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Conserved domains on  [gi|578822922|ref|XP_006719162|]
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retroelement silencing factor 1 isoform X2 [Homo sapiens]

Protein Classification

retroelement silencing factor 1( domain architecture ID 12173327)

retroelement silencing factor 1 (RESF1) is a DUF4617 domain-containing protein that plays a role in the regulation of imprinted gene expression, and regulates repressive epigenetic modifications associated with SETDB1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4617 pfam15395
Domain of unknown function (DUF4617); This family of proteins is found in eukaryotes. Proteins ...
 669-1668 0e+00

Domain of unknown function (DUF4617); This family of proteins is found in eukaryotes. Proteins in this family are typically between 702 and 1745 amino acids in length.


:

Pssm-ID: 464702  Cd Length: 1086  Bit Score: 1443.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   669 SMEVLATCLSLWKKQP--SDTAKEKECDKLRTNTTAVGISKPANIHVKSPCSVVGNSnsQNKISNPSQQTALSMVMHNYE 746
Cdd:pfam15395    1 SMELLATCLSLWKKQPseSESTEEKQCNESRTNTTIVGLSKPTNVCIKSPCSVVGNS--QNKLLNSSQETVLPMVVQNHE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   747 SSGINITKGTELQIAVVSPLVLSEVKTLSVKGITPAVLPETVYPVIKEGSVCSLQNQLAENAKATAALKVDVSGPVASTA 826
Cdd:pfam15395   79 SSGANLTKGTELQIAVVSPLILSDVKTLSVKDITPEALPETVYPVIKEGSICSLQNQLAENVLVTAALKVDVNEPVASST 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   827 TSTKIFPLTQKEKQNESTNGNSEVTPNVNQGKHNKLESAIHSPMNDQQISQESRNSTVVSSDTLQIDNICSLVEGDTSYN 906
Cdd:pfam15395  159 TSTKIFPLIQKEKQNKSTNGNSEGTPNTNQGKHFELESKDHCPVSDQQVSQKSRDSTVVSSDMLQIDSICSLVEGDVSYN 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   907 SQIAKIFSSLPLKMVEPQKPSLPNQQGIGSREPEKQLDNTTENKDFGFQKDKPVQCTDVSHKICDQSKSEPPLE-SSFNN 985
Cdd:pfam15395  239 SQIAKIFNSVPLEQVEPQKPSLPSQQVISDRRQKEQLDNTTENKDLLFQKDESVQCTDVSHEILDQSKSLQPPEsSSLKN 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   986 LETNRVILEKSSLEHATEK-STANDTCSSAAIQEDIYPQEIDASSNYTPQDPARNEIHSDKAPVLYLHDQLSELLKEFPY 1064
Cdd:pfam15395  319 VEANRGSEEESKLEHSTKKeSTALDVCSSAAIQQDLAPQEIDSLSSYTAQDPTKNEILDDATPILYLHDQLSELLKEFPY 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1065 GIEAVNTREGSVGQQTTYQTSEDQTADKTSSDSKDPADQIQITILSSEQMKEIFPEQDDQPYVVDKLAEPQKEEPITEVV 1144
Cdd:pfam15395  399 GIEGVNRRNDSVAQQKTNQISKDQTCSKKSCDSKDPTDQIQITILNSEQMKELFPEQDDQPSEVDKLAEPQKEKPVTEEG 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1145 SQCDLQAPAAGQSRDSVILDSEKDDIHCCALGWLSMVYEGVPQCQCNSIKNSSSEEEKQKEQCSPLDTNSCKQGERTSDR 1224
Cdd:pfam15395  479 SQCDPQAPKEGESPDSVSLDSEKDDIHCCALGWLSMVYEGVPQCQCNSIKNSASKEEKGKDQCSPLETNSCKQGENTSDS 558

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1225 DVTvVQFKSLVNNPK---TPPDGKSHFPELQ-DDSRKDTPKTKHKSLPRTEQELVAGQFSSKCDK-LNPLQNHKRK-KLR 1298
Cdd:pfam15395  559 DAP-VKFNSVSNNPKtplTPPVEKNHFPEIQgNKCYKDTSKTKSNSSLRTEQKPLPGQLSSKCDKdLDSLQSHKRKeKLQ 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1299 FHEVTFHSSNKMTASYEQASQETRQKKHVTQNSRPLKTKTAFLP--NKDVYKKHSSLGQSLSPEKIKLKLKSVSFKQ--- 1373
Cdd:pfam15395  638 FHEVTFQSSKKMMKFSDQKSQESLQRKHLSQNSGPLKAKTVFLSskNKDLCRKNSSLVQSVSPEKLKLKFKADGHKQkkl 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1374 -KRKLDQGNVLDMEVKKKKHDKQEQKGSVG-ATFKLGDSLSNPNERAIVKEKMVSNTKSVDTKASSSKFSRILTPKEYLQ 1451
Cdd:pfam15395  718 eKRKIDQGEILDGEIKKKKNDKQEQNKNVGpGTFKLCNLLSNPNERASVKEKTVSNVKSSDSKDSSSKSNRVITPQEYLQ 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1452 RQKHKEALSNKASKKICVKNVPCDSEHMRPSKLAVQVESCGKSNEKHSSGVQTSKESLNGLTSHGKNLKIHHSQESKTYn 1531
Cdd:pfam15395  798 RQKHKEAIGKKASKKTCVENVPCDSEHMKNSKLSMQVISCGKSNEKQGSNVQTSKESLNIYLSHGKNLKIHHSEESKTH- 876

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1532 ILRNVKEKVGGKQPDKiWIDKTKLDK-LTNISNEAQFSQMPPQVKDQKKLYLNRVGFKCTERESISLTKLESSPRKLHKD 1610
Cdd:pfam15395  877 SSRNKKGTLDGKQPDK-WIDKTKSDKnLLNINNETERSQLSLQAKEQRKQYLNRVAFKCTERESICLTKLDSSPRKLSKE 955

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1611 --KRQENKHKTFLPVKGNTEKSNMLEFKLCPDILLKNTNSVEERKDVKPHPRkEQAPLQV 1668
Cdd:pfam15395  956 sgKSQENKPKTSLPVKDTTEKPSMLEFKLCPDILFKNTNTVEEQKDLKNPPR-EQAPVQV 1014
 
Name Accession Description Interval E-value
DUF4617 pfam15395
Domain of unknown function (DUF4617); This family of proteins is found in eukaryotes. Proteins ...
 669-1668 0e+00

Domain of unknown function (DUF4617); This family of proteins is found in eukaryotes. Proteins in this family are typically between 702 and 1745 amino acids in length.


Pssm-ID: 464702  Cd Length: 1086  Bit Score: 1443.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   669 SMEVLATCLSLWKKQP--SDTAKEKECDKLRTNTTAVGISKPANIHVKSPCSVVGNSnsQNKISNPSQQTALSMVMHNYE 746
Cdd:pfam15395    1 SMELLATCLSLWKKQPseSESTEEKQCNESRTNTTIVGLSKPTNVCIKSPCSVVGNS--QNKLLNSSQETVLPMVVQNHE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   747 SSGINITKGTELQIAVVSPLVLSEVKTLSVKGITPAVLPETVYPVIKEGSVCSLQNQLAENAKATAALKVDVSGPVASTA 826
Cdd:pfam15395   79 SSGANLTKGTELQIAVVSPLILSDVKTLSVKDITPEALPETVYPVIKEGSICSLQNQLAENVLVTAALKVDVNEPVASST 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   827 TSTKIFPLTQKEKQNESTNGNSEVTPNVNQGKHNKLESAIHSPMNDQQISQESRNSTVVSSDTLQIDNICSLVEGDTSYN 906
Cdd:pfam15395  159 TSTKIFPLIQKEKQNKSTNGNSEGTPNTNQGKHFELESKDHCPVSDQQVSQKSRDSTVVSSDMLQIDSICSLVEGDVSYN 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   907 SQIAKIFSSLPLKMVEPQKPSLPNQQGIGSREPEKQLDNTTENKDFGFQKDKPVQCTDVSHKICDQSKSEPPLE-SSFNN 985
Cdd:pfam15395  239 SQIAKIFNSVPLEQVEPQKPSLPSQQVISDRRQKEQLDNTTENKDLLFQKDESVQCTDVSHEILDQSKSLQPPEsSSLKN 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   986 LETNRVILEKSSLEHATEK-STANDTCSSAAIQEDIYPQEIDASSNYTPQDPARNEIHSDKAPVLYLHDQLSELLKEFPY 1064
Cdd:pfam15395  319 VEANRGSEEESKLEHSTKKeSTALDVCSSAAIQQDLAPQEIDSLSSYTAQDPTKNEILDDATPILYLHDQLSELLKEFPY 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1065 GIEAVNTREGSVGQQTTYQTSEDQTADKTSSDSKDPADQIQITILSSEQMKEIFPEQDDQPYVVDKLAEPQKEEPITEVV 1144
Cdd:pfam15395  399 GIEGVNRRNDSVAQQKTNQISKDQTCSKKSCDSKDPTDQIQITILNSEQMKELFPEQDDQPSEVDKLAEPQKEKPVTEEG 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1145 SQCDLQAPAAGQSRDSVILDSEKDDIHCCALGWLSMVYEGVPQCQCNSIKNSSSEEEKQKEQCSPLDTNSCKQGERTSDR 1224
Cdd:pfam15395  479 SQCDPQAPKEGESPDSVSLDSEKDDIHCCALGWLSMVYEGVPQCQCNSIKNSASKEEKGKDQCSPLETNSCKQGENTSDS 558

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1225 DVTvVQFKSLVNNPK---TPPDGKSHFPELQ-DDSRKDTPKTKHKSLPRTEQELVAGQFSSKCDK-LNPLQNHKRK-KLR 1298
Cdd:pfam15395  559 DAP-VKFNSVSNNPKtplTPPVEKNHFPEIQgNKCYKDTSKTKSNSSLRTEQKPLPGQLSSKCDKdLDSLQSHKRKeKLQ 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1299 FHEVTFHSSNKMTASYEQASQETRQKKHVTQNSRPLKTKTAFLP--NKDVYKKHSSLGQSLSPEKIKLKLKSVSFKQ--- 1373
Cdd:pfam15395  638 FHEVTFQSSKKMMKFSDQKSQESLQRKHLSQNSGPLKAKTVFLSskNKDLCRKNSSLVQSVSPEKLKLKFKADGHKQkkl 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1374 -KRKLDQGNVLDMEVKKKKHDKQEQKGSVG-ATFKLGDSLSNPNERAIVKEKMVSNTKSVDTKASSSKFSRILTPKEYLQ 1451
Cdd:pfam15395  718 eKRKIDQGEILDGEIKKKKNDKQEQNKNVGpGTFKLCNLLSNPNERASVKEKTVSNVKSSDSKDSSSKSNRVITPQEYLQ 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1452 RQKHKEALSNKASKKICVKNVPCDSEHMRPSKLAVQVESCGKSNEKHSSGVQTSKESLNGLTSHGKNLKIHHSQESKTYn 1531
Cdd:pfam15395  798 RQKHKEAIGKKASKKTCVENVPCDSEHMKNSKLSMQVISCGKSNEKQGSNVQTSKESLNIYLSHGKNLKIHHSEESKTH- 876

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1532 ILRNVKEKVGGKQPDKiWIDKTKLDK-LTNISNEAQFSQMPPQVKDQKKLYLNRVGFKCTERESISLTKLESSPRKLHKD 1610
Cdd:pfam15395  877 SSRNKKGTLDGKQPDK-WIDKTKSDKnLLNINNETERSQLSLQAKEQRKQYLNRVAFKCTERESICLTKLDSSPRKLSKE 955

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1611 --KRQENKHKTFLPVKGNTEKSNMLEFKLCPDILLKNTNSVEERKDVKPHPRkEQAPLQV 1668
Cdd:pfam15395  956 sgKSQENKPKTSLPVKDTTEKPSMLEFKLCPDILFKNTNTVEEQKDLKNPPR-EQAPVQV 1014
 
Name Accession Description Interval E-value
DUF4617 pfam15395
Domain of unknown function (DUF4617); This family of proteins is found in eukaryotes. Proteins ...
 669-1668 0e+00

Domain of unknown function (DUF4617); This family of proteins is found in eukaryotes. Proteins in this family are typically between 702 and 1745 amino acids in length.


Pssm-ID: 464702  Cd Length: 1086  Bit Score: 1443.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   669 SMEVLATCLSLWKKQP--SDTAKEKECDKLRTNTTAVGISKPANIHVKSPCSVVGNSnsQNKISNPSQQTALSMVMHNYE 746
Cdd:pfam15395    1 SMELLATCLSLWKKQPseSESTEEKQCNESRTNTTIVGLSKPTNVCIKSPCSVVGNS--QNKLLNSSQETVLPMVVQNHE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   747 SSGINITKGTELQIAVVSPLVLSEVKTLSVKGITPAVLPETVYPVIKEGSVCSLQNQLAENAKATAALKVDVSGPVASTA 826
Cdd:pfam15395   79 SSGANLTKGTELQIAVVSPLILSDVKTLSVKDITPEALPETVYPVIKEGSICSLQNQLAENVLVTAALKVDVNEPVASST 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   827 TSTKIFPLTQKEKQNESTNGNSEVTPNVNQGKHNKLESAIHSPMNDQQISQESRNSTVVSSDTLQIDNICSLVEGDTSYN 906
Cdd:pfam15395  159 TSTKIFPLIQKEKQNKSTNGNSEGTPNTNQGKHFELESKDHCPVSDQQVSQKSRDSTVVSSDMLQIDSICSLVEGDVSYN 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   907 SQIAKIFSSLPLKMVEPQKPSLPNQQGIGSREPEKQLDNTTENKDFGFQKDKPVQCTDVSHKICDQSKSEPPLE-SSFNN 985
Cdd:pfam15395  239 SQIAKIFNSVPLEQVEPQKPSLPSQQVISDRRQKEQLDNTTENKDLLFQKDESVQCTDVSHEILDQSKSLQPPEsSSLKN 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922   986 LETNRVILEKSSLEHATEK-STANDTCSSAAIQEDIYPQEIDASSNYTPQDPARNEIHSDKAPVLYLHDQLSELLKEFPY 1064
Cdd:pfam15395  319 VEANRGSEEESKLEHSTKKeSTALDVCSSAAIQQDLAPQEIDSLSSYTAQDPTKNEILDDATPILYLHDQLSELLKEFPY 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1065 GIEAVNTREGSVGQQTTYQTSEDQTADKTSSDSKDPADQIQITILSSEQMKEIFPEQDDQPYVVDKLAEPQKEEPITEVV 1144
Cdd:pfam15395  399 GIEGVNRRNDSVAQQKTNQISKDQTCSKKSCDSKDPTDQIQITILNSEQMKELFPEQDDQPSEVDKLAEPQKEKPVTEEG 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1145 SQCDLQAPAAGQSRDSVILDSEKDDIHCCALGWLSMVYEGVPQCQCNSIKNSSSEEEKQKEQCSPLDTNSCKQGERTSDR 1224
Cdd:pfam15395  479 SQCDPQAPKEGESPDSVSLDSEKDDIHCCALGWLSMVYEGVPQCQCNSIKNSASKEEKGKDQCSPLETNSCKQGENTSDS 558

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1225 DVTvVQFKSLVNNPK---TPPDGKSHFPELQ-DDSRKDTPKTKHKSLPRTEQELVAGQFSSKCDK-LNPLQNHKRK-KLR 1298
Cdd:pfam15395  559 DAP-VKFNSVSNNPKtplTPPVEKNHFPEIQgNKCYKDTSKTKSNSSLRTEQKPLPGQLSSKCDKdLDSLQSHKRKeKLQ 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1299 FHEVTFHSSNKMTASYEQASQETRQKKHVTQNSRPLKTKTAFLP--NKDVYKKHSSLGQSLSPEKIKLKLKSVSFKQ--- 1373
Cdd:pfam15395  638 FHEVTFQSSKKMMKFSDQKSQESLQRKHLSQNSGPLKAKTVFLSskNKDLCRKNSSLVQSVSPEKLKLKFKADGHKQkkl 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1374 -KRKLDQGNVLDMEVKKKKHDKQEQKGSVG-ATFKLGDSLSNPNERAIVKEKMVSNTKSVDTKASSSKFSRILTPKEYLQ 1451
Cdd:pfam15395  718 eKRKIDQGEILDGEIKKKKNDKQEQNKNVGpGTFKLCNLLSNPNERASVKEKTVSNVKSSDSKDSSSKSNRVITPQEYLQ 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1452 RQKHKEALSNKASKKICVKNVPCDSEHMRPSKLAVQVESCGKSNEKHSSGVQTSKESLNGLTSHGKNLKIHHSQESKTYn 1531
Cdd:pfam15395  798 RQKHKEAIGKKASKKTCVENVPCDSEHMKNSKLSMQVISCGKSNEKQGSNVQTSKESLNIYLSHGKNLKIHHSEESKTH- 876

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1532 ILRNVKEKVGGKQPDKiWIDKTKLDK-LTNISNEAQFSQMPPQVKDQKKLYLNRVGFKCTERESISLTKLESSPRKLHKD 1610
Cdd:pfam15395  877 SSRNKKGTLDGKQPDK-WIDKTKSDKnLLNINNETERSQLSLQAKEQRKQYLNRVAFKCTERESICLTKLDSSPRKLSKE 955

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578822922  1611 --KRQENKHKTFLPVKGNTEKSNMLEFKLCPDILLKNTNSVEERKDVKPHPRkEQAPLQV 1668
Cdd:pfam15395  956 sgKSQENKPKTSLPVKDTTEKPSMLEFKLCPDILFKNTNTVEEQKDLKNPPR-EQAPVQV 1014
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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