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Conserved domains on  [gi|688559967|ref|XP_009300617|]
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BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X1 [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 15337384)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to vertebrate BUB3-interacting and GLEBS motif-containing protein ZNF207

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
10-90 9.61e-64

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 200.48  E-value: 9.61e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  10 KPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKDTIDGVPNAIPGRTDIELEIYGMEGIPEKD 89
Cdd:cd20908    1 KPWCYYCDREFDDEKILIQHQKAKHFKCHICHKKLYTAGGLAVHCLQVHKETLTKVPNALPGRDDPEIEIFGMEGIPEGD 80

                 .
gi 688559967  90 I 90
Cdd:cd20908   81 I 81
PHA03247 super family cl33720
large tegument protein UL36; Provisional
226-465 1.67e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  226 PSMAPAAPVTvPGLASRPAVPITQSAASKPLFPSAVQMGTgvanPSALPASAEIQSASSKPLFPNSAQAQQTVSGPSSTS 305
Cdd:PHA03247 2741 PPAVPAGPAT-PGGPARPARPPTTAGPPAPAPPAAPAAGP----PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  306 SDSPKVTFPAYTQPPSTSSVvPASSSTVAKPPATVTS-------------KPATLTTLSATSKLMHPDEDISLEERRAQL 372
Cdd:PHA03247 2816 AALPPAASPAGPLPPPTSAQ-PTAPPPPPGPPPPSLPlggsvapggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRS 2894
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  373 PRYQRLIPRPGQTAATAASAPPSGAVGGMMPPQQPGMRHPIHGQYGGPPQAMSGFMAVGMP----PYGQNAPMVPSYQAG 448
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPsgavPQPWLGALVPGRVAV 2974
                         250
                  ....*....|....*..
gi 688559967  449 PVGPPMGIRPSVMSPGS 465
Cdd:PHA03247 2975 PRFRVPQPAPSREAPAS 2991
 
Name Accession Description Interval E-value
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
10-90 9.61e-64

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 200.48  E-value: 9.61e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  10 KPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKDTIDGVPNAIPGRTDIELEIYGMEGIPEKD 89
Cdd:cd20908    1 KPWCYYCDREFDDEKILIQHQKAKHFKCHICHKKLYTAGGLAVHCLQVHKETLTKVPNALPGRDDPEIEIFGMEGIPEGD 80

                 .
gi 688559967  90 I 90
Cdd:cd20908   81 I 81
PHA03247 PHA03247
large tegument protein UL36; Provisional
226-465 1.67e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  226 PSMAPAAPVTvPGLASRPAVPITQSAASKPLFPSAVQMGTgvanPSALPASAEIQSASSKPLFPNSAQAQQTVSGPSSTS 305
Cdd:PHA03247 2741 PPAVPAGPAT-PGGPARPARPPTTAGPPAPAPPAAPAAGP----PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  306 SDSPKVTFPAYTQPPSTSSVvPASSSTVAKPPATVTS-------------KPATLTTLSATSKLMHPDEDISLEERRAQL 372
Cdd:PHA03247 2816 AALPPAASPAGPLPPPTSAQ-PTAPPPPPGPPPPSLPlggsvapggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRS 2894
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  373 PRYQRLIPRPGQTAATAASAPPSGAVGGMMPPQQPGMRHPIHGQYGGPPQAMSGFMAVGMP----PYGQNAPMVPSYQAG 448
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPsgavPQPWLGALVPGRVAV 2974
                         250
                  ....*....|....*..
gi 688559967  449 PVGPPMGIRPSVMSPGS 465
Cdd:PHA03247 2975 PRFRVPQPAPSREAPAS 2991
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
223-354 3.51e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  223 PGMPSMAPAAPVTVPGLASRPAVP--ITQSAASKPLF---------PSAVQMGTGVANPSALPASAEIQSASSKPLFPNS 291
Cdd:pfam05109 432 PTLNTTGFAAPNTTTGLPSSTHVPtnLTAPASTGPTVstadvtsptPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTS 511
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688559967  292 AQAQQT---VSGPSSTSSDSPKVTFPAYTQPPSTSSVVPASSSTVAKPPATVTSKP-ATLTTLSATS 354
Cdd:pfam05109 512 AVTTPTpnaTSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPnATIPTLGKTS 578
 
Name Accession Description Interval E-value
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
10-90 9.61e-64

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 200.48  E-value: 9.61e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  10 KPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKDTIDGVPNAIPGRTDIELEIYGMEGIPEKD 89
Cdd:cd20908    1 KPWCYYCDREFDDEKILIQHQKAKHFKCHICHKKLYTAGGLAVHCLQVHKETLTKVPNALPGRDDPEIEIFGMEGIPEGD 80

                 .
gi 688559967  90 I 90
Cdd:cd20908   81 I 81
PHA03247 PHA03247
large tegument protein UL36; Provisional
226-465 1.67e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  226 PSMAPAAPVTvPGLASRPAVPITQSAASKPLFPSAVQMGTgvanPSALPASAEIQSASSKPLFPNSAQAQQTVSGPSSTS 305
Cdd:PHA03247 2741 PPAVPAGPAT-PGGPARPARPPTTAGPPAPAPPAAPAAGP----PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  306 SDSPKVTFPAYTQPPSTSSVvPASSSTVAKPPATVTS-------------KPATLTTLSATSKLMHPDEDISLEERRAQL 372
Cdd:PHA03247 2816 AALPPAASPAGPLPPPTSAQ-PTAPPPPPGPPPPSLPlggsvapggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRS 2894
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  373 PRYQRLIPRPGQTAATAASAPPSGAVGGMMPPQQPGMRHPIHGQYGGPPQAMSGFMAVGMP----PYGQNAPMVPSYQAG 448
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPsgavPQPWLGALVPGRVAV 2974
                         250
                  ....*....|....*..
gi 688559967  449 PVGPPMGIRPSVMSPGS 465
Cdd:PHA03247 2975 PRFRVPQPAPSREAPAS 2991
motB PRK12799
flagellar motor protein MotB; Reviewed
235-355 1.70e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 40.47  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967 235 TVPGLASRPAVPITQSAA---SKPLFPSAVQMGTGVANPSALPASAEIQSASSKPLFPNSAQAQQTVSGPSSTSSdspKV 311
Cdd:PRK12799 298 TVPVAAVTPSSAVTQSSAitpSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPAAEPV---NM 374
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 688559967 312 TFPAYTQPPSTSSVVPASSSTVAKPPATVTSKPATLTTLSATSK 355
Cdd:PRK12799 375 QPQPMSTTETQQSSTGNITSTANGPTTSLPAAPASNIPVSPTSR 418
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
223-354 3.51e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  223 PGMPSMAPAAPVTVPGLASRPAVP--ITQSAASKPLF---------PSAVQMGTGVANPSALPASAEIQSASSKPLFPNS 291
Cdd:pfam05109 432 PTLNTTGFAAPNTTTGLPSSTHVPtnLTAPASTGPTVstadvtsptPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTS 511
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688559967  292 AQAQQT---VSGPSSTSSDSPKVTFPAYTQPPSTSSVVPASSSTVAKPPATVTSKP-ATLTTLSATS 354
Cdd:pfam05109 512 AVTTPTpnaTSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPnATIPTLGKTS 578
PHA03247 PHA03247
large tegument protein UL36; Provisional
223-459 8.77e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 8.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  223 PGMPSMAPAAPVTVPGLASRPAVPITQSAASKPLFPSAVQMGTGVANPSALPASAEIQSASSKPLFPNSAQAQQTVSGPS 302
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  303 STSSDSPKVTFPAYTQPPSTSSVVPASSSTVAKPPATVTSKPATLTTLSATSKLMHPDEDISLE---------ERRA--- 370
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvRRRPpsr 2869
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688559967  371 ---------QLPRYQRLiPRPGQTAATAASAPPSgavGGMMPPQQPGMRHPIHGQYGGPPQAMSgfmAVGMPPYGQ-NAP 440
Cdd:PHA03247 2870 spaakpaapARPPVRRL-ARPAVSRSTESFALPP---DQPERPPQPQAPPPPQPQPQPPPPPQP---QPPPPPPPRpQPP 2942
                         250
                  ....*....|....*....
gi 688559967  441 MVPSYQAGPVGPPMGIRPS 459
Cdd:PHA03247 2943 LAPTTDPAGAGEPSGAVPQ 2961
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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