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Conserved domains on  [gi|568945928|ref|XP_006540123|]
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zinc finger protein 865 isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KREPA super family cl49620
Kinetoplastid RNA Editing Protein A (KREPA); The KREPA 1-6 (TbMP81, 63, 42, 24, 19, and 18, ...
 273-406 2.36e-07

Kinetoplastid RNA Editing Protein A (KREPA); The KREPA 1-6 (TbMP81, 63, 42, 24, 19, and 18, respectively) proteins are components of the RNA editing complex of parasitic protozoans such as Trypanosoma and Leishmania species. These parasites have a uniquely organized mitochondrial genome, the kinetoplast. Most kinetoplast-transcribed mRNAs are cryptic and encode multiple subunits for the electron transport chain following maturation through a uridine insertion/deletion process called RNA editing. KREPAs participate in the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. The editosome, a high molecular mass enzyme complex, carries out the reaction with the help of critical enzymes and structural proteins. Five related editosome proteins KREPA1 (TbMP81), KREPA2 (TbMP63), KREPA3 (TbMP42), KREPA4 (TbMP24), KREPA5 (TbMP19), and KREPA6 (TbMP18) play critical roles in the structure and auxiliary functions of the editing process without any predicted catalytic function. The KREPA1, KREPA2, and KREPA3 proteins contain C2H2 zinc finger motifs and KREPA4 and KREPA6, contain RNA-binding domains but all have a conserved C-terminal sequences that resemble an oligonucleotide-binding (OB)-fold domain. Thus, this group of five proteins is likely to be involved in protein-protein and/or protein-RNA interactions. RNA editing is crucial for the parasite's survival in both its bloodstream and procyclic form life cycle stages which allows the parasite to adapt to its environment and maintain its viability.


The actual alignment was detected with superfamily member cd23959:

Pssm-ID: 483960 [Multi-domain]  Cd Length: 424  Bit Score: 54.49  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  273 VPPTPTGGTPQPG-PALPSLGLPVSTASATASSDPAAVSSgPSATPATPATSTDGNTTPAAPPGVAMPPSATTGGDGPFA 351
Cdd:cd23959   145 APVTPFGQLPMFGqHPPPAKPLPAAAAAQQSSASPGEVAS-PFASGTVSASPFATATDTAPSSGAPDGFPAEASAPSPFA 223

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568945928  352 CSLCWKVFKKPSHLHQHQIihtgEKPFSCSVCSKSFNRRESLKRHVKT-HSADLLR 406
Cdd:cd23959   224 APASAASFPAAPVANGEAA----TPTHACTICGKAFSTHEGLRMHSKAkHGVELEK 275
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-583 3.41e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 3.41e-06
                           10        20
                   ....*....|....*....|...
gi 568945928   561 LKRHERIHTGEKPHQCPVCGKRF 583
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSF 24
PHA03378 super family cl33729
EBNA-3B; Provisional
 163-349 6.43e-05

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.98  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  163 PTPGPG--------------VASGLGTPTGTPGPLTTPSQTPPGPAVGAACDPTKDDKGYFRRLKYLMERrfPCGVCQKS 228
Cdd:PHA03378  565 PAPGLGplqiqpltspttsqLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMR--PLRMQPIT 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  229 F------------KQSSHLVQHMLVHSGERPYEcgicGRTYNHVSSLIRHRRCHKDVPPtPTGGTPQPGPALPSLGLPVS 296
Cdd:PHA03378  643 FnvlvfptphqppQVEITPYKPTWTQIGHIPYQ----PSPTGANTMLPIQWAPGTMQPP-PRAPTPMRPPAAPPGRAQRP 717

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568945928  297 TASATASSDPAAVSSG---PSATPAT---PATSTDGNTTPAAPPGVAMPPSATTGGDGP 349
Cdd:PHA03378  718 AAATGRARPPAAAPGRarpPAAAPGRarpPAAAPGRARPPAAAPGRARPPAAAPGAPTP 776
zf-H2C2_2 pfam13465
Zinc-finger double domain;
862-886 7.55e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 7.55e-03
                           10        20
                   ....*....|....*....|....*
gi 568945928   862 LMRHQRCHTEQRPYRCGVCGRGFLR 886
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 273-406 2.36e-07

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 54.49  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  273 VPPTPTGGTPQPG-PALPSLGLPVSTASATASSDPAAVSSgPSATPATPATSTDGNTTPAAPPGVAMPPSATTGGDGPFA 351
Cdd:cd23959   145 APVTPFGQLPMFGqHPPPAKPLPAAAAAQQSSASPGEVAS-PFASGTVSASPFATATDTAPSSGAPDGFPAEASAPSPFA 223

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568945928  352 CSLCWKVFKKPSHLHQHQIihtgEKPFSCSVCSKSFNRRESLKRHVKT-HSADLLR 406
Cdd:cd23959   224 APASAASFPAAPVANGEAA----TPTHACTICGKAFSTHEGLRMHSKAkHGVELEK 275
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
349-421 3.13e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 3.13e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568945928  349 PFACSLCWKVFKKPSHLHQHQIIHTGEKPFSCSV--CSKSFNRRESLKRHVKTHSADLLRLPCGICGKVFRDASY 421
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 272-343 9.45e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 9.45e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568945928  272 DVPPTPTGGTPQPGPALPSLGLPVSTASATASSDPAAVSSGPSATPATPATSTdGNTTPAAPPGVAMPPSAT 343
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPG-GPARPARPPTTAGPPAPA 2770
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-583 3.41e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 3.41e-06
                           10        20
                   ....*....|....*....|...
gi 568945928   561 LKRHERIHTGEKPHQCPVCGKRF 583
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSF 24
PHA03378 PHA03378
EBNA-3B; Provisional
 163-349 6.43e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.98  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  163 PTPGPG--------------VASGLGTPTGTPGPLTTPSQTPPGPAVGAACDPTKDDKGYFRRLKYLMERrfPCGVCQKS 228
Cdd:PHA03378  565 PAPGLGplqiqpltspttsqLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMR--PLRMQPIT 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  229 F------------KQSSHLVQHMLVHSGERPYEcgicGRTYNHVSSLIRHRRCHKDVPPtPTGGTPQPGPALPSLGLPVS 296
Cdd:PHA03378  643 FnvlvfptphqppQVEITPYKPTWTQIGHIPYQ----PSPTGANTMLPIQWAPGTMQPP-PRAPTPMRPPAAPPGRAQRP 717

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568945928  297 TASATASSDPAAVSSG---PSATPAT---PATSTDGNTTPAAPPGVAMPPSATTGGDGP 349
Cdd:PHA03378  718 AAATGRARPPAAAPGRarpPAAAPGRarpPAAAPGRARPPAAAPGRARPPAAAPGAPTP 776
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 276-344 1.09e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.11  E-value: 1.09e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928   276 TPTGGTPQPGPALPSLGLPVSTASATASSDPAAVSSGPSATPATP-ATSTDGNTTPAAPPGVAMPPSATT 344
Cdd:pfam17823  167 APHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGiSTAATATGHPAAGTALAAVGNSSP 236
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 220-242 7.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 7.14e-03
                           10        20
                   ....*....|....*....|...
gi 568945928   220 FPCGVCQKSFKQSSHLVQHMLVH 242
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
862-886 7.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 7.55e-03
                           10        20
                   ....*....|....*....|....*
gi 568945928   862 LMRHQRCHTEQRPYRCGVCGRGFLR 886
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 273-406 2.36e-07

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 54.49  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  273 VPPTPTGGTPQPG-PALPSLGLPVSTASATASSDPAAVSSgPSATPATPATSTDGNTTPAAPPGVAMPPSATTGGDGPFA 351
Cdd:cd23959   145 APVTPFGQLPMFGqHPPPAKPLPAAAAAQQSSASPGEVAS-PFASGTVSASPFATATDTAPSSGAPDGFPAEASAPSPFA 223

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568945928  352 CSLCWKVFKKPSHLHQHQIihtgEKPFSCSVCSKSFNRRESLKRHVKT-HSADLLR 406
Cdd:cd23959   224 APASAASFPAAPVANGEAA----TPTHACTICGKAFSTHEGLRMHSKAkHGVELEK 275
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
349-421 3.13e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 3.13e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568945928  349 PFACSLCWKVFKKPSHLHQHQIIHTGEKPFSCSV--CSKSFNRRESLKRHVKTHSADLLRLPCGICGKVFRDASY 421
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 272-343 9.45e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 9.45e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568945928  272 DVPPTPTGGTPQPGPALPSLGLPVSTASATASSDPAAVSSGPSATPATPATSTdGNTTPAAPPGVAMPPSAT 343
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPG-GPARPARPPTTAGPPAPA 2770
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-396 2.95e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  219 RFPCGVCQKSFKQSSHLVQHM--LVHSGE--RPYECGI--CGRTYNHVSSLIRHRRCHKDVPPTPTggTPQPGPAL---P 289
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE--KLLNSSSKfspL 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  290 SLGLPVSTASATASSDPAAVSSGPSatPATPATSTDGNTtpaappgvAMPPSATTGGDGP--FACSLCWKVFKKPSHLHQ 367
Cdd:COG5048   367 LNNEPPQSLQQYKDLKNDKKSETLS--NSCIRNFKRDSN--------LSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                         170       180
                  ....*....|....*....|....*....
gi 568945928  368 HQIIHTGEKPFSCSvCSKSFNRRESLKRH 396
Cdd:COG5048   437 HKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-583 3.41e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 3.41e-06
                           10        20
                   ....*....|....*....|...
gi 568945928   561 LKRHERIHTGEKPHQCPVCGKRF 583
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSF 24
PHA03378 PHA03378
EBNA-3B; Provisional
 163-349 6.43e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.98  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  163 PTPGPG--------------VASGLGTPTGTPGPLTTPSQTPPGPAVGAACDPTKDDKGYFRRLKYLMERrfPCGVCQKS 228
Cdd:PHA03378  565 PAPGLGplqiqpltspttsqLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMR--PLRMQPIT 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  229 F------------KQSSHLVQHMLVHSGERPYEcgicGRTYNHVSSLIRHRRCHKDVPPtPTGGTPQPGPALPSLGLPVS 296
Cdd:PHA03378  643 FnvlvfptphqppQVEITPYKPTWTQIGHIPYQ----PSPTGANTMLPIQWAPGTMQPP-PRAPTPMRPPAAPPGRAQRP 717

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568945928  297 TASATASSDPAAVSSG---PSATPAT---PATSTDGNTTPAAPPGVAMPPSATTGGDGP 349
Cdd:PHA03378  718 AAATGRARPPAAAPGRarpPAAAPGRarpPAAAPGRARPPAAAPGRARPPAAAPGAPTP 776
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 276-344 1.09e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.11  E-value: 1.09e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928   276 TPTGGTPQPGPALPSLGLPVSTASATASSDPAAVSSGPSATPATP-ATSTDGNTTPAAPPGVAMPPSATT 344
Cdd:pfam17823  167 APHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGiSTAATATGHPAAGTALAAVGNSSP 236
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 275-351 1.82e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 1.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928   275 PTPTGGTPQPGPALPSLGlPVSTASATASSDPAAVSSGPSATPATPATS--TDGNTTPAAPPGVAMP--PSATTGGDGPF 350
Cdd:pfam05109  523 PTPAVTTPTPNATSPTLG-KTSPTSAVTTPTPNATSPTPAVTTPTPNATipTLGKTSPTSAVTTPTPnaTSPTVGETSPQ 601


                   .
gi 568945928   351 A 351
Cdd:pfam05109  602 A 602
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-429 2.27e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  229 FKQSSHLVQHMLVHSGERPYECgICGRTYNHVSSLIRHRRCHKDVPPTPTGgTPQPGPALPSLGLPVSTASATASSdPAA 308
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSEN-SPLSSSYSIPSSSSDQNLENSSSSLPLT-TNSQLSPKSLLSQSPSSLSSSDSS-SSA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  309 VSSGPSATPatpatstdgNTTPAAPPGVAMPPSATTGGDGPFACSLCWKVFKKPSHL--HQHQIIHTGE--KPFSC--SV 382
Cdd:COG5048   258 SESPRSSLP---------TASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLtrHLRSVNHSGEslKPFSCpySL 328

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 568945928  383 CSKSFNRRESLKRHVKTHSADLLRLPC-GICGKVFRDASYLLKHQAAH 429
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEKlLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
548-593 6.43e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 6.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568945928  548 CGICGRAFGRRETLKRHERIHTGEKPHQCPVCGKRFRES------FHLSKHH 593
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelsRHLRTHH 87
PRK10856 PRK10856
cytoskeleton protein RodZ;
272-343 7.89e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 42.71  E-value: 7.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568945928  272 DVPPTPTGgTPQPGPALPSLGLPVSTASATASSDPAAVSSGPSATPATPATSTDGNTTPAAPPGVAMPPSAT 343
Cdd:PRK10856  181 PVDTTPTN-SQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAPLPTDQAGVSTPAADP 251
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
273-351 1.57e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 1.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568945928  273 VPPTPTGGTPQPGPAlpslglPVSTASATASSDPAAVSSGPSATPATPATSTDGNTTPAAPPGVAMPPSATTGGDGPFA 351
Cdd:PRK07003  372 VPARVAGAVPAPGAR------AAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAAD 444
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-389 1.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.58e-03
                           10        20
                   ....*....|....*....|...
gi 568945928   367 QHQIIHTGEKPFSCSVCSKSFNR 389
Cdd:pfam13465    4 RHMRTHTGEKPYKCPECGKSFKS 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 265-344 1.88e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  265 RHRRCHKDVPPTPTGGTPQpGPALPSLglPVSTASATASSDPAAVSSGP--------SATPATPATSTDGNTTPAAPPGV 336
Cdd:PHA03247 2663 RPRRARRLGRAAQASSPPQ-RPRRRAA--RPTVGSLTSLADPPPPPPTPepaphalvSATPLPPGPAAARQASPALPAAP 2739


                  ....*...
gi 568945928  337 AMPPSATT 344
Cdd:PHA03247 2740 APPAVPAG 2747
PRK10856 PRK10856
cytoskeleton protein RodZ;
276-344 5.16e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 40.39  E-value: 5.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568945928  276 TPTGGTPQPGPALPSLGLPVSTASATASSDPAAVSSGPSATPATPATSTdgNTTPAAPPGVAMPPSATT 344
Cdd:PRK10856  170 TDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVD--TAATPAPAAPATPDGAAP 236
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 378-400 5.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 5.37e-03
                           10        20
                   ....*....|....*....|...
gi 568945928   378 FSCSVCSKSFNRRESLKRHVKTH 400
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 274-349 5.40e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  274 PPTPTGGTPQPGPALPSLGLPVSTASATASSDPAAVSSG---------PSATPAT--PATSTDGNTTPAAPPGVAMPPSA 342
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAvlapaaalpPAASPAGplPPPTSAQPTAPPPPPGPPPPSLP 2851


                  ....*..
gi 568945928  343 TTGGDGP 349
Cdd:PHA03247 2852 LGGSVAP 2858
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
273-349 5.57e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 40.51  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  273 VPPTPTGGTPQPGPALPSLGLPVSTAS-----------ATASSDPAAVSSGPSATPATPAT--STDGNTTPAAPPGVAMP 339
Cdd:COG3469   122 VTSTTSSTAGSTTTSGASATSSAGSTTttttvsgtetaTGGTTTTSTTTTTTSASTTPSATttATATTASGATTPSATTT 201

                          90
                  ....*....|
gi 568945928  340 PSATTGGDGP 349
Cdd:COG3469   202 ATTTGPPTPG 211
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 272-322 5.67e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.82  E-value: 5.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568945928  272 DVPPTP--TGGTPQPGPALPSL----GLPVSTASATASSDPAAVSSGPSA-TPATPAT 322
Cdd:PRK14959  438 DAPPAPprSGIPPRPAPRMPEAspvpGAPDSVASASDAPPTLGDPSDTAEhTPSGPRT 495
PHA03247 PHA03247
large tegument protein UL36; Provisional
 274-354 6.83e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 6.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945928  274 PPTPTGGTPQP-GPALPSLGLPVSTASATASSDPA--AVSSGPSATPATPATSTDGNTTPAAPPGVAMPPSATTGGDGPF 350
Cdd:PHA03247 2712 PHALVSATPLPpGPAAARQASPALPAAPAPPAVPAgpATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASL 2791


                  ....
gi 568945928  351 ACSL 354
Cdd:PHA03247 2792 SESR 2795
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 220-242 7.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 7.14e-03
                           10        20
                   ....*....|....*....|...
gi 568945928   220 FPCGVCQKSFKQSSHLVQHMLVH 242
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
862-886 7.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 7.55e-03
                           10        20
                   ....*....|....*....|....*
gi 568945928   862 LMRHQRCHTEQRPYRCGVCGRGFLR 886
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 274-348 7.94e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.94e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568945928  274 PPTPTGGTPQPGPALPSLGLPVSTASATASSDPAAVSSGPSATPATPATSTDGNTTPAAPPGVAMPPSATTGGDG 348
Cdd:PRK07764  434 APAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADD 508
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 273-341 8.36e-03

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 39.36  E-value: 8.36e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568945928   273 VPPTPtggtPQPGPALPSLGLPVSTASATASSDPAAVSSGPSATPATPATSTDGNTTPAAPPGVAMPPS 341
Cdd:pfam16072  187 APAAA----PAPAPGAPQTPLAPLNPVAAAPAAAAGAAAAPVVAAAAPAAAAPPPPAPAAPPADAAPPA 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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