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Conserved domains on  [gi|755534532|ref|XP_011241747|]
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GAS2-like protein 3 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
46-174 2.10e-89

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409118  Cd Length: 130  Bit Score: 274.41  E-value: 2.10e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  46 EATLLPMQEDLSIWLSGLLGVDIKAERLLEELDNGVLLCQLINVLQNMVKGCHS-DEPGNFPMRKVPCKKDAASGSFFAR 124
Cdd:cd21269    1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVLQSKIKECCStEELKHFPMRKVPCKKDAPSGSFFAR 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 755534532 125 DNTANFLHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYG 174
Cdd:cd21269   81 DNTANFLSWCRAIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
215-283 4.43e-30

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


:

Pssm-ID: 460480  Cd Length: 69  Bit Score: 112.69  E-value: 4.43e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755534532  215 LHEAVKHIAEDppCSCSHRFSIEYLSEGRYRLGE--KILFIRMLHgKHVMVRVGGGWDTLQGFLLKYDPCR 283
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRILR-SHVMVRVGGGWDTLEEYLLKHDPCR 68
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
335-682 1.15e-08

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 58.39  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  335 PGTPVSVPKNKEKQVRLPgarlpassvkgNLASPSTRAKRPDSPASFPHPKVTSLKDAAKKTTAPSNSVSQSLASPNP-G 413
Cdd:pfam05109 487 PVTPSPSPRDNGTESKAP-----------DMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPnA 555
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  414 SKPSTAQCASESSRKCVTFPKTAQTKAI--PAQNSrdlsksrllPSKSPGKMEPKHLKHNHLSSRDESRINLSSKSPKLP 491
Cdd:pfam05109 556 TSPTPAVTTPTPNATIPTLGKTSPTSAVttPTPNA---------TSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNAT 626
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  492 KGAMHGRPNPSpfqppakvtkpSSKTGAIGLGTQSQPPTRTPRSGAVSAqrlqSTLNLNSPASVCSGSS-AKATQGSKGK 570
Cdd:pfam05109 627 SAVTTGQHNIT-----------SSSTSSMSLRPSSISETLSPSTSDNST----SHMPLLTSAHPTGGENiTQVTPASTST 691
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  571 NTVSVAKKQPQSKGVCRNPGPGSSKS---PGRTPLSIVTVPQSATKTETVSkSAKTAMKGQYSAKGPPKSS---KPPTSF 644
Cdd:pfam05109 692 HHVSTSSPAPRPGTTSQASGPGNSSTstkPGEVNVTKGTPPKNATSPQAPS-GQKTAVPTVTSTGGKANSTtggKHTTGH 770
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 755534532  645 RDPPSSGKGADSGDKMPTARKKEEDDHYFVMTGNKKLR 682
Cdd:pfam05109 771 GARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSKLR 808
 
Name Accession Description Interval E-value
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
46-174 2.10e-89

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 274.41  E-value: 2.10e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  46 EATLLPMQEDLSIWLSGLLGVDIKAERLLEELDNGVLLCQLINVLQNMVKGCHS-DEPGNFPMRKVPCKKDAASGSFFAR 124
Cdd:cd21269    1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVLQSKIKECCStEELKHFPMRKVPCKKDAPSGSFFAR 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 755534532 125 DNTANFLHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYG 174
Cdd:cd21269   81 DNTANFLSWCRAIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
215-283 4.43e-30

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 112.69  E-value: 4.43e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755534532  215 LHEAVKHIAEDppCSCSHRFSIEYLSEGRYRLGE--KILFIRMLHgKHVMVRVGGGWDTLQGFLLKYDPCR 283
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRILR-SHVMVRVGGGWDTLEEYLLKHDPCR 68
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
213-286 2.11e-27

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 105.61  E-value: 2.11e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755534532   213 EELHEAVKHIAEDppCSCSHRFSIEYLSEGRYRLG-EKILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRILQ 286
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGdSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
54-163 1.02e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 56.17  E-value: 1.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532    54 EDLSIWLSGLLG--VDIKAERLLEELDNGVLLCQLINVLQnmvkgchsdePGNFPMRKVpckkDAASGSFFARDNTANFL 131
Cdd:smart00033   1 KTLLRWVNSLLAeyDKPPVTNFSSDLKDGVALCALLNSLS----------PGLVDKKKV----AASLSRFKKIENINLAL 66
                           90       100       110
                   ....*....|....*....|....*....|...
gi 755534532   132 HWCRHIGVDETyLFESEGLVL-HKDPRQVYLCL 163
Cdd:smart00033  67 SFAEKLGGKVV-LFEPEDLVEgPKLILGVIWTL 98
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
50-168 1.22e-09

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 56.14  E-value: 1.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532   50 LPMQEDLSIWLSGLLGVDIKAER---LLEELDNGVLLCQLINVLQnmvkgchsdePGNFPMRKVPCKKdaasgsFFARDN 126
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRvtnFTTDLRDGLALCALLNKLA----------PGLVDKKKLNKSE------FDKLEN 64
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 755534532  127 TANFLHWCR-HIGVDEtYLFESEGLVlHKDPRQVYLCLLEIGR 168
Cdd:pfam00307  65 INLALDVAEkKLGVPK-VLIEPEDLV-EGDNKSVLTYLASLFR 105
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
335-682 1.15e-08

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 58.39  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  335 PGTPVSVPKNKEKQVRLPgarlpassvkgNLASPSTRAKRPDSPASFPHPKVTSLKDAAKKTTAPSNSVSQSLASPNP-G 413
Cdd:pfam05109 487 PVTPSPSPRDNGTESKAP-----------DMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPnA 555
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  414 SKPSTAQCASESSRKCVTFPKTAQTKAI--PAQNSrdlsksrllPSKSPGKMEPKHLKHNHLSSRDESRINLSSKSPKLP 491
Cdd:pfam05109 556 TSPTPAVTTPTPNATIPTLGKTSPTSAVttPTPNA---------TSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNAT 626
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  492 KGAMHGRPNPSpfqppakvtkpSSKTGAIGLGTQSQPPTRTPRSGAVSAqrlqSTLNLNSPASVCSGSS-AKATQGSKGK 570
Cdd:pfam05109 627 SAVTTGQHNIT-----------SSSTSSMSLRPSSISETLSPSTSDNST----SHMPLLTSAHPTGGENiTQVTPASTST 691
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  571 NTVSVAKKQPQSKGVCRNPGPGSSKS---PGRTPLSIVTVPQSATKTETVSkSAKTAMKGQYSAKGPPKSS---KPPTSF 644
Cdd:pfam05109 692 HHVSTSSPAPRPGTTSQASGPGNSSTstkPGEVNVTKGTPPKNATSPQAPS-GQKTAVPTVTSTGGKANSTtggKHTTGH 770
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 755534532  645 RDPPSSGKGADSGDKMPTARKKEEDDHYFVMTGNKKLR 682
Cdd:pfam05109 771 GARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSKLR 808
PHA03247 PHA03247
large tegument protein UL36; Provisional
307-661 3.21e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  307 PDSPARTPQP-----PEMNPLSAVNMFQKQNLRPGTPVSVPKNKEKQVRLPGARLPASSVKGNLASPS----TRAKRPDS 377
Cdd:PHA03247 2624 PDPPPPSPSPaanepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvgslTSLADPPP 2703
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  378 PASFPHPKVTSLKDAAKKTTAPSNSVSQSLASP-NPGSKPSTAQCASESSRKCVTFPKTAQTKAIPAqnsrdlsksrllP 456
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA------------P 2771
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  457 SKSPGKMEPKHLKHNHLSSRDESRINLSSKspklpkgamhgrPNPSPFQPPAKVTKPSSKTGAIGLGTQSQPPTRTPRSG 536
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSP------------WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  537 AVSAQRLQSTLNLNspASVCSGSSAKATQGSKGKNTVSVAKKQPQSKGVCRNPGPGSSKSPGRTPLSIVTVPQSATKTET 616
Cdd:PHA03247 2840 PPPPGPPPPSLPLG--GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 755534532  617 VSKSAKTAMKGQYSAKGPPKSSKPPTSFRDPPSSGKGADSGDKMP 661
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
SCP1 COG5199
Calponin [Cytoskeleton];
53-168 2.14e-06

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 48.38  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  53 QEDLSIWLSGLLGVDIKAE-RLLEELDNGVLLCQLIN-VLQNMVKGCHSDEPgnfpmrkvpckkdaasgsFFARDNTANF 130
Cdd:COG5199   15 QKEVTLWIETVLGEKFEPPgDLLSLLKDGVRLCRILNeASPLDIKYKESKMP------------------FVQMENISSF 76
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 755534532 131 LHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGR 168
Cdd:COG5199   77 INGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSR 114
 
Name Accession Description Interval E-value
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
46-174 2.10e-89

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 274.41  E-value: 2.10e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  46 EATLLPMQEDLSIWLSGLLGVDIKAERLLEELDNGVLLCQLINVLQNMVKGCHS-DEPGNFPMRKVPCKKDAASGSFFAR 124
Cdd:cd21269    1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVLQSKIKECCStEELKHFPMRKVPCKKDAPSGSFFAR 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 755534532 125 DNTANFLHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYG 174
Cdd:cd21269   81 DNTANFLSWCRAIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
45-177 9.06e-65

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 210.18  E-value: 9.06e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  45 HEATLLPMQEDLSIWLSGLLGVDIKAERLLEELDNGVLLCQLINVLQNMVKGCHSD--EPG-NFPMRKVPCKKDAASGSF 121
Cdd:cd21267    1 HEASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQEKFKENSADanKPGkSLPVRKIPCRANAPSGSF 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755534532 122 FARDNTANFLHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGVEP 177
Cdd:cd21267   81 FARDNTANFLSWCRDVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGVEP 136
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
46-174 1.89e-60

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 198.65  E-value: 1.89e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  46 EATLLPMQEDLSIWLSGLLGVDIKAERLLEELDNGVLLCQLINVLQNMVKGCHSDEPGNFP--MRKVPCKKDAASGSFFA 123
Cdd:cd21204    1 EEALLPMKEDLAEWLNDLLGDDLTPDNFLDELRNGVVLCQLAQKIQEAAEKAREAGKKNGPppSYKLKCNENAKPGSFFA 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755534532 124 RDNTANFLHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYG 174
Cdd:cd21204   81 RDNVANFLRWCRKLGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
46-175 2.89e-35

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 130.13  E-value: 2.89e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  46 EATLLPMQEDLSIWLSGLLGVDIKAERLLEELDNGVLLCQLINVLQNMV---KGCHSDEP---GNFPMRKVPCKKDAASG 119
Cdd:cd21268    6 EEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAArefQAQHPERAsplKLPPREVIFYRPSAKPG 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755534532 120 SFFARDNTANFLHWCRH-IGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGV 175
Cdd:cd21268   86 SFQARDNVSNFINWCRQlLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
215-283 4.43e-30

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 112.69  E-value: 4.43e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755534532  215 LHEAVKHIAEDppCSCSHRFSIEYLSEGRYRLGE--KILFIRMLHgKHVMVRVGGGWDTLQGFLLKYDPCR 283
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRILR-SHVMVRVGGGWDTLEEYLLKHDPCR 68
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
213-286 2.11e-27

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 105.61  E-value: 2.11e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755534532   213 EELHEAVKHIAEDppCSCSHRFSIEYLSEGRYRLG-EKILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRILQ 286
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGdSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
53-168 1.65e-18

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 81.23  E-value: 1.65e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  53 QEDLSIWLSGLLGVDI--KAERLLEELDNGVLLCQLINVLQNmvkgchsdepgnfpmRKVPCKKDAASGSFFARDNTANF 130
Cdd:cd00014    1 EEELLKWINEVLGEELpvSITDLFESLRDGVLLCKLINKLSP---------------GSIPKINKKPKSPFKKRENINLF 65
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 755534532 131 LHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGR 168
Cdd:cd00014   66 LNACKKLGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
59-168 5.33e-12

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 62.71  E-value: 5.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  59 WLSGLLGVDIKAERLLEE-LDNGVLLCQLINVLQnmvkgchsdePGNFPmrkvpcKKDAASGSFFARDNTANFLHWCRHI 137
Cdd:cd21207   13 WIEAVTGEKLDDGKDYEDvLKDGVILCKLINILK----------PGSVK------KINTSKMAFKLMENIENFLTACKGY 76
                         90       100       110
                 ....*....|....*....|....*....|.
gi 755534532 138 GVDETYLFESEGLVLHKDPRQVYLCLLEIGR 168
Cdd:cd21207   77 GVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
52-168 3.53e-10

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 57.38  E-value: 3.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  52 MQEDLSIWLSGLLGVDIKAERLLEELDNGVLLCQLIN-VLQNMVKgchsdepgnfpmrkvpcKKDAASGSFFARDNTANF 130
Cdd:cd21210    1 AEQEAREWIEEVLGEKLAQGDLLDALKDGVVLCKLANrILPADIR-----------------KYKESKMPFVQMENISAF 63
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 755534532 131 LHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGR 168
Cdd:cd21210   64 LNAARKLGVPENDLFQTVDLFERKNPAQVLQCLHALSR 101
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
54-163 1.02e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 56.17  E-value: 1.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532    54 EDLSIWLSGLLG--VDIKAERLLEELDNGVLLCQLINVLQnmvkgchsdePGNFPMRKVpckkDAASGSFFARDNTANFL 131
Cdd:smart00033   1 KTLLRWVNSLLAeyDKPPVTNFSSDLKDGVALCALLNSLS----------PGLVDKKKV----AASLSRFKKIENINLAL 66
                           90       100       110
                   ....*....|....*....|....*....|...
gi 755534532   132 HWCRHIGVDETyLFESEGLVL-HKDPRQVYLCL 163
Cdd:smart00033  67 SFAEKLGGKVV-LFEPEDLVEgPKLILGVIWTL 98
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
50-168 1.22e-09

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 56.14  E-value: 1.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532   50 LPMQEDLSIWLSGLLGVDIKAER---LLEELDNGVLLCQLINVLQnmvkgchsdePGNFPMRKVPCKKdaasgsFFARDN 126
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRvtnFTTDLRDGLALCALLNKLA----------PGLVDKKKLNKSE------FDKLEN 64
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 755534532  127 TANFLHWCR-HIGVDEtYLFESEGLVlHKDPRQVYLCLLEIGR 168
Cdd:pfam00307  65 INLALDVAEkKLGVPK-VLIEPEDLV-EGDNKSVLTYLASLFR 105
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
335-682 1.15e-08

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 58.39  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  335 PGTPVSVPKNKEKQVRLPgarlpassvkgNLASPSTRAKRPDSPASFPHPKVTSLKDAAKKTTAPSNSVSQSLASPNP-G 413
Cdd:pfam05109 487 PVTPSPSPRDNGTESKAP-----------DMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPnA 555
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  414 SKPSTAQCASESSRKCVTFPKTAQTKAI--PAQNSrdlsksrllPSKSPGKMEPKHLKHNHLSSRDESRINLSSKSPKLP 491
Cdd:pfam05109 556 TSPTPAVTTPTPNATIPTLGKTSPTSAVttPTPNA---------TSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNAT 626
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  492 KGAMHGRPNPSpfqppakvtkpSSKTGAIGLGTQSQPPTRTPRSGAVSAqrlqSTLNLNSPASVCSGSS-AKATQGSKGK 570
Cdd:pfam05109 627 SAVTTGQHNIT-----------SSSTSSMSLRPSSISETLSPSTSDNST----SHMPLLTSAHPTGGENiTQVTPASTST 691
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  571 NTVSVAKKQPQSKGVCRNPGPGSSKS---PGRTPLSIVTVPQSATKTETVSkSAKTAMKGQYSAKGPPKSS---KPPTSF 644
Cdd:pfam05109 692 HHVSTSSPAPRPGTTSQASGPGNSSTstkPGEVNVTKGTPPKNATSPQAPS-GQKTAVPTVTSTGGKANSTtggKHTTGH 770
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 755534532  645 RDPPSSGKGADSGDKMPTARKKEEDDHYFVMTGNKKLR 682
Cdd:pfam05109 771 GARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSKLR 808
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
58-163 1.00e-07

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 50.69  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  58 IWLSGLLGVDIKAER-LLEELDNGVLLCQLINVLQnmvkgchsdepgnfPmRKVPCKKDAASG-SFFARDNTANFLHWCR 135
Cdd:cd21206   15 QWIEACLNEELPPTTeFEEELRNGVVLAKLANKFA--------------P-KLVPLKKIYDVGlQFRHTDNINHFLRALK 79
                         90       100
                 ....*....|....*....|....*...
gi 755534532 136 HIGVDETYLFESEGLVLHKDPRQVYLCL 163
Cdd:cd21206   80 KIGLPKIFHFETTDLYEKKNIPKVIYCL 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
307-661 3.21e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  307 PDSPARTPQP-----PEMNPLSAVNMFQKQNLRPGTPVSVPKNKEKQVRLPGARLPASSVKGNLASPS----TRAKRPDS 377
Cdd:PHA03247 2624 PDPPPPSPSPaanepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvgslTSLADPPP 2703
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  378 PASFPHPKVTSLKDAAKKTTAPSNSVSQSLASP-NPGSKPSTAQCASESSRKCVTFPKTAQTKAIPAqnsrdlsksrllP 456
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA------------P 2771
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  457 SKSPGKMEPKHLKHNHLSSRDESRINLSSKspklpkgamhgrPNPSPFQPPAKVTKPSSKTGAIGLGTQSQPPTRTPRSG 536
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSP------------WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  537 AVSAQRLQSTLNLNspASVCSGSSAKATQGSKGKNTVSVAKKQPQSKGVCRNPGPGSSKSPGRTPLSIVTVPQSATKTET 616
Cdd:PHA03247 2840 PPPPGPPPPSLPLG--GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 755534532  617 VSKSAKTAMKGQYSAKGPPKSSKPPTSFRDPPSSGKGADSGDKMP 661
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
59-170 4.96e-07

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 48.87  E-value: 4.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  59 WLSGLLGVDIKAERLLEELDNGVLLCQLINVLQnmvkgchsdePGNfpMRKVPCKKDAASGsffaRDNTANFLHWCRHIG 138
Cdd:cd21208    8 WIEAVTGKKFPSDDFRESLEDGILLCELINAIK----------PGS--IKKINRLPTPIAG----LDNLNLFLKACEDLG 71
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755534532 139 VDETYLFES-----------EGLVLHKDP----RQVYLCLLEIGRIV 170
Cdd:cd21208   72 LKDSQLFDPtdlqdlsnrriATHVRKKEDerrlKNVAITLYWLGRAA 118
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
70-166 8.65e-07

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 48.07  E-value: 8.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  70 AERLLEELDNGVLLCQLINVLQ-NMVKGCHSDEPGnfpmrkVPcKKDAASgsffARDNTANFLHWCRHIGVDETYLFESE 148
Cdd:cd21205   19 PDDLGEALMDGVVLCHLANHVRpRSVPSIHVPSPA------VP-KLSMAK----CRRNVENFLEACRKLGVPEERLCSPG 87
                         90
                 ....*....|....*...
gi 755534532 149 GLVLHKDPRQVYLCLLEI 166
Cdd:cd21205   88 DILEEKGLVRVAVTVQAL 105
CH_CNN1 cd21282
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ...
53-164 9.39e-07

calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409131 [Multi-domain]  Cd Length: 108  Bit Score: 47.95  E-value: 9.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  53 QEDLSIWLSGLLGVDIkAERLLEELDNGVLLCQLINVLQnmvkgchsdePGNFPmrkvpcKKDAASGSFFARDNTANFLH 132
Cdd:cd21282    5 EEELRVWIEGVTGRRI-GDNFMDGLKDGVILCELINKLQ----------PGSVR------KINESTQNWHKLENIGNFIK 67
                         90       100       110
                 ....*....|....*....|....*....|..
gi 755534532 133 WCRHIGVDETYLFESEGLVLHKDPRQVYLCLL 164
Cdd:cd21282   68 AIMHYGVKPHDIFEANDLFENTNHTQVQSTLI 99
SCP1 COG5199
Calponin [Cytoskeleton];
53-168 2.14e-06

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 48.38  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  53 QEDLSIWLSGLLGVDIKAE-RLLEELDNGVLLCQLIN-VLQNMVKGCHSDEPgnfpmrkvpckkdaasgsFFARDNTANF 130
Cdd:COG5199   15 QKEVTLWIETVLGEKFEPPgDLLSLLKDGVRLCRILNeASPLDIKYKESKMP------------------FVQMENISSF 76
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 755534532 131 LHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGR 168
Cdd:COG5199   77 INGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSR 114
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
310-664 4.68e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 4.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  310 PARTPQPPEMNPLSAVNMFQKQNLRPGTPVSVPKNKEKQVRLPGARLPASSVKGNLASPST-------------RAKRPD 376
Cdd:PHA03307   61 ACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPppaspppspapdlSEMLRP 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  377 SPASFPHPKVTSLKDAAKKTTAPSNSVSQSLASPNPGSKPSTAQCASESSRKCVTFPKTAQTKAIPAQNSRDLSKSRLLP 456
Cdd:PHA03307  141 VGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSP 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  457 SKSPGKMepkhlkhnhlsSRDESRINLSSKSPKLPKGAMHGRPNPSPFQPPAKVTKPSS-KTGAIGLGTQSQPPTRTPRS 535
Cdd:PHA03307  221 APAPGRS-----------AADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRiWEASGWNGPSSRPGPASSSS 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  536 GAVSAQRlqstlnlnSPASVCSGSSAKATQGSKGKNTVSV----------AKKQPQSKGVCRNPGPGSSKSPGRTPLSIV 605
Cdd:PHA03307  290 SPRERSP--------SPSPSSPGSGPAPSSPRASSSSSSSressssstssSSESSRGAAVSPGPSPSRSPSPSRPPPPAD 361
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755534532  606 TVPQS-------ATKTETVSKSAKTAMKGQYSAKGPPKSSKPPTSF--RDPPSSGKGADSGDKMPTAR 664
Cdd:PHA03307  362 PSSPRkrprpsrAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFpaGRPRPSPLDAGAASGAFYAR 429
CH_AtKIN14-like cd21203
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ...
59-132 1.23e-05

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409052 [Multi-domain]  Cd Length: 112  Bit Score: 44.71  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  59 WLSGLLGVDIKA----ERLLEELDNGVLLCQLINVLQnmvkgchsdePGNFPMR-KVPCKKDAASGSFFAR-DNTANFLH 132
Cdd:cd21203    8 WIQNVLGVLVLPdpseEEFRLCLRDGVVLCKLLNKLQ----------PGAVPKVvESPDDPDGAAGSAFQYfENVRNFLV 77
CH_CNN cd21211
calponin homology (CH) domain found in the calponin family; Calponin is an actin ...
53-166 9.57e-05

calponin homology (CH) domain found in the calponin family; Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of non-muscle cells. There are three calponin isoforms, calponin-1, -2, -3. All of them are actin-binding proteins with functions in inhibiting actin-activated myosin ATPase and stabilizing the actin cytoskeleton. Calponin-1 is specifically expressed in smooth muscle cells and plays a role in fine-tuning smooth muscle contractility. Calponin-2 is expressed in both smooth muscle and non-muscle cells and regulates multiple actin cytoskeleton-based functions. Calponin-3 is expressed in the brain and participates in actin cytoskeleton-based activities in embryonic development and myogenesis. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409060 [Multi-domain]  Cd Length: 108  Bit Score: 42.30  E-value: 9.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  53 QEDLSIWLSGLLGVDIkAERLLEELDNGVLLCQLINVLQnmvkgchsdePGNFPmrkvpcKKDAASGSFFARDNTANFLH 132
Cdd:cd21211    5 EAELRTWIEGVTGLSI-GPNFQKGLKDGIILCELINKLQ----------PGSVK------KINESMQNWHQLENIGNFIK 67
                         90       100       110
                 ....*....|....*....|....*....|....
gi 755534532 133 WCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEI 166
Cdd:cd21211   68 AIVSYGMKPHDIFEANDLFENGNMTQVQVTLLAL 101
PHA03378 PHA03378
EBNA-3B; Provisional
302-654 1.20e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532 302 SNESVPDS--PARTPQPPEMNPLSAVNMFQKQNLRPG-TPVSVPKNKEKQVRLPgarlpassvkgnlasPSTRAKRPDS- 377
Cdd:PHA03378 555 STEPVHDQllPAPGLGPLQIQPLTSPTTSQLASSAPSyAQTPWPVPHPSQTPEP---------------PTTQSHIPETs 619
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532 378 -PASFPHPKVTSLKDAAKKTTAPSNSvsqsLASPNPGSKPSTAQCASEssrkcvtfPKTAQTKAIPAQNSRDLSKSRLLP 456
Cdd:PHA03378 620 aPRQWPMPLRPIPMRPLRMQPITFNV----LVFPTPHQPPQVEITPYK--------PTWTQIGHIPYQPSPTGANTMLPI 687
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532 457 SKSPGKMEPKhlkhnhlssrdeSRINLSSKSPKLPKGAMHgRPNPSPFQPPAKVTKPSSKTGAIGLGTQSQPPTRTPrsg 536
Cdd:PHA03378 688 QWAPGTMQPP------------PRAPTPMRPPAAPPGRAQ-RPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAP--- 751
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532 537 aVSAQRLQSTLNLNSPASVCSGSSAKATQGSKGkntvSVAKKQPQSkgvcrnpGPGSSKSPGRTPLSIVTVPQSATKTET 616
Cdd:PHA03378 752 -GRARPPAAAPGRARPPAAAPGAPTPQPPPQAP----PAPQQRPRG-------APTPQPPPQAGPTSMQLMPRAAPGQQG 819
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 755534532 617 VSKSAKTAMKGQYSAKGPPKSSKP-------PTSFRDPPSSGKGA 654
Cdd:PHA03378 820 PTKQILRQLLTGGVKRGRPSLKKPaalerqaAAGPTPSPGSGTSD 864
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
70-166 1.29e-04

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 41.81  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  70 AERLLEELDNGVLLCQLINVLQnmvkgchsdePGNFPMRKVPCKKDAASGSFFARDNTANFLHWCRHIGVDETYLFeSEG 149
Cdd:cd21273   22 PEDLAEALSNGAVLCQLANQLR----------PRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMGVPEVDLC-SPS 90
                         90
                 ....*....|....*..
gi 755534532 150 LVLHKDPRQVYLCLLEI 166
Cdd:cd21273   91 DVLLQGPAAVLRTVLAL 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
351-650 1.56e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  351 LPGARLPAS---SVKGNLASP-------STRAKRPDSPASFPHPKVTSLKDAAKKTTAPSNSVSQSLASPNP-------- 412
Cdd:PHA03247 2555 LPPAAPPAApdrSVPPPRPAPrpsepavTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPpppspspa 2634
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  413 ---------GSKPSTAQCASESSRKCVTFPKTAQTKAIPAQNSRDLSKSRlLPSKSPGKMEPKHLKHNHLSSRD-ESRIN 482
Cdd:PHA03247 2635 anepdphppPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR-RRAARPTVGSLTSLADPPPPPPTpEPAPH 2713
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  483 LSSKSPKLPKGAMHGRPNPSPfqPPAKVTKPSSKTGAIGLGTQSQPPTR----TPRSGAVSAQRLQSTLNLNSPASVCSG 558
Cdd:PHA03247 2714 ALVSATPLPPGPAAARQASPA--LPAAPAPPAVPAGPATPGGPARPARPpttaGPPAPAPPAAPAAGPPRRLTRPAVASL 2791
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  559 SSAKATQGSKGKNTVSVAKKQPQSKGVCRNPGPGSSKSPGRTPLSIVTVPQSATKTETVSKSAKTAMKGQYSAKGPPKSS 638
Cdd:PHA03247 2792 SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSP 2871
                         330
                  ....*....|...
gi 755534532  639 KP-PTSFRDPPSS 650
Cdd:PHA03247 2872 AAkPAAPARPPVR 2884
CH_CNN2 cd21283
calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral ...
53-164 2.39e-04

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409132 [Multi-domain]  Cd Length: 109  Bit Score: 41.07  E-value: 2.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  53 QEDLSIWLSGLLGVDIKAErLLEELDNGVLLCQLINVLQnmvkgchsdePGNFPmrkvpcKKDAASGSFFARDNTANFLH 132
Cdd:cd21283    5 EAELRTWIEGLTGRSIGPD-FQKGLKDGVILCELMNKLQ----------PGSVP------KINRSMQNWHQLENLSNFIK 67
                         90       100       110
                 ....*....|....*....|....*....|..
gi 755534532 133 WCRHIGVDETYLFESEGLVLHKDPRQVYLCLL 164
Cdd:cd21283   68 AMVSYGMKPVDLFEANDLFESGNMTQVQVSLL 99
CH_VAV cd21201
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ...
73-150 3.86e-04

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.


Pssm-ID: 409050  Cd Length: 117  Bit Score: 40.70  E-value: 3.86e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755534532  73 LLEELDNGVLLCQLINVLQnmvkgchsdePGNFPMRKVpCKKDAASgSFFARDNTANFLHWCR-HIGVDETYLFESEGL 150
Cdd:cd21201   32 LAQALRDGVLLCQLLNRLS----------PGSVDDREI-NLRPQMS-QFLCLKNIRTFLQACRtVFGLRSADLFEPEDL 98
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
310-515 5.80e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 5.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532 310 PARTPQPPEMNPLSAVNMFQKQNLRPGTPVS-----VPKNKEKQVRLPGARLPASSvkgNLASPSTRAKRPDSPASFPHP 384
Cdd:PTZ00449 563 PAKEHKPSKIPTLSKKPEFPKDPKHPKDPEEpkkpkRPRSAQRPTRPKSPKLPELL---DIPKSPKRPESPKSPKRPPPP 639
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532 385 KVTSLKDAAKKTTAPSNsvSQSLASPNPGSKPSTAQCASESSRKCVTFPKTAQTKAIPAQNSRDLSKSRLLPSKSPGKME 464
Cdd:PTZ00449 640 QRPSSPERPEGPKIIKS--PKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTT 717
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755534532 465 PKHLkhnhlssrdesrinlsskSPKLPkgamhgRPNPSPFQPPAKVTKPSS 515
Cdd:PTZ00449 718 PRPL------------------PPKLP------RDEEFPFEPIGDPDAEQP 744
CH_CNN3 cd21284
calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic ...
53-174 1.35e-03

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409133 [Multi-domain]  Cd Length: 111  Bit Score: 38.73  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  53 QEDLSIWLSGLLGVDIkAERLLEELDNGVLLCQLINVLQnmvkgchsdePGNfpMRKVpckkDAASGSFFARDNTANFLH 132
Cdd:cd21284    7 EEELRNWIEEVTGMSI-GENFQKGLKDGVILCELINKLQ----------PGS--IRKI----NESKLNWHQLENIGNFIK 69
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755534532 133 WCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYG 174
Cdd:cd21284   70 AIQAYGMKPHDIFEANDLFENGNMTQVQTTLLALAGLAKTKG 111
IQG1 COG5261
Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and ...
54-177 2.95e-03

Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms];


Pssm-ID: 227586 [Multi-domain]  Cd Length: 1054  Bit Score: 41.02  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532   54 EDLSIWLSGLLGVDIKAERLLEELDNGVLLCQLINVLQ-NMVKGChsdepgnFPMRKVpckkdaasgSFFARDNTANFLH 132
Cdd:COG5261    47 SEAKIWIEEVIEEALPELCFEDSLRNGVFLAKLTQRFNpDLTTVI-------FPADKL---------QFRHTDNINAFLD 110
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 755534532  133 WCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGVEP 177
Cdd:COG5261   111 LIEHVGLPESFHFELQDLYEKKNIPKVIYCIHALISMLSWPGKTP 155
PHA03247 PHA03247
large tegument protein UL36; Provisional
305-576 5.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  305 SVPDSPArTPQPPEMNPLSAVNMFQKQNLRPGTPVSVPKNKEKQVRLPGARLPASSVKGNLASPSTRAKrPDSPASFPHP 384
Cdd:PHA03247 2731 ASPALPA-APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL-PSPWDPADPP 2808
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  385 KVTSLKDAAKKTTA--------PSNSVSQSLASPNPGSKPSTAQCAS-----ESSRKcvtfPKTAQTKAIPAQNSRDLSK 451
Cdd:PHA03247 2809 AAVLAPAAALPPAAspagplppPTSAQPTAPPPPPGPPPPSLPLGGSvapggDVRRR----PPSRSPAAKPAAPARPPVR 2884
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534532  452 SRLLPSKSPgkmEPKHLKHNHLSSRDESRINLSSKSPKLPKGAMHGRPNPSPFQPPAKVTKPSSKTGAIGLGtQSQPPTR 531
Cdd:PHA03247 2885 RLARPAVSR---STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAG-EPSGAVP 2960
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 755534532  532 TPRSGAVSAQRLQSTLNLNSPASVCSGSSAKATQGSKGKNTVSVA 576
Cdd:PHA03247 2961 QPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVS 3005
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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