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Conserved domains on  [gi|755525407|ref|XP_011240490|]
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fibrinogen-like protein 1 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FReD super family cl00085
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 80-199 4.08e-59

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


The actual alignment was detected with superfamily member cd00087:

Pssm-ID: 412152 [Multi-domain]  Cd Length: 215  Bit Score: 185.14  E-value: 4.08e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525407  80 KQYADCSEIYNDGFKQSGFYKIKPLQSLAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFvqnNGEYWL 158
Cdd:cd00087    1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMdTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNL---DGEFWL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 755525407 159 GNKNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKK 199
Cdd:cd00087   78 GLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSES 118
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 80-199 4.08e-59

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 185.14  E-value: 4.08e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525407  80 KQYADCSEIYNDGFKQSGFYKIKPLQSLAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFvqnNGEYWL 158
Cdd:cd00087    1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMdTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNL---DGEFWL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 755525407 159 GNKNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKK 199
Cdd:cd00087   78 GLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSES 118
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 81-199 4.16e-57

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 179.78  E-value: 4.16e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525407    81 QYADCSEIYNDGFKQSGFYKIKPLQSLAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFvqnNGEYWLG 159
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMeTDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNL---AGEFWLG 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 755525407   160 NKNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKK 199
Cdd:smart00186  78 NENIHLLTSQGKYELRIDLEDWEGNTAYALYDSFKVADEA 117
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
82-199 1.44e-43

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 145.74  E-value: 1.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525407   82 YADCSEIYNDGFKQSGFYKIKPLQSLAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFvqNNGEYWLGN 160
Cdd:pfam00147   2 GRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMeTDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNL--SPGEFWLGN 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 755525407  161 KNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKK 199
Cdd:pfam00147  80 DKIHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVTNEN 118
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 85-125 2.49e-10

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 54.11  E-value: 2.49e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 755525407  85 CSEIYNDGF-KQSGFYKIKP--LQSLAEFSVYCDM-SDGGGWTVI 125
Cdd:NF040941   2 CWEILQAGPsAPSGVYWIDPdgMGGLAPFQVYCDMtTDGGGWTLV 46
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 80-199 4.08e-59

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 185.14  E-value: 4.08e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525407  80 KQYADCSEIYNDGFKQSGFYKIKPLQSLAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFvqnNGEYWL 158
Cdd:cd00087    1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMdTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNL---DGEFWL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 755525407 159 GNKNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKK 199
Cdd:cd00087   78 GLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSES 118
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 81-199 4.16e-57

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 179.78  E-value: 4.16e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525407    81 QYADCSEIYNDGFKQSGFYKIKPLQSLAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFvqnNGEYWLG 159
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMeTDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNL---AGEFWLG 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 755525407   160 NKNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKK 199
Cdd:smart00186  78 NENIHLLTSQGKYELRIDLEDWEGNTAYALYDSFKVADEA 117
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
82-199 1.44e-43

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 145.74  E-value: 1.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755525407   82 YADCSEIYNDGFKQSGFYKIKPLQSLAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFvqNNGEYWLGN 160
Cdd:pfam00147   2 GRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMeTDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNL--SPGEFWLGN 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 755525407  161 KNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKK 199
Cdd:pfam00147  80 DKIHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVTNEN 118
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 85-125 2.49e-10

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 54.11  E-value: 2.49e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 755525407  85 CSEIYNDGF-KQSGFYKIKP--LQSLAEFSVYCDM-SDGGGWTVI 125
Cdd:NF040941   2 CWEILQAGPsAPSGVYWIDPdgMGGLAPFQVYCDMtTDGGGWTLV 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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