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Conserved domains on  [gi|568926115|ref|XP_006537700|]
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inversin isoform X12 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-234 4.98e-53

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.16  E-value: 4.98e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   1 MWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVI 80
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  81 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 160
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926115 161 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 234
Cdd:COG0666  217 NDGKTALDLAAENGNLEIVKLLLEAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 287-560 2.14e-10

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 64.42  E-value: 2.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  287 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 366
Cdd:PHA03307  176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  367 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 445
Cdd:PHA03307  254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  446 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 511
Cdd:PHA03307  329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926115  512 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 560
Cdd:PHA03307  407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 581-606 8.09e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.22  E-value: 8.09e-05
                         10        20
                 ....*....|....*....|....*.
gi 568926115 581 RKELFRRKNKAAAVIQRAWRSYQLRK 606
Cdd:cd23767    1 EEEELQRMNRAATLIQALWRGYKVRK 26
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 227-253 9.55e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 37.14  E-value: 9.55e-04
                         10        20
                 ....*....|....*....|....*..
gi 568926115 227 AIQDIAAFKIQAVYKGYKVRKAFRDRK 253
Cdd:cd23767    6 QRMNRAATLIQALWRGYKVRKELKKKK 32
C11orf65 super family cl41231
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ...
 588-634 5.08e-03

chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.


The actual alignment was detected with superfamily member cd21090:

Pssm-ID: 411042  Cd Length: 260  Bit Score: 39.23  E-value: 5.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568926115 588 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 634
Cdd:cd21090    4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-234 4.98e-53

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.16  E-value: 4.98e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   1 MWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVI 80
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  81 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 160
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926115 161 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 234
Cdd:COG0666  217 NDGKTALDLAAENGNLEIVKLLLEAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 10-228 3.32e-23

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 102.82  E-value: 3.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  10 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 82
Cdd:PHA03100  49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  83 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 160
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926115 161 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 228
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
Ank_2 pfam12796
Ankyrin repeats (3 copies);
68-160 2.34e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 91.72  E-value: 2.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   68 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 147
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 568926115  148 VLMENNADPNIQD 160
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 287-560 2.14e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 64.42  E-value: 2.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  287 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 366
Cdd:PHA03307  176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  367 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 445
Cdd:PHA03307  254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  446 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 511
Cdd:PHA03307  329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926115  512 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 560
Cdd:PHA03307  407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 24-171 4.61e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 4.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  24 INM---SDKYGG-TALHAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLI 84
Cdd:cd22192   78 VNEpmtSDLYQGeTALHIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLI 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  85 KGGArvDLVDQD--GHSLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMEN 152
Cdd:cd22192  157 EHGA--DIRAQDslGNTVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK 234

                        170
                 ....*....|....*....
gi 568926115 153 nadpniqdkegRTALHWSC 171
Cdd:cd22192  235 -----------RRHIQWTY 242
NESP55 pfam06390
Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian ...
 262-490 6.94e-05

Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, heat-stable secretory protein that is expressed exclusively in endocrine and nervous tissues, although less widely than chromogranins.


Pssm-ID: 115071 [Multi-domain]  Cd Length: 261  Bit Score: 45.24  E-value: 6.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  262 LRKDAAAKKREEEnkrKEAEQQKGQLDTDPPRSHCSSSAPVLPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPP 341
Cdd:pfam06390  42 LRALASSNARAQQ---RAAAQRRSFLNAHHRSAAAAAAAQVFPEPSEPESDHEDEDFEPELARPECLEYDEDDFDTETDS 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  342 GRCPGRASQGDSSIDLQG-----TASRKPSETPIEHCRGPsacVHPRSwEGGNSSKNQGTSSVEKRRGETNGKhrrceEG 416
Cdd:pfam06390 119 ETEPESDIESETEFETEPetepdTAPTTEPETEPEDEPGP---VVPKG-ATFHQSLTERLHALKLQSADASPR-----RA 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568926115  417 PSSARQPLCTGSGRPAEKGE-DSSPAvaSASQQDHPRKPNKRQDRAARPRGASQKRRThqlrdrcSPAGSSRPGS 490
Cdd:pfam06390 190 PPSTQEPESAREGEEPERGPlDKDPR--DPEEEEEEKEEEKQQPHRCKPKKPARRRDP-------SPESPPKKGA 255
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 581-606 8.09e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.22  E-value: 8.09e-05
                         10        20
                 ....*....|....*....|....*.
gi 568926115 581 RKELFRRKNKAAAVIQRAWRSYQLRK 606
Cdd:cd23767    1 EEEELQRMNRAATLIQALWRGYKVRK 26
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 96-125 2.49e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 2.49e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568926115    96 DGHSLLHWAALGGNADVCQILIENKINPNV 125
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 227-253 9.55e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 37.14  E-value: 9.55e-04
                         10        20
                 ....*....|....*....|....*..
gi 568926115 227 AIQDIAAFKIQAVYKGYKVRKAFRDRK 253
Cdd:cd23767    6 QRMNRAATLIQALWRGYKVRKELKKKK 32
C11orf65 cd21090
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ...
 588-634 5.08e-03

chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.


Pssm-ID: 411042  Cd Length: 260  Bit Score: 39.23  E-value: 5.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568926115 588 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 634
Cdd:cd21090    4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-234 4.98e-53

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.16  E-value: 4.98e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   1 MWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVI 80
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  81 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 160
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926115 161 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 234
Cdd:COG0666  217 NDGKTALDLAAENGNLEIVKLLLEAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-268 2.73e-51

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 180.54  E-value: 2.73e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   8 NDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGG 87
Cdd:COG0666   31 LLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  88 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 167
Cdd:COG0666  111 ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 168 HWSCNNGYLDAIKLLLDFAAFPNQMenNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRK 247
Cdd:COG0666  191 HLAAENGHLEIVKLLLEAGADVNAK--DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268

                        250       260
                 ....*....|....*....|.
gi 568926115 248 AFRDRKNLLMKHEQLRKDAAA 268
Cdd:COG0666  269 KLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-288 6.55e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 160.12  E-value: 6.55e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  16 LSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 95
Cdd:COG0666    6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  96 DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGY 175
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 176 LDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQFMLEHGA------------LSIAAIQDIAAFKIQAVYKGY 243
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGE--TPLHLAAENGHLEIVKLLLEAGAdvnakdndgktaLDLAAENGNLEIVKLLLEAGA 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568926115 244 KVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGQLD 288
Cdd:COG0666  244 DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-222 3.77e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.97  E-value: 3.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  47 VKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQ 126
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 127 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMenNEERYTPLDYAL 206
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQ--DNDGNTPLHLAA 161

                        170
                 ....*....|....*.
gi 568926115 207 LGERHEVIQFMLEHGA 222
Cdd:COG0666  162 ANGNLEIVKLLLEAGA 177
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 10-228 3.32e-23

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 102.82  E-value: 3.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  10 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 82
Cdd:PHA03100  49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  83 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 160
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926115 161 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 228
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
Ank_2 pfam12796
Ankyrin repeats (3 copies);
68-160 2.34e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 91.72  E-value: 2.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   68 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 147
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 568926115  148 VLMENNADPNIQD 160
Cdd:pfam12796  79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
101-192 3.08e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 91.33  E-value: 3.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  101 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEnNADPNIQDkEGRTALHWSCNNGYLDAIK 180
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 568926115  181 LLLDFAAFPNQM 192
Cdd:pfam12796  79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
35-127 2.37e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 89.02  E-value: 2.37e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   35 LHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKgGARVDLVDqDGHSLLHWAALGGNADVCQ 114
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 568926115  115 ILIENKINPNVQD 127
Cdd:pfam12796  79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
134-222 1.34e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.01  E-value: 1.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  134 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFpnqmENNEERYTPLDYALLGERHEV 213
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLEI 76


                  ....*....
gi 568926115  214 IQFMLEHGA 222
Cdd:pfam12796  77 VKLLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1-94 2.04e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.24  E-value: 2.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115    1 MWAAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNdAQVDATDvMKHTPLFRACEMGHRDVI 80
Cdd:pfam12796   2 HLAAKNGNLELVKLLL--ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 568926115   81 QTLIKGGARVDLVD 94
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 8-240 2.28e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 86.27  E-value: 2.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   8 NDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVST-VKLLLDNDAQVDATDVMKHTPLFRACEMGH-RDVIQTLIK 85
Cdd:PHA02876 250 NEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIM 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  86 GGARVDLVDQDGHSLLHWAA-LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 164
Cdd:PHA02876 330 LGADVNAADRLYITPLHQAStLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIG 409

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926115 165 TALHWS-CNNGYLDAIKLLLDFAAfpNQMENNEERYTPLDYALLGE-RHEVIQFMLEHGAlsiaaiqDIAAFKIQAVY 240
Cdd:PHA02876 410 TALHFAlCGTNPYMSVKTLIDRGA--NVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGA-------DVNAINIQNQY 478
PHA03095 PHA03095
ankyrin-like protein; Provisional
 10-169 2.38e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 82.38  E-value: 2.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  10 DVLRTMLSLKSDIdiNMSDKYGGTALHAAaLSG---HVSTVKLLLDNDAQVDATDVMKHTPL-----FRACEMghrDVIQ 81
Cdd:PHA03095  98 DVIKLLIKAGADV--NAKDKVGRTPLHVY-LSGfniNPKVIRLLLRKGADVNALDLYGMTPLavllkSRNANV---ELLR 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  82 TLIKGGARVDLVDQDGHSLLHWAALG--GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGyiNCMAVLM----ENNAD 155
Cdd:PHA03095 172 LLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLGNTPLHSMATGS--SCKRSLVlpllIAGIS 249

                        170
                 ....*....|....
gi 568926115 156 PNIQDKEGRTALHW 169
Cdd:PHA03095 250 INARNRYGQTPLHY 263
PHA03095 PHA03095
ankyrin-like protein; Provisional
 18-222 2.14e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 79.30  E-value: 2.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  18 LKSDIDINMSDKYGGTALHAAALSGH---VSTVKLLLDNDAQVDATDVMKHTPLFraCEMGH---RDVIQTLIKGGARVD 91
Cdd:PHA03095  34 LAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLH--LYLYNattLDVIKLLIKAGADVN 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  92 LVDQDGHSLLHwAALGG---NADVCQILIENKINPNVQDYAGRTPLqcAAYGGYINC----MAVLMENNADPNIQDKEGR 164
Cdd:PHA03095 112 AKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDAGADVYAVDDRFR 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 165 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE--RHEVIQFMLEHGA 222
Cdd:PHA03095 189 SLLHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGI 248
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 8-206 8.94e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 77.31  E-value: 8.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   8 NDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGG 87
Cdd:PHA02874 103 EKDMIKTIL--DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  88 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYggYINCMAVLMENNADPNIQDKEGRTAL 167
Cdd:PHA02874 181 AYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPL 258

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 568926115 168 HWSCNNG-YLDAIKLLLDFAAFPNQMENNEEryTPLDYAL 206
Cdd:PHA02874 259 HHAINPPcDIDIIDILLYHKADISIKDNKGE--NPIDTAF 296
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 24-231 1.32e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.54  E-value: 1.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  24 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMG-----------------------HRDVI 80
Cdd:PHA02874  28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiikllidngvdtsilpipciEKDMI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  81 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 160
Cdd:PHA02874 108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926115 161 KEGRTALHWSCNNGYLDAIKLLLDFAAfpNQMENNEERYTPLDYALLGERhEVIQFMLEHGALSiaaIQDI 231
Cdd:PHA02874 188 NNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNR-SAIELLINNASIN---DQDI 252
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 44-222 2.08e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 75.86  E-value: 2.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  44 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAA-----LGGNADVCQILIE 118
Cdd:PHA03100  15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 119 NKINPNVQDYAGRTPLQCAAYG--GYINCMAVLMENNADPNIQDKEGRTALHW--SCNNGYLDAIKLLLDFAAFPNQMEN 194
Cdd:PHA03100  95 YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLylESNKIDLKILKLLIDKGVDINAKNR 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 568926115 195 --------------NEERYTPLDYALLGERHEVIQFMLEHGA 222
Cdd:PHA03100 175 vnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGA 216
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 35-203 2.40e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.80  E-value: 2.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  35 LHAAALSGHVSTVKLLLDNDAQVDatDVM---KHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 111
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFAD--DVFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 112 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALHWSCNNGYLDAIKLLLDFAAFPN 190
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCN 229

                        170
                 ....*....|....
gi 568926115 191 QMENNE-ERYTPLD 203
Cdd:PHA02875 230 IMFMIEgEECTILD 243
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 2-167 2.03e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 73.07  E-value: 2.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   2 WAAGKGNDDVLRTMLSLKSDIdiNMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQ 81
Cdd:PHA02874 130 YAIKKGDLESIKMLFEYGADV--NIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  82 TLIKGGARVDLVDQDGHSLLHWAALgGNADVCQILIENKiNPNVQDYAGRTPLQCA-AYGGYINCMAVLMENNADPNIQD 160
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIELLINNA-SINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKD 285


                 ....*..
gi 568926115 161 KEGRTAL 167
Cdd:PHA02874 286 NKGENPI 292
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 47-207 9.02e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 71.06  E-value: 9.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  47 VKLLLDNDAQVDATDVMK-HTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNV 125
Cdd:PHA02878 150 TKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 126 QDYAGRTPLQCAAygGY---INCMAVLMENNADPNIQDK-EGRTALHWSCNNGylDAIKLLLDFAAFPNQMenNEERYTP 201
Cdd:PHA02878 230 RDKCGNTPLHISV--GYckdYDILKLLLEHGVDVNAKSYiLGLTALHSSIKSE--RKLKLLLEYGADINSL--NSYKLTP 303


                 ....*.
gi 568926115 202 LDYALL 207
Cdd:PHA02878 304 LSSAVK 309
PHA03095 PHA03095
ankyrin-like protein; Provisional
 8-183 4.29e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.90  E-value: 4.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   8 NDDVLRTMLSLKsdIDINMSDKYGGTALHAAALSGHVS--TVKLLLDNDAQVDATDVMKHTPL------FRACEmghrDV 79
Cdd:PHA03095 131 NPKVIRLLLRKG--ADVNALDLYGMTPLAVLLKSRNANveLLRLLIDAGADVYAVDDRFRSLLhhhlqsFKPRA----RI 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  80 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI--LIENKINPNVQDYAGRTPLQCAAYggYINCMAV--LMENNAD 155
Cdd:PHA03095 205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAV--FNNPRACrrLIALGAD 282

                        170       180
                 ....*....|....*....|....*...
gi 568926115 156 PNIQDKEGRTALHWSCNNGYLDAIKLLL 183
Cdd:PHA03095 283 INAVSSDGNTPLSLMVRNNNGRAVRAAL 310
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 12-222 8.71e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 68.55  E-value: 8.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  12 LRTMLSLKSDIdiNMSDKYGGTALH-AAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARV 90
Cdd:PHA02876 324 IRTLIMLGADV--NAADRLYITPLHqASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  91 DLVDQDGHSLLHWAALGGNAdvcqilienkinpnvqdyagrtplqcaayggYINcMAVLMENNADPNIQDKEGRTALHWS 170
Cdd:PHA02876 402 EALSQKIGTALHFALCGTNP-------------------------------YMS-VKTLIDRGANVNSKNKDLSTPLHYA 449

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568926115 171 C-NNGYLDAIKLLLDFAAFPNQMeNNEERYtPLDYALlgERHEVIQFMLEHGA 222
Cdd:PHA02876 450 CkKNCKLDVIEMLLDNGADVNAI-NIQNQY-PLLIAL--EYHGIVNILLHYGA 498
Ank_4 pfam13637
Ankyrin repeats (many copies);
97-149 1.08e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 57.28  E-value: 1.08e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568926115   97 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 149
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 29-172 1.14e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.24  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  29 KYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 108
Cdd:PHA02875 100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926115 109 NADVCQILIENKINPNvqdYAGRTP---LQCAAY-GGYINCMAVLMENNADPNIQ---DKEGRTALHWSCN 172
Cdd:PHA02875 180 DIAICKMLLDSGANID---YFGKNGcvaALCYAIeNNKIDIVRLFIKRGADCNIMfmiEGEECTILDMICN 247
PHA02798 PHA02798
ankyrin-like protein; Provisional
 44-203 1.14e-10

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 64.47  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  44 VSTVKLLLdndAQVDATDVMKHTPLFRacEMGHR-----DVIQTLIKGGARVDLVDQDGHS-----LLHWAALGGNADVC 113
Cdd:PHA02798  18 LSTVKLLI---KSCNPNEIVNEYSIFQ--KYLQRdspstDIVKLFINLGANVNGLDNEYSTplctiLSNIKDYKHMLDIV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 114 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL---MENNADPNIQDKEGRTALH---WSCNNGYLDAIKLLLDFAA 187
Cdd:PHA02798  93 KILIENGADINKKNSDGETPLYCLLSNGYINNLEILlfmIENGADTTLLDKDGFTMLQvylQSNHHIDIEIIKLLLEKGV 172

                        170
                 ....*....|....*.
gi 568926115 188 FPNQMeNNEERYTPLD 203
Cdd:PHA02798 173 DINTH-NNKEKYDTLH 187
Ank_4 pfam13637
Ankyrin repeats (many copies);
31-84 1.50e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.90  E-value: 1.50e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568926115   31 GGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLI 84
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 287-560 2.14e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 64.42  E-value: 2.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  287 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 366
Cdd:PHA03307  176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  367 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 445
Cdd:PHA03307  254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  446 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 511
Cdd:PHA03307  329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926115  512 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 560
Cdd:PHA03307  407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 8-125 2.43e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.09  E-value: 2.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   8 NDDVLRTMLSLKSDIDINMSDKYggTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGG 87
Cdd:PHA02875 114 KLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568926115  88 ARVDLVDQDGH-SLLHWAALGGNADVCQILIENKINPNV 125
Cdd:PHA02875 192 ANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCNI 230
Ank_4 pfam13637
Ankyrin repeats (many copies);
130-183 3.43e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.13  E-value: 3.43e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568926115  130 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 183
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 6-167 3.78e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 62.98  E-value: 3.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   6 KGNDDVLRTM---LSLKSDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQ 81
Cdd:PHA02878 139 KSKDDIIEAEitkLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVH 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  82 TLIKGGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKINPNVQDYA-GRTPLQCAAYGGYIncMAVLMENNADPNIQ 159
Cdd:PHA02878 219 ILLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYIlGLTALHSSIKSERK--LKLLLEYGADINSL 296


                 ....*...
gi 568926115 160 DKEGRTAL 167
Cdd:PHA02878 297 NSYKLTPL 304
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 3-155 9.35e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 62.19  E-value: 9.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   3 AAGKGNDDVLRTMLSLKSDIDInmSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQT 82
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDI--GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRI 609

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926115  83 LIKGGARVDlvDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 155
Cdd:PLN03192 610 LYHFASISD--PHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
Ank_4 pfam13637
Ankyrin repeats (many copies);
2-51 1.55e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.20  E-value: 1.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568926115    2 WAAGKGNDDVLRTMLSLKsdIDINMSDKYGGTALHAAALSGHVSTVKLLL 51
Cdd:pfam13637   7 AAAASGHLELLRLLLEKG--ADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 9-232 3.18e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.46  E-value: 3.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   9 DDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGA 88
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  89 RV---DL--------VDQDGHSLLHWAALGGNA-DVCQ------------------ILIENKINPNVQDYAGRTPLQCAA 138
Cdd:PHA02876 236 NInknDLsllkairnEDLETSLLLYDAGFSVNSiDDCKntplhhasqapslsrlvpKLLERGADVNAKNIKGETPLYLMA 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 139 YGGY-INCMAVLMENNADPNIQDKEGRTALHWSCN-NGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQF 216
Cdd:PHA02876 316 KNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDK--TPIHYAAVRNNVVIINT 393

                        250
                 ....*....|....*.
gi 568926115 217 MLEHGALSIAAIQDIA 232
Cdd:PHA02876 394 LLDYGADIEALSQKIG 409
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 100-183 3.89e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.91  E-value: 3.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 100 LLHWAAlGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAI 179
Cdd:PTZ00322  86 LCQLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164


                 ....
gi 568926115 180 KLLL 183
Cdd:PTZ00322 165 QLLS 168
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 34-222 4.38e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.23  E-value: 4.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  34 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA-DV 112
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVkAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 113 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqM 192
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD-I 163

                        170       180       190
                 ....*....|....*....|....*....|
gi 568926115 193 ENNEErYTPLDYALLGERHEVIQFMLEHGA 222
Cdd:PHA02875 164 EDCCG-CTPLIIAMAKGDIAICKMLLDSGA 192
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 148-220 4.79e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.53  E-value: 4.79e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926115 148 VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQFMLEH 220
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK--TPLELAEENGFREVVQLLSRH 170
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 18-95 3.22e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.60  E-value: 3.22e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926115  18 LKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 95
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
Ank_4 pfam13637
Ankyrin repeats (many copies);
66-117 3.92e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 3.92e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568926115   66 TPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 117
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 104-190 5.36e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.41  E-value: 5.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 104 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 183
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611


                 ....*..
gi 568926115 184 DFAAFPN 190
Cdd:PLN03192 612 HFASISD 618
Ank_5 pfam13857
Ankyrin repeats (many copies);
116-168 1.86e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.11  E-value: 1.86e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568926115  116 LIENK-INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 168
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
153-205 6.67e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 6.67e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568926115  153 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYA 205
Cdd:pfam13857   6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN--LKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
86-137 1.04e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.19  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568926115   86 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 137
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
163-218 1.27e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 1.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568926115  163 GRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYALLGERHEVIQFML 218
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADIN--AVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 39-116 1.46e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.82  E-value: 1.46e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926115  39 ALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQIL 116
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 18-85 2.07e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.05  E-value: 2.07e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926115  18 LKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 85
Cdd:PTZ00322 102 LTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 37-183 2.74e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.02  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  37 AAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQIL 116
Cdd:PLN03192 531 TVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926115 117 IE--NKINPnvqdYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 183
Cdd:PLN03192 611 YHfaSISDP----HAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 24-171 4.61e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 4.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  24 INM---SDKYGG-TALHAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLI 84
Cdd:cd22192   78 VNEpmtSDLYQGeTALHIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLI 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  85 KGGArvDLVDQD--GHSLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMEN 152
Cdd:cd22192  157 EHGA--DIRAQDslGNTVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK 234

                        170
                 ....*....|....*....
gi 568926115 153 nadpniqdkegRTALHWSC 171
Cdd:cd22192  235 -----------RRHIQWTY 242
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 3-151 1.62e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.33  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   3 AAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDAT---DVMKHTPLFRAC---EMGH 76
Cdd:PLN03192 629 AAKRNDLTAMKELL--KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAntdDDFSPTELRELLqkrELGH 706

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926115  77 RDVIqtlikggarVDLVDQDgHSLLHWAALGGNADVCQILIENKINPNVQDYAG----RTPLQCAAYGGYINCMAVLME 151
Cdd:PLN03192 707 SITI---------VDSVPAD-EPDLGRDGGSRPGRLQGTSSDNQCRPRVSIYKGhpllRNERCCNEAGKLINLPPSLEE 775
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 3-134 1.81e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115   3 AAGKGNDDVLRTMLsLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDND---AQVDATDVM--KHTPLFRACEMGHR 77
Cdd:cd22192   24 AAKENDVQAIKKLL-KCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDLyqGETALHIAVVNQNL 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926115  78 DVIQTLIKGGARVDLVDQDG-------HSLLHW-------AALGGNADVCQILIENKINPNVQDYAGRTPL 134
Cdd:cd22192  103 NLVRELIARGADVVSPRATGtffrpgpKNLIYYgehplsfAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 80-150 3.53e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 3.53e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926115  80 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM 150
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 30-61 4.01e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 4.01e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568926115   30 YGGTALHAAALS-GHVSTVKLLLDNDAQVDATD 61
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 63-222 5.10e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.52  E-value: 5.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  63 MKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 142
Cdd:PHA02875   1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 143 INCMAVLMENNADPN-IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQmeNNEERYTPLDYALLGERHEVIQFMLEHG 221
Cdd:PHA02875  81 VKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI--PNTDKFSPLHLAVMMGDIKGIELLIDHK 158


                 .
gi 568926115 222 A 222
Cdd:PHA02875 159 A 159
NESP55 pfam06390
Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian ...
 262-490 6.94e-05

Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, heat-stable secretory protein that is expressed exclusively in endocrine and nervous tissues, although less widely than chromogranins.


Pssm-ID: 115071 [Multi-domain]  Cd Length: 261  Bit Score: 45.24  E-value: 6.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  262 LRKDAAAKKREEEnkrKEAEQQKGQLDTDPPRSHCSSSAPVLPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPP 341
Cdd:pfam06390  42 LRALASSNARAQQ---RAAAQRRSFLNAHHRSAAAAAAAQVFPEPSEPESDHEDEDFEPELARPECLEYDEDDFDTETDS 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  342 GRCPGRASQGDSSIDLQG-----TASRKPSETPIEHCRGPsacVHPRSwEGGNSSKNQGTSSVEKRRGETNGKhrrceEG 416
Cdd:pfam06390 119 ETEPESDIESETEFETEPetepdTAPTTEPETEPEDEPGP---VVPKG-ATFHQSLTERLHALKLQSADASPR-----RA 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568926115  417 PSSARQPLCTGSGRPAEKGE-DSSPAvaSASQQDHPRKPNKRQDRAARPRGASQKRRThqlrdrcSPAGSSRPGS 490
Cdd:pfam06390 190 PPSTQEPESAREGEEPERGPlDKDPR--DPEEEEEEKEEEKQQPHRCKPKKPARRRDP-------SPESPPKKGA 255
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 581-606 8.09e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.22  E-value: 8.09e-05
                         10        20
                 ....*....|....*....|....*.
gi 568926115 581 RKELFRRKNKAAAVIQRAWRSYQLRK 606
Cdd:cd23767    1 EEEELQRMNRAATLIQALWRGYKVRK 26
Ank_5 pfam13857
Ankyrin repeats (many copies);
21-68 9.69e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 9.69e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568926115   21 DIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPL 68
Cdd:pfam13857   6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA03378 PHA03378
EBNA-3B; Provisional
 286-550 1.21e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 286 QLDTDPPRSHCSSSAPVLPCPPSPQNEASKQDATPSKQppaSHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKP 365
Cdd:PHA03378 575 QPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQ---SHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTP 651

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 366 SETP-IEHCRGPSACVHPRSWEGGNSSKNQGTSsveKRRGETNGKHR---------RCEEGPSSARQPLCTGSGRPAEKG 435
Cdd:PHA03378 652 HQPPqVEITPYKPTWTQIGHIPYQPSPTGANTM---LPIQWAPGTMQpppraptpmRPPAAPPGRAQRPAAATGRARPPA 728

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 436 EDSSPAVASASQQDHPRKPNKRQDRAARPRGASQKRR-------------------THQLRDRCSPAGSSRPGSAKGEVA 496
Cdd:PHA03378 729 AAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARppaaapgaptpqpppqappAPQQRPRGAPTPQPPPQAGPTSMQ 808

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568926115 497 CADQSSLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRsGCKQLYEDICASPETG 550
Cdd:PHA03378 809 LMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAA-LERQAAAGPTPSPGSG 861
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 96-125 2.49e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 2.49e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568926115    96 DGHSLLHWAALGGNADVCQILIENKINPNV 125
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 96-127 3.19e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 3.19e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568926115   96 DGHSLLHWAAL-GGNADVCQILIENKINPNVQD 127
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 130-161 3.88e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 3.88e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568926115  130 GRTPLQCAAY-GGYINCMAVLMENNADPNIQDK 161
Cdd:pfam00023   2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 162-190 4.66e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 4.66e-04
                           10        20
                   ....*....|....*....|....*....
gi 568926115   162 EGRTALHWSCNNGYLDAIKLLLDFAAFPN 190
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 285-536 5.75e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 5.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  285 GQLDTDPPRSHCSSSAPVLPcPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRK 364
Cdd:PHA03307  107 TPPGPSSPDPPPPTPPPASP-PPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARA 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  365 PSETPIEHCRGPSACVHPRSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEEGPSSARQPLCTGSGRPAEKGEDSSPAVAS 444
Cdd:PHA03307  186 PSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITL 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  445 ASQQDHPRKPNKRQDRA--ARPRGASqkrrthqlRDRCSPAGSSRPGSakGEVACADQSSLHRHTPRSkvtqdkliggVS 522
Cdd:PHA03307  266 PTRIWEASGWNGPSSRPgpASSSSSP--------RERSPSPSPSSPGS--GPAPSSPRASSSSSSSRE----------SS 325

                         250
                  ....*....|....
gi 568926115  523 SGLPLSTEASRSGC 536
Cdd:PHA03307  326 SSSTSSSSESSRGA 339
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 96-125 7.94e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.24  E-value: 7.94e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 568926115   96 DGHSLLHWAALGGNADVCQILIENKINPNV 125
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 130-158 8.83e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 8.83e-04
                           10        20
                   ....*....|....*....|....*....
gi 568926115   130 GRTPLQCAAYGGYINCMAVLMENNADPNI 158
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 227-253 9.55e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 37.14  E-value: 9.55e-04
                         10        20
                 ....*....|....*....|....*..
gi 568926115 227 AIQDIAAFKIQAVYKGYKVRKAFRDRK 253
Cdd:cd23767    6 QRMNRAATLIQALWRGYKVRKELKKKK 32
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 33-59 1.55e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 1.55e-03
                           10        20
                   ....*....|....*....|....*..
gi 568926115    33 TALHAAALSGHVSTVKLLLDNDAQVDA 59
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 79-255 2.14e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  79 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNI 158
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINK 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 159 QDkegrTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGER-HEVIQFMLEHGAlsiaaiqDIAAFKIQ 237
Cdd:PHA02876 240 ND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN--TPLHHASQAPSlSRLVPKLLERGA-------DVNAKNIK 306

                        170
                 ....*....|....*...
gi 568926115 238 AVYKGYKVRKAFRDRKNL 255
Cdd:PHA02876 307 GETPLYLMAKNGYDTENI 324
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 30-59 2.25e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 2.25e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568926115   30 YGGTALHAAALSGHVSTVKLLLDNDAQVDA 59
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 229-479 2.86e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.04  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 229 QDIAAFKI---QAVYKGYKVRKAFRDRKNLLMKH-EQLRKDAAAKKREEENKRKEAEQQKGQLDTDPPRSHCSSSAPVLP 304
Cdd:PRK12678  21 GGLAGMKLpelRALAKQLGIKGTSGMRKGELIAAiKEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 305 CPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCP----GRASQGDSSIDLQGTASRKPSETPIEHCRGPSACV 380
Cdd:PRK12678 101 KAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAarkaGEGGEQPATEARADAAERTEEEERDERRRRGDRED 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 381 HPRSWEGGNSSKNQGTSSvEKRRGETNGKHRRCEEGPSSARQplctGSGRPAEKGEDSSPAVASASQQDHPRKPNKRQDR 460
Cdd:PRK12678 181 RQAEAERGERGRREERGR-DGDDRDRRDRREQGDRREERGRR----DGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDG 255

                        250
                 ....*....|....*....
gi 568926115 461 AARPRGASQKRRThqlRDR 479
Cdd:PRK12678 256 EGRGGRRGRRFRD---RDR 271
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 10-171 2.92e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.02  E-value: 2.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  10 DVLRTMLSLKSDIDINMSDKY--GGTALHAAALSGHVSTVKLLLDNDAQVDAT---DVMKHTPL-----------FRACe 73
Cdd:cd21882   50 EAAPDSGNPKELVNAPCTDEFyqGQTALHIAIENRNLNLVRLLVENGADVSARatgRFFRKSPGnlfyfgelplsLAAC- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  74 MGHRDVIQTLIKGGARV-DLVDQD--GHSLLHWAALGGN------ADVCQ-----ILIENKINPNVQ-----DYAGRTPL 134
Cdd:cd21882  129 TNQEEIVRLLLENGAQPaALEAQDslGNTVLHALVLQADntpensAFVCQmynllLSYGAHLDPTQQleeipNHQGLTPL 208

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 568926115 135 QCAAYGGYINCMAVLMENNADPNIQDKEgRTALHWSC 171
Cdd:cd21882  209 KLAAVEGKIVMFQHILQREFSGPYQPLS-RKFTEWTY 244
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 312-555 3.96e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  312 EASKQDATPSKQPPASHTVQSPDPeHSRPPGRCPGRASQGDSSIDLQGTASRKPSETPIEHCRGPSACVHPRsweggNSS 391
Cdd:PHA03307   12 EAAAEGGEFFPRPPATPGDAADDL-LSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPAN-----ESR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  392 KNQGTSSVEKRRGETNGKHRRCEEGPSSARQPLCTGSgrPAEKGEDSSPAVASASQQDHPRKPNKRQDRAARPRGASQKR 471
Cdd:PHA03307   86 STPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP--PASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115  472 RTHQlrdrcSPAGSSRPGSAKGEVACADQS---------SLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRSGCKQLYED 542
Cdd:PHA03307  164 SDAA-----SSRQAALPLSSPEETARAPSSppaepppstPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238

                         250
                  ....*....|...
gi 568926115  543 ICASPETGVAHGP 555
Cdd:PHA03307  239 SSSSESSGCGWGP 251
C11orf65 cd21090
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ...
 588-634 5.08e-03

chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.


Pssm-ID: 411042  Cd Length: 260  Bit Score: 39.23  E-value: 5.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568926115 588 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 634
Cdd:cd21090    4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 207-408 5.52e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.93  E-value: 5.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 207 LGERHEVIQ--FMLEHGALSIAAIQDIAAF--------KIQAVYKgykvrkaFRDRKNLLMKHEQLRKD---AAAKKREE 273
Cdd:PRK14954 316 LIERPESVKerYQQSAGGLTPAAVMQMTDFlmktqgelKFQFEYQ-------FRFELALLRLIELVRNDggvAPSPAGSP 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926115 274 ENKRKEAEQQKGQLDTDPPRSHCSSSA--PVLPCPPSpqneaskQDATPSKQPPashtVQSPDPEHSRPPGRCPGRASQG 351
Cdd:PRK14954 389 DVKKKAPEPDLPQPDRHPGPAKPEAPGarPAELPSPA-------SAPTPEQQPP----VARSAPLPPSPQASAPRNVASG 457

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568926115 352 DSSIDLqGTASRKPSETPIEHCRGpsACVHPRSWEGGNSSKNQGTSSVEKRRGETNG 408
Cdd:PRK14954 458 KPGVDL-GSWQGKFMNFTRNGSRK--QPVQASSSDAAQTGVFEGVAELEKLRMEWNQ 511
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 162-191 6.35e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 6.35e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568926115  162 EGRTALHWSC-NNGYLDAIKLLLDFAAFPNQ 191
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNA 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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