NCBI Conserved Domain Search

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

552-814

1.80e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 94.62 E-value: 1.80e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  552 LQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQE 631
Cdd:COG1196   237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  632 TSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLL 711
Cdd:COG1196   317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAA 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  712 KKtrvstdQAAAEQLSLVQAELQTQWEAkcehlLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQN 791
Cdd:COG1196   397 EL------AAQLEELEEAEEALLERLER-----LEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELL 465

                         250       260
                  ....*....|....*....|...
gi 578817221  792 EQHIKELEKNKSQMSGVEAAASD 814
Cdd:COG1196   466 AELLEEAALLEAALAELLEELAE 488

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

510-826

1.33e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 92.04 E-value: 1.33e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   510 KQEILEKSNRIEEQNDKISEL-IERNQRYVEQSNLMMEKRnnSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQ 588
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELeKALAELRKELEELEEELE--QLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLS 753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   589 LKMTAHQKKETELQMQLTEslketdlLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEK 668
Cdd:TIGR02168  754 KELTELEAEIEELEERLEE-------AEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   669 ESLEKNLsERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTrvstdQAAAEQLSLVQAELQTQWEAKCEHL--LA 746
Cdd:TIGR02168  827 ESLERRI-AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEEL-----ESELEALLNERASLEEALALLRSELeeLS 900

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   747 SAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQ-NEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 825
Cdd:TIGR02168  901 EELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERlSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENK 980


                   .
gi 578817221   826 V 826
Cdd:TIGR02168  981 I 981

PRK03918

DNA double-strand break repair ATPase Rad50;

495-834

9.41e-12

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 69.71 E-value: 9.41e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRI-----IQENERLKQEILEKSNRIEEQNDKISELIERNQRyveqsnlmMEKRNNSLQTATENTQA-------- 561
Cdd:PRK03918  370 KKEELERLkkrltGLTPEKLEKELEELEKAKEEIEEEISKITARIGE--------LKKEIKELKKAIEELKKakgkcpvc 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  562 -RVLHAEQEK---AKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTE-----SLKET-DLLRG--------QLTKVQ 623
Cdd:PRK03918  442 gRELTEEHRKellEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKeseliKLKELaEQLKEleeklkkyNLEELE 521

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  624 AKLSELQETSEQA------QSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQErsqAEEEIDEIR 697
Cdd:PRK03918  522 KKAEEYEKLKEKLiklkgeIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEE---LEERLKELE 598

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  698 KSYQE---------ELDKLRQLLKKTRVSTDQAAAEqLSLVQAELQtQWEAKCEHLLASAKDEhlqQYQEVcaqrdayQQ 768
Cdd:PRK03918  599 PFYNEylelkdaekELEREEKELKKLEEELDKAFEE-LAETEKRLE-ELRKELEELEKKYSEE---EYEEL-------RE 666

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221  769 KLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDpSEKVKKIMNQVfQSLRREF 834
Cdd:PRK03918  667 EYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKE-LEKLEKALERV-EELREKV 730

SCP-1

pfam05483

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...

441-839

1.74e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.

Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 65.51 E-value: 1.74e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   441 MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMET--SMIMSNIQRIIQENERLK---QEILE 515
Cdd:pfam05483  309 MSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSleELLRTEQQRLEKNEDQLKiitMELQK 388

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   516 KSNRIEE----QNDKISELIERNQRYVEQSNLMMEKRNnsLQTATENTQARvlhaEQEkakVTEELAAATAQVSHLQLKM 591
Cdd:pfam05483  389 KSSELEEmtkfKNNKEVELEELKKILAEDEKLLDEKKQ--FEKIAEELKGK----EQE---LIFLLQAREKEIHDLEIQL 459

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   592 TA-------HQKKETELQMQL-TESLKETDLL---------RGQLTKVQAKLS-ELQETSEQAQSKFKSEKQNRKQLElk 653
Cdd:pfam05483  460 TAiktseehYLKEVEDLKTELeKEKLKNIELTahcdkllleNKELTQEASDMTlELKKHQEDIINCKKQEERMLKQIE-- 537

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   654 vtSLEEELTDLRVEKESLEKNLSERK-------KKSAQERSQAEEEI--------------DEIRKSYQEELDKLRQLLK 712
Cdd:pfam05483  538 --NLEEKEMNLRDELESVREEFIQKGdevkcklDKSEENARSIEYEVlkkekqmkilenkcNNLKKQIENKNKNIEELHQ 615

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   713 KTRVSTDQAAAEQLSLVQAELQTQweaKCEHLLASAK---DEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 789
Cdd:pfam05483  616 ENKALKKKGSAENKQLNAYEIKVN---KLELELASAKqkfEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQK 692

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578817221   790 QNE---QH-----IKELEKNKSQMSGVeAAASDPSEKVKKIMNQVFQSLRREFELEES 839
Cdd:pfam05483  693 EIDkrcQHkiaemVALMEKHKHQYDKI-IEERDSELGLYKNKEQEQSSAKAALEIELS 749

PRK10902

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional

123-241

1.34e-09

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional

Pssm-ID: 236791 [Multi-domain] Cd Length: 269 Bit Score: 60.55 E-value: 1.34e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  123 GPAVEVGDSLEVAYTGWLfqnhVLGQVFDSTANKDKLLRLKLGSgkVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVI 202
Cdd:PRK10902  158 GEAPKDSDTVVVNYKGTL----IDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVP 231

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 578817221  203 GWtqATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAA 241
Cdd:PRK10902  232 GI--PANSTLVFDVELLDVKPAPKADAKPEADAKAADSA 268

PHA03247

large tegument protein UL36; Provisional

883-1096

6.64e-06

large tegument protein UL36; Provisional

Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.71 E-value: 6.64e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  883 RPRRPSQEQsasassgQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGhrRKGDSEAEALSEIKDGSLPPELS 962
Cdd:PHA03247 2907 RPPQPQAPP-------PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE--PSGAVPQPWLGALVPGRVAVPRF 2977

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  963 CIPSHRvlgPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVRE-VAPDGPLQESSTRLSLTSDPEEGDPLA 1041
Cdd:PHA03247 2978 RVPQPA---PSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtLWPPDDTEDSDADSLFDSDSERSDLEA 3054

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578817221 1042 LGPEsPGEPQPPQLKKDDVTSSTGPHKELSSTEAG--STVAGAAL--RPSHHSQRSSLS 1096
Cdd:PHA03247 3055 LDPL-PPEPHDPFAHEPDPATPEAGARESPSSQFGppPLSANAALsrRYVRSTGRSALA 3112

Atrophin-1

pfam03154

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...

239-427

3.41e-04

Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.76 E-value: 3.41e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   239 SAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSnslseqlAINTSPDAVKAKLISRMAKMgQPMLPILPPQldsn 318
Cdd:pfam03154  192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHT-------LIQQTPTLHPQRLPSPHPPL-QPMTQPPPPS---- 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   319 dseiedvntlqgggQPVVTPSVQPSLHPAHPALPQMTSQAPqpsvTGLQAPSAAL-MQVSSLDSHSAVSGNAQSFQPYAG 397
Cdd:pfam03154  260 --------------QVSPQPLPQPSLHGQMPPMPHSLQTGP----SHMQHPVPPQpFPLTPQSSQSQVPPGPSPAAPGQS 321

                          170       180       190
                   ....*....|....*....|....*....|..
gi 578817221   398 MQAYAYPQASAVTSQLQPVR--PLYPAPLSQP 427
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQPPReqPLPPAPLSMP 353

AmmeMemoSam_B

TIGR04336

AmmeMemoRadiSam system protein B; Members of this protein family belong to the same domain ...

946-1004

9.34e-04

AmmeMemoRadiSam system protein B; Members of this protein family belong to the same domain family as the mammalian protein Memo (Mediator of ErbB2-driven cell MOtility). Members of the present family occur as part of a three gene system with an uncharacterized radical SAM enzyme and a homolog of the mammalian protein AMMECR1, a mammalian protein named for AMME - Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis. Memo in humans has protein-protein interaction activity with binding of phosphorylated Try, but members of this family may be active as enzymes, as suggested by homology to a class of nonheme iron dioxygenases.

Pssm-ID: 275135 [Multi-domain] Cd Length: 269 Bit Score: 42.56 E-value: 9.34e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221   946 AEALSEIKDGslPPELSCI--PSHRVLGPPTSIPPE-----PLGPVSMDSECEESLAASPMAAKPD 1004
Cdd:TIGR04336   55 AHAYAALKKG--RPETVVLlgPNHTGYGSGIALPPEgswetPLGDVPVDEELAEELLEHSPIIELD 118

ClyA_Cry6Aa-like

cd22656

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...

587-739

1.36e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.

Pssm-ID: 439154 [Multi-domain] Cd Length: 309 Bit Score: 42.36 E-value: 1.36e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  587 LQLKMTAHQKKETELQMQLTESLKE-TDLLRGQLTKVQAKLSELQEtseqAQSKFKSE-KQNRKQLELKVTSLEEELTD- 663
Cdd:cd22656    97 LELIDDLADATDDEELEEAKKTIKAlLDDLLKEAKKYQDKAAKVVD----KLTDFENQtEKDQTALETLEKALKDLLTDe 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  664 -LRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRqllKKTRVSTD-QAAAEQLSLVQA---------- 731
Cdd:cd22656   173 gGAIARKEIKDLQKELEKLNEEYAAKLKAKIDELKALIADDEAKLA---AALRLIADlTAADTDLDNLLAligpaipale 249


                  ....*...
gi 578817221  732 ELQTQWEA 739
Cdd:cd22656   250 KLQGAWQA 257

growth_prot_Scy

NF041483

polarized growth protein Scy;

552-835

1.42e-03

polarized growth protein Scy;

Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 42.89 E-value: 1.42e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  552 LQTATENTQARVLHAEQEKAKVTEELAAATAQVShlQLKMTAHQKKeTELQMQLTESLKETDLLRGQLTKVQAK-LSELQ 630
Cdd:NF041483  224 LNAASTQAQEATDHAEQLRSSTAAESDQARRQAA--ELSRAAEQRM-QEAEEALREARAEAEKVVAEAKEAAAKqLASAE 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  631 ETSEQAQSKFKSE-----KQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAeeEIDEIRKSYQEELD 705
Cdd:NF041483  301 SANEQRTRTAKEEiarlvGEATKEAEALKAEAEQALADARAEAEKLVAEAAEKARTVAAEDTAA--QLAKAARTAEEVLT 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  706 KLRQLLKktrvSTDQAAAEQLSLVQAELqtqwEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQIT 785
Cdd:NF041483  379 KASEDAK----ATTRAAAEEAERIRREA----EAEADRLRGEAADQAEQLKGAAKDDTKEYRAKTVELQEEARRLRGEAE 450

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817221  786 AL---------------TKQNEQHIKE--------LEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFE 835
Cdd:NF041483  451 QLraeavaegerirgeaRREAVQQIEEaartaeelLTKAKADADELRSTATAESERVRTEAIERATTLRRQAE 523

PspC_subgroup_1

NF033838

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...

495-713

1.69e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.

Pssm-ID: 468201 [Multi-domain] Cd Length: 684 Bit Score: 42.69 E-value: 1.69e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRIIQEnerlKQEILEKSNRIeeQN-DKISELIERNQRYVEQSNLMMEKRNNSLQTAT-ENTQARVLHAEQEKAK 572
Cdd:NF033838   63 VESHLEKILSE----IQKSLDKRKHT--QNvALNKKLSDIKTEYLYELNVLKEKSEAELTSKTkKELDAAFEQFKKDTLE 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  573 VTEELAAATAQVSHLQLKmtAHQKKETELQMQLTESLKETDLLRGQlTKVQAKLSELQETSEQAQSKFKSEKQnrKQLEL 652
Cdd:NF033838  137 PGKKVAEATKKVEEAEKK--AKDQKEEDRRNYPTNTYKTLELEIAE-SDVEVKKAELELVKEEAKEPRDEEKI--KQAKA 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817221  653 KVTSLEEELTdlrvekeSLEKNLSERKK--KSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK 713
Cdd:NF033838  212 KVESKKAEAT-------RLEKIKTDREKaeEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKR 267

PRK10263

DNA translocase FtsK; Provisional

329-423

1.83e-03

DNA translocase FtsK; Provisional

Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.76 E-value: 1.83e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  329 QGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQA------PSAALMQVSSLDSHSAVSGN-AQSFQPYAGMQAY 401
Cdd:PRK10263  738 DGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQyqqpqqPVAPQPQYQQPQQPVAPQPQyQQPQQPVAPQPQY 817

                          90       100
                  ....*....|....*....|....
gi 578817221  402 AYPQASAVTSQ--LQPVRPLYPAP 423
Cdd:PRK10263  818 QQPQQPVAPQPqyQQPQQPVAPQP 841

WH1

smart00461

WASP homology region 1; Region of the Wiskott-Aldrich syndrome protein (WASp) that contains ...

2-100

1.86e-03

WASP homology region 1; Region of the Wiskott-Aldrich syndrome protein (WASp) that contains point mutations in the majority of patients with WAS. Unknown function. Ena-like WH1 domains bind polyproline-containing peptides, and that Homer contains a WH1 domain.

Pssm-ID: 214674 Cd Length: 106 Bit Score: 38.88 E-value: 1.86e-03

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221      2 STPTILVATAVHAYRYTNGQYVKQGKFGAAVLG---NHTAREYRILLYISQQQPVTVARIHVNFELMVRPNNYSTFYDDQ 78
Cdd:smart00461    3 SQCIILARAVVQLYDADTKKWVPTGEGGAANLVidkNQRSYFFRIVGIKGQDKVIWNQELYKNFKYNQATPTFHQWADDK 82

                            90       100
                    ....*....|....*....|..
gi 578817221     79 RQnWSIMFESEKAAVEFNKQVC 100
Cdd:smart00461   83 CV-YGLNFASEEEAKKFRKKVL 103

tig

TIGR00115

trigger factor; Trigger factor is a ribosome-associated molecular chaperone and is the first ...

110-183

2.17e-03

trigger factor; Trigger factor is a ribosome-associated molecular chaperone and is the first chaperone to interact with nascent polypeptide. Trigger factor can bind at the same time as the signal recognition particle (SRP), but is excluded by the SRP receptor (FtsY). The central domain of trigger factor has peptidyl-prolyl cis/trans isomerase activity. This protein is found in a single copy in virtually every bacterial genome. [Protein fate, Protein folding and stabilization]

Pssm-ID: 272913 [Multi-domain] Cd Length: 410 Bit Score: 41.77 E-value: 2.17e-03

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221   110 LDAVLSQ--DLIVADGPAVEVGDSLEVAYTGwlfqnHVLGQVFDSTANKDklLRLKLGSGKVIKGWEDGMLGMKKG 183
Cdd:TIGR00115  131 LERLREQnaTLVPVERGAAEKGDRVTIDFEG-----FIDGEAFEGGKAEN--FSLELGSGQFIPGFEEQLVGMKAG 199

Name

Accession

Description

Interval

E-value

FKBP_C

pfam00254

FKBP-type peptidyl-prolyl cis-trans isomerase;

125-218

1.10e-29

FKBP-type peptidyl-prolyl cis-trans isomerase;

Pssm-ID: 459735 Cd Length: 94 Bit Score: 113.45 E-value: 1.10e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   125 AVEVGDSLEVAYTGWLFQnhvlGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVIGW 204
Cdd:pfam00254    4 KAKKGDRVTVHYTGTLED----GTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGP 79

                           90
                   ....*....|....
gi 578817221   205 TQATDSILVFEVEV 218
Cdd:pfam00254   80 VIPPNATLVFEVEL 93

FkpA

COG0545

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...

116-218

1.84e-26

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440311 [Multi-domain] Cd Length: 104 Bit Score: 104.49 E-value: 1.84e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  116 QDLIVADGPAVEVGDSLEVAYTGWLFQnhvlGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACA 195
Cdd:COG0545     4 KVLKEGTGAKPKAGDTVTVHYTGTLLD----GTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELA 79

                          90       100
                  ....*....|....*....|....*.
gi 578817221  196 VGSEG---VIGwtqaTDSILVFEVEV 218
Cdd:COG0545    80 YGERGaggVIP----PNSTLVFEVEL 101

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

552-814

1.80e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 94.62 E-value: 1.80e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  552 LQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQE 631
Cdd:COG1196   237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  632 TSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLL 711
Cdd:COG1196   317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAA 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  712 KKtrvstdQAAAEQLSLVQAELQTQWEAkcehlLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQN 791
Cdd:COG1196   397 EL------AAQLEELEEAEEALLERLER-----LEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELL 465

                         250       260
                  ....*....|....*....|...
gi 578817221  792 EQHIKELEKNKSQMSGVEAAASD 814
Cdd:COG1196   466 AELLEEAALLEAALAELLEELAE 488

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

510-826

1.33e-18

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 92.04 E-value: 1.33e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   510 KQEILEKSNRIEEQNDKISEL-IERNQRYVEQSNLMMEKRnnSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQ 588
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELeKALAELRKELEELEEELE--QLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLS 753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   589 LKMTAHQKKETELQMQLTEslketdlLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEK 668
Cdd:TIGR02168  754 KELTELEAEIEELEERLEE-------AEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   669 ESLEKNLsERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTrvstdQAAAEQLSLVQAELQTQWEAKCEHL--LA 746
Cdd:TIGR02168  827 ESLERRI-AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEEL-----ESELEALLNERASLEEALALLRSELeeLS 900

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   747 SAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQ-NEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 825
Cdd:TIGR02168  901 EELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERlSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENK 980


                   .
gi 578817221   826 V 826
Cdd:TIGR02168  981 I 981

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

495-736

3.46e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 90.77 E-value: 3.46e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNS------LQTATENTQARVLHAEQ 568
Cdd:COG1196   258 LEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELeerleeLEEELAELEEELEELEE 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  569 EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRK 648
Cdd:COG1196   338 ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLE 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  649 QLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSyQEELDKLRQLLKKTRVSTDQAAAEQLSL 728
Cdd:COG1196   418 RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAEL-LEEAALLEAALAELLEELAEAAARLLLL 496


                  ....*...
gi 578817221  729 VQAELQTQ 736
Cdd:COG1196   497 LEAEADYE 504

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

504-814

9.62e-18

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 89.35 E-value: 9.62e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   504 QEN-ERLkQEILeksNRIEEQNDKISELIERNQRYVEQSNlmmEKRN----------NSLQTATENTQARVLHAEQEKAK 572
Cdd:TIGR02168  185 RENlDRL-EDIL---NELERQLKSLERQAEKAERYKELKA---ELRElelallvlrlEELREELEELQEELKEAEEELEE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   573 VTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL 652
Cdd:TIGR02168  258 LTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAE 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   653 KVTSLEEELTDLRVEKESLEKNLSERKKKS-----------------AQERSQAEEEIDEIRKSYQEELDKLRQL---LK 712
Cdd:TIGR02168  338 ELAELEEKLEELKEELESLEAELEELEAELeelesrleeleeqletlRSKVAQLELQIASLNNEIERLEARLERLedrRE 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   713 KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHL--LASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQ 790
Cdd:TIGR02168  418 RLQQEIEELLKKLEEAELKELQAELEELEEELeeLQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERL 497

                          330       340       350
                   ....*....|....*....|....*....|
gi 578817221   791 NEQH------IKELEKNKSQMSGVEAAASD 814
Cdd:TIGR02168  498 QENLegfsegVKALLKNQSGLSGILGVLSE 527

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

492-819

7.73e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 86.28 E-value: 7.73e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   492 TSMI-MSNIQR--IIQE----------NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSN-------LMMEKRN-- 549
Cdd:TIGR02169  145 TDFIsMSPVERrkIIDEiagvaefdrkKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREkaeryqaLLKEKREye 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   550 --------NSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETEL----QMQLTESLKEtdlLRG 617
Cdd:TIGR02169  225 gyellkekEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLgeeeQLRVKEKIGE---LEA 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   618 QLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIR 697
Cdd:TIGR02169  302 EIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFA 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   698 ------KSYQEELDKLRQLLK--KTRVSTDQAAAEQLSLVQAELQTQweakcehlLASAKDEHLQQYQEVCAQRD---AY 766
Cdd:TIGR02169  382 etrdelKDYREKLEKLKREINelKRELDRLQEELQRLSEELADLNAA--------IAGIEAKINELEEEKEDKALeikKQ 453

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 578817221   767 QQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKV 819
Cdd:TIGR02169  454 EWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERV 506

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

501-790

1.21e-16

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 85.50 E-value: 1.21e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   501 RIIQENERLKQEILEKSNRIEEQNDKISELIERNQryveqsnlMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAA 580
Cdd:TIGR02169  692 SLQSELRRIENRLDELSQELSDASRKIGEIEKEIE--------QLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKEL 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   581 TAQVSHLQLKMTAHQKKETELQMQLTESL------------KETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRK 648
Cdd:TIGR02169  764 EARIEELEEDLHKLEEALNDLEARLSHSRipeiqaelskleEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRI 843

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   649 QLELKVTSLEEELTDLRVEKESLE----------KNLSERKKKSAQERSQAEEEIDEIRKSYQE---ELDKLRQLLKKTR 715
Cdd:TIGR02169  844 DLKEQIKSIEKEIENLNGKKEELEeeleeleaalRDLESRLGDLKKERDELEAQLRELERKIEEleaQIEKKRKRLSELK 923

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   716 VsTDQAAAEQLS----------------LVQAELQTQWEAKCEHL--LASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKC 777
Cdd:TIGR02169  924 A-KLEALEEELSeiedpkgedeeipeeeLSLEDVQAELQRVEEEIraLEPVNMLAIQEYEEVLKRLDELKEKRAKLEEER 1002

                          330
                   ....*....|...
gi 578817221   778 LALQAQITALTKQ 790
Cdd:TIGR02169 1003 KAILERIEEYEKK 1015

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

498-834

1.23e-16

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 85.49 E-value: 1.23e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   498 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMmEKRNNSLQTATENTQARVLHAEQEKAKVTEEL 577
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAL-RKDLARLEAEVEQLEERIAQLSKELTELEAEI 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   578 AAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSL 657
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDL 843

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   658 EEELTDLRVEKESLEKNLSE----RKKKSAQ------ERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLS 727
Cdd:TIGR02168  844 EEQIEELSEDIESLAAEIEEleelIEELESEleallnERASLEEALALLRSELEELSEELRELESKRSELRRELEELREK 923

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   728 LVQAELQ-TQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMS 806
Cdd:TIGR02168  924 LAQLELRlEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKERYD 1003

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 578817221   807 GVEAAASDPSEKVKKIM--------------NQVFQSLRREF 834
Cdd:TIGR02168 1004 FLTAQKEDLTEAKETLEeaieeidrearerfKDTFDQVNENF 1045

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

499-759

6.39e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 83.06 E-value: 6.39e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  499 IQRIIQENERLKQEILEKSNRIEEQNDKISEL---IERNQRYVEQSNLMMEKRNNSLQTAT----------ENTQARVLH 565
Cdd:COG1196   234 LRELEAELEELEAELEELEAELEELEAELAELeaeLEELRLELEELELELEEAQAEEYELLaelarleqdiARLEERRRE 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  566 AEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQ 645
Cdd:COG1196   314 LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR 393

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  646 NRKQLELKVTSLEEELTDLRVEKESLEKNLSERK---KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA 722
Cdd:COG1196   394 AAAELAAQLEELEEAEEALLERLERLEEELEELEealAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA 473

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 578817221  723 AEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEV 759
Cdd:COG1196   474 LLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGV 510

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

555-838

8.94e-15

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 79.72 E-value: 8.94e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   555 ATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSE 634
Cdd:TIGR02168  664 GSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE 743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   635 QAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN---LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLL 711
Cdd:TIGR02168  744 QLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEieeLEAQIEQLKEELKALREALDELRAELTLLNEEAANLR 823

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   712 KKTRVSTDQAAAEQLSLVqaELQTQWEAKCEHLLASAK---------DEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQA 782
Cdd:TIGR02168  824 ERLESLERRIAATERRLE--DLEEQIEELSEDIESLAAeieeleeliEELESELEALLNERASLEEALALLRSELEELSE 901

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221   783 QITALTKQNEQHIKELEKNKSQMSGVEAAAsdpsEKVKKIMNQVFQSLRREFELEE 838
Cdd:TIGR02168  902 ELRELESKRSELRRELEELREKLAQLELRL----EGLEVRIDNLQERLSEEYSLTL 953

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

573-838

1.86e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 78.44 E-value: 1.86e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  573 VTEELAAataQVSHLQ------LKMTAHQKKETELQMQLTesLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQN 646
Cdd:COG1196   194 ILGELER---QLEPLErqaekaERYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAE 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  647 RKQLELKVTSLEEELTDLRVEKESLEK---NLSERKKKSAQERSQAEEEIDEIrksyQEELDKLRQllkktRVSTDQAAA 723
Cdd:COG1196   269 LEELRLELEELELELEEAQAEEYELLAelaRLEQDIARLEERRRELEERLEEL----EEELAELEE-----ELEELEEEL 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  724 EQLSLVQAELQTQWEAKCEHL--LASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKN 801
Cdd:COG1196   340 EELEEELEEAEEELEEAEAELaeAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL 419

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 578817221  802 KSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEE 838
Cdd:COG1196   420 EEELEELEEALAELEEEEEEEEEALEEAAEEEAELEE 456

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

499-840

2.93e-13

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 74.72 E-value: 2.93e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   499 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERnqryVEQSNLMMEKRnnslqtatentqarvlhAEQEKAKVTEELA 578
Cdd:TIGR02169  239 KEAIERQLASLEEELEKLTEEISELEKRLEEIEQL----LEELNKKIKDL-----------------GEEEQLRVKEKIG 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   579 AATAQVSHLQlkmtaHQKKETELQMQLTEslketdllrGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLE 658
Cdd:TIGR02169  298 ELEAEIASLE-----RSIAEKERELEDAE---------ERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELK 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   659 EELTDLRVEKESLEKNLSERKKKSAQER---SQAEEEIDEIRKSYQEELDKLRQLlkKTRVSTDQAAAEQLSLVQAELQT 735
Cdd:TIGR02169  364 EELEDLRAELEEVDKEFAETRDELKDYReklEKLKREINELKRELDRLQEELQRL--SEELADLNAAIAGIEAKINELEE 441

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   736 QWEAKCEHLlasAKDEhlQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALtkqnEQHIKELEKNKSQMSGVEAAASDP 815
Cdd:TIGR02169  442 EKEDKALEI---KKQE--WKLEQLAADLSKYEQELYDLKEEYDRVEKELSKL----QRELAEAEAQARASEERVRGGRAV 512

                          330       340
                   ....*....|....*....|....*
gi 578817221   816 SEKVKKIMNQVFQSLRREFELEESY 840
Cdd:TIGR02169  513 EEVLKASIQGVHGTVAQLGSVGERY 537

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

558-798

5.11e-13

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 73.80 E-value: 5.11e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  558 NTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQM--QLTESLKETDLLRGQLTKVQAKLSELqetsEQ 635
Cdd:COG4913   607 DNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaEYSWDEIDVASAEREIAELEAELERL----DA 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  636 AQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTR 715
Cdd:COG4913   683 SSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDA 762

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  716 VStdQAAAEQLSLVQAELQTQwEAKCEHLLASAKDEHLQQYQEVCAQRDA-------YQQKLVQLQEKCL-ALQAQI-TA 786
Cdd:COG4913   763 VE--RELRENLEERIDALRAR-LNRAEEELERAMRAFNREWPAETADLDAdleslpeYLALLDRLEEDGLpEYEERFkEL 839

                         250
                  ....*....|..
gi 578817221  787 LTKQNEQHIKEL 798
Cdd:COG4913   840 LNENSIEFVADL 851

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

495-837

1.70e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 71.98 E-value: 1.70e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   495 IMSNIQRIIQENERLKQEILEksnrIEEQNDKISELIERNQryveqsnlmmeKRNNSLQTATENTQARVLHAEQEKAKVT 574
Cdd:TIGR04523  202 LLSNLKKKIQKNKSLESQISE----LKKQNNQLKDNIEKKQ-----------QEINEKTTEISNTQTQLNQLKDEQNKIK 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   575 EELAAATAQVSHLQLKMTAHQKKETELQMQLTE--SLKETDL---LRGQLTKVQAKLSELqetseqaQSKFKSEKQNRKQ 649
Cdd:TIGR04523  267 KQLSEKQKELEQNNKKIKELEKQLNQLKSEISDlnNQKEQDWnkeLKSELKNQEKKLEEI-------QNQISQNNKIISQ 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   650 LELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIrKSYQEELDKLRQLLKKtrvstdqaaAEQLSlv 729
Cdd:TIGR04523  340 LNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEI-KNLESQINDLESKIQN---------QEKLN-- 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   730 qAELQTQWEAkcehlLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITAL--------------------TK 789
Cdd:TIGR04523  408 -QQKDEQIKK-----LQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLdntresletqlkvlsrsinkIK 481

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 578817221   790 QN-EQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELE 837
Cdd:TIGR04523  482 QNlEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLE 530

YhaN

COG4717

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

500-834

3.20e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 70.95 E-value: 3.20e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  500 QRIIQENERLK------QEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKV 573
Cdd:COG4717   139 AELAELPERLEeleerlEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEA 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  574 TEELAAATAQVSHLQLKMTAHQKKETELQMQ--------------LTESLKETDLLRGQLTKVQAKL-----SELQETSE 634
Cdd:COG4717   219 QEELEELEEELEQLENELEAAALEERLKEARlllliaaallallgLGGSLLSLILTIAGVLFLVLGLlallfLLLAREKA 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  635 QAQSKFKSEKQNRKQLELKVTSLEEELTDLRVeKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEE--LDKLRQLLK 712
Cdd:COG4717   299 SLGKEAEELQALPALEELEEEELEELLAALGL-PPDLSPEELLELLDRIEELQELLREAEELEEELQLEelEQEIAALLA 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  713 KTRVSTD-------------QAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLA 779
Cdd:COG4717   378 EAGVEDEeelraaleqaeeyQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAE 457

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  780 LQAQITALTKQNE-----QHIKELEKNKSQMsgVEAAASDpsEKVKKIMNQVFQSLRREF 834
Cdd:COG4717   458 LEAELEQLEEDGElaellQELEELKAELREL--AEEWAAL--KLALELLEEAREEYREER 513

PRK03918

DNA double-strand break repair ATPase Rad50;

495-834

9.41e-12

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 69.71 E-value: 9.41e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRI-----IQENERLKQEILEKSNRIEEQNDKISELIERNQRyveqsnlmMEKRNNSLQTATENTQA-------- 561
Cdd:PRK03918  370 KKEELERLkkrltGLTPEKLEKELEELEKAKEEIEEEISKITARIGE--------LKKEIKELKKAIEELKKakgkcpvc 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  562 -RVLHAEQEK---AKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTE-----SLKET-DLLRG--------QLTKVQ 623
Cdd:PRK03918  442 gRELTEEHRKellEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKeseliKLKELaEQLKEleeklkkyNLEELE 521

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  624 AKLSELQETSEQA------QSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQErsqAEEEIDEIR 697
Cdd:PRK03918  522 KKAEEYEKLKEKLiklkgeIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEE---LEERLKELE 598

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  698 KSYQE---------ELDKLRQLLKKTRVSTDQAAAEqLSLVQAELQtQWEAKCEHLLASAKDEhlqQYQEVcaqrdayQQ 768
Cdd:PRK03918  599 PFYNEylelkdaekELEREEKELKKLEEELDKAFEE-LAETEKRLE-ELRKELEELEKKYSEE---EYEEL-------RE 666

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221  769 KLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDpSEKVKKIMNQVfQSLRREF 834
Cdd:PRK03918  667 EYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKE-LEKLEKALERV-EELREKV 730

HEC1

COG5185

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...

503-825

1.72e-11

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 444066 [Multi-domain] Cd Length: 594 Bit Score: 68.45 E-value: 1.72e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  503 IQENERLKQEILEKSNRIEEQNDKISELIERNQRYVE----QSNLMMEKRN---NSLQTATENTQARVLHAEQE--KAKV 573
Cdd:COG5185   231 IEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLeklgENAESSKRLNenaNNLIKQFENTKEKIAEYTKSidIKKA 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  574 TEE----LAAATAQVSHLQLKMtahqKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNrKQ 649
Cdd:COG5185   311 TESleeqLAAAEAEQELEESKR----ETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSSEELDSFK-DT 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  650 LELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK-KTRVSTDQAAAEQLSL 728
Cdd:COG5185   386 IESTKESLDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISeLNKVMREADEESQSRL 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  729 VQA------ELQTQWEAKCEHL------LASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKC-LALQAQITALTKQNEQHI 795
Cdd:COG5185   466 EEAydeinrSVRSKKEDLNEELtqiesrVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLkDFMRARGYAHILALENLI 545

                         330       340       350
                  ....*....|....*....|....*....|
gi 578817221  796 KELEKNKSQMSGVEAAASDPSEKVKKIMNQ 825
Cdd:COG5185   546 PASELIQASNAKTDGQAANLRTAVIDELTQ 575

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

582-841

1.48e-10

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 65.86 E-value: 1.48e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   582 AQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEEL 661
Cdd:TIGR02169  674 AELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI 753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   662 TDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEqlslVQAELQtqwEAKC 741
Cdd:TIGR02169  754 ENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLRE----IEQKLN---RLTL 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   742 EHLLASAKDEHLQQYQEVC-AQRDAYQQKLVQLQEKCLALQAQItaltKQNEQHIKELEKNKSqmsgveaaasDPSEKVK 820
Cdd:TIGR02169  827 EKEYLEKEIQELQEQRIDLkEQIKSIEKEIENLNGKKEELEEEL----EELEAALRDLESRLG----------DLKKERD 892

                          250       260
                   ....*....|....*....|.
gi 578817221   821 KIMNQVFQSLRREFELEESYN 841
Cdd:TIGR02169  893 ELEAQLRELERKIEELEAQIE 913

SCP-1

pfam05483

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...

441-839

1.74e-10

Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 65.51 E-value: 1.74e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   441 MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMET--SMIMSNIQRIIQENERLK---QEILE 515
Cdd:pfam05483  309 MSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSleELLRTEQQRLEKNEDQLKiitMELQK 388

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   516 KSNRIEE----QNDKISELIERNQRYVEQSNLMMEKRNnsLQTATENTQARvlhaEQEkakVTEELAAATAQVSHLQLKM 591
Cdd:pfam05483  389 KSSELEEmtkfKNNKEVELEELKKILAEDEKLLDEKKQ--FEKIAEELKGK----EQE---LIFLLQAREKEIHDLEIQL 459

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   592 TA-------HQKKETELQMQL-TESLKETDLL---------RGQLTKVQAKLS-ELQETSEQAQSKFKSEKQNRKQLElk 653
Cdd:pfam05483  460 TAiktseehYLKEVEDLKTELeKEKLKNIELTahcdkllleNKELTQEASDMTlELKKHQEDIINCKKQEERMLKQIE-- 537

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   654 vtSLEEELTDLRVEKESLEKNLSERK-------KKSAQERSQAEEEI--------------DEIRKSYQEELDKLRQLLK 712
Cdd:pfam05483  538 --NLEEKEMNLRDELESVREEFIQKGdevkcklDKSEENARSIEYEVlkkekqmkilenkcNNLKKQIENKNKNIEELHQ 615

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   713 KTRVSTDQAAAEQLSLVQAELQTQweaKCEHLLASAK---DEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 789
Cdd:pfam05483  616 ENKALKKKGSAENKQLNAYEIKVN---KLELELASAKqkfEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQK 692

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578817221   790 QNE---QH-----IKELEKNKSQMSGVeAAASDPSEKVKKIMNQVFQSLRREFELEES 839
Cdd:pfam05483  693 EIDkrcQHkiaemVALMEKHKHQYDKI-IEERDSELGLYKNKEQEQSSAKAALEIELS 749

EnvC

COG4942

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

615-820

3.40e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 63.24 E-value: 3.40e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  615 LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLserkKKSAQERSQAEEEID 694
Cdd:COG4942    25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL----AELEKEIAELRAELE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  695 EIRKSYQEELDKL-----------------------RQLLKKTRVSTDQAAAEQLSLVQAELQTQweakcEHLLASAKDE 751
Cdd:COG4942   101 AQKEELAELLRALyrlgrqpplalllspedfldavrRLQYLKYLAPARREQAEELRADLAELAAL-----RAELEAERAE 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578817221  752 HLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVK 820
Cdd:COG4942   176 LEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244

EnvC

COG4942

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

593-793

4.02e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 63.24 E-value: 4.02e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  593 AHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLE 672
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  673 KNLSERKKKSAQ---------------------------ERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTdQAAAEQ 725
Cdd:COG4942    97 AELEAQKEELAEllralyrlgrqpplalllspedfldavRRLQYLKYLAPARREQAEELRADLAELAALRAEL-EAERAE 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578817221  726 LSLVQAELQTQWEAkcehlLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQ 793
Cdd:COG4942   176 LEALLAELEEERAA-----LEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

493-826

5.36e-10

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 63.89 E-value: 5.36e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   493 SMIMSNIQRIIQENER---LKQEI-------LEKSNRIEEQNDKISELIERNQRYVEQ--------SNL-----MMEKRN 549
Cdd:TIGR04523  328 NQISQNNKIISQLNEQisqLKKELtnsesenSEKQRELEEKQNEIEKLKKENQSYKQEiknlesqiNDLeskiqNQEKLN 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   550 NSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQmQLTESLKE-TDLLRGQLTKVQAKLSE 628
Cdd:TIGR04523  408 QQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLD-NTRESLETqLKVLSRSINKIKQNLEQ 486

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   629 LQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEkeslEKNLSERKKKSAQERSQAEEEIDEIrksyqeELDKLR 708
Cdd:TIGR04523  487 KQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEK----IEKLESEKKEKESKISDLEDELNKD------DFELKK 556

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   709 QLLKKTRVSTDQaAAEQLSLVQAEL---QTQweakcehllasaKDEHLQQyqevcaqrdaYQQKLVQLQEKCLALQAQIT 785
Cdd:TIGR04523  557 ENLEKEIDEKNK-EIEELKQTQKSLkkkQEE------------KQELIDQ----------KEKEKKDLIKEIEEKEKKIS 613

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 578817221   786 ALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQV 826
Cdd:TIGR04523  614 SLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETI 654

DUF5401

pfam17380

Family of unknown function (DUF5401); This is a family of unknown function found in ...

500-822

7.69e-10

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.

Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 63.22 E-value: 7.69e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   500 QRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEkRNNSLQTATENTQARvlhaEQEKAKvTEELAA 579
Cdd:pfam17380  299 ERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAME-RERELERIRQEERKR----ELERIR-QEEIAM 372

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   580 ATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQetseqaqsKFKSEKQNRKQLELKVTSLEE 659
Cdd:pfam17380  373 EISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEME--------QIRAEQEEARQREVRRLEEER 444

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   660 ELTDLRVEKESLEKNLS-ERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ---LSLVQAELQT 735
Cdd:pfam17380  445 AREMERVRLEEQERQQQvERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEerkRKLLEKEMEE 524

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   736 QWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKclalqAQITALTKQNE--QHIKELEKNKSqmsgvEAAAS 813
Cdd:pfam17380  525 RQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEER-----SRLEAMEREREmmRQIVESEKARA-----EYEAT 594


                   ....*....
gi 578817221   814 DPSEKVKKI 822
Cdd:pfam17380  595 TPITTIKPI 603

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

497-713

1.30e-09

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 62.35 E-value: 1.30e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   497 SNIQRIIQENERLKQEILEKSNRIEEQNDKISELIER------------NQRYVEQSNL-MMEKRNNSLQTATENTQARV 563
Cdd:TIGR04523  412 EQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQdsvkeliiknldNTRESLETQLkVLSRSINKIKQNLEQKQKEL 491

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   564 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTE------SLK------ETDLLRGQLTKV----QAKLS 627
Cdd:TIGR04523  492 KSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEkeskisDLEdelnkdDFELKKENLEKEidekNKEIE 571

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   628 ELQET---SEQAQSKFK-------SEKQN-RKQLELK---VTSLEEELTDLRVEKESLE---KNLSERKKKSAQERSQAE 690
Cdd:TIGR04523  572 ELKQTqksLKKKQEEKQelidqkeKEKKDlIKEIEEKekkISSLEKELEKAKKENEKLSsiiKNIKSKKNKLKQEVKQIK 651

                          250       260
                   ....*....|....*....|...
gi 578817221   691 EEIDEIRKSYQEELDKLRQLLKK 713
Cdd:TIGR04523  652 ETIKEIRNKWPEIIKKIKESKTK 674

PRK10902

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional

123-241

1.34e-09

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional

Pssm-ID: 236791 [Multi-domain] Cd Length: 269 Bit Score: 60.55 E-value: 1.34e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  123 GPAVEVGDSLEVAYTGWLfqnhVLGQVFDSTANKDKLLRLKLGSgkVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVI 202
Cdd:PRK10902  158 GEAPKDSDTVVVNYKGTL----IDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVP 231

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 578817221  203 GWtqATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAA 241
Cdd:PRK10902  232 GI--PANSTLVFDVELLDVKPAPKADAKPEADAKAADSA 268

PTZ00121

MAEBL; Provisional

507-797

1.73e-09

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 62.47 E-value: 1.73e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  507 ERLKQEILEKSNRIEEQNDKiseliernqRYVEQSNLMMEKRNNSLQTATENTQArvlhaeqEKAKVTEELaaataQVSH 586
Cdd:PTZ00121 1544 EKKKADELKKAEELKKAEEK---------KKAEEAKKAEEDKNMALRKAEEAKKA-------EEARIEEVM-----KLYE 1602

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  587 LQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQ------------AQSKFKSEKQNRKQLELKV 654
Cdd:PTZ00121 1603 EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElkkaeeenkikaAEEAKKAEEDKKKAEEAKK 1682

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  655 tslEEEltDLRVEKESLEKNlSERKKKSAQERSQAEEEI---DEIRKSYQEELDKLRQLLKKTRvsTDQAAAEQLSLVQA 731
Cdd:PTZ00121 1683 ---AEE--DEKKAAEALKKE-AEEAKKAEELKKKEAEEKkkaEELKKAEEENKIKAEEAKKEAE--EDKKKAEEAKKDEE 1754

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578817221  732 ElqtqwEAKCEHLlasaKDEHLQQYQEVCAQRDAY-QQKLVQLQEKCLALQAQITALTKQNEQHIKE 797
Cdd:PTZ00121 1755 E-----KKKIAHL----KKEEEKKAEEIRKEKEAViEEELDEEDEKRRMEVDKKIKDIFDNFANIIE 1812

CCDC22

pfam05667

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...

505-805

2.71e-09

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.

Pssm-ID: 461708 [Multi-domain] Cd Length: 600 Bit Score: 61.20 E-value: 2.71e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   505 ENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLmmekrnnslqtATENTQARVLHAEQEKAKVTEEL-AAATAQ 583
Cdd:pfam05667  223 EEEWNSQGLASRLTPEEYRKRKRTKLLKRIAEQLRSAAL-----------AGTEATSGASRSAQDLAELLSSFsGSSTTD 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   584 VSHLQLKMTAHQKKET---ELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEE 660
Cdd:pfam05667  292 TGLTKGSRFTHTEKLQftnEAPAATSSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEE 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   661 LTDLRVEKESLEKNLsERKKKSAQERSQAEEEIdeirksyqeelDKLRQLLkktrvstdQAAAEQLslvqAELQTQWEAK 740
Cdd:pfam05667  372 LEELKEQNEELEKQY-KVKKKTLDLLPDAEENI-----------AKLQALV--------DASAQRL----VELAGQWEKH 427

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578817221   741 CEHLLasakdEHLQQYQEVCA-QRDAYQQKLVQLQ---EKCLalqaQITALTKQNEQHIKELEKNKSQM 805
Cdd:pfam05667  428 RVPLI-----EEYRALKEAKSnKEDESQRKLEEIKelrEKIK----EVAEEAKQKEELYKQLVAEYERL 487

SCP-1

pfam05483

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...

450-840

3.83e-09

Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 60.89 E-value: 3.83e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   450 EIRMAVSKVADKMDHLMTKVEELQKHsAGNSMLipSMSVTMETSMimSNIQRIIQE-----NERLKQ------EILEKSN 518
Cdd:pfam05483  180 ETRQVYMDLNNNIEKMILAFEELRVQ-AENARL--EMHFKLKEDH--EKIQHLEEEykkeiNDKEKQvsllliQITEKEN 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   519 R-------IEEQNDKISELIERNQRYVEQSNLMMEKRNNsLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLqlkm 591
Cdd:pfam05483  255 KmkdltflLEESRDKANQLEEKTKLQDENLKELIEKKDH-LTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQL---- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   592 tahqKKETELQMQLTESLKETDLLrgQLTKVQAKLSELQETSEQAQSKFKSEKQNRK--QLELKVTSLE-EELTDLR--- 665
Cdd:pfam05483  330 ----TEEKEAQMEELNKAKAAHSF--VVTEFEATTCSLEELLRTEQQRLEKNEDQLKiiTMELQKKSSElEEMTKFKnnk 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   666 -VEKESLEKNLSERKK---------KSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVStDQAAAEQLSLVQAELQ- 734
Cdd:pfam05483  404 eVELEELKKILAEDEKlldekkqfeKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTS-EEHYLKEVEDLKTELEk 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   735 -----TQWEAKCEHLLASAKD---------EHLQQYQEVCAQRDAYQQKLVQ----LQEKCLALQAQITALTKQNEQHIK 796
Cdd:pfam05483  483 eklknIELTAHCDKLLLENKEltqeasdmtLELKKHQEDIINCKKQEERMLKqienLEEKEMNLRDELESVREEFIQKGD 562

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 578817221   797 E----LEKNKSQMSGVEAAASdPSEKVKKIMNQVFQSLRREFELEESY 840
Cdd:pfam05483  563 EvkckLDKSEENARSIEYEVL-KKEKQMKILENKCNNLKKQIENKNKN 609

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

449-673

4.48e-09

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 60.84 E-value: 4.48e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   449 TEIRMAVSKVADKMDHLMTKVEELQKhsagnsmlipsmsvtmETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKIS 528
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALAN----------------EISRLEQQKQILRERLANLERQLEELEAQLEELESKLD 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   529 ELIERNQRYVEQSNL--------------------MMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQ 588
Cdd:TIGR02168  334 ELAEELAELEEKLEElkeelesleaeleeleaeleELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLE 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   589 lkmtAHQKKETELQMQLTESLKETDL--LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRV 666
Cdd:TIGR02168  414 ----DRRERLQQEIEELLKKLEEAELkeLQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQA 489


                   ....*..
gi 578817221   667 EKESLEK 673
Cdd:TIGR02168  490 RLDSLER 496

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

499-841

4.52e-09

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 60.80 E-value: 4.52e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   499 IQRIIQENER---LKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNsLQTATENTQARVLHAEQEKAKVTE 575
Cdd:TIGR04523   67 EEKINNSNNKikiLEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNK-LEVELNKLEKQKKENKKNIDKFLT 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   576 ELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELqetsEQAQSKFKSEKQNRKQLELKVT 655
Cdd:TIGR04523  146 EIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKL----ELLLSNLKKKIQKNKSLESQIS 221

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   656 SLEEELTDLRVEKESLEKNLSERK---KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDqaaaeQLSLVQAE 732
Cdd:TIGR04523  222 ELKKQNNQLKDNIEKKQQEINEKTteiSNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEK-----QLNQLKSE 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   733 LQTQWEAKCEHLLASAKDEHLQ---QYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVE 809
Cdd:TIGR04523  297 ISDLNNQKEQDWNKELKSELKNqekKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLK 376

                          330       340       350
                   ....*....|....*....|....*....|..
gi 578817221   810 AAASDPSEKVKKIMNQVfQSLRREFELEESYN 841
Cdd:TIGR04523  377 KENQSYKQEIKNLESQI-NDLESKIQNQEKLN 407

YhaN

COG4717

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

596-813

4.61e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 60.55 E-value: 4.61e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  596 KKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQaqskfksekqnRKQLELKVTSLEEELTDLRVEKESLEKnl 675
Cdd:COG4717    64 RKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEE-----------LEELEAELEELREELEKLEKLLQLLPL-- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  676 serkkksAQERSQAEEEIDEirksYQEELDKLRQllKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE---H 752
Cdd:COG4717   131 -------YQELEALEAELAE----LPERLEELEE--RLEELRELEEELEELEAELAELQEELEELLEQLSLATEEElqdL 197

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817221  753 LQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALtkQNEQHIKELEKNKSQMSGVEAAAS 813
Cdd:COG4717   198 AEELEELQQRLAELEEELEEAQEELEELEEELEQL--ENELEAAALEERLKEARLLLLIAA 256

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

495-733

1.07e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 59.54 E-value: 1.07e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRIIQENERLK--QEILEKsnrIEEQNDKISELIERNQRYVEQSNLMMEKRnnslqtaTENTQARVLHAEQEKAK 572
Cdd:COG4913   223 TFEAADALVEHFDDLEraHEALED---AREQIELLEPIRELAERYAAARERLAELE-------YLRAALRLWFAQRRLEL 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  573 VTEELAAATAQVSHLQLKMTAHQKKETELQMQLTEslketdlLRGQLTKVQ-AKLSELQETSEQAQSKFKSEKQNRKQLE 651
Cdd:COG4913   293 LEAELEELRAELARLEAELERLEARLDALREELDE-------LEAQIRGNGgDRLEQLEREIERLERELEERERRRARLE 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  652 LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQL------LKKTRVSTDQ----- 720
Cdd:COG4913   366 ALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELeaeiasLERRKSNIPArllal 445

                         250
                  ....*....|....*
gi 578817221  721 --AAAEQLSLVQAEL 733
Cdd:COG4913   446 rdALAEALGLDEAEL 460

COG4372

Uncharacterized protein, contains DUF3084 domain [Function unknown];

507-734

1.22e-08

Uncharacterized protein, contains DUF3084 domain [Function unknown];

Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 58.38 E-value: 1.22e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  507 ERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTAT---ENTQARVLHAEQEKAKVTEELAAATAQ 583
Cdd:COG4372     2 DRLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLReelEQAREELEQLEEELEQARSELEQLEEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  584 VSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTD 663
Cdd:COG4372    82 LEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLES 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817221  664 LRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQ 734
Cdd:COG4372   162 LQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLG 232

sbcc

TIGR00618

exonuclease SbcC; All proteins in this family for which functions are known are part of an ...

505-834

1.47e-08

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]

Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 59.21 E-value: 1.47e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   505 ENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTatENTQARVLHAEQEKAKVTEELAAataQV 584
Cdd:TIGR00618  436 QQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQE--TRKKAVVLARLLELQEEPCPLCG---SC 510

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   585 SHLQLKMTAHQKKETeLQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDL 664
Cdd:TIGR00618  511 IHPNPARQDIDNPGP-LTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNL 589

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   665 RVEKESLEKnlsERKKKSAQERSQAEEEIDEIRKSyQEELDKLRQLLKKTRVSTDQAAAEqLSLVQAELQTQWEAKCEHL 744
Cdd:TIGR00618  590 QNITVRLQD---LTEKLSEAEDMLACEQHALLRKL-QPEQDLQDVRLHLQQCSQELALKL-TALHALQLTLTQERVREHA 664

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   745 LASAKDEhLQQYQEVCAQRDAYQQKLVQLQEKCLALqAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMN 824
Cdd:TIGR00618  665 LSIRVLP-KELLASRQLALQKMQSEKEQLTYWKEML-AQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALN 742

                          330
                   ....*....|
gi 578817221   825 QVFQSLRREF 834
Cdd:TIGR00618  743 QSLKELMHQA 752

EnvC

COG4942

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

495-737

1.49e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 58.24 E-value: 1.49e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLmMEKRNNSLQTATENTQARVlhaEQEKAKVT 574
Cdd:COG4942    32 LQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAA-LEAELAELEKEIAELRAEL---EAQKEELA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  575 EELAAA--TAQVSHLQLKMTAHQKKETELQMQLTESLKETDllRGQLTKVQAKLSELQetseqaqskfksekQNRKQLEL 652
Cdd:COG4942   108 ELLRALyrLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR--REQAEELRADLAELA--------------ALRAELEA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  653 KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEElDKLRQLLKKTRVSTDQAAAEQLSLVQAE 732
Cdd:COG4942   172 ERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEA-EELEALIARLEAEAAAAAERTPAAGFAA 250


                  ....*
gi 578817221  733 LQTQW 737
Cdd:COG4942   251 LKGKL 255

PRK03918

DNA double-strand break repair ATPase Rad50;

497-846

1.50e-08

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 58.92 E-value: 1.50e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  497 SNIQRIIQENErlkQEILEKSNRIEEQNDKISELIERnQRYVEQSNLMMEKRNNSLqtatENTQARVLHAEQEKAKVTEE 576
Cdd:PRK03918  189 ENIEELIKEKE---KELEEVLREINEISSELPELREE-LEKLEKEVKELEELKEEI----EELEKELESLEGSKRKLEEK 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  577 LAAATAQVSHLQLKMTAHQKKETELQmQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLElkvtS 656
Cdd:PRK03918  261 IRELEERIEELKKEIEELEEKVKELK-ELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE----E 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  657 LEEELTDLRVEKESLEKNLSE---------------------RKKKSAQERSQAEEEIDEIRKS---YQEELDKLRQLLK 712
Cdd:PRK03918  336 KEERLEELKKKLKELEKRLEEleerhelyeeakakkeelerlKKRLTGLTPEKLEKELEELEKAkeeIEEEISKITARIG 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  713 --KTRVSTDQAAAEQLS-------LVQAELQtqwEAKCEHLLASAKDEH---LQQYQEVCAQRDAYQQKLVQLqEKCLAL 780
Cdd:PRK03918  416 elKKEIKELKKAIEELKkakgkcpVCGRELT---EEHRKELLEEYTAELkriEKELKEIEEKERKLRKELREL-EKVLKK 491

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817221  781 QAQITALTKQNEQhIKELEK--NKSQMSGVEAAASDpSEKVKKIMNQV---FQSLRREFELEESYNGRTIL 846
Cdd:PRK03918  492 ESELIKLKELAEQ-LKELEEklKKYNLEELEKKAEE-YEKLKEKLIKLkgeIKSLKKELEKLEELKKKLAE 560

DR0291

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...

546-713

1.65e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];

Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 56.47 E-value: 1.65e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  546 EKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMtahQKKETELQMqlteslketdlLRGQLTKVQAK 625
Cdd:COG1579    16 DSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEI---KRLELEIEE-----------VEARIKKYEEQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  626 LSELQETSE-QA-QSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEE 703
Cdd:COG1579    82 LGNVRNNKEyEAlQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEEL 161

                         170
                  ....*....|
gi 578817221  704 LDKLRQLLKK 713
Cdd:COG1579   162 EAEREELAAK 171

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

442-707

1.73e-08

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 58.93 E-value: 1.73e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   442 TEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSmsvtmetsmIMSNIQRIIQENERLKQEILEKSNRIE 521
Cdd:TIGR02169  698 RRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEE---------LEEDLSSLEQEIENVKSELKELEARIE 768

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   522 EQNDKISEL------------------IERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQ 583
Cdd:TIGR02169  769 ELEEDLHKLeealndlearlshsripeIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQ 848

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   584 -------VSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTS 656
Cdd:TIGR02169  849 iksiekeIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEA 928

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   657 LEEELTDL----RVEKESLEKNLSERKKKSAQERSQAE---------------EEIDEIRKSYQEELDKL 707
Cdd:TIGR02169  929 LEEELSEIedpkGEDEEIPEEELSLEDVQAELQRVEEEiralepvnmlaiqeyEEVLKRLDELKEKRAKL 998

GAS

pfam13851

Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...

590-735

3.11e-08

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.

Pssm-ID: 464001 [Multi-domain] Cd Length: 200 Bit Score: 54.91 E-value: 3.11e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   590 KMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQaqskFKSEKQNRKQLELKVTSLEEELTDLRVEKE 669
Cdd:pfam13851   34 EIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLEN----YEKDKQSLKNLKARLKVLEKELKDLKWEHE 109

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221   670 SLEknlsERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKtRVstdQAAAEQLSLVQAELQT 735
Cdd:pfam13851  110 VLE----QRFEKVERERDELYDKFEAAIQDVQQKTGLKNLLLEK-KL---QALGETLEKKEAQLNE 167

Myosin_tail_1

pfam01576

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...

527-835

4.28e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.

Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 57.88 E-value: 4.28e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   527 ISELIERNQRYvEQSNLMMEK-------RNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKET 599
Cdd:pfam01576  189 ISDLEERLKKE-EKGRQELEKakrklegESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIR 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   600 ELQMQLTESLKETDLLRGQLTKV-----------QAKLSELQET--SEQAQSKFKSEKQN-----RKQLELKVTSLEEEL 661
Cdd:pfam01576  268 ELEAQISELQEDLESERAARNKAekqrrdlgeelEALKTELEDTldTTAAQQELRSKREQevtelKKALEEETRSHEAQL 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   662 TDLRVE------------------KESLEKNL----SERKKKSAQERS--QAEEEIDEIRKSYQEELDKLRQLLKKT-RV 716
Cdd:pfam01576  348 QEMRQKhtqaleelteqleqakrnKANLEKAKqaleSENAELQAELRTlqQAKQDSEHKRKKLEGQLQELQARLSESeRQ 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   717 STDqaAAEQLSLVQAELQT------QWEAKCEHLL--ASAKDEHLQQYQEVCA----QRDAYQQKLVQLQEKCLALQAQI 784
Cdd:pfam01576  428 RAE--LAEKLSKLQSELESvssllnEAEGKNIKLSkdVSSLESQLQDTQELLQeetrQKLNLSTRLRQLEDERNSLQEQL 505

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578817221   785 -------TALTKQNEQHIKELEKNKSQMSGvEAAASDPSEKVKKIMNQVFQSLRREFE 835
Cdd:pfam01576  506 eeeeeakRNVERQLSTLQAQLSDMKKKLEE-DAGTLEALEEGKKRLQRELEALTQQLE 562

PRK03918

DNA double-strand break repair ATPase Rad50;

514-802

4.45e-08

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 57.38 E-value: 4.45e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  514 LEKSNRIEEQNDKISELIER--------NQRYVEQ--------SNLMMEK------RNNSLQTATENTQaRVLHAEQEKA 571
Cdd:PRK03918  100 LDGSEVLEEGDSSVREWVERlipyhvflNAIYIRQgeidaileSDESREKvvrqilGLDDYENAYKNLG-EVIKEIKRRI 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  572 KVTEELAAATAQVshlqlkmtahQKKETELQMQLTESLKETDL-------LRGQLTKVQAKLSELQETSE---QAQSKFK 641
Cdd:PRK03918  179 ERLEKFIKRTENI----------EELIKEKEKELEEVLREINEisselpeLREELEKLEKEVKELEELKEeieELEKELE 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  642 SEKQNRKQLELKVTSLEEELTDLRVEKESLEKNlsERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRvstdqa 721
Cdd:PRK03918  249 SLEGSKRKLEEKIRELEERIEELKKEIEELEEK--VKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLE------ 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  722 aaEQLSLVQAELQtQWEAKCEHL--LASAKDEHLQQYQEVCAQRDAYQ---QKLVQLQEkclaLQAQITALTKQN-EQHI 795
Cdd:PRK03918  321 --EEINGIEERIK-ELEEKEERLeeLKKKLKELEKRLEELEERHELYEeakAKKEELER----LKKRLTGLTPEKlEKEL 393


                  ....*..
gi 578817221  796 KELEKNK 802
Cdd:PRK03918  394 EELEKAK 400

GumC

COG3206

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];

557-785

5.19e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 57.33 E-value: 5.19e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  557 ENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKE--TELQMQLTESLKETDLLRGQLTKVQAKLSELQETSE 634
Cdd:COG3206   164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNglVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLA 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  635 QAQSKFKSEKQNRKQL--ELKVTSLEEELTDLRVEKESLEKNLSERkkksAQERSQAEEEIDEIRKSYQEELDKLRQLLk 712
Cdd:COG3206   244 ALRAQLGSGPDALPELlqSPVIQQLRAQLAELEAELAELSARYTPN----HPDVIALRAQIAALRAQLQQEAQRILASL- 318

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817221  713 KTRVSTDQAAAEQLSLVQAELQTQWEAkcehlLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEkcLALQAQIT 785
Cdd:COG3206   319 EAELEALQAREASLQAQLAQLEARLAE-----LPELEAELRRLEREVEVARELYESLLQRLEE--ARLAEALT 384

PTZ00121

MAEBL; Provisional

505-845

5.24e-08

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 57.46 E-value: 5.24e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  505 ENERLKQEILEKSN--RIEEQNDKISELIERNQRYVEQSNLMMEKRN-NSLQTATENTQARVLHAEQEKAKVTE--ELAA 579
Cdd:PTZ00121 1233 EEAKKDAEEAKKAEeeRNNEEIRKFEEARMAHFARRQAAIKAEEARKaDELKKAEEKKKADEAKKAEEKKKADEakKKAE 1312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  580 ATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQN-----------RK 648
Cdd:PTZ00121 1313 EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKadaakkkaeekKK 1392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  649 QLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE---------EIDEIRKSyQEELDKLRQLLKKtrvSTD 719
Cdd:PTZ00121 1393 ADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEakkkaeeakKADEAKKK-AEEAKKAEEAKKK---AEE 1468

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  720 QAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEvcAQRDAyqQKLVQLQEKCLALQAQITALTKQNEQHIKELE 799
Cdd:PTZ00121 1469 AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAE--AKKKA--DEAKKAEEAKKADEAKKAEEAKKADEAKKAEE 1544

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 578817221  800 KNKSQMSGvEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTI 845
Cdd:PTZ00121 1545 KKKADELK-KAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKA 1589

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

577-803

5.46e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 57.23 E-value: 5.46e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  577 LAAATAQVSHLQLKMTAHQKKETELQmQLtESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKsekqnrkqlELKVTS 656
Cdd:COG4913   224 FEAADALVEHFDDLERAHEALEDARE-QI-ELLEPIRELAERYAAARERLAELEYLRAALRLWFA---------QRRLEL 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  657 LEEELTDLRVEKESLEknlsERKKKSAQERSQAEEEIDEIRKSYQE----ELDKLRQLLKktrvstdqAAAEQLSLVQAE 732
Cdd:COG4913   293 LEAELEELRAELARLE----AELERLEARLDALREELDELEAQIRGnggdRLEQLEREIE--------RLERELEERERR 360

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578817221  733 LQtQWEAKCEHL---LASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQH---IKELEKNKS 803
Cdd:COG4913   361 RA-RLEALLAALglpLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELeaeIASLERRKS 436

CCDC158

pfam15921

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...

510-802

5.53e-08

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.

Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 57.44 E-value: 5.53e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   510 KQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTE---ELAAATAQVSH 586
Cdd:pfam15921  456 KNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKlrsRVDLKLQELQH 535

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   587 LQLKMTAHQKKETE---LQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQ-SKFKSEKQ-NRKQLEL--------- 652
Cdd:pfam15921  536 LKNEGDHLRNVQTEceaLKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQvEKAQLEKEiNDRRLELqefkilkdk 615

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   653 ---KVTSLEEELTDLRVEKESLEKNLSER---KKKSAQERSQAEEEIDEIR---KSYQEELDKLRQLLK---KTRVSTDQ 720
Cdd:pfam15921  616 kdaKIRELEARVSDLELEKVKLVNAGSERlraVKDIKQERDQLLNEVKTSRnelNSLSEDYEVLKRNFRnksEEMETTTN 695

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   721 AAAEQLSLVQAEL-QTQWEAKC-EHLLASAKDEHLQQYQEVCAQR---DAYQQKLVQLQEkclalqaqitALTKQN-EQH 794
Cdd:pfam15921  696 KLKMQLKSAQSELeQTRNTLKSmEGSDGHAMKVAMGMQKQITAKRgqiDALQSKIQFLEE----------AMTNANkEKH 765


                   ....*...
gi 578817221   795 IKELEKNK 802
Cdd:pfam15921  766 FLKEEKNK 773

YhaN

COG4717

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

568-739

5.55e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 57.08 E-value: 5.55e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  568 QEKAKVTEELAAATAQVSHL--QLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQ 645
Cdd:COG4717    81 KEAEEKEEEYAELQEELEELeeELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  646 NRKQLElkvtSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 725
Cdd:COG4717   161 LEEELE----ELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENEL 236

                         170
                  ....*....|....
gi 578817221  726 LSLVQAELQTQWEA 739
Cdd:COG4717   237 EAAALEERLKEARL 250

COG1340

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

573-825

6.71e-08

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 55.69 E-value: 6.71e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  573 VTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL 652
Cdd:COG1340     6 LSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  653 KVTSLEEELTDLRVEKESLEKNLSERKKKSAQ----ERSQ------AEEE---IDEIRKsYQEELDKLRQLLKKTR-VST 718
Cdd:COG1340    86 KLNELREELDELRKELAELNKAGGSIDKLRKEierlEWRQqtevlsPEEEkelVEKIKE-LEKELEKAKKALEKNEkLKE 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  719 DQAAAEQLSLVQAELQTQWEAKCEhLLASAKDEHLQQYQ---EVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHI 795
Cdd:COG1340   165 LRAELKELRKEAEEIHKKIKELAE-EAQELHEEMIELYKeadELRKEADELHKEIVEAQEKADELHEEIIELQKELRELR 243

                         250       260       270
                  ....*....|....*....|....*....|..
gi 578817221  796 KELE--KNKSQMSGVEAAASDPSEKVKKIMNQ 825
Cdd:COG1340   244 KELKklRKKQRALKREKEKEELEEKAEEIFEK 275

SMC_N

pfam02463

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

461-846

7.64e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 56.90 E-value: 7.64e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   461 KMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERL--KQEILEKSNRIEEQNDKISELIERNQRYV 538
Cdd:pfam02463  633 ELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELqeKAESELAKEEILRRQLEIKKKEQREKEEL 712

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   539 EQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQvshlqlkmtahqKKETELQMQLTESLKETDLlrgq 618
Cdd:pfam02463  713 KKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRL------------KKEEKEEEKSELSLKEKEL---- 776

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   619 ltkvqaklsELQETSEQAQSkfksekqNRKQLELKVTSLEEELTdlrvEKESLEKNLSERKKKSAQERSQAEEEIDEIRK 698
Cdd:pfam02463  777 ---------AEEREKTEKLK-------VEEEKEEKLKAQEEELR----ALEEELKEEAELLEEEQLLIEQEEKIKEEELE 836

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   699 SYQEEL--DKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEvcaqrdayQQKLVQLQEK 776
Cdd:pfam02463  837 ELALELkeEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEE--------KKELEEESQK 908

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817221   777 CLALQAQITALTKQNEQHIKELEKNKSQ---MSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTIL 846
Cdd:pfam02463  909 LNLLEEKENEIEERIKEEAEILLKYEEEpeeLLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIE 981

PRK11281

mechanosensitive channel MscK;

588-799

8.69e-08

mechanosensitive channel MscK;

Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 56.84 E-value: 8.69e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  588 QLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFkseKQNRKQLE---------------- 651
Cdd:PRK11281   44 QLDALNKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQQLAQAPAKL---RQAQAELEalkddndeetretlst 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  652 LKVTSLEEELTDLRVEKESLEKNLSERKK-----KSAQERSQAeeEIDEirksYQEELDKLRQLLKKTRVSTDQAAAEQL 726
Cdd:PRK11281  121 LSLRQLESRLAQTLDQLQNAQNDLAEYNSqlvslQTQPERAQA--ALYA----NSQRLQQIRNLLKGGKVGGKALRPSQR 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  727 SLVQAELQtqweakcehlLASAKDEHLQQ-----------YQevcAQRDAYQQKLVQLQEKCLALQAQITA-LTKQNEQH 794
Cdd:PRK11281  195 VLLQAEQA----------LLNAQNDLQRKslegntqlqdlLQ---KQRDYLTARIQRLEHQLQLLQEAINSkRLTLSEKT 261


                  ....*
gi 578817221  795 IKELE 799
Cdd:PRK11281  262 VQEAQ 266

PRK02224

DNA double-strand break repair Rad50 ATPase;

507-819

1.01e-07

DNA double-strand break repair Rad50 ATPase;

Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 56.59 E-value: 1.01e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  507 ERLKQEILEKSN-----RIEEQNDKISELIERNQRYVEQSNLMMEKRNN--SLQTATENTQARVLHAEQEKAKVTEELAA 579
Cdd:PRK02224  190 DQLKAQIEEKEEkdlheRLNGLESELAELDEEIERYEEQREQARETRDEadEVLEEHEERREELETLEAEIEDLRETIAE 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  580 ATAQVSHLQLKMTAHQKKETELQMQLTESLKETDL-------LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL 652
Cdd:PRK02224  270 TEREREELAEEVRDLRERLEELEEERDDLLAEAGLddadaeaVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLRE 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  653 KVTSLEEELTDLRVEKESLEKNLSERK---KKSAQERSQAEEEIDEIRKSYQ------EELDKLRQLLKKTRvstdQAAA 723
Cdd:PRK02224  350 DADDLEERAEELREEAAELESELEEAReavEDRREEIEELEEEIEELRERFGdapvdlGNAEDFLEELREER----DELR 425

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  724 EQLSLVQAELQTQWE--AKCEHLLASAKDEHLQQYQE----VCAQRDaYQQKLVQLQEKCLALQAQITALTKQNEQhIKE 797
Cdd:PRK02224  426 EREAELEATLRTARErvEEAEALLEAGKCPECGQPVEgsphVETIEE-DRERVEELEAELEDLEEEVEEVEERLER-AED 503

                         330       340
                  ....*....|....*....|..
gi 578817221  798 LEKNKSQMSGVEAAASDPSEKV 819
Cdd:PRK02224  504 LVEAEDRIERLEERREDLEELI 525

COG1340

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

487-725

1.17e-07

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 54.92 E-value: 1.17e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  487 SVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHA 566
Cdd:COG1340     5 ELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  567 EQEKaKVTEELAAATAQVSHLQLKMTAHQKKETELQ----MQLTESL---KETDL------LRGQLTKVQAKL---SELQ 630
Cdd:COG1340    85 EKLN-ELREELDELRKELAELNKAGGSIDKLRKEIErlewRQQTEVLspeEEKELvekikeLEKELEKAKKALeknEKLK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  631 ETSEQAQSKFKSEKQNRKQLE----------LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKsY 700
Cdd:COG1340   164 ELRAELKELRKEAEEIHKKIKelaeeaqelhEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEIIELQKELRE-L 242

                         250       260
                  ....*....|....*....|....*
gi 578817221  701 QEELDKLRQLLKKTRVSTDQAAAEQ 725
Cdd:COG1340   243 RKELKKLRKKQRALKREKEKEELEE 267

DR0291

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...

566-764

1.31e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];

Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 53.78 E-value: 1.31e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  566 AEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKfksEKQ 645
Cdd:COG1579     1 AMPEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEAR---IKK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  646 NRKQLElKVTSlEEELTDLRVEKESLEKNLSERKKksaqERSQAEEEIDEIRKSY---QEELDKLRQLLKKTRVSTDQAA 722
Cdd:COG1579    78 YEEQLG-NVRN-NKEYEALQKEIESLKRRISDLED----EILELMERIEELEEELaelEAELAELEAELEEKKAELDEEL 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 578817221  723 AEqlslVQAELQTQwEAKCEHLLASAKDEHLQQYQEVCAQRD 764
Cdd:COG1579   152 AE----LEAELEEL-EAEREELAAKIPPELLALYERIRKRKN 188

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

595-838

1.49e-07

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 55.83 E-value: 1.49e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   595 QKKETELQMQLTEslkeTDLLRGQ--LTKVQAKLSELQETSEQAQsKFKSEKQNRKQLELKVTsleeeLTDLRVEKESLE 672
Cdd:TIGR02168  173 RRKETERKLERTR----ENLDRLEdiLNELERQLKSLERQAEKAE-RYKELKAELRELELALL-----VLRLEELREELE 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   673 KNLSErKKKSAQERSQAEEEIDEirksYQEELDKLRqlLKKTRVSTDQAAAeqlslvQAELQTQWEAKcehllaSAKDEH 752
Cdd:TIGR02168  243 ELQEE-LKEAEEELEELTAELQE----LEEKLEELR--LEVSELEEEIEEL------QKELYALANEI------SRLEQQ 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   753 LQQYQEvcaqrdayqqKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR 832
Cdd:TIGR02168  304 KQILRE----------RLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESR 373


                   ....*.
gi 578817221   833 EFELEE 838
Cdd:TIGR02168  374 LEELEE 379

Filament

pfam00038

Intermediate filament protein;

587-811

1.96e-07

Intermediate filament protein;

Pssm-ID: 459643 [Multi-domain] Cd Length: 313 Bit Score: 54.16 E-value: 1.96e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   587 LQLKMTAHQKKETELQMQLtESLKETDL--LRGQL-------TKVQAKLSELQETSEQAQSKFKSEKQNRkqlelkvTSL 657
Cdd:pfam00038   30 LETKISELRQKKGAEPSRL-YSLYEKEIedLRRQLdtltverARLQLELDNLRLAAEDFRQKYEDELNLR-------TSA 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   658 EEELTDLR--VEKESLEKNLSERKKKSAQErsqaeeEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQA--EL 733
Cdd:pfam00038  102 ENDLVGLRkdLDEATLARVDLEAKIESLKE------ELAFLKKNHEEEVRELQAQVSDTQVNVEMDAARKLDLTSAlaEI 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   734 QTQWEAKCEHLLASAKDEHLQQYQEVCAQRD-------AYQQKLVQLQEKCLALQAQITALTKQN-----------EQHI 795
Cdd:pfam00038  176 RAQYEEIAAKNREEAEEWYQSKLEELQQAAArngdalrSAKEEITELRRTIQSLEIELQSLKKQKaslerqlaeteERYE 255

                          250
                   ....*....|....*.
gi 578817221   796 KELEKNKSQMSGVEAA 811
Cdd:pfam00038  256 LQLADYQELISELEAE 271

PRK03918

DNA double-strand break repair ATPase Rad50;

498-837

1.97e-07

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 55.46 E-value: 1.97e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  498 NIQRIIQE----NERLKQEILEKSN---RIEEQNDKISELIErnqryvEQSNLMMEKRnnSLQTATENTQARVLHAEQEK 570
Cdd:PRK03918  166 NLGEVIKEikrrIERLEKFIKRTENieeLIKEKEKELEEVLR------EINEISSELP--ELREELEKLEKEVKELEELK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  571 akvtEELAAATAQVshlqLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQ--AQSKFKSEKQNRK 648
Cdd:PRK03918  238 ----EEIEELEKEL----ESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEyiKLSEFYEEYLDEL 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  649 QlelkvtSLEEELTDLRVEKESLEKNLSERKKKSAqERSQAEEEIDEIRKSYQE------ELDKLRQLLKKTRVSTDQAA 722
Cdd:PRK03918  310 R------EIEKRLSRLEEEINGIEERIKELEEKEE-RLEELKKKLKELEKRLEEleerheLYEEAKAKKEELERLKKRLT 382

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  723 AEQLSLVQAELQTQWEAKCEHLLASAK-DEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITaltkqnEQHIKELekn 801
Cdd:PRK03918  383 GLTPEKLEKELEELEKAKEEIEEEISKiTARIGELKKEIKELKKAIEELKKAKGKCPVCGRELT------EEHRKEL--- 453

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 578817221  802 ksqMSGVEAAASDPSEKVKKIMNQVFQSLRREFELE 837
Cdd:PRK03918  454 ---LEEYTAELKRIEKELKEIEEKERKLRKELRELE 486

DR0291

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...

511-709

2.23e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];

Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 53.00 E-value: 2.23e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  511 QEILEKSNRIEEQNDKISELIERnqryveqsnlmMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLK 590
Cdd:COG1579    13 QELDSELDRLEHRLKELPAELAE-----------LEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  591 MTAHqKKETELQmQLTeslKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLElkvTSLEEELTDLRVEKES 670
Cdd:COG1579    82 LGNV-RNNKEYE-ALQ---KEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELE---AELEEKKAELDEELAE 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 578817221  671 LEKNLSERKKksaqERSQAEEEIDE-IRKSYqeelDKLRQ 709
Cdd:COG1579   154 LEAELEELEA----EREELAAKIPPeLLALY----ERIRK 185

CwlO1

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...

566-817

3.24e-07

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];

Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 54.07 E-value: 3.24e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  566 AEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQET-SEQAQSKFKSEK 644
Cdd:COG3883    21 KQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREElGERARALYRSGG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  645 QNrKQLELKVTSleEELTDLrVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKtrVSTDQAAAE 724
Cdd:COG3883   101 SV-SYLDVLLGS--ESFSDF-LDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAE--LEAAKAELE 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  725 QLSLVQAELQTQweakcehlLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQ 804
Cdd:COG3883   175 AQQAEQEALLAQ--------LSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASA 246

                         250
                  ....*....|...
gi 578817221  805 MSGVEAAASDPSE 817
Cdd:COG3883   247 AGAGAAGAAGAAA 259

CwlO1

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...

604-818

3.39e-07

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];

Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 54.07 E-value: 3.39e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  604 QLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERkKKSA 683
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGER-ARAL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  684 QERSQAEEEIDEI--RKSYQEELDKLRQLlkKTRVSTDQAAAEQLSLVQAELQTQweakcEHLLASAKDEHLQQYQEVCA 761
Cdd:COG3883    96 YRSGGSVSYLDVLlgSESFSDFLDRLSAL--SKIADADADLLEELKADKAELEAK-----KAELEAKLAELEALKAELEA 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 578817221  762 QRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEK 818
Cdd:COG3883   169 AKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAA 225

PTZ00121

MAEBL; Provisional

504-820

5.25e-07

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 54.38 E-value: 5.25e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  504 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRN--NSLQTATENTQARVLHAEQEKAKVTEELA--A 579
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKaeEAKKKAEEAKKADEAKKKAEEAKKADEAKkkA 1492

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  580 ATAQVSHLQLKMTAHQKKETElQMQLTESLKETDLLRGQLTKVQA----------KLSELQETSE--QAQSKFKSEkQNR 647
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKAD-EAKKAEEAKKADEAKKAEEAKKAdeakkaeekkKADELKKAEElkKAEEKKKAE-EAK 1570

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  648 KQLELKVTSLEEELTDLRVEKESLE---KNLSERKKKSAQERSQAEEE---IDEIRKSyQEELDKLRQLLKKTRVSTDQA 721
Cdd:PTZ00121 1571 KAEEDKNMALRKAEEAKKAEEARIEevmKLYEEEKKMKAEEAKKAEEAkikAEELKKA-EEEKKKVEQLKKKEAEEKKKA 1649

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  722 -----AAEQLSLVQAELQTQWEA---KCEHLLASAKDEhlQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNE- 792
Cdd:PTZ00121 1650 eelkkAEEENKIKAAEEAKKAEEdkkKAEEAKKAEEDE--KKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEe 1727

                         330       340       350
                  ....*....|....*....|....*....|....
gi 578817221  793 ------QHIKELEKNKSQmsgVEAAASDPSEKVK 820
Cdd:PTZ00121 1728 nkikaeEAKKEAEEDKKK---AEEAKKDEEEKKK 1758

SMC_N

pfam02463

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

499-715

6.24e-07

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 53.82 E-value: 6.24e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   499 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQaRVLHAEQEKAKVTEELA 578
Cdd:pfam02463  814 AELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLK-EEELEEQKLKDELESKE 892

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   579 AATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQ-SKFKSEKQNRKQLELKVTSL 657
Cdd:pfam02463  893 EKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEeNNKEEEEERNKRLLLAKEEL 972

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578817221   658 EEEltDLRVEKESLEKNLSERKKKSAQERsqAEEEIDEIRksyQEELDKLRQLLKKTR 715
Cdd:pfam02463  973 GKV--NLMAIEEFEEKEERYNKDELEKER--LEEEKKKLI---RAIIEETCQRLKEFL 1023

CCCAP

pfam15964

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...

504-838

6.84e-07

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.

Pssm-ID: 435040 [Multi-domain] Cd Length: 703 Bit Score: 53.76 E-value: 6.84e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   504 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQ 583
Cdd:pfam15964  367 RQKERLEKELASQQEKRAQEKEALRKEMKKEREELGATMLALSQNVAQLEAQVEKVTREKNSLVSQLEEAQKQLASQEMD 446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   584 VSHL------QLKMTAHQKKETELQMQ--LTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVT 655
Cdd:pfam15964  447 VTKVcgemryQLNQTKMKKDEAEKEHReyRTKTGRQLEIKDQEIEKLGLELSESKQRLEQAQQDAARAREECLKLTELLG 526

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   656 SLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEideirksyqeeldkLRQLLKKTRVSTDQAAAEQLSLV--QAEL 733
Cdd:pfam15964  527 ESEHQLHLTRLEKESIQQSFSNEAKAQALQAQQREQE--------------LTQKMQQMEAQHDKTVNEQYSLLtsQNTF 592

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   734 QTQWEAKCeHLLASAKDEHLQQYQEVCAQrdaYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAAS 813
Cdd:pfam15964  593 IAKLKEEC-CTLAKKLEEITQKSRSEVEQ---LSQEKEYLQDRLEKLQKRNEELEEQCVQHGRMHERMKQRLRQLDKHCQ 668

                          330       340
                   ....*....|....*....|....*
gi 578817221   814 DPSEKVKKIMNQVFQSLRREFELEE 838
Cdd:pfam15964  669 ATAQQLVQLLSKQNQLFKERQNLTE 693

MukB

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...

510-800

7.07e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 53.80 E-value: 7.07e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  510 KQEILEKSNRIEEQNDKISELIERnQRYVEQSNLMMEKRNNSLQTATENtQARVLHAEQEKAKVTEELAAATAQVSHLQL 589
Cdd:COG3096   298 RRQLAEEQYRLVEMARELEELSAR-ESDLEQDYQAASDHLNLVQTALRQ-QEKIERYQEDLEELTERLEEQEEVVEEAAE 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  590 kmtahQKKETELQMQLTEslKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQL---ELKVTSLEEELTDLRV 666
Cdd:COG3096   376 -----QLAEAEARLEAAE--EEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALEKARALCglpDLTPENAEDYLAAFRA 448

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  667 EKESLEKNLSERKkksaQERSQAEEEIDEIRKSYQ------------EELDKLRQLLKKTRVSTDQAA-----------A 723
Cdd:COG3096   449 KEQQATEEVLELE----QKLSVADAARRQFEKAYElvckiageversQAWQTARELLRRYRSQQALAQrlqqlraqlaeL 524

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  724 EQLSLVQAELQTQWEAKCEHL---LASAKD-EHLQQYQEvcAQRDAYQQKLVQLQEKCLALQAQitalTKQNEQHIKELE 799
Cdd:COG3096   525 EQRLRQQQNAERLLEEFCQRIgqqLDAAEElEELLAELE--AQLEELEEQAAEAVEQRSELRQQ----LEQLRARIKELA 598


                  .
gi 578817221  800 K 800
Cdd:COG3096   599 A 599

Myosin_tail_1

pfam01576

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...

557-843

7.64e-07

Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 53.64 E-value: 7.64e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   557 ENTQARvlhaEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQL---TESLKETDLLRGQL-----------TKV 622
Cdd:pfam01576    5 EEMQAK----EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLqaeTELCAEAEEMRARLaarkqeleeilHEL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   623 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN----------LSERKKKSAQERSQAEEE 692
Cdd:pfam01576   81 ESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKikkleedillLEDQNSKLSKERKLLEER 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   693 IDEIRKSYQEELDKLRQLLKktrvstdqaaaeqlslvqaeLQTQWEAKCEHLLASAKDEHlQQYQEVCAQRDAYQQKLVQ 772
Cdd:pfam01576  161 ISEFTSNLAEEEEKAKSLSK--------------------LKNKHEAMISDLEERLKKEE-KGRQELEKAKRKLEGESTD 219

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817221   773 LQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQsLRREFELEESYNGR 843
Cdd:pfam01576  220 LQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISE-LQEDLESERAARNK 289

SMC_N

pfam02463

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...

499-838

1.04e-06

Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 53.05 E-value: 1.04e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   499 IQRIIQENERLKQEILE-----KSNRIEEQNDKisELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKV 573
Cdd:pfam02463  144 IEIIAMMKPERRLEIEEeaagsRLKRKKKEALK--KLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLEL 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   574 TEELAAATAQVSHLQlkmtahqkketelqmqlteslKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKqLELK 653
Cdd:pfam02463  222 EEEYLLYLDYLKLNE---------------------ERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENK-EEEK 279

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   654 VTSLEEEL-----TDLRVEKESLEK-----NLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAA 723
Cdd:pfam02463  280 EKKLQEEElkllaKEEEELKSELLKlerrkVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEE 359

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   724 EQLSLVQAELQTQWEAKCEHLLASA-------KDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIK 796
Cdd:pfam02463  360 ELEKLQEKLEQLEEELLAKKKLESErlssaakLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESI 439

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 578817221   797 ELEKNKSQMSGVEAaasDPSEKVKKIMNQVFQSLRREFELEE 838
Cdd:pfam02463  440 ELKQGKLTEEKEEL---EKQELKLLKDELELKKSEDLLKETQ 478

TPH

pfam13868

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...

503-838

1.40e-06

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.

Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 51.84 E-value: 1.40e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   503 IQENERLKQEILEKSNRIEEqndkiseliernqryveqsnlMMEKRNnslqtatENTQARVLHAEQEKAKVTEELAAAta 582
Cdd:pfam13868   28 IAEKKRIKAEEKEEERRLDE---------------------MMEEER-------ERALEEEEEKEEERKEERKRYRQE-- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   583 qvshLQLKMTAHQKKEtelQMQLTESLKETDLLRGQLTKVQAKlselqetsEQAQSKFKSEKQNRKQLELKVTSleeELT 662
Cdd:pfam13868   78 ----LEEQIEEREQKR---QEEYEEKLQEREQMDEIVERIQEE--------DQAEAEEKLEKQRQLREEIDEFN---EEQ 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   663 DLRVEKESLEKNLSERK-----KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVstDQAAAEQL--SLVQAELQT 735
Cdd:pfam13868  140 AEWKELEKEEEREEDERileylKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQD--EKAERDELraKLYQEEQER 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   736 QW-------EAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQhiKELEKNKSQMSGV 808
Cdd:pfam13868  218 KErqkereeAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAE--KRRMKRLEHRREL 295

                          330       340       350
                   ....*....|....*....|....*....|
gi 578817221   809 EAAASDPSEKVKKIMNQVFQSLRREFELEE 838
Cdd:pfam13868  296 EKQIEEREEQRAAEREEELEEGERLREEEA 325

DUF3584

pfam12128

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...

540-826

1.72e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.

Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 52.53 E-value: 1.72e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   540 QSNLMMEKRNNSLQTATENTQARvlHAEQEkakvtEELAAATAQVSHLQLKMT----AHQKKETELQMQLTESLKEtdll 615
Cdd:pfam12128  597 ASEEELRERLDKAEEALQSAREK--QAAAE-----EQLVQANGELEKASREETfartALKNARLDLRRLFDEKQSE---- 665

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   616 rgQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNL-SERKKKSAQ-------ERS 687
Cdd:pfam12128  666 --KDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVeGALDAQLALlkaaiaaRRS 743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   688 QAEEEIDEIRKSYQEELDKLrqllkktrvSTDQAAAEQLSLVQAELQTQWE--AKCEHLLASAKDEHLQQYQEvcaQRDA 765
Cdd:pfam12128  744 GAKAELKALETWYKRDLASL---------GVDPDVIAKLKREIRTLERKIEriAVRRQEVLRYFDWYQETWLQ---RRPR 811

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817221   766 YQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQV 826
Cdd:pfam12128  812 LATQLSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKL 872

DR0291

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...

507-678

1.93e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];

Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 50.31 E-value: 1.93e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  507 ERLKQEILEKSNRIEEQNDKISEL---IERNQRYVEQSNLMMEKRNNSLQTATENtqarvlhaeqekakvtEELAAATAQ 583
Cdd:COG1579    34 AELEDELAALEARLEAAKTELEDLekeIKRLELEIEEVEARIKKYEEQLGNVRNN----------------KEYEALQKE 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  584 VSHLQLKMTAHQKKETELQMQLTEslketdlLRGQLTKVQAKLSELQETSEQAQskfksekqnrKQLELKVTSLEEELTD 663
Cdd:COG1579    98 IESLKRRISDLEDEILELMERIEE-------LEEELAELEAELAELEAELEEKK----------AELDEELAELEAELEE 160

                         170
                  ....*....|....*
gi 578817221  664 LRVEKESLEKNLSER 678
Cdd:COG1579   161 LEAEREELAAKIPPE 175

PLN02939

transferase, transferring glycosyl groups

447-725

2.04e-06

transferase, transferring glycosyl groups

Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 52.21 E-value: 2.04e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  447 HNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSN---------IQRIIQENERLKQEILEKS 517
Cdd:PLN02939   97 HNRASMQRDEAIAAIDNEQQTNSKDGEQLSDFQLEDLVGMIQNAEKNILLLNqarlqaledLEKILTEKEALQGKINILE 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  518 NRIEEQNDKIsELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTahQKK 597
Cdd:PLN02939  177 MRLSETDARI-KLAAQEKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELI--EVA 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  598 ETELQMQLTEslKETDLLRGQLTKVQAKLSELQE--------------------------TSEQAQSKFKSEKQNRkQLE 651
Cdd:PLN02939  254 ETEERVFKLE--KERSLLDASLRELESKFIVAQEdvsklsplqydcwwekvenlqdlldrATNQVEKAALVLDQNQ-DLR 330

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221  652 LKVTSLEEELTDLRVEKESLEK-NLSERKKKSAQERSQA-EEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 725
Cdd:PLN02939  331 DKVDKLEASLKEANVSKFSSYKvELLQQKLKLLEERLQAsDHEIHSYIQLYQESIKEFQDTLSKLKEESKKRSLEH 406

PLN02939

transferase, transferring glycosyl groups

517-817

2.38e-06

transferase, transferring glycosyl groups

Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 51.83 E-value: 2.38e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  517 SNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENT----QARvLHAEQEKAKVTEELAAATAQVSHLQLKMT 592
Cdd:PLN02939  102 MQRDEAIAAIDNEQQTNSKDGEQLSDFQLEDLVGMIQNAEKNIlllnQAR-LQALEDLEKILTEKEALQGKINILEMRLS 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  593 ahqkkETELQMQLTESLK-ETDLLRGQLTKVQAKLSELQETSEQAqskfksekqnrkqlelkVTSLEEELTDLRVEKESL 671
Cdd:PLN02939  181 -----ETDARIKLAAQEKiHVEILEEQLEKLRNELLIRGATEGLC-----------------VHSLSKELDVLKEENMLL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  672 EKNLSERKkksaqersqaeEEIDEIRKSYQE--ELDKLRQLLKKT------RVSTDQAAAEQLSLVQAELqtqWEAKCE- 742
Cdd:PLN02939  239 KDDIQFLK-----------AELIEVAETEERvfKLEKERSLLDASlrelesKFIVAQEDVSKLSPLQYDC---WWEKVEn 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  743 --HLLASAKD--EH----LQQYQEV--------------------CAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQH 794
Cdd:PLN02939  305 lqDLLDRATNqvEKaalvLDQNQDLrdkvdkleaslkeanvskfsSYKVELLQQKLKLLEERLQASDHEIHSYIQLYQES 384

                         330       340       350
                  ....*....|....*....|....*....|
gi 578817221  795 IKELE------KNKSQMSGVEAAASD-PSE 817
Cdd:PLN02939  385 IKEFQdtlsklKEESKKRSLEHPADDmPSE 414

PRK02224

DNA double-strand break repair Rad50 ATPase;

500-814

2.39e-06

DNA double-strand break repair Rad50 ATPase;

Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 51.96 E-value: 2.39e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  500 QRIIQENERLKQEILEKSNRIEEQNDKISE---------------------LIERN------------------------ 534
Cdd:PRK02224  240 DEVLEEHEERREELETLEAEIEDLRETIAEterereelaeevrdlrerleeLEEERddllaeaglddadaeavearreel 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  535 -------QRYVEQSNLMMEKRNNSLQTATEN------------TQARVLHAEQEKAKvtEELAAATAQVSHLQLKMTAHQ 595
Cdd:PRK02224  320 edrdeelRDRLEECRVAAQAHNEEAESLREDaddleeraeelrEEAAELESELEEAR--EAVEDRREEIEELEEEIEELR 397

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  596 KKETELQMQL------TESLKET-DLLRGQLTKVQAKLSELQETSEQAQSKFKSEK-----QNRK---------QLELKV 654
Cdd:PRK02224  398 ERFGDAPVDLgnaedfLEELREErDELREREAELEATLRTARERVEEAEALLEAGKcpecgQPVEgsphvetieEDRERV 477

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  655 TSLEEELTDLRVEKESLEK----------------NLSERKKKSAQERSQAEEEIDEiRKSYQEELDKLRQLLKKTRVST 718
Cdd:PRK02224  478 EELEAELEDLEEEVEEVEErleraedlveaedrieRLEERREDLEELIAERRETIEE-KRERAEELRERAAELEAEAEEK 556

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  719 DQAAAEQLSLVQAELQTQweAKCEHLLASAKD--EHLQQYQEVCAQRDAYQQKLVQLQEKclalQAQITALTKQNEQHIK 796
Cdd:PRK02224  557 REAAAEAEEEAEEAREEV--AELNSKLAELKEriESLERIRTLLAAIADAEDEIERLREK----REALAELNDERRERLA 630

                         410       420
                  ....*....|....*....|....
gi 578817221  797 ELEKNKSQMSG------VEAAASD 814
Cdd:PRK02224  631 EKRERKRELEAefdearIEEARED 654

PRK11281

mechanosensitive channel MscK;

498-737

2.76e-06

mechanosensitive channel MscK;

Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 51.84 E-value: 2.76e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  498 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERN-----QRY----VEQSNLMMEKRNNSLQTATE-----NTQARV 563
Cdd:PRK11281   74 KIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNdeetrETLstlsLRQLESRLAQTLDQLQNAQNdlaeyNSQLVS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  564 LHAEQEKAKVteELAAATAQVSHL--QLKMTAHQKKET--ELQMQLTESLKETDLLRGQLTKVQAKLSELQETsEQAQSK 639
Cdd:PRK11281  154 LQTQPERAQA--ALYANSQRLQQIrnLLKGGKVGGKALrpSQRVLLQAEQALLNAQNDLQRKSLEGNTQLQDL-LQKQRD 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  640 FKSEKQNRkqlelkvtsLEEELTDLRvekESL-EKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVST 718
Cdd:PRK11281  231 YLTARIQR---------LEHQLQLLQ---EAInSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQRLLKAT 298

                         250       260
                  ....*....|....*....|
gi 578817221  719 DQAAaeqlSLVQAELQT-QW 737
Cdd:PRK11281  299 EKLN----TLTQQNLRVkNW 314

HOOK

pfam05622

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...

600-797

2.86e-06

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.

Pssm-ID: 461694 [Multi-domain] Cd Length: 528 Bit Score: 51.23 E-value: 2.86e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   600 ELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLElkvtSLEEEL-------TDLRVEKESLE 672
Cdd:pfam05622   18 ELDQQVSLLQEEKNSLQQENKKLQERLDQLESGDDSGTPGGKKYLLLQKQLE----QLQEENfrletarDDYRIKCEELE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   673 KNLSERK------KKSAQERSQAEEEIDEIRKS-------------YQEELDKLRQLLKKTRVSTDQAAaeqlSLVQAEL 733
Cdd:pfam05622   94 KEVLELQhrneelTSLAEEAQALKDEMDILRESsdkvkkleatvetYKKKLEDLGDLRRQVKLLEERNA----EYMQRTL 169

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578817221   734 QTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKE 797
Cdd:pfam05622  170 QLEEELKKANALRGQLETYKRQVQELHGKLSEESKKADKLEFEYKKLEEKLEALQKEKERLIIE 233

CALCOCO1

pfam07888

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...

462-797

3.55e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.

Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 51.05 E-value: 3.55e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   462 MDHLMTKVEELQKHSAGNSML--IPSMSVtmetsmimsnIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVE 539
Cdd:pfam07888    3 LDELVTLEEESHGEEGGTDMLlvVPRAEL----------LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   540 QSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQmQLTESLKETDLLRgql 619
Cdd:pfam07888   73 RQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELE-EDIKTLTQRVLER--- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   620 tkvQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSER----------------KKKSA 683
Cdd:pfam07888  149 ---ETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRdtqvlqlqdtittltqKLTTA 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   684 QERSQAEEEIDEIRKSYQEEL-------DKLRQLLKKTRVSTDQAAAE----------------QLSLVQAELQTQWEAK 740
Cdd:pfam07888  226 HRKEAENEALLEELRSLQERLnaserkvEGLGEELSSMAAQRDRTQAElhqarlqaaqltlqlaDASLALREGRARWAQE 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   741 CEHLLASAKDEH---------LQQYQEVCAQRDAYQQKL------------VQLQEKCLALQ---AQITALTKQNEQHIK 796
Cdd:pfam07888  306 RETLQQSAEADKdrieklsaeLQRLEERLQEERMEREKLevelgrekdcnrVQLSESRRELQelkASLRVAQKEKEQLQA 385


                   .
gi 578817221   797 E 797
Cdd:pfam07888  386 E 386

HCR

pfam07111

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...

499-860

3.99e-06

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.

Pssm-ID: 284517 [Multi-domain] Cd Length: 749 Bit Score: 51.29 E-value: 3.99e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   499 IQRIIQENERLKQEI-------LEKSNRIEEQNDKISEL-IERNQRYVEQSNLM-------MEKRNNSLQTATENTQARV 563
Cdd:pfam07111   68 ISRQLQELRRLEEEVrllretsLQQKMRLEAQAMELDALaVAEKAGQAEAEGLRaalagaeMVRKNLEEGSQRELEEIQR 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   564 LHAEQEKAKVT---EELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLsELQET-------- 632
Cdd:pfam07111  148 LHQEQLSSLTQaheEALSSLTSKAEGLEKSLNSLETKRAGEAKQLAEAQKEAELLRKQLSKTQEEL-EAQVTlveslrky 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   633 -SEQAQSKFKSE--KQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQ 709
Cdd:pfam07111  227 vGEQVPPEVHSQtwELERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDSLEPEFPKKCRS 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   710 LLKKTRvstDQAAAEQLSLVQAELQTQWEAK-CEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALT 788
Cdd:pfam07111  307 LLNRWR---EKVFALMVQLKAQDLEHRDSVKqLRGQVAELQEQVTSQSQEQAILQRALQDKAAEVEVERMSAKGLQMELS 383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   789 KQNEQHIKELEKNKS---QMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEE--SYNGR---TILGTIMNTIKMVTLQL 860
Cdd:pfam07111  384 RAQEARRRQQQQTASaeeQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNrlSYAVRkvhTIKGLMARKVALAQLRQ 463

mukB

chromosome partition protein MukB;

525-814

4.06e-06

chromosome partition protein MukB;

Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 51.50 E-value: 4.06e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  525 DKISELIERNQRYVeqSNLMMEKRNNslqtATENTQaRVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQ 604
Cdd:PRK04863  257 DLFKHLITESTNYV--AADYMRHANE----RRVHLE-EALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQD 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  605 LtESLKEtdllrgQLTKVQaklselqeTSEQAQskfksEKQNRKQLELkvtsleEELTDLRVEKESLEKNLSERKKKSAQ 684
Cdd:PRK04863  330 Y-QAASD------HLNLVQ--------TALRQQ-----EKIERYQADL------EELEERLEEQNEVVEEADEQQEENEA 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  685 ERSQAEEEIDEIRKS---YQEELDKLR----------QLLKKTRVSTDQA--AAEQLSLVQAELQTQWEAKCEHLLA--- 746
Cdd:PRK04863  384 RAEAAEEEVDELKSQladYQQALDVQQtraiqyqqavQALERAKQLCGLPdlTADNAEDWLEEFQAKEQEATEELLSleq 463

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  747 ------SAKDEHLQQYQEVCA-----QRDAYQQKLVQL-----QEKCLALQAQitaltkQNEQHIKELEKNKSQMSGVEA 810
Cdd:PRK04863  464 klsvaqAAHSQFEQAYQLVRKiagevSRSEAWDVARELlrrlrEQRHLAEQLQ------QLRMRLSELEQRLRQQQRAER 537


                  ....
gi 578817221  811 AASD 814
Cdd:PRK04863  538 LLAE 541

MukB

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...

575-800

4.35e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 51.11 E-value: 4.35e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  575 EELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKV--------QAKLSELQETSEQAQSKFKSEKQN 646
Cdd:COG3096   836 AELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQAnlladetlADRLEELREELDAAQEAQAFIQQH 915

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  647 RKQLELkvtsLEEELTDLRVEKESLEkNLSERKKKSAQERSQAEEEIDEI-----RK---SYQEEL----------DKLR 708
Cdd:COG3096   916 GKALAQ----LEPLVAVLQSDPEQFE-QLQADYLQAKEQQRRLKQQIFALsevvqRRphfSYEDAVgllgensdlnEKLR 990

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  709 QLLK-------KTRVSTDQAAAE--QLSLVQAELQTQWEAKCEhLLASAKDEhLQQY-------QEVCAQ--RDAYQQKL 770
Cdd:COG3096   991 ARLEqaeearrEAREQLRQAQAQysQYNQVLASLKSSRDAKQQ-TLQELEQE-LEELgvqadaeAEERARirRDELHEEL 1068

                         250       260       270
                  ....*....|....*....|....*....|
gi 578817221  771 VQLQEKCLALQAQITALTKQNEQHIKELEK 800
Cdd:COG3096  1069 SQNRSRRSQLEKQLTRCEAEMDSLQKRLRK 1098

sbcc

TIGR00618

exonuclease SbcC; All proteins in this family for which functions are known are part of an ...

567-840

4.36e-06

Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 51.12 E-value: 4.36e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   567 EQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQN 646
Cdd:TIGR00618  179 TQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKK 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   647 RKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQL 726
Cdd:TIGR00618  259 QQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQS 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   727 SL-VQAELQTQWEAKCehllasakdEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSqm 805
Cdd:TIGR00618  339 SIeEQRRLLQTLHSQE---------IHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQR-- 407

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 578817221   806 sgvEAAASDPSEKVKKIMNQVFQSLRREFELEESY 840
Cdd:TIGR00618  408 ---EQATIDTRTSAFRDLQGQLAHAKKQQELQQRY 439

Tropomyosin_1

pfam12718

Tropomyosin like; This family is a set of eukaryotic tropomyosins. Within the yeast Tpm1 and ...

625-744

5.16e-06

Tropomyosin like; This family is a set of eukaryotic tropomyosins. Within the yeast Tpm1 and Tpm2, biochemical and sequence analyses indicate that Tpm2p spans four actin monomers along a filament, whereas Tpm1p spans five. Despite its shorter length, Tpm2p can compete with Tpm1p for binding to F-actin. Over-expression of Tpm2p in vivo alters the axial budding of haploids to a bipolar pattern, and this can be partially suppressed by co-over-expression of Tpm1p. This suggests distinct functions for the two tropomyosins, and indicates that the ratio between them is important for correct morphogenesis. The family also contains higher eukaryote Tpm3 members.

Pssm-ID: 403808 [Multi-domain] Cd Length: 142 Bit Score: 47.30 E-value: 5.16e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   625 KLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRV-------EKESLEKNLSERKKK---SAQERSQA----- 689
Cdd:pfam12718    1 KMNSLKLEAENAQERAEELEEKVKELEQENLEKEQEIKSLTHknqqleeEVEKLEEQLKEAKEKaeeSEKLKTNNenltr 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578817221   690 -----EEEIDEIRKSYQEELDKLRQllkktrvsTDQAAAEQLSLVQAELQT--QWEAKCEHL 744
Cdd:pfam12718   81 kiqllEEELEESDKRLKETTEKLRE--------TDVKAEHLERKVQALEQErdEWEKKYEEL 134

PTZ00121

MAEBL; Provisional

505-943

5.39e-06

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 50.91 E-value: 5.39e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  505 ENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTE--ELAAATA 582
Cdd:PTZ00121 1312 EEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAakKKAEEKK 1391

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  583 QVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQA-----------KLSELQETSEQ---AQSKFKSEKQNRK 648
Cdd:PTZ00121 1392 KADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAdeakkkaeeakKADEAKKKAEEakkAEEAKKKAEEAKK 1471

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  649 QLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE--------EIDEIRKSyqEELDKLRQLLK--KTRVST 718
Cdd:PTZ00121 1472 ADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEakkaeeakKADEAKKA--EEAKKADEAKKaeEKKKAD 1549

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  719 DQAAAEQLSLVQAELQTQWEAKCEH--LLASAKDEHLQQYQEvcaQRDAYQQKLVQLQEKCLALQAQitaltKQNEQHIK 796
Cdd:PTZ00121 1550 ELKKAEELKKAEEKKKAEEAKKAEEdkNMALRKAEEAKKAEE---ARIEEVMKLYEEEKKMKAEEAK-----KAEEAKIK 1621

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  797 --ELEKNKSQMSGVEAAASDPSEKVKKImnqvfQSLRREFEleesyngrtilgtiMNTIKMVTLQllnqqeQEKEESSSE 874
Cdd:PTZ00121 1622 aeELKKAEEEKKKVEQLKKKEAEEKKKA-----EELKKAEE--------------ENKIKAAEEA------KKAEEDKKK 1676

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817221  875 EEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQV--VEEAVPLPPQALTTSQDGHRRKGD 943
Cdd:PTZ00121 1677 AEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELkkAEEENKIKAEEAKKEAEEDKKKAE 1747

PHA03247

large tegument protein UL36; Provisional

883-1096

6.64e-06

large tegument protein UL36; Provisional

Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.71 E-value: 6.64e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  883 RPRRPSQEQsasassgQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGhrRKGDSEAEALSEIKDGSLPPELS 962
Cdd:PHA03247 2907 RPPQPQAPP-------PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE--PSGAVPQPWLGALVPGRVAVPRF 2977

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  963 CIPSHRvlgPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVRE-VAPDGPLQESSTRLSLTSDPEEGDPLA 1041
Cdd:PHA03247 2978 RVPQPA---PSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtLWPPDDTEDSDADSLFDSDSERSDLEA 3054

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578817221 1042 LGPEsPGEPQPPQLKKDDVTSSTGPHKELSSTEAG--STVAGAAL--RPSHHSQRSSLS 1096
Cdd:PHA03247 3055 LDPL-PPEPHDPFAHEPDPATPEAGARESPSSQFGppPLSANAALsrRYVRSTGRSALA 3112

mukB

chromosome partition protein MukB;

507-787

6.68e-06

chromosome partition protein MukB;

Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 50.73 E-value: 6.68e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  507 ERLKQEILEKSNRIEEQN---DKISELIERNQRYVEQSNLMMEKRNNSL---QTATENTQARVL---HAEQ--EKAK--- 572
Cdd:PRK04863  351 ERYQADLEELEERLEEQNevvEEADEQQEENEARAEAAEEEVDELKSQLadyQQALDVQQTRAIqyqQAVQalERAKqlc 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  573 ----------------VTEELAAATAQVSHLQLKMTAHQ--KKETELQMQLTESL-----------KETDLLR------- 616
Cdd:PRK04863  431 glpdltadnaedwleeFQAKEQEATEELLSLEQKLSVAQaaHSQFEQAYQLVRKIagevsrseawdVARELLRrlreqrh 510

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  617 --GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSlEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEid 694
Cdd:PRK04863  511 laEQLQQLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDD-EDELEQLQEELEARLESLSESVSEARERRMALRQQ-- 587

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  695 eirksyQEELDKLRQLLKKTRVS--TDQAAAEQLSlvqaelqtqwEAKCEHLLASAK-DEHLQQYQEvcaQRDAYQQKLV 771
Cdd:PRK04863  588 ------LEQLQARIQRLAARAPAwlAAQDALARLR----------EQSGEEFEDSQDvTEYMQQLLE---RERELTVERD 648

                         330
                  ....*....|....*.
gi 578817221  772 QLQEKCLALQAQITAL 787
Cdd:PRK04863  649 ELAARKQALDEEIERL 664

Myosin_tail_1

pfam01576

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...

504-835

6.69e-06

Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 50.56 E-value: 6.69e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   504 QENERLKQEILEKSNRIEEQNDKISELIERnqryVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQ 583
Cdd:pfam01576  422 SESERQRAELAEKLSKLQSELESVSSLLNE----AEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDE 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   584 VSHL--QLKMTAHQKKETE-----LQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTS 656
Cdd:pfam01576  498 RNSLqeQLEEEEEAKRNVErqlstLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNR 577

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   657 LEEELTDLRVEKESLEKNLS--ERKKKS---------------AQERSQAE------------------------EEIDE 695
Cdd:pfam01576  578 LQQELDDLLVDLDHQRQLVSnlEKKQKKfdqmlaeekaisaryAEERDRAEaeareketralslaraleealeakEELER 657

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   696 IRKSYQEELDKL----------RQLLKKTRVSTDQAAAE---QLSLVQAELQTQWEAK--CEHLLASAKDEHLQQYQevc 760
Cdd:pfam01576  658 TNKQLRAEMEDLvsskddvgknVHELERSKRALEQQVEEmktQLEELEDELQATEDAKlrLEVNMQALKAQFERDLQ--- 734

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   761 AQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHI---KELEKN-KSQMSGVEAAASDPSEKVK--KIMNQVFQSLRREF 834
Cdd:pfam01576  735 ARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVaakKKLELDlKELEAQIDAANKGREEAVKqlKKLQAQMKDLQREL 814


                   .
gi 578817221   835 E 835
Cdd:pfam01576  815 E 815

SlpA

COG1047

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...

126-197

6.75e-06

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440668 [Multi-domain] Cd Length: 138 Bit Score: 47.02 E-value: 6.75e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578817221  126 VEVGDSLEVAYTGWLfqnhVLGQVFDSTANKDKLLrLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVG 197
Cdd:COG1047     1 IEKGDVVTLHYTLKL----EDGEVFDSTFEGEPLE-FLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYG 67

MscS_porin

pfam12795

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...

588-815

6.76e-06

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.

Pssm-ID: 432790 [Multi-domain] Cd Length: 238 Bit Score: 48.84 E-value: 6.76e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   588 QLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQL-------------ELKV 654
Cdd:pfam12795    1 KLDELEKAKLDEAAKKKLLQDLQQALSLLDKIDASKQRAAAYQKALDDAPAELRELRQELAALqakaeaapkeilaSLSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   655 TSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAE---EEIDEIRKsyqeELDKLRQLLKKTRVSTDQAAAEQLSLVQA 731
Cdd:pfam12795   81 EELEQRLLQTSAQLQELQNQLAQLNSQLIELQTRPEraqQQLSEARQ----RLQQIRNRLNGPAPPGEPLSEAQRWALQA 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   732 ELQtqweakcehlLASAKDEHLQQYQEVC--------AQRDAYQQKLVQLQEKCLALQAQItaltkqNEQHIKELEKN-- 801
Cdd:pfam12795  157 ELA----------ALKAQIDMLEQELLSNnnrqdllkARRDLLTLRIQRLEQQLQALQELL------NEKRLQEAEQAva 220

                          250
                   ....*....|....
gi 578817221   802 KSQMSGVEAAASDP 815
Cdd:pfam12795  221 QTEQLAEEAAGDHP 234

CAGE1

pfam15066

Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in ...

510-690

7.95e-06

Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues. CAGE-1 is predominantly expressed during post-meiotic stages. It localizes to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa.

Pssm-ID: 464481 Cd Length: 528 Bit Score: 49.83 E-value: 7.95e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   510 KQEIL-EKSNRIEEqndKISELIErnqryvEQSNLMMEKR--NNSLQTATE---NTQARVLHAEQEKAKVTEELAAATAQ 583
Cdd:pfam15066  357 KQQVFvDIINKLKE---NVEELIE------DKYNVILEKNdiNKTLQNLQEilaNTQKHLQESRKEKETLQLELKKIKVN 427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   584 VSHLQLK-MTAHQKKETE----LQMQLTESLKETDLLRGQLTKvqaklSELQETSEQAQSKFKSEKQNRKQLELkvtSLE 658
Cdd:pfam15066  428 YVHLQERyITEMQQKNKSvsqcLEMDKTLSKKEEEVERLQQLK-----GELEKATTSALDLLKREKETREQEFL---SLQ 499

                          170       180       190
                   ....*....|....*....|....*....|...
gi 578817221   659 EELTdlRVEKESLEknlsERKK-KSAQERSQAE 690
Cdd:pfam15066  500 EEFQ--KHEKENLE----ERQKlKSRLEKLVAQ 526

TPR_MLP1_2

pfam07926

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...

596-711

8.93e-06

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.

Pssm-ID: 462316 [Multi-domain] Cd Length: 129 Bit Score: 46.09 E-value: 8.93e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   596 KKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQN----RKQL-ELK--VTSLEEELTDLRVEK 668
Cdd:pfam07926    1 AELSSLQSEIKRLKEEAADAEAQLQKLQEDLEKQAEIAREAQQNYERELVLhaedIKALqALReeLNELKAEIAELKAEA 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 578817221   669 ESLEKNLSERKKKSAQERSQAEEEIDEIRKSYqEELDKLRQLL 711
Cdd:pfam07926   81 ESAKAELEESEESWEEQKKELEKELSELEKRI-EDLNEQNKLL 122

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

624-821

1.40e-05

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 49.68 E-value: 1.40e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   624 AKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK--NLSERKKK-------------------- 681
Cdd:TIGR02169  163 AGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERyqALLKEKREyegyellkekealerqkeai 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   682 ----SAQERSQA--EEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAA---EQLSLVQAELqtqweAKCEHLLASAKDEH 752
Cdd:TIGR02169  243 erqlASLEEELEklTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLrvkEKIGELEAEI-----ASLERSIAEKEREL 317

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578817221   753 LQ---QYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKK 821
Cdd:TIGR02169  318 EDaeeRLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKD 389

MukB

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...

443-811

1.41e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 49.57 E-value: 1.41e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  443 EARQhntEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEE 522
Cdd:COG3096   289 ELRR---ELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAASDHLNLVQTALRQQEKIERYQEDLEELTERLEE 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  523 QNDKISELIERNQRYVEQSNLmMEKRNNSL-------QTATENTQARVLHAEQ-----EKAK------------VTEELA 578
Cdd:COG3096   366 QEEVVEEAAEQLAEAEARLEA-AEEEVDSLksqladyQQALDVQQTRAIQYQQavqalEKARalcglpdltpenAEDYLA 444

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  579 AATAQVSHL---------QLKMTAHQKKETELQMQLTESL-----------KETDLLR---------GQLTKVQAKLSEL 629
Cdd:COG3096   445 AFRAKEQQAteevleleqKLSVADAARRQFEKAYELVCKIageversqawqTARELLRryrsqqalaQRLQQLRAQLAEL 524

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  630 QETSEQAQSKFKSEKQNRKQLELKVTSlEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEeldkLRQ 709
Cdd:COG3096   525 EQRLRQQQNAERLLEEFCQRIGQQLDA-AEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKE----LAA 599

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  710 LLKKTRVStdQAAAEQLslvqaelqtqweakCEHLlasakDEHLQQYQEVcaqrDAYQQKLVQLQEKCLALQAQITALTK 789
Cdd:COG3096   600 RAPAWLAA--QDALERL--------------REQS-----GEALADSQEV----TAAMQQLLEREREATVERDELAARKQ 654

                         410       420
                  ....*....|....*....|..
gi 578817221  790 QNEQHIKELeknkSQMSGVEAA 811
Cdd:COG3096   655 ALESQIERL----SQPGGAEDP 672

PRK02224

DNA double-strand break repair Rad50 ATPase;

503-708

1.57e-05

DNA double-strand break repair Rad50 ATPase;

Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 49.27 E-value: 1.57e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  503 IQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQsnlmmEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATA 582
Cdd:PRK02224  470 IEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEA-----EDRIERLEERREDLEELIAERRETIEEKRERAEELRE 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  583 QVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQ------AKLSELQETSEQAQSKFKSEKQNRKQLELKVTS 656
Cdd:PRK02224  545 RAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKerieslERIRTLLAAIADAEDEIERLREKREALAELNDE 624

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578817221  657 LEEELTDLRVEKESLEKNLSERKKKSAQERSQ-AEEEIDEIrksyQEELDKLR 708
Cdd:PRK02224  625 RRERLAEKRERKRELEAEFDEARIEEAREDKErAEEYLEQV----EEKLDELR 673

DUF4618

pfam15397

Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins ...

620-819

1.82e-05

Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.

Pssm-ID: 464704 [Multi-domain] Cd Length: 258 Bit Score: 47.64 E-value: 1.82e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   620 TKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKEsleknlSERKKKSAQeRSQAEEEIDEIRKS 699
Cdd:pfam15397   63 KQLQQAKAELQEWEEKEESKLNKLEQQLEQLNAKIQKTQEELNFLSTYKD------KEYPVKAVQ-IANLVRQLQQLKDS 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   700 YQEELDKLRQLLKKTRvstdqaaaeqlslvqAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLvqlqEKCLA 779
Cdd:pfam15397  136 QQDELDELEEMRRMVL---------------ESLSRKIQKKKEKILSSLAEKTLSPYQESLLQKTRDNQVM----LKEIE 196

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 578817221   780 lqaqitaltkQNEQHIKELEKN----KSQMSGVEAAASDPSEKV 819
Cdd:pfam15397  197 ----------QFREFIDELEEEipklKAEVQQLQAQRQEPREVI 230

mukB

chromosome partition protein MukB;

507-805

2.37e-05

chromosome partition protein MukB;

Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 48.80 E-value: 2.37e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  507 ERLKQEIleksNRIEEQNDKISELIERNQRYVEQSNLMMekrNNSLQTATEntqarvlhAEQEkakvtEELAAATAQVSH 586
Cdd:PRK04863  789 EQLRAER----EELAERYATLSFDVQKLQRLHQAFSRFI---GSHLAVAFE--------ADPE-----AELRQLNRRRVE 848

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  587 LQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKV--------QAKLSELQETSEQAQSKFKSEKQNRKQLELkvtsLE 658
Cdd:PRK04863  849 LERALADHESQEQQQRSQLEQAKEGLSALNRLLPRLnlladetlADRVEEIREQLDEAEEAKRFVQQHGNALAQ----LE 924

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  659 EELTDLRVEKESLEK-----NLSERKKKSAQERSQAEEEIDEIRK--SYQEEL----------DKLRQLLK--------- 712
Cdd:PRK04863  925 PIVSVLQSDPEQFEQlkqdyQQAQQTQRDAKQQAFALTEVVQRRAhfSYEDAAemlaknsdlnEKLRQRLEqaeqertra 1004

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  713 KTRVSTDQAAAEQLSLVQAELQTQWEAKCEhLLASAKDEhLQQY---------QEVCAQRDAYQQKLVQLQEKCLALQAQ 783
Cdd:PRK04863 1005 REQLRQAQAQLAQYNQVLASLKSSYDAKRQ-MLQELKQE-LQDLgvpadsgaeERARARRDELHARLSANRSRRNQLEKQ 1082

                         330       340
                  ....*....|....*....|....*.
gi 578817221  784 IT----ALTKQNEQhIKELEKNKSQM 805
Cdd:PRK04863 1083 LTfceaEMDNLTKK-LRKLERDYHEM 1107

235kDa-fam

TIGR01612

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...

450-715

2.80e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.

Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 48.51 E-value: 2.80e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   450 EIRMAVSKVADKMDHLMTKVEELQKHSAG--NSM--LIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQND 525
Cdd:TIGR01612 1115 KIKDDIKNLDQKIDHHIKALEEIKKKSENyiDEIkaQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKKNIYDEIKK 1194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   526 KISELIErnqryVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAAtaqvshlqlkMTAHQKKETELQMQL 605
Cdd:TIGR01612 1195 LLNEIAE-----IEKDKTSLEEVKGINLSYGKNLGKLFLEKIDEEKKKSEHMIKA----------MEAYIEDLDEIKEKS 1259

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   606 TESLKETdllrGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLE------LKVTSLEEELTDLRVEKESLEKNLSERK 679
Cdd:TIGR01612 1260 PEIENEM----GIEMDIKAEMETFNISHDDDKDHHIISKKHDENISdireksLKIIEDFSEESDINDIKKELQKNLLDAQ 1335

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817221   680 KKSAQ-------------------------ERSQAEEEIDEIRKSYQEELDKLRQLLKKTR 715
Cdd:TIGR01612 1336 KHNSDinlylneianiynilklnkikkiidEVKEYTKEIEENNKNIKDELDKSEKLIKKIK 1396

rad50

TIGR00606

rad50; All proteins in this family for which functions are known are involvedin recombination, ...

446-838

2.83e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).

Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 48.50 E-value: 2.83e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   446 QHNTEIRMAVSKVADKMDHLMTKVEELQ-----KHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRI 520
Cdd:TIGR00606  688 QTEAELQEFISDLQSKLRLAPDKLKSTEselkkKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDI 767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   521 EEQ---------NDKISELIERNQRYVEQsnLMMEKRNNSLQTATENTQAR-------VLHAEQEKAKVTEELAAATAQV 584
Cdd:TIGR00606  768 EEQetllgtimpEEESAKVCLTDVTIMER--FQMELKDVERKIAQQAAKLQgsdldrtVQQVNQEKQEKQHELDTVVSKI 845

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   585 SHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQlelkVTSLEEELTDL 664
Cdd:TIGR00606  846 ELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQ----DSPLETFLEKD 921

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   665 RVEKESLEKNLSERKKKSAQERSQAEEEIDEI---RKSYQEELDKLRQLLKKTRVSTDQAAAEQLSlvqaELQTQWEAKC 741
Cdd:TIGR00606  922 QQEKEELISSKETSNKKAQDKVNDIKEKVKNIhgyMKDIENKIQDGKDDYLKQKETELNTVNAQLE----ECEKHQEKIN 997

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   742 EHLLASAKDEHLQQYQEvcaqrdayqqKLVQLQEKCLALQAQITALTKQNEQHIKELekNKSQMSGVEAAASDPSEKVKK 821
Cdd:TIGR00606  998 EDMRLMRQDIDTQKIQE----------RWLQDNLTLRKRENELKEVEEELKQHLKEM--GQMQVLQMKQEHQKLEENIDL 1065

                          410
                   ....*....|....*..
gi 578817221   822 IMNQVFQSLRREFELEE 838
Cdd:TIGR00606 1066 IKRNHVLALGRQKGYEK 1082

HOOK

pfam05622

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...

595-786

3.00e-05

Pssm-ID: 461694 [Multi-domain] Cd Length: 528 Bit Score: 48.15 E-value: 3.00e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   595 QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQ---ETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESL 671
Cdd:pfam05622  303 RERLTELQQLLEDANRRKNELETQNRLANQRILELQqqvEELQKALQEQGSKAEDSSLLKQKLEEHLEKLHEAQSELQKK 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   672 EKNLSERKKKSAQERSQAEEEIDEIRKSYQEE-----------LDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQwEAK 740
Cdd:pfam05622  383 KEQIEELEPKQDSNLAQKIDELQEALRKKDEDmkameerykkyVEKAKSVIKTLDPKQNPASPPEIQALKNQLLEK-DKK 461

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817221   741 CEHLLASAKDEHLQQYQE------------VCAQRDAYQQKLVQLQ---EKCLALQAQITA 786
Cdd:pfam05622  462 IEHLERDFEKSKLQREQEeklivtawynmgMALHRKAIEERLAGLSspgQSFLARQRQATN 522

TPR_MLP1_2

pfam07926

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...

566-688

4.13e-05

Pssm-ID: 462316 [Multi-domain] Cd Length: 129 Bit Score: 44.55 E-value: 4.13e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   566 AEQEKAKVTEELAAATAQVSHLQLKM--------TAHQKKETELQMQlTESLKETDLLRGQLTKVQAKLSELQETSEQAQ 637
Cdd:pfam07926    6 LQSEIKRLKEEAADAEAQLQKLQEDLekqaeiarEAQQNYERELVLH-AEDIKALQALREELNELKAEIAELKAEAESAK 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578817221   638 SKFKSEKQnrkqlelkvtSLEEEltdlrveKESLEKNLSERKKKSAQERSQ 688
Cdd:pfam07926   85 AELEESEE----------SWEEQ-------KKELEKELSELEKRIEDLNEQ 118

TACC_C

pfam05010

Transforming acidic coiled-coil-containing protein (TACC), C-terminal; This entry represents a ...

507-713

4.89e-05

Transforming acidic coiled-coil-containing protein (TACC), C-terminal; This entry represents a C-terminal domain found in the the proteins TACC 1, 2 and 3 (TACC1-3). TACC1 is found concentrated in the centrosomes of eukaryotes which may play a conserved role in organizing centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1). TACC 3 from Xenopus laevis, also known as maskin, associates XMAP215 and promotes efficient microtubule elongation during mitosis. Maskin is also found to bind CPEB and elF-4E. Interestingly, the functional homolog (Alp7) in Schizosaccharomyces pombe (not included in this entry) has been shown to be required for organization of bipolar spindles.

Pssm-ID: 461517 [Multi-domain] Cd Length: 201 Bit Score: 45.82 E-value: 4.89e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   507 ERLKQEILEKSNRIEEQNDKISELIErnqryveqsnlmmekrnnslqtatENTQARVLHAEQEKAkvteelaaataqVSH 586
Cdd:pfam05010   11 EKARNEIEEKELEINELKAKYEELRR------------------------ENLEMRKIVAEFEKT------------IAQ 54

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   587 LqlkMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEeltdlRV 666
Cdd:pfam05010   55 M---IEEKQKQKELEHAEIQKVLEEKDQALADLNSVEKSFSDLFKRYEKQKEVISGYKKNEESLKKCAQDYLA-----RI 126

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 578817221   667 EKEslEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK 713
Cdd:pfam05010  127 KKE--EQRYQALKAHAEEKLDQANEEIAQVRSKAKAETAALQASLRK 171

HMMR_N

pfam15905

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...

508-800

5.20e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.

Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 46.73 E-value: 5.20e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   508 RLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAataqvshl 587
Cdd:pfam15905   55 KVKSLELKKKSQKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVAS-------- 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   588 qlkmtahqkketeLQMQLTESLKETDLLRGQLT------KVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEEL 661
Cdd:pfam15905  127 -------------LEKQLLELTRVNELLKAKFSedgtqkKMSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNL 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   662 TDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRK--SYQEELDKLRQLLKKTRVSTDQAAAEQLSlvqaeLQTQWEA 739
Cdd:pfam15905  194 EHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITElsCVSEQVEKYKLDIAQLEELLKEKNDEIES-----LKQSLEE 268

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221   740 KCEHLLASAKD--EHLQQYQEvcaqrdAYQQKLVQLQEKCLALQAQITALTK---QNEQHIKELEK 800
Cdd:pfam15905  269 KEQELSKQIKDlnEKCKLLES------EKEELLREYEEKEQTLNAELEELKEkltLEEQEHQKLQQ 328

PRK00106

ribonuclease Y;

563-732

7.14e-05

ribonuclease Y;

Pssm-ID: 178867 [Multi-domain] Cd Length: 535 Bit Score: 46.79 E-value: 7.14e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  563 VLHAEQEKAKVTEELAAATAQvshlQLKMTAHQKKETELQMQLTESLKETDLLRGQLTkVQAKlSELQETSEQAQSKFKS 642
Cdd:PRK00106   21 LISIKMKSAKEAAELTLLNAE----QEAVNLRGKAERDAEHIKKTAKRESKALKKELL-LEAK-EEARKYREEIEQEFKS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  643 EKQNRKQLELKVT----SL---EEELTDLRVEKESLEKNLSErKKKSAQERsqaEEEIDEIRKSYQEELDKLRQLlkktr 715
Cdd:PRK00106   95 ERQELKQIESRLTeratSLdrkDENLSSKEKTLESKEQSLTD-KSKHIDER---EEQVEKLEEQKKAELERVAAL----- 165

                         170
                  ....*....|....*..
gi 578817221  716 vstDQAAAEQLSLVQAE 732
Cdd:PRK00106  166 ---SQAEAREIILAETE 179

CwlO1

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...

495-691

7.16e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];

Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 46.36 E-value: 7.16e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISEL---IERNQRYVEQSNLMMEKRNNSLQT--ATENTQARVLHAeqe 569
Cdd:COG3883    35 AQAELDALQAELEELNEEYNELQAELEALQAEIDKLqaeIAEAEAEIEERREELGERARALYRsgGSVSYLDVLLGS--- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  570 kakvtEELAAATAQVSHLQlKMTAHQKKETELQMQLTESLKET-DLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRK 648
Cdd:COG3883   112 -----ESFSDFLDRLSALS-KIADADADLLEELKADKAELEAKkAELEAKLAELEALKAELEAAKAELEAQQAEQEALLA 185

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 578817221  649 QLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE 691
Cdd:COG3883   186 QLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAA 228

PRK10246

exonuclease subunit SbcC; Provisional

501-812

7.50e-05

exonuclease subunit SbcC; Provisional

Pssm-ID: 182330 [Multi-domain] Cd Length: 1047 Bit Score: 47.10 E-value: 7.50e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  501 RIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEkrnnsLQTATENtQARVLHAEQEKAKV------- 573
Cdd:PRK10246  434 QIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLAD-----VKTICEQ-EARIKDLEAQRAQLqagqpcp 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  574 ----TEELAAATAQVshlqLKMTAHQKKETELQMQLTESLKETDLLRGQLtkvQAKLSELQETSEQAQSKFKSEKQNRKQ 649
Cdd:PRK10246  508 lcgsTSHPAVEAYQA----LEPGVNQSRLDALEKEVKKLGEEGAALRGQL---DALTKQLQRDESEAQSLRQEEQALTQQ 580

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  650 LELKVTSL------EEELTDLRVEKESLEKNL---SERKKKSAQERSQAEEEIdeirkSYQEELDKLRQLLkktrvsTDQ 720
Cdd:PRK10246  581 WQAVCASLnitlqpQDDIQPWLDAQEEHERQLrllSQRHELQGQIAAHNQQII-----QYQQQIEQRQQQL------LTA 649

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  721 AAAEQLSLVQAELQTQWeakcehllASAKDEHLQQYQEVCAQRDAYQQKLVQLQ-------------------------- 774
Cdd:PRK10246  650 LAGYALTLPQEDEEASW--------LATRQQEAQSWQQRQNELTALQNRIQQLTplletlpqsddlphseetvaldnwrq 721

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 578817221  775 --EKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAA 812
Cdd:PRK10246  722 vhEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQFDTALQAS 761

MukB

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...

628-831

7.63e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 47.25 E-value: 7.63e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  628 ELQETSEQ-AQSKFKSEKQNR--KQLELKVTSL---------EEELTDLRVEKESLEKNLSERKKKSAQERSQAEeeide 695
Cdd:COG3096   793 ERDELAEQyAKASFDVQKLQRlhQAFSQFVGGHlavafapdpEAELAALRQRRSELERELAQHRAQEQQLRQQLD----- 867

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  696 irkSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAK------CEHLlaSAKDEHLQQYQEVCAQRDAYQQK 769
Cdd:COG3096   868 ---QLKEQLQLLNKLLPQANLLADETLADRLEELREELDAAQEAQafiqqhGKAL--AQLEPLVAVLQSDPEQFEQLQAD 942

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  770 LVQLQEKCLALQAQITALTK--QNEQHI------------KEL-EKNKSQMSGVEAAASDPSEKVKKI------MNQVFQ 828
Cdd:COG3096   943 YLQAKEQQRRLKQQIFALSEvvQRRPHFsyedavgllgenSDLnEKLRARLEQAEEARREAREQLRQAqaqysqYNQVLA 1022


                  ...
gi 578817221  829 SLR 831
Cdd:COG3096  1023 SLK 1025

CwlO1

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...

635-821

1.01e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];

Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 45.98 E-value: 1.01e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  635 QAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK---NLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLL 711
Cdd:COG3883    13 FADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEeynELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  712 K---KTRVSTD-----------QAAAEQLSLV-------QAELQTQWEAKCEhlLASAKDEHLQQYQEVCAQRDAYQQKL 770
Cdd:COG3883    93 RalyRSGGSVSyldvllgsesfSDFLDRLSALskiadadADLLEELKADKAE--LEAKKAELEAKLAELEALKAELEAAK 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578817221  771 VQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKK 821
Cdd:COG3883   171 AELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221

COG4372

Uncharacterized protein, contains DUF3084 domain [Function unknown];

499-740

1.07e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];

Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 46.05 E-value: 1.07e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  499 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRyveqsnlmMEKRNNSLQTATENTQARVLHAEQEKAKVTEELA 578
Cdd:COG4372    61 LEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQ--------AQEELESLQEEAEELQEELEELQKERQDLEQQRK 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  579 AATAQVSHLQLKMTAHQKKETELQMQLTEslketdlLRGQLTKVQAKLSELQEtsEQAQSKFKSEKQNRKQLELKVTSLE 658
Cdd:COG4372   133 QLEAQIAELQSEIAEREEELKELEEQLES-------LQEELAALEQELQALSE--AEAEQALDELLKEANRNAEKEEELA 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  659 EELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWE 738
Cdd:COG4372   204 EAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAAL 283


                  ..
gi 578817221  739 AK 740
Cdd:COG4372   284 EL 285

DUF4670

pfam15709

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...

618-758

1.08e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.

Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 46.10 E-value: 1.08e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   618 QLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEE--LTDLRVEKESLEKNLSERKK----KSAQERSQAEE 691
Cdd:pfam15709  346 RRLEVERKRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEirLRKQRLEEERQRQEEEERKQrlqlQAAQERARQQQ 425

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   692 EidEIRKSYQEeldkLRQllKKTRVSTDQAAAEQLSlvQAELQTQWEAKCEHLLASAKD---EHLQQYQE 758
Cdd:pfam15709  426 E--EFRRKLQE----LQR--KKQQEEAERAEAEKQR--QKELEMQLAEEQKRLMEMAEEerlEYQRQKQE 485

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

497-709

1.23e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 46.45 E-value: 1.23e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  497 SNIQRIiqenERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNL--------MMEKRNNSLQTATENTQAR------ 562
Cdd:COG4913   607 DNRAKL----AALEAELAELEEELAEAEERLEALEAELDALQERREAlqrlaeysWDEIDVASAEREIAELEAElerlda 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  563 ----VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESlkETDLLRGQLTKVQAKLSELQETSEQAQS 638
Cdd:COG4913   683 ssddLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDEL--QDRLEAAEDLARLELRALLEERFAAALG 760

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817221  639 KfKSEKQNRKQLELKVTSLEEELTDLRvekESLEKNLSERKKKSAQERSQAEEEIDEIRkSYQEELDKLRQ 709
Cdd:COG4913   761 D-AVERELRENLEERIDALRARLNRAE---EELERAMRAFNREWPAETADLDADLESLP-EYLALLDRLEE 826

Mitofilin

pfam09731

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...

563-817

1.26e-04

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.

Pssm-ID: 430783 [Multi-domain] Cd Length: 618 Bit Score: 46.29 E-value: 1.26e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   563 VLHAEQEKAKVTE--ELAAATAQVSHLQLKmtahqKKETELQMQLTE-SLKETDLLRGQLTKVQAKLSELQEtsEQAQSK 639
Cdd:pfam09731  235 VEKAQSLAKLVDQykELVASERIVFQQELV-----SIFPDIIPVLKEdNLLSNDDLNSLIAHAHREIDQLSK--KLAELK 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   640 fkseKQNRKQLELKVTSLEEELTDLRVE-KESLEKNLSERKKksaQERSQAEEEIDEIRKSYQEELdklrqllkktrvst 718
Cdd:pfam09731  308 ----KREEKHIERALEKQKEELDKLAEElSARLEEVRAADEA---QLRLEFEREREEIRESYEEKL-------------- 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   719 dqaaaeqlslvQAELQTQWEAKCEHLlasaKDEHLQQYQEvcaqrdayqqklvqLQEKclALQAQITALTKQNEQHIKEL 798
Cdd:pfam09731  367 -----------RTELERQAEAHEEHL----KDVLVEQEIE--------------LQRE--FLQDIKEKVEEERAGRLLKL 415

                          250
                   ....*....|....*....
gi 578817221   799 EKNKSQMSGVEAAASDPSE 817
Cdd:pfam09731  416 NELLANLKGLEKATSSHSE 434

GAS

pfam13851

Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...

501-707

1.35e-04

Pssm-ID: 464001 [Multi-domain] Cd Length: 200 Bit Score: 44.13 E-value: 1.35e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   501 RIIQENERLKQEILEKSNRIEEQN-DKI----SELIERNQRYVEQSNLMMEkrnnslqtatentqarvlhAEQEKAKVTE 575
Cdd:pfam13851    1 ELMKNHEKAFNEIKNYYNDITRNNlELIkslkEEIAELKKKEERNEKLMSE-------------------IQQENKRLTE 61

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   576 ELAAATAQVSHLQLKMTAHQK----------KETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQS--KFKSE 643
Cdd:pfam13851   62 PLQKAQEEVEELRKQLENYEKdkqslknlkaRLKVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAAIQdvQQKTG 141

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578817221   644 KQNRkQLELKVTSLEEELtdlrvekESLEKNLSERKKKS---AQERSQAEEEIDEIRKSYQEELDKL 707
Cdd:pfam13851  142 LKNL-LLEKKLQALGETL-------EKKEAQLNEVLAAAnldPDALQAVTEKLEDVLESKNQLIKDL 200

Filament

pfam00038

Intermediate filament protein;

514-709

1.43e-04

Intermediate filament protein;

Pssm-ID: 459643 [Multi-domain] Cd Length: 313 Bit Score: 45.30 E-value: 1.43e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   514 LEKSNRIEEQND----KISELIERNQRYVEQSNLMMEK-----RNNSLQTATENTQARV------LHAEQEKAKVTEELA 578
Cdd:pfam00038   17 IDKVRFLEQQNKlletKISELRQKKGAEPSRLYSLYEKeiedlRRQLDTLTVERARLQLeldnlrLAAEDFRQKYEDELN 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   579 -----------------AATAQVSHLQLKMTA-----------HQKKETELQMQLTES--LKETDLLRGQ-LTKV----- 622
Cdd:pfam00038   97 lrtsaendlvglrkdldEATLARVDLEAKIESlkeelaflkknHEEEVRELQAQVSDTqvNVEMDAARKLdLTSAlaeir 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   623 ------------------QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQ 684
Cdd:pfam00038  177 aqyeeiaaknreeaeewyQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKASLERQLAETEERYEL 256

                          250       260
                   ....*....|....*....|....*
gi 578817221   685 ERSQAEEEIDEIrksyQEELDKLRQ 709
Cdd:pfam00038  257 QLADYQELISEL----EAELQETRQ 277

FPP

pfam05911

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...

512-686

1.54e-04

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.

Pssm-ID: 461778 [Multi-domain] Cd Length: 859 Bit Score: 45.82 E-value: 1.54e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   512 EILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN---TQARVLHAEQEKAKVTEELAAATaqvshlQ 588
Cdd:pfam05911  664 EIPSDGPLVSGSNDLKTEENKRLKEEFEQLKSEKENLEVELASCTENlesTKSQLQESEQLIAELRSELASLK------E 737

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   589 LKMTAhqkkETELQMQlTESLKETDLlrgQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTdlRVEK 668
Cdd:pfam05911  738 SNSLA----ETQLKCM-AESYEDLET---RLTELEAELNELRQKFEALEVELEEEKNCHEELEAKCLELQEQLE--RNEK 807

                          170
                   ....*....|....*....
gi 578817221   669 ESLEKNL-SERKKKSAQER 686
Cdd:pfam05911  808 KESSNCDaDQEDKKLQQEK 826

ATG16

pfam08614

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...

529-707

1.58e-04

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.

Pssm-ID: 462536 [Multi-domain] Cd Length: 176 Bit Score: 43.77 E-value: 1.58e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   529 ELIERNQRYVEQSNLMmEKRNNSLQTATEN-TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTE 607
Cdd:pfam08614    4 ELIDAYNRLLDRTALL-EAENAKLQSEPESvLPSTSSSKLSKASPQSASIQSLEQLLAQLREELAELYRSRGELAQRLVD 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   608 slketdllrgqltkVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEEL-------TDLRVEKESLekNLserkk 680
Cdd:pfam08614   83 --------------LNEELQELEKKLREDERRLAALEAERAQLEEKLKDREEELrekrklnQDLQDELVAL--QL----- 141

                          170       180
                   ....*....|....*....|....*..
gi 578817221   681 ksaqERSQAEEEIDEIRKSYQEELDKL 707
Cdd:pfam08614  142 ----QLNMAEEKLRKLEKENRELVERW 164

rad50

TIGR00606

rad50; All proteins in this family for which functions are known are involvedin recombination, ...

582-746

1.62e-04

Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 46.19 E-value: 1.62e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   582 AQVSHLQLKMTAHQK-KETELQMQLTESLKETDL-LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLE---LKVTS 656
Cdd:TIGR00606  187 ALETLRQVRQTQGQKvQEHQMELKYLKQYKEKACeIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEhnlSKIMK 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   657 LEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIR-------KSYQEELDKLRQLLKKTRVSTDQAAAEQLSLV 729
Cdd:TIGR00606  267 LDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYhnhqrtvREKERELVDCQRELEKLNKERRLLNQEKTELL 346

                          170
                   ....*....|....*....
gi 578817221   730 --QAELQTQWEAKCEHLLA 746
Cdd:TIGR00606  347 veQGRLQLQADRHQEHIRA 365

Macoilin

pfam09726

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...

582-789

1.77e-04

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.

Pssm-ID: 462859 [Multi-domain] Cd Length: 670 Bit Score: 45.61 E-value: 1.77e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   582 AQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKvtsLEEEl 661
Cdd:pfam09726  402 QDIKKLKAELQASRQTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLEKR---LKAE- 477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   662 tdlRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQllkktrvstdqaAAEQLSLVQAELQTQWEAKC 741
Cdd:pfam09726  478 ---QEARASAEKQLAEEKKRKKEEEATAARAVALAAASRGECTESLKQ------------RKRELESEIKKLTHDIKLKE 542

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 578817221   742 EHLLA-SAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 789
Cdd:pfam09726  543 EQIRElEIKVQELRKYKESEKDTEVLMSALSAMQDKNQHLENSLSAETR 591

PTZ00121

MAEBL; Provisional

443-936

1.79e-04

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.90 E-value: 1.79e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  443 EARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEK---SNR 519
Cdd:PTZ00121 1312 EEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKkaeEKK 1391

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  520 IEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQ-LKMTAHQKKE 598
Cdd:PTZ00121 1392 KADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEeAKKKAEEAKK 1471

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  599 TELQMQLTESLKETDLLRGQLTKVQAKLSELQETSE---------QAQSKFKSEK-----QNRKQLELKVTSLEEELTDL 664
Cdd:PTZ00121 1472 ADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEakkkadeakKAEEAKKADEakkaeEAKKADEAKKAEEKKKADEL 1551

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  665 RVEKE---SLEKNLSERKKKSAQERSQAE---EEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWE 738
Cdd:PTZ00121 1552 KKAEElkkAEEKKKAEEAKKAEEDKNMALrkaEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEE 1631

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  739 AKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIK---ELEKNKSQMSGVEAAASDP 815
Cdd:PTZ00121 1632 KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKaaeALKKEAEEAKKAEELKKKE 1711

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  816 SEKVKKImnqvfQSLRREFEleesyngrtilgtiMNTIKMVTLQllnqqeqekeeSSSEEEEEKAEERPRRPSQEQSASA 895
Cdd:PTZ00121 1712 AEEKKKA-----EELKKAEE--------------ENKIKAEEAK-----------KEAEEDKKKAEEAKKDEEEKKKIAH 1761

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 578817221  896 SSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQD 936
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKD 1802

PRK02224

DNA double-strand break repair Rad50 ATPase;

499-709

1.93e-04

DNA double-strand break repair Rad50 ATPase;

Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 45.80 E-value: 1.93e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  499 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQsnlMMEKRN--NSLQTATENTQARVLHAEQEKAKVTEE 576
Cdd:PRK02224  511 IERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAE---AEEKREaaAEAEEEAEEAREEVAELNSKLAELKER 587

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  577 L-------------AAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTkvQAKLSELQETSEQAqskfkse 643
Cdd:PRK02224  588 IeslerirtllaaiADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFD--EARIEEAREDKERA------- 658

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578817221  644 KQNRKQLELKVTSLEEELTDLRVE----KESLE--KNLSERKKKSAQERSQAE---EEIDEIRKSYQEELDKLRQ 709
Cdd:PRK02224  659 EEYLEQVEEKLDELREERDDLQAEigavENELEelEELRERREALENRVEALEalyDEAEELESMYGDLRAELRQ 733

COG4026

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...

589-714

1.98e-04

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];

Pssm-ID: 443204 [Multi-domain] Cd Length: 287 Bit Score: 44.72 E-value: 1.98e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  589 LKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSekqnrkqLELKVTSLEEELTDLRVEK 668
Cdd:COG4026   121 LKSLQNIPEYNELREELLELKEKIDEIAKEKEKLTKENEELESELEELREEYKK-------LREENSILEEEFDNIKSEY 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 578817221  669 ESLEKNLSERKKKSAQERSQAEEEIDEIrksYQEELDKLRQLLKKT 714
Cdd:COG4026   194 SDLKSRFEELLKKRLLEVFSLEELWKEL---FPEELPEEDFIYFAT 236

COG4372

Uncharacterized protein, contains DUF3084 domain [Function unknown];

616-829

2.27e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];

Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.89 E-value: 2.27e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  616 RGQLTKVQAKLSELQETSEQAQSKfksEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKksaqERSQAEEEIDE 695
Cdd:COG4372    12 RLSLFGLRPKTGILIAALSEQLRK---ALFELDKLQEELEQLREELEQAREELEQLEEELEQARS----ELEQLEEELEE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  696 IRKSYQEELDKLRQllkktrvstdqaAAEQLSLVQaelqtqweakcehllasakdehlQQYQEVCAQRDAYQQKLVQLQE 775
Cdd:COG4372    85 LNEQLQAAQAELAQ------------AQEELESLQ-----------------------EEAEELQEELEELQKERQDLEQ 129

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578817221  776 KCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQS 829
Cdd:COG4372   130 QRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQ 183

COG5022

Myosin heavy chain [General function prediction only];

511-849

2.44e-04

Myosin heavy chain [General function prediction only];

Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 45.45 E-value: 2.44e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  511 QEILEKSNRIEEQNDKISElIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVShlQLK 590
Cdd:COG5022   800 QPLLSLLGSRKEYRSYLAC-IIKLQKTIKREKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFSLLKKETIYLQS--AQR 876

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  591 MTAHQKKETELQMQLTE--SLKETDLlrgQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEK 668
Cdd:COG5022   877 VELAERQLQELKIDVKSisSLKLVNL---ELESEIIELKKSLSSDLIENLEFKTELIARLKKLLNNIDLEEGPSIEYVKL 953

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  669 ESLEKNLSERK--KKSAQERS----QAEEEIDEIRKSyQEELDKLRQLLKKTRV--STDQAAAEQLSLVQAELQTQWEAk 740
Cdd:COG5022   954 PELNKLHEVESklKETSEEYEdllkKSTILVREGNKA-NSELKNFKKELAELSKqyGALQESTKQLKELPVEVAELQSA- 1031

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  741 cEHLLASAKdEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITaLTKQNEQHIKELEKNKSQMSGVEAA--------A 812
Cdd:COG5022  1032 -SKIISSES-TELSILKPLQKLKGLLLLENNQLQARYKALKLRRE-NSLLDDKQLYQLESTENLLKTINVKdlevtnrnL 1108

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 578817221  813 SDPSEKVKKImnqVFQSLRREFELEESYNGRTILGTI 849
Cdd:COG5022  1109 VKPANVLQFI---VAQMIKLNLLQEISKFLSQLVNTL 1142

MukB

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...

495-691

2.64e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 45.33 E-value: 2.64e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKI---SELIERNQRYVEQSNLMMEKRNNSLqtaTENTQARVLHAEQEKA 571
Cdd:COG3096   925 LVAVLQSDPEQFEQLQADYLQAKEQQRRLKQQIfalSEVVQRRPHFSYEDAVGLLGENSDL---NEKLRARLEQAEEARR 1001

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  572 KVTEELAAATAQVSH----LQLKMTAHQKKETELQmQLTESLKETDllrgqltkVQAKlselQETSEQAQSKfKSEKQNR 647
Cdd:COG3096  1002 EAREQLRQAQAQYSQynqvLASLKSSRDAKQQTLQ-ELEQELEELG--------VQAD----AEAEERARIR-RDELHEE 1067

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 578817221  648 -KQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE 691
Cdd:COG3096  1068 lSQNRSRRSQLEKQLTRCEAEMDSLQKRLRKAERDYKQEREQVVQ 1112

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

567-826

2.78e-04

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 45.01 E-value: 2.78e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   567 EQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQN 646
Cdd:TIGR04523   39 EKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQ 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   647 RKQLELKVTSLEEELTDlrvEKESLEKNLSERKKKSaQERSQAEEEIDEIRK---SYQEELDKL-RQLLKKTRVSTD--- 719
Cdd:TIGR04523  119 KNKLEVELNKLEKQKKE---NKKNIDKFLTEIKKKE-KELEKLNNKYNDLKKqkeELENELNLLeKEKLNIQKNIDKikn 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   720 QAAAEQLSLVQAELQTQweakcEHLLASAKDEHL-QQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKEL 798
Cdd:TIGR04523  195 KLLKLELLLSNLKKKIQ-----KNKSLESQISELkKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQL 269

                          250       260
                   ....*....|....*....|....*...
gi 578817221   799 EKNKSQMSGVEAAASDPSEKVKKIMNQV 826
Cdd:TIGR04523  270 SEKQKELEQNNKKIKELEKQLNQLKSEI 297

CwlO1

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...

520-736

2.80e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];

Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 44.82 E-value: 2.80e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  520 IEEQNDKISELIERNQRYVEQSNLMMEKRNnSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQ--LKMTAHQKK 597
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELE-ELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERReeLGERARALY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  598 ETELQMQLTESLKE----TDLLRG-----QLTKVQAKL----SELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDL 664
Cdd:COG3883    97 RSGGSVSYLDVLLGsesfSDFLDRlsalsKIADADADLleelKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578817221  665 RVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQ 736
Cdd:COG3883   177 QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAG 248

COG1340

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

638-825

2.80e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 44.13 E-value: 2.80e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  638 SKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKsYQEELDKLRQLLKKTRVS 717
Cdd:COG1340     1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQE-LREKRDELNEKVKELKEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  718 TDQaAAEQLSLVQAELQtqwEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLV-------QLQEKCLALQAQITALTKQ 790
Cdd:COG1340    80 RDE-LNEKLNELREELD---ELRKELAELNKAGGSIDKLRKEIERLEWRQQTEVlspeeekELVEKIKELEKELEKAKKA 155

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 578817221  791 NEQHiKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 825
Cdd:COG1340   156 LEKN-EKLKELRAELKELRKEAEEIHKKIKELAEE 189

PRK00409

recombination and DNA strand exchange inhibitor protein; Reviewed

645-822

2.84e-04

recombination and DNA strand exchange inhibitor protein; Reviewed

Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 45.20 E-value: 2.84e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  645 QNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDK-LRQLLKKTRVSTDQAAA 723
Cdd:PRK00409  527 ELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQAIKEAKKEADEiIKELRQLQKGGYASVKA 606

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  724 EQLSLVQAELQTQWEAKCEHLLASAKDEH-LQQYQEVcaqrdayqqKLVQLQEKclalqAQITALTKQNE---Q------ 793
Cdd:PRK00409  607 HELIEARKRLNKANEKKEKKKKKQKEKQEeLKVGDEV---------KYLSLGQK-----GEVLSIPDDKEaivQagimkm 672

                         170       180       190
                  ....*....|....*....|....*....|.
gi 578817221  794 --HIKELEKNKSQmsgveaaasdPSEKVKKI 822
Cdd:PRK00409  673 kvPLSDLEKIQKP----------KKKKKKKP 693

COG2433

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];

607-715

3.04e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];

Pssm-ID: 441980 [Multi-domain] Cd Length: 644 Bit Score: 44.85 E-value: 3.04e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  607 ESLKEtdLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNR-KQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQE 685
Cdd:COG2433   376 LSIEE--ALEELIEKELPEEEPEAEREKEHEERELTEEEEEiRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEA 453

                          90       100       110
                  ....*....|....*....|....*....|..
gi 578817221  686 RSQAEEEIDEIRK--SYQEELDKLRQLLKKTR 715
Cdd:COG2433   454 RSEERREIRKDREisRLDREIERLERELEEER 485

Rabaptin

pfam03528

Rabaptin;

595-802

3.04e-04

Rabaptin;

Pssm-ID: 367545 [Multi-domain] Cd Length: 486 Bit Score: 44.71 E-value: 3.04e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   595 QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEqaqskfksEKQNRKQLELKVTslEEELTDLRVEKESLEKN 674
Cdd:pfam03528    7 QQRVAELEKENAEFYRLKQQLEAEFNQKRAKFKELYLAKE--------EDLKRQNAVLQEA--QVELDALQNQLALARAE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   675 LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWE------AKCEHLLASA 748
Cdd:pfam03528   77 MENIKAVATVSENTKQEAIDEVKSQWQEEVASLQAIMKETVREYEVQFHRRLEQERAQWNQYREsaereiADLRRRLSEG 156

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221   749 KDEHLQQYQEVCAQRDAYQQKLV--QLQEKCLALQAQITaltkQNEQHIKELEKNK 802
Cdd:pfam03528  157 QEEENLEDEMKKAQEDAEKLRSVvmPMEKEIAALKAKLT----EAEDKIKELEASK 208

MAD

pfam05557

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...

501-794

3.37e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.

Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 44.73 E-value: 3.37e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   501 RIIQ-ENERLKQEILEKSNRIEEQNdKISELIERNQRYVEqsnlmmekRNNSLQTATENTQARvLHAEQEKAKVTEELAA 579
Cdd:pfam05557   10 RLSQlQNEKKQMELEHKRARIELEK-KASALKRQLDRESD--------RNQELQKRIRLLEKR-EAEAEEALREQAELNR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   580 ATAQ----VSHLQLKMTAHQKKETELQMQLTESLKE--TDLLRGQLtKVQAKLSELQETSEQ---AQSKFKSEKQNRKQL 650
Cdd:pfam05557   80 LKKKyleaLNKKLNEKESQLADAREVISCLKNELSElrRQIQRAEL-ELQSTNSELEELQERldlLKAKASEAEQLRQNL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   651 ELKVTSL---EEELTDLRVEKESLEKNLSERKKKSAQ---------ERSQAEEEIDEIRKS------YQEELDKLRQLLK 712
Cdd:pfam05557  159 EKQQSSLaeaEQRIKELEFEIQSQEQDSEIVKNSKSElaripelekELERLREHNKHLNENienkllLKEEVEDLKRKLE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   713 KTRVSTDQAAAEQLSL--VQAELQtQWE----AKCEHL----LASAKDEHLQQYQEVCAQRD--------AYQQKLVQLQ 774
Cdd:pfam05557  239 REEKYREEAATLELEKekLEQELQ-SWVklaqDTGLNLrspeDLSRRIEQLQQREIVLKEENssltssarQLEKARRELE 317

                          330       340
                   ....*....|....*....|
gi 578817221   775 EKCLALQAQITALTKQNEQH 794
Cdd:pfam05557  318 QELAQYLKKIEDLNKKLKRH 337

Atrophin-1

pfam03154

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...

239-427

3.41e-04

Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.76 E-value: 3.41e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   239 SAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSnslseqlAINTSPDAVKAKLISRMAKMgQPMLPILPPQldsn 318
Cdd:pfam03154  192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHT-------LIQQTPTLHPQRLPSPHPPL-QPMTQPPPPS---- 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   319 dseiedvntlqgggQPVVTPSVQPSLHPAHPALPQMTSQAPqpsvTGLQAPSAAL-MQVSSLDSHSAVSGNAQSFQPYAG 397
Cdd:pfam03154  260 --------------QVSPQPLPQPSLHGQMPPMPHSLQTGP----SHMQHPVPPQpFPLTPQSSQSQVPPGPSPAAPGQS 321

                          170       180       190
                   ....*....|....*....|....*....|..
gi 578817221   398 MQAYAYPQASAVTSQLQPVR--PLYPAPLSQP 427
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQPPReqPLPPAPLSMP 353

Laminin_I

pfam06008

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...

572-790

3.50e-04

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.

Pssm-ID: 310534 [Multi-domain] Cd Length: 258 Bit Score: 43.56 E-value: 3.50e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   572 KVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKS--------- 642
Cdd:pfam06008   16 KINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERTLGHAKElaeaiknli 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   643 ----------EKQNRKQLELKVTSLEEELTDL-RVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLL 711
Cdd:pfam06008   96 dnikeinekvATLGENDFALPSSDLSRMLAEAqRMLGEIRSRDFGTQLQNAEAELKAAQDLLSRIQTWFQSPQEENKALA 175

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578817221   712 KKTRvstdqaaaEQLSLVQAELQTQWEAKCEHLLASAKDEHLQqyQEVCAQRDAYQQKLVQLQEkclaLQAQITALTKQ 790
Cdd:pfam06008  176 NALR--------DSLAEYEAKLSDLRELLREAAAKTRDANRLN--LANQANLREFQRKKEEVSE----QKNQLEETLKT 240

EzrA

pfam06160

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...

495-726

3.51e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.

Pssm-ID: 428797 [Multi-domain] Cd Length: 542 Bit Score: 44.46 E-value: 3.51e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   495 IMSNIQRI---IQEN----ERLKQEILEKSNR-IEEQNDKISELIER----------NQRYVEQSNLMMEKRNNSLQTAT 556
Cdd:pfam06160  235 VDKEIQQLeeqLEENlallENLELDEAEEALEeIEERIDQLYDLLEKevdakkyvekNLPEIEDYLEHAEEQNKELKEEL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   557 ENTQARVLHAEQEKAKV---TEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKetdllrgQLTKVQAKLSELQets 633
Cdd:pfam06160  315 ERVQQSYTLNENELERVrglEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILE-------QLEEIEEEQEEFK--- 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   634 EQAQSKFKSEKQNRKQLELKVTSLEEelTDLRVEKE---SLEKNLSERKKKSAQERSQAEEE-------IDEIRKSYQEE 703
Cdd:pfam06160  385 ESLQSLRKDELEAREKLDEFKLELRE--IKRLVEKSnlpGLPESYLDYFFDVSDEIEDLADElnevplnMDEVNRLLDEA 462

                          250       260
                   ....*....|....*....|....
gi 578817221   704 LDKLRQLLKKTRVSTDQAA-AEQL 726
Cdd:pfam06160  463 QDDVDTLYEKTEELIDNATlAEQL 486

PRK03918

DNA double-strand break repair ATPase Rad50;

495-704

3.96e-04

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 44.67 E-value: 3.96e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRIIQENERLKQEILEKS-NRIEEQNDKISELIERNQRYVEQSNlmMEKRNNSLQTATENTQARVLHAEQEKAKV 573
Cdd:PRK03918  561 LEKKLDELEEELAELLKELEELGfESVEELEERLKELEPFYNEYLELKD--AEKELEREEKELKKLEEELDKAFEELAET 638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  574 TEELAAATAQVSHLQLKMTahQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEqaqsKFKSEKQNRKQLELK 653
Cdd:PRK03918  639 EKRLEELRKELEELEKKYS--EEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLE----KLKEELEEREKAKKE 712

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578817221  654 VTSLEEELTDLRVEKESLeknlserKKKSAQERSQAEEEIDEIRKSYQEEL 704
Cdd:PRK03918  713 LEKLEKALERVEELREKV-------KKYKALLKERALSKVGEIASEIFEEL 756

rad50

TIGR00606

rad50; All proteins in this family for which functions are known are involvedin recombination, ...

503-803

4.13e-04

Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 44.65 E-value: 4.13e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   503 IQENE-RLKQEILEKSNRIEEQNDKISELIERNQryvEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAAT 581
Cdd:TIGR00606  370 IQSLAtRLELDGFERGPFSERQIKNFHTLVIERQ---EDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKK 446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   582 AQVSHLQLKMtahQKKETELQmQLTESLKETDLLRGQLTKVQAKLSELQETS--EQAQSKFKSEKQNRKQLELKVTSLEE 659
Cdd:TIGR00606  447 EILEKKQEEL---KFVIKELQ-QLEGSSDRILELDQELRKAERELSKAEKNSltETLKKEVKSLQNEKADLDRKLRKLDQ 522

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   660 ELTDLRVEKESLEKNLSERKKKsaqerSQAEEEIDEIRKSYQEEL--------------DKLRQLLKKTRVSTDQAAAEQ 725
Cdd:TIGR00606  523 EMEQLNHHTTTRTQMEMLTKDK-----MDKDEQIRKIKSRHSDELtsllgyfpnkkqleDWLHSKSKEINQTRDRLAKLN 597

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   726 LSLVQAE-LQTQWEAKCEhllasAKDEHLQQYQ----EVCAQRDaYQQKLVQLQ---EKCLALQAQITALTKQNEQHIKE 797
Cdd:TIGR00606  598 KELASLEqNKNHINNELE-----SKEEQLSSYEdklfDVCGSQD-EESDLERLKeeiEKSSKQRAMLAGATAVYSQFITQ 671


                   ....*.
gi 578817221   798 LEKNKS 803
Cdd:TIGR00606  672 LTDENQ 677

PRK04778

septation ring formation regulator EzrA; Provisional

602-835

4.21e-04

septation ring formation regulator EzrA; Provisional

Pssm-ID: 179877 [Multi-domain] Cd Length: 569 Bit Score: 44.44 E-value: 4.21e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  602 QMQLT-ESLKETDLLRGQLTKVQA-KLSELQETSEQA-----QSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKn 674
Cdd:PRK04778   55 KLNLTgQSEEKFEEWRQKWDEIVTnSLPDIEEQLFEAeelndKFRFRKAKHEINEIESLLDLIEEDIEQILEELQELLE- 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  675 lSErkKKSAQERSQAEEEIDEIRK-------SYQEELDKLRQLLKKTRVSTDQ-----------AAAEQLSLVQAELqTQ 736
Cdd:PRK04778  134 -SE--EKNREEVEQLKDLYRELRKsllanrfSFGPALDELEKQLENLEEEFSQfveltesgdyvEAREILDQLEEEL-AA 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  737 WEAKCEH---LLASAKDEHLQQYQEVcaqRDAYQQKLVQ---LQEkcLALQAQITALTKQ---NEQHIKELEknksqmsg 807
Cdd:PRK04778  210 LEQIMEEipeLLKELQTELPDQLQEL---KAGYRELVEEgyhLDH--LDIEKEIQDLKEQideNLALLEELD-------- 276

                         250       260       270
                  ....*....|....*....|....*....|.
gi 578817221  808 VEAAasdpSEKVKKI---MNQVFQSLRREFE 835
Cdd:PRK04778  277 LDEA----EEKNEEIqerIDQLYDILEREVK 303

ClpA

COG0542

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...

595-716

5.18e-04

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440308 [Multi-domain] Cd Length: 836 Bit Score: 44.30 E-value: 5.18e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  595 QKKETELQMQLTESLKETDLLRGQ-LTKVQAKLSELQETSEQAQSKFKSEKQnrkqLELKVTSLEEELTDLRVEKESLEK 673
Cdd:COG0542   417 ERRLEQLEIEKEALKKEQDEASFErLAELRDELAELEEELEALKARWEAEKE----LIEEIQELKEELEQRYGKIPELEK 492

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  674 NLSERKKKSAQERSQAEEEIDE--------------IRKSYQEELDKLRQL---LKKtRV 716
Cdd:COG0542   493 ELAELEEELAELAPLLREEVTEediaevvsrwtgipVGKLLEGEREKLLNLeeeLHE-RV 551

PHA03247

large tegument protein UL36; Provisional

900-1136

6.12e-04

large tegument protein UL36; Provisional

Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.16 E-value: 6.12e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  900 PQAPLNRERPESPMVPSEQVVEeavPLPPQALTTSQDghrrkgdseAEALSEIKDGSLPPELscipshrvlgPPTSIPPE 979
Cdd:PHA03247 2506 PDAPPAPSRLAPAILPDEPVGE---PVHPRMLTWIRG---------LEELASDDAGDPPPPL----------PPAAPPAA 2563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  980 PlgpvsmdsecEESLAASPMAAKPDNPSgkVCVREVAPDGPLQESSTRLSLT---SDPEEGDPLALGPESPGEPQPPQLK 1056
Cdd:PHA03247 2564 P----------DRSVPPPRPAPRPSEPA--VTSRARRPDAPPQSARPRAPVDdrgDPRGPAPPSPLPPDTHAPDPPPPSP 2631

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221 1057 KDDVTSSTGPHKELSSTEAGSTVAGAALRPSHHSQRSSLS-GDEEDELFKGATLKALRPKAQPeeededeVSMKGRPPPT 1135
Cdd:PHA03247 2632 SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPRRRAARPTVGS-------LTSLADPPPP 2704


                  .
gi 578817221 1136 P 1136
Cdd:PHA03247 2705 P 2705

PHA02562

endonuclease subunit; Provisional

434-678

6.39e-04

endonuclease subunit; Provisional

Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 43.85 E-value: 6.39e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  434 GDMASFLMTEARQHNTEIRMavskVADKMDHLMTKV-------EELQKHSAGNsmlipsmsVTMETSMIMSN---IQRII 503
Cdd:PHA02562  166 SEMDKLNKDKIRELNQQIQT----LDMKIDHIQQQIktynkniEEQRKKNGEN--------IARKQNKYDELveeAKTIK 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  504 QENERLKQEILEKSNRIEEQNDKISELierNQRYVEQSNLM--------MEKRNNSLQTATENtqarvLHAEQEK-AKVT 574
Cdd:PHA02562  234 AEIEELTDELLNLVMDIEDPSAALNKL---NTAAAKIKSKIeqfqkvikMYEKGGVCPTCTQQ-----ISEGPDRiTKIK 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  575 EELAAATAQVSHLQLKMTAHQKKE---TELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQnrkqle 651
Cdd:PHA02562  306 DKLKELQHSLEKLDTAIDELEEIMdefNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAE------ 379

                         250       260
                  ....*....|....*....|....*..
gi 578817221  652 lKVTSLEEELTDLRVEKESLEKNLSER 678
Cdd:PHA02562  380 -ELAKLQDELDKIVKTKSELVKEKYHR 405

PHA02562

endonuclease subunit; Provisional

497-718

6.50e-04

endonuclease subunit; Provisional

Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 43.85 E-value: 6.50e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  497 SNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQsnLMMEKRNNSLQTATENTQARVLHAEQEK-----A 571
Cdd:PHA02562  181 QQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDE--LVEEAKTIKAEIEELTDELLNLVMDIEDpsaalN 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  572 KVTEELAAATAQVSHLQLKMTAHQK----------------KETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQ 635
Cdd:PHA02562  259 KLNTAAAKIKSKIEQFQKVIKMYEKggvcptctqqisegpdRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKK 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  636 A---QSKFKSEKQNRKQLELKVTSLE---EELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDeirksyqeELDKLRQ 709
Cdd:PHA02562  339 LlelKNKISTNKQSLITLVDKAKKVKaaiEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKY--------HRGIVTD 410


                  ....*....
gi 578817221  710 LLKKTRVST 718
Cdd:PHA02562  411 LLKDSGIKA 419

PTZ00449

104 kDa microneme/rhoptry antigen; Provisional

884-1053

6.56e-04

104 kDa microneme/rhoptry antigen; Provisional

Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 43.91 E-value: 6.56e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  884 PRRPSQeqsasassgqPQAPLNRERPESPMVP--SEQVVEEAVPLPPQALTTSQDGHRRKGDSEAE-----ALSEIKDGS 956
Cdd:PTZ00449  633 PKRPPP----------PQRPSSPERPEGPKIIksPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKEtkttvVLDESFESI 702

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  957 LPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNP--SGKVCVREVAPDGPLQESSTRL----SL 1030
Cdd:PTZ00449  703 LKETLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIEFFTPpeEERTFFHETPADTPLPDILAEEfkeeDI 782

                         170       180
                  ....*....|....*....|....*
gi 578817221 1031 TSDPEEGDPLALGPESPGE--PQPP 1053
Cdd:PTZ00449  783 HAETGEPDEAMKRPDSPSEheDKPP 807

NST1

pfam13945

Salt tolerance down-regulator; NST1 is a family of proteins that seem to be involved, directly ...

534-704

7.44e-04

Salt tolerance down-regulator; NST1 is a family of proteins that seem to be involved, directly or indirectly, in the salt sensitivity of some cellular functions in yeast. It does this without affecting sodium accumulation. It negatively affects salt-tolerance through an interaction with the splicing factor Msl1p. This interaction stresses the importance of efficient RNA processing under salt stress conditions.

Pssm-ID: 372833 Cd Length: 186 Bit Score: 41.80 E-value: 7.44e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   534 NQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQkkeTELQMQLTESLKETD 613
Cdd:pfam13945    6 NNNSQNQQQNQHDNNTVDHHSQVNSSKRKSKKKKKKKNRNGSNNNNDESSTSQSTPSPFAIT---TSSTRPVSNNPPLSS 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   614 LLRGQLTKVQAKLSELQETSEQaqskfkSEKQNRKQLELKVTslEEELTDL-RVEKESLEKNLSERKKKS------AQER 686
Cdd:pfam13945   83 SAASRSAHKNNKDRSIWNTSTQ------EERENIKEFWLSLG--EEERRSLvKVEKEAVLKKMKEQQKHScsctvcGRKR 154

                          170
                   ....*....|....*...
gi 578817221   687 SQAEEEIDEIRKSYQEEL 704
Cdd:pfam13945  155 TAIEEELEVLYDAYYEEL 172

PTZ00440

reticulocyte binding protein 2-like protein; Provisional

504-735

8.07e-04

reticulocyte binding protein 2-like protein; Provisional

Pssm-ID: 240419 [Multi-domain] Cd Length: 2722 Bit Score: 44.05 E-value: 8.07e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  504 QENERLKQEILEKSNRIEEQNDKISELIERN----QRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAA 579
Cdd:PTZ00440  560 KLKRSMKNDIKNKIKYIEENVDHIKDIISLNdeidNIIQQIEELINEALFNKEKFINEKNDLQEKVKYILNKFYKGDLQE 639

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  580 ATAQVSHLQLKMTA--HQKKETE-LQMQLTESLKETDLLR-----------GQLTKVQAKLSELQET--SEQAQSKFKSE 643
Cdd:PTZ00440  640 LLDELSHFLDDHKYlyHEAKSKEdLQTLLNTSKNEYEKLEfmksdnidniiKNLKKELQNLLSLKENiiKKQLNNIEQDI 719

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  644 KQNRKQLELKVTSLEEELTDLRVEKESLE---KNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQ 720
Cdd:PTZ00440  720 SNSLNQYTIKYNDLKSSIEEYKEEEEKLEvykHQIINRKNEFILHLYENDKDLPDGKNTYEEFLQYKDTILNKENKISND 799

                         250
                  ....*....|....*..
gi 578817221  721 AAA--EQLSLVQAELQT 735
Cdd:PTZ00440  800 INIlkENKKNNQDLLNS 816

PHA03307

transcriptional regulator ICP4; Provisional

956-1136

8.61e-04

transcriptional regulator ICP4; Provisional

Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 8.61e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  956 SLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPDGPLQESSTRLSLTSDPE 1035
Cdd:PHA03307   92 LSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQ 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221 1036 EGDPLALGPES---PGEPQPPQLKKDDVTSSTGPHKELSSTEAGSTVAGAALRPShhSQRSSLSGDEEDELfkgatlkal 1112
Cdd:PHA03307  172 AALPLSSPEETaraPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGR--SAADDAGASSSDSS--------- 240

                         170       180
                  ....*....|....*....|....
gi 578817221 1113 rpKAQPEEEDEDEVSMKGRPPPTP 1136
Cdd:PHA03307  241 --SSESSGCGWGPENECPLPRPAP 262

PRK10246

exonuclease subunit SbcC; Provisional

434-797

9.21e-04

exonuclease subunit SbcC; Provisional

Pssm-ID: 182330 [Multi-domain] Cd Length: 1047 Bit Score: 43.64 E-value: 9.21e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  434 GDMASFLMTEARQH--------NTEIRMAVS-KVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMimsniQRIIQ 504
Cdd:PRK10246  156 GQFAAFLNAKPKERaelleeltGTEIYGQISaMVFEQHKSARTELEKLQAQASGVALLTPEQVQSLTASL-----QVLTD 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  505 ENERL--KQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLH------AEQEKA----- 571
Cdd:PRK10246  231 EEKQLltAQQQQQQSLNWLTRLDELQQEASRRQQALQQALAAEEKAQPQLAALSLAQPARQLRphweriQEQSAAlahtr 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  572 ----KVTEELAAATAQVSHL-QLKMTAHQKKETELQmQLTESLKETDLLR-------------GQLTKVQAKLSELQETS 633
Cdd:PRK10246  311 qqieEVNTRLQSTMALRARIrHHAAKQSAELQAQQQ-SLNTWLAEHDRFRqwnnelagwraqfSQQTSDREQLRQWQQQL 389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  634 EQAQSKFKS-----------------EKQNRKQ-LELKVTSLEEELTDLRVEKESLEKNLSerkkKSAQERSQAEEEIDE 695
Cdd:PRK10246  390 THAEQKLNAlpaitltltadevaaalAQHAEQRpLRQRLVALHGQIVPQQKRLAQLQVAIQ----NVTQEQTQRNAALNE 465

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  696 IRKSYQEeldKLRQLLKKTRVSTDQAAAEQLSLVQAELQTqweAKCEHLLASAKDEHLQQYQEVC-----AQRDAYQQKL 770
Cdd:PRK10246  466 MRQRYKE---KTQQLADVKTICEQEARIKDLEAQRAQLQA---GQPCPLCGSTSHPAVEAYQALEpgvnqSRLDALEKEV 539

                         410       420
                  ....*....|....*....|....*..
gi 578817221  771 VQLQEKCLALQAQITALTKQNEQHIKE 797
Cdd:PRK10246  540 KKLGEEGAALRGQLDALTKQLQRDESE 566

AmmeMemoSam_B

TIGR04336

AmmeMemoRadiSam system protein B; Members of this protein family belong to the same domain ...

946-1004

9.34e-04

Pssm-ID: 275135 [Multi-domain] Cd Length: 269 Bit Score: 42.56 E-value: 9.34e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221   946 AEALSEIKDGslPPELSCI--PSHRVLGPPTSIPPE-----PLGPVSMDSECEESLAASPMAAKPD 1004
Cdd:TIGR04336   55 AHAYAALKKG--RPETVVLlgPNHTGYGSGIALPPEgswetPLGDVPVDEELAEELLEHSPIIELD 118

EzrA

COG4477

Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome ...

443-806

9.42e-04

Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443574 [Multi-domain] Cd Length: 567 Bit Score: 43.29 E-value: 9.42e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  443 EARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMlipsmsvtmetsmimsNIQRIIQENERLKQEILEKSN---- 518
Cdd:COG4477   101 KAKKALDEIEQLLDEIEEEIEEILEELEELLESEEKNRE----------------EIEELKEKYRELRKTLLAHRHsfgp 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  519 ---RIEEQNDKISELIERNQRYVEQSNlMMEKRN--NSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTA 593
Cdd:COG4477   165 aaeELEKQLEELEPEFEEFEELTESGD-YLEAREilEQLEEELNALEELMEEIPPLLKELQTELPDQLEELKSGYREMKE 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  594 ------HQKKETELQmQLTESLKET--DLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLR 665
Cdd:COG4477   244 qgyvleHLNIEKEIE-QLEEQLKEAleLLEELDLDEAEEELEEIEEEIDELYDLLEKEVEAKKYVDKNQEELEEYLEHLK 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  666 VEKESLEknlserkkksaqersqaeEEIDEIRKSYQ---EELDKLRQLLKktrvstdqaaaeQLSLVQAELQTqweakce 742
Cdd:COG4477   323 EQNRELK------------------EEIDRVQQSYRlneNELEKVRNLEK------------QIEELEKRYDE------- 365

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578817221  743 hlLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKqNEQHIKE-LEKNKSQMS 806
Cdd:COG4477   366 --IDERIEEEKVAYSELQEELEEIEEQLEEIEEEQEEFSEKLKSLRK-DELEAREkLDELKKKLR 427

sbcc

TIGR00618

exonuclease SbcC; All proteins in this family for which functions are known are part of an ...

441-713

9.61e-04

Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 43.42 E-value: 9.61e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   441 MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNS----MLIPSMSVTMETSMIMSNIQRIIQENERLKQEI-LE 515
Cdd:TIGR00618  565 MQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSeaedMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELaLK 644

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   516 KSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV-------------LHAEQEKAK-----VTEEL 577
Cdd:TIGR00618  645 LTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLtywkemlaqcqtlLRELETHIEeydreFNEIE 724

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   578 AAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLrgQLTKVQAKLSELQETSEQAQSKFKSEKQNRkQLELKVTSL 657
Cdd:TIGR00618  725 NASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEA--HFNNNEEVTAALQTGAELSHLAAEIQFFNR-LREEDTHLL 801

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221   658 EEELTDLRVEKESLEKNLSERKKKSAQERSQAEE----------EIDEIRKSYQEELDKLRQLLKK 713
Cdd:TIGR00618  802 KTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSrleeksatlgEITHQLLKYEECSKQLAQLTQE 867

PTZ00440

reticulocyte binding protein 2-like protein; Provisional

460-703

9.88e-04

reticulocyte binding protein 2-like protein; Provisional

Pssm-ID: 240419 [Multi-domain] Cd Length: 2722 Bit Score: 43.67 E-value: 9.88e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  460 DKMDHLMTKVEELQKHSagNSMLIPSMSVTMETSMIMSNIQRIIQENERL------KQEILEKSNRIEEQNDKISELIER 533
Cdd:PTZ00440 2342 QDENYGKDKNIELNNEN--NSYIIKTKEKINNLKEEFSKLLKNIKRNNTLcnnnniKDFISNIGKSVETIKQRFSSNLPE 2419

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  534 NQRYV-------EQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLqlkmTAHQKKETELQMQLT 606
Cdd:PTZ00440 2420 KEKLHqieenlnEIKNIMNETKRISNVDAFTNKILQDIDNEKNKENNNMNAEKIDDLIENV----TSHNEKIKSELLIIN 2495

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  607 ESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQN-RKQLELKVTSLEE-------ELTDL-------------- 664
Cdd:PTZ00440 2496 DALRRVKEKKDEMNKLFNSLTENNNNNNNSAKNIVDNSTYiINELESHVSKLNEllsyidnEIKELeneklkllekakie 2575

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 578817221  665 --RVEKESLEKNLSERKKKSAQERSQAEEEI--DEIRKSYQEE 703
Cdd:PTZ00440 2576 esRKERERIESETQEDNTDEEQINRQQQERLqkEEEQKAYSQE 2618

PRK09039

peptidoglycan -binding protein;

509-647

1.21e-03

peptidoglycan -binding protein;

Pssm-ID: 181619 [Multi-domain] Cd Length: 343 Bit Score: 42.65 E-value: 1.21e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  509 LKQEILEKSNRIEEQNDKISELIERnqryveqsnLMMEKRNN-SLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHL 587
Cdd:PRK09039   44 LSREISGKDSALDRLNSQIAELADL---------LSLERQGNqDLQDSVANLRASLSAAEAERSRLQALLAELAGAGAAA 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  588 QLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKsEKQNR 647
Cdd:PRK09039  115 EGRAGELAQELDSEKQVSARALAQVELLNQQIAALRRQLAALEAALDASEKRDR-ESQAK 173

TPH

pfam13868

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...

499-772

1.32e-03

Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 42.21 E-value: 1.32e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   499 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERN--QRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKvtEE 576
Cdd:pfam13868   78 LEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEdqAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREE--DE 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   577 LAAATAQVSHLQLKMTAHQKKETELQMQlteslKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTS 656
Cdd:pfam13868  156 RILEYLKEKAEREEEREAEREEIEEEKE-----REIARLRAQQEKAQDEKAERDELRAKLYQEEQERKERQKEREEAEKK 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   657 LEEELtDLRvekESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQ 736
Cdd:pfam13868  231 ARQRQ-ELQ---QAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQIEEREEQR 306

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 578817221   737 WEAKcehllasakdEHLQQYQEVCAQRDAYQQKLVQ 772
Cdd:pfam13868  307 AAER----------EEELEEGERLREEEAERRERIE 332

ClyA_Cry6Aa-like

cd22656

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...

587-739

1.36e-03

Pssm-ID: 439154 [Multi-domain] Cd Length: 309 Bit Score: 42.36 E-value: 1.36e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  587 LQLKMTAHQKKETELQMQLTESLKE-TDLLRGQLTKVQAKLSELQEtseqAQSKFKSE-KQNRKQLELKVTSLEEELTD- 663
Cdd:cd22656    97 LELIDDLADATDDEELEEAKKTIKAlLDDLLKEAKKYQDKAAKVVD----KLTDFENQtEKDQTALETLEKALKDLLTDe 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  664 -LRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRqllKKTRVSTD-QAAAEQLSLVQA---------- 731
Cdd:cd22656   173 gGAIARKEIKDLQKELEKLNEEYAAKLKAKIDELKALIADDEAKLA---AALRLIADlTAADTDLDNLLAligpaipale 249


                  ....*...
gi 578817221  732 ELQTQWEA 739
Cdd:cd22656   250 KLQGAWQA 257

PRK04778

septation ring formation regulator EzrA; Provisional

495-726

1.37e-03

septation ring formation regulator EzrA; Provisional

Pssm-ID: 179877 [Multi-domain] Cd Length: 569 Bit Score: 42.90 E-value: 1.37e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRIIQENERLKQEI-------LEKSNR-IEEQNDKISELIERN---QRYVEQSN-------LMMEKRNNSLQTAT 556
Cdd:PRK04778  254 IEKEIQDLKEQIDENLALLeeldldeAEEKNEeIQERIDQLYDILEREvkaRKYVEKNSdtlpdflEHAKEQNKELKEEI 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  557 ENTQA--RVLHAEQEKAK-VTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKetdllrgQLTKVQAKLSELQETs 633
Cdd:PRK04778  334 DRVKQsyTLNESELESVRqLEKQLESLEKQYDEITERIAEQEIAYSELQEELEEILK-------QLEEIEKEQEKLSEM- 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  634 eqAQSKFKSEKQNRKQLELKVTSLEEelTDLRVEKE---SLEKNLSERKKKSAQERSQAEEEIDEIR---KSYQEELDK- 706
Cdd:PRK04778  406 --LQGLRKDELEAREKLERYRNKLHE--IKRYLEKSnlpGLPEDYLEMFFEVSDEIEALAEELEEKPinmEAVNRLLEEa 481

                         250       260
                  ....*....|....*....|....
gi 578817221  707 ---LRQLLKKTRVSTDQAA-AEQL 726
Cdd:PRK04778  482 tedVETLEEETEELVENATlTEQL 505

growth_prot_Scy

NF041483

polarized growth protein Scy;

552-835

1.42e-03

polarized growth protein Scy;

Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 42.89 E-value: 1.42e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  552 LQTATENTQARVLHAEQEKAKVTEELAAATAQVShlQLKMTAHQKKeTELQMQLTESLKETDLLRGQLTKVQAK-LSELQ 630
Cdd:NF041483  224 LNAASTQAQEATDHAEQLRSSTAAESDQARRQAA--ELSRAAEQRM-QEAEEALREARAEAEKVVAEAKEAAAKqLASAE 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  631 ETSEQAQSKFKSE-----KQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAeeEIDEIRKSYQEELD 705
Cdd:NF041483  301 SANEQRTRTAKEEiarlvGEATKEAEALKAEAEQALADARAEAEKLVAEAAEKARTVAAEDTAA--QLAKAARTAEEVLT 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  706 KLRQLLKktrvSTDQAAAEQLSLVQAELqtqwEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQIT 785
Cdd:NF041483  379 KASEDAK----ATTRAAAEEAERIRREA----EAEADRLRGEAADQAEQLKGAAKDDTKEYRAKTVELQEEARRLRGEAE 450

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817221  786 AL---------------TKQNEQHIKE--------LEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFE 835
Cdd:NF041483  451 QLraeavaegerirgeaRREAVQQIEEaartaeelLTKAKADADELRSTATAESERVRTEAIERATTLRRQAE 523

Nuf2_DHR10-like

pfam18595

Nuf2, DHR10-like domain; This domain is found at the C-terminal region of Nuf2 proteins. This ...

574-709

1.42e-03

Nuf2, DHR10-like domain; This domain is found at the C-terminal region of Nuf2 proteins. This domain was identified as MazG related domain also designated as Designed helical repeat protein 10 (DHR10) that actually adopts a coiled-coil structure. Nuf2 is part of the Ndc80 complex, which binds to the spindle and is required for chromosome segregation and spindle checkpoint activity.

Pssm-ID: 465814 [Multi-domain] Cd Length: 117 Bit Score: 39.49 E-value: 1.42e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   574 TEELAAATAQVSHLQLKMTAHQKKetelqmqlTESLK--ETDLlrgqltkvqAKLSELQETSEQAQSKFKSEKQNRKQLE 651
Cdd:pfam18595    1 SSTLAEEKEELAELERKARELQAK--------IDALQvvEKDL---------RSCIKLLEEIEAELAKLEEAKKKLKELR 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578817221   652 LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIrksyQEELDKLRQ 709
Cdd:pfam18595   64 DALEEKEIELRELERREERLQRQLENAQEKLERLREQAEEKREAA----QARLEELRE 117

CALCOCO1

pfam07888

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...

597-837

1.52e-03

Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 42.57 E-value: 1.52e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   597 KETELQMQLTESLKEtdllRGQLTKVQAKLSELQETSEQAQSKFKSE-KQNRKQLELKVTSLEEELTDLRVEKESLEknl 675
Cdd:pfam07888   28 RAELLQNRLEECLQE----RAELLQAQEAANRQREKEKERYKRDREQwERQRRELESRVAELKEELRQSREKHEELE--- 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   676 sERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTrvstdQAAAEQLSLVQAELQTQWEaKCEHLLASAKDEHlqq 755
Cdd:pfam07888  101 -EKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDI-----KTLTQRVLERETELERMKE-RAKKAGAQRKEEE--- 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   756 yqevcAQRDAYQQKLVQLQEKCLALQaqitaltkqneqhiKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFE 835
Cdd:pfam07888  171 -----AERKQLQAKLQQTEEELRSLS--------------KEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAE 231


                   ..
gi 578817221   836 LE 837
Cdd:pfam07888  232 NE 233

YkyA

pfam10368

Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein ...

621-800

1.68e-03

Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein signal and a hydrolase domain. It is similar to cell wall binding proteins and might also be recognisable by a host immune defence system. It is thus likely to belong to pathways important for pathogenicity.

Pssm-ID: 431235 [Multi-domain] Cd Length: 185 Bit Score: 40.65 E-value: 1.68e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   621 KVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQA-EEEIDEIRKS 699
Cdd:pfam10368    1 SPEEKIYDHLEEAVELEKPFEEQQEPLVELEKKEQELYEEIIELGMDEFDEIKKLSDEALENVEEREELlEKEKESIEEA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   700 YqEELDKLRQLLKKTRvstDQAAAEQLSLVQAELQTQWEAkceHllasakDEHLQQYQE-VCAQRDAY---QQKLVQLQE 775
Cdd:pfam10368   81 K-EEFKKIKEIIEEIE---DEELKKEAEELIDAMEERYEA---Y------DELYDAYKKaLELDKELYemlKDEDLTLEE 147

                          170       180
                   ....*....|....*....|....*
gi 578817221   776 kclaLQAQITALTKQNEQHIKELEK 800
Cdd:pfam10368  148 ----LQEQIEKINESYEEVKEANEQ 168

PspC_subgroup_1

NF033838

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...

495-713

1.69e-03

Pssm-ID: 468201 [Multi-domain] Cd Length: 684 Bit Score: 42.69 E-value: 1.69e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRIIQEnerlKQEILEKSNRIeeQN-DKISELIERNQRYVEQSNLMMEKRNNSLQTAT-ENTQARVLHAEQEKAK 572
Cdd:NF033838   63 VESHLEKILSE----IQKSLDKRKHT--QNvALNKKLSDIKTEYLYELNVLKEKSEAELTSKTkKELDAAFEQFKKDTLE 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  573 VTEELAAATAQVSHLQLKmtAHQKKETELQMQLTESLKETDLLRGQlTKVQAKLSELQETSEQAQSKFKSEKQnrKQLEL 652
Cdd:NF033838  137 PGKKVAEATKKVEEAEKK--AKDQKEEDRRNYPTNTYKTLELEIAE-SDVEVKKAELELVKEEAKEPRDEEKI--KQAKA 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817221  653 KVTSLEEELTdlrvekeSLEKNLSERKK--KSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK 713
Cdd:NF033838  212 KVESKKAEAT-------RLEKIKTDREKaeEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKR 267

PRK10263

DNA translocase FtsK; Provisional

329-423

1.83e-03

DNA translocase FtsK; Provisional

Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.76 E-value: 1.83e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  329 QGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQA------PSAALMQVSSLDSHSAVSGN-AQSFQPYAGMQAY 401
Cdd:PRK10263  738 DGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQyqqpqqPVAPQPQYQQPQQPVAPQPQyQQPQQPVAPQPQY 817

                          90       100
                  ....*....|....*....|....
gi 578817221  402 AYPQASAVTSQ--LQPVRPLYPAP 423
Cdd:PRK10263  818 QQPQQPVAPQPqyQQPQQPVAPQP 841

WH1

smart00461

WASP homology region 1; Region of the Wiskott-Aldrich syndrome protein (WASp) that contains ...

2-100

1.86e-03

Pssm-ID: 214674 Cd Length: 106 Bit Score: 38.88 E-value: 1.86e-03

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221      2 STPTILVATAVHAYRYTNGQYVKQGKFGAAVLG---NHTAREYRILLYISQQQPVTVARIHVNFELMVRPNNYSTFYDDQ 78
Cdd:smart00461    3 SQCIILARAVVQLYDADTKKWVPTGEGGAANLVidkNQRSYFFRIVGIKGQDKVIWNQELYKNFKYNQATPTFHQWADDK 82

                            90       100
                    ....*....|....*....|..
gi 578817221     79 RQnWSIMFESEKAAVEFNKQVC 100
Cdd:smart00461   83 CV-YGLNFASEEEAKKFRKKVL 103

PRK04778

septation ring formation regulator EzrA; Provisional

495-800

1.93e-03

septation ring formation regulator EzrA; Provisional

Pssm-ID: 179877 [Multi-domain] Cd Length: 569 Bit Score: 42.13 E-value: 1.93e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  495 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIER-NQRYVEQSNLMMEKRnNSLQTATENTQARVLHAEQEKAKV 573
Cdd:PRK04778  106 EINEIESLLDLIEEDIEQILEELQELLESEEKNREEVEQlKDLYRELRKSLLANR-FSFGPALDELEKQLENLEEEFSQF 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  574 TEElaaaTAQVSHLQLKMTAHQKKETELQM-QLTESLKEtdLLRGQLTKVQAKLSELQETSEQAqskfksEKQNRKqleL 652
Cdd:PRK04778  185 VEL----TESGDYVEAREILDQLEEELAALeQIMEEIPE--LLKELQTELPDQLQELKAGYREL------VEEGYH---L 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  653 KVTSLEEELTDLRVEKESLEKNLSERKKKSAQER-SQAEEEIDEI----------RKSYQEELDKLRQLLKKTRVSTDQA 721
Cdd:PRK04778  250 DHLDIEKEIQDLKEQIDENLALLEELDLDEAEEKnEEIQERIDQLydilerevkaRKYVEKNSDTLPDFLEHAKEQNKEL 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  722 AAEQLSLVQA------ELQTQWEAKCEhlLASAKDEHLQQYQEVCAQRDAYQqklvQLQEKCLALQAQITALTKQNEQ-- 793
Cdd:PRK04778  330 KEEIDRVKQSytlnesELESVRQLEKQ--LESLEKQYDEITERIAEQEIAYS----ELQEELEEILKQLEEIEKEQEKls 403


                  ....*...
gi 578817221  794 -HIKELEK 800
Cdd:PRK04778  404 eMLQGLRK 411

PRK12704

phosphodiesterase; Provisional

560-736

2.05e-03

phosphodiesterase; Provisional

Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 42.07 E-value: 2.05e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  560 QARVLHAEQEKAKVTEElAAATAQVshlqlkmtahQKKETELQMQlteslKETDLLRGQLTK-VQAKLSELQETSEQAQS 638
Cdd:PRK12704   30 EAKIKEAEEEAKRILEE-AKKEAEA----------IKKEALLEAK-----EEIHKLRNEFEKeLRERRNELQKLEKRLLQ 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  639 KFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKnlserkkksaqersqAEEEIDEIRKSYQEELDKLRQLlkktrvST 718
Cdd:PRK12704   94 KEENLDRKLELLEKREEELEKKEKELEQKQQELEK---------------KEEELEELIEEQLQELERISGL------TA 152

                         170
                  ....*....|....*...
gi 578817221  719 DQAAAEQLSLVQAELQTQ 736
Cdd:PRK12704  153 EEAKEILLEKVEEEARHE 170

ClpA

COG0542

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...

652-786

2.07e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440308 [Multi-domain] Cd Length: 836 Bit Score: 42.38 E-value: 2.07e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  652 LKVTSLEEELTDLRVEKESLEKnlserkkksaqERSQAEEEIDEirkSYQEELDKLRQLLKKTRvstdqaaaEQLslvqA 731
Cdd:COG0542   404 MEIDSKPEELDELERRLEQLEI-----------EKEALKKEQDE---ASFERLAELRDELAELE--------EEL----E 457

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 578817221  732 ELQTQWEAKCEHL--LASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITA 786
Cdd:COG0542   458 ALKARWEAEKELIeeIQELKEELEQRYGKIPELEKELAELEEELAELAPLLREEVTE 514

tig

TIGR00115

trigger factor; Trigger factor is a ribosome-associated molecular chaperone and is the first ...

110-183

2.17e-03

Pssm-ID: 272913 [Multi-domain] Cd Length: 410 Bit Score: 41.77 E-value: 2.17e-03

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221   110 LDAVLSQ--DLIVADGPAVEVGDSLEVAYTGwlfqnHVLGQVFDSTANKDklLRLKLGSGKVIKGWEDGMLGMKKG 183
Cdd:TIGR00115  131 LERLREQnaTLVPVERGAAEKGDRVTIDFEG-----FIDGEAFEGGKAEN--FSLELGSGQFIPGFEEQLVGMKAG 199

TPR_MLP1_2

pfam07926

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...

659-790

2.30e-03

Pssm-ID: 462316 [Multi-domain] Cd Length: 129 Bit Score: 39.16 E-value: 2.30e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   659 EELTDLRVEKESLEKNLS--ERKKKSAQERSQAEEEI-DEIRKSYQEELdklrqLLKKTRVSTDQAAAEQLSLVQAELQt 735
Cdd:pfam07926    1 AELSSLQSEIKRLKEEAAdaEAQLQKLQEDLEKQAEIaREAQQNYEREL-----VLHAEDIKALQALREELNELKAEIA- 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 578817221   736 QWEAKCEhllaSAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQ 790
Cdd:pfam07926   75 ELKAEAE----SAKAELEESEESWEEQKKELEKELSELEKRIEDLNEQNKLLHDQ 125

EzrA

pfam06160

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...

500-824

2.31e-03

Pssm-ID: 428797 [Multi-domain] Cd Length: 542 Bit Score: 42.15 E-value: 2.31e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   500 QRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT-------ATENTQARVLHAEQEKAK 572
Cdd:pfam06160   85 KKALDEIEELLDDIEEDIKQILEELDELLESEEKNREEVEELKDKYRELRKTLLAnrfsygpAIDELEKQLAEIEEEFSQ 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   573 VTEElaaaTAQVSHLQLKMTAHQ-KKETELQMQLTESLKEtdLLRGQLTKVQAKLSELQETSEQAQskfksekqnRKQLE 651
Cdd:pfam06160  165 FEEL----TESGDYLEAREVLEKlEEETDALEELMEDIPP--LYEELKTELPDQLEELKEGYREME---------EEGYA 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   652 LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQA-EEEIDEI----------RKSYQEELDKLRQLLKKTRVSTDQ 720
Cdd:pfam06160  230 LEHLNVDKEIQQLEEQLEENLALLENLELDEAEEALEEiEERIDQLydllekevdaKKYVEKNLPEIEDYLEHAEEQNKE 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   721 AAAEQLSLVQA-ELQTQWEAKCEHLlasakDEHLQ----QYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHI 795
Cdd:pfam06160  310 LKEELERVQQSyTLNENELERVRGL-----EKQLEelekRYDEIVERLEEKEVAYSELQEELEEILEQLEEIEEEQEEFK 384

                          330       340
                   ....*....|....*....|....*....
gi 578817221   796 KELEknksQMSGVEAAASDPSEKVKKIMN 824
Cdd:pfam06160  385 ESLQ----SLRKDELEAREKLDEFKLELR 409

YkyA

pfam10368

Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein ...

503-635

2.67e-03

Pssm-ID: 431235 [Multi-domain] Cd Length: 185 Bit Score: 40.27 E-value: 2.67e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   503 IQENERLKQEILEKSNRI-EEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE---NTQARVLHAEQEKAK-VTEEL 577
Cdd:pfam10368   27 LVELEKKEQELYEEIIELgMDEFDEIKKLSDEALENVEEREELLEKEKESIEEAKEefkKIKEIIEEIEDEELKkEAEEL 106

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578817221   578 AAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDL----LRGQLTKVQAKLSELQETSEQ 635
Cdd:pfam10368  107 IDAMEERYEAYDELYDAYKKALELDKELYEMLKDEDLtleeLQEQIEKINESYEEVKEANEQ 168

Surf_Exclu_PgrA

TIGR04320

SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ...

610-696

3.51e-03

SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.

Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 40.87 E-value: 3.51e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   610 KETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESL-EKNLSE--RKKKSAQER 686
Cdd:TIGR04320  254 NSLAALQAKLATAQADLAAAQTALNTAQAALTSAQTAYAAAQAALATAQKELANAQAQALQTaQNNLATaqAALANAEAR 333

                           90
                   ....*....|.
gi 578817221   687 -SQAEEEIDEI 696
Cdd:TIGR04320  334 lAKAKEALANL 344

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

685-800

3.66e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 41.44 E-value: 3.66e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  685 ERSQAEEEIDEIRKSYqEELDKLRQLLKKTRVSTD------------QAAAEQLSLVQAELQT--QWEA-KCEHLLASAK 749
Cdd:COG4913   219 EEPDTFEAADALVEHF-DDLERAHEALEDAREQIEllepirelaeryAAARERLAELEYLRAAlrLWFAqRRLELLEAEL 297

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578817221  750 DEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQ--------ITALTKQNEQHIKELEK 800
Cdd:COG4913   298 EELRAELARLEAELERLEARLDALREELDELEAQirgnggdrLEQLEREIERLERELEE 356

PHA03247

large tegument protein UL36; Provisional

883-1053

4.40e-03

large tegument protein UL36; Provisional

Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.46 E-value: 4.40e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  883 RPRRPSQEQSASASSGQPQAPLNRERPesPMVPSEQVVEEAVPLPPQAlttSQDGHRRKGDSEAEALSEIKDGSLPPELS 962
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAAGPPRRLTR--PAVASLSESRESLPSPWDP---ADPPAAVLAPAAALPPAASPAGPLPPPTS 2833

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  963 CIPSHRVLGPPTSIPPEPL-GPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPdgPLQESSTRLSLTSDPEEGDPla 1041
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLgGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP--AVSRSTESFALPPDQPERPP-- 2909

                         170
                  ....*....|..
gi 578817221 1042 lGPESPGEPQPP 1053
Cdd:PHA03247 2910 -QPQAPPPPQPQ 2920

PRK01156

chromosome segregation protein; Provisional

496-799

4.42e-03

chromosome segregation protein; Provisional

Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 41.43 E-value: 4.42e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  496 MSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSlqtatENTQARVLHAEQEKAKVTE 575
Cdd:PRK01156  182 ISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNL-----KSALNELSSLEDMKNRYES 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  576 ELAAATAQVSHLQLKMTAHQKKETELqMQLT---------------------ESLKET-DLLRGQLTKVQA---KLSELQ 630
Cdd:PRK01156  257 EIKTAESDLSMELEKNNYYKELEERH-MKIIndpvyknrnyindyfkykndiENKKQIlSNIDAEINKYHAiikKLSVLQ 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  631 ETSEQAQSKfKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKsaQERSQAeeEIDEIRKSYQEELDKLRQL 710
Cdd:PRK01156  336 KDYNDYIKK-KSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKN--IERMSA--FISEILKIQEIDPDAIKKE 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  711 LKKTRVSTDQAAAEqlslvQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQ-------------RDAYQQKLVQLQEKC 777
Cdd:PRK01156  411 LNEINVKLQDISSK-----VSSLNQRIRALRENLDELSRNMEMLNGQSVCPVcgttlgeeksnhiINHYNEKKSRLEEKI 485

                         330       340
                  ....*....|....*....|..
gi 578817221  778 LALQAQITALTKQNEQHIKELE 799
Cdd:PRK01156  486 REIEIEVKDIDEKIVDLKKRKE 507

PRK11637

AmiB activator; Provisional

509-732

4.46e-03

AmiB activator; Provisional

Pssm-ID: 236942 [Multi-domain] Cd Length: 428 Bit Score: 40.83 E-value: 4.46e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  509 LKQEILEKSNRIEEQNDKISELIERnqryveqsnlmMEKRNNSLQTATentqaRVLHAEQEK-AKVTEELAAATAQVSHL 587
Cdd:PRK11637   52 IQQDIAAKEKSVRQQQQQRASLLAQ-----------LKKQEEAISQAS-----RKLRETQNTlNQLNKQIDELNASIAKL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  588 -------------QLKMTAHQKKETELQMQLT--ESLKETDLLR--GQLTKV-QAKLSELQETSEQAQskfksekQNRKQ 649
Cdd:PRK11637  116 eqqqaaqerllaaQLDAAFRQGEHTGLQLILSgeESQRGERILAyfGYLNQArQETIAELKQTREELA-------AQKAE 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  650 LELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEideirksyQEELDKLRQllKKTRVSTDQAAAEQLSLV 729
Cdd:PRK11637  189 LEEKQSQQKTLLYEQQAQQQKLEQARNERKKTLTGLESSLQKD--------QQQLSELRA--NESRLRDSIARAEREAKA 258


                  ...
gi 578817221  730 QAE 732
Cdd:PRK11637  259 RAE 261

Jnk-SapK_ap_N

pfam09744

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins ...

623-709

4.69e-03

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.

Pssm-ID: 462875 [Multi-domain] Cd Length: 150 Bit Score: 38.75 E-value: 4.69e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   623 QAKLSELQETSEQAQSKFKSEKQNRKQ----LELKVTSLEEELTDLRVEKESLEK-----------NLSERKKKSAQERS 687
Cdd:pfam09744   49 NVELEELREDNEQLETQYEREKALRKRaeeeLEEIEDQWEQETKDLLSQVESLEEenrrleadhvsRLEEKEAELKKEYS 128

                           90       100
                   ....*....|....*....|..
gi 578817221   688 QAEEEIDEIRKSYQEELDKLRQ 709
Cdd:pfam09744  129 KLHERETEVLRKLKEVVDRQRD 150

PRK05771

V-type ATP synthase subunit I; Validated

507-753

4.71e-03

V-type ATP synthase subunit I; Validated

Pssm-ID: 235600 [Multi-domain] Cd Length: 646 Bit Score: 41.07 E-value: 4.71e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  507 ERLKQEI-LEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVlhaEQEKAKVTEELAAATAQVS 585
Cdd:PRK05771   34 EDLKEELsNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDV---EEELEKIEKEIKELEEEIS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  586 HLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQA------KLSELQETSEQAQSKFKSEKQNRK-----QLELKV 654
Cdd:PRK05771  111 ELENEIKELEQEIERLEPWGNFDLDLSLLLGFKYVSVFVgtvpedKLEELKLESDVENVEYISTDKGYVyvvvvVLKELS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  655 TSLEEELTDLRVEKESLEknlseRKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTrvstdqaaaEQLSLVQAELQ 734
Cdd:PRK05771  191 DEVEEELKKLGFERLELE-----EEGTPSELIREIKEELEEIEKERESLLEELKELAKKY---------LEELLALYEYL 256

                         250
                  ....*....|....*....
gi 578817221  735 TQWEAKCEHLLASAKDEHL 753
Cdd:PRK05771  257 EIELERAEALSKFLKTDKT 275

mukB

chromosome partition protein MukB;

496-713

4.91e-03

chromosome partition protein MukB;

Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 41.10 E-value: 4.91e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  496 MSNIQRIIQENERLKQEILEKsnRIEEQNDKISEL------IERNQRYVEQsnlmMEKRNNSLQTATEN---TQARVLHA 566
Cdd:PRK04863  874 LSALNRLLPRLNLLADETLAD--RVEEIREQLDEAeeakrfVQQHGNALAQ----LEPIVSVLQSDPEQfeqLKQDYQQA 947

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  567 EQEKAKVTEELAAATAQVSHLqlkmtAHQKKETELQMqLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKF------ 640
Cdd:PRK04863  948 QQTQRDAKQQAFALTEVVQRR-----AHFSYEDAAEM-LAKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLaqynqv 1021

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  641 ----KSEKQNRKQLelkVTSLEEELTDLRVE-KESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQ---EELDKLRQLLK 712
Cdd:PRK04863 1022 laslKSSYDAKRQM---LQELKQELQDLGVPaDSGAEERARARRDELHARLSANRSRRNQLEKQLTfceAEMDNLTKKLR 1098


                  .
gi 578817221  713 K 713
Cdd:PRK04863 1099 K 1099

tolA_full

TIGR02794

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...

621-844

5.11e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]

Pssm-ID: 274303 [Multi-domain] Cd Length: 346 Bit Score: 40.60 E-value: 5.11e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   621 KVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT--DLRVEKESLEKNLSERKKKSAQERSQAEEEIDEiRK 698
Cdd:TIGR02794   65 KEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQaeQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAE-RK 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   699 SYQEELDKLRQLLKKTRVSTDQAAAEqlslvQAELQTQWEAKcehllasAKDEHLQQYQEVCAQRDAYQQKL---VQLQE 775
Cdd:TIGR02794  144 AKEEAAKQAEEEAKAKAAAEAKKKAE-----EAKKKAEAEAK-------AKAEAEAKAKAEEAKAKAEAAKAkaaAEAAA 211

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578817221   776 KCLALQAQITALTKQ------NEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRT 844
Cdd:TIGR02794  212 KAEAEAAAAAAAEAErkadeaELGDIFGLASGSNAEKQGGARGAAAGSEVDKYAAIIQQAIQQNLYDDPSFRGKT 286

Cast

pfam10174

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...

442-783

5.72e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.

Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 40.96 E-value: 5.72e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   442 TEARQhnTEIRMAVSKVAdKMDHLMTKVEELQKHSAGNSMLIPS--------MSVTMETSMIMSN-IQRIIQENERLKQE 512
Cdd:pfam10174  228 TKALQ--TVIEMKDTKIS-SLERNIRDLEDEVQMLKTNGLLHTEdreeeikqMEVYKSHSKFMKNkIDQLKQELSKKESE 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   513 ILEKSNRIEEQNDKISElierNQRYVE---QSNLMMEKRNNSLQTATENTQARVLHAEQ---EKAK----VTEELAAATA 582
Cdd:pfam10174  305 LLALQTKLETLTNQNSD----CKQHIEvlkESLTAKEQRAAILQTEVDALRLRLEEKESflnKKTKqlqdLTEEKSTLAG 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   583 QVSHLQLKMTAHQKKETELQMQLtESLKEtdllrgQLTKVQAKLSELQEtseqaqskfksekqnrkqlelKVTSLEEELT 662
Cdd:pfam10174  381 EIRDLKDMLDVKERKINVLQKKI-ENLQE------QLRDKDKQLAGLKE---------------------RVKSLQTDSS 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   663 DLRVEKESLEKNLSErkKKSAQERSQaeEEIDEIRKSYQEELDKLRQLLKKTRvstdqaaaEQLSLVQAELQTQweakcE 742
Cdd:pfam10174  433 NTDTALTTLEEALSE--KERIIERLK--EQREREDRERLEELESLKKENKDLK--------EKVSALQPELTEK-----E 495

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 578817221   743 HLLASAKdEHLQQYQEVCAQRDAYQQKL----VQLQEKCLALQAQ 783
Cdd:pfam10174  496 SSLIDLK-EHASSLASSGLKKDSKLKSLeiavEQKKEECSKLENQ 539

DUF4670

pfam15709

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...

504-703

6.03e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.

Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 40.71 E-value: 6.03e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   504 QENERLKQEILEKSNRIEEqndkisELIERNQRYVEQSNLMMEKRNNS--LQTATENTQARVLHAEQEKAKVTEElaaat 581
Cdd:pfam15709  358 EEQRRLQQEQLERAEKMRE------ELELEQQRRFEEIRLRKQRLEEErqRQEEEERKQRLQLQAAQERARQQQE----- 426

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   582 aqvshlqlkmtAHQKKETELQMQlteslketdllrgqltkvqaklsELQETSEQAQskfkSEKQNRKQLELKVT------ 655
Cdd:pfam15709  427 -----------EFRRKLQELQRK-----------------------KQQEEAERAE----AEKQRQKELEMQLAeeqkrl 468

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578817221   656 ---SLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEE 703
Cdd:pfam15709  469 memAEEERLEYQRQKQEAEEKARLEAEERRQKEEEAARLALEEAMKQAQEQ 519

Tig

COG0544

FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, ...

118-183

6.82e-03

FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440310 [Multi-domain] Cd Length: 424 Bit Score: 40.11 E-value: 6.82e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817221  118 LIVADGPAvEVGDSLEVAYTGWlfqnhVLGQVFDSTANKDklLRLKLGSGKVIKGWEDGMLGMKKG 183
Cdd:COG0544   151 LVPVERAA-EEGDRVTIDFEGT-----IDGEEFEGGKAED--YSLELGSGSFIPGFEEQLVGMKAG 208

COG5022

Myosin heavy chain [General function prediction only];

465-708

7.23e-03

Myosin heavy chain [General function prediction only];

Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 40.83 E-value: 7.23e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  465 LMTKVEELQKHSAGNSMLIPSMSVTMETSMIM---SNIQRIIQENERLKQEILEKSN-------RIEEQNDKISELIERN 534
Cdd:COG5022   919 LIENLEFKTELIARLKKLLNNIDLEEGPSIEYvklPELNKLHEVESKLKETSEEYEDllkkstiLVREGNKANSELKNFK 998

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  535 QRYVEQS-NLM-----------MEKRNNSLQTA-----TENTQARVLHAEQE-KAKVTEELAAATAQVSHLQL-KMTAHQ 595
Cdd:COG5022   999 KELAELSkQYGalqestkqlkeLPVEVAELQSAskiisSESTELSILKPLQKlKGLLLLENNQLQARYKALKLrRENSLL 1078

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  596 KKETELQMQLTESL-KETDLLRGQLTKVQ-AKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLE-----EELTDLRVEK 668
Cdd:COG5022  1079 DDKQLYQLESTENLlKTINVKDLEVTNRNlVKPANVLQFIVAQMIKLNLLQEISKFLSQLVNTLEpvfqkLSVLQLELDG 1158

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 578817221  669 ESLEKNLSERKKKSA-----QERSQAEEEIDEIRKSYQEELDKLR 708
Cdd:COG5022  1159 LFWEANLEALPSPPPfaalsEKRLYQSALYDEKSKLSSSEVNDLK 1203

PRK00409

recombination and DNA strand exchange inhibitor protein; Reviewed

600-713

7.23e-03

recombination and DNA strand exchange inhibitor protein; Reviewed

Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 40.58 E-value: 7.23e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  600 ELQMQLTESLKETDLLRGQltkVQAKLSELQETSEQAQSKFKSEKQNRKQlelkvtSLEEELTDLRVEKESLEKNLSERK 679
Cdd:PRK00409  527 ELERELEQKAEEAEALLKE---AEKLKEELEEKKEKLQEEEDKLLEEAEK------EAQQAIKEAKKEADEIIKELRQLQ 597

                          90       100       110
                  ....*....|....*....|....*....|....
gi 578817221  680 KKsaQERSQAEEEIDEIRKSYQEELDKLRQLLKK 713
Cdd:PRK00409  598 KG--GYASVKAHELIEARKRLNKANEKKEKKKKK 629

EzrA

pfam06160

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...

558-835

7.39e-03

Pssm-ID: 428797 [Multi-domain] Cd Length: 542 Bit Score: 40.22 E-value: 7.39e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   558 NTQARVLHAEQEKAK-----VTEELAaataQVSHLQLKMtahqkkETElqmQLTESLKE--TDLLRGQLTKVQAKLSELQ 630
Cdd:pfam06160    7 KIYKEIDELEERKNElmnlpVQEELS----KVKKLNLTG------ETQ---EKFEEWRKkwDDIVTKSLPDIEELLFEAE 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   631 ETSEQaqSKFKSEKQNRKQLELKVTSLEEELTDLRvekESLeKNLSERKKKSAQERSQAEEEIDEIRKSY---------- 700
Cdd:pfam06160   74 ELNDK--YRFKKAKKALDEIEELLDDIEEDIKQIL---EEL-DELLESEEKNREEVEELKDKYRELRKTLlanrfsygpa 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   701 ----QEELDKLRQLLKKTRVSTDQ----AAAEQLSLVQ---AELQTQWEaKCEHLLASAKDEHLQQYQEVcaqRDAYQqk 769
Cdd:pfam06160  148 idelEKQLAEIEEEFSQFEELTESgdylEAREVLEKLEeetDALEELME-DIPPLYEELKTELPDQLEEL---KEGYR-- 221

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817221   770 lvQLQEK-----CLALQAQITALTKQNEQHIKELEKNksQMSGVEAAASDPSEKvkkiMNQVFQSLRREFE 835
Cdd:pfam06160  222 --EMEEEgyaleHLNVDKEIQQLEEQLEENLALLENL--ELDEAEEALEEIEER----IDQLYDLLEKEVD 284

WEMBL

pfam05701

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...

566-839

7.48e-03

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".

Pssm-ID: 461718 [Multi-domain] Cd Length: 562 Bit Score: 40.40 E-value: 7.48e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   566 AEQEKAKVTEELAAATAQVSHLQLKMtahQKKETELQmqltESLKETDLLRGQLTKVQAKLSElqETSEQAQSKFKSEKQ 645
Cdd:pfam05701   61 AEAAKAQVLEELESTKRLIEELKLNL---ERAQTEEA----QAKQDSELAKLRVEEMEQGIAD--EASVAAKAQLEVAKA 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   646 NRKQLELKVTSLEEELTDLRVEKESL--EKNLSERKkksAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAA 723
Cdd:pfam05701  132 RHAAAVAELKSVKEELESLRKEYASLvsERDIAIKR---AEEAVSASKEIEKTVEELTIELIATKESLESAHAAHLEAEE 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   724 EQLSLVQAELQ--TQWEAKCEHllasAKDEHLQQYQEVCAQRDaYQQKLVQLQEKCLALQAQITALT--KQNEQHIKELE 799
Cdd:pfam05701  209 HRIGAALAREQdkLNWEKELKQ----AEEELQRLNQQLLSAKD-LKSKLETASALLLDLKAELAAYMesKLKEEADGEGN 283

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578817221   800 KNKSQMSGVEAAASDPSE--KVK----------KIMNQVFQSLRREFELEES 839
Cdd:pfam05701  284 EKKTSTSIQAALASAKKEleEVKaniekakdevNCLRVAAASLRSELEKEKA 335

HOOK

pfam05622

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...

507-804

7.84e-03

Pssm-ID: 461694 [Multi-domain] Cd Length: 528 Bit Score: 40.06 E-value: 7.84e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   507 ERLKQEILEKSNRIEEQNDKISELIERNQRyveqsnlmMEKRNNSLQTATENtqarvLHAEQEKAKVT-EELAAATAQVS 585
Cdd:pfam05622  186 ETYKRQVQELHGKLSEESKKADKLEFEYKK--------LEEKLEALQKEKER-----LIIERDTLRETnEELRCAQLQQA 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   586 HLQLKMTAHQK-----------------KETELQMQLteslkETDLLR----GQLTKVQAKLSELQETSEQAQSKFksEK 644
Cdd:pfam05622  253 ELSQADALLSPssdpgdnlaaeimpaeiREKLIRLQH-----ENKMLRlgqeGSYRERLTELQQLLEDANRRKNEL--ET 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   645 QNRKQlelkvtslEEELTDLRVEKESLEKNLSERKKK---SAQERSQAEEEIDEIRKSyQEELDKLRQLLKKTRVSTDQA 721
Cdd:pfam05622  326 QNRLA--------NQRILELQQQVEELQKALQEQGSKaedSSLLKQKLEEHLEKLHEA-QSELQKKKEQIEELEPKQDSN 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   722 AAEQLslvqAELQTQWEAKCEHLLASakDEHLQQYQE----VCAQRDAYQQKLVQLQekCLALQAQITALTKQNEQHIKE 797
Cdd:pfam05622  397 LAQKI----DELQEALRKKDEDMKAM--EERYKKYVEkaksVIKTLDPKQNPASPPE--IQALKNQLLEKDKKIEHLERD 468


                   ....*..
gi 578817221   798 LEKNKSQ 804
Cdd:pfam05622  469 FEKSKLQ 475

Casc1_N

pfam15927

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...

658-744

8.29e-03

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.

Pssm-ID: 464947 [Multi-domain] Cd Length: 201 Bit Score: 38.88 E-value: 8.29e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221   658 EEELTDLRVEKEslEKNLSERKKKSAQERSQAEEEiDEIRKsyqEELDKLRQLLKKTRvstdqAAAEQLSLVqAELQTQW 737
Cdd:pfam15927    5 EEEEERLRAEEE--EAERLEEERREEEEEERLAAE-QDRRA---EELEELKHLLEERK-----EALEKLRAE-AREEAEW 72


                   ....*....
gi 578817221   738 E--AKCEHL 744
Cdd:pfam15927   73 EryMRCDGL 81

PHA02562

endonuclease subunit; Provisional

600-823

8.30e-03

endonuclease subunit; Provisional

Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 40.00 E-value: 8.30e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  600 ELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQA----QSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNL 675
Cdd:PHA02562  178 ELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENiarkQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAAL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  676 SERKKKSAQERSQAeEEIDEIRKSYQE-------------ELDKLRQLlkKTRVSTDQAAAEQLSLVQAELQtqwEAKCE 742
Cdd:PHA02562  258 NKLNTAAAKIKSKI-EQFQKVIKMYEKggvcptctqqiseGPDRITKI--KDKLKELQHSLEKLDTAIDELE---EIMDE 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817221  743 HLLASAKdehlqqYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQ---NEQHIKELEKNKSQMSgveaaaSDPSEKV 819
Cdd:PHA02562  332 FNEQSKK------LLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEfvdNAEELAKLQDELDKIV------KTKSELV 399


                  ....
gi 578817221  820 KKIM 823
Cdd:PHA02562  400 KEKY 403

Smc