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Conserved domains on  [gi|578837724|ref|XP_006724489|]
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lipase maturation factor 2 isoform X1 [Homo sapiens]

Protein Classification

lipase maturation factor family protein( domain architecture ID 10535984)

lipase maturation factor family protein similar to vertebrate lipase maturation factor, which is involved in the maturation of specific proteins in the endoplasmic reticulum, and may be required for maturation and transport of active lipoprotein lipase through the secretory pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 142-531 3.18e-159

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


:

Pssm-ID: 462004  Cd Length: 419  Bit Score: 464.12  E-value: 3.18e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  142 LAALTYHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFFNL 221
Cdd:pfam06762  67 LTALDYHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  222 MTLVLTTALLDDQHLAAEpghgSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHYFGLEVDWQQRtihsrttftfhq 301
Cdd:pfam06762 147 LTIVLSLSLLDDAFLYFW----TPESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKISENGT------------ 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  302 fsqWLKTLTLPTVWLGVASLVWELLSALWRWtqvrgwlRKLSAVVQLSLVGTATVALFLISLVPYSyvepgthgrLWTGA 381
Cdd:pfam06762 211 ---FLRRVTLPSIVLGLVSLLSVPVCALLRS-------NKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  382 HRLFGAVEHLQLANSYGLFRRMTglGGRPEVVLEGSYDGH-HWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQMWFAALGP 460
Cdd:pfam06762 272 SRMNASFNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGEgPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGT 349

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578837724  461 HTHSPWFTSLVLRLLQGKEPVIRLVQsqvaRYPFHKQPPTYVRAQRYKYWFSQPGE---QGQWWRRQWVEEFFP 531
Cdd:pfam06762 350 YQQNPWFLSLLYRLLQNDPEVLGLLD----HNPFPDKPPKYVRAELYRYRFTTPGErraTGAWWKRERVGEYFP 419
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
26-159 1.09e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  26 ALAAAVGDPDAAVGSAETGAGHGPGPGAAEPAGCTSGPGSPAAEPTAPPChlLAALGRLPVSLPGGPGVPlfPVGLPAAR 105
Cdd:PRK12323 362 AFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA--AAAAARAVAAAPARRSPA--PEALAAAR 437

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578837724 106 DWLPGRAGGPAEASLPPQGGPPGQAGRGPAPRRPPLLAALTYHYETQCLPTPAA 159
Cdd:PRK12323 438 QASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP 491
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 142-531 3.18e-159

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 464.12  E-value: 3.18e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  142 LAALTYHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFFNL 221
Cdd:pfam06762  67 LTALDYHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  222 MTLVLTTALLDDQHLAAEpghgSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHYFGLEVDWQQRtihsrttftfhq 301
Cdd:pfam06762 147 LTIVLSLSLLDDAFLYFW----TPESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKISENGT------------ 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  302 fsqWLKTLTLPTVWLGVASLVWELLSALWRWtqvrgwlRKLSAVVQLSLVGTATVALFLISLVPYSyvepgthgrLWTGA 381
Cdd:pfam06762 211 ---FLRRVTLPSIVLGLVSLLSVPVCALLRS-------NKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  382 HRLFGAVEHLQLANSYGLFRRMTglGGRPEVVLEGSYDGH-HWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQMWFAALGP 460
Cdd:pfam06762 272 SRMNASFNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGEgPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGT 349

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578837724  461 HTHSPWFTSLVLRLLQGKEPVIRLVQsqvaRYPFHKQPPTYVRAQRYKYWFSQPGE---QGQWWRRQWVEEFFP 531
Cdd:pfam06762 350 YQQNPWFLSLLYRLLQNDPEVLGLLD----HNPFPDKPPKYVRAELYRYRFTTPGErraTGAWWKRERVGEYFP 419
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
26-159 1.09e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  26 ALAAAVGDPDAAVGSAETGAGHGPGPGAAEPAGCTSGPGSPAAEPTAPPChlLAALGRLPVSLPGGPGVPlfPVGLPAAR 105
Cdd:PRK12323 362 AFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA--AAAAARAVAAAPARRSPA--PEALAAAR 437

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578837724 106 DWLPGRAGGPAEASLPPQGGPPGQAGRGPAPRRPPLLAALTYHYETQCLPTPAA 159
Cdd:PRK12323 438 QASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP 491
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 142-531 3.18e-159

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 464.12  E-value: 3.18e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  142 LAALTYHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFFNL 221
Cdd:pfam06762  67 LTALDYHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  222 MTLVLTTALLDDQHLAAEpghgSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHYFGLEVDWQQRtihsrttftfhq 301
Cdd:pfam06762 147 LTIVLSLSLLDDAFLYFW----TPESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKISENGT------------ 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  302 fsqWLKTLTLPTVWLGVASLVWELLSALWRWtqvrgwlRKLSAVVQLSLVGTATVALFLISLVPYSyvepgthgrLWTGA 381
Cdd:pfam06762 211 ---FLRRVTLPSIVLGLVSLLSVPVCALLRS-------NKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  382 HRLFGAVEHLQLANSYGLFRRMTglGGRPEVVLEGSYDGH-HWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQMWFAALGP 460
Cdd:pfam06762 272 SRMNASFNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGEgPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGT 349

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578837724  461 HTHSPWFTSLVLRLLQGKEPVIRLVQsqvaRYPFHKQPPTYVRAQRYKYWFSQPGE---QGQWWRRQWVEEFFP 531
Cdd:pfam06762 350 YQQNPWFLSLLYRLLQNDPEVLGLLD----HNPFPDKPPKYVRAELYRYRFTTPGErraTGAWWKRERVGEYFP 419
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
26-159 1.09e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724  26 ALAAAVGDPDAAVGSAETGAGHGPGPGAAEPAGCTSGPGSPAAEPTAPPChlLAALGRLPVSLPGGPGVPlfPVGLPAAR 105
Cdd:PRK12323 362 AFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA--AAAAARAVAAAPARRSPA--PEALAAAR 437

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578837724 106 DWLPGRAGGPAEASLPPQGGPPGQAGRGPAPRRPPLLAALTYHYETQCLPTPAA 159
Cdd:PRK12323 438 QASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP 491
PHA03247 PHA03247
large tegument protein UL36; Provisional
 56-158 5.11e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837724   56 PAGCTSGPGSPAA-EPTAPPCHLLAALGR---LPVSLPGGPGVPLFPVGLPAArdwlPGRAGGPAEASLPPQGG--PPGQ 129
Cdd:PHA03247 2786 PAVASLSESRESLpSPWDPADPPAAVLAPaaaLPPAASPAGPLPPPTSAQPTA----PPPPPGPPPPSLPLGGSvaPGGD 2861

                          90       100
                  ....*....|....*....|....*....
gi 578837724  130 AGRGPAPRRPPLLAALTYHYETQCLPTPA 158
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPARPPVRRLARPA 2890
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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