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Conserved domains on  [gi|755507872|ref|XP_011238761|]
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low-density lipoprotein receptor-related protein 8 isoform X6 [Mus musculus]

Protein Classification

LY and Ldl_recept_b domain-containing protein( domain architecture ID 10819330)

protein containing domains LDLa, FXa_inhibition, LY, and Ldl_recept_b

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 545-585 2.87e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.87e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755507872  545 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 585
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 483-524 1.14e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.00  E-value: 1.14e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 755507872   483 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 524
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 41-75 2.89e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.89e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 755507872  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 569-611 6.38e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 6.38e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755507872   569 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 611
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 79-111 6.29e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 6.29e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872    79 TCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 292-326 1.57e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 1.57e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 755507872 292 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 326
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 256-286 3.21e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.21e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 755507872 256 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 286
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 200-232 3.09e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 3.09e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872   200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDE 232
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 632-672 3.21e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 3.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755507872  632 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 672
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 333-367 2.61e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 2.61e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 755507872  333 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 367
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 121-157 1.17e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 1.17e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 755507872 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:cd00112    1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
369-399 2.06e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872   369 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 399
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 438-473 9.94e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 9.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 755507872   438 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 473
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 690-727 2.06e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.45  E-value: 2.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 755507872  690 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 727
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 545-585 2.87e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.87e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755507872  545 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 585
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 483-524 1.14e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.00  E-value: 1.14e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 755507872   483 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 524
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 41-75 2.89e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.89e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 755507872  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 569-611 6.38e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 6.38e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755507872   569 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 611
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 526-568 2.51e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 2.51e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755507872   526 TLFSRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKAGLNGADR 568
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 40-72 4.51e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 4.51e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872    40 ECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDE 72
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 503-542 5.42e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.24  E-value: 5.42e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755507872  503 HIYWTDSGNK-TISVATTDGRRRCTLFSRELSEPRAIAVDP 542
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 79-111 6.29e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 6.29e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872    79 TCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 292-326 1.57e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 1.57e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 755507872 292 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 326
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 256-286 3.21e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.21e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 755507872 256 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 286
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
256-286 3.51e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 3.51e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755507872  256 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 286
Cdd:pfam00057   7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 80-111 3.54e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.54e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 755507872  80 CADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
291-326 7.02e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.25  E-value: 7.02e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 755507872  291 PCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 326
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
41-75 1.52e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 1.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 755507872   41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 292-323 3.03e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 3.03e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 755507872   292 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDE 323
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 200-232 3.09e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 3.09e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872   200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDE 232
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 632-672 3.21e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 3.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755507872  632 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 672
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 486-670 3.82e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 3.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 486 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCT-----LFSRELSEPRAIAVDPlRGFMYWSDWG------F 554
Cdd:cd05819   51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGnhriqkF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 555 QAK---IEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGNrkMLIFSTDF-----LSHPFG 626
Cdd:cd05819  129 DPDgefLTTFGSGGSGPGQFNG-----PTGVAVD-SDGNIYVADTGNHRIQVFDPDGNF--LTTFGSTGtgpgqFNYPTG 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755507872 627 VAVFED-KVFWTDLENEAIFSANRLNGLEIAI-----LAENLNNPHDIVI 670
Cdd:cd05819  201 IAVDSDgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 200-233 4.09e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 4.09e-08
                         10        20        30
                 ....*....|....*....|....*....|....
gi 755507872 200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDEA 233
Cdd:cd00112    1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 256-283 9.51e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.78  E-value: 9.51e-08
                           10        20
                   ....*....|....*....|....*...
gi 755507872   256 QFTCRSGECIHLGWRCDGDRDCKDKSDE 283
Cdd:smart00192   6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
78-111 1.31e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 1.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 755507872   78 RTCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 589-631 1.71e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.71e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755507872  589 QRLYWVDSKLHQ-LSSIDFNGGNRKMLIfsTDFLSHPFGVAVFE 631
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 333-367 2.61e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 2.61e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 755507872  333 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 367
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 121-157 1.17e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 1.17e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 755507872 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:cd00112    1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
200-233 3.14e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 3.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 755507872  200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDEA 233
Cdd:pfam00057   3 CSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEE 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
501-652 1.00e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 501 HKHIYWTDSGNKTISV-ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKagLNGADRQTLvsDNI--- 576
Cdd:COG3391   79 GRRLYVANSGSGRVSViDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSG-NGRVSV--IDTATGKVV--ATIpvg 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 577 EWPNGITLDLLSQRLYWVDSKLHQLSSI--DFNGGNRKmLIFSTDFLSHPFGVAVFED--KVFWTDLENEaifSANRLNG 652
Cdd:COG3391  152 AGPHGIAVDPDGKRLYVANSGSNTVSVIvsVIDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGGSN 227
EGF_CA smart00179
Calcium-binding EGF-like domain;
369-399 2.06e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872   369 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 399
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 120-154 5.62e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.08  E-value: 5.62e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 755507872   120 ECPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 154
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
121-157 6.27e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 6.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 755507872  121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 369-402 6.85e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 6.85e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 755507872 369 DIDECQDPDACS--QICVNYKGYFKCECHPGYEMDT 402
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGRN 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 438-473 9.94e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 9.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 755507872   438 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 473
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 690-727 2.06e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.45  E-value: 2.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 755507872  690 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 727
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 545-585 2.87e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.87e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755507872  545 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 585
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 483-524 1.14e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.00  E-value: 1.14e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 755507872   483 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 524
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 41-75 2.89e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.89e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 755507872  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 569-611 6.38e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 6.38e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755507872   569 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 611
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 526-568 2.51e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 2.51e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755507872   526 TLFSRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKAGLNGADR 568
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 40-72 4.51e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 4.51e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872    40 ECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDE 72
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 503-542 5.42e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.24  E-value: 5.42e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755507872  503 HIYWTDSGNK-TISVATTDGRRRCTLFSRELSEPRAIAVDP 542
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 79-111 6.29e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 6.29e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872    79 TCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 292-326 1.57e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 1.57e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 755507872 292 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 326
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 256-286 3.21e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.21e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 755507872 256 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 286
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
256-286 3.51e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 3.51e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755507872  256 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 286
Cdd:pfam00057   7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 80-111 3.54e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.54e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 755507872  80 CADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
291-326 7.02e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.25  E-value: 7.02e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 755507872  291 PCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 326
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
41-75 1.52e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 1.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 755507872   41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 292-323 3.03e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 3.03e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 755507872   292 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDE 323
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 200-232 3.09e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 3.09e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872   200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDE 232
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 632-672 3.21e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 3.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755507872  632 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 672
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 486-670 3.82e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 3.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 486 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCT-----LFSRELSEPRAIAVDPlRGFMYWSDWG------F 554
Cdd:cd05819   51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGnhriqkF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 555 QAK---IEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGNrkMLIFSTDF-----LSHPFG 626
Cdd:cd05819  129 DPDgefLTTFGSGGSGPGQFNG-----PTGVAVD-SDGNIYVADTGNHRIQVFDPDGNF--LTTFGSTGtgpgqFNYPTG 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755507872 627 VAVFED-KVFWTDLENEAIFSANRLNGLEIAI-----LAENLNNPHDIVI 670
Cdd:cd05819  201 IAVDSDgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 200-233 4.09e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 4.09e-08
                         10        20        30
                 ....*....|....*....|....*....|....
gi 755507872 200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDEA 233
Cdd:cd00112    1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 486-670 4.84e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.40  E-value: 4.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 486 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMY-----------W 549
Cdd:cd05819    4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFGSFgsgdgQFNEPAGVAVDS-DGNLYvadtgnhriqkF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 550 SDWGfqAKIEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGnrkmLIF-------STDFLS 622
Cdd:cd05819   82 DPDG--NFLASFGGSGDGDGEFNG-----PRGIAVD-SSGNIYVADTGNHRIQKFDPDGE----FLTtfgsggsGPGQFN 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755507872 623 HPFGVAVF-EDKVFWTDLENEAI--FSAnrlNGLEIAILAEN------LNNPHDIVI 670
Cdd:cd05819  150 GPTGVAVDsDGNIYVADTGNHRIqvFDP---DGNFLTTFGSTgtgpgqFNYPTGIAV 203
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 256-283 9.51e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.78  E-value: 9.51e-08
                           10        20
                   ....*....|....*....|....*...
gi 755507872   256 QFTCRSGECIHLGWRCDGDRDCKDKSDE 283
Cdd:smart00192   6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
78-111 1.31e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 1.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 755507872   78 RTCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 589-631 1.71e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.71e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755507872  589 QRLYWVDSKLHQ-LSSIDFNGGNRKMLIfsTDFLSHPFGVAVFE 631
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 333-367 2.61e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 2.61e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 755507872  333 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 367
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 121-157 1.17e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 1.17e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 755507872 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:cd00112    1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
200-233 3.14e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 3.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 755507872  200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDEA 233
Cdd:pfam00057   3 CSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEE 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
501-652 1.00e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 501 HKHIYWTDSGNKTISV-ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKagLNGADRQTLvsDNI--- 576
Cdd:COG3391   79 GRRLYVANSGSGRVSViDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSG-NGRVSV--IDTATGKVV--ATIpvg 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 577 EWPNGITLDLLSQRLYWVDSKLHQLSSI--DFNGGNRKmLIFSTDFLSHPFGVAVFED--KVFWTDLENEaifSANRLNG 652
Cdd:COG3391  152 AGPHGIAVDPDGKRLYVANSGSNTVSVIvsVIDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGGSN 227
EGF_CA smart00179
Calcium-binding EGF-like domain;
369-399 2.06e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755507872   369 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 399
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 486-638 2.25e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 47.31  E-value: 2.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 486 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRcTLF------SRELSEPRAIAVDPlRGFMYWSDWG------ 553
Cdd:cd05819   98 DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFL-TTFgsggsgPGQFNGPTGVAVDS-DGNIYVADTGnhriqv 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 554 ------FQAKIEKAGLNGADRQTlvsdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNG------GNRkmlIFSTDFL 621
Cdd:cd05819  175 fdpdgnFLTTFGSTGTGPGQFNY--------PTGIAVD-SDGNIYVADSGNNRVQVFDPDGagfggnGNF---LGSDGQF 242

                        170
                 ....*....|....*...
gi 755507872 622 SHPFGVAVFED-KVFWTD 638
Cdd:cd05819  243 NRPSGLAVDSDgNLYVAD 260
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 120-154 5.62e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.08  E-value: 5.62e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 755507872   120 ECPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 154
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
121-157 6.27e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 6.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 755507872  121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 369-402 6.85e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 6.85e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 755507872 369 DIDECQDPDACS--QICVNYKGYFKCECHPGYEMDT 402
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGRN 36
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 488-644 8.65e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 45.35  E-value: 8.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 488 QLHSPEGLAVDWVHkHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPLrGFMYWSD-WGFqaKIEKA 561
Cdd:cd14956   11 QFKDPRGIAVDADD-NVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVDKD-GWLYVADyWGD--RIQVF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 562 GLNGADRQTL-VSDNIE----WPNGITLDllSQRLYWVdsklhqlssIDFngGNRKMLIFSTD--FLS------------ 622
Cdd:cd14956   87 TLTGELQTIGgSSGSGPgqfnAPRGVAVD--ADGNLYV---------ADF--GNQRIQKFDPDgsFLRqwggtgiepgsf 153

                        170       180
                 ....*....|....*....|....
gi 755507872 623 -HPFGVAVFEDKVFW-TDLENEAI 644
Cdd:cd14956  154 nYPRGVAVDPDGTLYvADTYNDRI 177
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 438-473 9.94e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 9.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 755507872   438 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 473
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 453-629 1.43e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.50  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 453 ATNRIYWCDLSYRKIYSAHMDkasipDEQVVLIDEQLHSPEGLAVD-----WVhkhiywTDSGNKTISVATTDGRRR--C 525
Cdd:COG3386   17 PDGRLYWVDIPGGRIHRYDPD-----GGAVEVFAEPSGRPNGLAFDpdgrlLV------ADHGRGLVRFDPADGEVTvlA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 526 TLFSRELSEPRAIAVDPlRGFMYWSDwgFQAKIEKAGL---NGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 602
Cdd:COG3386   86 DEYGKPLNRPNDGVVDP-DGRLYFTD--MGEYLPTGALyrvDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIY 162

                        170       180       190
                 ....*....|....*....|....*....|.
gi 755507872 603 SIDFNG----GNRKMLIFSTDFLSHPFGVAV 629
Cdd:COG3386  163 RFDLDAdgtlGNRRVFADLPDGPGGPDGLAV 193
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 486-673 3.18e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 43.43  E-value: 3.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 486 DEQLHSPEGLAVDWvhKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMYWSDWGFQaKIEK 560
Cdd:cd14963    6 GDPLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPgtgpgEFKYPYGIAVDS-DGNIYVADLYNG-RIQV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 561 AGLNGADRQTLVSD----NIEWPNGITLDllSQRLYWVDSKLHQLSSIDFNGgnRKMLIFST--DF---LSHPFGVAVFE 631
Cdd:cd14963   82 FDPDGKFLKYFPEKkdrvKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG--KLLLEFGKpgSEpgeLSYPNGIAVDE 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755507872 632 DK-VFWTDLENEAI--FSAN-----RLNGLEIAilAENLNNP------------------HDIVIFHE 673
Cdd:cd14963  158 DGnIYVADSGNGRIqvFDKNgkfikELNGSPDG--KSGFVNPrgiavdpdgnlyvvdnlsHRVYVFDE 223
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 409-599 5.62e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.96  E-value: 5.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 409 AVAGKSPSLIF---TNRHEVRRIDLVKRDYSRLIP----MLKNVVALDVEVAtNRIYWCDLSYRKIYsaHMDkasiPDEQ 481
Cdd:cd14962   16 GVAADGRGRIYvadTGRGAVFVFDLPNGKVFVIGNagpnRFVSPIGVAIDAN-GNLYVSDAELGKVF--VFD----RDGK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 482 VV-LIDE--QLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMYWSDwG 553
Cdd:cd14962   89 FLrAIGAgaLFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRgsgpgEFNLPTDLAVDR-DGNLYVTD-T 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755507872 554 FQAKIEKAGLNGADRQT-----LVSDNIEWPNGITLDlLSQRLYWVDSKLH 599
Cdd:cd14962  167 MNFRVQIFDADGKFLRSfgergDGPGSFARPKGIAVD-SEGNIYVVDAAFD 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 455-499 9.43e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 9.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 755507872  455 NRIYWCDLSYR-KIYSAHMDKASipdeQVVLIDEQLHSPEGLAVDW 499
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSD----RKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
420-553 1.46e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755507872 420 TNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYsahmdKASIPDEQVVLIDEQLHSPEGLAVDW 499
Cdd:COG3391   87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVS-----VIDTATGKVVATIPVGAGPHGIAVDP 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755507872 500 VHKHIYWTDSGNKTISV-----ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWG 553
Cdd:COG3391  162 DGKRLYVANSGSNTVSVivsviDTATGKVVATI--PVGGGPVGVAVSPDGRRLYVANRG 218
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 690-727 2.06e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.45  E-value: 2.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 755507872  690 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 727
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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