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Conserved domains on  [gi|578825987|ref|XP_006720276|]
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proteasome activator complex subunit 2 isoform X1 [Homo sapiens]

Protein Classification

proteasome activator 28 family protein( domain architecture ID 10491459)

proteasome activator 28 (PA28) family protein similar to Dictyostelium discoideum PA28, a subunit of the 11S REG proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PA28_beta pfam02252
Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of ...
 16-160 1.40e-74

Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


:

Pssm-ID: 460508  Cd Length: 145  Bit Score: 219.31  E-value: 1.40e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825987   16 FLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERG 95
Cdd:pfam02252   1 LVPSNKKIVELLEVLKPEIRELIEDCNLVKMWIQLLIPKIEDGNNFGVSIQEEVLAELTRVEESAANFLDQISKYFLSRA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578825987   96 DAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPS 160
Cdd:pfam02252  81 KIVSKVAKYPHVEDYRRALRELDEKEYISLRLVLLDLRNNYATLYDLIHKNIEKIKKPRSSNGGS 145
 
Name Accession Description Interval E-value
PA28_beta pfam02252
Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of ...
 16-160 1.40e-74

Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


Pssm-ID: 460508  Cd Length: 145  Bit Score: 219.31  E-value: 1.40e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825987   16 FLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERG 95
Cdd:pfam02252   1 LVPSNKKIVELLEVLKPEIRELIEDCNLVKMWIQLLIPKIEDGNNFGVSIQEEVLAELTRVEESAANFLDQISKYFLSRA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578825987   96 DAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPS 160
Cdd:pfam02252  81 KIVSKVAKYPHVEDYRRALRELDEKEYISLRLVLLDLRNNYATLYDLIHKNIEKIKKPRSSNGGS 145
 
Name Accession Description Interval E-value
PA28_beta pfam02252
Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of ...
 16-160 1.40e-74

Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


Pssm-ID: 460508  Cd Length: 145  Bit Score: 219.31  E-value: 1.40e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825987   16 FLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERG 95
Cdd:pfam02252   1 LVPSNKKIVELLEVLKPEIRELIEDCNLVKMWIQLLIPKIEDGNNFGVSIQEEVLAELTRVEESAANFLDQISKYFLSRA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578825987   96 DAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPS 160
Cdd:pfam02252  81 KIVSKVAKYPHVEDYRRALRELDEKEYISLRLVLLDLRNNYATLYDLIHKNIEKIKKPRSSNGGS 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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