PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) finger typically characterized as Cys4HisCys3, and a non-canonical extended PHD finger, characterized as Cys2HisCys5HisCys2His. Variations include the RAG2 PHD finger characterized by Cys3His2Cys2His and the PHD finger 5 found in nuclear receptor-binding SET domain-containing proteins characterized by Cys4HisCys2His. The PHD finger is also termed LAP (leukemia-associated protein) motif or TTC (trithorax consensus) domain. Single or multiple copies of PHD fingers have been found in a variety of eukaryotic proteins involved in the control of gene transcription and chromatin dynamics. PHD fingers can recognize the unmodified and modified histone H3 tail, and some have been found to interact with non-histone proteins. They also function as epigenome readers controlling gene expression through molecular recruitment of multi-protein complexes of chromatin regulators and transcription factors. The PHD finger domain SF is structurally similar to the RING and FYVE_like superfamilies.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551344 1733 CCLCGKWASYRNMGDLFGPFYpqdyaatlpknpppkrssemqskvkvrhksasngsktdteeeeeqqqqkeqrslaahpr 1812
Cdd:cd15699     1 CCLCGKWANYRNLGDLFGPFY----------------------------------------------------------- 21

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551344 1813 fkrrhrsedcgggprslsrglpckkaategssektvsdtkpsvpttseggpelelqipelpldsnEFWVHEGCILWANGI 1892
Cdd:cd15699    22 -----------------------------------------------------------------EFWVHEGCILWANGI 36

                         170       180
                  ....*....|....*....|....
gi 755551344 1893 YLVCGRLYGLQEALEIAREMKCSH 1916
Cdd:cd15699    37 YLVCGRLYGLQEALDIAREMKCSH 60

Extended PHD finger (ePHD) found in transcription factor 20 (TCF-20); The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This model corresponds to the C-terminal ePHD/ADD (ATRX-DNMT3-DNMT3L) domain of TCF-20. TCF-20, also termed nuclear factor SPBP, or protein AR1, or stromelysin-1 PDGF (platelet-derived growth factor)-responsive element-binding protein (SPRE-binding protein), is involved in transcriptional activation of the MMP3 (matrix metalloprotease 3) promoter. It is strongly enriched on chromatin in interphase HeLa cells, and displays low nuclear mobility, and has been implicated in Smith-Magenis syndrome and Potocki-Lupski syndrome. As a chromatin-binding protein, TCF-20 plays a role in the regulation of gene expression. It also functions as a transcriptional co-regulator that enhances or represses the transcriptional activity of certain transcription factors/cofactors, such as specificity protein 1 (Sp1), E twenty-six 1 (Ets1), paired box protein 6 (Pax6), small nuclear RING-finger (SNURF)/RNF4, c-Jun, androgen receptor (AR) and estrogen receptor alpha (ERalpha). TCF-20 contains an N-terminal transactivation domain, a novel DNA-binding domain with an AT-hook motif, three nuclear localization signals (NLSs) and a C-terminal ePHD/ADD domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551344 1733 CCLCGKWASYRNMGDLFGPFYpqdyaatlpknpppkrssemqskvkvrhksasngsktdteeeeeqqqqkeqrslaahpr 1812
Cdd:cd15699     1 CCLCGKWANYRNLGDLFGPFY----------------------------------------------------------- 21

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551344 1813 fkrrhrsedcgggprslsrglpckkaategssektvsdtkpsvpttseggpelelqipelpldsnEFWVHEGCILWANGI 1892
Cdd:cd15699    22 -----------------------------------------------------------------EFWVHEGCILWANGI 36

                         170       180
                  ....*....|....*....|....
gi 755551344 1893 YLVCGRLYGLQEALEIAREMKCSH 1916
Cdd:cd15699    37 YLVCGRLYGLQEALDIAREMKCSH 60

Extended PHD finger (ePHD) found in transcription factor 20 (TCF-20); The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This model corresponds to the C-terminal ePHD/ADD (ATRX-DNMT3-DNMT3L) domain of TCF-20. TCF-20, also termed nuclear factor SPBP, or protein AR1, or stromelysin-1 PDGF (platelet-derived growth factor)-responsive element-binding protein (SPRE-binding protein), is involved in transcriptional activation of the MMP3 (matrix metalloprotease 3) promoter. It is strongly enriched on chromatin in interphase HeLa cells, and displays low nuclear mobility, and has been implicated in Smith-Magenis syndrome and Potocki-Lupski syndrome. As a chromatin-binding protein, TCF-20 plays a role in the regulation of gene expression. It also functions as a transcriptional co-regulator that enhances or represses the transcriptional activity of certain transcription factors/cofactors, such as specificity protein 1 (Sp1), E twenty-six 1 (Ets1), paired box protein 6 (Pax6), small nuclear RING-finger (SNURF)/RNF4, c-Jun, androgen receptor (AR) and estrogen receptor alpha (ERalpha). TCF-20 contains an N-terminal transactivation domain, a novel DNA-binding domain with an AT-hook motif, three nuclear localization signals (NLSs) and a C-terminal ePHD/ADD domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551344 1733 CCLCGKWASYRNMGDLFGPFYpqdyaatlpknpppkrssemqskvkvrhksasngsktdteeeeeqqqqkeqrslaahpr 1812
Cdd:cd15699     1 CCLCGKWANYRNLGDLFGPFY----------------------------------------------------------- 21

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551344 1813 fkrrhrsedcgggprslsrglpckkaategssektvsdtkpsvpttseggpelelqipelpldsnEFWVHEGCILWANGI 1892
Cdd:cd15699    22 -----------------------------------------------------------------EFWVHEGCILWANGI 36

                         170       180
                  ....*....|....*....|....
gi 755551344 1893 YLVCGRLYGLQEALEIAREMKCSH 1916
Cdd:cd15699    37 YLVCGRLYGLQEALDIAREMKCSH 60

Extended PHD finger (ePHD) found in retinoic acid-induced protein 1 (RAI1); The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This model corresponds to the C-terminal ePHD/ADD (ATRX-DNMT3-DNMT3L) domain of RAI1. RAI1, a homolog of stromelysin-1 PDGF (platelet-derived growth factor)-responsive element-binding protein (SPBP, also termed TCF-20), is a chromatin-binding protein implicated in the regulation of gene expression. It is strongly enriched on chromatin in interphase HeLa cells, and displays low nuclear mobility, and has been implicated in Smith-Magenis syndrome, Potocki-Lupski syndrome, and non-syndromic autism. RAI1 contains a region with homology to the novel nucleosome-binding region SPBP and an ePHD/ADD domain with ability to bind nucleosomes.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 755551344 1878 EFWVHEGCILWANGIYLVCGRLYGLQEALEIAREMKCS 1915
Cdd:cd15700    23 EHWVHEACAVWTTGVYLVAGKLFGLQEAVQKAADAKCS 60