NCBI Conserved Domain Search

Laminin G domain;

1221-1352

2.93e-51

Laminin G domain;

Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 177.12 E-value: 2.93e-51

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1221 FRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGE 1300
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568930477  1301 SPSGTDG-LNLDTKLYVGGLPEEqvATVLDRTSVGIGLKGCIRMLDINNQQLE 1352
Cdd:pfam00054   81 SPLGATTdLDVDGPLYVGGLPSL--GVKKRRLAISPSFDGCIRDVIVNGKPLD 131

Laminin_G_1

Laminin G domain;

1489-1624

5.41e-46

Laminin G domain;

Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 162.10 E-value: 5.41e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1489 FLARGPSGLLLYNGQKTDGkgDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVL 1568
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTER--DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568930477  1569 GESPKSRKvphTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLL 1624
Cdd:pfam00054   79 GESPLGAT---TDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131

Laminin_G_1

Laminin G domain;

1742-1872

1.80e-45

Laminin G domain;

Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 160.56 E-value: 1.80e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1742 RTEATQGLVLWIGKVGERaDYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGS 1821
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTER-DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568930477  1822 SPLGATQ-LDTDGALWLGGLQKLPVgQALPKAYGTGFVGCLRDVVVGHRQLH 1872
Cdd:pfam00054   81 SPLGATTdLDVDGPLYVGGLPSLGV-KKRRLAISPSFDGCIRDVIVNGKPLD 131

SEA

smart00200

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...

953-1077

4.12e-31

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.

Pssm-ID: 214554 Cd Length: 121 Bit Score: 119.05 E-value: 4.12e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477    953 ATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFD 1032
Cdd:smart00200    1 PTQSFGVSLSVLSVEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTDLKPDFVGTEVIEFRNGSVVVDLGLLFNE 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 568930477   1033 PTTAfqAPDVGQALLQQIQVSRpWALAVRRPlrEHVRFLDFDWFP 1077
Cdd:smart00200   81 GVTN--GQDVEEDLLQVIKQAA-YSLKITNV--NVVDVLDPDSAD 120

Laminin_EGF

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

627-669

6.36e-15

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

Pssm-ID: 395007 Cd Length: 49 Bit Score: 70.46 E-value: 6.36e-15

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568930477   627 CHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRG 669
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPS 43

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

323-368

1.04e-12

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 63.85 E-value: 1.04e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    323 ECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPC 368
Cdd:smart00280    1 DCPEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

388-433

1.69e-12

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 63.47 E-value: 1.69e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    388 VCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHC 433
Cdd:smart00280    1 DCPEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

30-76

1.87e-11

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 60.39 E-value: 1.87e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 568930477     30 VCKKNvCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPC 76
Cdd:smart00280    1 DCPEA-CPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

538-584

2.53e-11

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 60.00 E-value: 2.53e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 568930477    538 VCDFSCQSVLKsPVCGSDGVTYSTECHLKKARCEARQELYVAAQGAC 584
Cdd:smart00280    1 DCPEACPREYD-PVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

106-151

2.64e-10

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 57.30 E-value: 2.64e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    106 CPTTCFGAPDgTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPC 151
Cdd:smart00280    2 CPEACPREYD-PVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

453-498

9.06e-10

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 55.76 E-value: 9.06e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    453 VCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPC 498
Cdd:smart00280    1 DCPEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

756-803

1.24e-09

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 55.38 E-value: 1.24e-09

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 568930477    756 VCPTlTCPEaNSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPC 803
Cdd:smart00280    1 DCPE-ACPR-EYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

Laminin_EGF

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

681-717

2.74e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

Pssm-ID: 395007 Cd Length: 49 Bit Score: 54.28 E-value: 2.74e-09

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568930477   681 CSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDG 717
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPG 37

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

183-223

3.98e-09

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family.

Pssm-ID: 395004 Cd Length: 49 Bit Score: 53.83 E-value: 3.98e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568930477   183 CPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQC 223
Cdd:pfam00050    9 CPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

255-295

7.27e-09

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 53.04 E-value: 7.27e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  255 CDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPC 295
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

EGF_CA

cd00054

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

1646-1678

5.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.55 E-value: 5.61e-06

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568930477 1646 AVDNPCLNGGSCIPREATYECLCPGGFSGLHCE 1678
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Name

Accession

Description

Interval

E-value

Laminin_G_1

Laminin G domain;

1221-1352

2.93e-51

Laminin G domain;

Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 177.12 E-value: 2.93e-51

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1221 FRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGE 1300
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568930477  1301 SPSGTDG-LNLDTKLYVGGLPEEqvATVLDRTSVGIGLKGCIRMLDINNQQLE 1352
Cdd:pfam00054   81 SPLGATTdLDVDGPLYVGGLPSL--GVKKRRLAISPSFDGCIRDVIVNGKPLD 131

Laminin_G_1

Laminin G domain;

1489-1624

5.41e-46

Laminin G domain;

Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 162.10 E-value: 5.41e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1489 FLARGPSGLLLYNGQKTDGkgDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVL 1568
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTER--DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568930477  1569 GESPKSRKvphTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLL 1624
Cdd:pfam00054   79 GESPLGAT---TDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131

Laminin_G_1

Laminin G domain;

1742-1872

1.80e-45

Laminin G domain;

Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 160.56 E-value: 1.80e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1742 RTEATQGLVLWIGKVGERaDYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGS 1821
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTER-DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568930477  1822 SPLGATQ-LDTDGALWLGGLQKLPVgQALPKAYGTGFVGCLRDVVVGHRQLH 1872
Cdd:pfam00054   81 SPLGATTdLDVDGPLYVGGLPSLGV-KKRRLAISPSFDGCIRDVIVNGKPLD 131

LamG

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...

1198-1347

2.03e-45

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.

Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 161.05 E-value: 2.03e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477 1198 FKGHSFLAFPTLRA-YHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWH 1276
Cdd:cd00110     4 FSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWH 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568930477 1277 RLELSRHWRQGTLSVDGEAPVVGESPSGTDGLNLDTKLYVGGLPEEQVATvldRTSVGIGLKGCIRMLDIN 1347
Cdd:cd00110    84 SVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSP---GLPVSPGFVGCIRDLKVN 151

LamG

Laminin G domain;

1216-1349

1.30e-42

Laminin G domain;

Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 152.49 E-value: 1.30e-42

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477   1216 RLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTS-LVPVEPGRWHRLELSRHWRQGTLSVDGE 1294
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568930477   1295 APVVGESPSGTDGLNLDTKLYVGGLPEEQVATvldRTSVGIGLKGCIRMLDINNQ 1349
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLP---PLPVTPGFRGCIRNLKVNGK 132

LamG

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...

1461-1618

7.83e-35

Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 131.00 E-value: 7.83e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477 1461 FNGFSYLELKGLHTFERDlgekMALEMVFLARGPSGLLLYNGQKTdgKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPI 1540
Cdd:cd00110     4 FSGSSYVRLPTLPAPRTR----LSISFSFRTTSPNGLLLYAGSQN--GGDFLALELEDGRLVLRYDLGSGSLVLSSKTPL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568930477 1541 ALGTWVRVFLERNGRKGALQVgDGPRVLgESPKSRKvpHTMLNLKEPLYVGGAPDFSKLaRGAAVASGFDGAIQLVSL 1618
Cdd:cd00110    78 NDGQWHSVSVERNGRSVTLSV-DGERVV-ESGSPGG--SALLNLDGPLYLGGLPEDLKS-PGLPVSPGFVGCIRDLKV 150

LamG

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...

1722-1866

9.64e-33

Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 124.84 E-value: 9.64e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477 1722 DSRALFSEKALQSNHFELSL--RTEATQGLVLWIGkVGERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRV 1799
Cdd:cd00110     7 SSYVRLPTLPAPRTRLSISFsfRTTSPNGLLLYAG-SQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSV 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568930477 1800 RAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQklPVGQALPKAYGTGFVGCLRDVVV 1866
Cdd:cd00110    86 SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLP--EDLKSPGLPVSPGFVGCIRDLKV 150

LamG

Laminin G domain;

1736-1869

4.26e-32

Laminin G domain;

Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 122.45 E-value: 4.26e-32

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477   1736 HFELSLRTEATQGLVLWIGkVGERADYMALAIVDGHLQLSYDLGSQPVVLRST-VKVNTNRWLRVRAHREHREGSLQVGN 1814
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAG-SKGGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 568930477   1815 EAPVTGSSPLGATQLDTDGALWLGGlqkLPVGQALPK-AYGTGFVGCLRDVVVGHR 1869
Cdd:smart00282   80 GNRVSGESPGGLTILNLDGPLYLGG---LPEDLKLPPlPVTPGFRGCIRNLKVNGK 132

LamG

Laminin G domain;

1485-1621

1.10e-31

Laminin G domain;

Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 121.29 E-value: 1.10e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477   1485 LEMVFLARGPSGLLLYNGQKtdGKGDFVSLALHNRHLEFRYDLGKGAAIIRSK-EPIALGTWVRVFLERNGRKGALQVGD 1563
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSK--GGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 568930477   1564 GPRVLGESPKSrkvpHTMLNLKEPLYVGGAPDFSKLARGaAVASGFDGAIQLVSLRGH 1621
Cdd:smart00282   80 GNRVSGESPGG----LTILNLDGPLYLGGLPEDLKLPPL-PVTPGFRGCIRNLKVNGK 132

SEA

smart00200

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...

953-1077

4.12e-31

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.

Pssm-ID: 214554 Cd Length: 121 Bit Score: 119.05 E-value: 4.12e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477    953 ATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFD 1032
Cdd:smart00200    1 PTQSFGVSLSVLSVEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTDLKPDFVGTEVIEFRNGSVVVDLGLLFNE 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 568930477   1033 PTTAfqAPDVGQALLQQIQVSRpWALAVRRPlrEHVRFLDFDWFP 1077
Cdd:smart00200   81 GVTN--GQDVEEDLLQVIKQAA-YSLKITNV--NVVDVLDPDSAD 120

Laminin_EGF

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

627-669

6.36e-15

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

Pssm-ID: 395007 Cd Length: 49 Bit Score: 70.46 E-value: 6.36e-15

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568930477   627 CHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRG 669
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPS 43

EGF_Lam

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...

627-667

9.25e-15

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies

Pssm-ID: 238012 Cd Length: 50 Bit Score: 70.08 E-value: 9.25e-15

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  627 CHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNF 667
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42

EGF_Lam

Laminin-type epidermal growth factor-like domai;

627-669

1.40e-13

Laminin-type epidermal growth factor-like domai;

Pssm-ID: 214543 Cd Length: 46 Bit Score: 66.57 E-value: 1.40e-13

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568930477    627 CHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRG 669
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGP 43

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

323-368

1.04e-12

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 63.85 E-value: 1.04e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    323 ECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPC 368
Cdd:smart00280    1 DCPEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

388-433

1.69e-12

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 63.47 E-value: 1.69e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    388 VCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHC 433
Cdd:smart00280    1 DCPEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

30-76

1.87e-11

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 60.39 E-value: 1.87e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 568930477     30 VCKKNvCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPC 76
Cdd:smart00280    1 DCPEA-CPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

SEA

pfam01390

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...

971-1049

2.11e-11

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.

Pssm-ID: 460188 Cd Length: 100 Bit Score: 62.26 E-value: 2.11e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477   971 LFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWS---IRLRELGPGklVRAIVDVHFDPTTAFQAPDVGQ--- 1044
Cdd:pfam01390   12 LQYTPDLGNPSSQEFKSLSRRIESLLNELFRNSSLRKQYIKshvLRLRPDGGS--VVVDVVLVFRFPSTEPALDREKlie 89


                   ....*
gi 568930477  1045 ALLQQ 1049
Cdd:pfam01390   90 EILRQ 94

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

538-584

2.53e-11

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 60.00 E-value: 2.53e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 568930477    538 VCDFSCQSVLKsPVCGSDGVTYSTECHLKKARCEARQELYVAAQGAC 584
Cdd:smart00280    1 DCPEACPREYD-PVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

328-368

1.23e-10

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 58.05 E-value: 1.23e-10

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  328 CSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPC 368
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

36-76

1.63e-10

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 57.66 E-value: 1.63e-10

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477   36 CPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPC 76
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

106-151

2.64e-10

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 57.30 E-value: 2.64e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    106 CPTTCFGAPDgTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPC 151
Cdd:smart00280    2 CPEACPREYD-PVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

453-498

9.06e-10

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 55.76 E-value: 9.06e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    453 VCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPC 498
Cdd:smart00280    1 DCPEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

756-803

1.24e-09

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 55.38 E-value: 1.24e-09

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 568930477    756 VCPTlTCPEaNSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPC 803
Cdd:smart00280    1 DCPE-ACPR-EYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

393-433

1.32e-09

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 54.97 E-value: 1.32e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  393 CVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHC 433
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

Laminin_EGF

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

681-717

2.74e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

Pssm-ID: 395007 Cd Length: 49 Bit Score: 54.28 E-value: 2.74e-09

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568930477   681 CSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDG 717
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPG 37

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

183-223

3.98e-09

Pssm-ID: 395004 Cd Length: 49 Bit Score: 53.83 E-value: 3.98e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568930477   183 CPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQC 223
Cdd:pfam00050    9 CPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

454-498

4.41e-09

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 53.43 E-value: 4.41e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568930477  454 CPRCEHPppgpVCGSDGVTYLSACELREAACQQQVQIEEARAGPC 498
Cdd:cd00104     1 CPKEYDP----VCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

255-295

7.27e-09

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 53.04 E-value: 7.27e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  255 CDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPC 295
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

762-803

3.01e-08

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 51.12 E-value: 3.01e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568930477  762 CPEaNSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPC 803
Cdd:cd00104     1 CPK-EYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

549-584

3.88e-08

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 50.73 E-value: 3.88e-08

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568930477  549 SPVCGSDGVTYSTECHLKKARCEARQELYVAAQGAC 584
Cdd:cd00104     6 DPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

EGF_Lam

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...

680-717

5.10e-08

Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.82 E-value: 5.10e-08

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568930477  680 PCSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDG 717
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPG 38

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

250-295

7.20e-08

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 50.37 E-value: 7.20e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    250 CDRVtCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPC 295
Cdd:smart00280    2 CPEA-CPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

118-151

1.62e-07

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 49.19 E-value: 1.62e-07

                          10        20        30
                  ....*....|....*....|....*....|....
gi 568930477  118 VCGSDGVDYPSECQLLRHACANQEHIFKKFDGPC 151
Cdd:cd00104     8 VCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

539-576

2.20e-07

Pssm-ID: 400135 Cd Length: 50 Bit Score: 49.03 E-value: 2.20e-07

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568930477   539 CDFSCQSVLKSPVCGSDGVTYSTECHLKKARCEARQEL 576
Cdd:pfam07648    2 CNCQCPKTEYEPVCGSDGVTYPSPCALCAAGCKLGKEV 39

EGF_Lam

Laminin-type epidermal growth factor-like domai;

681-717

2.47e-07

Laminin-type epidermal growth factor-like domai;

Pssm-ID: 214543 Cd Length: 46 Bit Score: 48.85 E-value: 2.47e-07

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568930477    681 CSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDG 717
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPG 37

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

452-498

5.61e-06

Pssm-ID: 400135 Cd Length: 50 Bit Score: 45.18 E-value: 5.61e-06

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568930477   452 CVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARA---GPC 498
Cdd:pfam07648    1 NCNCQCPKTEYEPVCGSDGVTYPSPCALCAAGCKLGKEVKEEKVkydGSC 50

EGF_CA

cd00054

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

1646-1678

5.61e-06

Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.55 E-value: 5.61e-06

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568930477 1646 AVDNPCLNGGSCIPREATYECLCPGGFSGLHCE 1678
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

32-76

7.25e-06

Pssm-ID: 395004 Cd Length: 49 Bit Score: 44.58 E-value: 7.25e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568930477    32 KKNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPC 76
Cdd:pfam00050    5 PSGACPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

180-223

4.67e-05

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 42.28 E-value: 4.67e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568930477    180 PENCPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQC 223
Cdd:smart00280    3 PEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

328-368

4.82e-05

Pssm-ID: 395004 Cd Length: 49 Bit Score: 42.27 E-value: 4.82e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568930477   328 CSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPC 368
Cdd:pfam00050    9 CPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

183-223

1.12e-04

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 41.10 E-value: 1.12e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  183 CPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQC 223
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

386-425

1.99e-04

Pssm-ID: 400135 Cd Length: 50 Bit Score: 40.55 E-value: 1.99e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568930477   386 RCVCPsecVESAQPVCGSDGHTYASECELHVHACTHQISL 425
Cdd:pfam07648    3 NCQCP---KTEYEPVCGSDGVTYPSPCALCAAGCKLGKEV 39

EGF_CA

smart00179

Calcium-binding EGF-like domain;

1646-1678

2.14e-04

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 40.31 E-value: 2.14e-04

                            10        20        30
                    ....*....|....*....|....*....|....
gi 568930477   1646 AVDNPCLNGGSCIPREATYECLCPGGFS-GLHCE 1678
Cdd:smart00179    6 ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

758-803

2.54e-04

Pssm-ID: 395004 Cd Length: 49 Bit Score: 40.35 E-value: 2.54e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568930477   758 PTLTCPeANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPC 803
Cdd:pfam00050    5 PSGACP-RIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

106-151

2.83e-04

Pssm-ID: 400135 Cd Length: 50 Bit Score: 40.17 E-value: 2.83e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568930477   106 CPTTCFGAPDGTVCGSDGVDYPSECQLLRHACANQEHIFK---KFDGPC 151
Cdd:pfam07648    2 CNCQCPKTEYEPVCGSDGVTYPSPCALCAAGCKLGKEVKEekvKYDGSC 50

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

248-295

5.01e-04

Pssm-ID: 400135 Cd Length: 50 Bit Score: 39.78 E-value: 5.01e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568930477   248 CSCDRVTcdgaYRPVCAQDGHTYDNDCWRQQAECRQQQTI---PPKHQGPC 295
Cdd:pfam07648    4 CQCPKTE----YEPVCGSDGVTYPSPCALCAAGCKLGKEVkeeKVKYDGSC 50

EGF

pfam00008

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...

1648-1676

2.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

Pssm-ID: 394967 Cd Length: 31 Bit Score: 36.98 E-value: 2.66e-03

                           10        20
                   ....*....|....*....|....*....
gi 568930477  1648 DNPCLNGGSCIPREATYECLCPGGFSGLH 1676
Cdd:pfam00008    3 PNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

Name

Accession

Description

Interval

E-value

Laminin_G_1

Laminin G domain;

1221-1352

2.93e-51

Laminin G domain;

Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 177.12 E-value: 2.93e-51

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1221 FRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGE 1300
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568930477  1301 SPSGTDG-LNLDTKLYVGGLPEEqvATVLDRTSVGIGLKGCIRMLDINNQQLE 1352
Cdd:pfam00054   81 SPLGATTdLDVDGPLYVGGLPSL--GVKKRRLAISPSFDGCIRDVIVNGKPLD 131

Laminin_G_1

Laminin G domain;

1489-1624

5.41e-46

Laminin G domain;

Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 162.10 E-value: 5.41e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1489 FLARGPSGLLLYNGQKTDGkgDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVL 1568
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTER--DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568930477  1569 GESPKSRKvphTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLL 1624
Cdd:pfam00054   79 GESPLGAT---TDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131

Laminin_G_1

Laminin G domain;

1742-1872

1.80e-45

Laminin G domain;

Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 160.56 E-value: 1.80e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1742 RTEATQGLVLWIGKVGERaDYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGS 1821
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTER-DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568930477  1822 SPLGATQ-LDTDGALWLGGLQKLPVgQALPKAYGTGFVGCLRDVVVGHRQLH 1872
Cdd:pfam00054   81 SPLGATTdLDVDGPLYVGGLPSLGV-KKRRLAISPSFDGCIRDVIVNGKPLD 131

LamG

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...

1198-1347

2.03e-45

Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 161.05 E-value: 2.03e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477 1198 FKGHSFLAFPTLRA-YHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWH 1276
Cdd:cd00110     4 FSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWH 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568930477 1277 RLELSRHWRQGTLSVDGEAPVVGESPSGTDGLNLDTKLYVGGLPEEQVATvldRTSVGIGLKGCIRMLDIN 1347
Cdd:cd00110    84 SVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSP---GLPVSPGFVGCIRDLKVN 151

LamG

Laminin G domain;

1216-1349

1.30e-42

Laminin G domain;

Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 152.49 E-value: 1.30e-42

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477   1216 RLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTS-LVPVEPGRWHRLELSRHWRQGTLSVDGE 1294
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568930477   1295 APVVGESPSGTDGLNLDTKLYVGGLPEEQVATvldRTSVGIGLKGCIRMLDINNQ 1349
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLP---PLPVTPGFRGCIRNLKVNGK 132

LamG

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...

1461-1618

7.83e-35

Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 131.00 E-value: 7.83e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477 1461 FNGFSYLELKGLHTFERDlgekMALEMVFLARGPSGLLLYNGQKTdgKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPI 1540
Cdd:cd00110     4 FSGSSYVRLPTLPAPRTR----LSISFSFRTTSPNGLLLYAGSQN--GGDFLALELEDGRLVLRYDLGSGSLVLSSKTPL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568930477 1541 ALGTWVRVFLERNGRKGALQVgDGPRVLgESPKSRKvpHTMLNLKEPLYVGGAPDFSKLaRGAAVASGFDGAIQLVSL 1618
Cdd:cd00110    78 NDGQWHSVSVERNGRSVTLSV-DGERVV-ESGSPGG--SALLNLDGPLYLGGLPEDLKS-PGLPVSPGFVGCIRDLKV 150

LamG

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...

1722-1866

9.64e-33

Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 124.84 E-value: 9.64e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477 1722 DSRALFSEKALQSNHFELSL--RTEATQGLVLWIGkVGERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRV 1799
Cdd:cd00110     7 SSYVRLPTLPAPRTRLSISFsfRTTSPNGLLLYAG-SQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSV 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568930477 1800 RAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQklPVGQALPKAYGTGFVGCLRDVVV 1866
Cdd:cd00110    86 SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLP--EDLKSPGLPVSPGFVGCIRDLKV 150

LamG

Laminin G domain;

1736-1869

4.26e-32

Laminin G domain;

Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 122.45 E-value: 4.26e-32

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477   1736 HFELSLRTEATQGLVLWIGkVGERADYMALAIVDGHLQLSYDLGSQPVVLRST-VKVNTNRWLRVRAHREHREGSLQVGN 1814
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAG-SKGGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 568930477   1815 EAPVTGSSPLGATQLDTDGALWLGGlqkLPVGQALPK-AYGTGFVGCLRDVVVGHR 1869
Cdd:smart00282   80 GNRVSGESPGGLTILNLDGPLYLGG---LPEDLKLPPlPVTPGFRGCIRNLKVNGK 132

LamG

Laminin G domain;

1485-1621

1.10e-31

Laminin G domain;

Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 121.29 E-value: 1.10e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477   1485 LEMVFLARGPSGLLLYNGQKtdGKGDFVSLALHNRHLEFRYDLGKGAAIIRSK-EPIALGTWVRVFLERNGRKGALQVGD 1563
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSK--GGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 568930477   1564 GPRVLGESPKSrkvpHTMLNLKEPLYVGGAPDFSKLARGaAVASGFDGAIQLVSLRGH 1621
Cdd:smart00282   80 GNRVSGESPGG----LTILNLDGPLYLGGLPEDLKLPPL-PVTPGFRGCIRNLKVNGK 132

Laminin_G_2

pfam02210

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...

1221-1349

3.06e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.

Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 119.83 E-value: 3.06e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1221 FRALETEGLLLYNGNARGkDFLALALLDGHVQFRFDTGSGPAVLTSL-VPVEPGRWHRLELSRHWRQGTLSVDGEAPVVG 1299
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDLGSGPESLLSSgKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 568930477  1300 ESPSGTDGLNLDTKLYVGGLPEEqvaTVLDRTSVGIGLKGCIRMLDINNQ 1349
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126

SEA

smart00200

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...

953-1077

4.12e-31

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.

Pssm-ID: 214554 Cd Length: 121 Bit Score: 119.05 E-value: 4.12e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477    953 ATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFD 1032
Cdd:smart00200    1 PTQSFGVSLSVLSVEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTDLKPDFVGTEVIEFRNGSVVVDLGLLFNE 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 568930477   1033 PTTAfqAPDVGQALLQQIQVSRpWALAVRRPlrEHVRFLDFDWFP 1077
Cdd:smart00200   81 GVTN--GQDVEEDLLQVIKQAA-YSLKITNV--NVVDVLDPDSAD 120

Laminin_G_2

pfam02210

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...

1741-1869

3.10e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.

Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 108.28 E-value: 3.10e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1741 LRTEATQGLVLWIGkvGERADYMALAIVDGHLQLSYDLGSQPVVLRST-VKVNTNRWLRVRAHREHREGSLQVGNEAPVT 1819
Cdd:pfam02210    1 FRTRQPNGLLLYAG--GGGSDFLALELVNGRLVLRYDLGSGPESLLSSgKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 568930477  1820 GSSPLGATQLDTDGALWLGGLQKLPVGQALPkaYGTGFVGCLRDVVVGHR 1869
Cdd:pfam02210   79 SLPPGESLLLNLNGPLYLGGLPPLLLLPALP--VRAGFVGCIRDVRVNGE 126

Laminin_G_2

pfam02210

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...

1489-1621

1.45e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.

Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 89.02 E-value: 1.45e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  1489 FLARGPSGLLLYNGqktDGKGDFVSLALHNRHLEFRYDLGKGAAIIRS-KEPIALGTWVRVFLERNGRKGALQVGDGPRV 1567
Cdd:pfam02210    1 FRTRQPNGLLLYAG---GGGSDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568930477  1568 LGESPKsrkvPHTMLNLKEPLYVGGAPDFSKLaRGAAVASGFDGAIQLVSLRGH 1621
Cdd:pfam02210   78 SSLPPG----ESLLLNLNGPLYLGGLPPLLLL-PALPVRAGFVGCIRDVRVNGE 126

Laminin_EGF

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

627-669

6.36e-15

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

Pssm-ID: 395007 Cd Length: 49 Bit Score: 70.46 E-value: 6.36e-15

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568930477   627 CHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRG 669
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPS 43

EGF_Lam

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...

627-667

9.25e-15

Pssm-ID: 238012 Cd Length: 50 Bit Score: 70.08 E-value: 9.25e-15

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  627 CHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNF 667
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42

EGF_Lam

Laminin-type epidermal growth factor-like domai;

627-669

1.40e-13

Laminin-type epidermal growth factor-like domai;

Pssm-ID: 214543 Cd Length: 46 Bit Score: 66.57 E-value: 1.40e-13

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568930477    627 CHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRG 669
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGP 43

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

323-368

1.04e-12

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 63.85 E-value: 1.04e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    323 ECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPC 368
Cdd:smart00280    1 DCPEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

388-433

1.69e-12

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 63.47 E-value: 1.69e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    388 VCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHC 433
Cdd:smart00280    1 DCPEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

30-76

1.87e-11

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 60.39 E-value: 1.87e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 568930477     30 VCKKNvCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPC 76
Cdd:smart00280    1 DCPEA-CPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

SEA

pfam01390

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...

971-1049

2.11e-11

Pssm-ID: 460188 Cd Length: 100 Bit Score: 62.26 E-value: 2.11e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477   971 LFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWS---IRLRELGPGklVRAIVDVHFDPTTAFQAPDVGQ--- 1044
Cdd:pfam01390   12 LQYTPDLGNPSSQEFKSLSRRIESLLNELFRNSSLRKQYIKshvLRLRPDGGS--VVVDVVLVFRFPSTEPALDREKlie 89


                   ....*
gi 568930477  1045 ALLQQ 1049
Cdd:pfam01390   90 EILRQ 94

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

538-584

2.53e-11

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 60.00 E-value: 2.53e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 568930477    538 VCDFSCQSVLKsPVCGSDGVTYSTECHLKKARCEARQELYVAAQGAC 584
Cdd:smart00280    1 DCPEACPREYD-PVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

328-368

1.23e-10

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 58.05 E-value: 1.23e-10

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  328 CSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPC 368
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

36-76

1.63e-10

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 57.66 E-value: 1.63e-10

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477   36 CPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPC 76
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

106-151

2.64e-10

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 57.30 E-value: 2.64e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    106 CPTTCFGAPDgTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPC 151
Cdd:smart00280    2 CPEACPREYD-PVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

453-498

9.06e-10

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 55.76 E-value: 9.06e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    453 VCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPC 498
Cdd:smart00280    1 DCPEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

756-803

1.24e-09

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 55.38 E-value: 1.24e-09

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 568930477    756 VCPTlTCPEaNSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPC 803
Cdd:smart00280    1 DCPE-ACPR-EYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

393-433

1.32e-09

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 54.97 E-value: 1.32e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  393 CVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHC 433
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

Laminin_EGF

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

681-717

2.74e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.

Pssm-ID: 395007 Cd Length: 49 Bit Score: 54.28 E-value: 2.74e-09

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568930477   681 CSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDG 717
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPG 37

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

183-223

3.98e-09

Pssm-ID: 395004 Cd Length: 49 Bit Score: 53.83 E-value: 3.98e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568930477   183 CPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQC 223
Cdd:pfam00050    9 CPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

454-498

4.41e-09

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 53.43 E-value: 4.41e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568930477  454 CPRCEHPppgpVCGSDGVTYLSACELREAACQQQVQIEEARAGPC 498
Cdd:cd00104     1 CPKEYDP----VCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

255-295

7.27e-09

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 53.04 E-value: 7.27e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  255 CDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPC 295
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

762-803

3.01e-08

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 51.12 E-value: 3.01e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568930477  762 CPEaNSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPC 803
Cdd:cd00104     1 CPK-EYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

549-584

3.88e-08

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 50.73 E-value: 3.88e-08

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568930477  549 SPVCGSDGVTYSTECHLKKARCEARQELYVAAQGAC 584
Cdd:cd00104     6 DPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

EGF_Lam

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...

680-717

5.10e-08

Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.82 E-value: 5.10e-08

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568930477  680 PCSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDG 717
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPG 38

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

250-295

7.20e-08

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 50.37 E-value: 7.20e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568930477    250 CDRVtCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPC 295
Cdd:smart00280    2 CPEA-CPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

118-151

1.62e-07

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 49.19 E-value: 1.62e-07

                          10        20        30
                  ....*....|....*....|....*....|....
gi 568930477  118 VCGSDGVDYPSECQLLRHACANQEHIFKKFDGPC 151
Cdd:cd00104     8 VCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

539-576

2.20e-07

Pssm-ID: 400135 Cd Length: 50 Bit Score: 49.03 E-value: 2.20e-07

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568930477   539 CDFSCQSVLKSPVCGSDGVTYSTECHLKKARCEARQEL 576
Cdd:pfam07648    2 CNCQCPKTEYEPVCGSDGVTYPSPCALCAAGCKLGKEV 39

EGF_Lam

Laminin-type epidermal growth factor-like domai;

681-717

2.47e-07

Laminin-type epidermal growth factor-like domai;

Pssm-ID: 214543 Cd Length: 46 Bit Score: 48.85 E-value: 2.47e-07

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568930477    681 CSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDG 717
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPG 37

KAZAL_PSTI

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...

33-76

4.85e-06

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the superfamily of kazal-type proteinase inhibitors and follistatin-like proteins.

Pssm-ID: 238648 Cd Length: 45 Bit Score: 44.97 E-value: 4.85e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568930477   33 KNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPC 76
Cdd:cd01327     2 VFGCPKDYDPVCGTDGVTYSNECLLCAENLKRQTNIRIKHDGEC 45

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

452-498

5.61e-06

Pssm-ID: 400135 Cd Length: 50 Bit Score: 45.18 E-value: 5.61e-06

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568930477   452 CVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARA---GPC 498
Cdd:pfam07648    1 NCNCQCPKTEYEPVCGSDGVTYPSPCALCAAGCKLGKEVKEEKVkydGSC 50

EGF_CA

cd00054

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

1646-1678

5.61e-06

Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.55 E-value: 5.61e-06

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568930477 1646 AVDNPCLNGGSCIPREATYECLCPGGFSGLHCE 1678
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

32-76

7.25e-06

Pssm-ID: 395004 Cd Length: 49 Bit Score: 44.58 E-value: 7.25e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568930477    32 KKNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPC 76
Cdd:pfam00050    5 PSGACPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

KAZAL

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...

180-223

4.67e-05

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.

Pssm-ID: 197624 Cd Length: 46 Bit Score: 42.28 E-value: 4.67e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568930477    180 PENCPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQC 223
Cdd:smart00280    3 PEACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46

FSL_SPARC

cd01328

Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40 ...

301-356

4.78e-05

Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins such as collagen and vitronectin. The protein it composed of an N-terminal acidic region, a follistatin (FS) domain and an EF-hand calcium binding domain. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a small hydrophobic core of alpha/beta structure (Kazal domain) and has five disulfide bonds and a conserved N-glycosylation site. The FSL_SPARC domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.

Pssm-ID: 238649 [Multi-domain] Cd Length: 86 Bit Score: 43.62 E-value: 4.78e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  301 PCRGAQCAFGATCTV-KNGKAVCECQRVCSGGYDP---VCGSDGVTYGSVCELESMACTL 356
Cdd:cd01328     1 PCENHHCGAGKVCEVdDENTPKCVCIDPCPEEVDDrrkVCTNDNETFDSDCELYRTRCLC 60

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

328-368

4.82e-05

Pssm-ID: 395004 Cd Length: 49 Bit Score: 42.27 E-value: 4.82e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568930477   328 CSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPC 368
Cdd:pfam00050    9 CPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

41-76

6.10e-05

Pssm-ID: 400135 Cd Length: 50 Bit Score: 42.09 E-value: 6.10e-05

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568930477    41 APVCGSDASTYSNECELQRAQCNQQRRIR---LLRQGPC 76
Cdd:pfam07648   12 EPVCGSDGVTYPSPCALCAAGCKLGKEVKeekVKYDGSC 50

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

323-368

7.57e-05

Pssm-ID: 400135 Cd Length: 50 Bit Score: 42.09 E-value: 7.57e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568930477   323 ECQRVCSG-GYDPVCGSDGVTYGSVCELESMACTLGREIR---VARRGPC 368
Cdd:pfam07648    1 NCNCQCPKtEYEPVCGSDGVTYPSPCALCAAGCKLGKEVKeekVKYDGSC 50

KAZAL_FS

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...

183-223

1.12e-04

Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 41.10 E-value: 1.12e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  183 CPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQC 223
Cdd:cd00104     1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41

KAZAL_PSTI

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...

328-368

1.12e-04

Pssm-ID: 238648 Cd Length: 45 Bit Score: 41.12 E-value: 1.12e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  328 CSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPC 368
Cdd:cd01327     5 CPKDYDPVCGTDGVTYSNECLLCAENLKRQTNIRIKHDGEC 45

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

386-425

1.99e-04

Pssm-ID: 400135 Cd Length: 50 Bit Score: 40.55 E-value: 1.99e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568930477   386 RCVCPsecVESAQPVCGSDGHTYASECELHVHACTHQISL 425
Cdd:pfam07648    3 NCQCP---KTEYEPVCGSDGVTYPSPCALCAAGCKLGKEV 39

EGF_CA

smart00179

Calcium-binding EGF-like domain;

1646-1678

2.14e-04

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 40.31 E-value: 2.14e-04

                            10        20        30
                    ....*....|....*....|....*....|....
gi 568930477   1646 AVDNPCLNGGSCIPREATYECLCPGGFS-GLHCE 1678
Cdd:smart00179    6 ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

758-803

2.54e-04

Pssm-ID: 395004 Cd Length: 49 Bit Score: 40.35 E-value: 2.54e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568930477   758 PTLTCPeANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPC 803
Cdd:pfam00050    5 PSGACP-RIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

106-151

2.83e-04

Pssm-ID: 400135 Cd Length: 50 Bit Score: 40.17 E-value: 2.83e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568930477   106 CPTTCFGAPDGTVCGSDGVDYPSECQLLRHACANQEHIFK---KFDGPC 151
Cdd:pfam07648    2 CNCQCPKTEYEPVCGSDGVTYPSPCALCAAGCKLGKEVKEekvKYDGSC 50

FSL_SPARC

cd01328

Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40 ...

6-62

3.01e-04

Pssm-ID: 238649 [Multi-domain] Cd Length: 86 Bit Score: 41.31 E-value: 3.01e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477    6 CRGMLCGFGAVCEpsVEDPGRASCVCKKNvCPAMVAP---VCGSDASTYSNECELQRAQC 62
Cdd:cd01328     2 CENHHCGAGKVCE--VDDENTPKCVCIDP-CPEEVDDrrkVCTNDNETFDSDCELYRTRC 58

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

761-803

3.44e-04

Pssm-ID: 400135 Cd Length: 50 Bit Score: 40.17 E-value: 3.44e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568930477   761 TCPEANSTKVCGSDGVTYGNECQLKTIACRQRLDIS---IQSLGPC 803
Cdd:pfam07648    5 QCPKTEYEPVCGSDGVTYPSPCALCAAGCKLGKEVKeekVKYDGSC 50

KAZAL_PSTI

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...

757-803

4.24e-04

Pssm-ID: 238648 Cd Length: 45 Bit Score: 39.57 E-value: 4.24e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568930477  757 CPTLTCPeanstkVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPC 803
Cdd:cd01327     5 CPKDYDP------VCGTDGVTYSNECLLCAENLKRQTNIRIKHDGEC 45

Kazal_2

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

248-295

5.01e-04

Pssm-ID: 400135 Cd Length: 50 Bit Score: 39.78 E-value: 5.01e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568930477   248 CSCDRVTcdgaYRPVCAQDGHTYDNDCWRQQAECRQQQTI---PPKHQGPC 295
Cdd:pfam07648    4 CQCPKTE----YEPVCGSDGVTYPSPCALCAAGCKLGKEVkeeKVKYDGSC 50

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

550-584

5.64e-04

Pssm-ID: 395004 Cd Length: 49 Bit Score: 39.58 E-value: 5.64e-04

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568930477   550 PVCGSDGVTYSTECHLKKARCEARQELYVAAQGAC 584
Cdd:pfam00050   15 PVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

KAZAL_PSTI

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...

183-223

6.80e-04

Pssm-ID: 238648 Cd Length: 45 Bit Score: 39.19 E-value: 6.80e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568930477  183 CPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQC 223
Cdd:cd01327     5 CPKDYDPVCGTDGVTYSNECLLCAENLKRQTNIRIKHDGEC 45

FSL_SPARC

cd01328

Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40 ...

367-420

9.00e-04

Pssm-ID: 238649 [Multi-domain] Cd Length: 86 Bit Score: 40.15 E-value: 9.00e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930477  367 PCDRcGQCRFGSLCEV---ETGRCVCPSECVESAQP---VCGSDGHTYASECELHVHACT 420
Cdd:cd01328     1 PCEN-HHCGAGKVCEVddeNTPKCVCIDPCPEEVDDrrkVCTNDNETFDSDCELYRTRCL 59

EGF

cd00053

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...

1646-1678

1.72e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

Pssm-ID: 238010 Cd Length: 36 Bit Score: 37.84 E-value: 1.72e-03

                          10        20        30
                  ....*....|....*....|....*....|....
gi 568930477 1646 AVDNPCLNGGSCIPREATYECLCPGGFSG-LHCE 1678
Cdd:cd00053     3 AASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36

EGF

pfam00008

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...

1648-1676

2.66e-03

Pssm-ID: 394967 Cd Length: 31 Bit Score: 36.98 E-value: 2.66e-03

                           10        20
                   ....*....|....*....|....*....
gi 568930477  1648 DNPCLNGGSCIPREATYECLCPGGFSGLH 1676
Cdd:pfam00008    3 PNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

KAZAL_PSTI

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...

540-565

2.83e-03

Pssm-ID: 238648 Cd Length: 45 Bit Score: 37.26 E-value: 2.83e-03

                          10        20
                  ....*....|....*....|....*.
gi 568930477  540 DFSCQSVLKsPVCGSDGVTYSTECHL 565
Cdd:cd01327     2 VFGCPKDYD-PVCGTDGVTYSNECLL 26

Kazal_1

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...

253-295

3.81e-03

Pssm-ID: 395004 Cd Length: 49 Bit Score: 36.88 E-value: 3.81e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568930477   253 VTCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPC 295
Cdd:pfam00050    7 GACPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49

MFS_SLCO_OATP

cd17336

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...

387-457

5.57e-03

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 41.46 E-value: 5.57e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568930477  387 CVCPSEcveSAQPVCGSDGHTYASECelhvHA-CTHQISLYVASA-GHCqTCGETVCTFGAVCSAGQCVCPRC 457
Cdd:cd17336   316 CNCSDS---SFSPVCGSDGITYFSPC----HAgCTSSDAGNGTKTySNC-SCINSGTATSSGCPPDCSVAPNC 380

KAZAL_PSTI