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Conserved domains on  [gi|767948526|ref|XP_006716156|]
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N-acetylneuraminate 9-O-acetyltransferase isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cas1_AcylT super family cl24198
10 TM Acyl Transferase domain found in Cas1p; Cas1p protein of Cryptococcus neoformans is ...
 295-455 1.25e-79

10 TM Acyl Transferase domain found in Cas1p; Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase superfamily. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family. The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity.


The actual alignment was detected with superfamily member pfam07779:

Pssm-ID: 462263  Cd Length: 483  Bit Score: 255.31  E-value: 1.25e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948526  295 LKPVDGSCCQPRPPVTLIQKLAACFFT---LSIIGYLIFYIIHRNAHRKNKPCTDLESGEEKKNiinTPVSSLEILLQSF 371
Cdd:pfam07779   1 MNPNDGTCCSSPEPYTTLQILTAAVFGicaLAVIILLVRYLLKRRGRPRHSPVPDIESAEEKTP---ATPPDLYTLMTAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948526  372 CKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGAS 451
Cdd:pfam07779  78 AKLGLIMAYFYLCDRTNFFMKENKYYTHSSFWLPIGYILVLGLFFTEDSKETKVLNRDQTDEWKGWMQLVILIYHITGAS 157


                  ....
gi 767948526  452 TIVG 455
Cdd:pfam07779 158 KVLP 161
 
Name Accession Description Interval E-value
Cas1_AcylT pfam07779
10 TM Acyl Transferase domain found in Cas1p; Cas1p protein of Cryptococcus neoformans is ...
 295-455 1.25e-79

10 TM Acyl Transferase domain found in Cas1p; Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase superfamily. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family. The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity.


Pssm-ID: 462263  Cd Length: 483  Bit Score: 255.31  E-value: 1.25e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948526  295 LKPVDGSCCQPRPPVTLIQKLAACFFT---LSIIGYLIFYIIHRNAHRKNKPCTDLESGEEKKNiinTPVSSLEILLQSF 371
Cdd:pfam07779   1 MNPNDGTCCSSPEPYTTLQILTAAVFGicaLAVIILLVRYLLKRRGRPRHSPVPDIESAEEKTP---ATPPDLYTLMTAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948526  372 CKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGAS 451
Cdd:pfam07779  78 AKLGLIMAYFYLCDRTNFFMKENKYYTHSSFWLPIGYILVLGLFFTEDSKETKVLNRDQTDEWKGWMQLVILIYHITGAS 157


                  ....
gi 767948526  452 TIVG 455
Cdd:pfam07779 158 KVLP 161
 
Name Accession Description Interval E-value
Cas1_AcylT pfam07779
10 TM Acyl Transferase domain found in Cas1p; Cas1p protein of Cryptococcus neoformans is ...
 295-455 1.25e-79

10 TM Acyl Transferase domain found in Cas1p; Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase superfamily. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family. The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity.


Pssm-ID: 462263  Cd Length: 483  Bit Score: 255.31  E-value: 1.25e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948526  295 LKPVDGSCCQPRPPVTLIQKLAACFFT---LSIIGYLIFYIIHRNAHRKNKPCTDLESGEEKKNiinTPVSSLEILLQSF 371
Cdd:pfam07779   1 MNPNDGTCCSSPEPYTTLQILTAAVFGicaLAVIILLVRYLLKRRGRPRHSPVPDIESAEEKTP---ATPPDLYTLMTAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948526  372 CKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGAS 451
Cdd:pfam07779  78 AKLGLIMAYFYLCDRTNFFMKENKYYTHSSFWLPIGYILVLGLFFTEDSKETKVLNRDQTDEWKGWMQLVILIYHITGAS 157


                  ....
gi 767948526  452 TIVG 455
Cdd:pfam07779 158 KVLP 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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