
Cdd:cd18315   80 LL 81
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 1.07e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 71.58  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDL--VVSLPEEVTARGFGPLLQFAYT 96
Cdd:cd18254    5 HPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLdsTVNFHDSLHPEVLELLLDFAYS 84

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568925974  97 AKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18254   85 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 121
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-124 1.07e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 71.01  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  16 STVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPE-EVTARGFGPLLQFA 94
Cdd:cd18192    1 RPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNmKISAECFDLILQFM 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 568925974  95 YTAKLLLSRENIREVIRCAEFLRMHNLEDS 124
Cdd:cd18192   81 YLGKIMTAPSDFEQLKVAMNYLQLYYIPEC 110
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-134 1.29e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 71.23  E-value: 1.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVGQTKDDLVVSL----PEEVTARGFGPLLQFA 94
Cdd:cd18196    4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHF-RALFTVAEGDQTMNMiqldSEVVTAEAFAALIDMM 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568925974  95 YTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLL 134
Cdd:cd18196   83 YTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTL 122
BRLZ smart00338
basic region leucin zipper;
644-707 1.79e-14

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 68.74  E-value: 1.79e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568925974   644 EFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELLDNFSC 707
Cdd:smart00338   2 EDEKRRRRRERNREAARRSRERKKAEIEELERKVEQLEAENERLKKEIERLRRELEKLKSELEE 65
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-128 1.99e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 70.45  E-value: 1.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  22 NILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALvgQTKDDLVVSLPEEVTARGFGPLLQFAYTAKLLL 101
Cdd:cd18290   13 SILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF--NSSRSAVVELPAAVQPQSFQQILSFCYTGRLSM 90

                         90       100
                 ....*....|....*....|....*..
gi 568925974 102 SRENIREVIRCAEFLRMHNLEDSCFSF 128
Cdd:cd18290   91 NVGDQFLLMYTAGFLQIQEIMEKGTEF 117
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-123 2.11e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 70.20  E-value: 2.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQT--KDDLVVSLPeEVTARGFGPLLQFAYT 96
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEiwISSHVLELP-DLKAEVFAEILNFIYS 79

                         90       100
                 ....*....|....*....|....*...
gi 568925974  97 AKLLLSR-ENIREVIRCAEFLRMHNLED 123
Cdd:cd18223   80 SKVVVKRqETVTDLVAAGKKLGITFLEN 107
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-133 2.23e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 70.60  E-value: 2.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  16 STVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDD--LVVSLPeEVTARGFGPLLQF 93
Cdd:cd18264    8 SKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESkaRVIHLP-VVSAAGLQRVLDF 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568925974  94 AYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18264   87 IYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNL 126
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-121 2.74e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 70.44  E-value: 2.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  22 NILLG-LNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLvvSLPEEVTARGFGPLLQFAYTAKLL 100
Cdd:cd18289   14 NTVLGcLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAF--ELPATVPPACFQQILSFCYTGKLT 91

                         90       100
                 ....*....|....*....|.
gi 568925974 101 LSRENIREVIRCAEFLRMHNL 121
Cdd:cd18289   92 MAASEQLVVMYTAGFLQIQHI 112
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 2.93e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 70.27  E-value: 2.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  14 YESTVHCANILLGLNDQRKKDILCDVTLIVER---KEFRAHRAVLAACSEYFWQALVGQTKDDLV--VSLPEEVTARGFG 88
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGaggREFRAHRSVLAAATEYFTPLLSGQFSESRSgrVEMRKWSSEPGPD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568925974  89 P-----LLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18241   81 PdtveaVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKL 130
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 3.64e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 69.79  E-value: 3.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  14 YESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQtkddLVVSLPEEVTARGFGP---- 89
Cdd:cd18249    1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGE----LAESRQTEVTIRDIDErame 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568925974  90 -LLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18249   77 lLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQL 121
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-133 4.47e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 69.28  E-value: 4.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  27 LNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQ--TKDDLVVSLPeEVTARGFGPLLQFAYTAKLLLSRE 104
Cdd:cd18240    8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGwnETEKKVYKIP-GVSPEMMELIIEYAYTRTVPITAE 86

                         90       100
                 ....*....|....*....|....*....
gi 568925974 105 NIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18240   87 NVEELLPAADQFNIMGIVKACCDFLEDQL 115
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-116 1.32e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 67.55  E-value: 1.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  17 TVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQ--ALVGQtkddlVVSLpEEVTARGFGPLLQFA 94
Cdd:cd18219    2 TQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQlfSVAGQ-----VVEL-NFIRADIFAEILNYI 75

                         90       100
                 ....*....|....*....|...
gi 568925974  95 YTAKLLLSREN-IREVIRCAEFL 116
Cdd:cd18219   76 YSSKIVRVRSDlLEELIKSGQLL 98
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-133 1.34e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 67.39  E-value: 1.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  36 LCDVTLIVERKEFRAHRAVLAACSEYFwQALVGqtkDDLVVSLPEEVTARGFGP-----LLQFAYTAKLLLSRENIREVI 110
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYF-AAMFT---NDVREATEEEIKLKDVDPdalwtLVQYCYTGRLELKEDNVESLL 76

                         90       100
                 ....*....|....*....|...
gi 568925974 111 RCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18234   77 ATACLLQLSEVVEACCGFLMKQL 99
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-133 2.04e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 67.69  E-value: 2.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  23 ILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVGQTKDD--------LVVSlpeEVTARGFGPLLQFA 94
Cdd:cd18258    4 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYF-KDLIKRSSRDsgggekleLTMS---NINADVLELLLEFV 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568925974  95 YTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18258   80 YTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQL 118
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-133 2.05e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 68.06  E-value: 2.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  13 VYESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVG--QTKDDLVVSLpEEVTARGFGPL 90
Cdd:cd18244    7 VYNSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTAdmRERDQDKIHL-KGLTATGFSHV 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568925974  91 LQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18244   86 LQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKI 128
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-130 2.17e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 67.19  E-value: 2.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVvsLPEEVTARGFGPLLQFAYTAK 98
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNCLV--LPSVIEAAAFENLLQLIYSGR 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568925974  99 LLLSRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:cd18200   79 LTLCMDALPSHLLVASGLQMWQVVDRCSELLK 110
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-133 4.00e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 66.54  E-value: 4.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  27 LNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQAL----VGQTKDDLVVSlpEEVTARGFGPLLQFAYTAKLLLS 102
Cdd:cd18238    6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYF-RAMftseMAESKQDSITI--KDIDEEAVELLVDFAYTGKLTLT 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568925974 103 RENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18238   83 VDNVQSLLYAASLLQVEEVAKACCEFMKDHL 113
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 5.71e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 66.08  E-value: 5.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVgqTKDDLVVSLPEEVTARGFGPLLQFAYTAK 98
Cdd:cd18333    4 HSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYL-KSLV--VHDNLINLDHEMVSPGIFRLILDYIYTGR 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568925974  99 LL----LSRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18333   81 LSegdpGSEQNLGAVLAAASYLQIPDLVALC 111
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-134 6.81e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 66.42  E-value: 6.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  13 VYESTVHCANILLGLNDQRKKDILCDVTLIVE----RKEFRAHRAVLAACSEYFWQALVGQTKDD---LVVSLpEEVTAR 85
Cdd:cd18211    2 LLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEhqgsKEEFSAHKAVLAASSKYFKEVFLNEKISDgknTNVML-NEIYTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568925974  86 GFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSfLQTQLL 134
Cdd:cd18211   81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQ-LKKQML 128
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-138 7.11e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 66.45  E-value: 7.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  13 VYESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQAL-VG-----QTKDDLVVSlpeevTARG 86
Cdd:cd18266    2 VYRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtIGmreahQKEVELVGA-----SYIG 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568925974  87 FGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLlnRED 138
Cdd:cd18266   77 LKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEV--SEE 126
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 7.25e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 66.37  E-value: 7.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKD--DLVVSLPEEVTARGFGPLLQFAYT 96
Cdd:cd18956    6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGgrDTVRLNGDIVTAPAFGRLLDFMYE 85

                         90       100
                 ....*....|....*....|....*....
gi 568925974  97 AKLLLSRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18956   86 GRLDLRSLPVEDVLAAASYLHMYDIVKVC 114
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-125 7.82e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 65.97  E-value: 7.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  24 LLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDD---LVVSLPeEVTARGFGPLLQFAYTAKLL 100
Cdd:cd18293    3 FLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAgqkVVLELQ-GLKAHTLLKLVDFLYTSELE 81

                         90       100
                 ....*....|....*....|....*
gi 568925974 101 LSRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18293   82 VSSEEAQDVLAAARRLQISELESLC 106
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-125 9.04e-13

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 65.73  E-value: 9.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  38 DVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEE-VTARGFGPLLQFAYTAKLLLSRENIREVIR----C 112
Cdd:cd18295   21 DVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPlVNPDAFRALLQYLYTGRLEIHVDDVEDCKRlakqC 100

                         90
                 ....*....|...
gi 568925974 113 AEFLRMHNLEDSC 125
Cdd:cd18295  101 RLEELIEELEAKC 113
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-129 1.51e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 64.95  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  38 DVTLIVERKEFRAHRAVLAACSEYFWQALVG---QTKDDLVVSlpEEVTARGFGPLLQFAYTAKLLLSRENIREVIrcaE 114
Cdd:cd18287   24 DVTFVVEEKRFPAHRVILAARSEYFRALLYGgmrESQQSEIEL--KDTNAEAFKALLKYIYTGRLTLTDLKEDVLL---D 98

                         90       100
                 ....*....|....*....|.
gi 568925974 115 FLRMHN------LEDSCFSFL 129
Cdd:cd18287   99 VLGLAHqygfeeLEAAISDYL 119
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-118 1.58e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 64.82  E-value: 1.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  16 STVHCANILLGLNDQR-KKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDlVVSLpEEVTARGFGPLLQFA 94
Cdd:cd18226    1 SLQYNKNLLKYLNDDRqKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTD-AVTL-DHVSYSVFQHLLEFL 78

                         90       100
                 ....*....|....*....|....
gi 568925974  95 YTAKLLLSRENIREVIRCAEFLRM 118
Cdd:cd18226   79 YTSEFFVYENEIPLVLEAAKFLDI 102
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-138 2.30e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 64.87  E-value: 2.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  26 GLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVgqtkDDLVVSLPEEVTARGFGP-----LLQFAYTAKLL 100
Cdd:cd18236   14 GLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFC----NDLKEKYEEKIIIKGVDAetmqiLLDYTYTSKVL 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568925974 101 LSRENIREVIRCA---EFLRMhnlEDSCFSFLqTQLLNRED 138
Cdd:cd18236   90 ITKQNVQRVLEAAslfQFLRM---VDACASFL-TEALHPEN 126
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-127 2.39e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 64.47  E-value: 2.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  15 ESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVGQTKDDLVVSLPEE-VTARGFGPLLQF 93
Cdd:cd18224    5 HSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYF-QKLFLSTELDVARTYVVDfITPANFEKVLSF 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568925974  94 AYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFS 127
Cdd:cd18224   84 IYTSELFTDLINVGVIYEVAEKLGMEDLLKACHS 117
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 5.67e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 63.91  E-value: 5.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALvgqTKDDLVVslpEEVTARGFGPLLQFAYTAK 98
Cdd:cd18243   15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF---SINNLVL---QGCSSIGLRLVLEYLYTAN 88

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568925974  99 LLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18243   89 VTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQI 123
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-136 8.19e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 62.91  E-value: 8.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  14 YESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDdlvvSLPEEVTARGFG----- 88
Cdd:cd18251    1 YRSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLRE----MQQTEVLIHGVSynamc 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568925974  89 PLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNR 136
Cdd:cd18251   77 KILDFIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNE 124
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 1.40e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 61.98  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTARGFGPLLQFAYTAK 98
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAK 80

                         90       100
                 ....*....|....*....|....*..
gi 568925974  99 LLLSRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18204   81 ISVKKEDVNLMMSSGQILGIRFLDKLC 107
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-130 1.64e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 62.37  E-value: 1.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  22 NILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTArgFGPLLQFAYTAKLLL 101
Cdd:cd18222   11 SVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTV--FEQLLSFCYTGRICL 88

                         90       100
                 ....*....|....*....|....*....
gi 568925974 102 SRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:cd18222   89 QLADIISYLTAASFLQMQHIIDKCTQILE 117
bZIP_Maf pfam03131
bZIP Maf transcription factor; Maf transcription factors contain a conserved basic region ...
 616-691 2.08e-11

bZIP Maf transcription factor; Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.


Pssm-ID: 427158 [Multi-domain]  Cd Length: 92  Bit Score: 60.82  E-value: 2.08e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568925974  616 FPVDQITDLPRNDFQMMIKmhKLTSEQLEFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSER 691
Cdd:pfam03131   1 LSDEELLSMSVREFNRFLR--GLTEEEVIRLKQRRRRLKNRGYAQSCRKRRLQQKESLEKERSELREQLERLVQEL 74
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-133 2.87e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 61.73  E-value: 2.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  23 ILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDdlvvSLPEEVTARGFGP-----LLQFAYTA 97
Cdd:cd18268   10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRE----SSQAKVDLKGIDSdvldqIVDYVYTG 85

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568925974  98 KLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18268   86 EILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQL 121
bZIP cd14686
Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and ...
 649-696 3.21e-11

Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain; Basic leucine zipper (bZIP) factors comprise one of the most important classes of enhancer-type transcription factors. They act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes including cell survival, learning and memory, lipid metabolism, and cancer progression, among others. They also play important roles in responses to stimuli or stress signals such as cytokines, genotoxic agents, or physiological stresses. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269834 [Multi-domain]  Cd Length: 52  Bit Score: 59.10  E-value: 3.21e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 568925974 649 IRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKA 696
Cdd:cd14686    2 ERRRERNREAARRSRERKKERIEELEEEVEELEEENEELKAELEELRA 49
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-109 3.48e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 61.04  E-value: 3.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTARGFGPLLQFAYTAK 98
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQSVFQLDFCEPDAFENVLNYIYSSS 80

                         90
                 ....*....|.
gi 568925974  99 LLLSRENIREV 109
Cdd:cd18209   81 LFVEKSSLAAV 91
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 38-125 3.89e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 60.05  E-value: 3.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  38 DVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLP-EEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFL 116
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTlEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKY 87


                 ....*....
gi 568925974 117 RMHNLEDSC 125
Cdd:cd18314   88 QVPDLEKLC 96
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-125 7.22e-11

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 59.53  E-value: 7.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  38 DVTLIVERKE-FRAHRAVLAACSEYFWQALVGQTkddlVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFL 116
Cdd:cd18299   14 DVVFILQGGVrIFAHRIVLAAASSVFADLFLMMT----VVTLDSDITPEAFRRVLEFLYTGVLDENEDDLKELKDAAELL 89


                 ....*....
gi 568925974 117 RMHNLEDSC 125
Cdd:cd18299   90 ELFDLVMMC 98
bZIP_XBP1 cd14691
Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a ...
 648-702 1.06e-10

Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain; XBP1, a member of the Basic leucine zipper (bZIP) family, is the key transcription factor that orchestrates the unfolded protein response (UPR). It is the most conserved component of the UPR and is critical for cell fate determination in response to ER stress. The inositol-requiring enzyme 1 (IRE1)-XBP1 pathway is one of the three major sensors at the ER membrane that initiates the UPR upon activation. IRE1, a type I transmembrane protein kinase and endoribonuclease, oligomerizes upon ER stress leading to its increased activity. It splices the XBP1 mRNA, producing a variant that translocates to the nucleus and activates its target genes, which are involved in protein folding, degradation, and trafficking. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269839 [Multi-domain]  Cd Length: 58  Bit Score: 57.60  E-value: 1.06e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568925974 648 DIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELL 702
Cdd:cd14691    4 DLRRKLKNRVAAQTARDRKKARMDELEERVRELEEENQKLRAENESLRARNEDLL 58
bZIP_Jun cd14696
Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and ...
 650-695 1.10e-10

Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain; Jun is a member of the activator protein-1 (AP-1) complex, which is mainly composed of Basic leucine zipper (bZIP) dimers of the Jun and Fos families, and to a lesser extent, the activating transcription factor (ATF) and musculoaponeurotic fibrosarcoma (Maf) families. The broad combinatorial possibilities for various dimers determine binding specificity, affinity, and the spectrum of regulated genes. The AP-1 complex is implicated in many cell functions including proliferation, apoptosis, survival, migration, tumorigenesis, and morphogenesis, among others. There are three Jun proteins: c-Jun, JunB, and JunD. c-Jun is the most potent transcriptional activator of the AP-1 proteins. Both c-Jun and JunB are essential during development; deletion of either results in embryonic lethality in mice. c-Jun is essential in hepatogenesis and liver erythropoiesis, while JunB is required in vasculogenesis and angiogenesis in extraembryonic tissues. While JunD is dispensable in embryonic development, it is involved in transcription regulation of target genes that help cells to cope with environmental signals. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269844 [Multi-domain]  Cd Length: 61  Bit Score: 57.59  E-value: 1.10e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568925974 650 RRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLK 695
Cdd:cd14696    4 RKRARNRIAASKCRKRKLERIARLEDKVKELKNQNSELTSTASLLR 49
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 2.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 59.12  E-value: 2.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEevTARGFGPLLQFAYTAK 98
Cdd:cd18203    8 HEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLMH--SSRVVADLLLSCYTGA 85

                         90       100
                 ....*....|....*....|....*..
gi 568925974  99 LLLSRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18203   86 LEFSVRDIVNYLTAASYLQMEHVVEKC 112
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-129 2.28e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 58.51  E-value: 2.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLaACSEYFWQALVGQTKDDLVVSLpeeVTARGFGPLLQFAYTAK 98
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVL-ACTSKMFEILFHRNSQHYTLDF---LSPKTFQQILEYAYTAT 76

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568925974  99 LLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18205   77 LQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 2.42e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 58.90  E-value: 2.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwqalVGQTKDDLVVSLPEEVTARGFGP-----LLQF 93
Cdd:cd18336    2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYF----AAMFTNDVREAKQEEIKMEGVDPdalkaLVHY 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568925974  94 AYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18336   78 AYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQL 117
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-131 2.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 58.88  E-value: 2.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  23 ILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTArgFGPLLQFAYTAKLLLS 102
Cdd:cd18220   12 VLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNV--FEQLLSFCYTGRMSLQ 89

                         90       100
                 ....*....|....*....|....*....
gi 568925974 103 RENIREVIRCAEFLRMHNLEDSCFSFLQT 131
Cdd:cd18220   90 LKDVVSFLTAASFLQMQCVIDKCTQILES 118
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 27-118 2.48e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 58.37  E-value: 2.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  27 LNDQRKKDILCDVTL-IVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTARGFGPLLQFAYTAKLLLSREN 105
Cdd:cd18311    5 LQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMPNELQADAVVPVINFMYTGQLEFEEKS 84

                         90
                 ....*....|...
gi 568925974 106 IREVIRCAEFLRM 118
Cdd:cd18311   85 YGKLLRTAKELNM 97
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 3.42e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 58.15  E-value: 3.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  22 NILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDdlvVSLPEEVTARGFGPLLQFAYTAKLLL 101
Cdd:cd18208   11 SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD---IEIPSVVSVQSVQKLIDFMYSGVLRV 87

                         90       100
                 ....*....|....*....|....
gi 568925974 102 SRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18208   88 SQSEALQILTAASILQIKTVIDEC 111
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-133 4.14e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 58.68  E-value: 4.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  11 MYVYESTVHCANILLGLNDQRKKDILCDVTLIVERKE--------FRAHRAVLAACSEYFWQALVGqtkdDLVVSLPEEV 82
Cdd:cd18273    1 PEELEDAAHARALLAQLKSFYDARLLTDVTIEVNGPGsgpgsgrlFPCNRNVLAAASPYFKSMFTG----GLYESKQETV 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568925974  83 TARGFGP-----LLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18273   77 TIHDVDSesmalIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRL 132
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-128 8.37e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 56.35  E-value: 8.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  37 CDVTLIVERKEFRAHRAVLAACSEYFwQALVG----QTKDDLVVSL------PEEVTArgfgpLLQFAYTAKLLLSRENI 106
Cdd:cd18307    2 CDVVISVDNHSFAAHRNVLAAVSPFV-KSLISsndmKATDELSITIdcdylsPETVEQ-----LLDYFYTGKIVISEKNV 75

                         90       100
                 ....*....|....*....|..
gi 568925974 107 REVIRCAEFLRMHNLEDSCFSF 128
Cdd:cd18307   76 EDLLKGAKYFNIPRLKDHCVDF 97
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-136 9.36e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 56.79  E-value: 9.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  22 NILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFW-QALVGQTKddlvVSLPEEVTARGFGPLLQFAYTAKLL 100
Cdd:cd18229    4 SLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHdKLLLGHSE----IEVPPVVPAQTVRQLVEFMYSGSLV 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568925974 101 LSRENIREVIRCAEFLRMHNLEDSCfsflqTQLLNR 136
Cdd:cd18229   80 VAQSEALQILTAASILQIKTVIDEC-----TQIISQ 110
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-129 9.90e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 56.76  E-value: 9.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  23 ILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQ---TKDDLVVSlPEEvtargFGPLLQFAYTAKL 99
Cdd:cd18225   10 LLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTdtiSIDASVVS-PEE-----FALLLEMVYTGKL 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 568925974 100 LLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18225   84 PPGKHNFTKIISVADSLQMFDVAVSCKNLL 113
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 39-116 1.51e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 54.98  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  39 VTLIVERKEFRAHRAVLAACSEYFwQALV---GQTKDDLVVSLPeEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEF 115
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYF-RALFrggFRESGQAEINLR-DISPEDFRALLEFLYGGKRDLDASNLLELLEAANF 78


                 .
gi 568925974 116 L 116
Cdd:cd01165   79 L 79
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-129 1.52e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 56.76  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  16 STVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVG---QTKDDLVVSLpEEVTARGFGPLLQ 92
Cdd:cd18271    4 AECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFF-RAMFEvnmKERDDGSVTI-SNLSPKAVKAFLD 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568925974  93 FAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18271   82 YAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFL 118
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-129 1.71e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 56.10  E-value: 1.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  31 RKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLvvSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVI 110
Cdd:cd18218   13 RPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQW--CLGEGISPSTFKQLLDFVYGESVEVQPGELRPLL 90

                         90
                 ....*....|....*....
gi 568925974 111 RCAEFLRMHNLEDSCFSFL 129
Cdd:cd18218   91 EAARALEVESLEEACWRAL 109
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-133 4.81e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 55.05  E-value: 4.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  32 KKDILCDVTLIVERKEFRAHRAVLAACSEYFwqalVGQTKDDLVVSLPEEVTARGFGP-----LLQFAYTAKLLLSRENI 106
Cdd:cd18335   15 KQQQLCDVILIAGNRKIPAHRLVLSAVSDYF----AAMFTSDVCEAKQEEIKMEGIDPnalwdLVQFAYTGCLELKEDTI 90

                         90       100
                 ....*....|....*....|....*..
gi 568925974 107 REVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18335   91 ENLLAAACLLQLSQVVEVCCHFLMKLL 117
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-138 8.91e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 54.43  E-value: 8.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQ----ALVGQTKDDLVVslpEEVTARGFGPLLQFA 94
Cdd:cd18276    4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAmftcGLMECSQREVVL---HDITAESVSIILNYM 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568925974  95 YTAKLLLSRENIREVIRCAEFLRMHNLedscFSFLQTQLLNRED 138
Cdd:cd18276   81 YSSDLHLTNSNVQGVATAAFFLQMEDI----FSVCQKYMMDHMD 120
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-133 8.95e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 54.46  E-value: 8.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  26 GLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEY----FWQALVGQTKDDLVVslpEEVTARGFGPLLQFAYTAKLLL 101
Cdd:cd18340   17 GLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYframFLSDLEESKKREIVL---EDVDPDVMGKILHYIYTSEIEI 93

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568925974 102 SRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18340   94 TEQNVQDIFAAANMFQIPSIFTVCVSFLQKRL 125
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-133 9.31e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 54.05  E-value: 9.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  32 KKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKD--DLVVSLPeEVTARGFGPLLQFAYTAKLLLSRENIREV 109
Cdd:cd18263    9 EKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKEstQSVVQLP-TIPAKDLRLLISFAYSGILHLSWENLFEA 87

                         90       100
                 ....*....|....*....|....
gi 568925974 110 IRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18263   88 TCTALQLQISGALALCLDFLQREI 111
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 9.31e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 54.45  E-value: 9.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKE-FRAHRAVLAACSEYFWQALVGQTKD--DLVVSLPeEVTARGFGPLLQFAY 95
Cdd:cd18252    4 HPADFLDAFRTFYLDGLFTDITLQCASGQiFHCHKAALAACSSYFKVMFTADMKEksNNVIKLS-GIDHDILEALVNYVY 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568925974  96 TAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18252   83 TSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHL 120
bZIP_Fos_like cd14699
Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos)-like transcription factors: a ...
 649-696 1.03e-08

Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos)-like transcription factors: a DNA-binding and dimerization domain; This subfamily is composed of Fos proteins (c-Fos, FosB, Fos-related antigen 1 (Fra-1), and Fra-2), Activating Transcription Factor-3 (ATF-3), and similar proteins. Fos proteins are members of the activator protein-1 (AP-1) complex, which is mainly composed of bZIP dimers of the Jun and Fos families, and to a lesser extent, ATF and musculoaponeurotic fibrosarcoma (Maf) families. The broad combinatorial possibilities for various dimers determine binding specificity, affinity, and the spectrum of regulated genes. The AP-1 complex is implicated in many cell functions including proliferation, apoptosis, survival, migration, tumorigenesis, and morphogenesis, among others. ATF3 is induced by various stress signals such as cytokines, genotoxic agents, or physiological stresses. It is implicated in cancer and host defense against pathogens. It negatively regulates the transcription of pro-inflammatory cytokines and is critical in preventing acute inflammatory syndromes. ATF3 dimerizes with Jun and other ATF proteins; the heterodimers function either as activators or repressors depending on the promoter context. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269847 [Multi-domain]  Cd Length: 59  Bit Score: 52.26  E-value: 1.03e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568925974 649 IRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEK-------LLSERNHLKA 696
Cdd:cd14699    3 RKRRERNKVAAAKCRQRRRELMEELQAEVEQLEDENEKlqseianLRSEKEQLEE 57
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-128 1.41e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 53.44  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  36 LCDVTLIVERKEFRAHRAVLAACSEYF--------WQAlvgqtKDDLVVSLPEEV-TARGFGPLLQFAYTAKLLLSRENI 106
Cdd:cd18292   17 LSDIVLRVGGKVFHAHRLILAKSSDVFrvmlsndwWSE-----SKQSEIELVEDPeCAAVFEKFLRYLYTGQISVNLETA 91

                         90       100
                 ....*....|....*....|..
gi 568925974 107 REVIRCAEFLRMHNLEDSCFSF 128
Cdd:cd18292   92 LPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 2.29e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 53.53  E-value: 2.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  14 YESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFwqalVGQTKDDLVVSLPEEVTARGFGP---- 89
Cdd:cd18337    1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYF----AAMFTNDVREAKQEEIKMEGVEPnalw 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568925974  90 -LLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18337   77 aLVQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQL 121
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 31-116 5.34e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 51.44  E-value: 5.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  31 RKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDdlVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVI 110
Cdd:cd18262   13 REQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLGSNGP--LPPLSLEVTPVGWEAVLTFAYTGVLGRNPATVGDIL 90


                 ....*.
gi 568925974 111 RCAEFL 116
Cdd:cd18262   91 VAAEAL 96
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-98 6.40e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 52.20  E-value: 6.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  16 STVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSlPEEVTARGFGPLLQFAY 95
Cdd:cd18213    1 VSSHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSECIKIQ-PTDIQPDIFSYLLHIMY 79


                 ...
gi 568925974  96 TAK 98
Cdd:cd18213   80 TGK 82
bZIP_1 pfam00170
bZIP transcription factor; The Pfam entry includes the basic region and the leucine zipper ...
 649-695 8.48e-08

bZIP transcription factor; The Pfam entry includes the basic region and the leucine zipper region.


Pssm-ID: 395118 [Multi-domain]  Cd Length: 60  Bit Score: 49.69  E-value: 8.48e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568925974  649 IRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLK 695
Cdd:pfam00170   3 EKRKQSNREAARRSRQRKQAYIEELERRVKALEGENKTLRSELEELK 49
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 1.14e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 51.53  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVER-KEFRAHRAVLAACSEYFWQALVgqtkDDLVVSLPEEVTARGFGP-----LLQ 92
Cdd:cd18274    5 HACSILQQLKAMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFT----SGLTESTQKEVRIVGVEAesmhlVLD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568925974  93 FAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18274   81 YAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRL 121
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 33-122 1.36e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 50.72  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  33 KDILC--------DVTLIVERKEFRAHRAVLAACSEYFwQALVgqtKDDLVVSLPEEVTARGFGP-----LLQFAYTAKL 99
Cdd:cd18286    6 KDLLQlflngedsDITIKVDGKTFKAHRCILCARSSYF-AAML---SGSWAESNSSEITLTGVSHaavsfVLLFIYGGVL 81

                         90       100
                 ....*....|....*....|....
gi 568925974 100 -LLSRENIREVIRCAEflrMHNLE 122
Cdd:cd18286   82 dLPDDVNLGELLSLAD---MYGLD 102
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-129 2.61e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 50.39  E-value: 2.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  32 KKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVG------QTKDDLvvslpEEVTARGFGPLLQFAYTAKLLLSREN 105
Cdd:cd18270   22 EQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSglseskQTHVHL-----RNVDAATLQIIITYAYTGNLAINDST 96

                         90       100
                 ....*....|....*....|....
gi 568925974 106 IREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18270   97 VEQLYETACFLQVEDVLQRCREYL 120
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-133 3.35e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 50.10  E-value: 3.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  26 GLNDQRKKDILCDVTLIVERKEFRAHRAVLAACS----EYFWQALVGQTKDDLVVslpEEVTARGFGPLLQFAYTAKLLL 101
Cdd:cd18269   17 GLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSpyfrAMFLSDLEESKKKEVVL---EDVDPDVMGMILKYLYTSEIDL 93

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568925974 102 SRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18269   94 NDQNVQDIFALASRFQIPSIFTVCVSYLQKRL 125
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-99 4.01e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 49.22  E-value: 4.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  19 HCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKdDLVVSLPEEVTARGFGPLLQFAYTAK 98
Cdd:cd18193    4 HGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTS-ECVRLKPTDIQPDIFSYLLHLMYTGK 82


                 .
gi 568925974  99 L 99
Cdd:cd18193   83 M 83
bZIP_ATF2 cd14687
Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar ...
 650-695 4.97e-07

Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain; ATF-2 is a sequence-specific DNA-binding protein that belongs to the Basic leucine zipper (bZIP) family of transcription factors. In response to stress, it activates a variety of genes including cyclin A, cyclin D, and c-Jun. ATF-2 also plays a role in the DNA damage response that is independent of its transcriptional activity. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269835 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.97e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568925974 650 RRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLK 695
Cdd:cd14687    4 RFLERNRIAASKCRQRKKQWVQQLEEKVRKLESENKALKAEVDKLR 49
bZIP_GCN4 cd12193
Basic leucine zipper (bZIP) domain of General control protein GCN4: a DNA-binding and ...
 650-696 1.08e-06

Basic leucine zipper (bZIP) domain of General control protein GCN4: a DNA-binding and dimerization domain; GCN4 was identified in Saccharomyces cerevisiae from mutations in a deficiency in activation with the general amino acid control pathway. GCN4 encodes a trans-activator of amino acid biosynthetic genes containing 2 acidic activation domains and a C-terminal bZIP domain. In amino acid-deprived cells, GCN4 is up-regulated leading to transcriptional activation of genes encoding amino acid biosynthetic enzymes. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269833 [Multi-domain]  Cd Length: 54  Bit Score: 46.02  E-value: 1.08e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568925974 650 RRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKA 696
Cdd:cd12193    5 AKRARNTLAARRSRARKLEEMEELEKRVEELEAENEELKTRAEVLEA 51
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-117 1.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 47.63  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  34 DILCDVTLIV--ERKEFRAHRAVLAACSEYFW-----QALVGQTKDDLVVS-LPEEVtargFGPLLQFAYTAKLLLSREN 105
Cdd:cd18294   12 PEFSDVKFLVgpERQEIFAHKCILAARCEVFRamfltGPQKESTQSPLVLSdIEPEV----FRAVLEFIYTNCVTLSNHT 87

                         90
                 ....*....|...
gi 568925974 106 IREVIRCA-EFLR 117
Cdd:cd18294   88 VIEVLAAAvEYGL 100
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-129 1.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 48.35  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  12 YVYESTVHCANILLGLNDQRKKDIL-CDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKD--DLVVSLpEEVTARGFG 88
Cdd:cd18272    7 YTFTDRSHSSRVAQSIMDLCLEDGLfADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEarNRVIEL-KDVSESVFQ 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568925974  89 PLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFL 129
Cdd:cd18272   86 LLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFL 126
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-125 1.78e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 47.56  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  23 ILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFW-QALVGQTKDDLVVSLPEEVTARgfgPLLQFAYTAKLLL 101
Cdd:cd18197   12 VLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRdQFLLNQSKQVRITILQSAEVGR---KLLLSCYTGALEV 88

                         90       100
                 ....*....|....*....|....
gi 568925974 102 SRENIREVIRCAEFLRMHNLEDSC 125
Cdd:cd18197   89 KKKELLKYLTAASYLQMVHIVEKC 112
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-118 8.35e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 45.17  E-value: 8.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  38 DVTLIVERKEFRAHRAVLAACSEYFWQALvgqTKDDLVVslpEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFLR 117
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARL---SRDILKV---KGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQ 79


                 .
gi 568925974 118 M 118
Cdd:cd18275   80 M 80
bZIP_CREB1 cd14690
Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) ...
 650-696 8.73e-06

Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain; CREB1 is a Basic leucine zipper (bZIP) transcription factor that plays a role in propagating signals initiated by receptor activation through the induction of cAMP-responsive genes. Because it responds to many signal transduction pathways, CREB1 is implicated to function in many processes including learning, memory, circadian rhythm, immune response, and reproduction, among others. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269838 [Multi-domain]  Cd Length: 55  Bit Score: 43.77  E-value: 8.73e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568925974 650 RRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKA 696
Cdd:cd14690    4 LRLEKNREAARECRRKKKEYVKCLENRVAVLENENKELREELKILKE 50
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 37-123 1.24e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 44.65  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  37 CDVTLIVERKEFRAHRAVLAACSEYFWQALVGQT---KDDLVVSLpEEVTARGFGPLLQFAYTaklllSRENIREviRCA 113
Cdd:cd18285   16 TDVTFYVGSTLFKAHKAILLARVPEFFSHIIGKLsslEDQEPINI-ENLEASEFKTFLRQVYT-----SDKNIKM--LEE 87

                         90
                 ....*....|
gi 568925974 114 EFLRMHNLED 123
Cdd:cd18285   88 EILKGKVLDQ 97
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 27-108 1.41e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 44.59  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  27 LNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQ-------ALVGQTKDDLVVSlpEEVTARGFGPLLQFAYTAKL 99
Cdd:cd18301    9 LDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKlflssllTSEDAVGCDVVHI--EKVPPEIFEQLLQFIYTDTC 86

                         90
                 ....*....|
gi 568925974 100 -LLSRENIRE 108
Cdd:cd18301   87 dLLTDGYKPK 96
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-99 2.37e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 44.63  E-value: 2.37e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568925974  37 CDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKD----DLVVslpEEVTARGFGPLLQFAYTAKL 99
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREenegEIVI---EDVEPPVFKALLHFIYKDEL 78
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-133 3.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 44.45  E-value: 3.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  26 GLNDQRKKDILCDVTLIVERKEFRAHRAVLAACS----EYFWQALVGQTKDDLVVslpEEVTARGFGPLLQFAYTAKLLL 101
Cdd:cd18341   17 GLKELLDENKFVDCTLKAGDKSLPCHRLILAACSpyfrEYFLSEESEEKKKEVVL---DNVDPNIMDMILKYLYSAEIDL 93

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568925974 102 SRENIREVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18341   94 NDGNVQDIFALASRFQIPSVFTVCVTYLQKRL 125
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 31-126 4.98e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 43.09  E-value: 4.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  31 RKKDILCDVTLIVERKEFRAHRAVLAACSEYFwQALVGQTK--DDLVVSLPE-EVTARGFGPLLQFAYTAKLLLSRENIR 107
Cdd:cd18312    4 RDTGEPSDITVRVGNTTFHLHKFPLCSKSGYF-KRLASSSSesDPSEIELNDfPGGAEAFELVAKFCYGMPINLTATNVV 82

                         90       100
                 ....*....|....*....|...
gi 568925974 108 EViRCA-EFLRM---HNLEDSCF 126
Cdd:cd18312   83 GL-RCAaEYLEMtesGNLGNLID 104
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 36-125 5.73e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 43.24  E-value: 5.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  36 LCDVTLIVERKEFRAHRAVLAACSEYFWQALVG--QTKDDLVVSLPeEVTARGFGPLLQFAYTAKLLLSRENIREVIRCA 113
Cdd:cd18352   13 LSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGgyREKEARDIEIP-NIRWEVFELMMRFIYTGSVDITNDIAKDLLRAA 91

                         90
                 ....*....|..
gi 568925974 114 EFLRMHNLEDSC 125
Cdd:cd18352   92 DQYLLEGLKRLC 103
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-145 6.00e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 43.08  E-value: 6.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  20 CANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEyFWQALVGQTKDDLVVS-LPEEVtargFGPLLQFAYTAK 98
Cdd:cd18303    2 ISRLLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSE-KWSNENLASTNELDLSdISYEV----VLALLRWLYTDE 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568925974  99 LLLSRENirevIRCAEFLRMHNledscfSFLQTQLLNR-EDGL--FVCRK 145
Cdd:cd18303   77 LDLTLDD----EFLLELMKAAK------RFQLTDLVERcERALmsSVNVD 116
bZIP_2 pfam07716
Basic region leucine zipper;
650-690 8.28e-05

Basic region leucine zipper;


Pssm-ID: 462244 [Multi-domain]  Cd Length: 51  Bit Score: 40.66  E-value: 8.28e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568925974  650 RRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSE 690
Cdd:pfam07716   4 DRRRKNNEAAKRSREKKKQKEEELEERVKELERENAQLRQK 44
PHA02713 PHA02713
hypothetical protein; Provisional
 14-130 8.71e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 46.16  E-value: 8.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  14 YESTVHCANILLGLNDQRKKDILCDVTLIV-ERKEFRAHRAVLAACSEYFWQALvgqTKDDLVVSLPEEVTARGFGP--- 89
Cdd:PHA02713   3 IDDIKHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLF---TTPMIIRDLVTRVNLQMFDKdav 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568925974  90 --LLQFAYTAKllLSRENIREVIRCAEFLRMHNLEDSCFSFLQ 130
Cdd:PHA02713  80 knIVQYLYNRH--ISSMNVIDVLKCADYLLIDDLVTDCESYIK 120
bZIP_Fos cd14721
Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization ...
 650-687 1.34e-04

Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain; Fos proteins are members of the activator protein-1 (AP-1) complex, which is mainly composed of Basic leucine zipper (bZIP) dimers of the Jun and Fos families, and to a lesser extent, the activating transcription factor (ATF) and musculoaponeurotic fibrosarcoma (Maf) families. The broad combinatorial possibilities for various dimers determine binding specificity, affinity, and the spectrum of regulated genes. The AP-1 complex is implicated in many cell functions including proliferation, apoptosis, survival, migration, tumorigenesis, and morphogenesis, among others. There are four Fos proteins: c-Fos, FosB, Fos-related antigen 1 (Fra-1), and Fra-2. In addition, FosB also exists as smaller splice variants FosB2 and deltaFosB2. They all contain an N-terminal region and a bZIP domain. c-Fos and FosB also contain a C-terminal transactivation domain which is absent in Fra-1/2 and the smaller FosB variants. Fos proteins can only heterodimerize with Jun and other AP-1 proteins, but cannot homodimerize. Fos:Jun heterodimers are more stable and can bind DNA with more affinity that Jun:Jun homodimers. Fos proteins can enhance the trans-activating and transforming properties of Jun proteins. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269869 [Multi-domain]  Cd Length: 62  Bit Score: 40.42  E-value: 1.34e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568925974 650 RRRSKNRIAAQRCRKRKLDCI--------------QNLECEIRKLVCEKEKL 687
Cdd:cd14721    4 VRRERNKLAAAKCRQRRVDLTntlqaeteqledekSSLQNEIANLQKQKEQL 55
bZIP_YAP cd14688
Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a ...
 650-696 1.92e-04

Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain; This subfamily is composed predominantly of AP-1-like transcription factors including Saccharomyces cerevisiae YAPs, Schizosaccharomyces pombe PAP1, and similar proteins. Members of this subfamily belong to the Basic leucine zipper (bZIP) family of transcription factors. The YAP subfamily is composed of eight members (YAP1-8) which may all be involved in stress responses. YAP1 is the major oxidative stress regulator and is also involved in iron metabolism (like YAP5) and detoxification of arsenic (like YAP8). YAP2 is involved in cadmium stress responses while YAP4 and YAP6 play roles in osmotic stress. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269836 [Multi-domain]  Cd Length: 63  Bit Score: 40.01  E-value: 1.92e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568925974 650 RRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKA 696
Cdd:cd14688    5 RRRAQNREAQRAFRERKKERIKELEQRVAELEEELAELEEELQELRA 51
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-133 2.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 41.49  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  36 LCDVTLIVERKEFRAHRAVLAACSEYFwQALV------GQTKDDLVVSLPEEVtargFGPLLQFAYTAK---LLLSRENI 106
Cdd:cd18297   12 MSDVTFLVEGRPFYAHKIVLVTASDRF-KSMLssgsteAQTPVIEIPDIRYDI----FQLMMQYLYTGGvesLDVAQDDA 86

                         90       100
                 ....*....|....*....|....*..
gi 568925974 107 REVIRCAEFLRMHNLEDSCFSFLQTQL 133
Cdd:cd18297   87 LELLRAASFFQLDGLKRHCEILLSQQI 113
bZIP_ATF3 cd14722
Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar ...
 650-694 2.54e-04

Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain; ATF-3 is a Basic leucine zipper (bZIP) transcription factor that is induced by various stress signals such as cytokines, genetoxic agents, or physiological stresses. It is implicated in cancer and host defense against pathogens. It negatively regulates the transcription of pro-inflammatory cytokines and is critical in preventing acute inflammatory syndromes. Mice deficient with ATF3 display increased susceptibility to endotoxic shock induced death. ATF3 dimerizes with Jun and other ATF proteins; the heterodimers function either as activators or repressors depending on the promoter context. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269870  Cd Length: 62  Bit Score: 39.75  E-value: 2.54e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568925974 650 RRRSKNRIAAQRCRKRK---LDCIQN----LECEIRKLVCEKEKLLSERNHL 694
Cdd:cd14722    4 RRRERNKVAAAKCRNKKkerTDCLQKesekLETQNAELKRQIEELKNEKQHL 55
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 37-95 4.21e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 40.83  E-value: 4.21e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568925974  37 CDVTLIVERKEFRAHRAVLAACSEYFwQALVGQ--TKDDLV-VSLPEEVTAR-GFGPLLQFAY 95
Cdd:cd18309   21 CDITLLLDGHPIPAHKAILAARCSYF-EAMFRSfmPEDNTVnISIGEMVPSRqAFDSLLRYIY 82
bZIP_ATF4 cd14692
Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar ...
 650-701 5.89e-04

Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain; ATF-4 was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). It is a Basic leucine zipper (bZIP) transcription factor that has been reported to act as both an activator or repressor. It is a critical component in both the unfolded protein response (UPR) and amino acid response (AAR) pathways. Under certain stress conditions, ATF-4 transcription is increased; accumulation of ATF-4 induces the expression of genes involved in amino acid metabolism and transport, mitochondrial function, redox chemistry, and others that ensure protein synthesis and recovery from stress. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269840 [Multi-domain]  Cd Length: 63  Bit Score: 38.71  E-value: 5.89e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568925974 650 RRRSKNRIAAQRCRKRKldciqNLECEIRKlvcEKEKLLSERN-HLKACMGEL 701
Cdd:cd14692    5 RKREQNKNAATRYRQKK-----REEKEELL---SEEEELEDRNrELKDEVEEL 49
bZIP_plant_BZIP46 cd14707
Basic leucine zipper (bZIP) domain of uncharaterized Plant BZIP transcription factors: a ...
 650-687 7.45e-04

Basic leucine zipper (bZIP) domain of uncharaterized Plant BZIP transcription factors: a DNA-binding and dimerization domain; This subfamily is composed of uncharacterized plant bZIP transciption factors with similarity to Glycine max BZIP46, which may be a drought-responsive gene. Plant bZIPs are involved in developmental and physiological processes in response to stimuli/stresses such as light, hormones, and temperature changes. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269855 [Multi-domain]  Cd Length: 55  Bit Score: 38.06  E-value: 7.45e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 568925974 650 RRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKL 687
Cdd:cd14707    4 RRMIKNRESAARSRARKQAYTNELELEVAHLKEENARL 41
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-125 1.20e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 39.96  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  36 LCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTARGFGPLLQFAY---TAKLLLSRENIREVIRC 112
Cdd:cd18351   24 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISYVKYHIFQLVMQYLYcggTESLLIKNNEIMELLSA 103

                         90
                 ....*....|...
gi 568925974 113 AEFLRMHNLEDSC 125
Cdd:cd18351  104 AKFFQLEALQRHC 116
bZIP_BATF cd14701
Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain; ...
 650-695 1.98e-03

Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain; Basic leucine zipper (bZIP) transcription factor ATF-like (BATF or SFA2), BATF2 (or SARI) and BATF3 form heterodimers with Jun proteins. They function as inhibitors of AP-1-driven transcription. Unlike most bZIP transcription factors that contain additional domains, BATF and BATF3 contain only the the bZIP DNA-binding and dimerization domain. BATF2 contains an additional C-terminal domain of unknown function. BATF:Jun hetrodimers preferentially bind to TPA response elements (TREs) with the consensus sequence TGA(C/G)TCA, and can also bind to a TGACGTCA cyclic AMP response element (CRE). In addition to negative regulation, BATF proteins also show positive transcriptional activities in the development of classical dendritic cells and T helper cell subsets, and in antibody production. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269849 [Multi-domain]  Cd Length: 58  Bit Score: 37.07  E-value: 1.98e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568925974 650 RRRSKNRIAAQRCRKR---KLDCI----QNLECEIRKLVCEKEKLLSERNHLK 695
Cdd:cd14701    6 RRREKNRDAAQRSRQKqteKADKLheesESLERANAALRKEIKDLTEELKYLT 58
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-136 3.20e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 38.27  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  22 NILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPE--EVTARgfgpLLQFAYTAKL 99
Cdd:cd18214   11 SMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLNDSREVQISILQnsEVGRQ----LLLSCYTGVL 86

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568925974 100 LLSRENIREVIRCAEFLRMHNLEDSCfsflqTQLLNR 136
Cdd:cd18214   87 EFPEMELVNYLTAASFLQMSHIVERC-----TQALWK 118
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-62 3.50e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 38.11  E-value: 3.50e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 568925974  32 KKDILCDVTLI-VERKEFRAHRAVLAACSEYF 62
Cdd:cd18302    1 KHSDLYDVTIVsEDGKEFPCHKCVLVARLEYF 32
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-125 3.92e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 38.05  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  38 DVTLIVERKEFRAHRAVLAACSEYFwQAL---------VGQTKDDlVVSLPeEVTARGFGPLLQFAYTAKLLLSRENIRE 108
Cdd:cd18296   19 DVCFQVEGHRFPCHKAFFCGRSDYF-KALlrdhfaeseENNGSIP-VVTLH-DVSPEVFAIVLYYIYTDDTDLPPENAYD 95

                         90
                 ....*....|....*..
gi 568925974 109 VIRCAEFLRMHNLEDSC 125
Cdd:cd18296   96 VLYVADMYLLPGLKRLC 112
bZIP_CREBZF cd14706
Basic leucine zipper (bZIP) domain of CREBZF/Zhangfei transcription factor and similar ...
 651-690 4.04e-03

Basic leucine zipper (bZIP) domain of CREBZF/Zhangfei transcription factor and similar proteins: a DNA-binding and dimerization domain; CREBZF (also called Zhangfei, ZF, LAZip, or SMILE) is a neuronal bZIP transcription factor that is involved in the infection cycle of herpes simplex virus (HSV) and related cellular processes. It suppresses the ability of the HSV transactivator VP16 to initiate the viral replicative cycle. CREBZF has also been implicated in the regulation of the human nerve growth factor receptor trkA and the tumor suppressor p53. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269854 [Multi-domain]  Cd Length: 54  Bit Score: 36.08  E-value: 4.04e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568925974 651 RRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSE 690
Cdd:cd14706    4 VMSKNAIAARENRLKKKEYVENLEKSVDKLKSENKELKKA 43
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-116 4.44e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 37.02  E-value: 4.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568925974  39 VTLIVERKEFRAHRAVLAACSEYF---WQALVGQTKDDlVVSLpEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEF 115
Cdd:cd18320    4 VKVWVEEQLFTVDKALLVENSEYFralFRSGMRECTQD-EIRL-QGLSARGFRIMLRVLAGERPILNGEEILQAIECAAF 81


                 .
gi 568925974 116 L 116
Cdd:cd18320   82 L 82
bZIP_ATF6 cd14700
Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar ...
 651-695 6.12e-03

Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain; ATF-6 is a type I membrane-bound Basic leucine zipper (bZIP) transcription factor that binds to the consensus ER stress response element (ERSE) and enhances the transcription of genes encoding glucose-regulated proteins Grp78, Grp94, and calreticulum. ATF-6 is one of three sensors of the unfolded protein response (UPR) in metazoans; the others being the kinases Ire1 and PERK. It contains an ER-lumenal domain that detects unfolded proteins. In response to ER stress, ATF-6 translocates from the ER to the Golgi with simultaneous cleavage in a process called regulated intramembrane proteolysis (Rip) to its transcriptionally competent form, which enters the nucleus and upregulates target UPR genes. The three UPR sensor branches cross-communicate to form a signaling network. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269848 [Multi-domain]  Cd Length: 52  Bit Score: 35.72  E-value: 6.12e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568925974 651 RRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLK 695
Cdd:cd14700    4 RMIKNRESACLSRKKKKEYVQSLETKLEQLKQENQKLKSENETLR 48
bZIP_HY5-like cd14704
Basic leucine zipper (bZIP) domain of Plant Elongated/Long Hypocotyl5 (HY5)-like transcription ...
 650-711 7.05e-03

Basic leucine zipper (bZIP) domain of Plant Elongated/Long Hypocotyl5 (HY5)-like transcription factors and similar proteins: a DNA-binding and dimerization domain; This subfamily is predominantly composed of plant Basic leucine zipper (bZIP) transcription factors with similarity to Solanum lycopersicum and Arabidopsis thaliana HY5. Also included are the Dictyostelium discoideum bZIP transcription factors E and F. HY5 plays an important role in seedling development and is a positive regulator of photomorphogenesis. Plants with decreased levels of HY5 show defects in light responses including inhibited photomorphogenesis, loss of alkaloid organization, and reduced carotenoid accumulation. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269852 [Multi-domain]  Cd Length: 52  Bit Score: 35.24  E-value: 7.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568925974 650 RRRSKNRIAAQRCRKRKLDCIQNLEceirklvcEKEKLLSERNhlkacmGELLDNFSCLSQE 711
Cdd:cd14704    3 RRLLRNRESAQLSRQRKKEYLSELE--------AKCRELEAEN------AELEARVELLQAE 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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