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Conserved domains on  [gi|578818623|ref|XP_006717588|]
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neuropilin-1 isoform X6 [Homo sapiens]

Protein Classification

CUB domain-containing protein( domain architecture ID 11504393)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
615-775 1.01e-56

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


:

Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 192.19  E-value: 1.01e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  615 CEFGWGShktFCHWEHDNHVQLKW---SVLTSKTGPIQDHT---GDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMT 688
Cdd:pfam00629   1 CDFEDGN---LCGWTQDSSDDFDWervSGPSVKTGPSSDHTqgtGSGHFMYVDTSSGAPGQTARLLSPLLPPSRSPQCLR 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  689 FWYHMSGSHVGTLRVKLRYQKpEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNh 768
Cdd:pfam00629  78 FWYHMSGSGVGTLRVYVRENG-GTLDTLLWSISGDQGPSWKEARVTLSSSTQPFQVVFEGIRGGGSRGGIALDDISLSS- 155

                  ....*..
gi 578818623  769 isqEDCA 775
Cdd:pfam00629 156 ---GPCP 159
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
277-423 1.27e-50

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 174.46  E-value: 1.27e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 277 EALGMESGEiHSDQITASSQYSTNWSAERSRLNYPeNGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKetKKKYYVK 356
Cdd:cd00057    1 EPLGMESGL-ADDQITASSSYSSGWEASRARLNSD-NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGG--GSSEWVT 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578818623 357 TYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYG 423
Cdd:cd00057   77 SYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
DUF3481 pfam11980
C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the ...
810-888 3.05e-46

C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the C-terminus of neuropilins. It represents the transmembrane region of these transmembrane glycoproteins, that are predominantly co-receptors for another class of proteins known as semaphorins. The domain is found associated with pfam00754, pfam00431, pfam00629.


:

Pssm-ID: 403259  Cd Length: 82  Bit Score: 159.65  E-value: 3.05e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578818623  810 RKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA 888
Cdd:pfam11980   4 DKEGSMLKTLDPILITIIAMSALGVLLGAICGVVLYCACSQNGMSDRNLSALENYNFELVDGIKLKKEKMNHQKSYSEA 82
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
27-140 4.92e-39

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 140.63  E-value: 4.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYqRIMINFNpHFDLE-DRDCKYDYVEVFDGENENGHFRGKFCG 105
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGY-RIRLTFE-DFDLEsSPNCSYDYLEIYDGPSTSSPLLGRFCG 78
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 578818623 106 KIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEI 140
Cdd:cd00041   79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
147-264 1.16e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 131.00  E-value: 1.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 147 CSQNYTTP-SGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNppggmfCRYDRLEIWDGFPDVGPHIG 225
Cdd:cd00041    1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN------CSYDYLEIYDGPSTSSPLLG 74
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 578818623 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSV 264
Cdd:cd00041   75 RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
435-582 7.87e-33

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 124.00  E-value: 7.87e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 435 LGMVSGLiSDSQITSSNQGDRNWMPENIRLvTSRSGWalppapHSYIN---EWLQIDLGEEKIVRGIIIQGGKHRENKVF 511
Cdd:cd00057    3 LGMESGL-ADDQITASSSYSSGWEASRARL-NSDNAW------TPAVNdppQWLQVDLGKTRRVTGIQTQGRKGGGSSEW 74
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578818623 512 MRKFKIGYSNNGSDWKMIMDdsKRKAKSFEGNNNYDTPELRTFPA-LSTRFIRIYPeRATHGGLGLRMELLG 582
Cdd:cd00057   75 VTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPpIVARYIRILP-TTWNGNISLRLELYG 143
 
Name Accession Description Interval E-value
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
615-775 1.01e-56

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 192.19  E-value: 1.01e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  615 CEFGWGShktFCHWEHDNHVQLKW---SVLTSKTGPIQDHT---GDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMT 688
Cdd:pfam00629   1 CDFEDGN---LCGWTQDSSDDFDWervSGPSVKTGPSSDHTqgtGSGHFMYVDTSSGAPGQTARLLSPLLPPSRSPQCLR 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  689 FWYHMSGSHVGTLRVKLRYQKpEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNh 768
Cdd:pfam00629  78 FWYHMSGSGVGTLRVYVRENG-GTLDTLLWSISGDQGPSWKEARVTLSSSTQPFQVVFEGIRGGGSRGGIALDDISLSS- 155

                  ....*..
gi 578818623  769 isqEDCA 775
Cdd:pfam00629 156 ---GPCP 159
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
610-769 1.66e-55

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 188.71  E-value: 1.66e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   610 TYGFNCEFGWGshkTFCHWEHDNHVQLKWSVLTSKT---GPIQDHT-GDGNFIYSQADENQKGKVARLVSPVVYSQNSAH 685
Cdd:smart00137   1 TSPGNCDFEEG---STCGWHQDSNDDGHWERVSSATgipGPNRDHTtGNGHFMFFETSSGAEGQTARLLSPPLYENRSTH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   686 CMTFWYHMSGSHVGTLRVKLRyQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISI 765
Cdd:smart00137  78 CLTFWYYMYGSGSGTLNVYVR-ENNGSQDTLLWSRSGTQGGQWLQAEVALSSWPQPFQVVFEGTRGKGHSGYIALDDILL 156

                   ....
gi 578818623   766 NNHI 769
Cdd:smart00137 157 SNGP 160
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
615-768 5.85e-54

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 184.50  E-value: 5.85e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 615 CEFGWGshktFCHWEHDNHVQLKWSVLTSKTGP---IQDHT---GDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMT 688
Cdd:cd06263    1 CDFEDG----LCGWTQDSTDDFDWTRVSGSTPSpgtPPDHThgtGSGHYLYVESSSGREGQKARLLSPLLPPPRSSHCLS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 689 FWYHMSGSHVGTLRVKLRYQKpEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNH 768
Cdd:cd06263   77 FWYHMYGSGVGTLNVYVREEG-GGLGTLLWSASGGQGNQWQEAEVTLSASSKPFQVVFEGVRGSGSRGDIALDDISLSPG 155
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
277-423 1.27e-50

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 174.46  E-value: 1.27e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 277 EALGMESGEiHSDQITASSQYSTNWSAERSRLNYPeNGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKetKKKYYVK 356
Cdd:cd00057    1 EPLGMESGL-ADDQITASSSYSSGWEASRARLNSD-NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGG--GSSEWVT 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578818623 357 TYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYG 423
Cdd:cd00057   77 SYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
DUF3481 pfam11980
C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the ...
810-888 3.05e-46

C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the C-terminus of neuropilins. It represents the transmembrane region of these transmembrane glycoproteins, that are predominantly co-receptors for another class of proteins known as semaphorins. The domain is found associated with pfam00754, pfam00431, pfam00629.


Pssm-ID: 403259  Cd Length: 82  Bit Score: 159.65  E-value: 3.05e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578818623  810 RKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA 888
Cdd:pfam11980   4 DKEGSMLKTLDPILITIIAMSALGVLLGAICGVVLYCACSQNGMSDRNLSALENYNFELVDGIKLKKEKMNHQKSYSEA 82
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
27-140 4.92e-39

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 140.63  E-value: 4.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYqRIMINFNpHFDLE-DRDCKYDYVEVFDGENENGHFRGKFCG 105
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGY-RIRLTFE-DFDLEsSPNCSYDYLEIYDGPSTSSPLLGRFCG 78
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 578818623 106 KIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEI 140
Cdd:cd00041   79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
274-424 7.61e-39

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 141.11  E-value: 7.61e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   274 KCMEALGMESgeihSDQITASSQYstnWSAERSRLNY-PENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKK 352
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---WAAKIARLNGgSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVT 73
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578818623   353 YYvktykIDVSSNGEDWITIKEGNKPVlFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGC 424
Cdd:smart00231  74 YK-----LEYSDDGVNWTTYKDGNSKV-FPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
CUB pfam00431
CUB domain;
27-138 5.21e-38

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 137.43  E-value: 5.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   27 CGDTIKiESPGYLTSPGYPHSYHPSEKCEWLIQAPdPYQRIMINFnPHFDLED-RDCKYDYVEVFDGENENGHFRGKFCG 105
Cdd:pfam00431   1 CGGVLT-DSSGSISSPNYPNPYPPNKDCVWLIRAP-PGFRVKLTF-QDFELEDhDECGYDYVEIRDGPSASSPLLGRFCG 77
                          90       100       110
                  ....*....|....*....|....*....|...
gi 578818623  106 KIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRY 138
Cdd:pfam00431  78 SGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
147-264 1.16e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 131.00  E-value: 1.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 147 CSQNYTTP-SGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNppggmfCRYDRLEIWDGFPDVGPHIG 225
Cdd:cd00041    1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN------CSYDYLEIYDGPSTSSPLLG 74
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 578818623 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSV 264
Cdd:cd00041   75 RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
435-582 7.87e-33

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 124.00  E-value: 7.87e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 435 LGMVSGLiSDSQITSSNQGDRNWMPENIRLvTSRSGWalppapHSYIN---EWLQIDLGEEKIVRGIIIQGGKHRENKVF 511
Cdd:cd00057    3 LGMESGL-ADDQITASSSYSSGWEASRARL-NSDNAW------TPAVNdppQWLQVDLGKTRRVTGIQTQGRKGGGSSEW 74
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578818623 512 MRKFKIGYSNNGSDWKMIMDdsKRKAKSFEGNNNYDTPELRTFPA-LSTRFIRIYPeRATHGGLGLRMELLG 582
Cdd:cd00057   75 VTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPpIVARYIRILP-TTWNGNISLRLELYG 143
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
156-262 1.21e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 121.73  E-value: 1.21e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   156 GVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNppggmfCRYDRLEIWDGFPDVGPHIGRYCGQKTPGR 235
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDN------CEYDYVEIYDGPSASSPLLGRFCGSEAPPP 74
                           90       100
                   ....*....|....*....|....*...
gi 578818623   236 IRSSSG-ILSMVFYTDSAIAKEGFSANY 262
Cdd:smart00042  75 VISSSSnSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
37-138 7.65e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 119.42  E-value: 7.65e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623    37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYqRIMINFNpHFDLE-DRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSS 115
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGY-RIELQFT-DFDLEsSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISS 78
                           90       100
                   ....*....|....*....|....
gi 578818623   116 -GPFLFIKFVSDYETHGAGFSIRY 138
Cdd:smart00042  79 sSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
147-262 1.69e-31

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 118.94  E-value: 1.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSnppggmFCRYDRLEIWDGFPDVGPHIGR 226
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHD------ECGYDYVEIRDGPSASSPLLGR 74
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 578818623  227 YCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
Cdd:pfam00431  75 FCGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
290-421 3.88e-25

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 101.37  E-value: 3.88e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  290 QITASSQYSTNWSAErSRLN-YPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISketKKKYYVKTYKIDVSSNGED 368
Cdd:pfam00754   1 QITASSSYSGEGPAA-AALDgDPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD---GSNGYVTSYKIEYSLDGEN 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578818623  369 WITIKEGNkpvlFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETG--ISMRFEV 421
Cdd:pfam00754  77 WTTVKDEK----IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGngIALRAEL 127
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
446-580 5.35e-25

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 100.98  E-value: 5.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  446 QITSSNQGDRNWMPENIRLVTSRSGWAlppAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENkVFMRKFKIGYSNNGSD 525
Cdd:pfam00754   1 QITASSSYSGEGPAAAALDGDPNTAWS---AWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSN-GYVTSYKIEYSLDGEN 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 578818623  526 WKMIMDDskrkakSFEGNNNYDTPELRTF-PALSTRFIRIYP-ERATHGGLGLRMEL 580
Cdd:pfam00754  77 WTTVKDE------KIPGNNDNNTPVTNTFdPPIKARYVRIVPtSWNGGNGIALRAEL 127
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
430-583 4.74e-21

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 89.88  E-value: 4.74e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   430 PCSGMLGMVSglisDSQITSSNQGdrnWMPENIRL-VTSRSGW--ALPPAPHsyineWLQIDLGEEKIVRGIIIQGGKHR 506
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---WAAKIARLnGGSDGGWcpAKNDLPP-----WIQVDLGRLRTVTGVITGRRHGN 68
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578818623   507 ENKVfmrKFKIGYSNNGSDWKMIMDdskRKAKSFEGNNNYDTPELRTFPA-LSTRFIRIYPeRATHGGLGLRMELLGC 583
Cdd:smart00231  69 GDWV---TYKLEYSDDGVNWTTYKD---GNSKVFPGNSDAGTVVLNDFPPpIVARYVRILP-TGWNGNIILRVELLGC 139
 
Name Accession Description Interval E-value
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
615-775 1.01e-56

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 192.19  E-value: 1.01e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  615 CEFGWGShktFCHWEHDNHVQLKW---SVLTSKTGPIQDHT---GDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMT 688
Cdd:pfam00629   1 CDFEDGN---LCGWTQDSSDDFDWervSGPSVKTGPSSDHTqgtGSGHFMYVDTSSGAPGQTARLLSPLLPPSRSPQCLR 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  689 FWYHMSGSHVGTLRVKLRYQKpEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNh 768
Cdd:pfam00629  78 FWYHMSGSGVGTLRVYVRENG-GTLDTLLWSISGDQGPSWKEARVTLSSSTQPFQVVFEGIRGGGSRGGIALDDISLSS- 155

                  ....*..
gi 578818623  769 isqEDCA 775
Cdd:pfam00629 156 ---GPCP 159
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
610-769 1.66e-55

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 188.71  E-value: 1.66e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   610 TYGFNCEFGWGshkTFCHWEHDNHVQLKWSVLTSKT---GPIQDHT-GDGNFIYSQADENQKGKVARLVSPVVYSQNSAH 685
Cdd:smart00137   1 TSPGNCDFEEG---STCGWHQDSNDDGHWERVSSATgipGPNRDHTtGNGHFMFFETSSGAEGQTARLLSPPLYENRSTH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   686 CMTFWYHMSGSHVGTLRVKLRyQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISI 765
Cdd:smart00137  78 CLTFWYYMYGSGSGTLNVYVR-ENNGSQDTLLWSRSGTQGGQWLQAEVALSSWPQPFQVVFEGTRGKGHSGYIALDDILL 156

                   ....
gi 578818623   766 NNHI 769
Cdd:smart00137 157 SNGP 160
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
615-768 5.85e-54

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 184.50  E-value: 5.85e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 615 CEFGWGshktFCHWEHDNHVQLKWSVLTSKTGP---IQDHT---GDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMT 688
Cdd:cd06263    1 CDFEDG----LCGWTQDSTDDFDWTRVSGSTPSpgtPPDHThgtGSGHYLYVESSSGREGQKARLLSPLLPPPRSSHCLS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 689 FWYHMSGSHVGTLRVKLRYQKpEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNH 768
Cdd:cd06263   77 FWYHMYGSGVGTLNVYVREEG-GGLGTLLWSASGGQGNQWQEAEVTLSASSKPFQVVFEGVRGSGSRGDIALDDISLSPG 155
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
277-423 1.27e-50

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 174.46  E-value: 1.27e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 277 EALGMESGEiHSDQITASSQYSTNWSAERSRLNYPeNGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKetKKKYYVK 356
Cdd:cd00057    1 EPLGMESGL-ADDQITASSSYSSGWEASRARLNSD-NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGG--GSSEWVT 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578818623 357 TYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYG 423
Cdd:cd00057   77 SYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
DUF3481 pfam11980
C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the ...
810-888 3.05e-46

C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the C-terminus of neuropilins. It represents the transmembrane region of these transmembrane glycoproteins, that are predominantly co-receptors for another class of proteins known as semaphorins. The domain is found associated with pfam00754, pfam00431, pfam00629.


Pssm-ID: 403259  Cd Length: 82  Bit Score: 159.65  E-value: 3.05e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578818623  810 RKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA 888
Cdd:pfam11980   4 DKEGSMLKTLDPILITIIAMSALGVLLGAICGVVLYCACSQNGMSDRNLSALENYNFELVDGIKLKKEKMNHQKSYSEA 82
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
27-140 4.92e-39

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 140.63  E-value: 4.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYqRIMINFNpHFDLE-DRDCKYDYVEVFDGENENGHFRGKFCG 105
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGY-RIRLTFE-DFDLEsSPNCSYDYLEIYDGPSTSSPLLGRFCG 78
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 578818623 106 KIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEI 140
Cdd:cd00041   79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
274-424 7.61e-39

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 141.11  E-value: 7.61e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   274 KCMEALGMESgeihSDQITASSQYstnWSAERSRLNY-PENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKK 352
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---WAAKIARLNGgSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVT 73
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578818623   353 YYvktykIDVSSNGEDWITIKEGNKPVlFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGC 424
Cdd:smart00231  74 YK-----LEYSDDGVNWTTYKDGNSKV-FPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
CUB pfam00431
CUB domain;
27-138 5.21e-38

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 137.43  E-value: 5.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   27 CGDTIKiESPGYLTSPGYPHSYHPSEKCEWLIQAPdPYQRIMINFnPHFDLED-RDCKYDYVEVFDGENENGHFRGKFCG 105
Cdd:pfam00431   1 CGGVLT-DSSGSISSPNYPNPYPPNKDCVWLIRAP-PGFRVKLTF-QDFELEDhDECGYDYVEIRDGPSASSPLLGRFCG 77
                          90       100       110
                  ....*....|....*....|....*....|...
gi 578818623  106 KIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRY 138
Cdd:pfam00431  78 SGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
147-264 1.16e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 131.00  E-value: 1.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 147 CSQNYTTP-SGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNppggmfCRYDRLEIWDGFPDVGPHIG 225
Cdd:cd00041    1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN------CSYDYLEIYDGPSTSSPLLG 74
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 578818623 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSV 264
Cdd:cd00041   75 RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
435-582 7.87e-33

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 124.00  E-value: 7.87e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623 435 LGMVSGLiSDSQITSSNQGDRNWMPENIRLvTSRSGWalppapHSYIN---EWLQIDLGEEKIVRGIIIQGGKHRENKVF 511
Cdd:cd00057    3 LGMESGL-ADDQITASSSYSSGWEASRARL-NSDNAW------TPAVNdppQWLQVDLGKTRRVTGIQTQGRKGGGSSEW 74
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578818623 512 MRKFKIGYSNNGSDWKMIMDdsKRKAKSFEGNNNYDTPELRTFPA-LSTRFIRIYPeRATHGGLGLRMELLG 582
Cdd:cd00057   75 VTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPpIVARYIRILP-TTWNGNISLRLELYG 143
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
156-262 1.21e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 121.73  E-value: 1.21e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   156 GVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNppggmfCRYDRLEIWDGFPDVGPHIGRYCGQKTPGR 235
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDN------CEYDYVEIYDGPSASSPLLGRFCGSEAPPP 74
                           90       100
                   ....*....|....*....|....*...
gi 578818623   236 IRSSSG-ILSMVFYTDSAIAKEGFSANY 262
Cdd:smart00042  75 VISSSSnSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
37-138 7.65e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 119.42  E-value: 7.65e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623    37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYqRIMINFNpHFDLE-DRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSS 115
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGY-RIELQFT-DFDLEsSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISS 78
                           90       100
                   ....*....|....*....|....
gi 578818623   116 -GPFLFIKFVSDYETHGAGFSIRY 138
Cdd:smart00042  79 sSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
147-262 1.69e-31

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 118.94  E-value: 1.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSnppggmFCRYDRLEIWDGFPDVGPHIGR 226
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHD------ECGYDYVEIRDGPSASSPLLGR 74
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 578818623  227 YCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
Cdd:pfam00431  75 FCGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
290-421 3.88e-25

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 101.37  E-value: 3.88e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  290 QITASSQYSTNWSAErSRLN-YPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISketKKKYYVKTYKIDVSSNGED 368
Cdd:pfam00754   1 QITASSSYSGEGPAA-AALDgDPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD---GSNGYVTSYKIEYSLDGEN 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578818623  369 WITIKEGNkpvlFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETG--ISMRFEV 421
Cdd:pfam00754  77 WTTVKDEK----IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGngIALRAEL 127
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
446-580 5.35e-25

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 100.98  E-value: 5.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623  446 QITSSNQGDRNWMPENIRLVTSRSGWAlppAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENkVFMRKFKIGYSNNGSD 525
Cdd:pfam00754   1 QITASSSYSGEGPAAAALDGDPNTAWS---AWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSN-GYVTSYKIEYSLDGEN 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 578818623  526 WKMIMDDskrkakSFEGNNNYDTPELRTF-PALSTRFIRIYP-ERATHGGLGLRMEL 580
Cdd:pfam00754  77 WTTVKDE------KIPGNNDNNTPVTNTFdPPIKARYVRIVPtSWNGGNGIALRAEL 127
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
430-583 4.74e-21

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 89.88  E-value: 4.74e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578818623   430 PCSGMLGMVSglisDSQITSSNQGdrnWMPENIRL-VTSRSGW--ALPPAPHsyineWLQIDLGEEKIVRGIIIQGGKHR 506
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---WAAKIARLnGGSDGGWcpAKNDLPP-----WIQVDLGRLRTVTGVITGRRHGN 68
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578818623   507 ENKVfmrKFKIGYSNNGSDWKMIMDdskRKAKSFEGNNNYDTPELRTFPA-LSTRFIRIYPeRATHGGLGLRMELLGC 583
Cdd:smart00231  69 GDWV---TYKLEYSDDGVNWTTYKD---GNSKVFPGNSDAGTVVLNDFPPpIVARYVRILP-TGWNGNIILRVELLGC 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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