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Conserved domains on  [gi|578817083|ref|XP_006717028|]
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adenylate kinase 8 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 198-390 5.85e-56

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 182.82  E-value: 5.85e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 277
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 278 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 354
Cdd:cd01428   80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 578817083 355 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 390
Cdd:cd01428  156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
PLN02842 super family cl31938
nucleotide kinase
 31-178 5.10e-27

nucleotide kinase


The actual alignment was detected with superfamily member PLN02842:

Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 112.65  E-value: 5.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  31 ARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDP 110
Cdd:PLN02842  46 AKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDP 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578817083 111 QTGEIYHTTFdWPPES-EIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVF 178
Cdd:PLN02842 126 VTGKIYHIKN-FPPESeEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYSDIMVKIDGNRPKEVVF 193
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 198-390 5.85e-56

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 182.82  E-value: 5.85e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 277
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 278 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 354
Cdd:cd01428   80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 578817083 355 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 390
Cdd:cd01428  156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 198-398 4.43e-40

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 141.80  E-value: 4.43e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 277
Cdd:COG0563    2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-ANG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 278 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 349
Cdd:COG0563   81 FILDGFPRTVAQAEaldeLLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVcdkcGGELVQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578817083 350 PKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 398
Cdd:COG0563  161 ADDNEETVRKRLEVYHEQTAPLIDYYrkkGKLVEIDGEGSIEEVTADILAIL 212
PLN02842 PLN02842
nucleotide kinase
 203-396 1.02e-39

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 148.09  E-value: 1.02e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 203 GPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHG 282
Cdd:PLN02842   4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 283 VPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMD 362
Cdd:PLN02842  84 YPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIKARLITRPDDTEEKVKARLQ 163

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 578817083 363 LFYRNSADLEQLYGSAI-TLNGDQDPYTVFEYIES 396
Cdd:PLN02842 164 IYKKNAEAILSTYSDIMvKIDGNRPKEVVFEEISS 198
ADK pfam00406
Adenylate kinase;
201-375 1.96e-38

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 136.67  E-value: 1.96e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  201 LLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGWVL 280
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC-KNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  281 HGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTM----EIQARLLQNPKDA 353
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPgkddVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|..
gi 578817083  354 EEQVKLKMDLFYRNSADLEQLY 375
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYY 181
PLN02842 PLN02842
nucleotide kinase
 31-178 5.10e-27

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 112.65  E-value: 5.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  31 ARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDP 110
Cdd:PLN02842  46 AKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDP 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578817083 111 QTGEIYHTTFdWPPES-EIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVF 178
Cdd:PLN02842 126 VTGKIYHIKN-FPPESeEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYSDIMVKIDGNRPKEVVF 193
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 30-177 6.65e-24

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 6.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  30 EARRLYLQRKTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL---GITPRHVIVLSAPDTVLIERNLGK 106
Cdd:cd01428   47 KAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKGFILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGR 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578817083 107 RIDPQTGEIYHTTFDWPPESEIQNRlmvPEDisELETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDV 177
Cdd:cd01428  126 RICPVSGRVYHLGKDDVTGEPLSQR---SDD--NEETIKKRLEvYKEQTAPLIDYYKKkgKLVEIDGSGDIDEV 194
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 41-186 2.07e-23

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 96.92  E-value: 2.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083   41 VPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRI-QTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTT 119
Cdd:TIGR01351  58 VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALdALLEEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLK 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578817083  120 FDWPPESEIQN----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVFYQALTYVQ 186
Cdd:TIGR01351 138 FNPPKVPGCDDctgeLLVQREDDTE-EVVKKRLEvYKEQTEPLIDYYKKrgILVQIDGNGPIDEVWKRILEALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 41-178 6.48e-21

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 90.19  E-value: 6.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  41 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL----GITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 116
Cdd:COG0563   59 VPDEIVIGLVKERLAQPDC-ANGFILDGFPRTVAQAEALDELlaelGIKLDAVIELDVDDEELVERLSGRRVCPNCGATY 137

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578817083 117 HTTFDWPPESEI----QNRLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVF 178
Cdd:COG0563  138 HVKFNPPKVEGVcdkcGGELVQRADDNE-ETVRKRLEvYHEQTAPLIDYYRKkgKLVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
39-163 7.48e-18

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 7.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083   39 KTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQAL---RIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEI 115
Cdd:pfam00406  53 ELVPDEVVVGLVKERLEQNDC-KNGFLLDGFPRTVPQAEaleELLERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRS 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578817083  116 YHTTFDwPPESEIQN-----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK 163
Cdd:pfam00406 132 YHLEFN-PPKVPGKDdvtgePLVQRSDDNE-ETVKKRLEtYHKQTKPLIDYYKK 183
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 197-391 3.55e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 61.76  E-value: 3.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  197 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQK 276
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  277 GWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRidpvtgeryhlmykppptmEIQARLlqnpKDAEEQ 356
Cdd:TIGR01360  84 GFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRA-------------------ETSGRV----DDNEKT 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 578817083  357 VKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVF 391
Cdd:TIGR01360 141 IKKRLETYYKATEPVIAYYetkGKLRKINAEGTVDDVF 178
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 198-390 5.85e-56

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 182.82  E-value: 5.85e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 277
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 278 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 354
Cdd:cd01428   80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 578817083 355 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 390
Cdd:cd01428  156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 198-398 4.43e-40

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 141.80  E-value: 4.43e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 277
Cdd:COG0563    2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-ANG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 278 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 349
Cdd:COG0563   81 FILDGFPRTVAQAEaldeLLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVcdkcGGELVQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578817083 350 PKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 398
Cdd:COG0563  161 ADDNEETVRKRLEVYHEQTAPLIDYYrkkGKLVEIDGEGSIEEVTADILAIL 212
PLN02842 PLN02842
nucleotide kinase
 203-396 1.02e-39

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 148.09  E-value: 1.02e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 203 GPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHG 282
Cdd:PLN02842   4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 283 VPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMD 362
Cdd:PLN02842  84 YPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIKARLITRPDDTEEKVKARLQ 163

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 578817083 363 LFYRNSADLEQLYGSAI-TLNGDQDPYTVFEYIES 396
Cdd:PLN02842 164 IYKKNAEAILSTYSDIMvKIDGNRPKEVVFEEISS 198
ADK pfam00406
Adenylate kinase;
201-375 1.96e-38

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 136.67  E-value: 1.96e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  201 LLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGWVL 280
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC-KNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  281 HGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTM----EIQARLLQNPKDA 353
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPgkddVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|..
gi 578817083  354 EEQVKLKMDLFYRNSADLEQLY 375
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYY 181
adk PRK00279
adenylate kinase; Reviewed
 198-396 8.30e-32

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 119.87  E-value: 8.30e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 277
Cdd:PRK00279   2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDC-KNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 278 WVLHGVPRDLDQAHLLNR----LGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 349
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEmlkeLGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKcdvcGEELIQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578817083 350 PKDAEEQVKLKMDLFYRNSADLEQLYGSA---ITLNGDQDPYTVFEYIES 396
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKgklKKIDGTGSIDEVFADILK 210
PRK14530 PRK14530
adenylate kinase; Provisional
 197-398 3.30e-29

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 112.96  E-value: 3.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 197 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLK----EAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQD 272
Cdd:PRK14530   4 PRILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRankqMDISDMDTEYDTPGEYMDAGELVPDAVVNEIVEEALSDAD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 273 ciqkGWVLHGVPRDLDQAHLLNRLGyNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQ 348
Cdd:PRK14530  84 ----GFVLDGYPRNLEQAEYLESIT-DLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVcdecGGELIQ 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578817083 349 NPKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 398
Cdd:PRK14530 159 RDDDTEETVRERLDVFEENTEPVIEHYrdqGVLVEVDGEQTPDEVWADIQDAI 211
PLN02842 PLN02842
nucleotide kinase
 31-178 5.10e-27

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 112.65  E-value: 5.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  31 ARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDP 110
Cdd:PLN02842  46 AKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDP 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578817083 111 QTGEIYHTTFdWPPES-EIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVF 178
Cdd:PLN02842 126 VTGKIYHIKN-FPPESeEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYSDIMVKIDGNRPKEVVF 193
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 30-177 6.65e-24

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 6.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  30 EARRLYLQRKTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL---GITPRHVIVLSAPDTVLIERNLGK 106
Cdd:cd01428   47 KAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKGFILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGR 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578817083 107 RIDPQTGEIYHTTFDWPPESEIQNRlmvPEDisELETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDV 177
Cdd:cd01428  126 RICPVSGRVYHLGKDDVTGEPLSQR---SDD--NEETIKKRLEvYKEQTAPLIDYYKKkgKLVEIDGSGDIDEV 194
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 41-186 2.07e-23

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 96.92  E-value: 2.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083   41 VPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRI-QTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTT 119
Cdd:TIGR01351  58 VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALdALLEEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLK 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578817083  120 FDWPPESEIQN----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVFYQALTYVQ 186
Cdd:TIGR01351 138 FNPPKVPGCDDctgeLLVQREDDTE-EVVKKRLEvYKEQTEPLIDYYKKrgILVQIDGNGPIDEVWKRILEALK 210
adk PRK02496
adenylate kinase; Provisional
 198-398 1.71e-22

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 93.66  E-value: 1.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 277
Cdd:PRK02496   3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDA-ANG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 278 WVLHGVPRDLDQAHLLNRL----GYNPNRVFFLNVPFDSIMERLTLR-RIDpvtgeryhlmykppptmeiqarllqnpkD 352
Cdd:PRK02496  82 WILDGFPRKVTQAAFLDELlqeiGQSGERVVNLDVPDDVVVERLLARgRKD----------------------------D 133

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 578817083 353 AEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 398
Cdd:PRK02496 134 TEEVIRRRLEVYREQTAPLIDYYrdrQKLLTIDGNQSVEAVTTELKAAL 182
PLN02674 PLN02674
adenylate kinase
 171-368 2.34e-22

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 94.95  E-value: 2.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 171 DQPCVDVFYQALTYVQSNHRTNApftpRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFE 250
Cdd:PLN02674  10 DVPSVDLMTELLRRMKCSSKPDK----RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 251 KEMAVPDSLLMKVLSQRLDQQDCiQKGWVLHGVPRDLDQAH----LLNRLGYNPNRVffLNVPF-DSIM-ERLTLRRIDP 324
Cdd:PLN02674  86 KGELVSDDLVVGIIDEAMKKPSC-QKGFILDGFPRTVVQAQkldeMLAKQGAKIDKV--LNFAIdDAILeERITGRWIHP 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 578817083 325 VTGERYHLMYKPPPTMEIQ----ARLLQNPKDAEEQVKLKMDLFYRNS 368
Cdd:PLN02674 163 SSGRTYHTKFAPPKVPGVDdvtgEPLIQRKDDTAAVLKSRLEAFHKQT 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 41-178 6.48e-21

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 90.19  E-value: 6.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  41 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL----GITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 116
Cdd:COG0563   59 VPDEIVIGLVKERLAQPDC-ANGFILDGFPRTVAQAEALDELlaelGIKLDAVIELDVDDEELVERLSGRRVCPNCGATY 137

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578817083 117 HTTFDWPPESEI----QNRLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVF 178
Cdd:COG0563  138 HVKFNPPKVEGVcdkcGGELVQRADDNE-ETVRKRLEvYHEQTAPLIDYYRKkgKLVEIDGEGSIEEVT 205
adk PRK00279
adenylate kinase; Reviewed
 41-178 4.29e-18

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 82.12  E-value: 4.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  41 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQAL----RIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 116
Cdd:PRK00279  59 VPDEIVIGLVKERLAQPDC-KNGFLLDGFPRTIPQAEaldeMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTY 137

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578817083 117 HTTFDWPPESEIQNR----LMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVF 178
Cdd:PRK00279 138 HVKFNPPKVEGKCDVcgeeLIQRADDNE-ETVRKRLEvYHKQTAPLIDYYKKkgKLKKIDGTGSIDEVF 205
ADK pfam00406
Adenylate kinase;
39-163 7.48e-18

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 7.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083   39 KTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQAL---RIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEI 115
Cdd:pfam00406  53 ELVPDEVVVGLVKERLEQNDC-KNGFLLDGFPRTVPQAEaleELLERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRS 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578817083  116 YHTTFDwPPESEIQN-----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK 163
Cdd:pfam00406 132 YHLEFN-PPKVPGKDdvtgePLVQRSDDNE-ETVKKRLEtYHKQTKPLIDYYKK 183
PRK14528 PRK14528
adenylate kinase; Provisional
 198-322 4.66e-17

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 78.51  E-value: 4.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 277
Cdd:PRK14528   3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADC-KNG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 578817083 278 WVLHGVPRDLDQA----HLLNRLGYNPNRVFFLNVPFDSIMERLTLRRI 322
Cdd:PRK14528  82 FLLDGFPRTVEQAdaldALLKNEGKSIDKAINLEVPDGELLKRLLGRAE 130
PRK13808 PRK13808
adenylate kinase; Provisional
 198-296 2.72e-15

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 76.46  E-value: 2.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQkG 277
Cdd:PRK13808   2 RLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-G 80

                         90
                 ....*....|....*....
gi 578817083 278 WVLHGVPRDLDQAHLLNRL 296
Cdd:PRK13808  81 FILDGFPRTVPQAEALDAL 99
PRK14526 PRK14526
adenylate kinase; Provisional
 198-405 5.01e-15

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 73.35  E-value: 5.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 277
Cdd:PRK14526   2 KLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKN-NDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 278 WVLHGVPRDLDQAHLLNRLGYNPNRVFFLnVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQNPKDA 353
Cdd:PRK14526  81 FILDGFPRNINQAKALDKFLPNIKIINFL-IDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGIcdvcKGDLYQRKDDK 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578817083 354 EEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEyIESGIINPLPKK 405
Cdd:PRK14526 160 EESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDE-VKKKLIEIISKK 210
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 198-375 6.58e-15

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 73.68  E-value: 6.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQ-QDCIQK 276
Cdd:PTZ00088   8 KIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKvTDDCFK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 277 GWVLHGVPRDLDQAhllNRLGYNPNRVFFLNV--PFDSIMERLTLRRIDPVTGERYHLM------YKPPPTMEIQ----- 343
Cdd:PTZ00088  88 GFILDGFPRNLKQC---KELGKITNIDLFVNIylPRNILIKKLLGRRICNTCNRNFNIAhirsdpYDMPPILPPAdcegc 164

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 578817083 344 ---ARLLQNPKDAEEQVKLKMDLFYRNSADLEQLY 375
Cdd:PTZ00088 165 kgnPKLQKRSDDTEEIVAHRLNTYESTNSPIIQFF 199
PRK14527 PRK14527
adenylate kinase; Provisional
 199-398 7.17e-15

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 72.52  E-value: 7.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 199 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKgw 278
Cdd:PRK14527   9 VIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRV-- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 279 VLHGVPRDLDQAHLLNRL----GYNPNRVFFLNVPFDSIMERLTLRridpvtgeryhlmykppptmeiqARLLQNPKDAE 354
Cdd:PRK14527  87 IFDGFPRTLAQAEALDRLleelGARLLAVVLLEVPDEELIRRIVER-----------------------ARQEGRSDDNE 143

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 578817083 355 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 398
Cdd:PRK14527 144 ETVRRRQQVYREQTQPLVDYYearGHLKRVDGLGTPDEVYARILKAL 190
PRK14530 PRK14530
adenylate kinase; Provisional
 41-161 1.35e-12

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 66.35  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  41 VPSALLVQLIQERLAEEDcikqGWILDGIPETREQALRIQtlGITPRHVIV-LSAPDTVLIERNLGKRIDPQTGEIYHTT 119
Cdd:PRK14530  66 VPDAVVNEIVEEALSDAD----GFVLDGYPRNLEQAEYLE--SITDLDVVLyLDVSEEELVDRLTGRRVCPDCGANYHVE 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 578817083 120 FDWPPESEIQN----RLMVPEDISElETAQKLLE-YHRNIVRVIPSY 161
Cdd:PRK14530 140 FNQPEEEGVCDecggELIQRDDDTE-ETVRERLDvFEENTEPVIEHY 185
adk PRK02496
adenylate kinase; Provisional
 41-152 1.49e-12

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 65.54  E-value: 1.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  41 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQA----LRIQTLGITPRHVIVLSAPDTVLIERNLGK-RIDPQtgei 115
Cdd:PRK02496  60 VPDQLVLDLVQERLQQPDA-ANGWILDGFPRKVTQAafldELLQEIGQSGERVVNLDVPDDVVVERLLARgRKDDT---- 134

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 578817083 116 yhttfdwppESEIQNRLMVPEDiselETAqKLLEYHR 152
Cdd:PRK02496 135 ---------EEVIRRRLEVYRE----QTA-PLIDYYR 157
AAA_17 pfam13207
AAA domain;
202-321 6.66e-12

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 62.64  E-value: 6.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  202 LGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTtfGELIQPFFEKEMAVPDSLLMKVLSQRLDqQDCIQKGWVLH 281
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIA-EEAGEGGVIVD 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 578817083  282 GVPRDLDQAHLLNRL------GYNPNRVFFLNVPFDSIMERLTLRR 321
Cdd:pfam13207  78 GHPRIKTPAGYLPGLpvevlrELKPDAIILLEADPEEILERRLKDR 123
PRK14529 PRK14529
adenylate kinase; Provisional
 198-293 3.12e-11

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 62.81  E-value: 3.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDciQKG 277
Cdd:PRK14529   2 NILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDG--KNG 79

                         90
                 ....*....|....*.
gi 578817083 278 WVLHGVPRDLDQAHLL 293
Cdd:PRK14529  80 WLLDGFPRNKVQAEKL 95
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 197-391 3.55e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 61.76  E-value: 3.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  197 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQK 276
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  277 GWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRidpvtgeryhlmykppptmEIQARLlqnpKDAEEQ 356
Cdd:TIGR01360  84 GFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRA-------------------ETSGRV----DDNEKT 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 578817083  357 VKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVF 391
Cdd:TIGR01360 141 IKKRLETYYKATEPVIAYYetkGKLRKINAEGTVDDVF 178
PRK14531 PRK14531
adenylate kinase; Provisional
 198-320 4.06e-11

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 61.37  E-value: 4.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 198 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLdqQDCIQKG 277
Cdd:PRK14531   4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALNSGG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 578817083 278 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLR 320
Cdd:PRK14531  82 WLLDGFPRTVAQAEalepLLEELKQPIEAVVLLELDDAVLIERLLAR 128
PRK14532 PRK14532
adenylate kinase; Provisional
 199-375 7.88e-11

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 60.99  E-value: 7.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 199 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGW 278
Cdd:PRK14532   3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEA-AGGA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083 279 VLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRridpvtgeryhlmykppptMEIQARllqnPKDAE 354
Cdd:PRK14532  82 IFDGFPRTVAQAEaldkMLASRGQKIDVVIRLKVDDEALIERIVKR-------------------FEEQGR----PDDNP 138

                        170       180
                 ....*....|....*....|.
gi 578817083 355 EQVKLKMDLFYRNSADLEQLY 375
Cdd:PRK14532 139 EVFVTRLDAYNAQTAPLLPYY 159
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 199-320 1.68e-09

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 57.00  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  199 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADR-TTFGELIQPFFEKEMAVPDSLLMKVLSQRLdQQDCIQKG 277
Cdd:TIGR01359   2 VFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAI-QEDGSSKK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 578817083  278 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLR 320
Cdd:TIGR01359  81 FLIDGFPRNEENLEAWEKLmdnKVNFKFVLFFDCPEETMIKRLLKR 126
PRK14528 PRK14528
adenylate kinase; Provisional
 30-108 4.57e-09

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 55.79  E-value: 4.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  30 EARRLYLQRKTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALR----IQTLGITPRHVIVLSAPDTVLIERNLG 105
Cdd:PRK14528  49 EAKRYMDAGDLVPDSVVIGIIKDRIREADC-KNGFLLDGFPRTVEQADAldalLKNEGKSIDKAINLEVPDGELLKRLLG 127


                 ...
gi 578817083 106 KRI 108
Cdd:PRK14528 128 RAE 130
PLN02674 PLN02674
adenylate kinase
 41-177 1.53e-08

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 54.89  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  41 VPSALLVQLIQERLAEEDCIKqGWILDGIPETREQALRIQTL----GITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 116
Cdd:PLN02674  90 VSDDLVVGIIDEAMKKPSCQK-GFILDGFPRTVVQAQKLDEMlakqGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTY 168

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817083 117 HTTFDwPP----------ESEIQNRlmvpEDISELeTAQKLLEYHRNIVRVIPSYPK--ILKVISADQPCVDV 177
Cdd:PLN02674 169 HTKFA-PPkvpgvddvtgEPLIQRK----DDTAAV-LKSRLEAFHKQTEPVIDYYAKkgVVANLHAEKPPKEV 235
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 4-124 1.88e-05

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 45.56  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083   4 WLCKHLNSSlltleNLILNEFSYTAT---EARRLYLQRKTVPSALLVQLIQERLAE-EDCIKQGWILDGIPETREQALRI 79
Cdd:PTZ00088  30 ENLKHINMG-----NILREEIKAKTTigkEIQKVVTSGNLVPDNLVIAIVKDEIAKvTDDCFKGFILDGFPRNLKQCKEL 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578817083  80 QTLgITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYH------TTFDWPP 124
Cdd:PTZ00088 105 GKI-TNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNiahirsDPYDMPP 154
PRK14527 PRK14527
adenylate kinase; Provisional
 41-106 4.52e-05

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 44.01  E-value: 4.52e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817083  41 VPSALLVQLIQERLAEEDCIKQgwILDGIPETREQA----LRIQTLGITPRHVIVLSAPDTVLIERNLGK 106
Cdd:PRK14527  65 VPDELILALIRDELAGMEPVRV--IFDGFPRTLAQAealdRLLEELGARLLAVVLLEVPDEELIRRIVER 132
AAA_17 pfam13207
AAA domain;
41-107 9.97e-05

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 41.84  E-value: 9.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817083   41 VPSALLVQLIQERLAEEdCIKQGWILDGIPETREQALRIQTL------GITPRHVIVLSAPDTVLIERNLGKR 107
Cdd:pfam13207  52 EPQKELQKLAAERIAEE-AGEGGVIVDGHPRIKTPAGYLPGLpvevlrELKPDAIILLEADPEEILERRLKDR 123
PRK14529 PRK14529
adenylate kinase; Provisional
 41-108 1.42e-03

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 39.70  E-value: 1.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578817083  41 VPSALLVQLIQERLAEEDciKQGWILDGIPETREQALR----IQTLGITPRHVIVLSAPDTVLIERNLGKRI 108
Cdd:PRK14529  59 VPDDITIPMILETLKQDG--KNGWLLDGFPRNKVQAEKlweaLQKEGMKLDYVIEILLPREVAKNRIMGRRL 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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