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Conserved domains on  [gi|568946142|ref|XP_006540229|]
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dynein axonemal assembly factor 3 isoform X1 [Mus musculus]

Protein Classification

DUF4470 and DUF4471 domain-containing protein( domain architecture ID 13864566)

protein containing domains DUF4470, DUF4471, and KLF18_N

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
 96-376 1.84e-152

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


:

Pssm-ID: 464292  Cd Length: 303  Bit Score: 437.86  E-value: 1.84e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142   96 LSLRLLKFRERDALEAVFRFWSGGEkgPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHIQEFRRW 175
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPE--SHPFDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  176 RDTGVAFELRDlSAYHVPNRTLASGRLLSHRGERVAARGYWGDIATGPFMAFGIEADDQSLLRTRNGQPVKTASEITQHN 255
Cdd:pfam14740  79 RETGVAFEFRE-GEYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  256 VTELFREVAAWR------------GPRAIQGNVEETESPEPDVPAQ-----------EPFTIHFLPLDSSQTLHHKTCYQ 312
Cdd:pfam14740 158 LLALFHELQTREpyehdstdsaryGSVQLLMTELLPEGEDSEEENTadddksdlitlPGVKVHFLPLDSLRKLPHKSKYR 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568946142  313 GRFQLLYVSCGMVHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIARVAGFAP 376
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKP 301
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
 11-64 7.46e-15

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


:

Pssm-ID: 464289  Cd Length: 97  Bit Score: 70.25  E-value: 7.46e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568946142   11 RRWTYRQK--FYVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLELWGNALL 64
Cdd:pfam14737  42 LPETYSGKlhITLNDRDPEVVARNILLLLILLEPDDNPGLDEAAELLLHLWYSAFL 97
PTZ00436 super family cl33183
60S ribosomal protein L19-like protein; Provisional
 402-524 3.62e-08

60S ribosomal protein L19-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00436:

Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 55.34  E-value: 3.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 402 SAVESGPAPSKVESTRAPLP-ESISPPQANQAPSLEAMSPPLADLAPPLETMCPPQANQAPPLEALSPSKADQIPPLEAM 480
Cdd:PTZ00436 203 AAAKKAAAPSGKKSAKAAAPaKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAA 282

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568946142 481 SPPQAKLVLPVEAISLPQADLASPPE-VISPLQEAMATSWVNAPP 524
Cdd:PTZ00436 283 APPAKAAAPPAKAAAAPAKAAAAPAKaAAAPAKAAAPPAKAAAPP 327
 
Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
 96-376 1.84e-152

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


Pssm-ID: 464292  Cd Length: 303  Bit Score: 437.86  E-value: 1.84e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142   96 LSLRLLKFRERDALEAVFRFWSGGEkgPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHIQEFRRW 175
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPE--SHPFDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  176 RDTGVAFELRDlSAYHVPNRTLASGRLLSHRGERVAARGYWGDIATGPFMAFGIEADDQSLLRTRNGQPVKTASEITQHN 255
Cdd:pfam14740  79 RETGVAFEFRE-GEYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  256 VTELFREVAAWR------------GPRAIQGNVEETESPEPDVPAQ-----------EPFTIHFLPLDSSQTLHHKTCYQ 312
Cdd:pfam14740 158 LLALFHELQTREpyehdstdsaryGSVQLLMTELLPEGEDSEEENTadddksdlitlPGVKVHFLPLDSLRKLPHKSKYR 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568946142  313 GRFQLLYVSCGMVHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIARVAGFAP 376
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKP 301
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
 11-64 7.46e-15

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


Pssm-ID: 464289  Cd Length: 97  Bit Score: 70.25  E-value: 7.46e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568946142   11 RRWTYRQK--FYVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLELWGNALL 64
Cdd:pfam14737  42 LPETYSGKlhITLNDRDPEVVARNILLLLILLEPDDNPGLDEAAELLLHLWYSAFL 97
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 402-524 3.62e-08

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 55.34  E-value: 3.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 402 SAVESGPAPSKVESTRAPLP-ESISPPQANQAPSLEAMSPPLADLAPPLETMCPPQANQAPPLEALSPSKADQIPPLEAM 480
Cdd:PTZ00436 203 AAAKKAAAPSGKKSAKAAAPaKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAA 282

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568946142 481 SPPQAKLVLPVEAISLPQADLASPPE-VISPLQEAMATSWVNAPP 524
Cdd:PTZ00436 283 APPAKAAAPPAKAAAAPAKAAAAPAKaAAAPAKAAAPPAKAAAPP 327
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 396-528 1.12e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.46  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  396 TPGGGDSAVESgPAPSKVESTRA---PLPESISPPQANQAPSLEAMSPPLADLAPPLETMCPPQANQAPPLEALSPSKAD 472
Cdd:pfam05109 491 SPSPRDNGTES-KAPDMTSPTSAvttPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNA 569

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568946142  473 QIPPLEAMSPPQAkLVLPVEAISLPQADLASPPEVIS--PLQEAMATSWVNAPPKHVT 528
Cdd:pfam05109 570 TIPTLGKTSPTSA-VTTPTPNATSPTVGETSPQANTTnhTLGGTSSTPVVTSPPKNAT 626
 
Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
 96-376 1.84e-152

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


Pssm-ID: 464292  Cd Length: 303  Bit Score: 437.86  E-value: 1.84e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142   96 LSLRLLKFRERDALEAVFRFWSGGEkgPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHIQEFRRW 175
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPE--SHPFDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  176 RDTGVAFELRDlSAYHVPNRTLASGRLLSHRGERVAARGYWGDIATGPFMAFGIEADDQSLLRTRNGQPVKTASEITQHN 255
Cdd:pfam14740  79 RETGVAFEFRE-GEYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  256 VTELFREVAAWR------------GPRAIQGNVEETESPEPDVPAQ-----------EPFTIHFLPLDSSQTLHHKTCYQ 312
Cdd:pfam14740 158 LLALFHELQTREpyehdstdsaryGSVQLLMTELLPEGEDSEEENTadddksdlitlPGVKVHFLPLDSLRKLPHKSKYR 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568946142  313 GRFQLLYVSCGMVHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIARVAGFAP 376
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKP 301
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
 11-64 7.46e-15

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


Pssm-ID: 464289  Cd Length: 97  Bit Score: 70.25  E-value: 7.46e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568946142   11 RRWTYRQK--FYVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLELWGNALL 64
Cdd:pfam14737  42 LPETYSGKlhITLNDRDPEVVARNILLLLILLEPDDNPGLDEAAELLLHLWYSAFL 97
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 402-524 3.62e-08

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 55.34  E-value: 3.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 402 SAVESGPAPSKVESTRAPLP-ESISPPQANQAPSLEAMSPPLADLAPPLETMCPPQANQAPPLEALSPSKADQIPPLEAM 480
Cdd:PTZ00436 203 AAAKKAAAPSGKKSAKAAAPaKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAA 282

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568946142 481 SPPQAKLVLPVEAISLPQADLASPPE-VISPLQEAMATSWVNAPP 524
Cdd:PTZ00436 283 APPAKAAAPPAKAAAAPAKAAAAPAKaAAAPAKAAAPPAKAAAPP 327
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 395-524 1.41e-07

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 53.80  E-value: 1.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 395 STPGGGDSAVESGPAPSKVESTRAPlpesiSPPQANQAPSLEAMSPPLADLAPPLETMCPPQANQAPPLEALSPSKADQI 474
Cdd:PTZ00436 209 AAPSGKKSAKAAAPAKAAAAPAKAA-----APPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAA 283

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568946142 475 PPLEAMSPPQAKLVLPVEAISLPQADLASPPEVISPLQEAMATSWVNAPP 524
Cdd:PTZ00436 284 PPAKAAAPPAKAAAAPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATP 333
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 396-528 1.12e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.46  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  396 TPGGGDSAVESgPAPSKVESTRA---PLPESISPPQANQAPSLEAMSPPLADLAPPLETMCPPQANQAPPLEALSPSKAD 472
Cdd:pfam05109 491 SPSPRDNGTES-KAPDMTSPTSAvttPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNA 569

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568946142  473 QIPPLEAMSPPQAkLVLPVEAISLPQADLASPPEVIS--PLQEAMATSWVNAPPKHVT 528
Cdd:pfam05109 570 TIPTLGKTSPTSA-VTTPTPNATSPTVGETSPQANTTnhTLGGTSSTPVVTSPPKNAT 626
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 379-504 5.48e-05

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 45.33  E-value: 5.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 379 ATKPSETFARFYKLGDSTPGGGDSAVESGPAPSKVEstrAPLPESISPPQANQAPSLEAMSPPLADLAPPLETMCPPQAN 458
Cdd:PTZ00436 226 AAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAA---APPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAKA 302

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 568946142 459 QAPPLEALSPSKADQIPPLEAMSPPQAKLVLPVEAISLPQADLASP 504
Cdd:PTZ00436 303 AAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 397-507 2.05e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 43.31  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 397 PGGGDSAVESGPAPSKVESTRAPLPESISPPQANQAPSlEAMSPPLADLAPPLETM---------CPPQANQAPPleals 467
Cdd:PHA02682  76 PSGQSPLAPSPACAAPAPACPACAPAAPAPAVTCPAPA-PACPPATAPTCPPPAVCpaparpapaCPPSTRQCPP----- 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568946142 468 pskadqIPPLEAMSP-PQAKLVLPVEAISLPQADLASPPEV 507
Cdd:PHA02682 150 ------APPLPTPKPaPAAKPIFLHNQLPPPDYPAASCPTI 184
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
330-506 2.09e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 330 PELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIARVAGFAPHTATKPSETFARFYKL------GDSTPGGGDSA 403
Cdd:PRK07003 360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRaeappaAPAPPATADRG 439

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 404 VESGPAPSkveSTRAPLPESISPPQANQAPSLEAMSPPLADLAPPLETMCPPQANQAPPLEALSPSKADQIPPLEAMSPP 483
Cdd:PRK07003 440 DDAADGDA---PVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAA 516

                        170       180
                 ....*....|....*....|...
gi 568946142 484 QAKLVLPVEAISLPQADLASPPE 506
Cdd:PRK07003 517 SREDAPAAAAPPAPEARPPTPAA 539
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 362-491 2.38e-04

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 43.40  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 362 SDRVVEIARVAGFAPHTATKPSETFARFYKLGDSTPGGGDSAVESGPAPSKVESTRA----PLPESISPPQANQAPSLEA 437
Cdd:PTZ00436 216 SAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAkaaaPPAKAAAPPAKAAAPPAKA 295

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568946142 438 MSPPLADLAPPLETMCPPQANQAPPLEALSPSKADQIPPLEAMSPPQAKLVLPV 491
Cdd:PTZ00436 296 AAAPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAPV 349
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
408-523 2.47e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 408 PAPSKVESTRAPLPESISPPQAnQAPSLEAMSPPLADLAPPLETMCPPQANQAPPLEALSPSKADQIPPLEAMSPPQAKL 487
Cdd:PRK12323 397 PAPAAPPAAPAAAPAAAAAARA-VAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAA 475

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568946142 488 VLPVEAISLPQADLASPPEVISPLQEAMATSWVNAP 523
Cdd:PRK12323 476 AAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAP 511
PHA03247 PHA03247
large tegument protein UL36; Provisional
 375-523 4.09e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  375 APHTATKPSETFARFYKLGDSTPGGGDSAVESGPAPSKVESTRAPLPESISP--------PQANQAPSLEAMSPPLADLA 446
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggDVRRRPPSRSPAAKPAAPAR 2880

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568946142  447 PPLETMCPPQANQAPPLEALSPSKADQIPPLEAMSPPQAKLVLPVEAisLPQADLASPPEVISPLQEAMATSWVNAP 523
Cdd:PHA03247 2881 PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPP--QPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955
PHA03247 PHA03247
large tegument protein UL36; Provisional
 368-524 4.20e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 4.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  368 IARVAGFA-PHTATKPSETFARFYKLGDSTPGGGDSAVESGPAPSKVESTRAPLPESISPPQANQAPSLEAMSPPLADLA 446
Cdd:PHA03247 2692 VGSLTSLAdPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568946142  447 PPLETMCPPQANQAPPLEALSPSKADQIPPLEAMSPPQAklvLPVEAISLPQADLASPPEVISPLQEAMATSWVNAPP 524
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP 2846
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
329-519 6.20e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 6.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 329 SPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIARVAGFAPHTATKPSETFARFYKLGDSTPGGGdSAVESGP 408
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGA-PAPAPAP 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 409 APSKVESTRAPLPESISPPQANQAPSLEA-----------MSPPLADLAPPLETMCPPQANQAPPLEALS----PSKADQ 473
Cdd:PRK12323 455 AAAPAAAARPAAAGPRPVAAAAAAAPARAapaaapapaddDPPPWEELPPEFASPAPAQPDAAPAGWVAEsipdPATADP 534

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 568946142 474 IPPLEAMSPPQAKLVLPVEAISLPQADLASPPEVISP-LQEAMATSW 519
Cdd:PRK12323 535 DDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASgLPDMFDGDW 581
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 406-518 1.27e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142  406 SGPAPSKVESTRAPlpesisPPQANQAPSLEAMSPPLADlAPPLETMCPPQANQAPPLEALSPSKADQIPPLEAMSPPQA 485
Cdd:pfam03154 379 SGPSPFQMNSNLPP------PPALKPLSSLSTHHPPSAH-PPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTS 451

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568946142  486 KLVLPVEAISLPQADL--ASPPEVISPLQEAMATS 518
Cdd:pfam03154 452 GLHQVPSQSPFPQHPFvpGGPPPITPPSGPPTSTS 486
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
397-523 1.76e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 397 PGGGDSavESGPAPSKVESTRAPLPESISPPQANQAPS-LEAMSPPLADLAPPLETMCPPQANQAPPLEALSPSK-ADQI 474
Cdd:PRK12323 365 PGQSGG--GAGPATAAAAPVAQPAPAAAAPAAAAPAPAaPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARqASAR 442

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568946142 475 PPLEAMSPPQAKLVLPVEAISLPQADLASPPEVISPLQEAMATSWVNAP 523
Cdd:PRK12323 443 GPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP 491
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 369-486 2.07e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 40.32  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 369 ARVAGFAPHTATKPSETFARFYKLGDSTPGGGDSAVESGPAPSKVEStrAPLPESISPPQANQAPSlEAMSPPLADLAPP 448
Cdd:PTZ00436 237 AKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAA--PPAKAAAPPAKAAAAPA-KAAAAPAKAAAAP 313

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568946142 449 LETMCPPQANQAPPLEALSPSKADQIPPLEAMSPPQAK 486
Cdd:PTZ00436 314 AKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAPVGK 351
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 397-493 7.62e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 39.14  E-value: 7.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946142 397 PGGGDSAVESGPAPSKVESTRAPLPESISPPQANQAPSLEAMSPPLA--DLAPPLE-TMCPPQANQA--PPLEALS-PSK 470
Cdd:PLN03209 330 PKESDAADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAyeDLKPPTSpIPTPPSSSPAssKSVDAVAkPAE 409

                         90       100
                 ....*....|....*....|...
gi 568946142 471 ADQIPPLEAMSPPQAKLVLPVEA 493
Cdd:PLN03209 410 PDVVPSPGSASNVPEVEPAQVEA 432
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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