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Conserved domains on  [gi|755542844|ref|XP_011242434|]
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leucine-rich repeat transmembrane protein FLRT2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 2.59e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 2.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  50 NERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLDISN 285
Cdd:COG4886  230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                        250       260
                 ....*....|....*....|....*
gi 755542844 286 NQLRMLTQGVFDHLSNLKQLTARNN 310
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLL 330
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 4.28e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.01  E-value: 4.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844   282 DISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 755542844   359 S 359
Cdd:TIGR00864   77 D 77
fn3 pfam00041
Fibronectin type III domain;
426-494 1.15e-06

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.15e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755542844  426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRSTYRICLV 494
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 4.36e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 4.36e-04
                          10        20
                  ....*....|....*....|....*...
gi 755542844   35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 2.59e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 2.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  50 NERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLDISN 285
Cdd:COG4886  230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                        250       260
                 ....*....|....*....|....*
gi 755542844 286 NQLRMLTQGVFDHLSNLKQLTARNN 310
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLL 330
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
26-265 3.35e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.44  E-value: 3.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  26 LYLQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNagFPAELHNvqSVHTVYLYGNQLDEFPM 105
Cdd:PRK15370 204 LILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITE--LPERLPS--ALQSLDLFHNKISCLPE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 106 NLPKNVRVLHLQENNIQTISRAALAQLLkleELHLDDNSIStvgvedgAFREAI--SLKLLFLSKNHLSSVPVGLPVDLQ 183
Cdd:PRK15370 280 NLPEELRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLT-------ALPETLppGLKTLEAGENALTSLPASLPPELQ 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 184 ELRVDENRIAVISDMAFQNLTSLErliVDGNLLTNkgIAEGTFSHLtKLKEFSivRNSLSHPPPDLP-----GTHLIRLY 258
Cdd:PRK15370 350 VLDVSKNQITVLPETLPPTITTLD---VSRNALTN--LPENLPAAL-QIMQAS--RNNLVRLPESLPhfrgeGPQPTRII 421


                 ....*..
gi 755542844 259 LQDNQIN 265
Cdd:PRK15370 422 VEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-311 9.27e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.75  E-value: 9.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  89 SVHTVYLYGNQLDEFP-MNLPKNVRVLHLQENNIQTISraALAQLLKLEELHLDDNSISTVGVEDGafreAISLKLLFLS 167
Cdd:cd21340    3 RITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENLEN----LVNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 168 KNHLSSVpVGL--PVDLQELRVDEnriavisdmafQNLTSLERLIVDGNLLTNkgiaegtfshltklkefsiVRNSLSHp 245
Cdd:cd21340   77 GNRISVV-EGLenLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAA-------------------LSNSLRV- 124

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755542844 246 ppdlpgthlirLYLQDNQINHipLTAFANLRKLERLDISNNQLRMLTQ--GVFDHLSNLKQLTARNNP 311
Cdd:cd21340  125 -----------LNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
252-311 1.36e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.36e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  252 THLIRLYLQDNQINHIPLTAFANLRKLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNP 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 4.28e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.01  E-value: 4.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844   282 DISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 755542844   359 S 359
Cdd:TIGR00864   77 D 77
LRRCT smart00082
Leucine rich repeat C-terminal domain;
310-361 9.60e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 9.60e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 755542844   310 NPWFCDCSIKWVTEWL---KYIPSSLNVRgfmCQGPEQVRGmAVRELNMNLLSCP 361
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQDPVDLR---CASPSSLRG-PLLELLHSEFKCP 51
fn3 pfam00041
Fibronectin type III domain;
426-494 1.15e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.15e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755542844  426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRSTYRICLV 494
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LRRNT smart00013
Leucine rich repeat N-terminal domain;
35-66 2.98e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 2.98e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 755542844    35 ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVT 66
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 4.36e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 4.36e-04
                          10        20
                  ....*....|....*....|....*...
gi 755542844   35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 336-361 9.48e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 33.95  E-value: 9.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 755542844  336 GFMCQGPEQVRGMAVRELNMNLLSCP 361
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSCS 26
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 2.59e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 2.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  50 NERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLDISN 285
Cdd:COG4886  230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                        250       260
                 ....*....|....*....|....*
gi 755542844 286 NQLRMLTQGVFDHLSNLKQLTARNN 310
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLL 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-313 7.23e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 7.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  48 YCNERSLTSVPLGIPE--GVTVLYLHNNQINNagFPAELHNVQSVHTVYLYGNQLDEFPMNL--PKNVRVLHLQENNIQT 123
Cdd:COG4886  142 DLSNNQLTDLPEPLGNltNLKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 124 ISrAALAQLLKLEELHLDDNSISTVGvedgAFREAISLKLLFLSKNHLSSVPVGLPVD-LQELRVDENRIAVISDMAFQN 202
Cdd:COG4886  220 LP-EPLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELEL 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 203 LTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLD 282
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        250       260       270
                 ....*....|....*....|....*....|.
gi 755542844 283 ISNNQLRMLTQGVFDHLSNLKQLTARNNPWF 313
Cdd:COG4886  375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
26-265 3.35e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.44  E-value: 3.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  26 LYLQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNagFPAELHNvqSVHTVYLYGNQLDEFPM 105
Cdd:PRK15370 204 LILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITE--LPERLPS--ALQSLDLFHNKISCLPE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 106 NLPKNVRVLHLQENNIQTISRAALAQLLkleELHLDDNSIStvgvedgAFREAI--SLKLLFLSKNHLSSVPVGLPVDLQ 183
Cdd:PRK15370 280 NLPEELRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLT-------ALPETLppGLKTLEAGENALTSLPASLPPELQ 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 184 ELRVDENRIAVISDMAFQNLTSLErliVDGNLLTNkgIAEGTFSHLtKLKEFSivRNSLSHPPPDLP-----GTHLIRLY 258
Cdd:PRK15370 350 VLDVSKNQITVLPETLPPTITTLD---VSRNALTN--LPENLPAAL-QIMQAS--RNNLVRLPESLPhfrgeGPQPTRII 421


                 ....*..
gi 755542844 259 LQDNQIN 265
Cdd:PRK15370 422 VEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-311 9.27e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.75  E-value: 9.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  89 SVHTVYLYGNQLDEFP-MNLPKNVRVLHLQENNIQTISraALAQLLKLEELHLDDNSISTVGVEDGafreAISLKLLFLS 167
Cdd:cd21340    3 RITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENLEN----LVNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 168 KNHLSSVpVGL--PVDLQELRVDEnriavisdmafQNLTSLERLIVDGNLLTNkgiaegtfshltklkefsiVRNSLSHp 245
Cdd:cd21340   77 GNRISVV-EGLenLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAA-------------------LSNSLRV- 124

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755542844 246 ppdlpgthlirLYLQDNQINHipLTAFANLRKLERLDISNNQLRMLTQ--GVFDHLSNLKQLTARNNP 311
Cdd:cd21340  125 -----------LNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-310 9.95e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 9.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 105 MNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQE 184
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 185 LRVDEnRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAegtFSHLTKLKEFSIVRNSLSHPPPDLPG-THLIRLYLQDNQ 263
Cdd:COG4886   95 LTNLT-ELDLSGNEELSNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGNlTNLKSLDLSNNQ 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 755542844 264 INHIPlTAFANLRKLERLDISNNQLRMLTQgVFDHLSNLKQLTARNN 310
Cdd:COG4886  171 LTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-246 1.99e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.81  E-value: 1.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  47 VYCNERSLTSVP-LGIPEGVTVLYLHNNQINNAgfpAELHNVQSVHTVYLYGNQLDEFPM--NLpKNVRVLHLQENNIQT 123
Cdd:cd21340    7 LYLNDKNITKIDnLSLCKNLKVLYLYDNKITKI---ENLEFLTNLTHLYLQNNQIEKIENleNL-VNLKKLYLGGNRISV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 124 ISraALAQLLKLEELHL-------------DDNSISTVgvedgafreAISLKLLFLSKNHLSsvpvglpvDLQELrvden 190
Cdd:cd21340   83 VE--GLENLTNLEELHIenqrlppgekltfDPRSLAAL---------SNSLRVLNISGNNID--------SLEPL----- 138

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755542844 191 riavisdmafQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
Cdd:cd21340  139 ----------APLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-295 1.16e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.80  E-value: 1.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  54 LTSVPLGIPEGVTVLYLHNNQinnagfpaelhnvqsvhtvylygnqLDEFPMNLPKNVRVLHLQENNIQTISrAALAQll 133
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNE-------------------------LKSLPENLQGNIKTLYANSNQLTSIP-ATLPD-- 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 134 KLEELHLDDNSISTVgvedgAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAV--------ISDMAFQN--L 203
Cdd:PRK15370 242 TIQEMELSINRITEL-----PERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTlpahlpsgITHLNVQSnsL 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 204 T--------SLERLIVDGNLLTNkgIAEgtfSHLTKLKEFSIVRNSLSHPPPDLPGThLIRLYLQDNQINHIPLTAFANL 275
Cdd:PRK15370 317 TalpetlppGLKTLEAGENALTS--LPA---SLPPELQVLDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAAL 390

                        250       260
                 ....*....|....*....|
gi 755542844 276 RKLErldISNNQLRMLTQGV 295
Cdd:PRK15370 391 QIMQ---ASRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
252-311 1.36e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.36e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  252 THLIRLYLQDNQINHIPLTAFANLRKLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNP 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 65-223 2.42e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.27  E-value: 2.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  65 VTVLYLHNNQINNAGFPA---ELHNVQSVHTVYLYGNQLDEFPMNL-------PKNVRVLHLQENNIQTISRAALAQLLK 134
Cdd:COG5238  238 LTTLDLSNNQIGDEGVIAlaeALKNNTTVETLYLSGNQIGAEGAIAlakalqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 135 ----LEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSsvpvglpvdlqelrvDENRIAVISdmAFQNLTSL 206
Cdd:COG5238  318 gnktLHTLNLAYNGIGAQGAI--ALAKALqentTLHSLDLSDNQIG---------------DEGAIALAK--YLEGNTTL 378

                        170
                 ....*....|....*..
gi 755542844 207 ERLIVDGNLLTNKGIAE 223
Cdd:COG5238  379 RELNLGKNNIGKQGAEA 395
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 110-289 3.24e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.91  E-value: 3.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 110 NVRVLHLQENNIQTISRAALAQLLK----LEELHLDDN----SISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGL--- 178
Cdd:cd00116   24 CLQVLRLEGNTLGEEAAKALASALRpqpsLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVles 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 179 ---PVDLQELRVDENRIAvisDMAFQNLT--------SLERLIVDGNLLTNKGIAE--GTFSHLTKLKEFSIVRNSLSHP 245
Cdd:cd00116  104 llrSSSLQELKLNNNGLG---DRGLRLLAkglkdlppALEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDA 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755542844 246 -----PPDLPG-THLIRLYLQDNQINHIPLTAFA----NLRKLERLDISNNQLR 289
Cdd:cd00116  181 giralAEGLKAnCNLEVLDLNNNGLTDEGASALAetlaSLKSLEVLNLGDNNLT 234
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 4.28e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.01  E-value: 4.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844   282 DISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 755542844   359 S 359
Cdd:TIGR00864   77 D 77
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
51-268 4.31e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.32  E-value: 4.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  51 ERSLTSVPLGIPEGVTVLYLHNNQINN-AGFPAELHnvqsvhTVYLYGNQLDEFPMnLPKNVRVLHLQENNIQTISR--A 127
Cdd:PRK15387 210 ESGLTTLPDCLPAHITTLVIPDNNLTSlPALPPELR------TLEVSGNQLTSLPV-LPPGLLELSIFSNPLTHLPAlpS 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 128 ALAQLL--------------KLEELHLDDNSISTVgvedgafrEAISLKL--LFLSKNHLSSVPVgLPVDLQELRVDENR 191
Cdd:PRK15387 283 GLCKLWifgnqltslpvlppGLQELSVSDNQLASL--------PALPSELckLWAYNNQLTSLPT-LPSGLQELSVSDNQ 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 192 IAVISDM--------AFQN-LTS-------LERLIVDGNLLTNKGIAEgtfshlTKLKEFSIVRNSLSHPPPdLPgTHLI 255
Cdd:PRK15387 354 LASLPTLpselyklwAYNNrLTSlpalpsgLKELIVSGNRLTSLPVLP------SELKELMVSGNRLTSLPM-LP-SGLL 425

                        250
                 ....*....|...
gi 755542844 256 RLYLQDNQINHIP 268
Cdd:PRK15387 426 SLSVYRNQLTRLP 438
LRR_8 pfam13855
Leucine rich repeat;
204-288 1.23e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  204 TSLERLIVDGNLLTNkgIAEGTFSHLTKLKEfsivrnslshpppdlpgthlirLYLQDNQINHIPLTAFANLRKLERLDI 283
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKV----------------------LDLSNNLLTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 755542844  284 SNNQL 288
Cdd:pfam13855  57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
182-242 3.50e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755542844  182 LQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTnkGIAEGTFSHLTKLKEFSIVRNSL 242
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
110-171 7.02e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 7.02e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755542844  110 NVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTvgVEDGAFREAISLKLLFLSKNHL 171
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
310-361 9.60e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 9.60e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 755542844   310 NPWFCDCSIKWVTEWL---KYIPSSLNVRgfmCQGPEQVRGmAVRELNMNLLSCP 361
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQDPVDLR---CASPSSLRG-PLLELLHSEFKCP 51
fn3 pfam00041
Fibronectin type III domain;
426-494 1.15e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.15e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755542844  426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRSTYRICLV 494
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 52-192 2.00e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  52 RSLTSVPlgipEGVTVLYLHNNQINNAGFPA---ELHNVQSVHTVYLYGNQLDE---------FPMNlpKNVRVLHLQEN 119
Cdd:cd00116  130 KGLKDLP----PALEKLVLGRNRLEGASCEAlakALRANRDLKELNLANNGIGDagiralaegLKAN--CNLEVLDLNNN 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 120 -----NIQTISrAALAQLLKLEELHLDDNSISTVGVE---DGAFREAISLKLLFLSKNHLSSVPV-----GLP--VDLQE 184
Cdd:cd00116  204 gltdeGASALA-ETLASLKSLEVLNLGDNNLTDAGAAalaSALLSPNISLLTLSLSCNDITDDGAkdlaeVLAekESLLE 282


                 ....*...
gi 755542844 185 LRVDENRI 192
Cdd:cd00116  283 LDLRGNKF 290
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 53-288 2.13e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.56  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  53 SLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFP-------MNLPKNVRVLHLQENNIQTIS 125
Cdd:COG5238  145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGieelaeaLTQNTTVTTLWLKRNPIGDEG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 126 RAALAQLLK----LEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSsvpvglpvdlqelrvDENRIAVISd 197
Cdd:COG5238  225 AEILAEALKgnksLTTLDLSNNQIGDEGVI--ALAEALknntTVETLYLSGNQIG---------------AEGAIALAK- 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 198 mAFQNLTSLERLIVDGNLLTNKG---IAEGtfshltklkefsivrnslshpppdLPGTHLIR-LYLQDNQINH---IPL- 269
Cdd:COG5238  287 -ALQGNTTLTSLDLSVNRIGDEGaiaLAEG------------------------LQGNKTLHtLNLAYNGIGAqgaIALa 341

                        250
                 ....*....|....*....
gi 755542844 270 TAFANLRKLERLDISNNQL 288
Cdd:COG5238  342 KALQENTTLHSLDLSDNQI 360
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-288 6.06e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  81 PAELHNVQSVHTVYLYGNQL-DEFPMNL--PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSIStvGVEDGAFRE 157
Cdd:PLN00113 253 PSSLGNLKNLQYLFLYQNKLsGPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--GKIPVALTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 158 AISLKLLFLSKNHLSSvpvGLPVDLQElrvdENRIAVIsDMAFQNLTSlerLIVDGnlLTNKGiaegtfsHLTKLKEFSi 237
Cdd:PLN00113 331 LPRLQVLQLWSNKFSG---EIPKNLGK----HNNLTVL-DLSTNNLTG---EIPEG--LCSSG-------NLFKLILFS- 389

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755542844 238 vrNSL-SHPPPDLPGTH-LIRLYLQDNQINHIPLTAFANLRKLERLDISNNQL 288
Cdd:PLN00113 390 --NSLeGEIPKSLGACRsLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
LRR_8 pfam13855
Leucine rich repeat;
134-216 6.26e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 6.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  134 KLEELHLDDNSIStvGVEDGAFREAISLKLLFLSKNHLSSvpvglpvdlqelrvdenriavISDMAFQNLTSLERLIVDG 213
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTT---------------------LSPGAFSGLPSLRYLDLSG 58


                  ...
gi 755542844  214 NLL 216
Cdd:pfam13855  59 NRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
47-206 1.83e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  47 VYCNerSLTSVPLGIPEGVTVLYLHNNQINnaGFPAELHnvQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIqtisr 126
Cdd:PRK15370 290 VYDN--SIRTLPAHLPSGITHLNVQSNSLT--ALPETLP--PGLKTLEAGENALTSLPASLPPELQVLDVSKNQI----- 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 127 AALAQLL--KLEELHLDDNSISTVGVEDGAfreaiSLKLLFLSKNHLSSVPVGLPVDLQElRVDENRIAV----ISDMAF 200
Cdd:PRK15370 359 TVLPETLppTITTLDVSRNALTNLPENLPA-----ALQIMQASRNNLVRLPESLPHFRGE-GPQPTRIIVeynpFSERTI 432


                 ....*.
gi 755542844 201 QNLTSL 206
Cdd:PRK15370 433 QNMQRL 438
LRR_8 pfam13855
Leucine rich repeat;
88-145 9.79e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 9.79e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755542844   88 QSVHTVYLYGNQL----DEFPMNLPkNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSI 145
Cdd:pfam13855   1 PNLRSLDLSNNRLtsldDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 59-288 2.45e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  59 LGIPEGVTVLYLHNNQINNAgFPAELHNVQSVHTVYLYGNQLD-EFPMNLP--KNVRVLHLQENNIQTISRAALAQLLKL 135
Cdd:PLN00113 352 LGKHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLV 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 136 EELHLDDNSIStvGVEDGAFREAISLKLLFLSKNHLSSvpvGLP-----VDLQELRVDENRIAVISDMAFQNLTSLERLI 210
Cdd:PLN00113 431 YFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFG---GLPdsfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLK 505

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755542844 211 VDGNLLTNKgIAEgtfshltklkEFSIVRNslshpppdlpgthLIRLYLQDNQIN-HIPLTaFANLRKLERLDISNNQL 288
Cdd:PLN00113 506 LSENKLSGE-IPD----------ELSSCKK-------------LVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQL 559
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 112-242 2.63e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 112 RVLHLQENNI-----QTISRAALAQLLKLEELHLDDNSISTVGVED--GAFREAISLKLLFLSKNHLS-----SVPVGLP 179
Cdd:cd00116  111 QELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGdagirALAEGLK 190

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755542844 180 VD--LQELRVDENRI----AVISDMAFQNLTSLERLIVDGNLLTNKGIAE---GTFSHLTKLKEFSIVRNSL 242
Cdd:cd00116  191 ANcnLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTDAGAAAlasALLSPNISLLTLSLSCNDI 262
LRRNT smart00013
Leucine rich repeat N-terminal domain;
35-66 2.98e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 2.98e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 755542844    35 ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVT 66
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 4.36e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 4.36e-04
                          10        20
                  ....*....|....*....|....*...
gi 755542844   35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 111-288 5.84e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 5.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 111 VRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTvGVEDGAFREAISLKLLFLSKNHLS-SVPVGLPVDLQELRVDE 189
Cdd:PLN00113  71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSN 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844 190 N--------RIAVISDMAF----------------QNLTSLERLIVDGNLLTN------------KGIAEG--------- 224
Cdd:PLN00113 150 NmlsgeipnDIGSFSSLKVldlggnvlvgkipnslTNLTSLEFLTLASNQLVGqiprelgqmkslKWIYLGynnlsgeip 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755542844 225 -TFSHLTKLKEFSIVRNSLSHPPP----DLPGTHLIRLYlQDNQINHIPLTAFaNLRKLERLDISNNQL 288
Cdd:PLN00113 230 yEIGGLTSLNHLDLVYNNLTGPIPsslgNLKNLQYLFLY-QNKLSGPIPPSIF-SLQKLISLDLSDNSL 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 65-145 1.29e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  65 VTVLYLHNNQINNAGFPAELHNVQ---SVHTVYLYGNQLD--------EFPMNLPkNVRVLHLQENNIQTISRAALAQLL 133
Cdd:COG5238  322 LHTLNLAYNGIGAQGAIALAKALQentTLHSLDLSDNQIGdegaialaKYLEGNT-TLRELNLGKNNIGKQGAEALIDAL 400

                         90
                 ....*....|....*
gi 755542844 134 KLEELH---LDDNSI 145
Cdd:COG5238  401 QTNRLHtliLDGNLI 415
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 195-306 5.54e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.52  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542844  195 ISDMAFQNlTSLERLIVDGNLLTnkgIAEGTFSHLTKLKEFSIvrnslshpPPDLP--------GTHLIRLYLQDNqINH 266
Cdd:pfam13306   3 IGSYAFYN-CSLTSITIPSSLTS---IGEYAFSNCTSLKSITL--------PSSLTsigsyafyNCSLTSITIPSS-LTS 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 755542844  267 IPLTAFANLRKLERLDISNNqLRMLTQGVFDHlSNLKQLT 306
Cdd:pfam13306  70 IGEYAFSNCSNLKSITLPSN-LTSIGSYAFSN-CSLKSIT 107
LRR smart00370
Leucine-rich repeats, outliers;
275-298 8.55e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 8.55e-03
                           10        20
                   ....*....|....*....|....
gi 755542844   275 LRKLERLDISNNQLRMLTQGVFDH 298
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
275-298 8.55e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 8.55e-03
                           10        20
                   ....*....|....*....|....
gi 755542844   275 LRKLERLDISNNQLRMLTQGVFDH 298
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 336-361 9.48e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 33.95  E-value: 9.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 755542844  336 GFMCQGPEQVRGMAVRELNMNLLSCP 361
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSCS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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