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Conserved domains on  [gi|578813337|ref|XP_006715722|]
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thrombospondin type-1 domain-containing protein 7A isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 195-246 3.18e-17

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 76.93  E-value: 3.18e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578813337   195 CIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPC 246
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1287-1340 2.13e-15

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 71.54  E-value: 2.13e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 578813337  1287 CQLSDWSPWSECSQTCGlTGKMIRRRTVTQPFQGDGRPCPSLMdQSKPCPVKPC 1340
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-GGVQTRTRTVIVEPQNGGRPCPELL-ERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 361-412 2.20e-12

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 63.07  E-value: 2.20e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578813337   361 CQVSEWSEWSPCSKTCHDmvspaGTRVRTRTIRQFPIGSEKECPEFEEKEPC 412
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGG-----GVQTRTRTVIVEPQNGGRPCPELLERRPC 47
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1036-1076 3.20e-11

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 59.60  E-value: 3.20e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 578813337  1036 CKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKL 1076
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL 41
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 772-828 1.55e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 52.28  E-value: 1.55e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 578813337   772 CIVTPYSDWTSCPSSCKEGdssirKQSRHRVIIQLPANGGRDCTdPLYEEKACEAPQ 828
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGG-----VQTRTRTVIVEPQNGGRPCP-ELLERRPCNLPP 51
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1415-1474 1.48e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 49.59  E-value: 1.48e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813337  1415 CYLKDWSSWSLCQLTCvngedlgFGGIQVRSRPVIIQELENQHLCPEQmLETKSCYDGQC 1474
Cdd:pfam19028    1 CVVSEWSEWSECSVTC-------GGGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1166-1217 3.20e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 48.43  E-value: 3.20e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578813337  1166 CVISEWGPWTQCVLPCNqSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNK 1217
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1099-1161 9.69e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.37  E-value: 9.69e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578813337  1099 WVTEPWSICKVTfvnmrenCGEGVQTRKVRCMQntADGPSEhVEDYLCDPEEMPLGSRVCKLP 1161
Cdd:pfam19030    1 WVAGPWGECSVT-------CGGGVQTRLVQCVQ--KGGGSI-VPDSECSAQKKPPETQSCNLK 53
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 699-767 2.94e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 2.94e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813337   699 WQTGPWGQCiedtsvssfnttttwngEASCSVGMQTRKVICVRVNVGQ-VGPKKCPESLRPETVRPCLLP 767
Cdd:pfam19030    1 WVAGPWGEC-----------------SVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLK 53
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 513-573 4.33e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 42.27  E-value: 4.33e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578813337   513 CEVSPWSAWGPCTYEnCNdqqgkKGFKLRKRRITNEPTGGSgvtGNCPHLLEAIPCEEPAC 573
Cdd:pfam19028    1 CVVSEWSEWSECSVT-CG-----GGVQTRTRTVIVEPQNGG---RPCPELLERRPCNLPPC 52
 
Name Accession Description Interval E-value
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 195-246 3.18e-17

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 76.93  E-value: 3.18e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578813337   195 CIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPC 246
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1287-1340 2.13e-15

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 71.54  E-value: 2.13e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 578813337  1287 CQLSDWSPWSECSQTCGlTGKMIRRRTVTQPFQGDGRPCPSLMdQSKPCPVKPC 1340
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-GGVQTRTRTVIVEPQNGGRPCPELL-ERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 361-412 2.20e-12

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 63.07  E-value: 2.20e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578813337   361 CQVSEWSEWSPCSKTCHDmvspaGTRVRTRTIRQFPIGSEKECPEFEEKEPC 412
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGG-----GVQTRTRTVIVEPQNGGRPCPELLERRPC 47
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1036-1076 3.20e-11

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 59.60  E-value: 3.20e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 578813337  1036 CKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKL 1076
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL 41
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 772-828 1.55e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 52.28  E-value: 1.55e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 578813337   772 CIVTPYSDWTSCPSSCKEGdssirKQSRHRVIIQLPANGGRDCTdPLYEEKACEAPQ 828
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGG-----VQTRTRTVIVEPQNGGRPCP-ELLERRPCNLPP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 197-247 2.87e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 2.87e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578813337    197 VSEFSAWSECSKTCGSGLQHRTRHVV-APPQFGGSGCP-NLTEFQVCQSSPCE 247
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCsPPPQNGGGPCTgEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1290-1340 1.09e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.89  E-value: 1.09e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 578813337   1290 SDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC 1340
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1415-1474 1.48e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 49.59  E-value: 1.48e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813337  1415 CYLKDWSSWSLCQLTCvngedlgFGGIQVRSRPVIIQELENQHLCPEQmLETKSCYDGQC 1474
Cdd:pfam19028    1 CVVSEWSEWSECSVTC-------GGGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1166-1217 3.20e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 48.43  E-value: 3.20e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578813337  1166 CVISEWGPWTQCVLPCNqSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNK 1217
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1099-1161 9.69e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.37  E-value: 9.69e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578813337  1099 WVTEPWSICKVTfvnmrenCGEGVQTRKVRCMQntADGPSEhVEDYLCDPEEMPLGSRVCKLP 1161
Cdd:pfam19030    1 WVAGPWGECSVT-------CGGGVQTRLVQCVQ--KGGGSI-VPDSECSAQKKPPETQSCNLK 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 699-767 2.94e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 2.94e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813337   699 WQTGPWGQCiedtsvssfnttttwngEASCSVGMQTRKVICVRVNVGQ-VGPKKCPESLRPETVRPCLLP 767
Cdd:pfam19030    1 WVAGPWGEC-----------------SVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLK 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 513-573 4.33e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 42.27  E-value: 4.33e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578813337   513 CEVSPWSAWGPCTYEnCNdqqgkKGFKLRKRRITNEPTGGSgvtGNCPHLLEAIPCEEPAC 573
Cdd:pfam19028    1 CVVSEWSEWSECSVT-CG-----GGVQTRTRTVIVEPQNGG---RPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1039-1077 1.30e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 1.30e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 578813337   1039 SEWSNWSRCSKSCGSGVKVRSKW-LREKPYNGGRPCPKLD 1077
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRScCSPPPQNGGGPCTGED 41
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 363-412 1.68e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 1.68e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 578813337    363 VSEWSEWSPCSKTCHDmvspaGTRVRTRT-IRQFPIGSEKECPEFE-EKEPC 412
Cdd:smart00209    1 WSEWSEWSPCSVTCGG-----GVQTRTRScCSPPPQNGGGPCTGEDvETRAC 47
 
Name Accession Description Interval E-value
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 195-246 3.18e-17

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 76.93  E-value: 3.18e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578813337   195 CIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPC 246
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1287-1340 2.13e-15

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 71.54  E-value: 2.13e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 578813337  1287 CQLSDWSPWSECSQTCGlTGKMIRRRTVTQPFQGDGRPCPSLMdQSKPCPVKPC 1340
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-GGVQTRTRTVIVEPQNGGRPCPELL-ERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 361-412 2.20e-12

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 63.07  E-value: 2.20e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578813337   361 CQVSEWSEWSPCSKTCHDmvspaGTRVRTRTIRQFPIGSEKECPEFEEKEPC 412
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGG-----GVQTRTRTVIVEPQNGGRPCPELLERRPC 47
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1036-1076 3.20e-11

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 59.60  E-value: 3.20e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 578813337  1036 CKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKL 1076
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL 41
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 772-828 1.55e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 52.28  E-value: 1.55e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 578813337   772 CIVTPYSDWTSCPSSCKEGdssirKQSRHRVIIQLPANGGRDCTdPLYEEKACEAPQ 828
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGG-----VQTRTRTVIVEPQNGGRPCP-ELLERRPCNLPP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 197-247 2.87e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 2.87e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578813337    197 VSEFSAWSECSKTCGSGLQHRTRHVV-APPQFGGSGCP-NLTEFQVCQSSPCE 247
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCsPPPQNGGGPCTgEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1290-1340 1.09e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.89  E-value: 1.09e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 578813337   1290 SDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC 1340
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1415-1474 1.48e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 49.59  E-value: 1.48e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813337  1415 CYLKDWSSWSLCQLTCvngedlgFGGIQVRSRPVIIQELENQHLCPEQmLETKSCYDGQC 1474
Cdd:pfam19028    1 CVVSEWSEWSECSVTC-------GGGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
1290-1340 2.47e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 48.57  E-value: 2.47e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578813337  1290 SDWSPWSECSQTCGLtGKMIRRRTVTQPFQGdGRPCPSLMDQSKPCPVKPC 1340
Cdd:pfam00090    1 SPWSPWSPCSVTCGK-GIQVRQRTCKSPFPG-GEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1166-1217 3.20e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 48.43  E-value: 3.20e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578813337  1166 CVISEWGPWTQCVLPCNqSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNK 1217
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
TSP_1 pfam00090
Thrombospondin type 1 domain;
198-246 1.54e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.64  E-value: 1.54e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578813337   198 SEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPC 246
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIETQACKMDKC 49
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1099-1161 9.69e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.37  E-value: 9.69e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578813337  1099 WVTEPWSICKVTfvnmrenCGEGVQTRKVRCMQntADGPSEhVEDYLCDPEEMPLGSRVCKLP 1161
Cdd:pfam19030    1 WVAGPWGECSVT-------CGGGVQTRLVQCVQ--KGGGSI-VPDSECSAQKKPPETQSCNLK 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 699-767 2.94e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 2.94e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813337   699 WQTGPWGQCiedtsvssfnttttwngEASCSVGMQTRKVICVRVNVGQ-VGPKKCPESLRPETVRPCLLP 767
Cdd:pfam19030    1 WVAGPWGEC-----------------SVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLK 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 513-573 4.33e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 42.27  E-value: 4.33e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578813337   513 CEVSPWSAWGPCTYEnCNdqqgkKGFKLRKRRITNEPTGGSgvtGNCPHLLEAIPCEEPAC 573
Cdd:pfam19028    1 CVVSEWSEWSECSVT-CG-----GGVQTRTRTVIVEPQNGG---RPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1039-1077 1.30e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 1.30e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 578813337   1039 SEWSNWSRCSKSCGSGVKVRSKW-LREKPYNGGRPCPKLD 1077
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRScCSPPPQNGGGPCTGED 41
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 363-412 1.68e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 1.68e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 578813337    363 VSEWSEWSPCSKTCHDmvspaGTRVRTRT-IRQFPIGSEKECPEFE-EKEPC 412
Cdd:smart00209    1 WSEWSEWSPCSVTCGG-----GVQTRTRScCSPPPQNGGGPCTGEDvETRAC 47
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 203-246 1.71e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.20  E-value: 1.71e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 578813337   203 WSECSKTCGSGLQHRT---RHVVAPPQFGGSGCPNL---TEFQVCQSSPC 246
Cdd:pfam19030    6 WGECSVTCGGGVQTRLvqcVQKGGGSIVPDSECSAQkkpPETQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
364-412 2.25e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.40  E-value: 2.25e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578813337   364 SEWSEWSPCSKTCHDmvspaGTRVRTRTIRQFPIGSEKECPEFEEKEPC 412
Cdd:pfam00090    1 SPWSPWSPCSVTCGK-----GIQVRQRTCKSPFPGGEPCTGDDIETQAC 44
TSP_1 pfam00090
Thrombospondin type 1 domain;
1039-1090 3.09e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.01  E-value: 3.09e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578813337  1039 SEWSNWSRCSKSCGSGVKVRSKwLREKPYNGGRPCPklDHVNQAQVYEVVPC 1090
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQR-TCKSPFPGGEPCT--GDDIETQACKMDKC 49
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 200-246 4.25e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 36.54  E-value: 4.25e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 578813337   200 FSAWSECSKTCGSGLQHRTRHvvappqfGGSGCPNLTEFQVCQSSPC 246
Cdd:pfam19035    5 STEWSPCSKTCGMGVSTRVSN-------DNAECKLVTETRLCQLRPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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