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Conserved domains on  [gi|578835938|ref|XP_006723832|]
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pre-mRNA-processing factor 6 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRP1_N pfam06424
PRP1 splicing factor, N-terminal; This domain is specific to the N-terminal part of the prp1 ...
 13-169 1.38e-48

PRP1 splicing factor, N-terminal; This domain is specific to the N-terminal part of the prp1 splicing factor, which is involved in mRNA splicing (and possibly also poly(A)+ RNA nuclear export and cell cycle progression). This domain is specific to the N terminus of the RNA splicing factor encoded by prp1. It is involved in mRNA splicing and possibly also poly(A)and RNA nuclear export and cell cycle progression.


:

Pssm-ID: 461908  Cd Length: 109  Bit Score: 167.32  E-value: 1.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938   13 APLGYVPGLGRGATGFTTrsdigpardandpvddrhappgkrtvgdqmkknqaaddddedlndtnyDEFNGYAGSLFSSG 92
Cdd:pfam06424   1 APPGYVAGLGRGATGFTT------------------------------------------------DEFEGYDGGLFAGG 32

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578835938   93 PYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNK 169
Cdd:pfam06424  33 PYDKDDEEADRIYEAIDERMDERRKKRREAREKEELEKYRAERPKIQQQFADLKRGLATVSEEEWANIPEVGDLTRK 109
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 547-798 7.45e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 87.48  E-value: 7.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 547 LAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPT--------ARVFMKSVKLEwvqdni 618
Cdd:COG2956   20 LNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDraeallelAQDYLKAGLLD------ 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 619 rAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRL 698
Cdd:COG2956   94 -RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 699 KNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKC---EHDPHVLLAVA 775
Cdd:COG2956  173 LDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKAlelDPSDDLLLALA 252

                        250       260
                 ....*....|....*....|...
gi 578835938 776 KLFWSQRKITKAREWFHRTVKID 798
Cdd:COG2956  253 DLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo super family cl37187
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 289-773 2.00e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


The actual alignment was detected with superfamily member TIGR02917:

Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 61.25  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  289 NDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAA--RLQPGD------TAKA 360
Cdd:TIGR02917 173 NRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALAtiLIEAGEfeeaekHADA 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  361 VVAQAVRHlPQSVR----IYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVed 436
Cdd:TIGR02917 253 LLKKAPNS-PLAHYlkalVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSH-- 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  437 aeecdragsvatcQAV-MRAVIGIGIEEEDRKHTWMEDADSCVAHNAL---------------ECARAIYAYALQVFPSK 500
Cdd:TIGR02917 330 -------------QARrLLASIQLRLGRVDEAIATLSPALGLDPDDPAalsllgeaylalgdfEKAAEYLAKATELDPEN 396

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  501 KSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLES 580
Cdd:TIGR02917 397 AAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYL 476

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  581 ENDEYERARRLLAKARSSAP---TARVFMksVKLEWVQDNIRAAQDLCEEALRHYedfPK----------LWMMKGQIEE 647
Cdd:TIGR02917 477 GKGDLAKAREAFEKALSIEPdffPAAANL--ARIDIQEGNPDDAIQRFEKVLTID---PKnlrailalagLYLRTGNEEE 551

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  648 QKEMMEKAREAYNQGLKkcphstpLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLM 727
Cdd:TIGR02917 552 AVAWLEKAAELNPQEIE-------PALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSF 624

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 578835938  728 AKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKC-EHDPHVLLA 773
Cdd:TIGR02917 625 KKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRAlELKPDNTEA 671
 
Name Accession Description Interval E-value
PRP1_N pfam06424
PRP1 splicing factor, N-terminal; This domain is specific to the N-terminal part of the prp1 ...
 13-169 1.38e-48

PRP1 splicing factor, N-terminal; This domain is specific to the N-terminal part of the prp1 splicing factor, which is involved in mRNA splicing (and possibly also poly(A)+ RNA nuclear export and cell cycle progression). This domain is specific to the N terminus of the RNA splicing factor encoded by prp1. It is involved in mRNA splicing and possibly also poly(A)and RNA nuclear export and cell cycle progression.


Pssm-ID: 461908  Cd Length: 109  Bit Score: 167.32  E-value: 1.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938   13 APLGYVPGLGRGATGFTTrsdigpardandpvddrhappgkrtvgdqmkknqaaddddedlndtnyDEFNGYAGSLFSSG 92
Cdd:pfam06424   1 APPGYVAGLGRGATGFTT------------------------------------------------DEFEGYDGGLFAGG 32

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578835938   93 PYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNK 169
Cdd:pfam06424  33 PYDKDDEEADRIYEAIDERMDERRKKRREAREKEELEKYRAERPKIQQQFADLKRGLATVSEEEWANIPEVGDLTRK 109
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 547-798 7.45e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 87.48  E-value: 7.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 547 LAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPT--------ARVFMKSVKLEwvqdni 618
Cdd:COG2956   20 LNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDraeallelAQDYLKAGLLD------ 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 619 rAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRL 698
Cdd:COG2956   94 -RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 699 KNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKC---EHDPHVLLAVA 775
Cdd:COG2956  173 LDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKAlelDPSDDLLLALA 252

                        250       260
                 ....*....|....*....|...
gi 578835938 776 KLFWSQRKITKAREWFHRTVKID 798
Cdd:COG2956  253 DLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 289-773 2.00e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 61.25  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  289 NDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAA--RLQPGD------TAKA 360
Cdd:TIGR02917 173 NRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALAtiLIEAGEfeeaekHADA 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  361 VVAQAVRHlPQSVR----IYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVed 436
Cdd:TIGR02917 253 LLKKAPNS-PLAHYlkalVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSH-- 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  437 aeecdragsvatcQAV-MRAVIGIGIEEEDRKHTWMEDADSCVAHNAL---------------ECARAIYAYALQVFPSK 500
Cdd:TIGR02917 330 -------------QARrLLASIQLRLGRVDEAIATLSPALGLDPDDPAalsllgeaylalgdfEKAAEYLAKATELDPEN 396

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  501 KSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLES 580
Cdd:TIGR02917 397 AAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYL 476

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  581 ENDEYERARRLLAKARSSAP---TARVFMksVKLEWVQDNIRAAQDLCEEALRHYedfPK----------LWMMKGQIEE 647
Cdd:TIGR02917 477 GKGDLAKAREAFEKALSIEPdffPAAANL--ARIDIQEGNPDDAIQRFEKVLTID---PKnlrailalagLYLRTGNEEE 551

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  648 QKEMMEKAREAYNQGLKkcphstpLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLM 727
Cdd:TIGR02917 552 AVAWLEKAAELNPQEIE-------PALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSF 624

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 578835938  728 AKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKC-EHDPHVLLA 773
Cdd:TIGR02917 625 KKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRAlELKPDNTEA 671
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 289-435 1.10e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 289 NDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAAR--LQPGDTAKAVVA--Q 364
Cdd:COG2956   90 GLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAElyLEQGDYDEAIEAleK 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578835938 365 AVRHLPQSVRIYIRAAELET---DIRAKKRVLRKALEHVPNSV----RLWKAAVELEEPEDARIMLSRAVECCPTSVE 435
Cdd:COG2956  170 ALKLDPDCARALLLLAELYLeqgDYEEAIAALERALEQDPDYLpalpRLAELYEKLGDPEEALELLRKALELDPSDDL 247
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 515-800 1.72e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  515 GTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGdvpAARSILALAFQANPNSEEiwLAAVKLESENDEY------ERA 588
Cdd:TIGR02917  70 GDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQG---KFQQVLDELPGKTLLDDE--GAAELLALRGLAYlglgqlELA 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  589 RRLLAKARSSAPT-ARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCP 667
Cdd:TIGR02917 145 QKSYEQALAIDPRsLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRP 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  668 -HSTPLWLLLSRLEEKiGQLTRARAILEKSRLKNPKNPGlwlesvrleyraglknianTLMAKALqecpnsgILWSEAIF 746
Cdd:TIGR02917 225 nNIAVLLALATILIEA-GEFEEAEKHADALLKKAPNSPL-------------------AHYLKAL-------VDFQKKNY 277

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578835938  747 LEArpqrRTKSVDALKKC-EHDPHVLLAVAKLFwSQRKITKAREWFHRTVKIDSD 800
Cdd:TIGR02917 278 EDA----RETLQDALKSApEYLPALLLAGASEY-QLGNLEQAYQYLNQILKYAPN 327
TPR_19 pfam14559
Tetratricopeptide repeat;
548-600 1.01e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 38.33  E-value: 1.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578835938  548 AGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAP 600
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADP 53
HAT smart00386
HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and ...
 652-682 1.29e-03

HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and sequentially thought to be similar to TPRs.


Pssm-ID: 214642 [Multi-domain]  Cd Length: 33  Bit Score: 37.14  E-value: 1.29e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 578835938   652 MEKAREAYNQGLKKCPHSTPLWLLLSRLEEK 682
Cdd:smart00386   3 IERARKIYERALEKFPKSVELWLKYAEFEER 33
HAT smart00386
HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and ...
 484-513 8.74e-03

HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and sequentially thought to be similar to TPRs.


Pssm-ID: 214642 [Multi-domain]  Cd Length: 33  Bit Score: 34.45  E-value: 8.74e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 578835938   484 ECARAIYAYALQVFPSKKSVWLRAAYFEKN 513
Cdd:smart00386   4 ERARKIYERALEKFPKSVELWLKYAEFEER 33
 
Name Accession Description Interval E-value
PRP1_N pfam06424
PRP1 splicing factor, N-terminal; This domain is specific to the N-terminal part of the prp1 ...
 13-169 1.38e-48

PRP1 splicing factor, N-terminal; This domain is specific to the N-terminal part of the prp1 splicing factor, which is involved in mRNA splicing (and possibly also poly(A)+ RNA nuclear export and cell cycle progression). This domain is specific to the N terminus of the RNA splicing factor encoded by prp1. It is involved in mRNA splicing and possibly also poly(A)and RNA nuclear export and cell cycle progression.


Pssm-ID: 461908  Cd Length: 109  Bit Score: 167.32  E-value: 1.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938   13 APLGYVPGLGRGATGFTTrsdigpardandpvddrhappgkrtvgdqmkknqaaddddedlndtnyDEFNGYAGSLFSSG 92
Cdd:pfam06424   1 APPGYVAGLGRGATGFTT------------------------------------------------DEFEGYDGGLFAGG 32

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578835938   93 PYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNK 169
Cdd:pfam06424  33 PYDKDDEEADRIYEAIDERMDERRKKRREAREKEELEKYRAERPKIQQQFADLKRGLATVSEEEWANIPEVGDLTRK 109
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 547-798 7.45e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 87.48  E-value: 7.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 547 LAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPT--------ARVFMKSVKLEwvqdni 618
Cdd:COG2956   20 LNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDraeallelAQDYLKAGLLD------ 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 619 rAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRL 698
Cdd:COG2956   94 -RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 699 KNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKC---EHDPHVLLAVA 775
Cdd:COG2956  173 LDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKAlelDPSDDLLLALA 252

                        250       260
                 ....*....|....*....|...
gi 578835938 776 KLFWSQRKITKAREWFHRTVKID 798
Cdd:COG2956  253 DLLERKEGLEAALALLERQLRRH 275
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 486-733 1.32e-18

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 86.71  E-value: 1.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 486 ARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQAN 565
Cdd:COG2956   27 AIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 566 PNSEEIWLAAVKLESENDEYERARRLLAKARSSAPT-ARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQ 644
Cdd:COG2956  107 PDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEnAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAE 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 645 IEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPgLWLESVRLEYRAGLKNIAN 724
Cdd:COG2956  187 LYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDD-LLLALADLLERKEGLEAAL 265


                 ....*....
gi 578835938 725 TLMAKALQE 733
Cdd:COG2956  266 ALLERQLRR 274
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 639-838 4.87e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.53  E-value: 4.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 639 WMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAG 718
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 719 LKNIANTLMAKALQECPNSgilwSEAIFLEARPQRRTKSVD--------ALKKCEHDPHVLLAVAKLFWSQRKITKAREW 790
Cdd:COG2956   91 LLDRAEELLEKLLELDPDD----AEALRLLAEIYEQEGDWEkaievlerLLKLGPENAHAYCELAELYLEQGDYDEAIEA 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 578835938 791 FHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPRHGEL 838
Cdd:COG2956  167 LEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPA 214
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 599-737 3.09e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.83  E-value: 3.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 599 APTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSR 678
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 578835938 679 LEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNS 737
Cdd:COG4783   81 ALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 289-773 2.00e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 61.25  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  289 NDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAA--RLQPGD------TAKA 360
Cdd:TIGR02917 173 NRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALAtiLIEAGEfeeaekHADA 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  361 VVAQAVRHlPQSVR----IYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVed 436
Cdd:TIGR02917 253 LLKKAPNS-PLAHYlkalVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSH-- 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  437 aeecdragsvatcQAV-MRAVIGIGIEEEDRKHTWMEDADSCVAHNAL---------------ECARAIYAYALQVFPSK 500
Cdd:TIGR02917 330 -------------QARrLLASIQLRLGRVDEAIATLSPALGLDPDDPAalsllgeaylalgdfEKAAEYLAKATELDPEN 396

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  501 KSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLES 580
Cdd:TIGR02917 397 AAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYL 476

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  581 ENDEYERARRLLAKARSSAP---TARVFMksVKLEWVQDNIRAAQDLCEEALRHYedfPK----------LWMMKGQIEE 647
Cdd:TIGR02917 477 GKGDLAKAREAFEKALSIEPdffPAAANL--ARIDIQEGNPDDAIQRFEKVLTID---PKnlrailalagLYLRTGNEEE 551

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  648 QKEMMEKAREAYNQGLKkcphstpLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLM 727
Cdd:TIGR02917 552 AVAWLEKAAELNPQEIE-------PALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSF 624

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 578835938  728 AKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKC-EHDPHVLLA 773
Cdd:TIGR02917 625 KKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRAlELKPDNTEA 671
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 341-740 3.86e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 60.48  E-value: 3.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  341 KSEDVWLEAAR--LQPGDTAKAVV--AQAVRHLP--QSVRIYIRAAELET-DIRAKKRVLRKALEHVPNSVrlwKAAVEL 413
Cdd:TIGR02917  20 QSPEELIEAAKsyLQKNKYKAAIIqlKNALQKDPndAEARFLLGKIYLALgDYAAAEKELRKALSLGYPKN---QVLPLL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  414 eepedARIMLS-RAVECCPTSVEDAEECDRAGsvatcQAVMRAVIGIGieeedrkhtwmedadsCVAHNALECARAIYAY 492
Cdd:TIGR02917  97 -----ARAYLLqGKFQQVLDELPGKTLLDDEG-----AAELLALRGLA----------------YLGLGQLELAQKSYEQ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  493 ALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIW 572
Cdd:TIGR02917 151 ALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  573 LAAVKLESENDEYERARR----LLAKARSSaPTARvFMKSVkLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQ 648
Cdd:TIGR02917 231 LALATILIEAGEFEEAEKhadaLLKKAPNS-PLAH-YLKAL-VDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQ 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  649 KEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLwLESVRLEY-RAGLKNIANTLM 727
Cdd:TIGR02917 308 LGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAA-LSLLGEAYlALGDFEKAAEYL 386

                         410
                  ....*....|...
gi 578835938  728 AKALQECPNSGIL 740
Cdd:TIGR02917 387 AKATELDPENAAA 399
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 289-435 1.10e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 289 NDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAAR--LQPGDTAKAVVA--Q 364
Cdd:COG2956   90 GLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAElyLEQGDYDEAIEAleK 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578835938 365 AVRHLPQSVRIYIRAAELET---DIRAKKRVLRKALEHVPNSV----RLWKAAVELEEPEDARIMLSRAVECCPTSVE 435
Cdd:COG2956  170 ALKLDPDCARALLLLAELYLeqgDYEEAIAALERALEQDPDYLpalpRLAELYEKLGDPEEALELLRKALELDPSDDL 247
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 558-681 3.89e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.70  E-value: 3.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 558 LALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPT--------ARVFMKsvklewvQDNIRAAQDLCEEAL 629
Cdd:COG4235    6 LRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDnadalldlAEALLA-------AGDTEEAEELLERAL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578835938 630 RHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEE 681
Cdd:COG4235   79 ALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 346-632 8.07e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.74  E-value: 8.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 346 WLEAAR--LQPGDTAKAVVA--QAVRHLPQSVRIYIRAAEL-----ETDiRAKkRVLRKALEHVPNSVRLW----KAAVE 412
Cdd:COG2956   11 WYFKGLnyLLNGQPDKAIDLleEALELDPETVEAHLALGNLyrrrgEYD-RAI-RIHQKLLERDPDRAEALlelaQDYLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 413 LEEPEDARIMLSRAVECCPTSVEdaeecdragsvatcqaVMRAVIGIGIEEEDrkhtWmedadscvaHNALECARAiyay 492
Cdd:COG2956   89 AGLLDRAEELLEKLLELDPDDAE----------------ALRLLAEIYEQEGD----W---------EKAIEVLER---- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 493 ALQVFPSKKSVWLRAA--YFEKNHgtRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEE 570
Cdd:COG2956  136 LLKLGPENAHAYCELAelYLEQGD--YDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLP 213

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578835938 571 IWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHY 632
Cdd:COG2956  214 ALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 639-763 1.66e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.35  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 639 WMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAG 718
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 578835938 719 LKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKK 763
Cdd:COG4783   87 DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEK 131
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 289-595 1.67e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.58  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 289 NDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARlqpgdtakavvaqavrh 368
Cdd:COG2956   22 GQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQ----------------- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 369 lpqsvrIYIRAAELEtdiRAKKrVLRKALEHVPNSVRLWKAAVEL----EEPEDARIMLSRAVECCPTSVedaeecdrag 444
Cdd:COG2956   85 ------DYLKAGLLD---RAEE-LLEKLLELDPDDAEALRLLAEIyeqeGDWEKAIEVLERLLKLGPENA---------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 445 svatcqavmravigigieeedrkHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALL 524
Cdd:COG2956  145 -----------------------HAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAAL 201

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578835938 525 QRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEiWLAAVKLESENDEYERARRLLAKA 595
Cdd:COG2956  202 ERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL-LLALADLLERKEGLEAALALLERQ 271
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 468-800 1.89e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.00  E-value: 1.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 468 HTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAyfeknhgtresLEALLQRAVAHCPKAEVLWLmgakskwl 547
Cdd:COG3914    2 AAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALG-----------LALLLLAALAEAAAAALLAL-------- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 548 AGDVPAARSILALAFQANPNSEEIWLAavklesENDEYERARRLLAKARSSAPT-ARVFMKSVKLEWVQDNIRAAQDLCE 626
Cdd:COG3914   63 AAGEAAAAAAALLLLAALLELAALLLQ------ALGRYEEALALYRRALALNPDnAEALFNLGNLLLALGRLEEALAALR 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 627 EALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGL 706
Cdd:COG3914  137 RALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 707 WLESVRLEYRAGLKNIANTLmAKALQECPNSGILWSEAIFLEARpqrrtksvdalkkcEHDPHVLLAVAKLFWSQRKITK 786
Cdd:COG3914  217 HSNLLFALRQACDWEVYDRF-EELLAALARGPSELSPFALLYLP--------------DDDPAELLALARAWAQLVAAAA 281

                        330
                 ....*....|....
gi 578835938 787 AREWFHRTVKIDSD 800
Cdd:COG3914  282 APELPPPPNPRDPD 295
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
615-763 2.60e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.70  E-value: 2.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 615 QDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILE 694
Cdd:COG0457   21 LGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYD 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578835938 695 KSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKK 763
Cdd:COG0457  101 KALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEK 169
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
563-733 5.78e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.55  E-value: 5.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 563 QANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPT-ARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMM 641
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDdAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 642 KGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKN 721
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYE 161

                        170
                 ....*....|..
gi 578835938 722 IANTLMAKALQE 733
Cdd:COG0457  162 EALELLEKLEAA 173
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 470-600 7.33e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.42  E-value: 7.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 470 WMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAG 549
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578835938 550 DVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAP 600
Cdd:COG4783   87 DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
COG5191 COG5191
Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat [General function ...
 628-714 9.54e-07

Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat [General function prediction only];


Pssm-ID: 227518 [Multi-domain]  Cd Length: 435  Bit Score: 52.27  E-value: 9.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 628 ALRHYEDfPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLE-EKIGQLTRARAILEKSRLKNPKNPGL 706
Cdd:COG5191  100 TNKFFND-PKIWSQYAAYVIKKKMYGEMKNIFAECLTKHPLNVDLWIYCCAFElFEIANIESSRAMFLKGLRMNSRSPRI 178


                 ....*...
gi 578835938 707 WLESVRLE 714
Cdd:COG5191  179 WIEYFRME 186
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 552-701 1.20e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.19  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 552 PAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSVKLEWV---QDNIRAAQDLCEEA 628
Cdd:COG5010    1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLynkLGDFEESLALLEQA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578835938 629 LRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNP 701
Cdd:COG5010   81 LQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 620-750 1.71e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.08  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 620 AAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLK 699
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578835938 700 NPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSgilwSEAIFLEAR 750
Cdd:COG4235   81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD----APARLLEAS 127
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 581-735 3.70e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 47.65  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 581 ENDEYERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEqkemmekAREAYN 660
Cdd:COG5010    6 GFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEE-------SLALLE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578835938 661 QGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECP 735
Cdd:COG5010   79 QALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 506-736 1.11e-05

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 48.37  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 506 RAAYFEKNHGTREsleALLQRAVAHCPKAEVLWLMgAKSKWL--AGDVPAARSILALAFQANPNSEEIWLAAVKLESEND 583
Cdd:COG3071   58 RAAQALGDYERRD---EYLAQALELAPEAELAVLL-TRAELLldQGQAEQALATLEALRAGAPRHPQVLRLLLQAYRQLG 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 584 EYERARRLLAK-ARSSAPTARVFmKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIE-------EQKEMMEKA 655
Cdd:COG3071  134 DWEELLELLPAlRKHKALSAEEA-QALERRAYLGLLRQAARDAEALKALWKALPRAERRDPELAaayaralIALGDHDEA 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 656 REAYNQGLKKCPHSTpLWLLLSRLEekIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECP 735
Cdd:COG3071  213 ERLLREALKRQWDPR-LVRLYGRLQ--GGDPAKQLKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRP 289


                 .
gi 578835938 736 N 736
Cdd:COG3071  290 S 290
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 508-806 1.64e-05

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 47.98  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 508 AYFEKNHGTREsleALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEE-IWLAAVKLESENDEYE 586
Cdd:COG3071   26 ALAEGRYARAE---KLLSKAAEHSEAPLLAYLLAARAAQALGDYERRDEYLAQALELAPEAELaVLLTRAELLLDQGQAE 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 587 RARRLLAKARSSAPtarvfmksvklewvqDNIRAAQdLCEEALRHYEDFPKLW-----MMKGQIEEQKEMMEKAREAYNQ 661
Cdd:COG3071  103 QALATLEALRAGAP---------------RHPQVLR-LLLQAYRQLGDWEELLellpaLRKHKALSAEEAQALERRAYLG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 662 GLKKCPHSTP----LWLLLSRLEEKigqltraraileksrlknpkNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNS 737
Cdd:COG3071  167 LLRQAARDAEalkaLWKALPRAERR--------------------DPELAAAYARALIALGDHDEAERLLREALKRQWDP 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578835938 738 GILwseAIFLEARPQRRTKSV----DALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDlGDAWA 806
Cdd:COG3071  227 RLV---RLYGRLQGGDPAKQLkraeKWLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRPS-AEAYA 295
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 515-800 1.72e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  515 GTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGdvpAARSILALAFQANPNSEEiwLAAVKLESENDEY------ERA 588
Cdd:TIGR02917  70 GDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQG---KFQQVLDELPGKTLLDDE--GAAELLALRGLAYlglgqlELA 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  589 RRLLAKARSSAPT-ARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCP 667
Cdd:TIGR02917 145 QKSYEQALAIDPRsLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRP 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  668 -HSTPLWLLLSRLEEKiGQLTRARAILEKSRLKNPKNPGlwlesvrleyraglknianTLMAKALqecpnsgILWSEAIF 746
Cdd:TIGR02917 225 nNIAVLLALATILIEA-GEFEEAEKHADALLKKAPNSPL-------------------AHYLKAL-------VDFQKKNY 277

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578835938  747 LEArpqrRTKSVDALKKC-EHDPHVLLAVAKLFwSQRKITKAREWFHRTVKIDSD 800
Cdd:TIGR02917 278 EDA----RETLQDALKSApEYLPALLLAGASEY-QLGNLEQAYQYLNQILKYAPN 327
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 502-669 2.99e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.80  E-value: 2.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 502 SVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESE 581
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 582 NDEYERARRLLakarssaptarvfmksvklewvqdniraaqdlcEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQ 661
Cdd:COG4783   85 AGDYDEALALL---------------------------------EKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEK 131


                 ....*...
gi 578835938 662 GLKKCPHS 669
Cdd:COG4783  132 ALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
615-702 4.60e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.85  E-value: 4.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 615 QDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKArEAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILE 694
Cdd:COG3063    5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83


                 ....*...
gi 578835938 695 KSRLKNPK 702
Cdd:COG3063   84 RALELDPS 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
634-835 6.09e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.38  E-value: 6.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 634 DFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLesvrl 713
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN----- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 714 eyraglkNIANTLMAKALQEcpnsgilwsEAIFLEARpqrrtksvdALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHR 793
Cdd:COG0457   81 -------NLGLALQALGRYE---------EALEDYDK---------ALELDPDDAEALYNLGLALLELGRYDEAIEAYER 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 578835938 794 TVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPRH 835
Cdd:COG0457  136 ALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAA 177
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
521-723 7.30e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.38  E-value: 7.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 521 EALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKA---RS 597
Cdd:COG0457   28 IEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKAlelDP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 598 SAPTARVFMKSVKLEwvQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLS 677
Cdd:COG0457  108 DDAEALYNLGLALLE--LGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGE 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578835938 678 RLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIA 723
Cdd:COG0457  186 AALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLL 231
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 483-695 4.32e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.92  E-value: 4.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  483 LECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAF 562
Cdd:TIGR02917 515 PDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAA 594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938  563 QANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAP-TARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMM 641
Cdd:TIGR02917 595 DAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPdSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIG 674

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578835938  642 KGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEK 695
Cdd:TIGR02917 675 LAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRK 728
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 486-602 4.58e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 4.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 486 ARAIYAYALQVFPSKKSVWLRAAYFEKNHgtRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQAN 565
Cdd:COG5010   41 ELAAAGRDKLAKAFAIESPSDNLYNKLGD--FEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALS 118

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 578835938 566 PNSEEIWLAAVKLESENDEYERARRLLAKARSSAPTA 602
Cdd:COG5010  119 PDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSPLK 155
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
645-736 5.28e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.77  E-value: 5.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 645 IEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAiLEKSRLKNPKNPGLWLESVRLEYRAGLKNIAN 724
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                         90
                 ....*....|..
gi 578835938 725 TLMAKALQECPN 736
Cdd:COG3063   80 AYLERALELDPS 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 289-428 9.20e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 9.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 289 NDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVArnlimkgtemcpksEDVWLEAARLQPgdtakavvaQAVRH 368
Cdd:COG2956  158 GDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEA--------------IAALERALEQDP---------DYLPA 214

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578835938 369 LPQSVRIYIRAAELEtdirAKKRVLRKALEHVPNS---VRLWKAAVELEEPEDARIMLSRAVE 428
Cdd:COG2956  215 LPRLAELYEKLGDPE----EALELLRKALELDPSDdllLALADLLERKEGLEAALALLERQLR 273
TPR_19 pfam14559
Tetratricopeptide repeat;
548-600 1.01e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 38.33  E-value: 1.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578835938  548 AGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAP 600
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADP 53
HAT smart00386
HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and ...
 652-682 1.29e-03

HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and sequentially thought to be similar to TPRs.


Pssm-ID: 214642 [Multi-domain]  Cd Length: 33  Bit Score: 37.14  E-value: 1.29e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 578835938   652 MEKAREAYNQGLKKCPHSTPLWLLLSRLEEK 682
Cdd:smart00386   3 IERARKIYERALEKFPKSVELWLKYAEFEER 33
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 288-403 1.65e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 288 INDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAA----RLQPGDTAKAVVA 363
Cdd:COG4783   17 AGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGlallKAGDYDEALALLE 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 578835938 364 QAVRHLPQSVRIYIRAAELETDIRAKKR---VLRKALEHVPNS 403
Cdd:COG4783   97 KALKLDPEHPEAYLRLARAYRALGRPDEaiaALEKALELDPDD 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 615-704 2.05e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 615 QDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILE 694
Cdd:COG4235   30 LGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQ 109

                         90
                 ....*....|
gi 578835938 695 KSRLKNPKNP 704
Cdd:COG4235  110 KLLALLPADA 119
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 650-764 4.50e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 4.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835938 650 EMMEKAREAynqgLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAK 729
Cdd:COG4235    1 EAIARLRQA----LAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLER 76

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 578835938 730 ALQECPNSGILWSEAIFLEARPQRRTKSVDALKKC 764
Cdd:COG4235   77 ALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKL 111
HAT smart00386
HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and ...
 484-513 8.74e-03

HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and sequentially thought to be similar to TPRs.


Pssm-ID: 214642 [Multi-domain]  Cd Length: 33  Bit Score: 34.45  E-value: 8.74e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 578835938   484 ECARAIYAYALQVFPSKKSVWLRAAYFEKN 513
Cdd:smart00386   4 ERARKIYERALEKFPKSVELWLKYAEFEER 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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