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Conserved domains on  [gi|578814730|ref|XP_006716234|]
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plexin-A4 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
39-511 0e+00

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 1051.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   39 SFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11274     1 FITFTGDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLTLTNNINKML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11274    81 LIDYKENRLIACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11274   161 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMISPPGSTTKEQVYTS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11274   241 KLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSLGVGPDDDILFTVFSKGQKRKMKSLDESALCIF 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11274   321 VLKEINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSEMVRGLPVFTEDRDRMTSVIAY 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578814730  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511
Cdd:cd11274   401 VYKNHSLAFVGTKSGKLKKIRVDGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTRVPVESCG 473
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
1311-1859 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


:

Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 968.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPG---YRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVA 1387
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVtndGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1388 SLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQ 1467
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVESKN-PKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQ 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1468 QMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLVLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPK 1547
Cdd:pfam08337  160 QVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQRPS 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1548 AADMDLEWRQGSGARMILQDEDITTKIENDWKRLNTLAHYQVPDGSVVALVSkqvtaynavnnstvsrtsaskyenmiry 1627
Cdd:pfam08337  240 IDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP---------------------------- 291
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1628 tgspdslrsrtpmitpdlesgvKMWHLVKNHEHGDQKEG-DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrg 1706
Cdd:pfam08337  292 ----------------------KYWHLVKPSDEGDQRKKsERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPN-- 347
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1707 SALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSE 1786
Cdd:pfam08337  348 SALPLAVKYLFDFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSE 427
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578814730  1787 HRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGK 1859
Cdd:pfam08337  428 HRLGKDSPSNKLLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
1040-1140 3.88e-47

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238586  Cd Length: 99  Bit Score: 164.13  E-value: 3.88e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINiCEVLNATEMTCQAPALALGPDHQsDLTERPEEFG 1119
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTS-CKVRNSTLMTCPAPSLALLNRSP-EPGERPVEFG 78
                          90       100
                  ....*....|....*....|.
gi 578814730 1120 FILDNVQSLLILNKTNFTYYP 1140
Cdd:cd01181    79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
708-802 1.00e-39

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


:

Pssm-ID: 465619  Cd Length: 94  Bit Score: 142.80  E-value: 1.00e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   708 DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMeINNLPVELTVVWNG 787
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGS-SGELPATFYVTWNG 79
                           90
                   ....*....|....*
gi 578814730   788 HFNIDNPAQNKVHLY 802
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
955-1038 6.20e-35

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238584  Cd Length: 85  Bit Score: 128.50  E-value: 6.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVF 1034
Cdd:cd01179     2 SITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDGARRLAPLVF 81

                  ....
gi 578814730 1035 QYVE 1038
Cdd:cd01179    82 TYTE 85
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
858-953 3.87e-27

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 106.63  E-value: 3.87e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVC 937
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNGPVEVTVGHG 80
                          90
                  ....*....|....*.
gi 578814730  938 rpEFMARSSQLYYFMT 953
Cdd:cd01180    81 --SFRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
564-654 4.23e-24

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 97.73  E-value: 4.23e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   564 HPNNISVSQY-NVLLVLEtyNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIiTENGDHHVVQLQLKSKET 642
Cdd:pfam17960    1 TPDNISRTTAtQLTLTVP--NLPALSEGYSCVFGDLTESPATVHDNGVKCATPPPSQLPPI-PTGQDHVTVKLSLRSSET 77
                           90
                   ....*....|..
gi 578814730   643 GMTFASTSFVFY 654
Cdd:pfam17960   78 GVDFASTNFTFY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-548 2.53e-14

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 68.73  E-value: 2.53e-14
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578814730    510 CGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEP 548
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
804-856 8.96e-09

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 53.10  E-value: 8.96e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 578814730   804 CGAMReSCGLCLKADpDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCT 856
Cdd:pfam01437    2 CSQYT-SCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKCP 52
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
655-702 2.82e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.55  E-value: 2.82e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 578814730   655 NCSVHNSCLSCVESP-YRCHWCKYRHVCTHdPKTCSFQEGR----VKLPEDCP 702
Cdd:pfam01437    1 RCSQYTSCSSCLAARdPYCGWCSSEGRCVR-RSACGAPEGNceewEQASSKCP 52
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
1142-1222 5.11e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.38  E-value: 5.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1142 PVFEAFGPS-GILElkPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTVT-VSDVQLLCESP--NLIGRHKVMARVG 1217
Cdd:cd00603     1 PVITSISPSsGPLS--GGTRLTITGSNL------GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPaaATPGEGPVEVTVD 72

                  ....*
gi 578814730 1218 GMEYS 1222
Cdd:cd00603    73 GANVS 77
 
Name Accession Description Interval E-value
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
39-511 0e+00

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 1051.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   39 SFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11274     1 FITFTGDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLTLTNNINKML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11274    81 LIDYKENRLIACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11274   161 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMISPPGSTTKEQVYTS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11274   241 KLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSLGVGPDDDILFTVFSKGQKRKMKSLDESALCIF 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11274   321 VLKEINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSEMVRGLPVFTEDRDRMTSVIAY 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578814730  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511
Cdd:cd11274   401 VYKNHSLAFVGTKSGKLKKIRVDGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTRVPVESCG 473
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
1311-1859 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 968.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPG---YRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVA 1387
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVtndGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1388 SLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQ 1467
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVESKN-PKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQ 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1468 QMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLVLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPK 1547
Cdd:pfam08337  160 QVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQRPS 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1548 AADMDLEWRQGSGARMILQDEDITTKIENDWKRLNTLAHYQVPDGSVVALVSkqvtaynavnnstvsrtsaskyenmiry 1627
Cdd:pfam08337  240 IDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP---------------------------- 291
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1628 tgspdslrsrtpmitpdlesgvKMWHLVKNHEHGDQKEG-DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrg 1706
Cdd:pfam08337  292 ----------------------KYWHLVKPSDEGDQRKKsERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPN-- 347
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1707 SALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSE 1786
Cdd:pfam08337  348 SALPLAVKYLFDFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSE 427
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578814730  1787 HRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGK 1859
Cdd:pfam08337  428 HRLGKDSPSNKLLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
1311-1888 0e+00

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 785.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVASLI 1390
Cdd:cd12790     1 GIPFLDYRTYAMRVLFPGIEDHPVLRELEVERDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1391 MTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQME 1470
Cdd:cd12790    81 MVVLQSKMEYATDILKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1471 KGPIdaitgearyslsedklirqqidyktlvlscvspdnanspevpvkilncdtitqvkekilDAIfknvpcshrpkaad 1550
Cdd:cd12790   161 KGPI-----------------------------------------------------------DAI-------------- 167
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1551 mdlewrqgsgarmilqdedittkiendwkrlntlahyqvpdgsvvalvskqvtaynavnnstvsrtsaskyenmirytgs 1630
Cdd:cd12790       --------------------------------------------------------------------------------
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1631 pdslrsrtpmitpdlesgvkmwhlvknhehgdqkegdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALP 1710
Cdd:cd12790   168 ----------------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALP 207
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1711 LAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLG 1790
Cdd:cd12790   208 LAIKYMFDFLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLG 287
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1791 KDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPLDH 1870
Cdd:cd12790   288 KDSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEE 367
                         570
                  ....*....|....*...
gi 578814730 1871 DDQCGKQKLAYKLEQVIT 1888
Cdd:cd12790   368 DEFARKQRLAYKLEQVIN 385
Sema smart00630
semaphorin domain;
51-482 6.33e-76

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 258.07  E-value: 6.33e-76
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730     51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRivqtCNEPLTTTNNVNK-MLLIDYKENRLIA 129
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECV----SKGKDPPTDCVNYiRLLLDYNEDRLLV 76
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    130 CGS-LYQGICKLLRLEDLFklgepyhkkehylsgvnesgsvfgvivsysnlddklfIATAVD--GKPEYFPTISSRKLTK 206
Cdd:smart00630   77 CGTnAFQPVCRLRNLGELY-------------------------------------VGTVADfsGSDPAIPRSLSVRRLK 119
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    207 NSeadgmfaYVFHDEFVASMIKIPSDtftiipdfdIYYVYGFSSGNFVYFLTLQPEMVsppgSTTKEQVYTSKLVRLCKE 286
Cdd:smart00630  120 GT-------SGVSLRTVLYDSKWLNE---------PNFVYAFESGDFVYFFFRETAVE----DDNCGKAVHSRVARVCKN 179
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    287 DTA--------FNSYVEVPIGC---ERSGVEYRLLQAAYLSKAGAvlgrtlgvhPDDDLLFTVFSKGQkrkmKSLDESAL 355
Cdd:smart00630  180 DVGgprsldkkWTSFLKARLECsvpGEDPFYFNELQAAFLLPPGS---------ESDDVLYGVFSTSS----NPIPGSAV 246
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    356 CIFILKQINDRIKERLQSCYRGEGTLDL----AWLKVKDIPC-----SSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFT 426
Cdd:smart00630  247 CAFSLSDINAVFNGPFKECETSTSQWLPysrgKVPYPRPGTCpnkppSSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFV 326
                           410       420       430       440       450       460
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578814730    427 E--DRDRMTSVIAYV---YKNHSLAFVGTKSGKLKKIRVDGPRGN--ALQYETVQVVDPG-PVL 482
Cdd:smart00630  327 KtdSNYLLTSIAVDRvatDGNYTVLFLGTSDGRILKVVLSESSSSseSVVLEEISVFPDGsPIS 390
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
1040-1140 3.88e-47

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 164.13  E-value: 3.88e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINiCEVLNATEMTCQAPALALGPDHQsDLTERPEEFG 1119
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTS-CKVRNSTLMTCPAPSLALLNRSP-EPGERPVEFG 78
                          90       100
                  ....*....|....*....|.
gi 578814730 1120 FILDNVQSLLILNKTNFTYYP 1140
Cdd:cd01181    79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
708-802 1.00e-39

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 142.80  E-value: 1.00e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   708 DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMeINNLPVELTVVWNG 787
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGS-SGELPATFYVTWNG 79
                           90
                   ....*....|....*
gi 578814730   788 HFNIDNPAQNKVHLY 802
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
955-1038 6.20e-35

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 128.50  E-value: 6.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVF 1034
Cdd:cd01179     2 SITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDGARRLAPLVF 81

                  ....
gi 578814730 1035 QYVE 1038
Cdd:cd01179    82 TYTE 85
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
310-488 3.79e-31

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 121.61  E-value: 3.79e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   310 LQAAYLSKAGAVLGRtlgvhpdDDLLFTVFSKGQKrkmKSLDESALCIFILKQINDRIKERlqscYRGEGTLDLAWLKV- 388
Cdd:pfam01403    1 LQDVFVLKPGAGDAL-------DTVLYGVFTTQWS---NSIGGSAVCAFSLSDINAVFEGP----FKEQEKSDSKWLPYt 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   389 ------KDIPC--SSALLTIDDNFCGLDMNAPLGVS--DMVRGIPVFTEDRDRMTSVIAY----VYKNHSLAFVGTKSGK 454
Cdd:pfam01403   67 gkvpypRPGTCinDPLRLDLPDSVLNFVKDHPLMDEavQPVGGRPLLVRTGVRLTSIAVDrvqaLDGNYTVLFLGTDDGR 146
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 578814730   455 LKKIrVDGPRGNALQYETVQVVDPG-PVLRDMAFS 488
Cdd:pfam01403  147 LHKV-VLVGSEESHIIEEIQVFPEPqPVLNLLLSS 180
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
858-953 3.87e-27

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 106.63  E-value: 3.87e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVC 937
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNGPVEVTVGHG 80
                          90
                  ....*....|....*.
gi 578814730  938 rpEFMARSSQLYYFMT 953
Cdd:cd01180    81 --SFRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
564-654 4.23e-24

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 97.73  E-value: 4.23e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   564 HPNNISVSQY-NVLLVLEtyNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIiTENGDHHVVQLQLKSKET 642
Cdd:pfam17960    1 TPDNISRTTAtQLTLTVP--NLPALSEGYSCVFGDLTESPATVHDNGVKCATPPPSQLPPI-PTGQDHVTVKLSLRSSET 77
                           90
                   ....*....|..
gi 578814730   643 GMTFASTSFVFY 654
Cdd:pfam17960   78 GVDFASTNFTFY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-548 2.53e-14

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 68.73  E-value: 2.53e-14
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578814730    510 CGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEP 548
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
IPT smart00429
ig-like, plexins, transcription factors;
1039-1139 6.92e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 68.99  E-value: 6.92e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   1039 DPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEhiniCEVLN--ATEMTCQAPalalgPDHQSDLTERPE 1116
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP----CTFSPssSTAIVCKTP-----PYHNIPGSVPVR 71
                            90       100
                    ....*....|....*....|...
gi 578814730   1117 EFGFILDNVQSLlilnKTNFTYY 1139
Cdd:smart00429   72 TVGLRNGGVPSS----PQPFTYV 90
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
509-551 1.47e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 66.58  E-value: 1.47e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 578814730   509 SCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRF 551
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEGNCEE 43
IPT smart00429
ig-like, plexins, transcription factors;
857-950 1.65e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 67.83  E-value: 1.65e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    857 NPRITEIIPVTGPREGGTKVTIRGENLGlEFRDIASHVKVAGVECSPLVDGyipAEQIVCEMGEAKPSQHAGFVEiCVAV 936
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVR-TVGL 75
                            90
                    ....*....|....
gi 578814730    937 CRPEFMARSSQLYY 950
Cdd:smart00429   76 RNGGVPSSPQPFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
954-1036 6.95e-13

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 65.93  E-value: 6.95e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGS-NVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLeMKVSVQV-DRAKIHQD 1031
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGL-VNVSVTVgGGGISSSP 79

                   ....*
gi 578814730  1032 LVFQY 1036
Cdd:pfam01833   80 LTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
954-1037 6.24e-12

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 63.21  E-value: 6.24e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMF--GKQPCLFHRRSPSYIVCNTTS-SDEVLEMKVS-VQVDRAKIH 1029
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPyHNIPGSVPVRtVGLRNGGVP 81

                    ....*....
gi 578814730   1030 -QDLVFQYV 1037
Cdd:smart00429   82 sSPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
858-937 4.43e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.54  E-value: 4.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIasHVKVAGVECSPLvdgYIPAEQIVCEMgeakPSQHAGFVEICVAVC 937
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVI---SVSSTTIVCTT----PPGTSGLVNVSVTVG 71
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
804-856 8.96e-09

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 53.10  E-value: 8.96e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 578814730   804 CGAMReSCGLCLKADpDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCT 856
Cdd:pfam01437    2 CSQYT-SCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKCP 52
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
655-702 2.82e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.55  E-value: 2.82e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 578814730   655 NCSVHNSCLSCVESP-YRCHWCKYRHVCTHdPKTCSFQEGR----VKLPEDCP 702
Cdd:pfam01437    1 RCSQYTSCSSCLAARdPYCGWCSSEGRCVR-RSACGAPEGNceewEQASSKCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
655-702 3.23e-07

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 48.70  E-value: 3.23e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 578814730    655 NCSVHNSCLSCVESPY-RCHWCKYRHVCTHDPkTCSFQEGRVkLPEDCP 702
Cdd:smart00423    1 RCSKYTSCSECLLARDpYCAWCSSQGRCTSGE-RCDSRRQNW-LSGGCP 47
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
1142-1222 5.11e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.38  E-value: 5.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1142 PVFEAFGPS-GILElkPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTVT-VSDVQLLCESP--NLIGRHKVMARVG 1217
Cdd:cd00603     1 PVITSISPSsGPLS--GGTRLTITGSNL------GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPaaATPGEGPVEVTVD 72

                  ....*
gi 578814730 1218 GMEYS 1222
Cdd:cd00603    73 GANVS 77
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
806-849 6.73e-07

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 47.54  E-value: 6.73e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 578814730    806 AMRESCGLCLKAdPDFACGWCQGPGQCTLRQHCPAQESQWLELS 849
Cdd:smart00423    3 SKYTSCSECLLA-RDPYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
1142-1226 1.32e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.13  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1142 PVFEAFGPSGIlELKPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTV-TVSDVQLLCESPNL-IGRHKVMARVGGM 1219
Cdd:pfam01833    1 PVITSISPSSG-PASGGTTITITGSNF------GTDSSDLKVTIGGTPCTViSVSSTTIVCTTPPGtSGLVNVSVTVGGG 73

                   ....*..
gi 578814730  1220 EYSPGMV 1226
Cdd:pfam01833   74 GISSSPL 80
IPT smart00429
ig-like, plexins, transcription factors;
1141-1204 1.70e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.02  E-value: 1.70e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578814730   1141 NPVFEAFGP-SGILElkPGTPIILKGKNLIPpvaGGNVKlnYTVLVGEKPCTVT-VSDVQLLCESP 1204
Cdd:smart00429    1 DPVITRISPtSGPVS--GGTEITLCGKNLKS---ISVVF--VEVGVGEAPCTFSpSSSTAIVCKTP 59
 
Name Accession Description Interval E-value
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
39-511 0e+00

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 1051.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   39 SFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11274     1 FITFTGDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLTLTNNINKML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11274    81 LIDYKENRLIACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11274   161 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMISPPGSTTKEQVYTS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11274   241 KLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSLGVGPDDDILFTVFSKGQKRKMKSLDESALCIF 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11274   321 VLKEINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSEMVRGLPVFTEDRDRMTSVIAY 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578814730  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511
Cdd:cd11274   401 VYKNHSLAFVGTKSGKLKKIRVDGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTRVPVESCG 473
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
1311-1859 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 968.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPG---YRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVA 1387
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVtndGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1388 SLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQ 1467
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVESKN-PKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQ 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1468 QMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLVLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPK 1547
Cdd:pfam08337  160 QVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQRPS 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1548 AADMDLEWRQGSGARMILQDEDITTKIENDWKRLNTLAHYQVPDGSVVALVSkqvtaynavnnstvsrtsaskyenmiry 1627
Cdd:pfam08337  240 IDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP---------------------------- 291
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1628 tgspdslrsrtpmitpdlesgvKMWHLVKNHEHGDQKEG-DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrg 1706
Cdd:pfam08337  292 ----------------------KYWHLVKPSDEGDQRKKsERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPN-- 347
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1707 SALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSE 1786
Cdd:pfam08337  348 SALPLAVKYLFDFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSE 427
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578814730  1787 HRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGK 1859
Cdd:pfam08337  428 HRLGKDSPSNKLLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
Sema_plexin_A cd11244
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ...
40-508 0e+00

The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200505 [Multi-domain]  Cd Length: 470  Bit Score: 930.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   40 FVTFRGEP-AEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11244     1 FVTFRGEPrDWSFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPLTTTNNVNKLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11244    81 LIDYSENRLIACGSLYQGVCKLLRLEDLFKLGEPHHKKEHYLSGVNESGTMFGVIVSYSNGDDKLFIGTAVDGKSEYFPT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11244   161 LSSRKLTADEESDGMFAYVYHDEFVSSQIKIPSDTLSIIPDFDIYYVYGFSSGNFVYFLTLQPETQLTPGDSTGEQFYTS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11244   241 KIVRLCKDDTKFYSYVEFPIGCTRDGVEYRLLQAAYLSKPGKALAQALGISEDEDVLFTIFSKGQKNRMKPPDESALCLF 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11244   321 TLKQINLRIKERLQSCYRGEGKLSLPWLLNKDLPCINAPLQIDDNFCGLDMNQPLGGSDMVEGIPLFTDDRDRMTSVAAY 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11244   401 VYKGHSVVFVGTKSGKLKKIRVDGPPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIMSERQVTRVPVE 470
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
1311-1888 0e+00

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 785.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVASLI 1390
Cdd:cd12790     1 GIPFLDYRTYAMRVLFPGIEDHPVLRELEVERDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1391 MTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQME 1470
Cdd:cd12790    81 MVVLQSKMEYATDILKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1471 KGPIdaitgearyslsedklirqqidyktlvlscvspdnanspevpvkilncdtitqvkekilDAIfknvpcshrpkaad 1550
Cdd:cd12790   161 KGPI-----------------------------------------------------------DAI-------------- 167
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1551 mdlewrqgsgarmilqdedittkiendwkrlntlahyqvpdgsvvalvskqvtaynavnnstvsrtsaskyenmirytgs 1630
Cdd:cd12790       --------------------------------------------------------------------------------
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1631 pdslrsrtpmitpdlesgvkmwhlvknhehgdqkegdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALP 1710
Cdd:cd12790   168 ----------------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALP 207
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1711 LAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLG 1790
Cdd:cd12790   208 LAIKYMFDFLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLG 287
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1791 KDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPLDH 1870
Cdd:cd12790   288 KDSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEE 367
                         570
                  ....*....|....*...
gi 578814730 1871 DDQCGKQKLAYKLEQVIT 1888
Cdd:cd12790   368 DEFARKQRLAYKLEQVIN 385
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
40-551 0e+00

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 774.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   40 FVTFRGEPAE-GFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11272     1 FNTFHSENRDwTFNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11272    81 IIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEmvSPPG---STTKEQV 275
Cdd:cd11272   161 LSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGNFVYFLTVQPE--TPEGvsiNSAGDLF 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  276 YTSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESAL 355
Cdd:cd11272   239 YTSRIVRLCKDDPKFHSYVSLPFGCVRGGVEYRLLQAAYLSKPGEVLARSLNITAQEDVLFAIFSKGQKQYHHPPDDSAL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  356 CIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSV 435
Cdd:cd11272   319 CAFPIRAINAQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGVTLYTSSRDRLTSV 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  436 IAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVV-DPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYQ 514
Cdd:cd11272   399 ASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVFkDGSPILRDMAFSIDHKYLYVMSERQVSRVPVESCEQYT 478
                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 578814730  515 SCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRF 551
Cdd:cd11272   479 TCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEPFRF 515
Sema_plexin_A1 cd11271
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ...
37-508 0e+00

The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200532 [Multi-domain]  Cd Length: 474  Bit Score: 624.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   37 QRSFVTFRGePAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNK 116
Cdd:cd11271     1 QPPFRTFTA-SDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGLGTTNNVNK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  117 MLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYF 196
Cdd:cd11271    80 LLLVDYAANRLIACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVNESGTMSGVIIEVGNGQNKLFVGTPIDGKSEYF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  197 PTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQ--PEMVSPpgSTTKEQ 274
Cdd:cd11271   160 PTLSSRKLMANEENAEMFGFVYQDEFVSSQLKIPSDTLSKFPTFDIYYVYSFSSEQFVYYLTLQldTQLTSP--DSTGEQ 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  275 VYTSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESA 354
Cdd:cd11271   238 FFTSKIVRLCVDDPKFYSYVEFPIGCEQDGVEYRLIQDAYLSKPGKALAKQLGISEREDILFTVFSQGQKNRVKPPKESV 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  355 LCIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTS 434
Cdd:cd11271   318 LCLFTLKKIKDKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDNFCGQDFNQPLGGTVTIEGTPLFVDKEDGMTS 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578814730  435 VIAYVYKNHSLAFVGTKSGKLKKIRVD--GPRGN-ALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11271   398 VAAYDYRGRTVVFAGTRSGRIKKILVDlsAPSSRpALQYENVVAHEGSPILRDLVLSPDRQYIYAMTEKQVTRVPVE 474
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
53-508 0e+00

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 616.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   53 HLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYKENRLIACGS 132
Cdd:cd11273    15 HLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCAHRLAPVDNVNKLLLVDYAGNRLVACGS 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  133 LYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKLTKNSEADG 212
Cdd:cd11273    95 IWQGVCQFLRLEDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGKGPSKLFVGTAIDGKSEYFPTLSSRKLISDEDSAD 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  213 MFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNS 292
Cdd:cd11273   175 MFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYVYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCANDTEFYS 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  293 YVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDRIKERLQ 372
Cdd:cd11273   255 YVEFPLGCSKDGVEYRLVQAAHLAKPGLLLAQALGVPEDEDVLFTIFSQGQKNRASPPRETILCLFTLSNINAHIRERIQ 334
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  373 SCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKS 452
Cdd:cd11273   335 SCYRGEGTLSLPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRS 414
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578814730  453 GKLKKIRVDGPRgNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11273   415 GSLKKVRVDGFQ-DAHLYETVPVVDGSPILRDMVFSPDHRYIYLLSEKQVSQLPVE 469
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
1311-1887 0e+00

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 564.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVASLI 1390
Cdd:cd12205     1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHGSRRPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVASLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1391 MTVLQSKLEYATDVLKQLLADLIDKNLeSKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQME 1470
Cdd:cd12205    81 MVALQGKMEYATEILFDLLTDLIEKSV-SKKHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQQIE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1471 KGPIdaitgearyslsedklirqqidyktlvlscvspdnanspevpvkilncdtitqvkekilDAIfknvpcshrpkaad 1550
Cdd:cd12205   160 KGPV-----------------------------------------------------------DAI-------------- 166
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1551 mdlewrqgsgarmilqdedittkiendwkrlntlahyqvpdgsvvalvskqvtaynavnnstvsrtsaskyenmirytgs 1630
Cdd:cd12205       --------------------------------------------------------------------------------
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1631 pdslrsrtpmitpdlesgvkmwhlvknhehgdqkegdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRgsALP 1710
Cdd:cd12205   167 ----------------------------------------KLIPEIFLTRLLSTKGTLQKFVDDLFESILSVPQR--SLP 204
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1711 LAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLG 1790
Cdd:cd12205   205 PAIKYLFDFLDEQARKHGISDPDVLHAWKTNSLPLRFWVNIIKNPDFVFDVNKTPTVDSCLSVIAQTFMDACSTSEHKLG 284
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1791 KDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPLDH 1870
Cdd:cd12205   285 KDSPSNKLLFAKDIPRYREMVANFYRDISNLPPVSDEEMNSYLAELSESHSGEFNTNVALSELYIYAVKYGDQLLEALED 364
                         570
                  ....*....|....*..
gi 578814730 1871 DDQCGKQKLAYKLEQVI 1887
Cdd:cd12205   365 DREARVQQLADKLSQVA 381
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
1311-1890 4.41e-140

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 440.52  E-value: 4.41e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYRQER--VEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVAS 1388
Cdd:cd12787     1 GIPFLDYKTYAERVFFPGHKDGPLDVMIKLDIPEPRRptVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYVAS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1389 LIMTVLQSKLEYATDVLKQLLADLIDKNLeSKNhPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQ 1468
Cdd:cd12787    81 LLTVALHGKLEYYTDIMRTLLLDLLAQYV-VKN-PKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAIKHQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1469 MEKGPIDAITGearyslsedklirqqidyktlvlscvspdnanspevpvkilncdtitqvkekildaifknvpcshrpka 1548
Cdd:cd12787   159 VDKGPVDAVTG--------------------------------------------------------------------- 169
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1549 admdlewrqgsgarmilqdedittkiendwKRlntlahyqvpdgsvvalvskqvtaynavnnstvsrtsaskyenmiryt 1628
Cdd:cd12787   170 ------------------------------KR------------------------------------------------ 171
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1629 gspdslrsrtpmitpdlesgvkmwhlvknhehgdqkegdrgSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsA 1708
Cdd:cd12787   172 -----------------------------------------AKAIPEIYLTRLLSMKGTLQKFVDDFFQSILSPGR---P 207
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1709 LPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHR 1788
Cdd:cd12787   208 VPPAVKYFFDLLDEQAEKHGIQDEDTIHIWKTNSLPLRFWVNILKNPQFIFDVHVSDNVDASLSVIAQTFMDACTRTEHK 287
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1789 LGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPL 1868
Cdd:cd12787   288 LGRDSPSNKLLYAREIPRYKKMVERYYADIRQMVPASDQEMNSHLAELSRNYTDSLNTLVALHELYQYIQKYYDQIINAL 367
                         570       580
                  ....*....|....*....|..
gi 578814730 1869 DHDDQCGKQKLAYKLEQVITLM 1890
Cdd:cd12787   368 EEDPAAQKMQLAFRLQQIAAAV 389
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
1311-1890 1.14e-136

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 431.57  E-value: 1.14e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGY--RQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVAS 1388
Cdd:cd12791     1 GIPFLDYRTYAERVFFPGHGGCPLQPSLEGDGEegRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1389 LIMTVLQSKLEYATDVLKQLLADLIDKNLeSKNhPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQ 1468
Cdd:cd12791    81 LLSLALHGKLEYLTDIMKTLLGDLAAHYV-HKN-PKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1469 MEKGPIDAITGEaryslsedklirqqidyktlvlscvspdnanspevpvkilncdtitqvkekildaifknvpcshrpka 1548
Cdd:cd12791   159 VDKGPVDAVTGK-------------------------------------------------------------------- 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1549 admdlewrqgsgarmilqdedittkiendwkrlntlahyqvpdgsvvalvskqvtaynavnnstvsrtsaskyenmiryt 1628
Cdd:cd12791       --------------------------------------------------------------------------------
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1629 gspdslRSRtpmitpdlesgvkmwhlvknhehgdqkegdrgSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTahrGSA 1708
Cdd:cd12791   171 ------RER--------------------------------AKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSV---NRP 209
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1709 LPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHR 1788
Cdd:cd12791   210 VPIAVKYLFDFLDELAEKHGIEDPETLHIWKTNSLLLRFWVNTLKNPQFIFDVRVSDNVDAILAVIAQTFIDSCTISEHK 289
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1789 LGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPL 1868
Cdd:cd12791   290 VGRDSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALTELSGNYTSAPHCLVALQELYNHIHRYYDQIISAL 369
                         570       580
                  ....*....|....*....|..
gi 578814730 1869 DHDDQCGKQKLAYKLEQVITLM 1890
Cdd:cd12791   370 EEDPVGQKMQLACRLQQIAALV 391
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
1311-1886 1.77e-135

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 427.91  E-value: 1.77e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVASLI 1390
Cdd:cd12793     1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1391 MTVLQSKLEYATDVLKQLLADLIDKNLeSKNhPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQME 1470
Cdd:cd12793    81 TVALHGKLEYFTDILKTLLNDLVEQYV-AKN-PKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1471 KGPIDAITGEARyslsedklirqqidyktlvlscvspdnanspevpvkilncdtitqvkekildaifknvpcshrpkaad 1550
Cdd:cd12793   159 KGPVDAVTGKER-------------------------------------------------------------------- 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1551 mdlewrqgsgarmilqdedittkiendwkrlntlahyqvpdgsvvalvskqvtaynavnnstvsrtsaskyenmirytgs 1630
Cdd:cd12793       --------------------------------------------------------------------------------
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1631 pdslrsrtpmitpdlesgvkmwhlvknhehgdqkegdrgSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsALP 1710
Cdd:cd12793   171 ---------------------------------------AKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSR---PVP 208
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1711 LAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLG 1790
Cdd:cd12793   209 LAVKYFFDLLDEQALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLG 288
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1791 KDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPLDH 1870
Cdd:cd12793   289 RDSPINKLLYARDIPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEE 368
                         570
                  ....*....|....*.
gi 578814730 1871 DDQCGKQKLAYKLEQV 1886
Cdd:cd12793   369 DSTAQKMQLGYRLQQI 384
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
1311-1890 5.87e-132

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 419.40  E-value: 5.87e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1311 GIPFLDYRTYTMRVLFPGI------------------------EDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLL 1366
Cdd:cd12788     2 GIPFLEYKHFVTRTFFPKCsslyeeryvlpsqennsqgprqvpETHPLLQEWKIPESCRPNMEEGITLFSTLLNNKHFLV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1367 SFIRTLESQRSFSMRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNlESKNhPKLLLRRTESVAEKMLTNWFTFLL 1446
Cdd:cd12788    82 TFVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDAS-ASKN-PKLMLRRTESVVEKMLTNWMSICM 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1447 YKFLKECAGEPLFSLFCAIKQQMEKGPIdaitgearyslsedklirqqidyktlvlscvspdnanspevpvkilncdtit 1526
Cdd:cd12788   160 YSYLRETVGEPFFLLLCAIKQQINKGSI---------------------------------------------------- 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1527 qvkekilDAIFKNVPcshrpkaadmdlewrqgsgarmilqdedittkiendwkrlntlahyqvpdgsvvalvskqvtayn 1606
Cdd:cd12788   188 -------DAIKKVLP----------------------------------------------------------------- 195
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1607 avnnstvsrtsaskyenmirytgspdslrsrtpmitpdlesgvkmwhlvknhehgdqkegdrgskmvsEIYLTRLLATKG 1686
Cdd:cd12788   196 --------------------------------------------------------------------EIYLTRLLSTKG 207
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1687 TLQKFVDDLFETIFSTahRGSALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSI 1766
Cdd:cd12788   208 TLQKFLDDLFQAILSI--PEDRPPLAVKYFFDFLEEQAEKRGITDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDH 285
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1767 TDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNT 1846
Cdd:cd12788   286 MDACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYQQIQEMPPLSEQEMNAHLAEESRKYRNEFNT 365
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 578814730 1847 MSALSEIFSYVGKYSEEILGPLDHDDQCGKQKLAYKLEQVITLM 1890
Cdd:cd12788   366 NVAMAEIYKYAKRYRAQIVSALESNPTARRTQLQHKFEQVIALM 409
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
1311-1886 2.40e-129

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 411.33  E-value: 2.40e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1311 GIPFLDYRTYTMRVLF----PGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNV 1386
Cdd:cd12792     1 RIPFLDYKTYTDRVFFlpskDGANDVMITGKLDIPEARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1387 ASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIK 1466
Cdd:cd12792    81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVHSKN-PKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1467 QQMEKGPIDAitgearyslsedklirqqidyktlvlscvspdnanspevpvkilncdtitQVKEKildaifknvpcshrp 1546
Cdd:cd12792   160 HQVEKGPVDA--------------------------------------------------VQKKK--------------- 174
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1547 kaadmdlewrqgsgarmilqdedittkiendwkrlntlahyqvpdgsvvalvskqvtaynavnnstvsrtsaskyenmir 1626
Cdd:cd12792       --------------------------------------------------------------------------------
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1627 ytgspdslrSRTPMITpdlesgvkmwhlvknhehgdqkegdrgskmvsEIYLTRLLATKGTLQKFVDDLFETIFSTahrG 1706
Cdd:cd12792   175 ---------ERTKAIT--------------------------------EIYLTRLLSVKGTLQQFVDNFFRSVLCS---G 210
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1707 SALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSE 1786
Cdd:cd12792   211 AVVPPAVKYFFDFLDEQAEKHDIVDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTE 290
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1787 HRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILG 1866
Cdd:cd12792   291 HKLSRDSPSNKLLYAKEISTYKKMVDDYYKGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIIN 370
                         570       580
                  ....*....|....*....|
gi 578814730 1867 PLDHDDQCGKQKLAYKLEQV 1886
Cdd:cd12792   371 SLEEDPAAQSKQLTLRLQQI 390
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
51-508 6.01e-125

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 399.01  E-value: 6.01e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRiVQTCNEPLTTTNNVNKMLLIDYKENRLIAC 130
Cdd:cd11236     2 FNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPG-CCSCDHPRSPTDNYNKILLIDYSSGRLITC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  131 GSLYQGICKLLRLEDLFKLGEPYHkkeHYLSGVNESGSVFGVI-VSYSNLDDKLFIATAVDGK--PEYFPTISSRKLtkn 207
Cdd:cd11236    81 GSLYQGVCQLRNLSNISVVVERSS---TPVAANDPNASTVGFVgPGPYNNENVLYVGATYTNNgyRDYRPAVSSRSL--- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  208 sEADGMFAyvFHDEFVASMIKIPSDTftiIPDFDIYYVYGFSSGNFVYFLTLQPEmvsppgSTTKEQVYTSKLVRLCKED 287
Cdd:cd11236   155 -PPDDDFN--AGSLTGGSAISIDDEY---RDRYSIKYVYGFSSGGFSYFVTVQRK------SVDDESPYISRLVRVCQSD 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  288 TAFNSYVEVPIGCE-RSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDR 366
Cdd:cd11236   223 SNYYSYTEVPLQCTgGDGTNYNLLQAAYVGKAGSDLARSLGISTDDDVLFGVFSKSKGPSAEPSSKSALCVFSMKDIEAA 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  367 IKErlqscyrgegtldlawlkvkdipcssalltiddnfcgldmNAPLGVSDMVRGIPVFteDRDRMTSVIAYVYKNHSLA 446
Cdd:cd11236   303 FND----------------------------------------NCPLGGGVPITTSAVL--SDSLLTSVAVTTTRNHTVA 340
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578814730  447 FVGTKSGKLKKIRVDGPRgNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11236   341 FLGTSDGQLKKVVLESSS-SATQYETLLVDSGSPILPDMVFDPDGEHLYVMTPKKVTKVPVE 401
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
1312-1890 2.38e-99

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 325.67  E-value: 2.38e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1312 IPFLDYRTYTMRVLFPGIEDHPVLRDLEVP-GYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVASLI 1390
Cdd:cd12789     4 VPFLDYKHFALRTFFPESGGFTHIFTRDDPhDRDQTDKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLFASFL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1391 MTVLQSKLEYATDVLKQLLADLIDKNleSKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQME 1470
Cdd:cd12789    84 TIALQTKLVYLTEILEVLTKDLMDQS--SNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKIN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1471 KGPIDAITgearyslsedklirqqidyktlvlscvspdnanspevpvkilncdtiTQVKEkildaifknvpcshrpkaad 1550
Cdd:cd12789   162 KGPVDVIK-----------------------------------------------FKVKE-------------------- 174
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1551 mdlewrqgsgarmilqdedittkiendwkrlntlahyqvpdgsvvalvskqvtaynavnnstvsrtsaskyenmirytgs 1630
Cdd:cd12789       --------------------------------------------------------------------------------
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1631 pdslrsrtpmitpdlesgvkmwhlvknhehgdqkegdrgskmvseIYLTRLLATKGTLQKFVDDLFETIFSTAHrgSALP 1710
Cdd:cd12789   175 ---------------------------------------------MYLTKLLSTKVAIHSVVEKLFRSIWSLPN--NKAP 207
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1711 LAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLG 1790
Cdd:cd12789   208 VAIKYFFDFLDAQAENKKITDPDVLHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLG 287
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1791 KDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPLDH 1870
Cdd:cd12789   288 KEAPTNKLLYAKDIPQYKEEVKSYYKAIRDLPPLSSSELEEFLTQESKKHENEFNEEVALMEIYKYIVKYFDEILNKLER 367
                         570       580
                  ....*....|....*....|
gi 578814730 1871 DDqcGKQKLAYKLEQVITLM 1890
Cdd:cd12789   368 ER--GLEEVQKQLLHVKALF 385
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
52-508 2.91e-81

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 275.89  E-value: 2.91e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   52 NHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEpLTTTNNVNKMLLIDYKENRLIACG 131
Cdd:cd11276     9 NHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTE-AKMTDNYNKLLLLDSANKTLVVCG 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  132 SLYQGICKLLRLEDLFKL-------GEpyhkkEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKL 204
Cdd:cd11276    88 SLFKGICSLRNLSNISEViyysdtsGE-----KSFVASNDEGVSTVGLISSLKPGNDRVFFVGKGNGSNDNGKIISTRLL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  205 TKNSEADgmfayVFHDEFVASMIKIPsdtftIIPDFDIYYVYGFSSGNFVYFLTLQpemvsPPGSTTKEQVYtskLVRLC 284
Cdd:cd11276   163 QNYDDRE-----VFENYIDAATVKSA-----YVSRYTQQFRYAFEDNNYVYFLFNQ-----QLGHPDKNRTL---IARLC 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  285 KEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLG-VHPDDDLLFTVFSkgqkRKMKSLDESALCIFILKQI 363
Cdd:cd11276   225 ENDHHYYSYTEMDLNCRDGANAYNKCQAAYVSTPGKELAQNYGnSILSDKVLFAVFS----RDEKDSGESALCMFPLKSI 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  364 NDRIKERLQSCYRGE----GTLDLAWLKVKDIPCSSALLTIDDNF-CGLD-MNAPLGVSDMVRG-IPVFTEDRDRMTSVI 436
Cdd:cd11276   301 NAKMEANREACYTGTiddrDVFYKPFHSQKDIICGSHQQKNSKSFpCGSEhLPYPLGSRDELALtAPVLQRGGLNLTAVT 380
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578814730  437 AYVYKNHSLAFVGTKSGKLKKIRVDGPrgnALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11276   381 VAVENGHTVAFLGTSDGRILKVHLSPD---PEEYNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPVQ 449
Sema smart00630
semaphorin domain;
51-482 6.33e-76

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 258.07  E-value: 6.33e-76
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730     51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRivqtCNEPLTTTNNVNK-MLLIDYKENRLIA 129
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECV----SKGKDPPTDCVNYiRLLLDYNEDRLLV 76
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    130 CGS-LYQGICKLLRLEDLFklgepyhkkehylsgvnesgsvfgvivsysnlddklfIATAVD--GKPEYFPTISSRKLTK 206
Cdd:smart00630   77 CGTnAFQPVCRLRNLGELY-------------------------------------VGTVADfsGSDPAIPRSLSVRRLK 119
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    207 NSeadgmfaYVFHDEFVASMIKIPSDtftiipdfdIYYVYGFSSGNFVYFLTLQPEMVsppgSTTKEQVYTSKLVRLCKE 286
Cdd:smart00630  120 GT-------SGVSLRTVLYDSKWLNE---------PNFVYAFESGDFVYFFFRETAVE----DDNCGKAVHSRVARVCKN 179
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    287 DTA--------FNSYVEVPIGC---ERSGVEYRLLQAAYLSKAGAvlgrtlgvhPDDDLLFTVFSKGQkrkmKSLDESAL 355
Cdd:smart00630  180 DVGgprsldkkWTSFLKARLECsvpGEDPFYFNELQAAFLLPPGS---------ESDDVLYGVFSTSS----NPIPGSAV 246
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    356 CIFILKQINDRIKERLQSCYRGEGTLDL----AWLKVKDIPC-----SSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFT 426
Cdd:smart00630  247 CAFSLSDINAVFNGPFKECETSTSQWLPysrgKVPYPRPGTCpnkppSSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFV 326
                           410       420       430       440       450       460
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578814730    427 E--DRDRMTSVIAYV---YKNHSLAFVGTKSGKLKKIRVDGPRGN--ALQYETVQVVDPG-PVL 482
Cdd:smart00630  327 KtdSNYLLTSIAVDRvatDGNYTVLFLGTSDGRILKVVLSESSSSseSVVLEEISVFPDGsPIS 390
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
51-508 2.01e-70

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 244.07  E-value: 2.01e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPlTTTNNVNKMLLIDYKENRLIAC 130
Cdd:cd11245     2 INHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQA-KETDNFNKLLLVNSANGTLVVC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  131 GSLYQGICKLLRLEDLFK-LGEPYHKKE-HYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGK-PEYFPTISSRKLTKN 207
Cdd:cd11245    81 GSLFQGVCELRNLNSVNKpLYRPETPGDkQYVAANEPSVSTVGLISYFKDGLSLLFVGRGYTSSlSGGIPPITTRLLQEH 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  208 SEADgmfayVFHDEFVASMIKipsdtfTIIPDFDIYYVYGFSSGNFVYFLTLQpemvSPPGSTTKEQVYTSklvRLCKED 287
Cdd:cd11245   161 GEMD-----AFSNEVEAKLVV------GSASRYHHDFVYAFADNGYIYFLFSR----RPGTADSTKRTYIS---RLCEND 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  288 TAFNSYVEVPIGCE-RSGVEYRLLQAAYLSKAGAVLgrtlgvhpDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDR 366
Cdd:cd11245   223 HHYYSYVELPLNCTvNQENTYNLVQAAYLAKPGKVL--------NGKVLFGVFSADEASTAAPDGRSALCMYPLSSVDAR 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  367 IKERLQSCYRGEGTLD----LAWLK--VKDIPCSSALLTIDDNFCGLD-MNAPLGVSDMVRGIPVFTEDrDRMTSVIAYV 439
Cdd:cd11245   295 FERTRESCYTGEGLEDdkpeTAYIEynVKSICKTLPDKNVKAYPCGAEhTPSPLASRYPLAAKPILTRN-DMLTAVAVAV 373
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578814730  440 YKNHSLAFVGTKSGKLKKIRVDGprGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11245   374 ENGHTIAFLGDSGGQLHKVYLDP--NHTDFYSTIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPVQ 440
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
51-508 5.67e-65

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 226.70  E-value: 5.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVL------VTHETGPDEDNPKCYPPrivqtCNEPLTTTNNVNKMLLIDYKE 124
Cdd:cd09295     2 DDKILVSFRKDTIYVGAIARIYKVDGGGTRLllscisPELNFGFNEDQKAFCPL-----RRGKWTECINYIKVLQQKGDL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  125 NRLIACGSLY-QGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVsysnlDDKLFIATAVDGKPEYFPTISSRK 203
Cdd:cd09295    77 DILAVCGSNAaQPSCGSYRLDVLVELGKVRWPSGRPRCPIDNKHSNMGVNV-----DSKLYSATDHDFKDGDRPALSRRS 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  204 LTKNSeadgmfayvfhdefvaSMIKIPSDTFTiipdFDIYYVYGFSSG---NFVYFLTLQPemvsPPGSTTKEQVYTSKL 280
Cdd:cd09295   152 SNVHY----------------LRIVVDSSTGL----DEITFVYAFVSGdddDEVYFFFRQE----PVEYLKKGMVYVPRI 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  281 VRLCKEDTA--------FNSYVEVPIGCER--SGVEYRLLQAAYLSKAGAvlgrtlgvhpDDDLLFTVFSKGQkrkmKSL 350
Cdd:cd09295   208 ARVCKLDVGgchrlkkkLTSFLKADLNCSRpqSGFAFNLLQDATGDTKNL----------IQDVKFAIFSSCL----NKS 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  351 DESALCIFILKQINdrikerlqscyrgegtldlawlkvkdipcssalLTIDDNFCGLDmNAPLGVSDMVrgipvftedRD 430
Cdd:cd09295   274 VESAVCAYLFTDIN---------------------------------NVFDDPVEAIN-NRPLYAHQNQ---------RS 310
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  431 RMTSVIAYVYK----NHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVP 506
Cdd:cd09295   311 RLTSIAVDATKqksvGYQVVFLGLKLGSLGKALAFFFLYKGHIIEEWKVFKDSSRITNLDLSRPPLYLYVGSESGVLGVP 390

                  ..
gi 578814730  507 VE 508
Cdd:cd09295   391 VQ 392
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
1485-1597 7.02e-63

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


Pssm-ID: 466321  Cd Length: 113  Bit Score: 209.74  E-value: 7.02e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1485 LSEDKLIRQQIDYKTLVLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDLEWRQGSGARMI 1564
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIFEEGEVSESVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHGRGGRLI 80
                           90       100       110
                   ....*....|....*....|....*....|...
gi 578814730  1565 LQDEDITTKIENDWKRLNTLAHYQVPDGSVVAL 1597
Cdd:pfam20170   81 LQDEDSTSKVEGGWKKLNTLAHYKVPDGATLAL 113
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
47-507 1.53e-58

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 209.28  E-value: 1.53e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   47 PAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPlTTTNNVNKMLLIDYKENR 126
Cdd:cd11277     4 PNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQA-RLTDNANKLLLVSERAGE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  127 LIACGSLYQGICKLLRLED----LFKLGEPyhkKEHYLSGVNESG-SVFGVIVSYSNLdDKLFIATAVDGK-PEYFPTIS 200
Cdd:cd11277    83 LVACGQVRQGVCEKRRLGNvaqvLYQAEDP---GDGQFVAANDPGvATVGLVVEAPGR-DLLLVGRGLTGKlSAGIPPLT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  201 SRKLTKnseadgmfAYVFHDEFVASMikipsdtftIIPDFDIY---YVYGFSSGNFVYFLtlqpemVSPPGSTTKEQvYT 277
Cdd:cd11277   159 IRQLAG--------AQAFSSEGLGKL---------VVGDFSDYnnsYVGAFAHNGYVYFL------FRRRGARAQAE-YR 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  278 SKLVRLCKEDTAFNSYVEVPIGCERSgveYRLLQAAYLSkagavlgrtlgvhPDDDLLFTVFSKGQKRKMKSLDESALCI 357
Cdd:cd11277   215 TYVARVCLGDTNLYSYVEVPLVCQGG---YNLAQAAYLA-------------PGQGTLFVVFAAGQGSTPTPTDQTALCA 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  358 FILKQINDRIKERLQSCYRGEGtldlawlkvKDIP--------------CSSALLTIDDNF-CGLDMN-APLGVSDMVRG 421
Cdd:cd11277   279 YPLVELDSAMERARRLCYTAGG---------GGPNgkeeatieygvtsrCVNLPKDSPESYpCGDEHTpSPIASRQPLEA 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  422 IPVFTeDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNAlqYETVQVVDPG-PVLRDMAFSKDHEQLYIMSER 500
Cdd:cd11277   350 EPLLT-LTPPLTAVAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQV--YSSQPVGPPGsAVNPDLLLDATGSHLYVLTAR 426

                  ....*..
gi 578814730  501 QLTRVPV 507
Cdd:cd11277   427 QVTKVPV 433
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
51-507 1.75e-57

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 207.12  E-value: 1.75e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPlTTTNNVNKMLLIDYKENRLIAC 130
Cdd:cd11275     8 FLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-QHTNNHNKLLLVNPVQKELIVC 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  131 GSLYQGICKLLRLEDLfklgepyhkkEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYF-------------- 196
Cdd:cd11275    87 GSVHQGICEKRRLGSI----------DHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFvgrgytsrgvgggi 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  197 PTISSRKLTKNSEADGMFAYVFHDEFVASMikipsdTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSppgsttKEQVY 276
Cdd:cd11275   157 PPITTRNLRAHGDDATDSHSIFSYEETAKL------AVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKS------QSREY 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  277 TSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVhPDDDLLFTVFSKGQKRKMKSLDESALC 356
Cdd:cd11275   225 KTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLD-TDGEVLFAAFSAWQASSGKLSEESALC 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  357 IFILKQINDRIKERLQSCY----RGEGTLDLAWLKVkDIPCSSALL---TIDDNFCGLDMN-APLGVSDMVRGIPVFTED 428
Cdd:cd11275   304 AYPMDEVDRLTNWTRDVCYtrdgKAEDGTEVAYIEY-DVSSNCVQLpadTLDAYPCGSDHTpSPMASRVPLEATPLLEWT 382
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578814730  429 RDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVdGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPV 507
Cdd:cd11275   383 EIRLTAVAVNVEDGHTIAFLGDSRGRLHKVYL-GAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPI 460
Sema_MET_like cd11248
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ...
54-507 2.43e-48

The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.


Pssm-ID: 200509 [Multi-domain]  Cd Length: 467  Bit Score: 180.69  E-value: 2.43e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   54 LVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPdEDNPKCypprivQTCN------EPLTTTNNVNKMLLID-YKENR 126
Cdd:cd11248    13 IVLNEGSTEVYVAAQNVIYALNPDLQKVWEYKTGP-VGSPDC------QTCQdcssgaDPGVPKDTDNMVLVLEtYYDDY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  127 LIACGSLYQGICKLLRLEDLFKLGEP----YHKKE---HYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDgkPEYFP-- 197
Cdd:cd11248    86 LYSCGSTQNGVCYRHVLEDGADIQSEvhclFSKKNnspSYCPDCVASPLGTKVTNVESGRTIYFFVANSVN--SSLAGsf 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  198 ---TISSRKLtKNSEaDGmfayvFHDEFvASMIKIPS--DTFTIipdfdiYYVYGFSSGNFVYFLTLQPEMVSPPGSTtk 272
Cdd:cd11248   164 pphSISVRRL-KEDG-FG-----FLSDQ-SYLDVLPSlrDSYPI------KYVYSFHSGPFVYFLTVQRESLTKPSSA-- 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  273 eqvYTSKLVRLCKEDTAFNSYVEVPIGC------ERSGVE----YRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKG 342
Cdd:cd11248   228 ---FHTRLVRLCSSDSEIWRYREMPLECiftpkrRRRSTEedvvYNVLQAAHVSKVGADLADELGASEGDDILFGVFARS 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  343 QKRKMKSLDESALCIFILKQINDRIKERLQSC--------YRGEGtldlawlkvKDIPCSSalLTIDDNFCGLDMNA-PL 413
Cdd:cd11248   305 KPDSGEPMPNSALCAFPIKYVNDAIEKGVEKCctsglehfSGSLC---------HFQPCPT--CPGESSSCEATCKEyRT 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  414 GVSDMVRGIPVFT-EDRD-RMTSVIAYVYKNHSLAFVGTKSGKLKKIRVD--GPRGNAlQYEtvqvVDPGPVLRDMAFSK 489
Cdd:cd11248   374 EVTKPYQRVDLFNgQMSNvLLTSILVTTIGNHTVAHLGTSDGRVLQVVLSrsGPIPHV-NFS----LDSQPVSREVAVLS 448
                         490
                  ....*....|....*...
gi 578814730  490 DHEQLYIMSERQLTRVPV 507
Cdd:cd11248   449 SNGSLLFVTGDKITKVPL 466
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
1040-1140 3.88e-47

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 164.13  E-value: 3.88e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINiCEVLNATEMTCQAPALALGPDHQsDLTERPEEFG 1119
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTS-CKVRNSTLMTCPAPSLALLNRSP-EPGERPVEFG 78
                          90       100
                  ....*....|....*....|.
gi 578814730 1120 FILDNVQSLLILNKTNFTYYP 1140
Cdd:cd01181    79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
708-802 1.00e-39

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 142.80  E-value: 1.00e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   708 DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMeINNLPVELTVVWNG 787
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGS-SGELPATFYVTWNG 79
                           90
                   ....*....|....*
gi 578814730   788 HFNIDNPAQNKVHLY 802
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
Sema_MET cd11278
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ...
61-365 9.82e-39

The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.


Pssm-ID: 200539 [Multi-domain]  Cd Length: 492  Bit Score: 152.71  E-value: 9.82e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   61 GHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPpriVQTCNEPLTTTN-----NVNKMLLI-DYKENRLIACGSLY 134
Cdd:cd11278    36 HHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFP---CQDCSDKANLSNgvwkdNVNMALFVeTYYDDQLISCGSVN 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  135 QGICKllrlEDLFKLGEPYHKKEH----YLSGVNESG--------SVFG--VIVSYSNLDDKLFIATAVDG---KPEYFP 197
Cdd:cd11278   113 RGTCQ----RHVFPHDHPADIQSEvhciYSPQIEEEPdqcpdcvvSTLGskVLVTVKDRFVNFFVGNTINSsyfPDHPLH 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  198 TISSRKLTKNSeaDGmFAYVFHDEFVasmikipsdtfTIIPDF-DIY---YVYGFSSGNFVYFLTLQPEmvsppgsTTKE 273
Cdd:cd11278   189 SISVRRLKETQ--DG-FEFLTDQSYI-----------DVLPEFrDSYpikYVHAFESNNFVYFLTVQRE-------SLDS 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  274 QVYTSKLVRLCKEDTAFNSYVEVPIGC-------ERS--GVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQK 344
Cdd:cd11278   248 QTFHTRIIRFCSIDSELRSYMEMPLECiftekrrKRStkKEVFNILQAAYVSKPGAQLAREMGASLNDDILFGVFAQSKP 327
                         330       340
                  ....*....|....*....|.
gi 578814730  345 RKMKSLDESALCIFILKQIND 365
Cdd:cd11278   328 DSAEPMNRSAVCAVSIKTINE 348
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
955-1038 6.20e-35

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 128.50  E-value: 6.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVF 1034
Cdd:cd01179     2 SITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDGARRLAPLVF 81

                  ....
gi 578814730 1035 QYVE 1038
Cdd:cd01179    82 TYTE 85
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
310-488 3.79e-31

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 121.61  E-value: 3.79e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   310 LQAAYLSKAGAVLGRtlgvhpdDDLLFTVFSKGQKrkmKSLDESALCIFILKQINDRIKERlqscYRGEGTLDLAWLKV- 388
Cdd:pfam01403    1 LQDVFVLKPGAGDAL-------DTVLYGVFTTQWS---NSIGGSAVCAFSLSDINAVFEGP----FKEQEKSDSKWLPYt 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   389 ------KDIPC--SSALLTIDDNFCGLDMNAPLGVS--DMVRGIPVFTEDRDRMTSVIAY----VYKNHSLAFVGTKSGK 454
Cdd:pfam01403   67 gkvpypRPGTCinDPLRLDLPDSVLNFVKDHPLMDEavQPVGGRPLLVRTGVRLTSIAVDrvqaLDGNYTVLFLGTDDGR 146
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 578814730   455 LKKIrVDGPRGNALQYETVQVVDPG-PVLRDMAFS 488
Cdd:pfam01403  147 LHKV-VLVGSEESHIIEEIQVFPEPqPVLNLLLSS 180
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
54-507 2.98e-29

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 124.12  E-value: 2.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   54 LVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPdEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYKENRLIACGSL 133
Cdd:cd11279    32 IVSYEDASAVFVATRNHLHVLNPELKLLQNLVTGP-TGSPGCQICALCPPGPPGPSPEDTDNKVLVLDPEEPWLYSCGSS 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  134 YQGICKLLRLE---DLFKLGEP---YHKKEHYLSGVNES-GSVFG--VIVSYSNLDDKLFIATAVDGK--PEYFPT-ISS 201
Cdd:cd11279   111 LHGRCFLHELEsrgSAVHIASTaclFSANANKPSDCPDCvASPLGtrVTVVEQSHTSYFYVASTLNSSvaASYSPRsVSI 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  202 RKLtkNSEADGmFAYVFHdefvasmikipsdTFTIIPDF----DIYYVYGFSSGNFVYFLTLQPEmvSPPGSTtkeqvYT 277
Cdd:cd11279   191 RRL--KSDQDG-FAPGFH-------------SLTVLPKYldsyPIHYVHSFTSGDFVYFLTVQPE--SPDSSA-----YH 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  278 SKLVRLCKEDTAFNSYVEVPIGC------------ERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKR 345
Cdd:cd11279   248 TRLVRLSAKEPELRDYRELVLDCrfepkrrrrrrpAEREVPYNVLQAAHAAPVGSKLAVELGISEGQEVLFGVFAESQPG 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  346 KMKSLDESALCIFILKQINDRIKERLQSC---------YRGegtldLAWLKVK----DIPCSSALLTidDNFCgldMNAP 412
Cdd:cd11279   328 SPVPQKNSAVCAFPISLLNEAIDEGMEKCcsssnsdrlFRG-----LDFFQPQsycpHPPNLSAAVS--NTSC---WNFP 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  413 LGVSDMVRGIPVFTEDRD--RMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKD 490
Cdd:cd11279   398 TLVSTSSFRVDLFNGHLSgvLLTSIYVTVLDNVTVAHLGTSDGRILQVVLQRSLNYLLYVSNFSLGDGQPVQRDVSRLGD 477
                         490
                  ....*....|....*..
gi 578814730  491 HeqLYIMSERQLTRVPV 507
Cdd:cd11279   478 S--LLFASGNQVFKVNI 492
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
52-507 1.48e-27

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 118.80  E-value: 1.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   52 NHLVVDERTGHIYLGAVNRIYKLS-SDLKVLVTHETGPDEDNPKCYPPRIVQ-TCNEPLTTTNNVNKMLLIDYKENRLIA 129
Cdd:cd11247    12 NNFALDGGRGRLYLAAVNRLYQLSgLVLALEAEAAVGPVLDSPLCHAPQLPQaTCEHPRTLTDNYNKILQPDPEQGVLVV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  130 CGSLYQGICKLLRLEDLFKLGEPYHKK-----EHYLS--GVNESGSVFGVIVSYSN--LDDKLFIATAVDGK-PEYF--- 196
Cdd:cd11247    92 CGSIYQGLCQLRRLYNISAVAVRFPVDgdtvfPSMLNvaANHPNASTVGLVLWPRGggGGLRLLVGATYTGYgSGFFprn 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  197 -----------PTISSRKLTKNSEADGMFAYVFHdefvasmikiPSDT--FTIIPDFDIYYVYGFSSGNFVYFltLQP-- 261
Cdd:cd11247   172 rsledhrfentPEIAIRALNTRGDLAKLFTFDIN----------PSDDniFKIKQGAKARHKLSFVRAFLQHF--LQPya 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  262 --EMVSPPGSTTKEQVYTSKLVRLCKEDTAFN----------SYVEVPIGCERSGveyrllqaaylskagavlGRTLGVH 329
Cdd:cd11247   240 ylAMNGEANAAGKESQPPSLLARICLPGRAPPppgeakklteSYIQLGLRCEGAY------------------TRLVSVF 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  330 P---DDDLLFTVFSKGQKrkmkslDESALCIFILKQINDRIKERLQSCYRGEGTLDLAWL----KVKDIPCSSAL---LT 399
Cdd:cd11247   302 ParvEEEQLFAVFERAGG------APAALCAFRFAEVEEPIRAARTACFVSPAAGVVTVLdsvvQGTGPACERKLniqLQ 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  400 IDDNFCG-LDMNAPLGVSDMVRGIPVFTEdrDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRgNALQYETVQVVDP 478
Cdd:cd11247   376 PEQLDCGaAHLQHPLAILQPLKATPVFRA--PGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESM-QVVSRRSVTVAYG 452
                         490       500       510
                  ....*....|....*....|....*....|
gi 578814730  479 GPVLRDMAFS-KDHEQLYIMSERQLTRVPV 507
Cdd:cd11247   453 EPVHHVMQFDpSDSTYLYLMTSHQMTRVKV 482
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
858-953 3.87e-27

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 106.63  E-value: 3.87e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVC 937
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNGPVEVTVGHG 80
                          90
                  ....*....|....*.
gi 578814730  938 rpEFMARSSQLYYFMT 953
Cdd:cd01180    81 --SFRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
564-654 4.23e-24

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 97.73  E-value: 4.23e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   564 HPNNISVSQY-NVLLVLEtyNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIiTENGDHHVVQLQLKSKET 642
Cdd:pfam17960    1 TPDNISRTTAtQLTLTVP--NLPALSEGYSCVFGDLTESPATVHDNGVKCATPPPSQLPPI-PTGQDHVTVKLSLRSSET 77
                           90
                   ....*....|..
gi 578814730   643 GMTFASTSFVFY 654
Cdd:pfam17960   78 GVDFASTNFTFY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
955-1038 7.64e-21

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 88.67  E-value: 7.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGS-NVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRA----KIH 1029
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSpRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGAnvsaRVL 81

                  ....*....
gi 578814730 1030 QDLVFQYVE 1038
Cdd:cd00603    82 SNTTFTYVE 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
954-1038 2.44e-18

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 81.35  E-value: 2.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMF-GKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRA---KIH 1029
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVDRGnggITS 80

                  ....*....
gi 578814730 1030 QDLVFQYVE 1038
Cdd:cd00102    81 SPLTFTYVP 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
858-952 8.27e-16

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.41  E-value: 8.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIAshVKVAGVECSPLVDGyipAEQIVCEMGEAKPSQHAGfVEICVAVC 937
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVR--VTVGGVPCKVLNVS---STEIVCRTPAAATPGEGP-VEVTVDGA 74
                          90
                  ....*....|....*
gi 578814730  938 RPEFMARSSQLYYFM 952
Cdd:cd00603    75 NVSARVLSNTTFTYV 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-548 2.53e-14

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 68.73  E-value: 2.53e-14
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578814730    510 CGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEP 548
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
IPT smart00429
ig-like, plexins, transcription factors;
1039-1139 6.92e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 68.99  E-value: 6.92e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   1039 DPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEhiniCEVLN--ATEMTCQAPalalgPDHQSDLTERPE 1116
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP----CTFSPssSTAIVCKTP-----PYHNIPGSVPVR 71
                            90       100
                    ....*....|....*....|...
gi 578814730   1117 EFGFILDNVQSLlilnKTNFTYY 1139
Cdd:smart00429   72 TVGLRNGGVPSS----PQPFTYV 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
1040-1140 8.87e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 68.64  E-value: 8.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQnPQIRAKHGGKEhiniCEVLN--ATEMTCQAPALALGPdhqsdltERPEE 1117
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGVP----CKVLNvsSTEIVCRTPAAATPG-------EGPVE 68
                          90       100
                  ....*....|....*....|...
gi 578814730 1118 FGFILDNVqSLLILNKTNFTYYP 1140
Cdd:cd00603    69 VTVDGANV-SARVLSNTTFTYVE 90
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
509-551 1.47e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 66.58  E-value: 1.47e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 578814730   509 SCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRF 551
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEGNCEE 43
IPT smart00429
ig-like, plexins, transcription factors;
857-950 1.65e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 67.83  E-value: 1.65e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    857 NPRITEIIPVTGPREGGTKVTIRGENLGlEFRDIASHVKVAGVECSPLVDGyipAEQIVCEMGEAKPSQHAGFVEiCVAV 936
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVR-TVGL 75
                            90
                    ....*....|....
gi 578814730    937 CRPEFMARSSQLYY 950
Cdd:smart00429   76 RNGGVPSSPQPFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
954-1036 6.95e-13

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 65.93  E-value: 6.95e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGS-NVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLeMKVSVQV-DRAKIHQD 1031
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGL-VNVSVTVgGGGISSSP 79

                   ....*
gi 578814730  1032 LVFQY 1036
Cdd:pfam01833   80 LTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
858-950 2.36e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 64.40  E-value: 2.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRdiaSHVKV-AGVECSPLVDGyipAEQIVCEMGEAKPSQHagfVEICVAV 936
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN---LRVTFgGGVPCSVLSVS---STAIVCTTPPYANPGP---GPVEVTV 71
                          90
                  ....*....|....
gi 578814730  937 CRPEFMARSSQLYY 950
Cdd:cd00102    72 DRGNGGITSSPLTF 85
IPT smart00429
ig-like, plexins, transcription factors;
954-1037 6.24e-12

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 63.21  E-value: 6.24e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730    954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMF--GKQPCLFHRRSPSYIVCNTTS-SDEVLEMKVS-VQVDRAKIH 1029
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPyHNIPGSVPVRtVGLRNGGVP 81

                    ....*....
gi 578814730   1030 -QDLVFQYV 1037
Cdd:smart00429   82 sSPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
858-937 4.43e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.54  E-value: 4.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIasHVKVAGVECSPLvdgYIPAEQIVCEMgeakPSQHAGFVEICVAVC 937
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVI---SVSSTTIVCTT----PPGTSGLVNVSVTVG 71
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
1040-1140 2.24e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 59.01  E-value: 2.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDliQNPQIRAKHGGKEHINIcEVLNATEMTCQAPALALGPDHQSDLTerpeefg 1119
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFG--SGSNLRVTFGGGVPCSV-LSVSSTAIVCTTPPYANPGPGPVEVT------- 70
                          90       100
                  ....*....|....*....|.
gi 578814730 1120 fiLDNVQSLLILNKTNFTYYP 1140
Cdd:cd00102    71 --VDRGNGGITSSPLTFTYVP 89
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
53-507 9.23e-10

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 63.20  E-value: 9.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   53 HLVVDERTGHIYLGAVNRIYKLS----SDLKVLVTHETGPDEDnpKCYPPRIVQT-CnepltttNNVNKMLLiDYKENRL 127
Cdd:cd11235     5 TKLLHEDRSTLYVGARDRVYLVDldslYTEQKVAWPSSPDDVD--TCYLKGKSKDdC-------RNFIKVLE-KNSDDSL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  128 IACGS-LYQGICKLLRLED---LFKLGE-----PYHKKEHYLSgvnesgsvfgvIVSysnlDDKLFIATAVD---GKPEY 195
Cdd:cd11235    75 LVCGTnAFNPSCRNYNVETfelVGKEESgrgkcPYDPDHNSTA-----------LFA----DGELYSGTSADflgTDPVI 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  196 FPTISSRKLTKNSEADgmfayvfhdefvasmikipsDTFTIIPDFdiyyVYGFSSGNFVYFLTLQpemVSPPGSTTKEQV 275
Cdd:cd11235   140 YRTLGHNPPLRTEYHD--------------------SKWLNEPQF----VGAFDIGDYVYFFFRE---IAVEYINCGKAV 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  276 YtSKLVRLCKEDT--------AFNSYVEVPIGCERSG---VEYRLLQAAYLSKAGAvlgrtlgvhPDDDLLFTVFSKgqk 344
Cdd:cd11235   193 Y-SRVARVCKNDQggsrslekKWTTFLKARLNCSVPGefpFYFNELQDVFDLPSPS---------NKEKIFYAVFTT--- 259
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  345 rKMKSLDESALCIFILKQINdrikERLQSCYRGEGTLDLAWLKVKD-IPCSSALLT-IDD--NFCGLDMN----APLgVS 416
Cdd:cd11235   260 -PYNSIPGSAVCAYSLSDIE----AVFNGPFKEQHSSNSAWLPVPDeRVPEPRPGTcVDDssPLPDDTLNfiksHPL-MD 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  417 DMVRGI---PVF--TEDRDRMTSVI-----AYVYKNHSLAFVGTKSGKLKKIRVdgPRGNALQ----YETVQVVDPGPVL 482
Cdd:cd11235   334 EAVTPIlnrPLFikTDVNYRFTKIAvdrvqAKLGQTYDVLFVGTDRGIILKVVS--LPEQGLQasniLEEMPVGPPPEPI 411
                         490       500
                  ....*....|....*....|....*
gi 578814730  483 RDMAFSKDHEQLYIMSERQLTRVPV 507
Cdd:cd11235   412 QTMQLSRKRRSLYVGSETGVLQVPL 436
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
804-856 8.96e-09

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 53.10  E-value: 8.96e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 578814730   804 CGAMReSCGLCLKADpDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCT 856
Cdd:pfam01437    2 CSQYT-SCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKCP 52
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
1664-1818 2.65e-08

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 57.12  E-value: 2.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1664 KEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRgsaLPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCL 1743
Cdd:cd04519   104 ESKESCEIDTKLPVGEDLEENLENLLELVNKLVDRILSSLDR---LPPELRYVFKILREFLAERFPEEPDEAYQAVSGFL 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1744 PLRFWVNMIKNPQFvFDIHKNSITD---ACLSVVAQTFMDSCSTSEhrlgkdsPSNKLLYAKD----IPSYKNWVERYYS 1816
Cdd:cd04519   181 FLRFICPAIVSPEL-FGLVPDEPSEqarRNLTLISKVLQSLANGVE-------FGDKEPFMKPlndfIKSNKPKLKQFLD 252

                  ..
gi 578814730 1817 DI 1818
Cdd:cd04519   253 EL 254
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
655-702 2.82e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.55  E-value: 2.82e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 578814730   655 NCSVHNSCLSCVESP-YRCHWCKYRHVCTHdPKTCSFQEGR----VKLPEDCP 702
Cdd:pfam01437    1 RCSQYTSCSSCLAARdPYCGWCSSEGRCVR-RSACGAPEGNceewEQASSKCP 52
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
958-1038 1.58e-07

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 50.78  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  958 DLKPSRGPMSGGTQVTITGTNLN---AGSNVVVMFGKQPC--LFHRRSPS-YIVCNT-TSSDEVLEMKVSVQVDR--AKI 1028
Cdd:cd01180     5 EFFPLSGPLEGGTRLTICGSNLGlrkNDVRHGVRVGGVPCnpEPPEYSSSeKIVCTTgPAGNPVFNGPVEVTVGHgsFRT 84
                          90
                  ....*....|
gi 578814730 1029 HQDLVFQYVE 1038
Cdd:cd01180    85 ESSEGFSFVD 94
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
655-702 3.23e-07

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 48.70  E-value: 3.23e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 578814730    655 NCSVHNSCLSCVESPY-RCHWCKYRHVCTHDPkTCSFQEGRVkLPEDCP 702
Cdd:smart00423    1 RCSKYTSCSECLLARDpYCAWCSSQGRCTSGE-RCDSRRQNW-LSGGCP 47
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
1142-1222 5.11e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.38  E-value: 5.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1142 PVFEAFGPS-GILElkPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTVT-VSDVQLLCESP--NLIGRHKVMARVG 1217
Cdd:cd00603     1 PVITSISPSsGPLS--GGTRLTITGSNL------GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPaaATPGEGPVEVTVD 72

                  ....*
gi 578814730 1218 GMEYS 1222
Cdd:cd00603    73 GANVS 77
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
51-505 6.37e-07

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 53.97  E-value: 6.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLkvlVTHETGPDEDNPKCYPPRIVQTC-----NEPLTTTNNVNKMLLIDyKEN 125
Cdd:cd11238     3 YRTLLLDEKRNALYVGAMDRVFRLNLYN---INDTGNNCARDELTLSPSDVSECvskgkDEEYECRNHVRVIQPMG-DGQ 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  126 RLIACGSlyQGICKLLRLEDLFKLGEPyhkkeHYLSGVnesGSVFGVIVSysnldDKLFIATAV---DGKPEYFPTISSR 202
Cdd:cd11238    79 TLYVCST--NAMNPKDRVLDANLLHLP-----EYVPGP---GNGIGKCPY-----DPDDNSTAVwveWGNPGDLPALYSG 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  203 KLTKNSEADgmfAYVFH--------DEFVASMIKIPSDTFTII-PDFdiyyVYGFSSGNFVYFL--TLQPEMVSPpgstt 271
Cdd:cd11238   144 TRTEFTKAN---TVIYRpplynntkGRHESFMRTLKYDSKWLDePNF----VGSFDIGDYVYFFfrETAVEYINC----- 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  272 kEQVYTSKLVRLCKEDTA--------FNSYVEVPIGCERSGvEYRL----LQAAYlskagAVLGRtlgvhpDDDLLFTVF 339
Cdd:cd11238   212 -GKVVYSRVARVCKKDTGgknvlrqnWTTFLKARLNCSISG-EFPFyfneIQSVY-----KVPGR------DDTLFYATF 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  340 SKGQkrkmKSLDESALCIFILKQINDRIkerLQSCYRGEGTLDLAWLKV--KDIP------CSSALLTIDDNFCGLDMNA 411
Cdd:cd11238   279 TTSE----NGFTGSAVCVFTLSDINAAF---DTGKFKEQASSSSAWLPVlsSEVPeprpgtCVNDSATLSDTVLHFARTH 351
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  412 PLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFV----GTKSGKLKKIrVDGPRGNALQYETVQV--VDPGPVLRDM 485
Cdd:cd11238   352 PLMDDAVSHGPPLLYLRDVVFTHLVVDKLRIDDQEYVvfyaGSNDGKVYKI-VHWKDAGESKSNLLDVfeLTPGEPIRAM 430
                         490       500
                  ....*....|....*....|
gi 578814730  486 AFSKdHEQLYIMSERQLTRV 505
Cdd:cd11238   431 ELLP-GEFLYVASDHRVSQI 449
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
806-849 6.73e-07

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 47.54  E-value: 6.73e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 578814730    806 AMRESCGLCLKAdPDFACGWCQGPGQCTLRQHCPAQESQWLELS 849
Cdd:smart00423    3 SKYTSCSECLLA-RDPYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
1142-1226 1.32e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.13  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730  1142 PVFEAFGPSGIlELKPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTV-TVSDVQLLCESPNL-IGRHKVMARVGGM 1219
Cdd:pfam01833    1 PVITSISPSSG-PASGGTTITITGSNF------GTDSSDLKVTIGGTPCTViSVSSTTIVCTTPPGtSGLVNVSVTVGGG 73

                   ....*..
gi 578814730  1220 EYSPGMV 1226
Cdd:pfam01833   74 GISSSPL 80
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
508-542 8.41e-05

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 41.77  E-value: 8.41e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 578814730   508 ESC-GQYQSCGECLGSGdPHCGWCVLHNTCTRKERC 542
Cdd:pfam17205    1 NRCtSASTSCEECIQSG-PDCAWCTDENFTSGSPRC 35
IPT smart00429
ig-like, plexins, transcription factors;
1141-1204 1.70e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.02  E-value: 1.70e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578814730   1141 NPVFEAFGP-SGILElkPGTPIILKGKNLIPpvaGGNVKlnYTVLVGEKPCTVT-VSDVQLLCESP 1204
Cdd:smart00429    1 DPVITRISPtSGPVS--GGTEITLCGKNLKS---ISVVF--VEVGVGEAPCTFSpSSSTAIVCKTP 59
Ubl_SF3a120 cd01800
ubiquitin-like (Ubl) domain found in splicing factor 3A 120kDa subunit (SF3a120) and similar ...
1507-1600 3.27e-03

ubiquitin-like (Ubl) domain found in splicing factor 3A 120kDa subunit (SF3a120) and similar proteins; Mammalian splicing factor SF3a consists of three subunits of 60, 66, and 120 kDa and functions early during pre-mRNA splicing by converting the U2 snRNP to its active form. The 120kDa subunit SF3a120, also termed splicing factor 3A subunit 1 (SF3A1), or spliceosome-associated protein 114 (SAP114), is the U2 snRNP-specific protein that is critical for spliceosome assembly and normal splicing events. During splicing, SF3a120, together with the U2 snRNP and other proteins, are recruited to the 3' splicing site to generate the splicing complex A after the recognition of the 3' splicing site. SF3a120 contains two N-terminal SWAP (suppressor-of-white-apricot) domains, referred to collectively as the SURP module, as well as a C-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions.


Pssm-ID: 340498  Cd Length: 84  Bit Score: 38.32  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814730 1507 PDNANSPE-------VPVKILNCDTITQVKEKILDAIfkNVPcshrpkAADMDLEWRQGsgarMILQDEdittkiendwk 1579
Cdd:cd01800     9 PNVPDKPEwklngqvLELTLPLTDTISVLKEKIHEEL--GMP------ANKQKLQVEGG----GFLKDS----------- 65
                          90       100
                  ....*....|....*....|.
gi 578814730 1580 rlNTLAHYQVPDGSVVALVSK 1600
Cdd:cd01800    66 --NSLAFYNLGSGTVLTLSLK 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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