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Conserved domains on  [gi|578801005|ref|XP_006711411|]
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bolA-like protein 1 isoform X1 [Homo sapiens]

Protein Classification

BolA family protein( domain architecture ID 10000955)

BolA family protein may be a stress-responsive transcriptional regulator and may also participate in iron metabolism; similar to mammalian BolA-like proteins that act as iron-sulfur (Fe-S) cluster assembly factors that facilitate [2Fe-2S] cluster insertion into a subset of cytosolic proteins, and to Haemophilus influenzae DNA-binding transcriptional regulator BolA

CATH:  3.30.300.90

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 31-116 5.35e-41

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 440041  Cd Length: 90  Bit Score: 131.46  E-value: 5.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801005  31 PVEAAIRTKLEEALSPEVLELRNESGGHAVPPG--SETHFRVAVVSSRFEGLSPLQRHRLVHAALAEELGGPVHALAIQA 108
Cdd:COG0271    2 SRQERIEEKLTAALAPEHLEVIDESHLHAGHAGagGESHFKVVIVSDAFAGKSRVARHRLVYAALADELAGGIHALAIHA 81


                 ....*...
gi 578801005 109 RTPAQWRE 116
Cdd:COG0271   82 YTPEEWQA 89
 
Name Accession Description Interval E-value
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 31-116 5.35e-41

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 131.46  E-value: 5.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801005  31 PVEAAIRTKLEEALSPEVLELRNESGGHAVPPG--SETHFRVAVVSSRFEGLSPLQRHRLVHAALAEELGGPVHALAIQA 108
Cdd:COG0271    2 SRQERIEEKLTAALAPEHLEVIDESHLHAGHAGagGESHFKVVIVSDAFAGKSRVARHRLVYAALADELAGGIHALAIHA 81


                 ....*...
gi 578801005 109 RTPAQWRE 116
Cdd:COG0271   82 YTPEEWQA 89
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 40-113 3.60e-36

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 118.71  E-value: 3.60e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578801005   40 LEEALSPEVLELRNESGGHAVPP-GSETHFRVAVVSSRFEGLSPLQRHRLVHAALAEELGGPVHALAIQARTPAQ 113
Cdd:pfam01722   1 LTEALAPTHLEVEDESHKHAGHAgGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGGIHALSIKTYTPEE 75
PRK11628 PRK11628
transcriptional regulator BolA; Provisional
 36-130 1.49e-27

transcriptional regulator BolA; Provisional


Pssm-ID: 183243  Cd Length: 105  Bit Score: 97.93  E-value: 1.49e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801005  36 IRTKLEEALSPEVLELRNESGGHAVPPGSETHFRVAVVSSRFEGLSPLQRHRLVHAALAEELGGPVHALAIQARTPAQWR 115
Cdd:PRK11628   7 IEEKLRAAFQPVFLEVVDESYRHNVPAGSESHFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTTVHALALHTYTIKEWE 86

                         90
                 ....*....|....*.
gi 578801005 116 E-NSQLDTSPPCLGGN 130
Cdd:PRK11628  87 GlQDTVFASPPCRGAG 102
 
Name Accession Description Interval E-value
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 31-116 5.35e-41

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 131.46  E-value: 5.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801005  31 PVEAAIRTKLEEALSPEVLELRNESGGHAVPPG--SETHFRVAVVSSRFEGLSPLQRHRLVHAALAEELGGPVHALAIQA 108
Cdd:COG0271    2 SRQERIEEKLTAALAPEHLEVIDESHLHAGHAGagGESHFKVVIVSDAFAGKSRVARHRLVYAALADELAGGIHALAIHA 81


                 ....*...
gi 578801005 109 RTPAQWRE 116
Cdd:COG0271   82 YTPEEWQA 89
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 40-113 3.60e-36

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 118.71  E-value: 3.60e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578801005   40 LEEALSPEVLELRNESGGHAVPP-GSETHFRVAVVSSRFEGLSPLQRHRLVHAALAEELGGPVHALAIQARTPAQ 113
Cdd:pfam01722   1 LTEALAPTHLEVEDESHKHAGHAgGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGGIHALSIKTYTPEE 75
PRK11628 PRK11628
transcriptional regulator BolA; Provisional
 36-130 1.49e-27

transcriptional regulator BolA; Provisional


Pssm-ID: 183243  Cd Length: 105  Bit Score: 97.93  E-value: 1.49e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801005  36 IRTKLEEALSPEVLELRNESGGHAVPPGSETHFRVAVVSSRFEGLSPLQRHRLVHAALAEELGGPVHALAIQARTPAQWR 115
Cdd:PRK11628   7 IEEKLRAAFQPVFLEVVDESYRHNVPAGSESHFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTTVHALALHTYTIKEWE 86

                         90
                 ....*....|....*.
gi 578801005 116 E-NSQLDTSPPCLGGN 130
Cdd:PRK11628  87 GlQDTVFASPPCRGAG 102
IbaG COG5007
Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];
34-120 2.47e-21

Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];


Pssm-ID: 444031  Cd Length: 81  Bit Score: 81.35  E-value: 2.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801005  34 AAIRTKLEEALSPEVLELrnESGGHavppgsetHFRVAVVSSRFEGLSPLQRHRLVHAALAEEL-GGPVHALAIQARTPA 112
Cdd:COG5007    4 EEIKQLIEAGLPCAEVEV--EGDGS--------HFEAIVVSDAFEGLSRVKRQQLVYAPLGDYIaSGEIHALSIKTYTPE 73


                 ....*...
gi 578801005 113 QWRENSQL 120
Cdd:COG5007   74 EWAAQRKL 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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