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Conserved domains on  [gi|578816110|ref|XP_006716680|]
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CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 59-338 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


:

Pssm-ID: 467708  Cd Length: 280  Bit Score: 578.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  59 CTCTHCIGQRKLSAWFDERFNQTMQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVG 138
Cdd:cd23980    1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVV 218
Cdd:cd23980   81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 219 SAITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWH 298
Cdd:cd23980  161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 578816110 299 HYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23980  241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
 
Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 59-338 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 578.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  59 CTCTHCIGQRKLSAWFDERFNQTMQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVG 138
Cdd:cd23980    1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVV 218
Cdd:cd23980   81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 219 SAITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWH 298
Cdd:cd23980  161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 578816110 299 HYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23980  241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 85-333 3.82e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 270.25  E-value: 3.82e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110   85 LLTAQNALLEDdtyrwWLRLQREKKP-NNLNDTIKELFRVVPGnvdpmlekRSVGCRRCAVVGNSGNLRESSYGPEIDSH 163
Cdd:pfam00777   1 FLTKENFPLGE-----WIRYSEWWLPfTVTEELLELLPKVSPF--------DNKRCRRCAVVGNGGILRGSGCGKEIDSH 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  164 DFVLRMNKAPTAGFEADVGTKTTHHLVYPES-----FRELGD------NVSMILVPFKTIDLEWVVSAITTGTISH---- 228
Cdd:pfam00777  68 DFVIRCNLAPTKGYEKDVGSKTTLRTMNPESaidskYGNLGFshprdpFVEFVLVPFKGRDLLWLPAFLTKGNVSRslrv 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  229 TYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHG---RYPSTGILSVIFSMHVCDEVDLYGFGA--DSKGNWHHYWEN 303
Cdd:pfam00777 148 LYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYYDN 227

                         250       260       270
                  ....*....|....*....|....*....|
gi 578816110  304 NPSAgAFRKTGVHDADFESNVTATLASINK 333
Cdd:pfam00777 228 VLMK-KGGFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 59-338 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 578.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  59 CTCTHCIGQRKLSAWFDERFNQTMQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVG 138
Cdd:cd23980    1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVV 218
Cdd:cd23980   81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 219 SAITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWH 298
Cdd:cd23980  161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 578816110 299 HYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23980  241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 61-338 4.34e-170

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 473.69  E-value: 4.34e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  61 CTHCIGQRKLSAWFDERFNQTMQPLLTAQNALLEDDTYRWWLRLQREKKpNNLNDTIKELFRVVPGNvDPMLEKRSVGCR 140
Cdd:cd23966    1 CRRCVQEGGDSDWFDERFNPSIEPLLTRKNKELPPDVLKWWLSLQSSKN-SDLREVLEKLFQVVPGE-NPYRTRDPNRCR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 141 RCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVVSA 220
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVLVPFKVLDLQWLISA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 221 ITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWHHY 300
Cdd:cd23966  159 LTTGEITRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFGADSKGNWHHY 238

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 578816110 301 WENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23966  239 WEKNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRVYR 276
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 59-338 6.19e-136

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 387.69  E-value: 6.19e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  59 CTCTHCIGQRKLSAWFDERFNQTMQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNvDPMLEKRSVG 138
Cdd:cd23979    1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMMLQPQFKPHNTKEVLSKLFQIIPGE-NPYRSWDPSR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVV 218
Cdd:cd23979   80 CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWIT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 219 SAITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWH 298
Cdd:cd23979  160 SALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWH 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 578816110 299 HYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23979  240 HYWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 85-333 3.82e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 270.25  E-value: 3.82e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110   85 LLTAQNALLEDdtyrwWLRLQREKKP-NNLNDTIKELFRVVPGnvdpmlekRSVGCRRCAVVGNSGNLRESSYGPEIDSH 163
Cdd:pfam00777   1 FLTKENFPLGE-----WIRYSEWWLPfTVTEELLELLPKVSPF--------DNKRCRRCAVVGNGGILRGSGCGKEIDSH 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  164 DFVLRMNKAPTAGFEADVGTKTTHHLVYPES-----FRELGD------NVSMILVPFKTIDLEWVVSAITTGTISH---- 228
Cdd:pfam00777  68 DFVIRCNLAPTKGYEKDVGSKTTLRTMNPESaidskYGNLGFshprdpFVEFVLVPFKGRDLLWLPAFLTKGNVSRslrv 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  229 TYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHG---RYPSTGILSVIFSMHVCDEVDLYGFGA--DSKGNWHHYWEN 303
Cdd:pfam00777 148 LYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYYDN 227

                         250       260       270
                  ....*....|....*....|....*....|
gi 578816110  304 NPSAgAFRKTGVHDADFESNVTATLASINK 333
Cdd:pfam00777 228 VLMK-KGGFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 71-338 8.85e-59

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 191.32  E-value: 8.85e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  71 SAWFDERFNQTMQPLLTAqnallEDDTYRWWLRLQREKKPN---NLN-DTIKELFRVVPG-NVDPMLEKRS--VGCRRCA 143
Cdd:cd23964   12 SPWFRERFIPDIKVLLDS-----EDFNPEEYNRLSHYKLPFgwgGLNrEVVERLLRNLNLtSSRYMFVLRGgrPRCIRCA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 144 VVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRE-------LGDNVSMILVPFKTIDLEW 216
Cdd:cd23964   87 VVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNsllkhvpQDKDTKYLFIPFKIRDYDY 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 217 VVSAITTGTI------SHTYIPVPAKiRVKQDKILIYHPAFIKYVFDNWLQGH-GRYPSTGILSVIFSMHVCDEVDLYGF 289
Cdd:cd23964  167 LDAVLSGKPVpdgcdkGKRPPPLFGP-KLNATNVRLLHPDFIRYLFNRWLNSStSYRPTTGALMLLTALHTCDQVSVYGF 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 578816110 290 GADSKGNWHHYweNNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23964  246 GYDPRFSLHYY--DKTFVKFTVFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 142-324 2.42e-55

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 179.10  E-value: 2.42e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 142 CAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKtiDLEWVVSAI 221
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLP--LEEEVVLIL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 222 TTGTISHTYIPVPAKIRVKQDKILIYHPA--FIKYVFDNWLQGH------GRYPSTGILSVIFSMHVCDEVDLYGFGADS 293
Cdd:cd19952   79 SRAAAADFKRLKRRKKRHDNAVLLLTDPApdLLSYVRKRLEKLGlksffgGNAPSSGLLAVLLALQLCDSVDLYGFGVDS 158

                        170       180       190
                 ....*....|....*....|....*....|....
gi 578816110 294 ---KGNWHHYWENnpsAGAFRKTGVHDADFESNV 324
Cdd:cd19952  159 ghaPKVPYHYYDL---VEAEEGTAVHSFDLEAEL 189
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 138-322 6.00e-47

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 157.84  E-value: 6.00e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 138 GCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPES-FR---ELGDNVSMILVPFKTID 213
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESaFRdpeEYDSDWLLVLVPFKSMD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 214 LEW---VVSAITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQ------GHGRYPSTGILSVIFSMHVCDEV 284
Cdd:cd23967   81 LLWlqaVIKGKKPNGKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGlpmngkQGKNVPTTGIIAIVMALHYCDEV 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 578816110 285 DLYGFGADSK--GNWHHYWENNPSAGAFRKTGvHDADFES 322
Cdd:cd23967  161 DIAGFGYDPSdpNAPLHYYDSLTMKAIKRSWT-HNVTKEK 199
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 139-303 4.19e-38

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 134.79  E-value: 4.19e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPES--FRELGDNVS---MILVPFKTID 213
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESaqFDPGIENDPdtlLVLVPFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 214 LEWVVSaITTGTISHTYI---PVPAKIRVKQDKILIYHPAFIKYVFDNWLQ-----GHGRYPSTGILSVIFSMHVCDEVD 285
Cdd:cd23982   82 FYWLYE-ILSNEKRVRKGfwkQPPRIWDANPKQIRILNPYYTYVAATKLLQvpgqrKKKQKPTTGLLAITLALHLCDEVH 160

                        170       180
                 ....*....|....*....|.
gi 578816110 286 LYGFGADSKGN---WHHYWEN 303
Cdd:cd23982  161 IAGFGYPDNGNsnqPIHYYNQ 181
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 139-303 3.05e-36

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 129.87  E-value: 3.05e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESF----RELGDNVSMILVPFKTIDL 214
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIfsdpSHYDPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 215 EWVVSAITTGTIS---HTYIPvPAKIRVKQDKILIYHPAFIKYVFDNWL--------QGHGRYPSTGILSVIFSMHVCDE 283
Cdd:cd23984   82 RWLLDLLMGKKVSakgFWKKP-ALNLIYKPNQIRILNPFILRIAAYELLhfpkrfpkEKKPKHPTTGIIAITLALHICNE 160

                        170       180
                 ....*....|....*....|..
gi 578816110 284 VDLYGFGAD--SKGNWHHYWEN 303
Cdd:cd23984  161 VHIAGFKYDfsNLNSTLHYYGN 182
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 138-321 1.94e-32

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 120.23  E-value: 1.94e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 138 GCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPE----SFRELGDNVSMILVPFKTID 213
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEgapkSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 214 LEWVVSAITTGTIS-----HTYIPVPAKIRVKQDKILIYHPAFIK---YVFDNWLQGHGRY-------PSTGILSVIFSM 278
Cdd:cd23983   81 FAWLKAMVKKEPLSfwsrlFFWKEVADSIPLKPSQFRILNPLIIKetaLDILQYPEPQSRLwgwdknvPTLGVTAVVLAT 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 578816110 279 HVCDEVDLYGFGAD--SKGNWHHYWENNPSAgAFRKTGVHDADFE 321
Cdd:cd23983  161 HLCDEVSLAGFGYDlsQPHAPLHYYDSVCMA-AMNTQTMHNVTKE 204
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 76-305 1.18e-31

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 119.67  E-value: 1.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  76 ERFNQTMQPLLTAQNALLEDDTYRwwlrLQREKKPNNLNDTIKELFRvvpgNVDPMLEKRSvgcRRCAVVGNSGNLRESS 155
Cdd:cd23963   11 ERLLNTRKLFLTQKNTPLGDVLYY----SYFKKKTFKITKSLYELLP----KTSPFSHKRY---KTCAVVGNSGILLGSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 156 YGPEIDSHDFVLRMNKAPTAGFEADVGTKT--------------------THHLVYPESFRELGDnvSMILVP--FKTID 213
Cdd:cd23963   80 CGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsilkrrynslkknRDRDKFLNRLKEYNG--SILWYPkfSFKSS 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 214 LEWVVSAITTgtishtyipvpAKIRVKQDKILIYHPAFIKYVFDNW-LQGHGRYPSTGILSVIFSMHVCDEVDLYGF--- 289
Cdd:cd23963  158 TNLLLKAARA-----------LKKNGLNLTVVYSNPEHFLAVQKFWkRRGLEKRPSTGLYLVSLALTFCDEIHLYGFwpf 226

                        250
                 ....*....|....*...
gi 578816110 290 GADSKGNW--HHYWENNP 305
Cdd:cd23963  227 PTDPNGRPvpYHYYDDLS 244
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 139-303 1.90e-29

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 112.32  E-value: 1.90e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPE----SFRELGDNVSMILVPFKTIDL 214
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEgaiqKPEQYEKDSLFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 215 EWVVSAITTGTIS---------HTYIP-VPAKIRVkQDKILIYHPAF--IKYVFDNWLQGHGRYPSTGILSVIFSMHVCD 282
Cdd:cd23981   82 KWLKYIVYKEKVSasdgfwksvATRVPrEPHEIRI-LNPYFIQEAAFsfIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                        170       180
                 ....*....|....*....|...
gi 578816110 283 EVDLYGFGAD--SKGNWHHYWEN 303
Cdd:cd23981  161 EVAVAGFGYDmnTPNAPLHYYET 183
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 101-339 1.46e-27

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 109.46  E-value: 1.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 101 WLRLQREKKP---NNLNDT-IKELFRVVPGNVDPML----EKRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKA 172
Cdd:cd23973   37 WDRLEHFNPPfgfMGLNYTlVKEVVELIPKPKEQQLlalsPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 173 PTAGFEADVGTKTTHHLVYPES-------FRELG-------DNVSMILVPFKTIDLEWVVSAITTGTIshtyipvPAKIR 238
Cdd:cd23973  117 VIKGYEEDVGTRTSFYVHTAHSitsslmiLQKRGfknipqdKDIKYILFPEGPRDYQWLEALLKNKTI-------PSGAY 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 239 VKQ------------DKILIYHPAFIKYVFDNWLQG---HGRY-----PSTGILSVIFSMHVCDEVDLYGF-GADSKGNW 297
Cdd:cd23973  190 YGRrprsyfsgdfteDKYLVLHPDFLRYVKNRFLRSktlKGKYwaiyrPTTGAFLLLTALHLCDTVSAYGFiTEDYRKYP 269

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 578816110 298 HHYWENNPSAGAFrkTGVHDADFESNVTATLASINKIRIFKG 339
Cdd:cd23973  270 DHYYDKKKTKLVF--YINHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 136-340 4.88e-27

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 107.36  E-value: 4.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 136 SVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTT-----HHLVYPESFRELGD----NVSMIL 206
Cdd:cd23968   42 TKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTlrlinSQILSKPEFNFLTDplyrNVTLLV 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 207 ---VPFKTIDLEWVVSAittgtiSHTYIP--VPAKIRVKQDKILIYHPAFIKYVFDnWLQ------GHGRYPSTGILSVI 275
Cdd:cd23968  122 wdpSSYNVNLEKWYKKP------DFDFFPnyIKYRRRHPEEPFYLIDPRFLWRLWD-ILQeytpekIKPNPPSSGFIGIV 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578816110 276 FSMHVCDEVDLYGFgADSKGNWH--HYWEN----NPSAGAFrktgvHDADFESNVTATLASINKIRIF-KGR 340
Cdd:cd23968  195 LMLHLCDWVDVYEY-VPSVRQTDrcHYYDVekdlACTLGAW-----HPLAAEKLLVRHLNVGSDDDIFrKGR 260
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 61-338 1.14e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 107.22  E-value: 1.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110  61 CTHCIGQR-KLSAWFDERFNQTMqPLLTAQNALLEDDtyrwWLRLQREKKPNN---------------LNDTI-KELF-- 121
Cdd:cd23972    1 CPHSLHLRiQRDPHFRGLFNFDI-PVLLWGQHFTPAL----WDRLSQRKVPYGwkglshqvvastlslLNDSAnAKLFfp 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 122 RVVPGnvdpmlekrsvGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHH----------LVy 191
Cdd:cd23972   76 RDTPG-----------KCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYgftvntmknsLI- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 192 peSFRELG-------DNVSMILVPFKTIDLEWVVSAITTgtishtyIPVPA--------------KIRVKQDKILiyHPA 250
Cdd:cd23972  144 --SYWNLGftrtpqgQDLQYIFIPSDIRDYVMLRSAILG-------VPVPEgldkgdrphkyfgpEASAKKFKLL--HPD 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 251 FIKYVFDNWLQ--------GHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWH-HYWENNPSAGAFRKTgvHDADFE 321
Cdd:cd23972  213 FISYLTDRFLKskllnthyGHLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSdHYYERKKKPLVFYAN--HDMLLE 290

                        330
                 ....*....|....*..
gi 578816110 322 SNVTATLASINKIRIFK 338
Cdd:cd23972  291 AALWRRLHKAGILQLYQ 307
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 103-307 4.09e-24

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 99.41  E-value: 4.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 103 RLQREKKPNNLNDTIKELFRVVPgNVDPMLEKRSvgcRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVG 182
Cdd:cd23969   32 RMHYEIDRHKTVNITQDLYQLLP-EVSPLKGKHF---RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 183 TK----TTHHLVYPESF----------------RELGDnvSMILVP-FKTIDLEWVVSaITTGTISHTYIPVpakirvkq 241
Cdd:cd23969  108 TKsnltTMNPSVIPHAYgdlvnatdkekfverlRQLGD--SILWIPaFVSKGGEEHVQ-WTNEIILKHKLNV-------- 176

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578816110 242 dKILIYHPAFIKYVFDNWLQG--HGRYPSTGILSVIFSMHVCDEVDLYG---FGADSKGN--WHHYWENNPSA 307
Cdd:cd23969  177 -KTAYPPLRLNHAIRGYWLTTkfRIKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRavKYHYYDNRKYL 248
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 139-302 6.11e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 98.01  E-value: 6.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLV-----------YPESFRELGDNVSMILV 207
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVshtsvplllrnQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 208 PFKTIDLEwvVSAITTGTISHTYIPVPakiRVKQDKILIYHPAFIKYVFDNWLQGH----GRYPSTGILSVIFSMHVCDE 283
Cdd:cd23977   81 PERNMDRD--GGGKTYRALLTLAKMYP---HLQVYTLTEEKMAYCDGVFQNETGKNrmksGSFLSTGWFTMILALELCEE 155

                        170       180
                 ....*....|....*....|....*.
gi 578816110 284 VDLYGFGADS--KGNWH-----HYWE 302
Cdd:cd23977  156 ILVYGMVSDSycRNKNHssvpyHYYE 181
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 129-304 5.49e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 97.13  E-value: 5.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 129 DPMLEKRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPE-------SFRELGDN 201
Cdd:cd23974   74 WWDRPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNtlmnslrAYAGVGFN 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 202 -------VSMILVPFKTIDLEWVVSAITtgtisHTYIPV-------PAK---IRVKQDKILIYHPAFIKYVFDNWLQ--- 261
Cdd:cd23974  154 gppqskeTRYIFLPDHDRDYLLVKAALT-----HTPIDRgrdkskrPSKyfgKDVTAEKFKIYHPDFIRYLRNRFLWspi 228

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 578816110 262 ---GHGRY--PSTGILSVIFSMHVCDEVDLYGFGADSKGNWH-HYWENN 304
Cdd:cd23974  229 lntKQRDIyrPSTGAVMLLAALHTCDQVSAYGFMTPDYGKYSdHYYDKT 277
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 139-288 2.71e-22

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 93.46  E-value: 2.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILV----------- 207
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAILLLAgtraptvvvfw 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 208 -PFKTIDLEWVVSAITTGTISHTYiPVPAKIRVKQDKIliyhpAFIKYVFDN-----------WLqghgrypSTGILSVI 275
Cdd:cd23965   81 gPETKMNKDGAGKYNLLRSLSKKY-PDVEFYSLTPEKM-----DYADELFEKetgksriksgtWL-------STGWFTML 147

                        170
                 ....*....|...
gi 578816110 276 FSMHVCDEVDLYG 288
Cdd:cd23965  148 LALDVCDEIKVYG 160
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 141-317 3.26e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 91.55  E-value: 3.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 141 RCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAgFEADVGTKTthHLVYPesfrelgdNVSMILVPFKTidLEW---- 216
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKT--NLVTA--------NPSILREKFHN--LKKrrrp 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 217 -VVSAITTGtisHTYIPVPA---------KIRVK--------QDKILIYHPAFIKYVFDNWL-QG-HGRYPSTGILSVIF 276
Cdd:cd23971  133 fVERMKVYG---NALLLLPAfsytsntepSLRALytledfgsPQKVLFFNPEYLRNLSRYWKsKGlKARRLSTGLMLVSA 209

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578816110 277 SMHVCDEVDLYGF---GADSKGNW--HHYWENNPSagafrKTGVHD 317
Cdd:cd23971  210 ALELCENVHLYGFwpfSTDLDGNPisHHYYDNVLP-----KKGVHA 250
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 128-303 7.75e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 90.40  E-value: 7.75e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 128 VDPMLEKRSvgcRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPE-------SFRELGD 200
Cdd:cd23988   56 VSPMKNRRF---KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafgGFRNESD 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 201 NVSMILVPFKTID-LEWVVSAITTGTISHTYIpVPAKIRVKQDKILIYHPA--FIKYVFDNWLQG--HGRYPSTGILSVI 275
Cdd:cd23988  133 REKFVHRLSMLNDsVLWIPAFMVKGGEKHVEW-VNALILKNKLKVRTAYPSlrLIHAVRGYWLTNkvNIKRPSTGLLMYT 211

                        170       180       190
                 ....*....|....*....|....*....|...
gi 578816110 276 FSMHVCDEVDLYG---FGADSKGN--WHHYWEN 303
Cdd:cd23988  212 LATRFCDEIHLYGfwpFPKDANGNpvKYHYYDD 244
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 140-303 1.29e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 90.15  E-value: 1.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 140 RRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMI---------LVPFK 210
Cdd:cd23970   69 NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNNLLTIqdrnnfflsLKKLD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 211 TIDLeWV------VSAITTGTISHTYIPVPAKIRVKqdkiLIYHPAFIKYVFDNWLQGHG--RYPSTGILSVIFSMHVCD 282
Cdd:cd23970  149 GAIL-WIpafffhTSATVTRTLVDFFVEHRGQLKVQ----LAWPGNIMQHVNRYWKTKHLspKRLSTGILMYTLASAICE 223

                        170       180
                 ....*....|....*....|....*.
gi 578816110 283 EVDLYGF---GADSKGNW--HHYWEN 303
Cdd:cd23970  224 EIHLYGFwpfGFDPTGTPlpYHYYDK 249
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 140-289 3.72e-20

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 88.23  E-value: 3.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 140 RRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTT-----HHLVYPESFRELGDNV--SMILV----- 207
Cdd:cd23985   46 GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTirlinSQLVTTEKHKFLKDSLynEGILIvwdpa 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 208 PFKTIDLEWVVSaiTTGTISHTYipvpAKIRVKQDKILIY--HPAFIKYVFDNWLQGHGRY-----PSTGILSVIFSMHV 280
Cdd:cd23985  126 PYHSDIPEWYKN--PDYNFFENY----KTYRRLNPNQPFYilHPQMQWELWDIIQENSPEEiqpnpPSSGMLGIILMMTL 199


                 ....*....
gi 578816110 281 CDEVDLYGF 289
Cdd:cd23985  200 CDQVDVYEF 208
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 118-316 7.41e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 87.89  E-value: 7.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 118 KELFRVVPGNvDPMlekRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAG-FEADVGTKTthHLVYPesfr 196
Cdd:cd23991   47 ENIFRMFPKS-QPF---RGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKT--NLVTA---- 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 197 elgdNVSMILVPFKTIDLEWVVSAITTGTISHTYIPVPA------------------KIRVKQdKILIYHPAFIKYVFDN 258
Cdd:cd23991  117 ----NPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAfsyrsntalsfkvyytleDFKAKQ-KVIFFHPIYLKHLAQF 191

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578816110 259 WL-QGHGRYP-STGILSVIFSMHVCDEVDLYGFGADSKGN-----WHHYWENNPSagafrKTGVH 316
Cdd:cd23991  192 WRsKGVQVYRlSTGLMITSAALELCEEVKLYGFWPFSKNTegkpiSHHYYDNQLP-----KPGFH 251
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 140-310 1.02e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 84.50  E-value: 1.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 140 RRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAP-TAGFEADVGTKTthHLVYPesfrelgdNVSMILVPFKTIDLEWVV 218
Cdd:cd23989   64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKT--QLVTA--------NPSIIDKRFQNLLWSRKS 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 219 SAITTGTISHTYIPVPA---------KIRVKQ--------DKILIYHPAFIKYVFDNWLQG--HGRYPSTGILSVIFSMH 279
Cdd:cd23989  134 FVESMKVYGRSYIYMPAfsmktgtdpSLRVYYtladvganQTVLFANPNFLRNVGKFWKSKgvHAKRLSTGLFLVSAALG 213

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 578816110 280 VCDEVDLYGF-----GADSKGNWHHYWENNPSAGAF 310
Cdd:cd23989  214 LCEEVTIYGFwpfsvDLDERTISHHYYDNVLPDSGF 249
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 103-303 8.64e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 79.11  E-value: 8.64e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 103 RLQREKKPNNLNDTIKELFRVVPgnvDPMLEKRSvGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAP-TAGFEADV 181
Cdd:cd23990   32 KLKYEVDTSGIYHINSEIFKMFP---KDMPYSRS-QFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 182 GTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVVSAITTGTISHTYiPVPAKIRVK--------QDKILIYHPAFIK 253
Cdd:cd23990  108 GVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTR-NTDVSIRVKyvlddfesQQAVYYFHPQYLL 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578816110 254 YVFDNWL-QG-HGRYPSTGILSVIFSMHVCDEVDLYGFGA---DSKGNW--HHYWEN 303
Cdd:cd23990  187 NVSRFWLrQGvRAKRISSGLMLVTAALELCEEVHLYGFWAfpmNPSGIFitHHYYDN 243
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 118-289 1.40e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 78.44  E-value: 1.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 118 KELFRVVPgNVDPMLEKRSvgcRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYP----E 193
Cdd:cd23987   47 QNLYELLP-RTSPLKNKHF---KTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPsvvqR 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 194 SFRELGD--------------NVSMILVPFKTID-----LEWVVSAITTGTIShtyipvpakIRVKQDKILIYHPafiky 254
Cdd:cd23987  123 AFEDLVNetwkekflqrlqslNGSILWIPAFMAKggeerVEWVNDLILKHHIN---------VRTAYPSLRLLHA----- 188

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 578816110 255 VFDNWLQG--HGRYPSTGILSVIFSMHVCDEVDLYGF 289
Cdd:cd23987  189 VRGYWLTNkvHIKRPTTGLLMYTLATRFCNRIHLYGF 225
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 138-289 2.03e-16

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 77.96  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 138 GCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTT-------------HHLVYPESFRELgdnvsm 204
Cdd:cd23986   48 GFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTiriinsqiltnpnHHFIDSSLYKDV------ 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 205 ILV-----PFKTIDLEWVVSA---ITTGTISHtyipvpaKIRVKQDKILIYHPAFIKYVFDnWLQGHGRY------PSTG 270
Cdd:cd23986  122 ILVawdpaPYSANLHKWYKKPdynLFTPYVQY-------RKRNPNQPFYILHPKFIWQLWD-IIQENTQEkiqpnpPSSG 193

                        170
                 ....*....|....*....
gi 578816110 271 ILSVIFSMHVCDEVDLYGF 289
Cdd:cd23986  194 FIGILIMMSMCREVHVYEY 212
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 139-302 1.49e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 71.89  E-value: 1.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPES-----------FRELGDNVSMILV 207
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSvplllknpdyfFKETNETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 208 PFKTIDLEWvvSAITTGTISHTYIPVP-AKIRVKQDKILIYHPA-FIKYVFDNWLQGhGRYPSTGILSVIFSMHVCDEVD 285
Cdd:cd23975   81 PFRNMRKDG--KGIVYNMLKKAVESYPqAKIYVTTEKRMSYCDTvFKKETGKDRVQS-GSYLSTGWFTLILAMDACYGIH 157

                        170       180
                 ....*....|....*....|....
gi 578816110 286 LYGFGADS-------KGNWHHYWE 302
Cdd:cd23975  158 VYGMINDTycktegyRKVPYHYYE 181
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 139-288 5.34e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 70.27  E-value: 5.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTT-----HHLVY-----PESFRELGDNVSMIL-- 206
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTlrvvaHSSVYrvlrrPQEFLNRTPETTLIFwg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 207 ------VPFKTIDLEWVVSAITTGTISHTYIPVPAKIRvkqdkiliyhpafikyVFDNWLQGH-GR-------YPSTGIL 272
Cdd:cd23978   81 ppnkmqKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMR----------------QFDDLFRGEtGRdrkkshsWLSTGWF 144

                        170
                 ....*....|....*.
gi 578816110 273 SVIFSMHVCDEVDLYG 288
Cdd:cd23978  145 TMVIAVELCDNVHVYG 160
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 139-288 8.46e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 58.34  E-value: 8.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 139 CRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMIL-VPFKTIDLEWV 217
Cdd:cd23976   15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELLnVSQGTVFIFWG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578816110 218 VSAITTG----------TISHTYIPVPAKIRVKQDKILIYHPAFIK------YVFDNWLqghgrypSTGILSVIFSMHVC 281
Cdd:cd23976   95 PSNYMRRdgkglvynnlQLMNQILPKLKVYTITRHKMLQFDELFKRetgkdrKISNTWL-------STGWFTMIIALELC 167


                 ....*..
gi 578816110 282 DEVDLYG 288
Cdd:cd23976  168 DRINVYG 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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