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Conserved domains on  [gi|741976975|ref|XP_010818485|]
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leucine-rich repeat-containing protein 27 isoform X3 [Bos taurus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-143 5.93e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 5.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  42 ILDLSQSGLHHFGE-IFKVPNLKQLHLQRNALCTIPKDFFQLlPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIR 120
Cdd:COG4886  140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|...
gi 741976975 121 MLPVELGSVTTLKALSLRHCPLE 143
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLT 241
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 273-628 8.15e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 8.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  273 PAELPPSLRAALSSRGKPLPRPRPlcRMKIPSFQGVLPELDSTRQAlVRTSQLGKSRGlalqelrERQAQEQSKSAHVLL 352
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRPAP--RPSEPAVTSRARRPDAPPQS-ARPRAPVDDRG-------DPRGPAPPSPLPPDT 2621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  353 PAPRHPPQRQAIAARvegEYPGDEEKAGGAREPASPAPAEePAVTSRRKQRPPARPPCPGLRRQHPCSPAARLPRSSLWA 432
Cdd:PHA03247 2622 HAPDPPPPSPSPAAN---EPDPHPPPTVPPPERPRDDPAP-GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS 2697

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  433 L--------RPLPRSSSLT-CLQLRPGSSQRGSHSSAASSGGLCRPgnPPPASSFPGPVRAVLAPHPTRSLPRAIPRPGR 503
Cdd:PHA03247 2698 LadppppppTPEPAPHALVsATPLPPGPAAARQASPALPAAPAPPA--VPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  504 SSVVLPKQLCPGVQASSPALLRA---------ALCLQLRTPVCETPVMKSLCPCPGPQGPPTAHALCPGPSPP------- 567
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLpspwdpadpPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPslplggs 2855

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 741976975  568 ----GVSSERGWGWSPYPSTCTGSRLQAaagQTVRAPCPSRPPGPAMQDALACCPSGVPWLPLLP 628
Cdd:PHA03247 2856 vapgGDVRRRPPSRSPAAKPAAPARPPV---RRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-143 5.93e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 5.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  42 ILDLSQSGLHHFGE-IFKVPNLKQLHLQRNALCTIPKDFFQLlPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIR 120
Cdd:COG4886  140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|...
gi 741976975 121 MLPVELGSVTTLKALSLRHCPLE 143
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLT 241
LRR_8 pfam13855
Leucine rich repeat;
60-119 8.81e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 8.81e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741976975   60 PNLKQLHLQRNALCTIPKDFFQLLPNLSWLDLRFNRITAL-PSGIGCHKHLKTLLLERNPI 119
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PHA03247 PHA03247
large tegument protein UL36; Provisional
 273-628 8.15e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 8.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  273 PAELPPSLRAALSSRGKPLPRPRPlcRMKIPSFQGVLPELDSTRQAlVRTSQLGKSRGlalqelrERQAQEQSKSAHVLL 352
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRPAP--RPSEPAVTSRARRPDAPPQS-ARPRAPVDDRG-------DPRGPAPPSPLPPDT 2621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  353 PAPRHPPQRQAIAARvegEYPGDEEKAGGAREPASPAPAEePAVTSRRKQRPPARPPCPGLRRQHPCSPAARLPRSSLWA 432
Cdd:PHA03247 2622 HAPDPPPPSPSPAAN---EPDPHPPPTVPPPERPRDDPAP-GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS 2697

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  433 L--------RPLPRSSSLT-CLQLRPGSSQRGSHSSAASSGGLCRPgnPPPASSFPGPVRAVLAPHPTRSLPRAIPRPGR 503
Cdd:PHA03247 2698 LadppppppTPEPAPHALVsATPLPPGPAAARQASPALPAAPAPPA--VPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  504 SSVVLPKQLCPGVQASSPALLRA---------ALCLQLRTPVCETPVMKSLCPCPGPQGPPTAHALCPGPSPP------- 567
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLpspwdpadpPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPslplggs 2855

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 741976975  568 ----GVSSERGWGWSPYPSTCTGSRLQAaagQTVRAPCPSRPPGPAMQDALACCPSGVPWLPLLP 628
Cdd:PHA03247 2856 vapgGDVRRRPPSRSPAAKPAAPARPPV---RRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-116 2.30e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.30e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 741976975  60 PNLKQLHLQRNALCTIpkDFFQLLPNLSWLDLRFNRITALpSGIGCHKHLKTLLLER 116
Cdd:cd21340   46 TNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-137 2.08e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  38 SSSAILDLSQSGLHHFGEI----FKVPNLKQLHLQRNALC-TIPKDFFQLLPNLSWLDLRFNRIT-ALPSG-IGChkhLK 110
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKIssaiFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGsIPN---LE 143

                         90       100
                 ....*....|....*....|....*...
gi 741976975 111 TLLLERNPIR-MLPVELGSVTTLKALSL 137
Cdd:PLN00113 144 TLDLSNNMLSgEIPNDIGSFSSLKVLDL 171
LRR smart00370
Leucine-rich repeats, outliers;
83-103 2.55e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.55e-03
                           10        20
                   ....*....|....*....|.
gi 741976975    83 LPNLSWLDLRFNRITALPSGI 103
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGA 21
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-143 5.93e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 5.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  42 ILDLSQSGLHHFGE-IFKVPNLKQLHLQRNALCTIPKDFFQLlPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIR 120
Cdd:COG4886  140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|...
gi 741976975 121 MLPVELGSVTTLKALSLRHCPLE 143
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-148 3.96e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 3.96e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  50 LHHFGEIFKVPNLKQLHLQRNALCTIPKDFFQLlPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIRMLPVELGSV 129
Cdd:COG4886  103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNL 181

                         90       100
                 ....*....|....*....|
gi 741976975 130 TTLKALSLRHCPL-EFPPPL 148
Cdd:COG4886  182 TNLKELDLSNNQItDLPEPL 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-148 1.81e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  43 LDLSQSGLHHFG-EIFKVPNLKQLHLQRNALCTIPKDFFQLlPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIRM 121
Cdd:COG4886  164 LDLSNNQLTDLPeELGNLTNLKELDLSNNQITDLPEPLGNL-TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTD 242

                         90       100
                 ....*....|....*....|....*..
gi 741976975 122 LPvELGSVTTLKALSLRHCPLEFPPPL 148
Cdd:COG4886  243 LP-ELGNLTNLEELDLSNNQLTDLPPL 268
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-143 4.35e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  43 LDLSQSGLHHFG-EIFKVPNLKQLHLQRNALCTIPKDFFQLlPNLSWLDLRFNRITALPSgIGCHKHLKTLLLERNPIRM 121
Cdd:COG4886  187 LDLSNNQITDLPePLGNLTNLEELDLSGNQLTDLPEPLANL-TNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTD 264

                         90       100
                 ....*....|....*....|..
gi 741976975 122 LPvELGSVTTLKALSLRHCPLE 143
Cdd:COG4886  265 LP-PLANLTNLKTLDLSNNQLT 285
LRR_8 pfam13855
Leucine rich repeat;
60-119 8.81e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 8.81e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741976975   60 PNLKQLHLQRNALCTIPKDFFQLLPNLSWLDLRFNRITAL-PSGIGCHKHLKTLLLERNPI 119
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-99 2.16e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 2.16e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 741976975  42 ILDLSQSGLHHFGEIFKVPNLKQLHLQRNALCTIPKDFFqlLPNLSWLDLRFNRITAL 99
Cdd:COG4886  232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDL 287
PHA03247 PHA03247
large tegument protein UL36; Provisional
 273-628 8.15e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 8.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  273 PAELPPSLRAALSSRGKPLPRPRPlcRMKIPSFQGVLPELDSTRQAlVRTSQLGKSRGlalqelrERQAQEQSKSAHVLL 352
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRPAP--RPSEPAVTSRARRPDAPPQS-ARPRAPVDDRG-------DPRGPAPPSPLPPDT 2621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  353 PAPRHPPQRQAIAARvegEYPGDEEKAGGAREPASPAPAEePAVTSRRKQRPPARPPCPGLRRQHPCSPAARLPRSSLWA 432
Cdd:PHA03247 2622 HAPDPPPPSPSPAAN---EPDPHPPPTVPPPERPRDDPAP-GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS 2697

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  433 L--------RPLPRSSSLT-CLQLRPGSSQRGSHSSAASSGGLCRPgnPPPASSFPGPVRAVLAPHPTRSLPRAIPRPGR 503
Cdd:PHA03247 2698 LadppppppTPEPAPHALVsATPLPPGPAAARQASPALPAAPAPPA--VPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  504 SSVVLPKQLCPGVQASSPALLRA---------ALCLQLRTPVCETPVMKSLCPCPGPQGPPTAHALCPGPSPP------- 567
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLpspwdpadpPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPslplggs 2855

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 741976975  568 ----GVSSERGWGWSPYPSTCTGSRLQAaagQTVRAPCPSRPPGPAMQDALACCPSGVPWLPLLP 628
Cdd:PHA03247 2856 vapgGDVRRRPPSRSPAAKPAAPARPPV---RRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-116 2.30e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.30e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 741976975  60 PNLKQLHLQRNALCTIpkDFFQLLPNLSWLDLRFNRITALpSGIGCHKHLKTLLLER 116
Cdd:cd21340   46 TNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-122 2.43e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  43 LDLSQSGLHHFGEIFKVPNLKQLHLQRNALCTIPKdfFQLLPNLSWLDLRFNRITALPsGIGCHKHLKTLLLERNPIRML 122
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
338-505 3.11e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975 338 ERQAQEQSKSAHVLLPAPRHPPQRQAIAARVEGEYPGDEEKAGGAREPAS-PAPAEEPAVTSRRKQRPPARPPCPGLRRQ 416
Cdd:PRK12323 397 PAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGaPAPAPAPAAAPAAAARPAAAGPRPVAAAA 476

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975 417 HPCSPAARLPRSSLWALRPLPRSSSLTCLQLRPGSSQRGSHSSAASSGGLCRPGNPPPASSF----PGPVRAVLAPHPTR 492
Cdd:PRK12323 477 AAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFetlaPAPAAAPAPRAAAA 556

                        170
                 ....*....|...
gi 741976975 493 SLPRAIPRPGRSS 505
Cdd:PRK12323 557 TEPVVAPRPPRAS 569
PHA03378 PHA03378
EBNA-3B; Provisional
 218-528 4.91e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 4.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975 218 ADFFPPVetldPHEPRRSTEPPEDWPSEEEIRRFWKLRQEIVENEQAGALG-NQLLPAELPPSLRAALSS-----RGKPL 291
Cdd:PHA03378 522 ATLLPPS----PPQPRAGRRAPCVYTEDLDIESDEPASTEPVHDQLLPAPGlGPLQIQPLTSPTTSQLASsapsyAQTPW 597

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975 292 PRPRPLCRMKIPSFQGVLPELDSTRQALVrtsqlgKSRGLALQELRERQAQEQsksaHVLLPAPRHPPQRQAIAARVE-- 369
Cdd:PHA03378 598 PVPHPSQTPEPPTTQSHIPETSAPRQWPM------PLRPIPMRPLRMQPITFN----VLVFPTPHQPPQVEITPYKPTwt 667

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975 370 --GEYPGDEEKAGGA---REPASPAPAEEPAVTSRRkQRPPARPPCPGLRRQHPCSPAARLPRSSLWALRPLPRSSSLTC 444
Cdd:PHA03378 668 qiGHIPYQPSPTGANtmlPIQWAPGTMQPPPRAPTP-MRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARP 746

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975 445 LQLRPGSSQRGSHSSAASSGGLCRPGNPPPASSFPGPVRAVLAPHPTRSlPRAIPRPGRSSVVLPKQLCPGVQASSPALL 524
Cdd:PHA03378 747 PAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPT-PQPPPQAGPTSMQLMPRAAPGQQGPTKQIL 825


                 ....
gi 741976975 525 RAAL 528
Cdd:PHA03378 826 RQLL 829
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-137 2.08e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975  38 SSSAILDLSQSGLHHFGEI----FKVPNLKQLHLQRNALC-TIPKDFFQLLPNLSWLDLRFNRIT-ALPSG-IGChkhLK 110
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKIssaiFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGsIPN---LE 143

                         90       100
                 ....*....|....*....|....*...
gi 741976975 111 TLLLERNPIR-MLPVELGSVTTLKALSL 137
Cdd:PLN00113 144 TLDLSNNMLSgEIPNDIGSFSSLKVLDL 171
LRR smart00370
Leucine-rich repeats, outliers;
83-103 2.55e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.55e-03
                           10        20
                   ....*....|....*....|.
gi 741976975    83 LPNLSWLDLRFNRITALPSGI 103
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGA 21
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
83-103 2.55e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.55e-03
                           10        20
                   ....*....|....*....|.
gi 741976975    83 LPNLSWLDLRFNRITALPSGI 103
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGA 21
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 84-118 7.46e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 7.46e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 741976975   84 PNLSWLDLRFNRITALPSGIGChKHLKTLLLERNP 118
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKL-PNLETLDLSGNN 34
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 338-705 9.65e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.20  E-value: 9.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975 338 ERQAQEQSKSAHVLLPAPRHPPQRQAIAARVEGEYPGDEEKAGGAREPASPAPAEEPAVTSRRKQRPPARPPCPGLRRQH 417
Cdd:PRK07764 379 ERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPP 458

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975 418 PCSPAArlprsslwalRPLPRSSSLTCLQLRPGSSQRGSHSSAASSGGLCRPGNPPPASSFPGPVRA---VLAPHPTRS- 493
Cdd:PRK07764 459 AAAPSA----------QPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERwpeILAAVPKRSr 528

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975 494 ------LPRAIPRPGRSSVVLPKQLCPG-----VQASSPALLRAALCLQLR---TPVCETPVMKSLCPCPGPQGPPTAHA 559
Cdd:PRK07764 529 ktwailLPEATVLGVRGDTLVLGFSTGGlarrfASPGNAEVLVTALAEELGgdwQVEAVVGPAPGAAGGEGPPAPASSGP 608

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976975 560 LCPGPSPPGVSSERGWGWSPYPSTCTGSRLQAAAGQTVRAPCPSRPPGPAMQDALACCPSGVPWLPLLPSAGSRPAwvli 639
Cdd:PRK07764 609 PEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPA---- 684

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 741976975 640 wqrkgPRSWAQGPQAGLRSAVQATGHETGSRPPPLPQGPGGPFPSTCTPCPLAPRSLFMVMRAPPP 705
Cdd:PRK07764 685 -----PAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEP 745
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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