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Conserved domains on  [gi|578836130|ref|XP_006723914|]
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dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [Homo sapiens]

Protein Classification

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2( domain architecture ID 10530727)

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 is a subunit of the oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an Asn residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ribophorin_II pfam05817
Oligosaccharyltransferase subunit Ribophorin II; This family contains eukaryotic Ribophorin II ...
9-608 0e+00

Oligosaccharyltransferase subunit Ribophorin II; This family contains eukaryotic Ribophorin II (RPN2) proteins. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylation of newly synthesized polypeptides, and is composed of the following proteins: ribophorins I and II (RI and RII), OST48, and Dadl, N33/IAP, OST4, STT3. The family also includes the SWP1 protein from yeast. In yeast the oligosaccharyltransferase complex is composed 7 or 8 subunits, SWP1, being one of them.


:

Pssm-ID: 461749  Cd Length: 624  Bit Score: 695.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130    9 VFLLALTIIASTWALTPTHYLTKHDVERLKASL--DRPFTNLESAFYSIVGLSSLGAQVPDAKkaCTYIRS---NLDPSN 83
Cdd:pfam05817   1 LLLLLLLLAATASALTVSSYLTDSDRSRLLSVFesGLPSSDLESAYYALSGLQLLGADVPDNQ--CKFLVKllaSSSLSD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130   84 VDSLFYAAQASQALsGCEISISNETKDLLLAAV-SEDSSVTQIYHAVAALSGFGLPLASQEALSALTARLSKEETVLArv 162
Cdd:pfam05817  79 LESLFYALSANKAL-KCSIKLPESVQSALKAALqKEDSSTSDLYYAVGSLKLLGLKIDAAKVVKALTALLKKDDSLES-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  163 wstvlesrslfskrTVQALQTASHLSQQADLRSIVEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEP 242
Cdd:pfam05817 156 --------------LGYALGIASQLDQGADLKFIFSRIEDAVVQADEVDGKYLQFEGGLSTTALVVRGIYKLADAVGKKP 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  243 SIKEDQVIQLMNAIFSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLSQPLTQATVK 322
Cdd:pfam05817 222 PITEDQAVKLANYFLSRKSVQTVKGAFNLLEALKTLSSNKFHIPVVVSLEGTALLSTKKPVLKVRVTNVLGKPLPPLTVK 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  323 LEHAKSVASRATVLQKTSFTPVGDVFELNFMNVKFSSGYYDFLVEV--EGDNRYIAN-TVELRVKISTEVGITNVDLSTV 399
Cdd:pfam05817 302 LESASSTSSDAVVLSKQELKPDATVYELDLLSLKPDRGIYTFDISAssAHDKRLAGNnSVTLKVKVTGEVKVENAEIGVA 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  400 DKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFEL 479
Cdd:pfam05817 382 DSDQSIAPKKQKVDYPSKLKKSLEADSHQKLRLSFALVDVNTGKPFTPHQAFVRLTHQKTKQEVIFVAEPDSSKAYKFDL 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  480 DTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEE--APSTVLSQNLFTPKQEIQ-------------- 543
Cdd:pfam05817 462 DLGGLAKDFGYLSGTYEVELIVGDATLENPILWNVGDVELKFPEEPekAPSPPDPKSLYGPKPEIKhlfrepekrpprvv 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  544 ------------------WIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMFQTLKYLAILGSVTFLAGNRML 605
Cdd:pfam05817 542 sdtftglvlapllillvlWLKLGVNLSNFPFSLSAILFHLGLGAILLLYVLFWLQLNMFTTLKYLALLGIFTFLAGNRLL 621

                  ...
gi 578836130  606 AQQ 608
Cdd:pfam05817 622 SHL 624
 
Name Accession Description Interval E-value
Ribophorin_II pfam05817
Oligosaccharyltransferase subunit Ribophorin II; This family contains eukaryotic Ribophorin II ...
9-608 0e+00

Oligosaccharyltransferase subunit Ribophorin II; This family contains eukaryotic Ribophorin II (RPN2) proteins. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylation of newly synthesized polypeptides, and is composed of the following proteins: ribophorins I and II (RI and RII), OST48, and Dadl, N33/IAP, OST4, STT3. The family also includes the SWP1 protein from yeast. In yeast the oligosaccharyltransferase complex is composed 7 or 8 subunits, SWP1, being one of them.


Pssm-ID: 461749  Cd Length: 624  Bit Score: 695.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130    9 VFLLALTIIASTWALTPTHYLTKHDVERLKASL--DRPFTNLESAFYSIVGLSSLGAQVPDAKkaCTYIRS---NLDPSN 83
Cdd:pfam05817   1 LLLLLLLLAATASALTVSSYLTDSDRSRLLSVFesGLPSSDLESAYYALSGLQLLGADVPDNQ--CKFLVKllaSSSLSD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130   84 VDSLFYAAQASQALsGCEISISNETKDLLLAAV-SEDSSVTQIYHAVAALSGFGLPLASQEALSALTARLSKEETVLArv 162
Cdd:pfam05817  79 LESLFYALSANKAL-KCSIKLPESVQSALKAALqKEDSSTSDLYYAVGSLKLLGLKIDAAKVVKALTALLKKDDSLES-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  163 wstvlesrslfskrTVQALQTASHLSQQADLRSIVEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEP 242
Cdd:pfam05817 156 --------------LGYALGIASQLDQGADLKFIFSRIEDAVVQADEVDGKYLQFEGGLSTTALVVRGIYKLADAVGKKP 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  243 SIKEDQVIQLMNAIFSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLSQPLTQATVK 322
Cdd:pfam05817 222 PITEDQAVKLANYFLSRKSVQTVKGAFNLLEALKTLSSNKFHIPVVVSLEGTALLSTKKPVLKVRVTNVLGKPLPPLTVK 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  323 LEHAKSVASRATVLQKTSFTPVGDVFELNFMNVKFSSGYYDFLVEV--EGDNRYIAN-TVELRVKISTEVGITNVDLSTV 399
Cdd:pfam05817 302 LESASSTSSDAVVLSKQELKPDATVYELDLLSLKPDRGIYTFDISAssAHDKRLAGNnSVTLKVKVTGEVKVENAEIGVA 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  400 DKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFEL 479
Cdd:pfam05817 382 DSDQSIAPKKQKVDYPSKLKKSLEADSHQKLRLSFALVDVNTGKPFTPHQAFVRLTHQKTKQEVIFVAEPDSSKAYKFDL 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  480 DTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEE--APSTVLSQNLFTPKQEIQ-------------- 543
Cdd:pfam05817 462 DLGGLAKDFGYLSGTYEVELIVGDATLENPILWNVGDVELKFPEEPekAPSPPDPKSLYGPKPEIKhlfrepekrpprvv 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  544 ------------------WIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMFQTLKYLAILGSVTFLAGNRML 605
Cdd:pfam05817 542 sdtftglvlapllillvlWLKLGVNLSNFPFSLSAILFHLGLGAILLLYVLFWLQLNMFTTLKYLALLGIFTFLAGNRLL 621

                  ...
gi 578836130  606 AQQ 608
Cdd:pfam05817 622 SHL 624
AF1543 COG1689
Class II terpene cyclase family protein AF1543 [General function prediction only];
17-151 2.64e-03

Class II terpene cyclase family protein AF1543 [General function prediction only];


Pssm-ID: 441295 [Multi-domain]  Cd Length: 272  Bit Score: 40.09  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  17 IASTWALTPTHYLTKHDVER-------LKASLDRP--FTNLESAFYSIVGLSSLGAQVPDAKKACTYIRSNL------DP 81
Cdd:COG1689   35 LADTYYAVRILKLLGEEVPNrdktiefLESCQDEEggGFALYTTSYGLMALALLGIDPPDEQEALEYLSDALptkfagGA 114
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578836130  82 SNVDSLFYAAQASQALSGCEISISNETKDLLLAAVSE------DSSVTQIYHAVAALSGFGLPLA-SQEALSALTAR 151
Cdd:COG1689  115 SDLEETYLAVALLEALGASEPEREKIREFLLSLRRPDggfggkKPNLEDTYWALAALRRLGRDLPpADRVIAFILAC 191
 
Name Accession Description Interval E-value
Ribophorin_II pfam05817
Oligosaccharyltransferase subunit Ribophorin II; This family contains eukaryotic Ribophorin II ...
9-608 0e+00

Oligosaccharyltransferase subunit Ribophorin II; This family contains eukaryotic Ribophorin II (RPN2) proteins. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylation of newly synthesized polypeptides, and is composed of the following proteins: ribophorins I and II (RI and RII), OST48, and Dadl, N33/IAP, OST4, STT3. The family also includes the SWP1 protein from yeast. In yeast the oligosaccharyltransferase complex is composed 7 or 8 subunits, SWP1, being one of them.


Pssm-ID: 461749  Cd Length: 624  Bit Score: 695.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130    9 VFLLALTIIASTWALTPTHYLTKHDVERLKASL--DRPFTNLESAFYSIVGLSSLGAQVPDAKkaCTYIRS---NLDPSN 83
Cdd:pfam05817   1 LLLLLLLLAATASALTVSSYLTDSDRSRLLSVFesGLPSSDLESAYYALSGLQLLGADVPDNQ--CKFLVKllaSSSLSD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130   84 VDSLFYAAQASQALsGCEISISNETKDLLLAAV-SEDSSVTQIYHAVAALSGFGLPLASQEALSALTARLSKEETVLArv 162
Cdd:pfam05817  79 LESLFYALSANKAL-KCSIKLPESVQSALKAALqKEDSSTSDLYYAVGSLKLLGLKIDAAKVVKALTALLKKDDSLES-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  163 wstvlesrslfskrTVQALQTASHLSQQADLRSIVEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEP 242
Cdd:pfam05817 156 --------------LGYALGIASQLDQGADLKFIFSRIEDAVVQADEVDGKYLQFEGGLSTTALVVRGIYKLADAVGKKP 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  243 SIKEDQVIQLMNAIFSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLSQPLTQATVK 322
Cdd:pfam05817 222 PITEDQAVKLANYFLSRKSVQTVKGAFNLLEALKTLSSNKFHIPVVVSLEGTALLSTKKPVLKVRVTNVLGKPLPPLTVK 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  323 LEHAKSVASRATVLQKTSFTPVGDVFELNFMNVKFSSGYYDFLVEV--EGDNRYIAN-TVELRVKISTEVGITNVDLSTV 399
Cdd:pfam05817 302 LESASSTSSDAVVLSKQELKPDATVYELDLLSLKPDRGIYTFDISAssAHDKRLAGNnSVTLKVKVTGEVKVENAEIGVA 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  400 DKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFEL 479
Cdd:pfam05817 382 DSDQSIAPKKQKVDYPSKLKKSLEADSHQKLRLSFALVDVNTGKPFTPHQAFVRLTHQKTKQEVIFVAEPDSSKAYKFDL 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  480 DTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEE--APSTVLSQNLFTPKQEIQ-------------- 543
Cdd:pfam05817 462 DLGGLAKDFGYLSGTYEVELIVGDATLENPILWNVGDVELKFPEEPekAPSPPDPKSLYGPKPEIKhlfrepekrpprvv 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  544 ------------------WIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMFQTLKYLAILGSVTFLAGNRML 605
Cdd:pfam05817 542 sdtftglvlapllillvlWLKLGVNLSNFPFSLSAILFHLGLGAILLLYVLFWLQLNMFTTLKYLALLGIFTFLAGNRLL 621

                  ...
gi 578836130  606 AQQ 608
Cdd:pfam05817 622 SHL 624
AF1543 COG1689
Class II terpene cyclase family protein AF1543 [General function prediction only];
17-151 2.64e-03

Class II terpene cyclase family protein AF1543 [General function prediction only];


Pssm-ID: 441295 [Multi-domain]  Cd Length: 272  Bit Score: 40.09  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836130  17 IASTWALTPTHYLTKHDVER-------LKASLDRP--FTNLESAFYSIVGLSSLGAQVPDAKKACTYIRSNL------DP 81
Cdd:COG1689   35 LADTYYAVRILKLLGEEVPNrdktiefLESCQDEEggGFALYTTSYGLMALALLGIDPPDEQEALEYLSDALptkfagGA 114
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578836130  82 SNVDSLFYAAQASQALSGCEISISNETKDLLLAAVSE------DSSVTQIYHAVAALSGFGLPLA-SQEALSALTAR 151
Cdd:COG1689  115 SDLEETYLAVALLEALGASEPEREKIREFLLSLRRPDggfggkKPNLEDTYWALAALRRLGRDLPpADRVIAFILAC 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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