Orange domain; This domain confers specificity among members of the Hairy/E(SPL) family.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907154260  334 QDYSEGYSWCLQEAVQFL-TLHAAS-DTQMKLLYHFQR 369
Cdd:smart00511   1 SSFRSGYRECANEVSRFLsQLPGTDpDVRARLLSHLQT 38

Helix-loop-helix DNA-binding domain;

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907154260 236 RLRKPVVEKMRRDRINSSIEQLKLLLEQefarHQPNSKLEKADILEMAVSYLKH 289
Cdd:pfam00010   2 REAHNERERRRRDRINDAFDELRELLPT----LPPDKKLSKAEILRLAIEYIKH 51

Orange domain; This domain confers specificity among members of the Hairy/E(SPL) family.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907154260  334 QDYSEGYSWCLQEAVQFL-TLHAAS-DTQMKLLYHFQR 369
Cdd:smart00511   1 SSFRSGYRECANEVSRFLsQLPGTDpDVRARLLSHLQT 38

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) family; The HES family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split (HES) proteins. They contain a basic helix-loop-helix (bHLH) domain with an invariant proline residue in its basic region, an orange domain in the central region and a conserved tetrapeptide motif, WRPW, at its C-terminal region. HES family proteins form heterodimers or homodimers via their HLH domain and bind DNA to repress gene transcription that play an essential role in development of both compartment and boundary cells of the central nervous system.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907154260 242 VEKMRRDRINSSIEQLKLLLEQEFARHQP-NSKLEKADILEMAVSYLKHSK 291
Cdd:cd11410     1 MEKKRRARINKSLEQLKTLVLEALNKDNTrYSKLEKADILEMTVKYLKQLQ 51

basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster protein hairy, protein deadpan and similar proteins; Protein hairy is a bHLH transcriptional repressor of genes that require a bHLH-O protein for their transcription. It acts as a pair-rule protein that regulates embryonic segmentation and adult bristle patterning. Protein deadpan is closely related to the product of the segmentation gene hairy. It is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907154260 233 EKNRLRKPVVEKMRRDRINSSIEQLK-LLLE---QEFARHqpnSKLEKADILEMAVSYLKH 289
Cdd:cd18913     1 ESRKSSKPIMEKRRRARINASLNELKsLLLDalkKDGTRH---SKLEKADILEMTVKHLRQ 58

basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster enhancer of split mbeta protein (ESMB) and similar proteins; ESMB, also termed E(spl)mbeta, or HLH-mbeta, or split locus enhancer protein mA, is a bHLH-O transcriptional repressor of genes that require a bHLH protein for their transcription. It is involved in the neural-epidermal lineage decision during early neurogenesis. The family also includes Enhancer of split m7 protein (also known as E(spl)m7), which acts as a transcriptional repressor that participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907154260 232 KEKNRLRKPVVEKMRRDRINSSIEQLKLLLEQEFAR-HQPNSKLEKADILEMAVSYLK 288
Cdd:cd19741     5 YQYRKVTKPLLERKRRARINKCLDELKDLMVEALATeAENVSKLEKADILELTVRHLK 62

basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins; HES-3, also termed Class B basic helix-loop-helix protein 43 (bHLHb43), or hairy and enhancer of split 3, is a bHLH-O transcription factor expressed in neural stem and progenitor cells that is involved in tissue regeneration. It regulates gene expression, cell growth, and insulin release. HES-3 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1907154260 242 VEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKH 289
Cdd:cd18933     1 MEKKRRARINVSLEQLKSLLEKHYSNNIRKRKLEKADILELTVKYLRS 48

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split HES-1, HES-4 and similar proteins; The family includes two bHLH-O transcriptional repressors, HES-1 and HES-4. HES-1, also termed Class B basic helix-loop-helix protein 39 (bHLHb39), or hairy homolog, or hairy-like protein (HL), plays an essential role in development of both compartment and boundary cells of the central nervous system. It regulates the maintenance of neural stem/progenitor cells by inhibiting proneural gene expression via Notch signaling. HES-4, also termed Class B basic helix-loop-helix protein 42 (bHLHb42), or bHLH factor Hes4, antagonizes the function of Twist-1 to regulate lineage commitment of bone marrow stromal/stem cells (BMSC). Epigenetic dysregulation of HES-4 is associated with striatal degeneration in postmortem Huntington brains. Both HES-1 and HES-4 are mammalian counterparts of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154260 233 EKNRLRKPVVEKMRRDRINSSIEQLKLL----LEQEFARHqpnSKLEKADILEMAVSYLK 288
Cdd:cd11459     1 EHRKSSKPIMEKRRRARINESLSQLKTLildaLKKDSSRH---SKLEKADILEMTVKHLR 57

helix loop helix domain;

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907154260  240 PVVEKMRRDRINSSIEQLKLLLEQefarHQPNSKLEKADILEMAVSYLKH 289
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPT----LPKNKKLSKAEILRLAIEYIKS 46

basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split (HES) proteins. The HERP (HES-related repressor protein) subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. Hairy and enhancer of split (HES)-related repressor protein (HERP) proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this subfamily. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression. The HES subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant proline residue in its basic region, an orange domain in the central region and a conserved tetrapeptide motif, WRPW, at its C-terminal region. They form heterodimers or homodimers via their HLH domain and bind DNA to repress gene transcription that play an essential role in development of both compartment and boundary cells of the central nervous system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1907154260 242 VEKMRRDRINSSIEQLKLLLeQEFARHQPNSKLEKADILEMAVSYLKH 289
Cdd:cd19685     1 SEKRRRQRINDKLNQLKELL-PPNLSKQSRSKLSKAEILEMAITELRR 47

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split-related protein HELT and similar proteins; HELT, also termed HES/HEY-like transcription factor, is a bHLH-O transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. HELT could homodimerize and heterodimerize with other bHLH-O protein such as HES-5 or HEY-2 and bound to E box to repress gene transcription.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1907154260 241 VVEKMRRDRINSSIEQLKLLLEQEFARhQPNSKLEKADILEMAVSYLK 288
Cdd:cd11408     4 VIEKRRRDRINRCLNELGKTVPMALAK-QTSGKLEKAEILEMTVQYLR 50

basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-6 and similar proteins; HES-6, also termed Class B basic helix-loop-helix protein 41 (bHLHb41), or hairy and enhancer of split 6, or C-HAIRY1, is a bHLH-O transcription factor that is expressed in developing muscle and involved in angiogenesis, myogenesis, neural differentiation and neurogenesis. HES-6 antagonizes Notch signaling but is not regulated by Notch signaling. It is a transcription co-factor associated with stem cell characteristics in neural tissue. It may act as an inhibitor of Hes-1 during neuronal development and forms a heterodimer with HES-1 to prevent its association with transcriptional co-repressors. The overexpression of HES-6 has been reported in metastatic cancers of different origins. HES-6 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907154260 236 RLRKPVVEKMRRDRINSSIEQLKLLLeqefARHQPNSKLEKADILEMAV 284
Cdd:cd11460     4 KARKPLVEKKRRARINESLQELRLIL----ADAELQSKMENAEVLELTV 48

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found in a large group of bHLH transcription regulators that are involved in gene expression responding to environmental change and controlling aspects of neural development, including proteins from aryl hydrocarbon receptor nuclear translocator (ARNT) family, hypoxia-inducible factor (HIF) family, aryl hydrocarbon receptor (AhR) family, neuronal PAS domain-containing protein (NPAS) family, Circadian locomotor output cycles protein kaput (CLOCK)-like family, and single-minded (SIM) family. bHLH-PAS transcriptional regulatory factors have a bHLH DNA-binding domain followed by two PAS domains and a C-terminal activation or repression domain. bHLH-PAS family members can be divided into class I and class II based on their dimerization partner. bHLH-PAS class I factors include AhR, HIF and SIM. The best characterized bHLH-PAS Class II protein is the ubiquitous ARNT. Some members of bHLH-PAS family act as transcriptional coactivators (such as NCoA) that lack the ability to dimerize and bind DNA.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907154260 236 RLRKPVVEKMRRDRINSSIEQLKLLLEQEFArhqPNSKLEKADILEMAVSYLK 288
Cdd:cd11391     1 REKSREAAKKRRDKENAEISELASLLPLPPA---VGSKLDKLSVLRLAVAYLR 50

Orange domain; This domain confers specificity among members of the Hairy/E(SPL) family.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907154260  334 QDYSEGYSWCLQEAVQFL-TLHAAS-DTQMKLLYHFQR 369
Cdd:smart00511   1 SSFRSGYRECANEVSRFLsQLPGTDpDVRARLLSHLQT 38

basic helix-loop-helix-orange (bHLH-O) domain found in differentially expressed in chondrocytes protein 2 (DEC2) and similar proteins; DEC2, also termed Class E basic helix-loop-helix protein 41 (bHLHe41), or Class B basic helix-loop-helix protein 3 (bHLHb3), or enhancer-of-split and hairy-related protein 1 (SHARP-1), is a bHLH-O transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907154260 232 KEKNRLRKPVVEKMRRDRINSSIEQLKLLLEqEFARHQPNSKLEKADILEMAVSYLK 288
Cdd:cd19750    12 KEAYKLPHRLIEKKRRDRINECIAQLKDLLP-EHLKLTTLGHLEKAVVLELTLKHLK 67

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) family; The ARNT family of bHLH-PAS transcription regulators includes ARNT, ARNT-like proteins (ARNTL and ARNTL2), and Drosophila melanogaster protein cycle. They act as the heterodimeric partner for bHLH-PAS proteins such as aryl hydrocarbon receptor (AhR), hypoxia-inducible factor (HIF), and single-minded (SIM). These bHLH-PAS transcription complexes are involved in transcriptional responses to xenobiotic, hypoxia, and developmental pathways. Heterodimerization of bHLH-PAS proteins with ARNT is mediated by contacts between both the bHLH and the tandem PAS domains. ARNT use bHLH and/or PAS domains to interact with several transcriptional coactivators. It is required for activity of the aryl hydrocarbon (dioxin) receptor. ARNTL, also termed Basic-helix-loop-helix-PAS protein MOP3, or brain and muscle ARNT-like 1 (BMAL1), or Class E basic helix-loop-helix protein 5 (bHLHe5), or member of PAS protein 3, or PAS domain-containing protein 3 (PASD3), or bHLH-PAS protein JAP3, is a member of the bHLH-PAS transcription factor family that forms heterodimers with another bHLH-PAS protein, CLOCK (circadian locomotor output cycle kaput), which regulates circadian rhythm. ARNTL-CLOCK heterodimer complex activates transcription from E-box (CANNTG) elements found in the promoter of circadian responsive genes. ARNTL is highly homologous to ARNT. ARNTL2, also termed Basic-helix-loop-helix-PAS protein MOP9, or brain and muscle ARNT-like 2 (BMAL2), or CYCLE-like factor (CLIF), or Class E basic helix-loop-helix protein 6 (bHLHe6), or member of PAS protein 9, or PAS domain-containing protein 9 (PASD9), is a neuronal bHLH-PAS transcriptional factor, regulating cell cycle progression and preventing cell death, whose sustained expression might ensure brain neuron survival. It also plays important roles in tumor angiogenesis. Protein cycle, also termed brain and muscle ARNT-like 1 (BMAL1), or MOP3, is a putative bHLH-PAS transcription factor involved in the generation of biological rhythms in Drosophila. It activates cycling transcription of Period (PER) and Timeless (TIM) by binding to the E-box (5'-CACGTG-3') present in their promoters.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907154260 242 VEKMRRDRINSSIEQLKLLLEQEFARhqpNSKLEKADILEMAVSYLKHSKGEP 294
Cdd:cd11437     8 IEKRRRDKMNAYIQELSALVPACNAM---SRKLDKLTVLRMAVQHLKSLRGTG 57

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1907154260 242 VEKMRRDRINSSIEQLKLLLEQEFaRHQPNSKLEKADILEMAVSYLKH 289
Cdd:cd11387     5 VERRRRDNINEKIQELGSLVPPSR-LETKDLKPNKGSILSKAVEYIRE 51

basic helix-loop-helix-orange (bHLH-O) domain found in differentially expressed in chondrocytes protein 1 (DEC1) and similar proteins; DEC1, also termed Class E basic helix-loop-helix protein 40 (bHLHe40), or Class B basic helix-loop-helix protein 2 (bHLHb2), or enhancer-of-split and hairy-related protein 2 (SHARP-2), or stimulated by retinoic acid gene 13 protein (STRA13), is a bHLH-O transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154260 232 KEKNRLRKPVVEKMRRDRINSSIEQLKLLLEqEFARHQPNSKLEKADILEMAvsyLKHSK 291
Cdd:cd19749    11 KDTYKLPHRLIEKKRRDRINECIAQLKDLLP-EHLKLTTLGHLEKAVVLELT---LKHVK 66

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907154260 233 EKNRLRKPVVEKMRRDRINSSIEQLKLLLEQefARHQPNSKLEKADILEMAVSYLKHSKGE 293
Cdd:cd11405     1 EQRRLSHISAEQKRRFNIKSGFDTLQSLIPS--LGQNPNQKVSKAAMLQKAAEYIKSLKRE 59

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907154260 243 EKMRRDRINSSIEQLKLLLeqefarhqPNS-KLEKADILEMAVSYLK 288
Cdd:cd11393     5 ERKRREKINERIRALRSLV--------PNGgKTDKASILDEAIEYIK 43

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 2 (ARNTL2) and similar proteins; ARNTL2, also termed Basic-helix-loop-helix-PAS protein MOP9, or brain and muscle ARNT-like 2 (BMAL2), or CYCLE-like factor (CLIF), or Class E basic helix-loop-helix protein 6 (bHLHe6), or member of PAS protein 9, or PAS domain-containing protein 9 (PASD9), is a neuronal bHLH-PAS transcriptional factor, regulating cell cycle progression and preventing cell death, whose sustained expression might ensure brain neuron survival. It also plays important roles in tumor angiogenesis. ARNT-2 heterodimerize with other bHLH-PAS proteins such as aryl hydrocarbon receptor (AhR), hypoxia-inducible factor (HIF), and single-minded (SIM).

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907154260 242 VEKMRRDRINSSIEQLKLLLEQefaRHQPNSKLEKADILEMAVSYLKHSKG 292
Cdd:cd11469     8 TEKRRRDKMNNLIEELSAMIPQ---CNPMARKLDKLTVLRMAVQHLKSLKG 55

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins; ARNTL, also termed Basic-helix-loop-helix-PAS protein MOP3, or brain and muscle ARNT-like 1 (BMAL1), or Class E basic helix-loop-helix protein 5 (bHLHe5), or member of PAS protein 3, or PAS domain-containing protein 3 (PASD3), or bHLH-PAS protein JAP3, is a member of the bHLH-PAS transcription factor family that forms heterodimers with another bHLH-PAS protein, CLOCK (circadian locomotor output cycle kaput), which regulates circadian rhythm. ARNTL-CLOCK heterodimer complex activates transcription from E-box (CANNTG) elements found in the promoter of circadian responsive genes. ARNTL is highly homologous to ARNT.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907154260 242 VEKMRRDRINSSIEQLKLLLEQEFARHQpnsKLEKADILEMAVSYLKHSKG 292
Cdd:cd11438    14 IEKRRRDKMNSFIDELASLVPTCNAMSR---KLDKLTVLRMAVQHMKTLRG 61

Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907154260 336 YSEGYSWCLQEAVQFLTLHAASDTQMK--LLYHFQR 369
Cdd:pfam07527   2 FRAGFNECANEVSRFLSTLEGVDPDLRqrLLNHLQR 37

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor (AhR) and similar proteins; AhR, also termed Ah receptor, or Dioxin receptor (DR), or Class E basic helix-loop-helix protein 76 (bHLHe76), is the only member of bHLH-PAS transcription regulators that bind and be activated by small chemical ligands. It is activated by Dioxin to control the expression of certain genes to influence biological processes such as apoptosis, proliferation, cell growth and differentiation. To form active DNA binding complexes AhR dimerize with a bHLH-PAS factor ARNT (Aryl hydrocarbon Nuclear Receptor Translocator).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907154260 244 KMRRDRINSSIEQLKLLL--EQEFArhqpnSKLEKADILEMAVSYLK 288
Cdd:cd11436    10 KRHRDRLNTELDRLASLLpfPQDVI-----SKLDKLSVLRLSVSYLR 51

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factors, USF1, USF2 and similar proteins; Upstream stimulatory factor 1 and 2 (USF-1 and USF-2) are members of bHLHzip transcription factor family. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907154260 242 VEKMRRDRINSSIEQL-KLLLEQEFArhQPNSKLEKADILEMAVSYLKH 289
Cdd:cd11396     5 VERRRRDKINNWIVKLaKIVPDCEKD--NSKQGQSKGGILSKACDYIQE 51