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Conserved domains on  [gi|578812376|ref|XP_006715392|]
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monocarboxylate transporter 10 isoform X1 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 70-316 1.84e-135

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17464:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 395  Bit Score: 389.92  E-value: 1.84e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17464    1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17464   81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGsgsslfSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17464  161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKK------RKFKCPPLKKIFNFNIWKSTGYRIWAFGIPAALFGYFV 234


                 ....*..
gi 578812376 310 PYVHLAK 316
Cdd:cd17464  235 PYVHLMN 241
 
Name Accession Description Interval E-value
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
 70-316 1.84e-135

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 389.92  E-value: 1.84e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17464    1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17464   81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGsgsslfSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17464  161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKK------RKFKCPPLKKIFNFNIWKSTGYRIWAFGIPAALFGYFV 234


                 ....*..
gi 578812376 310 PYVHLAK 316
Cdd:cd17464  235 PYVHLMN 241
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 67-318 2.76e-31

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 122.16  E-value: 2.76e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376   67 GGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDkmvfkTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAV 146
Cdd:TIGR00892  14 GGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSE-----TAWISSIMLAVLYAGGPISSILVNRFGCRPVVI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  147 VGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLID 226
Cdd:TIGR00892  89 AGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  227 SVGLFYTLRVLCIFMFVLFLAGFTYRPLATS-----TKDKESGGSGSSLFSRKKFSPPKKI---FNFAIFKVTAYAVWAV 298
Cdd:TIGR00892 169 SFGWRGSFLILGGLLLHCCVCGALMRPVGPSqrvskSKSKEGLPPDGSTKKLSKKSTAEKInrfLDFSLFTHRGFLVYLS 248

                         250       260
                  ....*....|....*....|
gi 578812376  299 GIPLALFGYFVPYVHLAKFS 318
Cdd:TIGR00892 249 GNVIMFLGFFAPIIFLVPYA 268
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
71-251 5.42e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 59.89  E-value: 5.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  71 WLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKmvfktAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAA 150
Cdd:COG2223    4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL-----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 151 VGFVGLMSSSFVSSIePLYLTYGIIFACGCSFAYQPSLVILGHYF-KKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:COG2223   79 LLGIGLLLLALAVSY-WLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157

                        170       180
                 ....*....|....*....|..
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTY 251
Cdd:COG2223  158 WRNAFLILGILLLVVAVLAWLF 179
MFS_1 pfam07690
Major Facilitator Superfamily;
116-307 1.73e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.79  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  116 WVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTyGIIFACGCSFAYQPSLVILGHYF 195
Cdd:pfam07690  36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVL-RVLQGLGAGALFPAALALIADWF 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  196 -KKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG---LFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLF 271
Cdd:pfam07690 115 pPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwraAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW 194

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 578812376  272 SRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGY 307
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230
 
Name Accession Description Interval E-value
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
 70-316 1.84e-135

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 389.92  E-value: 1.84e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17464    1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17464   81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGsgsslfSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17464  161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKK------RKFKCPPLKKIFNFNIWKSTGYRIWAFGIPAALFGYFV 234


                 ....*..
gi 578812376 310 PYVHLAK 316
Cdd:cd17464  235 PYVHLMN 241
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
 70-317 7.42e-124

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 360.69  E-value: 7.42e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17420    1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKLGDPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17420   81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSlFSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17420  161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRT-LHSRINLFLRKIFNVEIFKRKRYVIWALGIPLALFGYFV 239


                 ....*...
gi 578812376 310 PYVHLAKF 317
Cdd:cd17420  240 PYVHLMKF 247
MFS_MCT8 cd17465
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ...
 70-317 1.44e-80

Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341023 [Multi-domain]  Cd Length: 367  Bit Score: 249.33  E-value: 1.44e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17465    1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17465   81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRplatstkdkesggsgsslfsrkkfsppkkifnfaIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17465  161 LAHTFQVLSLFMFIQIFLSLTYK----------------------------------VFRRKTYRIWAFGIATAVLGYFV 206


                 ....*...
gi 578812376 310 PYVHLAKF 317
Cdd:cd17465  207 PYVHLMKY 214
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 70-318 2.96e-46

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 160.03  E-value: 2.96e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDddkmvFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17352    1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGEST-----SDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17352   76 LLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRplatstkdkesggsgsslfsrkkfsppkkifnfaIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17352  156 WRGALLILGGLCLNLCVCGLLLR----------------------------------LLKDPTFVLLALGVSFAMLGFFV 201


                 ....*....
gi 578812376 310 PYVHLAKFS 318
Cdd:cd17352  202 PFVYLPSYA 210
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 67-318 2.76e-31

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 122.16  E-value: 2.76e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376   67 GGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDkmvfkTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAV 146
Cdd:TIGR00892  14 GGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSE-----TAWISSIMLAVLYAGGPISSILVNRFGCRPVVI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  147 VGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLID 226
Cdd:TIGR00892  89 AGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  227 SVGLFYTLRVLCIFMFVLFLAGFTYRPLATS-----TKDKESGGSGSSLFSRKKFSPPKKI---FNFAIFKVTAYAVWAV 298
Cdd:TIGR00892 169 SFGWRGSFLILGGLLLHCCVCGALMRPVGPSqrvskSKSKEGLPPDGSTKKLSKKSTAEKInrfLDFSLFTHRGFLVYLS 248

                         250       260
                  ....*....|....*....|
gi 578812376  299 GIPLALFGYFVPYVHLAKFS 318
Cdd:TIGR00892 249 GNVIMFLGFFAPIIFLVPYA 268
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 70-315 1.80e-23

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 99.39  E-value: 1.80e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFgskddDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17423    1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYF-----EESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17423   76 LLSSLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRPLATSTKdkesggsgsslfSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17423  156 WRGALLLLSALSLHLVPCGALLRPLALPGD------------PPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFI 223


                 ....*.
gi 578812376 310 PYVHLA 315
Cdd:cd17423  224 PYVHLV 229
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
 70-210 1.19e-21

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 93.74  E-value: 1.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFgskddDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17429    1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEF-----QQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGG 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGS 210
Cdd:cd17429   76 ILTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGT 136
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
 70-213 2.02e-21

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 93.25  E-value: 2.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDkmvfkTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17430    1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSD-----TAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGG 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVF 213
Cdd:cd17430   76 LLASLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVF 139
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
 70-212 9.63e-18

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 82.90  E-value: 9.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDkmvfkTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17425    1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSE-----TSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGG 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSV 212
Cdd:cd17425   76 LLSGVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSI 138
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 70-212 1.72e-17

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 82.17  E-value: 1.72e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDdkmvfKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17428    1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKG-----MTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSG 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSV 212
Cdd:cd17428   76 FMVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSV 138
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 70-237 1.82e-16

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 79.02  E-value: 1.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFgskddDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17422    1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYF-----NETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17422   76 LLISLGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIG 155


                 ....*...
gi 578812376 230 LFYTLRVL 237
Cdd:cd17422  156 WRYCLLVV 163
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
 70-318 2.17e-16

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 79.15  E-value: 2.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDdkmvfKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17426    1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSS-----EVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17426   76 CLSGAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRPLAtstkdkesggsgsslfsrkkfspPKKIFNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17426  156 WRGSFLILGGLLLNCCVAGSLMRPIG-----------------------PKPFLDLTLFTHRGFLLYLSGNVIMFFGLFA 212


                 ....*....
gi 578812376 310 PYVHLAKFS 318
Cdd:cd17426  213 PLVFLSNYA 221
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
 70-254 1.42e-15

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 76.39  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFgskddDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17427    1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIF-----HTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17427   76 LLCSLGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFG 155

                        170       180
                 ....*....|....*....|....*
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRPL 254
Cdd:cd17427  156 WRGSFLILGGLLLNCCVAGSLMRPL 180
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
 70-314 2.94e-13

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 69.85  E-value: 2.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDdkmvfKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17421    1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSE-----QISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVfTILLPLLLRVLIDSVG 229
Cdd:cd17421   76 FLVSAGFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYD 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRPLatstkdkesggsgsslfsrkkfsppkkifNFAIFKVTAYAVWAVGIPLALFGYFV 309
Cdd:cd17421  155 WQGALLIFGGIMLNLVASGMLLRPI-----------------------------DFSLLKDPFFCIYTWSFVFSQLAYFI 205


                 ....*
gi 578812376 310 PYVHL 314
Cdd:cd17421  206 PYFHL 210
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 113-214 3.99e-13

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 69.07  E-value: 3.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 113 KTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILG 192
Cdd:cd17424   39 RTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVG 118

                         90       100
                 ....*....|....*....|..
gi 578812376 193 HYFKKRLGLVNGIVTAGSSVFT 214
Cdd:cd17424  119 KYFHKRKALAYGIAMSGSGIGT 140
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 71-252 8.41e-13

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 68.41  E-value: 8.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  71 WLVMLAAMWCNGsVFGIQNACGVLFVSMLETFGSKdddkmVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAA 150
Cdd:cd17353    3 WLVLLGAVLMHL-ILGYQYAWSVFNPPLSSALGWS-----LASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 151 VGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGL 230
Cdd:cd17353   77 LFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGV 156

                        170       180
                 ....*....|....*....|...
gi 578812376 231 FYTLRVL-CIFMFVLFLAGFTYR 252
Cdd:cd17353  157 PTTFLILgIIFLIIIVIGAFLIR 179
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
71-251 5.42e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 59.89  E-value: 5.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  71 WLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKmvfktAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAA 150
Cdd:COG2223    4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL-----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 151 VGFVGLMSSSFVSSIePLYLTYGIIFACGCSFAYQPSLVILGHYF-KKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:COG2223   79 LLGIGLLLLALAVSY-WLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157

                        170       180
                 ....*....|....*....|..
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTY 251
Cdd:COG2223  158 WRNAFLILGILLLVVAVLAWLF 179
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 70-254 6.61e-09

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 56.65  E-value: 6.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKdddkmVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGA 149
Cdd:cd17314    1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYS-----SSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 150 AVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG 229
Cdd:cd17314   76 IMVLAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYG 155

                        170       180
                 ....*....|....*....|....*
gi 578812376 230 LFYTLRVLCIFMFVLFLAGFTYRPL 254
Cdd:cd17314  156 LALVYTILGILAAIVLSVVSLLGFK 180
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 70-244 1.02e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 49.96  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  70 GWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGskdddkmvFKTAWVG---SLSMGMIFFCCPIVSVFTDLFGCRKTAV 146
Cdd:cd17355    1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFG--------WSRAVISlafTVGLLAFGLAQPFVGRLLDRFGPRRVML 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 147 VGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPS-LVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLI 225
Cdd:cd17355   73 LGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALI 152

                        170
                 ....*....|....*....
gi 578812376 226 DSVGLFYTLRVLCIFMFVL 244
Cdd:cd17355  153 EAFGWRTALLVLALLALLV 171
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
67-249 7.25e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.09  E-value: 7.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  67 GGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDkmvfkTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAV 146
Cdd:COG2271    5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQ-----LGLLASAFFLGYALGQIPAGLLADRFGRRRVLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 147 VGAAVGFVGLMSSSFVSSIEPLYLTYgIIFACGCSFAYQPSLVILGHYF-KKRLGLVNGIVTAGSSVFTILLPLLLRVLI 225
Cdd:COG2271   80 IGLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLL 158

                        170       180
                 ....*....|....*....|....
gi 578812376 226 DSVGLFYTLRVLCIFMFVLFLAGF 249
Cdd:COG2271  159 AAFGWRAAFLILGLPGLLLALLRF 182
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
114-247 1.54e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.94  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 114 TAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFAcGCSFAYQPSLVILGH 193
Cdd:COG2807   55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA-GIAVGNVLLPGLIKR 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578812376 194 YFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLA 247
Cdd:COG2807  134 WFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLL 187
MFS_1 pfam07690
Major Facilitator Superfamily;
116-307 1.73e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.79  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  116 WVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTyGIIFACGCSFAYQPSLVILGHYF 195
Cdd:pfam07690  36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVL-RVLQGLGAGALFPAALALIADWF 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376  196 -KKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG---LFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLF 271
Cdd:pfam07690 115 pPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwraAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW 194

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 578812376  272 SRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGY 307
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
115-276 2.52e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.27  E-value: 2.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 115 AWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLtYGIIFACGCSFAYQPSLVILGHY 194
Cdd:COG2814   48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 195 F-KKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSR 273
Cdd:COG2814  127 VpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRR 206


                 ...
gi 578812376 274 KKF 276
Cdd:COG2814  207 PRL 209
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 114-312 1.37e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.10  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 114 TAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGH 193
Cdd:cd06174   33 LGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812376 194 YFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGlfYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSR 273
Cdd:cd06174  113 FPERERGRALGLLQAFGSVGGILGPLLGGILASSLG--FGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK 190

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 578812376 274 KKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYV 312
Cdd:cd06174  191 SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLF 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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