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Conserved domains on  [gi|755528845|ref|XP_011240841|]
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evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X2 [Mus musculus]

Protein Classification

ECSIT and ECSIT_C domain-containing protein( domain architecture ID 12069161)

ECSIT and ECSIT_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECSIT pfam06239
Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a ...
 73-266 3.95e-116

Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1.


:

Pssm-ID: 461857  Cd Length: 191  Bit Score: 335.09  E-value: 3.95e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528845   73 EDSFKPSGnrERDKASFLNAVRSFGAHNVRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIFV 152
Cdd:pfam06239   1 EDLFSAAG--KRKKASFLMVVIFFKQRSVRRRGHVDFIYAALKKMPEFGVERDLAVYNLLLDVFPKEVFRPRNFIQRFFH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528845  153 HYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLR 232
Cdd:pfam06239  79 HYPRQQECGVAVLEQMENYGVMPNKETEFLLVQIFGRKSHPMRKYRRMMYWFPKFKNSNPFPVPPVLPDDPVDLAKLGLR 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 755528845  233 HMEPDLSAKVTVYQMSLPSDSTGmEDPTQPHIVG 266
Cdd:pfam06239 159 RMEPDLSARVTVYQMPVPSDIDD-EDPTQPHIVG 191
ECSIT_C super family cl20706
C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the ...
 269-350 7.20e-23

C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain


The actual alignment was detected with superfamily member pfam14784:

Pssm-ID: 464316  Cd Length: 131  Bit Score: 92.76  E-value: 7.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528845  269 SPDQQAALARHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEEKVE---EIPEEWELYYPQKLDLEYSRSGWDDY- 344
Cdd:pfam14784   1 SPEQQELLAKHPPNEPVFVEGPFPVWLRDKCVYYFVLRADPKLIPPEEFEdedDVSNERIPYFPWFLDWDKDRDEAKKEl 80


                  ....*...
gi 755528845  345 --EFDVDE 350
Cdd:pfam14784  81 vvKFSVHE 88
 
Name Accession Description Interval E-value
ECSIT pfam06239
Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a ...
 73-266 3.95e-116

Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1.


Pssm-ID: 461857  Cd Length: 191  Bit Score: 335.09  E-value: 3.95e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528845   73 EDSFKPSGnrERDKASFLNAVRSFGAHNVRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIFV 152
Cdd:pfam06239   1 EDLFSAAG--KRKKASFLMVVIFFKQRSVRRRGHVDFIYAALKKMPEFGVERDLAVYNLLLDVFPKEVFRPRNFIQRFFH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528845  153 HYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLR 232
Cdd:pfam06239  79 HYPRQQECGVAVLEQMENYGVMPNKETEFLLVQIFGRKSHPMRKYRRMMYWFPKFKNSNPFPVPPVLPDDPVDLAKLGLR 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 755528845  233 HMEPDLSAKVTVYQMSLPSDSTGmEDPTQPHIVG 266
Cdd:pfam06239 159 RMEPDLSARVTVYQMPVPSDIDD-EDPTQPHIVG 191
ECSIT_C pfam14784
C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the ...
 269-350 7.20e-23

C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain


Pssm-ID: 464316  Cd Length: 131  Bit Score: 92.76  E-value: 7.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528845  269 SPDQQAALARHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEEKVE---EIPEEWELYYPQKLDLEYSRSGWDDY- 344
Cdd:pfam14784   1 SPEQQELLAKHPPNEPVFVEGPFPVWLRDKCVYYFVLRADPKLIPPEEFEdedDVSNERIPYFPWFLDWDKDRDEAKKEl 80


                  ....*...
gi 755528845  345 --EFDVDE 350
Cdd:pfam14784  81 vvKFSVHE 88
 
Name Accession Description Interval E-value
ECSIT pfam06239
Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a ...
 73-266 3.95e-116

Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1.


Pssm-ID: 461857  Cd Length: 191  Bit Score: 335.09  E-value: 3.95e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528845   73 EDSFKPSGnrERDKASFLNAVRSFGAHNVRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIFV 152
Cdd:pfam06239   1 EDLFSAAG--KRKKASFLMVVIFFKQRSVRRRGHVDFIYAALKKMPEFGVERDLAVYNLLLDVFPKEVFRPRNFIQRFFH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528845  153 HYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLR 232
Cdd:pfam06239  79 HYPRQQECGVAVLEQMENYGVMPNKETEFLLVQIFGRKSHPMRKYRRMMYWFPKFKNSNPFPVPPVLPDDPVDLAKLGLR 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 755528845  233 HMEPDLSAKVTVYQMSLPSDSTGmEDPTQPHIVG 266
Cdd:pfam06239 159 RMEPDLSARVTVYQMPVPSDIDD-EDPTQPHIVG 191
ECSIT_C pfam14784
C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the ...
 269-350 7.20e-23

C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain


Pssm-ID: 464316  Cd Length: 131  Bit Score: 92.76  E-value: 7.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528845  269 SPDQQAALARHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEEKVE---EIPEEWELYYPQKLDLEYSRSGWDDY- 344
Cdd:pfam14784   1 SPEQQELLAKHPPNEPVFVEGPFPVWLRDKCVYYFVLRADPKLIPPEEFEdedDVSNERIPYFPWFLDWDKDRDEAKKEl 80


                  ....*...
gi 755528845  345 --EFDVDE 350
Cdd:pfam14784  81 vvKFSVHE 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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